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Relevant bibliographies by topics / Scramble Mutation

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Academic literature on the topic 'Scramble Mutation'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Scramble Mutation"

1

Kalafati, Eleni, Nefeli Mavrianou Koutsoukou, Alexandra Papadimou, et al. "CXCR4 S338X Promotes Resistance to Second Generation BTK Inhibitor and BCL-2 Inhibitor in WM Cells." Blood 142, Supplement 1 (2023): 6600. http://dx.doi.org/10.1182/blood-2023-180658.

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Introduction: Waldenström macroglobulinemia (WM) is an IgM-secreting lymphoplasmacytic lymphoma. CXCR4 somatic mutations are common in WM and are associated with clinical resistance to Bruton's tyrosine kinase (BTK) inhibitors and other therapeutic agents. CXCR4 mutations occur nearly exclusively with MYD88 L265Pmutation, with CXCR4 S338X constituting the most common in WM patients. The aim of this study was to further investigate the effect of CXCR4 S338X on BTK inhibitors (ibrutinib and zanubrutinib) and a BCL-2 inhibitor (venetoclax) resistance. Methods: MWCL-1 cells were transfected with s

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2

Wirayanti, Ni Komang Ayu, and Haris Sriwindono. "Implementation of Hybrid Genetic Algorithm for Solving the Teacher Placement Problem." Social Science and Humanities Journal 9, no. 01 (2025): 6341–47. https://doi.org/10.18535/sshj.v9i01.1460.

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The teacher placement problem is a combinatorial problem that would take a very long time to solve in a deterministic way. In this study, the problem will be solved using a hybrid genetic algorithm, which combines genetic algorithms with local search methods. The genetic algorithm operators used include roulette wheel selection, two point crossover, and scramble mutation. While the local search used is reverse, insert, and swap local search. The results showed that from the three experiments using hybrid genetic algorithms, it was found that hybrid genetic algorithms were more effective than o

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Roccaro, Aldo M., Antonio Sacco, Cristina Jimenez, et al. "A Novel Activating Mutation Of CXCR4 Plays a Crucial Role In Waldenstrom Macroglobulinemia Biology." Blood 122, no. 21 (2013): 272. http://dx.doi.org/10.1182/blood.v122.21.272.272.

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Abstract Background The C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in modulating the biology of B-cell lymphoproliferative disorders. Recent whole genome sequencing studies have identified unique CXCR4 mutations in 29% of the 55 evaluated patients with Waldenstrom Macroglobulinemia (WM). In this study, we sought to better define the mutation status of CXCR4 in B-cell malignancies and define the functional role of this mutation in the progression of WM in vivo. Methods Allele-specific(AS) PCR has been performed on bone marrow (BM)-derived tumor cells of patients with WM (n: 13

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Fiore, Michele, Alberto Taddia, Valentina Indio, et al. "Molecular Signature of Biological Aggressiveness in Clear Cell Sarcoma of the Kidney (CCSK)." International Journal of Molecular Sciences 24, no. 4 (2023): 3743. http://dx.doi.org/10.3390/ijms24043743.

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Clear cell sarcoma of the kidney (CCSK) is a rare pediatric renal tumor with a worse prognosis than Wilms’ tumor. Although recently, BCOR internal tandem duplication (ITD) has been found as a driver mutation in more than 80% of cases, a deep molecular characterization of this tumor is still lacking, as well as its correlation with the clinical course. The aim of this study was to investigate the differential molecular signature between metastatic and localized BCOR-ITD-positive CCSK at diagnosis. Whole-exome sequencing (WES) and whole-transcriptome sequencing (WTS) were performed on six locali

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Zhu, Ding, Xiaojun Tong, Miao Zhang, and Zhu Wang. "A New S-Box Generation Method and Advanced Design Based on Combined Chaotic System." Symmetry 12, no. 12 (2020): 2087. http://dx.doi.org/10.3390/sym12122087.

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The construction of substitute box (S-box) has always been an important research direction in cryptography. This paper proposes a new S-box generation method and advanced design based on combined chaotic system. Firstly, our paper proposes a new combined chaotic system and analyze its dynamic behavior. Next, we construct S-box by combining the generated pseudo-random sequence with the linear congruence random number generator, and the standard mapping is introduced to scramble the initial S-box. Then, the S-box optimization method based on advanced genetic algorithm is proposed in this paper.

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Abdel-Basset, Mohamed, Reda Mohamed, Mohamed Abouhawwash, Victor Chang, and S. S. Askar. "A Local Search-Based Generalized Normal Distribution Algorithm for Permutation Flow Shop Scheduling." Applied Sciences 11, no. 11 (2021): 4837. http://dx.doi.org/10.3390/app11114837.

