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Journal articles on the topic 'SCREENED FLAVONOIDS'

Author: Grafiati

Published: 11 September 2023

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1

de Almeida, Vitor Martins, and Osvaldo Andrade Santos-Filho. "Identification of Potential Allosteric Site Binders of Indoleamine 2,3-Dioxygenase 1 from Plants: A Virtual and Molecular Dynamics Investigation." Pharmaceuticals 15, no. 9 (2022): 1099. http://dx.doi.org/10.3390/ph15091099.

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Ligand and structure-based computational screenings were carried out to identify flavonoids with potential anticancer activity. Kushenol E, a flavonoid with proven anticancer activity and, at the same time, an allosteric site binder of the enzyme indoleamine 2,3-dioxygenase-1 (IDO1), was used as the reference compound. Molecular docking and molecular dynamics simulations were performed for the screened flavonoids with known anticancer activity. The following two of these flavonoids were identified as potential inhibitors of IDO1: dichamanetin and isochamanetin. Molecular dynamics simulations w

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Park, Seon-Joo, Varun Jaiswal, and Hae-Jeung Lee. "Dietary Intake of Flavonoids and Carotenoids Is Associated with Anti-Depressive Symptoms: Epidemiological Study and In Silico—Mechanism Analysis." Antioxidants 11, no. 1 (2021): 53. http://dx.doi.org/10.3390/antiox11010053.

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Flavonoids and carotenoids are bioactive compounds that have protective effects against depressive symptoms. Flavonoids and carotenoids are the two main types of antioxidant phytochemicals. This study investigated the association between flavonoid and carotenoid intake and depressive symptoms in middle-aged Korean females. We analyzed the mechanism of these associations using an in silico method. Depressive symptoms were screened using the Beck Depression Inventory-II (BDI-II), and flavonoid and carotenoid intake were assessed using a semi-quantitative food frequency questionnaire. Using a mul

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Qi, Zengxing, Ran Zhao, Jing Xu, Yanrui Ge, Ruofan Li, and Ruili Li. "Accumulation Pattern of Flavonoids during Fruit Development of Lonicera maackii Determined by Metabolomics." Molecules 26, no. 22 (2021): 6913. http://dx.doi.org/10.3390/molecules26226913.

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Lonicera maackii (Caprifoliaceae) is a large, upright shrub with fruits that contain many bioactive compounds. Flavonoids are common active substances in L. maackii. However, there is a dearth of information about the accumulation of these flavonoids and their possible medicinal value. We used targeted metabolomics analysis based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to analyze five developmental stages of L. maackii fruit. A total of 438 metabolites were identified in the five developmental stages, including 81 flavonoids and derivatives. The 81 flav

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Huang, Xiaolong, Guilian Sun, Qiaohong Li, and Huiqing Yan. "Transcriptome Analysis Reveals Regulatory Networks and Hub Genes in the Flavonoid Metabolism of Rosa roxburghii." Horticulturae 9, no. 2 (2023): 233. http://dx.doi.org/10.3390/horticulturae9020233.

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Rosa roxburghii Tratt, the most popular fruit that blooms in the southwest of China, has high antioxidant properties and is rich in different flavonoids. However, the regulatory network and critical genes that regulate the flavonoid biosynthesis of R. roxburghii are still unknown. In this study, HPLC analysis revealed that total flavonoids, anthocyanins, and catechin were enriched in mature fruits, flowers, and leaves, respectively. Differentially expressed genes (DEGs) between five organs of R. roxburghii involved in flavonoid metabolism were obtained by transcriptome sequencing. A total of 1

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Xu, Sherry L., Cathy W. C. Bi, Roy C. Y. Choi, et al. "Flavonoids Induce the Synthesis and Secretion of Neurotrophic Factors in Cultured Rat Astrocytes: A Signaling Response Mediated by Estrogen Receptor." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/127075.

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Neurotrophic factors are playing vital roles in survival, growth, and function of neurons. Regulation of neurotrophic factors in the brain has been considered as one of the targets in developing drug or therapy against neuronal disorders. Flavonoids, a family of multifunctional natural compounds, are well known for their neuronal beneficial effects. Here, the effects of flavonoids on regulating neurotrophic factors were analyzed in cultured rat astrocytes. Astrocyte is a major secreting source of neurotrophic factors in the brain. Thirty-three flavonoids were screened in the cultures, and caly

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Xu, Haishun, Xue Dai, Xue Hu, et al. "Phylogenetic Analysis of R2R3-MYB Family Genes in Tetrastigma hemsleyanum Diels et Gilg and Roles of ThMYB4 and ThMYB7 in Flavonoid Biosynthesis." Biomolecules 13, no. 3 (2023): 531. http://dx.doi.org/10.3390/biom13030531.

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Tetrastigma hemsleyanum Diels et Gilg (T. hemsleyanum) is an extensively used Chinese folk herb with multiple bioactivities. Among these bioactivities, flavonoids are recognized as the representative active ingredients. We previously found an elevated accumulation of flavonoids in T. hemsleyanum under water stress; however, the mechanism remains unclear. R2R3-MYB transcription factors play vital roles in the plant response to environmental stress and the regulation of secondary metabolites. Herein, a systematic transcriptome identification of R2R3-MYB family genes under water stress in T. hems

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Rahayu, Dyah Utami Cahyaning, Regina Ainunnisa Hakim, Shofi Airiza Mawarni, and Andhina Rizkya Satriani. "Indonesian Cinnamon (Cinnamomum burmannii): Extraction, Flavonoid Content, Antioxidant Activity, and Stability in the Presence of Ascorbic Acid." Cosmetics 9, no. 3 (2022): 57. http://dx.doi.org/10.3390/cosmetics9030057.

