Academic literature on the topic 'Scrum (informatique)'

9589 Background: KRAS mutations are one of the common oncogene drivers in non-small cell lung cancer (NSCLC), and the development of several targeted drugs for KRAS-mutated NSCLC is now ongoing. However, the clinical impact of KRAS mutation subtypes or concomitant other gene mutations in NSCLC patients (pts) remains unclear. Methods: In a nationwide genomic screening project (LC-SCRUM-Japan), we have prospectively analyzed lung cancer pts for genetic alterations and tumor mutation burden (TMB) by next-generation sequencing system, and for PD-L1 expression by immunohistochemistry (22C3 antibody). The therapeutic efficacy and survival of KRAS-mutated non-squamous (non-sq) NSCLC pts were evaluated using a clinico-genomic database of the LC-SCRUM-Japan. Results: A total of 5166 non-sq NSCLC pts enrolled from 2015 to 2019. KRAS mutations were detected in 794 pts (15%; G12C/G12D/G12V/G12A/G13X/others = 232/186/165/66/61/84). Among the 794 pts, TMB and PD-L1 expression were analyzed in 128 and 79, respectively, and 218 received PD-1/PD-L1 inhibitors (IO) after 1st-line chemotherapy. The median age was 66 years (range, 29-89). 142 pts (65%) were male and 172 (78%) were smokers. Concomitant STK11 mutations were detected in 33 pts (15%) with no difference in the mutation frequency among KRAS mutation subtypes. KRAS G12C was significantly associated with high TMB (≥ 10 mut/Mb) (p = 0.03), and KRAS G12C or G12V with high PD-L1 expression (≥ 50%) (p = 0.02). In pts who received IO, median progression-free survival (mPFS) was significantly longer in pts with KRAS G12C or G12V than in those with other KRAS mutations (4.7 vs 2.0 months, hazard ratio (HR) 0.58 [95%CI 0.43-0.78], p < 0.01). Among pts with KRAS G12C or G12V, mPFS of IO was significantly shorter in pts with concomitant STK11 mutations than in those without (1.8 vs. 5.7 months, HR 1.97 [95%CI 1.06-3.41], p = 0.02). These correlations were not observed in platinum-containing chemotherapy (Plt-CTx). There were also no significant differences in IO and Plt-CTx efficacies between with and without other concomitant mutations, such as TP53, RB1, CDKN2A and PTEN mutations. Conclusions: Non-sq NSCLC pts with KRAS G12C/V were more sensitive to IO therapies than those with other KRAS mutations, but KRAS G12C/V-positive pts with concomitant STK11 mutations were less sensitive than those without. These results could be highly informative in the development of novel targeted therapies for KRAS-mutated NSCLC.

Abstract. Arid and semiarid ecosystems contain relatively high species diversity and are subject to intense use, in particular extensive cattle grazing, which has favored the expansion and encroachment of perennial thorny shrubs into the grasslands, thus decreasing the value of the rangeland. However, these environments have been shown to positively impact global carbon dynamics. Machine learning and remote sensing have enhanced our knowledge about carbon dynamics, but they need to be further developed and adapted to particular analysis. We measured the net ecosystem exchange (NEE) of C with the eddy covariance (EC) method and estimated gross primary production (GPP) in a thorny scrub at Bernal in Mexico. We tested the agreement between EC estimates and remotely sensed GPP estimates from the Moderate Resolution Imaging Spectroradiometer (MODIS), and also with two alternative modeling methods: ordinary-least-squares (OLS) regression and ensembles of machine learning algorithms (EMLs). The variables used as predictors were MODIS spectral bands, vegetation indices and products, and gridded environmental variables. The Bernal site was a carbon sink even though it was overgrazed, the average NEE during 15 months of 2017 and 2018 was −0.78 gCm-2d-1, and the flux was negative or neutral during the measured months. The probability of agreement (θs) represented the agreement between observed and estimated values of GPP across the range of measurement. According to the mean value of θs, agreement was higher for the EML (0.6) followed by OLS (0.5) and then MODIS (0.24). This graphic metric was more informative than r2 (0.98, 0.67, 0.58, respectively) to evaluate the model performance. This was particularly true for MODIS because the maximum θs of 4.3 was for measurements of 0.8 gCm-2d-1 and then decreased steadily below 1 θs for measurements above 6.5 gCm-2d-1 for this scrub vegetation. In the case of EML and OLS, the θs was stable across the range of measurement. We used an EML for the Ameriflux site US-SRM, which is similar in vegetation and climate, to predict GPP at Bernal, but θs was low (0.16), indicating the local specificity of this model. Although cacti were an important component of the vegetation, the nighttime flux was characterized by positive NEE, suggesting that the photosynthetic dark-cycle flux of cacti was lower than ecosystem respiration. The discrepancy between MODIS and EC GPP estimates stresses the need to understand the limitations of both methods.

