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Relevant bibliographies by topics / Screening mechanisms

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Dissertations / Theses

Academic literature on the topic 'Screening mechanisms'

Author: Grafiati

Published: 23 November 2024

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Dissertations / Theses on the topic "Screening mechanisms"

1

Ruiz, Carmona Sergio. "Virtual screening for novel mechanisms of action: applications and methodological developments." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/400297.

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The main motivation of this thesis has been to validate, improve and develop new methods with respect to the ones available nowadays in the area of drug discovery, in order to be able to study more challenging targets in the near future that currently are out of our reach. As the productivity of the pharmaceutical industry is decreasing year after year over the last decades, the improvement of such methods would be a step forward. As we are mostly a computational lab, this thesis has focused on different computational approaches such as docking, molecular dynamics or chemoinformatics. O

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2

Jaworek, Karolina. "Screening for novel brain tumour initiation mechanisms at single cell resolution." Thesis, Bangor University, 2016. https://research.bangor.ac.uk/portal/en/theses/screening-for-novel-brain-tumour-initiation-mechanisms-at-single-cell-resolution(3bb44859-bc78-4fce-a7df-0f47d2dd6b4e).html.

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Despite progress in our understanding of origin and development of brain tumours, more efficient therapeutic approaches addressing the high recurrence rate and poor prognosis of brain tumours remain urgently needed, in particular for the most aggressive glioblastomas (GBMs). In this work, I used the Drosophila brain tumour (brat) mutant as an in vivo model to identify potential mechanisms of brain tumour initiation. The human brat orthologue, Trim3, has a conserved tumour suppressor function in GBMs. I applied a single cell transcriptome microarray technique to compare intermediate neural prog

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3

Wang, An Qi. "Screening of hepatoprotective constituents from herbal medicines and investigation on the underlying mechanisms." Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3690819.

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Ibaraki, Alicia. "Mechanisms that perpetuate health disparities: physician stereotypes & bias." Thesis, University of Oregon, 2018. http://hdl.handle.net/1794/23088.

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Purpose: Although Asian Americans are the only racial group for whom cancer is the leading cause of death, colorectal cancer screening is consistently lower than that of White Americans. Physicians also recommend colorectal cancer screening to Asian Americans at nearly half the rate as White Americans. This study tests a mechanism that may underlie low recommendation rates. I based my hypothesis on a conceptual model that integrates the literature on information processing and decision making with Asian American stereotypes. Methods: I conducted an online study of primary care physici

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Thistlethwaite, Rebecca Janette. "Identification of genetic variation in heat stress, genotype screening for and mechanisms of tolerance in wheat." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17339.

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Increasing global climatic variability will most likely increase temperatures and reduce annual rainfall in many cropping regions in the coming years. Changes in seasonal conditions are likely to have a significant impact on all food crops including wheat. This thesis aims to (1) identify genetic diversity for high temperature tolerance in bread wheat by evaluating a large number of genotypes across years and sowing dates, (2) evaluate a subset of germplasm was using different screening methods for heat tolerance (in-field controlled environment chambers and glasshouses) and (3) compare diffe

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6

Niegowski, Damian. "Structural biology of integral membrane proteins from methods to molecular mechanisms /." Doctoral thesis, Stockholm : Department of Biochemistry and Biophysics, Stockholm Univeristy, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-30069.

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7

Tsipa, Anastasia Isavella. "Understanding the factors and mechanisms that influence colorectal cancer screening uptake among socially deprived and non-deprived populations." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22226/.

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Colorectal cancer (CRC) is the second most common cause of cancer death in the UK. Since the introduction of the NHS Bowel Cancer Screening Programme CRC incidence and mortality rates have reduced, however, screening uptake in the overall population remains suboptimal and is disproportionately low among populations with low socioeconomic status (SES) and Black and Minority Ethnic populations. This thesis aimed to critically assess the available evidence of public health interventions to improve CRC screening and to examine the possible mechanisms of socioeconomic inequalities in CRC screening

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Piotrowska, Barbara. "Investigating the performance and underlying mechanisms of a novel screening measure for developmental dyslexia : implications for early identification." Thesis, Edinburgh Napier University, 2018. http://researchrepository.napier.ac.uk/Output/1253563.

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Developmental dyslexia is a common disorder affecting around 10% of the British population characterized by difficulties with reading despite adequate intelligence and education (IDA, 2007). Although most researchers and practitioners would agree that early identification is key in limiting negative consequences of reading problems, this is still difficult to achieve due to theoretical and practical inconsistencies in the field. This thesis focuses on investigating a novel, computer and tablet-based “dot-to-dot” (DtD) task that may aid the process of identification particularly in pre-reading

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9

Theodorou, Andria Soteri. "Screening and delineation of molecular mechanisms of action of HbF inducing agents for the treatment of β-thalassaemia". Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/screening-and-delineation-of-molecular-mechanisms-of-action-of-hbf-inducing-agents-for-the-treatment-of-thalassaemia(fbad43de-f2b2-49a1-980b-b6dfcc1a25c5).html.

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Current agents used for pharmacological reactivation of foetal haemoglobin (HbF) have limited application due to moderate therapeutic properties, variable patient response and potential cytotoxic effects. Therefore, identification of novel HbF inducing agents is still a major research goal to this day. Identification of new potential HbF inducers has been mainly based on screening of drug libraries. However, this approach has not been very successful in generating new promising agents. In the current project, I employed two approaches for identifying potential HbF inducers: 1) screening of age

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10

White, Rose. "Cyclin dependent kinase like 5 (CDKL5) mutation screening in Rett Syndrome and related clinical disorders." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28108.

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Rett Syndrome (RTT) is a severe neurodevelopmental disorder affecting almost exclusively females, with an incidence of 1 in 8,000 by 15 yrs of age. The disorder encompasses a wide spectrum of clinical phenotypes. Up to 95% of classical RTT and a lesser proportion (20%-60%) of those with atypical forms of RTT patients carry mutations in the X-linked MECP2 gene (Methyl-CpG binding protein 2), the first gene discovered to be associated with this disorder. Mutations in the X-Iinked CDKL5 gene (cyclin-dependent kinase-like 5) have also been found to cause atypical RTT (in particular, the ea

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