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Cinnamon (Cinnamomum burmannii) is a potential source used in cosmetics to prevent skin aging due to its flavonoids and antioxidant properties. This research aims to determine the best solvent for extracting flavonoids, to conduct a large-scale isolation of flavonoids, and to evaluate the effect of ascorbic acid and temperature on the extract’s stability for 16 weeks. Various solvents for small-scale extraction were screened based on the polarity index, and one of the best for use in large-scale maceration was selected based on the AlCl3 colorimetric flavonoid content and DPPH antioxidant acti

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Ram, Baga, and Navdeep S. Bains. "Antimicrobial activity of flavonoids from in vitro tissue culture and plant parts of two plant species of Western Rajasthan." Indian Journal of Pharmaceutical and Biological Research 2, no. 02 (2014): 18–21. http://dx.doi.org/10.30750/ijpbr.2.2.4.

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Extract of flavonoids from plant parts and callus tissues of Glinus lotoides (molluginaceae) and Psoralea odorata (fabaceae) were screened against microbes’ viz., Bacillus cerus, Escherchia coli, Salmonella typhimurium, Staphylococcus aureus and Candida albicans adopting disc diffusion method. Results were compared with the zone of inhibition produced by commercially available standard antibiotics. Maximum activity was observed in flavonoid of callus tissue as compared to plant parts of both plant species.

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Bambrana, Vanishree, Dayanand Cd, and Sheela Sr. "EVALUATION OF XANTHINE OXIDASE INHIBITORY ACTIVITY BY FLAVONOIDS FROM PONGAMIA PINNATA LINN." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 360. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.16303.

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ABSTRACTObjective: Flavonoids from the crude seeds extract of Pongamia pinnata L., dried fruit powder of Morinda citrifolia L., bark of Mangifera indica L., andrhizome of Zingiber officinale Rosc. were screened for xanthine oxidase (XO) inhibition at different concentration. The inhibitory potential of quercetinand allopurinol were used for the determination of 50% inhibitory concentration (IC50) and Ki values.Methods: Isolation of flavonoids from the plant extracts was processed by column chromatography and tested for XO inhibitory activity in the rangeof 6-800 μg/ml.Results: The results demo

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Krishna Kumar, H. N., and Jyoti Bala Chauh. "Phytochemical screening and anticancer activity of leaf extracts of Physalis minima." JOURNAL OF ADVANCES IN NATURAL SCIENCES 3, no. 2 (2016): 283–87. http://dx.doi.org/10.24297/jns.v3i2.3971.

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Physalis minima a medicinally important plant of the family Solanaceae has been screened for its anticancer activity. The results of preliminary phytochemical screening of the leaf extract revealed the presence of flavonoids, alkaloids, tannins, saponins, steroids, cardiac glycosides, reducing sugars and terpenoids. Determination of total phenolic contents revealed that methanolic extract showed 78.3 mg/g of phenolic compounds. Evaluation of total flavonoid content showed 61.3 mg/g of flavonoid. It was found that the % viability of HeLa cell line & Hep2 cell line are 80% & 71.8% respec

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AlZahrani, Wejdan M., Shareefa A. AlGhamdi, Sayed S. Sohrab, and Mohd Rehan. "Investigating a Library of Flavonoids as Potential Inhibitors of a Cancer Therapeutic Target MEK2 Using in Silico Methods." International Journal of Molecular Sciences 24, no. 5 (2023): 4446. http://dx.doi.org/10.3390/ijms24054446.

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The second leading cause of death in the world is cancer. Mitogen-activated protein kinase (MAPK) and extracellular signal-regulated protein kinase (ERK) 1 and 2 (MEK1/2) stand out among the different anticancer therapeutic targets. Many MEK1/2 inhibitors are approved and widely used as anticancer drugs. The class of natural compounds known as flavonoids is well-known for their therapeutic potential. In this study, we focus on discovering novel inhibitors of MEK2 from flavonoids using virtual screening, molecular docking analyses, pharmacokinetic prediction, and molecular dynamics (MD) simulat

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Kontagora, G. F., N. Lawal, D. A. Adebote, B. Kamba, M. I. Nafiu, and A. I. Jufare. "Some preliminary phytochemical screening and assessment of four solvents extracts of button weed (Borreria verticillata)." Journal of Applied Sciences and Environmental Management 24, no. 12 (2021): 2085–88. http://dx.doi.org/10.4314/jasem.v24i12.12.

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Borreria vertcillata is a woody perennial shrub with false-button weedy herb belonging to the family (Rubiaceae), used for treating/curing various forms of diseases across the world since ancient times. Qualitative phytochemical screening of Borreria vertcillata pulverized whole plant was carried out using four different solvent extracts (N-hexane, chloroform, ethyl-acetate and methanol). The phytochemicals screeened contained alkaloids, triterpenes, flavonoids, glycosides, tannins, saponnins, anthraquinones and steroids. The extracts were then screened for the presence of some phytochemicals

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Wang, Tao, Fengjiao Zhang, Weibing Zhuang, Xiaochun Shu, and Zhong Wang. "Metabolic Variations of Flavonoids in Leaves of T. media and T. mairei Obtained by UPLC-ESI-MS/MS." Molecules 24, no. 18 (2019): 3323. http://dx.doi.org/10.3390/molecules24183323.