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This paper studies the generalized normal distribution algorithm (GNDO) performance for tackling the permutation flow shop scheduling problem (PFSSP). Because PFSSP is a discrete problem and GNDO generates continuous values, the largest ranked value rule is used to convert those continuous values into discrete ones to make GNDO applicable for solving this discrete problem. Additionally, the discrete GNDO is effectively integrated with a local search strategy to improve the quality of the best-so-far solution in an abbreviated version of HGNDO. More than that, a new improvement using the swap m

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Reddaiah, Buduri, Rao Kanusu Srinivasa, Chinthakunta Swetha, Godina Amruthavani, and Siddavatam Sivajyothi. "Linear Congruential Pseudorandom Numbered Hybrid Crypto-System with Genetic Algorithms." International Journal of Engineering and Advanced Technology (IJEAT) 10, no. 2 (2020): 159–63. https://doi.org/10.35940/ijeat.B2092.1210220.

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While using networks that may be in any form more and more problems related to securityrises within the network as well as outside the network. To resolve the security problems network security is the science that facilitatesto safeguard the resources and the quality of the network and data. At different workstations filters and firewalls are used in protecting the resources. But while the data is in transmission security services are needed to protect. These services are to be altered frequently to prevent from attacks. In developing such system, this work uses linear congruential pseudorando

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8

Kalafati, Eleni, Kostantina Taouxi, Ourania Theologi, et al. "The Combined Treatment of Btkis with Venetoclax Exhibits an Enhanced Therapeutic Effect on Waldenström Macroglobulinemia Cells Bearing CXCR4 Mutations." Blood 144, Supplement 1 (2024): 1603. https://doi.org/10.1182/blood-2024-205460.

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Waldenström macroglobulinemia (WM) is an IgM-secreting lymphoplasmacytic lymphoma characterized by recurrent somatic mutations in CXCR4 gene that are present in about 30-40% of WM patients always co-oocur with MYD88L265P mutation, and are associated with clinical resistance to therapeutic agents including Bruton's tyrosine kinase inhibitors (BTKIs). The aim of this study was to investigate the therapeutic effect of the combination of BTKIs, ibrutinib and 2nd generation zanubrutinib, with a BCL-2 inhibitor (venetoclax) in the CXCR4 mutated (CXCR4MUT)cells. MWCL-1, BCWM-1 and OCI-LY3 cells were

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Rahbek, L. W., C. R. Terp, U. Alibrandi, and P. H. Kirkegaard. "Stock Optimization of Naturally Curved Wood Logs on Freeform Truss Structures." Journal of the International Association for Shell and Spatial Structures 64, no. 4 (2023): 257–65. http://dx.doi.org/10.20898/j.iass.2023.029.

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This paper presents an optimization method for incorporating discarded naturally curved wood logs onto a freeform gridshell with a predefined topology. Though still little explored, the research field of reusing structural elements is experiencing increasing attention owing to its significant potential to reduce the environmental impact of building design. However, several constraints must be considered as the optimal structure depends on stock availability and the corresponding geometry and material properties of that given stock. Therefore, the focus is on determining the best configuration

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10

Dong, Alisa Cheung, Valentina Ghiaccio, Irene Motta, et al. "Adult Hemoglobin Production, Chain Rebalance, and Splice Correction in IVS2-745 Beta-Thalassemia Patient Cells Using 2'-O-Methoxyethyl Splice-Switching Oligos." Blood 128, no. 22 (2016): 1014. http://dx.doi.org/10.1182/blood.v128.22.1014.1014.

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Abstract Hemoglobinopathies are the most common inherited blood disorders. World Health Organization statistics show that in the Mediterranean, Eastern European, and Middle Eastern regions, frequencies range from 0.1 to 4.9/1000 of live births. The mutation known as IVS2-745 is relatively common in the regions of Spain, Jordan, Romania, and Serbia (Ithanet Database, http://www.ithanet.eu/db/ithamaps), reaching as high as 15-20% of beta-thalassemia mutations in these regions. The IVS2-745 is a splicing mutation that occurs in intron 2 of the beta-globin gene and results in an aberrantly spliced

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Dissertations / Theses on the topic "Scramble Mutation"

1

Suzuki, Takayuki. "Functional Swapping between Transmembrane Proteins TMEM16A and TMEM16F." Kyoto University, 2014. http://hdl.handle.net/2433/188693.

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2

Jacquelin, Cécile. "Caractérisation phénotypique, comportementale et neurochimique, de la souris mutante ataxique scrambler (Dab1scm)." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0345.

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La souris scrambler (Dab1scm) est un mutant ataxique cérébelleux qui présente une mutation naturelle du gène mdab1, codant pour une protéine intracellulaire nécessaire à la voie de signalisation de la rééline. Cette protéine joue un rôle crucial dans la mise place et la plasticité des structures laminées telles que le cortex cérébral, l’hippocampe ou le cervelet. Notre objectif a été de caractériser le phénotype comportemental et neurochimique de la souris scrambler au cours du développement post-natal et à l’âge adulte. Les premiers signes de l’ataxie cérébelleuse sont observables dès 8 jours

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