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The needles of Taxus species contain a large number of bioactive compounds, such as flavonoids. In the present study, the total flavonoid content in leaves of Taxus media and Taxus mairei was 19.953 and 14.464 mg/g, respectively. A total of 197 flavonoid metabolites (70 flavones, 42 flavonols, 26 flavone C-glycosides, 20 flavanones, 15 anthocyanins, 13 isoflavones, 6 flavonolignans, and 5 proanthocyanidins) were identified for the first time by a widely targeted Ultra Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS/MS) method within the two Taxus

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Ren, Chaoxiang, Chao Chen, Shuai Dong, et al. "Integrated metabolomics and transcriptome analysis on flavonoid biosynthesis in flowers of safflower (Carthamus tinctorius L.) during colour-transition." PeerJ 10 (June 22, 2022): e13591. http://dx.doi.org/10.7717/peerj.13591.

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Background Safflower (Carthamus tinctorius L.), well known for its flower, is widely used as a dye and traditional Chinese medicine. Flavonoids, especially flavonoid glycosides, are the main pigments and active components. However, their biosynthesis is largely unknown. Interestingly, the colour of flowers in safflower changed from yellow to red during flower development, while much of the gene and chemical bases during colour transition are unclear. Methods In this research, widely targeted metabolomics and transcriptomics were used to elucidate the changes in flavonoid biosynthesis from the

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Bhixavatimath, Prabhulingayya S., Yasmeen Maniyar, Akram Naikawadi, and Vijayakumar D. "EVALUATION OF POTENTIAL ANTIMICROBIAL ACTIVITY OF SYNTHETIC FLAVONOIDS." Journal of Biomedical and Pharmaceutical Research 10, no. 1 (2021): 76–82. http://dx.doi.org/10.32553/jbpr.v10i1.841.

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Introduction: In recent times, most of the currently available antimicrobial agents have developed resistance. Extensive pharmacological activities including bactericidal and bacteriostatic nature of flavonoids, made them as priority agents in this aspect of research study. Synthetic flavonoids such as hydroxy thiophen derivatives were considered to evaluate for antimicrobial activity in this study.  Objective: The present study involves the analysis for antimicrobial activity of thiophen substituted synthetic flavonoids. Methods: Claisen-Schmidt method of condensation fallowed by

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James, Jainey Puthenveettil, Pankaj Kumar, Abhishek Kumar, Katte Ishwar Bhat, and Chakrakodi Shashidhara Shastry. "In Silico Anticancer Evaluation, Molecular Docking and Pharmacophore Modeling of Flavonoids against Various Cancer Targets." Letters in Drug Design & Discovery 17, no. 12 (2020): 1485–501. http://dx.doi.org/10.2174/1570180817999200730164222.

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Background: Designing and development of molecules for cancer treatment useful and with no side effects are a big challenge for the researchers in the field of drug discovery. The use of phytochemicals for chemoprevention is gaining more advantages, and intake of flavonoids has proved to reduce the occurrence of various cancers. Objectives: The present study was focused on selecting eight flavonoids and study them by in silico methods to analyse the interactions, affinity and pharmacophoric features that participate in the interactions between the flavonoid and the active sites of different ca

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Ruiz-Iglesias, Patricia, Abril Gorgori-González, Malén Massot-Cladera, Margarida Castell, and Francisco J. Pérez-Cano. "Does Flavonoid Consumption Improve Exercise Performance? Is It Related to Changes in the Immune System and Inflammatory Biomarkers? A Systematic Review of Clinical Studies since 2005." Nutrients 13, no. 4 (2021): 1132. http://dx.doi.org/10.3390/nu13041132.

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Flavonoids are attracting increasing attention due to their antioxidant, cardioprotective, and immunomodulatory properties. Nevertheless, little is known about their role in exercise performance in association with immune function. This systematic review firstly aimed to shed light on the ergogenic potential of flavonoids. A search strategy was run using SCOPUS database. The returned studies were screened by prespecified eligibility criteria, including intervention lasting at least one week and performance objectively quantified, among others. Fifty-one studies (54 articles) met the inclusion

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Mutiah, Roihatul, Tanaya Jati Dharma Dewi, Arief Suryadinata, and Kesimira Qonita. "Inhibition of Human Epidermal Growth Factor Receptor-2 (HER-2) from Pomelo (Citrus maxima) Flavonoid Compounds: an In Silico Approach." Indonesian Journal of Cancer Chemoprevention 12, no. 3 (2022): 148. http://dx.doi.org/10.14499/indonesianjcanchemoprev12iss3pp148-160.

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Citrus maxima or pomelo is a plant that has potential as an anticancer because it contains flavonoids. One of the targets of breast anticancer receptors is the HER-2 protein. This research aims to determine the anticancer activity, the toxicity of the compound, and the prediction of physicochemical properties of flavonoids contained in Citrus maxima through in silico approach. Flavonoid compounds were screened using SwissADME with Lipinski's rule of five, Torsion, TPSA, and P-Gp Non-Substrate. Compounds that passed the screening were carried out molecular docking to the HER-2 receptor (PDB ID:

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AlZahrani, Wejdan M., Shareefa A. AlGhamdi, Torki A. Zughaibi, and Mohd Rehan. "Exploring the Natural Compounds in Flavonoids for Their Potential Inhibition of Cancer Therapeutic Target MEK1 Using Computational Methods." Pharmaceuticals 15, no. 2 (2022): 195. http://dx.doi.org/10.3390/ph15020195.

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The Mitogen-Activated Protein Kinase (MAPK) signaling pathway plays an important role in cancer cell proliferation and survival. MAPKs’ protein kinases MEK1/2 serve as important targets in drug designing against cancer. The natural compounds’ flavonoids are known for their anticancer activity. This study aims to explore flavonoids for their inhibition ability, targeting MEK1 using virtual screening, molecular docking, ADMET prediction, and molecular dynamics (MD) simulations. Flavonoids (n = 1289) were virtually screened using molecular docking and have revealed possible inhibitors of MEK1. Th

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I, Vinibha Rajakumari, Kalyanaraman Rajagopal, Sriraman V, Vanitha V, and Mohanasundaram S. "Various chemical groups produced by endophytic fungi isolated from the Calotropis procera- A pharmaceutically important xerophytic plant." International Journal of Research in Pharmaceutical Sciences 9, no. 1 (2018): 82. http://dx.doi.org/10.26452/ijrps.v9i1.1188.

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In the present study leaf tissue of host plant Calotropis procera was screened for the presence of endophytic fungi. The crude extract of the isolated endophytic fungi was tested for various chemical groups like alkaloids, flavonoids, diterpenoids and phenols. Our study showed the presence of 25 endophytic fungi isolated from the leaf tissue which constituted15 Hyphomycetes, 3 Ascomycetes, 3 Coelomycetes and 4 sterile forms. The qualitative analysis in all the 25 isolates showed the presence of alkaloid, phenol in 23 fungi, flavonoid in 19 and diterpenoids in 18 fungi. Fifteen endophytic fungi

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Innok, Wansiri, Thanyada Rungrotmongkol, and Panita Kongsune. "Insights into Binding Affinity of Flavonoid Compounds from Thai Herbs against 2009 H1N1 Hemagglutinin." Trends in Sciences 19, no. 5 (2022): 2689. http://dx.doi.org/10.48048/tis.2022.2689.

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Outbreak of influenza virus is one of serious concerns for public health. Hemagglutinin (HA), a spike-shaped glycoprotein on the viral surface, plays an important role during the early stage of influenza infection. In the present work, a set of flavonoids were screened against 2009 H1N1 HA by computational chemistry techniques. Among 35 flavonoids, the docking results showed that the epicatechin gallate (ECG) and puerarin exhibited a good binding affinity towards 2009 H1N1 HA. These 2 compounds were then studied by all-atom molecular dynamics (MD) simulations. The predicted binding free energy

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Fatiqin, Awalul, Hanif Amrulloh, Ike Apriani, et al. "A Comparative Study on Phytochemical Screening and Antioxidant Activity of Aqueous Extract from Various Parts of Moringa oleifera." Indonesian Journal of Natural Pigments 3, no. 2 (2021): 43. http://dx.doi.org/10.33479/ijnp.2021.03.2.43.

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In this work, we reported a comparative study on the phytochemical screening and antioxidant activity of aqueous extract from different parts of Moringa oleifera plant, i.e. leaves, twigs, stem barks, and woods. The phytochemical content of each extract was screened through qualitative analysis and followed by quantitative analysis for the determination of total phenolic content and total flavonoid content. The results showed that different parts of Moringa oleifera plant would give different extracted natural products. Either leaf or twig part of Moringa oleifera contained alkaloids, flavonoi

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Yasir, Muhammad, Jinyoung Park, Eun-Taek Han, et al. "Investigation of Flavonoid Scaffolds as DAX1 Inhibitors against Ewing Sarcoma through Pharmacoinformatic and Dynamic Simulation Studies." International Journal of Molecular Sciences 24, no. 11 (2023): 9332. http://dx.doi.org/10.3390/ijms24119332.

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Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX1) is an orphan nuclear receptor encoded by the NR0B1 gene. The functional study showed that DAX1 is a physiologically significant target for EWS/FLI1-mediated oncogenesis, particularly Ewing Sarcoma (ES). In this study, a three-dimensional DAX1 structure was modeled by employing a homology modeling approach. Furthermore, the network analysis of genes involved in Ewing Sarcoma was also carried out to evaluate the association of DAX1 and other genes with ES. Moreover, a molecular docking study was car

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Liesl Maria Fernandes e Mendonça, Arun B. Joshi, Anant V. Bhandarkar, and Himanshu Joshi. "Evaluation of antioxidant property and anticancer prospective of the leaf extract and biofractions of Bauhinia foveolata Dalzell – A native of the Indian Western Ghats." International Journal of Research in Pharmaceutical Sciences 12, no. 3 (2021): 1886–94. http://dx.doi.org/10.26452/ijrps.v12i3.4789.

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The current study was designed to evaluate the antioxidant and anticancer potential of ethanolic leaf extract of Bauhinia foveolata Dalzell. (EEBF) and its toluene, ethyl acetate and methanolic biofractions viz., TFBF, EFBF and MFBF. Phytoconstituents were screened by adopting established procedures. Total phenolic and flavonoid content were assessed spectrophotometrically. In vitro antioxidant activity was assayed using DPPH (2,2-diphenyl-1-picrylhydrazyl), hydrogen peroxide and nitric oxide as free radicals, whereas anticancer activity was evaluated using sulforhodamine B assay. EEBF showed

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Singhal, Garima, Arpita Roy, and Navneeta Bharadvaja. "In-silico study on plant determined flavonoids compounds for the synthetic medications against breast cancer growth." Journal of Ayurvedic and Herbal Medicine 3, no. 3 (2017): 116–21. http://dx.doi.org/10.31254/jahm.2017.3303.

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Breast cancer is one of the genuine wellbeing worries in India bringing about the most elevated death rate in females, which happens because of uncontrolled cell division and can be metastasize to different parts of the human body, and different medications are accessible to its cure. Drugs like Tamoxifen and Herceptin can cure breast cancer however these medications have their unsafe impacts on human body. This study deals with the docking, toxicity, bioactivity and ADME expectation of flavonoids compounds with HER2 and estrogen receptor, to limit the utilization of existing medications. Lipi

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Tang, Zizhong, Yinsheng Wang, Jingyu Yang, et al. "Isolation and identification of flavonoid-producing endophytic fungi from medicinal plant Conyza blinii H.Lév that exhibit higher antioxidant and antibacterial activities." PeerJ 8 (April 15, 2020): e8978. http://dx.doi.org/10.7717/peerj.8978.

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Background Conyza blinii H. Lév is a medicinal plant that has a variety of pharmacological activities, but its study is at a standstill due to the shortage of resources. Method This study utilized the surface sterilization method to isolate endophytic fungi, and they were preliminarily identified by morphology. Flavonoid-producing strains were screened by NaNO2-Al(NO)3 colorimetry and further identified by the ITS sequence. Additionally, we used five antioxidant assays (DPPH, Hydroxyl radical, ABTS, FRAP and T-AOC assays) to systematically evaluate the antioxidant capacity of total flavonoids

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Yuan, Jiahuan, Nan Wu, Zhichen Cai, et al. "Metabolite Profiling and Transcriptome Analysis Explain the Difference in Accumulation of Bioactive Constituents in Taxilli Herba from Two Hosts." Genes 14, no. 5 (2023): 1040. http://dx.doi.org/10.3390/genes14051040.

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Taxilli Herba (TH) is a semi-parasitic herb and the host is a key factor affecting its quality. Flavonoids are the main bioactive constituents in TH. However, studies on the difference in accumulation of flavonoids in TH from different hosts are vacant. In this study, integrated transcriptomic and metabolomic analyses were performed on TH from Morus alba L. (SS) and Liquidambar formosana Hance (FXS) to investigate the relationship between the regulation of gene expression and the accumulation of bioactive constituents. The results showed that a total of 3319 differentially expressed genes (DEG

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Lathiff, Siti Mariam Abdul, Noraini Jemaon, Siti Awanis Abdullah, and Shajarahtunnur Jamil. "Flavonoids from Artocarpus anisophyllus and their Bioactivities." Natural Product Communications 10, no. 3 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000305.

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Two new prenylated flavonoids, 4′,5-dihydroxy-6,7-(2,2-dimethylpyrano)-2′-methoxy-8-γ,γ-dimethylallylflavone 1 and 3′-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4′-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artocarpin 6, chaplashin 7 and cycloartocarpin 8 were isolated for the first time from the leaves and the heartwoods of Artocarpus anisophyllus Miq. The structures of isolated flavonoids were elucidated spectroscopically using 1D and 2D NMR, FTIR, MS, UV and also by comparison with literature data. These flavonoids were scre

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Giri, Hari, and Meena Rajbhandari. "Phytochemical Evaluation of Some Medicinal Plants of Puthan District of Nepal." Nepal Journal of Science and Technology 19, no. 1 (2020): 97–106. http://dx.doi.org/10.3126/njst.v19i1.29789.

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Different parts of eleven medicinal plants used in the traditional medicine in Puthan district were collected. Three different extracts, methanol, 50% aqueous methanoland 70% aqueous acetone extractswere prepared for each plant material. The methanol extractswere screened for the presence of different classes of phytochemicals. Total phenolic andflavonoid content, as well as DPPH freeradical scavenging activity, were evaluated. All the investigated extracts contain a high amount of phenolics and flavonoids.The highest amount of phenolicsand flavonoids were detected in the methanolextract of ba

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Lu, Jinkai, Xinyu Mao, Yuan Xu, Sian Liu, and Li Wang. "MicroRNA Identification and Integrated Network Analyses for Age-Dependent Flavonoid Biosynthesis in Ginkgo biloba." Forests 14, no. 9 (2023): 1706. http://dx.doi.org/10.3390/f14091706.

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Ginkgo biloba leaves contain abundant flavonoids, and flavonoid accumulation is affected by age. MicroRNAs (miRNAs) play an important role in the plant aging pathway. However, the miRNAs involved in flavonoid biosynthesis related to age in G. biloba have rarely been studied. In this study, we compared 1-, 4-, and 7-year-old ginkgo seedings and found a significant decrease in the content of quercetin, kaempferol, and total flavonol aglycones with age. We then profiled miRNAs in G. biloba through high-throughput sequencing on leaf samples of 1-, 4-, and 7-year-old ginkgo. GO and KEGG analyses su

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Bajrai, Leena Hussein, Aiah M. Khateb, Maha M. Alawi, et al. "Glycosylated Flavonoid Compounds as Potent CYP121 Inhibitors of Mycobacterium tuberculosis." Biomolecules 12, no. 10 (2022): 1356. http://dx.doi.org/10.3390/biom12101356.

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Due to the concerning rise in the number of multiple- and prolonged-drug-resistant (MDR and XDR) Mycobacterium tuberculosis (Mtb) strains, unprecedented demand has been created to design and develop novel therapeutic drugs with higher efficacy and safety. In this study, with a focused view on implementing an in silico drug design pipeline, a diverse set of glycosylated flavonoids were screened against the Mtb cytochrome-P450 enzyme 121 (CYP121), which is established as an approved drug target for the treatment of Mtb infection. A total of 148 glycosylated flavonoids were screened using structu

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Krishna Swaroop, Akey, Esakkimuthukumar M, Patnaik S.K, et al. "Dual Modulation of IL-6 Pathway by Flavonoid Metal Complex as Immune Boosters for SARS-CoV-2 Therapy." ECS Transactions 107, no. 1 (2022): 9771–79. http://dx.doi.org/10.1149/10701.9771ecst.

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It is observed that Cytokine Release Syndrome (CRS) is one of the major causes of the death of several COVID-19 patients. Though several cytokines are involved in CRS, IL-6 modulation plays a major role. We aim to develop new flavonoid metal complexes as immune boosters targeting IL-6 for SARS-CoV-2 treatment. To find potential flavonoids, PyRx 0.9 tool has been used to dock 152 secondary plant metabolites against IL-6 (PDB ID: 1ALU). The top scorer flavonoid (quercetin) was made into quercetin zinc ascorbic acid metal complex (QM-1). The in-vitro hemolytic research revealed a modest hemolytic

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Hou, Huimin, Ying Wang, Chunshi Li, Jian Wang, and Yanli Cao. "Dipeptidyl Peptidase-4 Is a Target Protein of Epigallocatechin-3-Gallate." BioMed Research International 2020 (February 11, 2020): 1–9. http://dx.doi.org/10.1155/2020/5370759.

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Epigallocatechin-3-gallate (EGCG), a major active ingredient in green tea, has various health benefits. It affects glucose metabolism, but the mechanism is not well understood. This study aimed to identify targets of EGCG related to glucose metabolism. The core fragment of EGCG is a flavonoid. The flavonoid scaffold was used as a substructure to find proteins cocrystallized with flavonoids in the Protein Data Bank. The proteins identified were screened in PubMed for known relationships with diabetes. Dipeptidyl peptidase-4 (DPP4; PDB 5J3J) was identified following this approach. By molecular d

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Ram, Menavath Tulasi Naik, Sai Kushal Gunturu, Afzal Basha Shaik, Yadlapalli Jaya Prasanth Babu, and Sardena Siyonu Kumari. "Studies of Antibacterial Activity of the Seed Extract of Solanum surattense Burm. F ." Journal of Pharmaceutical Research 21, no. 4 (2022): 123–27. http://dx.doi.org/10.18579/jopcr/v21i4.22.24.

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Crude Flavonoids extracted from crushed seeds of dried ripe fruits of Solanum surattense Burm F. were screened for antimicrobial activity against two bacteria – Streptococcus mutans and Aggregatibacter actinomycetemcomitans – which were found to be major contributers for occurrence of Dental caries. Minimum inhibitory concentration, Minimum bactericidal concentration, and Time Kill curve of the extract against each sensitive test pathogen, were evaluated. The flavonoid extract showed good antimicrobial activity against Streptococcus mutans than towards Aggregatibacter actinomycetemcomitans. MI

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Zeng, Xiaofeng, Xiao Wang, Yanling Zeng, Jinbo Hou, and Zhiming Liu. "Flavonoid Metabolome-Based Active Ingredient Mining and Callus Induction in Catalpa bungei C. A. Mey." Forests 14, no. 9 (2023): 1814. http://dx.doi.org/10.3390/f14091814.

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Catalpa bungei C. A. Mey is a unique and precious multi-purpose tree species that possesses great timber-related, ornamental and medicinal values. In this study, MS, N6 and DKW were used as basic media, and different concentrations of 6-BA and NAA were added for callus induction. The induction rate and total flavonoid content of callus tissue showed that the best callus induction medium was DKW + 2.0 mg·L−1 6-BA + 0.5–1.0 mg·L−1 NAA. The leaves of different bark phenotypes of C. bungei C. A. Mey and the callus tissue extracted from young leaves of C. bungei C. A. Mey were used as experimental

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Hossain, M. S., S. Parvin, S. Dutta, M. S. I. Mahbub, and M. E. Islam. "Studies on In Vitro Antioxidant Activity of Methanolic Extract and Fractions of Ficus Hispida Lin. Fruits." Journal of Scientific Research 8, no. 3 (2016): 371–80. http://dx.doi.org/10.3329/jsr.v8i3.26711.

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The present study was designed to confirm the traditional use of the fruits of Ficus hispida Linn. (Moraceae) as an antioxidant agent. Fruits of the plant extracted with methanol and crude methanol extract (CME) were further fractionated with n-hexane, chloroform, and ethyl acetate. All the fractions, n-hexane (NHF), chloroform (CHF), ethyl acetate (EAF), aqueous (AQF) and CME were preliminary screened for in vitro antioxidant activity and total phenolic and total flavonoid content. In DPPH radical scavenging assay, CME exhibited highest scavenging activity (IC50 = 11.20 µg/mL) as compared to

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Middha, Sushil Kumar, Talambedu Usha, and Veena Pande. "HPLC Evaluation of Phenolic Profile, Nutritive Content, and Antioxidant Capacity of Extracts Obtained fromPunica granatumFruit Peel." Advances in Pharmacological Sciences 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/296236.

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This study revealed polyphenolic content, nutritive content, antioxidant activity, and phenolic profile of methanol and aqueous extracts ofPunica granatumpeel extract. For this, extracts were screened for possible antioxidant activities by free radical scavenging activity (DPPH), hydrogen peroxide scavenging activity and ferric-reducing antioxidant power (FRAP) assays. The total phenolics and flavonoid recovered by methanolic (MPE) and the water extract (AQPE) were ranged from 185 ± 12.45 to 298.00 ± 24.86 mg GAE (gallic acid equivalents)/gm and 23.05 ± 1.54 to 49.8 ± 2.14 quercetin (QE) mg/g,

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Dilshad, Erum, Maria Idrees, Bareera Sajid, Anum Munir, and Sahar Fazal. "Non-Toxic Flavonoids of Artemisia annua can be used as Anti-Cancer Compounds: A Computational Analysis." Life and Science 3, no. 4 (2022): 12. http://dx.doi.org/10.37185/lns.1.1.195.

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Objective: To identify potential flavonoids of Artemisia annua effective against cancer using computationalapproaches.Study Design: Computational approaches were used to predict the anticancer activity of flavonoids throughCDRUG, comparing it with the standard anticancer drug, followed by determining physiochemical propertiesand toxicity prediction of the selected flavonoids.Place and Duration of Study: The study was carried out at Department of Bioinformatics and Biosciences ofCapital University of Science and Technology (CUST) Islamabad, from December 2017 to July 2018.Materials and Methods:

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Sannigrahi, Santanu, Upal Kanti Mazumder, Arijit Mondal, Dilipkumar Pal, Silpi Lipsa Mishra, and Souvik Roy. "Flavonoids of Enhydra Fluctuans Exhibit Anticancer Activity against Ehrlich's Ascites Carcinoma in Mice." Natural Product Communications 5, no. 8 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500818.

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Flavonoids obtained from Enhydra fluctuans (FEF) were screened for anticancer activity against Ehrlich's ascites carcinoma (EAC) bearing Swiss albino mice. The anticancer activity was assessed by measuring the tumor growth response, percentage increase of life span, hematological parameters, lipid peroxidation, and antioxidant enzyme activity, like GSH and CAT. Two flavonoids, baicalein 7- O-glucoside and baicalein 7- O-diglucoside, were isolated from the ethyl acetate fraction. Treatment with FEF caused a significant decrease in the tumor cell volume and increase of life span. All the hematol

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Wang, Pan, Tao Hou, Fangfang Xu, et al. "Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles." International Journal of Molecular Sciences 23, no. 18 (2022): 10747. http://dx.doi.org/10.3390/ijms231810747.

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ATP citrate lyase (ACLY) is a key enzyme in glucolipid metabolism and its aberrantly high expression is closely associated with various cancers, hyperlipemia and atherosclerotic cardiovascular diseases. Prospects of ACLY inhibitors as treatments of these diseases are excellent. To date, flavonoids have not been extensively reported as ACLY inhibitors. In our study, 138 flavonoids were screened and 21 of them were subjected to concentration–response curves. A remarkable structure–activity relationship (SAR) trend was found: ortho-dihydroxyphenyl and a conjugated system maintained by a pyrone ri

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Vergallo, Cristian, Elisa Panzarini, and Luciana Dini. "High performance liquid chromatographic profiling of antioxidant and antidiabetic flavonoids purified from Azadirachta indica (neem) leaf ethanolic extract." Pure and Applied Chemistry 91, no. 10 (2019): 1631–40. http://dx.doi.org/10.1515/pac-2018-1221.

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Abstract Azadirachta indica (neem) is a tropical and semi-tropical tree native to the whole Indian subcontinent. Neem leaves are rich in flavonoids, which exhibit important pharmacological activities targeting almost all human organs. In order to produce a purified extract of neem leaves enriched of antioxidant and antidiabetic flavonoids, the ethanolic extract of neem leaves has been further undergone to liquid-liquid extractions by using three different organic solvents, i.e. dichloromethane, n-butanol and ethyl acetate. Qualitative and quantitative analyses were performed on the extracts ob

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Mohan, Baskar, Vadamalai Krishnan K, and Muthuraman K. "Evaluation of Pterospermum suberifolium L. Willd Leaves for the Phytochemical Constituents and their in vitro Activities." International Journal of Ayurvedic Medicine 11, no. 3 (2020): 547–53. http://dx.doi.org/10.47552/ijam.v11i3.1541.

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The present study was intended to investigate the phytochemical constituents present in the leaves of Pterospermum suberifolium L. WILLD and the in vitro antioxidant and antimicrobial properties of the various extracts prepared by different solvents including aqueous, methanol, ethyl acetate and hexane. The crude extracts were screened for the presence of various phytochemical constituents and the presence of phenols, tannins, flavonoids, saponins and alkaloids were ascertained. The quantitative estimation of phenols and flavonoids were determined. The antioxidant activities of the plant leaf

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Zhong, Bin, Xianhua Huang, Yizhou Zheng, Xiaohua Guo, and Longhuo Wu. "The discovery and development of transthyretin amyloidogenesis inhibitors: what are the lessons?" Future Medicinal Chemistry 13, no. 23 (2021): 2083–105. http://dx.doi.org/10.4155/fmc-2021-0248.

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Transthyretin (TTR) is associated with several human amyloid diseases. Various kinetic stabilizers have been developed to inhibit the dissociation of TTR tetramer and the formation of amyloid fibrils. Most of them are bisaryl derivatives, natural flavonoids, crown ethers and carborans. In this review article, we focus on TTR tetramer stabilizers, genetic therapeutic approaches and fibril remodelers. The binding modes of typical bisaryl derivatives, natural flavonoids, crown ethers and carborans are discussed. Based on knowledge of the binding of thyroxine to TTR tetramer, many stabilizers have

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Yang, Yuangui, Yanli Zhao, Zhitian Zuo, and Yuanzhong Wang. "Determination of Total Flavonoids for Paris Polyphylla Var. Yunnanensis in Different Geographical Origins Using UV and FT-IR Spectroscopy." Journal of AOAC INTERNATIONAL 102, no. 2 (2019): 457–64. http://dx.doi.org/10.5740/jaoacint.18-0188.

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Abstract Background: Paris polyphylla var. Yunnanensis (PPY) is used in the clinical treatment of tumors, hemorrhages, and anthelmintic. Objective: The aim of this study is to determine total flavonoids of PPY in the Yunnan and Guizhou Provinces, China. Methods: In this study, total flavonoids were determined by UV spectrophotometry at first. Then, Fourier transform mid-infrared (FT-IR) based on various pretreatments include standard normal variate (SNV), first derivative (FD), second derivative (SD), Savitzky-Golay (SG), and orthogonal signal correction (OSC) were investigated. In addition, s

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Saoudi, Soulef, Seddik Khennouf, and Nozha Mayouf. "Phenolic compounds of Pyrus communis fruit methanol extract and evaluation of antioxidant activity." Journal of Drug Delivery and Therapeutics 10, no. 6 (2020): 106–9. http://dx.doi.org/10.22270/jddt.v10i6.4574.

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Pear (Pyrus communis.) fruit is popular among consumers due to its high nutritive value, good taste and low caloric level. This study examined polyphenolic content, antioxidant activity and phenolic profile of methanol extract of Pyrus communis fruit. Extract were screened for possible antioxidant activities using free radical scavenging activity of DPPH, hydroxyl scavenging activity and reducing power assays. This extract contain high polyphenolic and flavonoids contents (172.5 ± 0.005 mg GAE/g dry extract and 5.34 ± 0.003mg QE/g dry extract) respectively. Similarly, this extract showed high

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Chaikhong, Kamonwan, Sawarin Chumpolphant, Panthakarn Rangsinth, et al. "Antioxidant and Anti-Skin Aging Potential of Selected Thai Plants: In Vitro Evaluation and In Silico Target Prediction." Plants 12, no. 1 (2022): 65. http://dx.doi.org/10.3390/plants12010065.

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The skin is the largest organ that performs a variety of the body’s essential functions. Impairment of skin structure and functions during the aging process might severely impact our health and well-being. Extensive evidence suggests that reactive oxygen species play a fundamental role in skin aging through the activation of the related degradative enzymes. Here, the 16 Thai medicinal plant species were screened for their potential anti-skin aging properties. All extracts were investigated for total phenolic and flavonoid contents, antioxidant, anti-elastase, and anti-tyrosinase activities, as

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Pillai, Bhinu V. S., and Sanjay Swarup. "Elucidation of the Flavonoid Catabolism Pathway in Pseudomonas putida PML2 by Comparative Metabolic Profiling." Applied and Environmental Microbiology 68, no. 1 (2002): 143–51. http://dx.doi.org/10.1128/aem.68.1.143-151.2002.

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ABSTRACT Flavonoids are 15-carbon plant secondary metabolites exuded in the rhizosphere that hosts several flavonoid-degrading bacteria. We studied flavonoid catabolism in a plant growth-promoting rhizobacterial strain of Pseudomonas by using a combination of biochemical and genetic approaches. Transposants carrying mini-Tn5gfp insertions were screened for flavonoid auxotrophy, and these mutant strains were found to be unable to grow in the flavonols naringenin and quercetin, while their growth in glycerol was comparable to that of the parental strain. In order to understand flavonoid cataboli

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Tran, Pham Linh Phuong, and Hong Phu Le. "Plant Flavonoids as Potential Natural Antioxidants in Phytocosmetics." Journal of Technical Education Science, no. 70B (June 28, 2022): 86–93. http://dx.doi.org/10.54644/jte.70b.2022.1172.

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Phytocosmetics, the sub-discipline of cosmetology which primarily uses plant and plant extracts in beauty treatments, has been endorsed for thousands of years. After a period of time being pushed aside by an enormous wave of interest in synthetic products, phytocosmetics is slowly but surely returning to its propitious moment. Botanical compounds, among which flavonoids are highlighted, are being recognized for their biological activities – namely antioxidant, anti-aging, anti-inflammatory, anti-microbial and photoprotective activities. The purpose of this paper is to review updates in the ext

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Hassan, Yusuf, and Magaji Ilu Barde. "Phytochemical Screening and Antioxidant Potential of Selected Nigerian Vegetables." International Annals of Science 8, no. 1 (2019): 12–16. http://dx.doi.org/10.21467/ias.8.1.12-16.

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Reducing power activities of ten vegetables commonly consumed in Katsina State, Nigeria have been assessed with the view of establishing their antioxidant capacities. Preliminary, the phytochemicals of the individual plants were screened, and it was found that various constituents were present. In particular, flavonoids and anthraquinones were found in Ficus glumosa which also appeared to demonstrate the best reducing power activity (4.898 at 25 mg/L).

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Dhakar, Ram Chand, Sunil Kumar Prajapati, Sheo Datta Maurya, et al. "Antioxidant Potential of Cordia dichotoma: A Review." Asian Journal of Dental and Health Sciences 1, no. 1 (2021): 19–23. http://dx.doi.org/10.22270/ajdhs.v1i1.6.

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Many plants of genus Cordia comprise of trees and shrubs are widely distributed in warmer regions and have been utilized in management of various diseases. Many phytochemicals like flavonoids, alkaloids, terpenes, tannins, and glyceridess having different activities were screened and isolated from different parts of C. dichotoma. Various important Pharmacological properties including Antiulcer, Contraceptives, anti-inflammatory, anthelmintic, analgesic, anticancer, Antioxidant, antimicrobial, hepatoprotective, antidiabetic and others have been well documented for this plant. C. dichotoma is a

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