Rats are known as vectors and reservoirs for various types of ecto and endoparasites. The existence of rats as cosmopolitan animals allows for complex parasitic transmission due to the relationship between humans, animals, and the environment. This study aimed to provide informative data on the types of rat along with their ecto- and endoparasites. This research is a qualitative descriptive study. Data collection was carried out by random sampling survey with a point time approach. Data collection was carried out in 4 villages, namely Tugurejo, Mangkang Wetan, Mangunharjo, and Mangkang Kulon Villages, Tugu District, Semarang City. A total of 89 rats were obtained, the species obtained were R. norvegicus, R. argentiventer, R. exulans, R. tiomanicus, R. surifer, R. tanezumi, B indica, and S. murinus. Ectoparasite infestation was found in all types of rats except S. murinus. The ectoparasites found were Xenopsylla cheopis and Laelaps echidninus which were reported as the main vectors of murine typhus, epidemic typhus, bartonellosis as well as scrub typhus and Q-fever disease. Endoparasite infestation was found in the intestinal organs, namely Diphyllobothrium sp. and two species of worm eggs Hymnoepis sp. and Trichuris trichiura which were reported as the cause of Diphyllobothriasis as well as digestion, absorption, which can result in the loss of protein, carbohydrates, fats, and blood in large quantities. Diphyllobothriasis is not transmitted from person to person, more than one family member can be infected by sharing common meals and having similar eating habits. This study can be used as an early warning for community against the potential of infectious diseases from rats as vectors in Tugu District, Semarang related to rats density, endoparasites and their ectoparasites.

The management of the remainder of Europe’s once extensive forests is hampered by a poor understanding of the character of the vegetation and drivers of change before the onset of clearance for farming. Pollen data indicate a closed-canopy, mixed-deciduous forest, contrasting with the assertion that large herbivores would have maintained a mosaic of open grassland, regenerating scrub and forested groves. Coprophilous fungal spores from sedimentary sequences are increasingly used as a proxy for past herbivore impact on vegetation, but the method faces methodological and taphonomical issues. Using pollen trap data from a long-running experiment in Chillingham Wild Cattle Park, UK, we investigate the first steps in the mechanisms connecting herbivore density to the incorporation of fungal spores in sediments and assess the effects of environmental variables on this relationship. Herbivore utilisation levels correlate with dung fungal spore abundance. Chillingham is densely populated by large herbivores, but dung fungal spore influx is low. Herbivores may thus be present on the landscape but go undetected. The absence of dung fungal spores is therefore less informative than their presence. Dung fungal spores likely enter the sediment record through a different pathway from wind-borne pollen and thus dung fungal abundance is better expressed as influx rates than as percentage of total pollen. Landscape openness, vegetation type and site wetness do not distort the impact of utilisation levels on dung fungal spore representation. However, dung fungal spore influx varies markedly between seasons and years. Spores travel, leading to a background level of spore deposition across the landscape, and at times a depletion of spores, especially under wet weather conditions. Animal behaviour, as well as husbandry practices, can lead to the accumulation of dung, and thus fungal spores, in specific locations on the landscape that do not directly reflect grazing pressure.

Abstract Background Thirty-six entomopathogenic fungi (EPF) were isolated from soil and insect cadaver samples, collected from different forest types, viz., wet evergreen, moist deciduous, dry deciduous and scrub type in South India. Partial sequences of two parsimony informative genes ITS and RPB1 were determined under a phylogenetic approach for assessing the genetic diversity. Results Twenty-seven RPB1 gene sequences and 34 sequences of ITS1, 5.8S and ITS2 regions belonging to 36 EPF were analysed for identification and characterization. Four species of Metarhizium viz., M. anisopliae, M. roberstii, M. majus and M. guizhouense were differentiated. The isolates could be grouped into four main clades of 1–5. Most of the fungi appeared to be closely related to M. anisopliae. Based on the colony characters, colour, conidial size and shape, 27 isolates were morphologically identified as M. anisopliae. Seven strains were apparently related to M. robertsii, three isolates were similar to M. majus and the remaining one was identified as M. guizhouense. Morphological studies in congruence with phylogenetic analysis resolved the species diversity. Bioassay studies showed that M. quizhouense, M. majus and M. robertsii were effective against the banana stem weevil Odoiporus longicollis. Conclusions This is the first attempt to study the diversity and occurrence of Metarhizium species in forests of South India. Wet evergreen forest of Aralam in South India was rich in EPF diversity particularly for three species namely, M. quizhouense, M. robertsii and M. anisopliae.

The work presented in this PhD thesis defines a new approach for the modeling and the conceptualization of enterprise business processes in the perspective of building intelligent assistance software tools to support these processes. The proposed approach defines an organizational ontology, named K-CRIO. Its description is based on the Ontology Web Language. To illustrate our work, an intelligent assistance system has been designed and implemented according to the result from the modeling and conceptualization of a specific business process with the K-CRIO Ontology. It is a web-based application that integrates and takes full advantage of multi-agent systems.The K-CRIO Ontology is an Ontology dedicated to the study of organizations and the analysis of business processes adopting an organizational point of view. Specifically, it is used to understand, analyze and reason about organizations and the processes they implement. The targeted organizations are those composed of entities involved throughout products' design and, to do so, following a defined business process. The range of this type of organizations is quite wide. We have thus limited our study to organizations that produce software as the final process goal, specifically IT enterprises delivering software products or services. In this context, the K-CRIO ontology could be used to model structure of the considered organizations and model human activities appearing in their business processes. This ontology could be used to support process assistance within the described organizations. More specifically, the ontology could provide means for reasoning, annotating resources, monitoring design processes, enabling searches and pro-actively proposing tips and proper content. In order to illustrate the usage of K-CRIO, we apply K-CRIO on two different processes: the Waterfall Model and the Scrum methodology. These examples are both classical software-development processes. Moreover, for Scrum, the famous agile software-development process widely used in software enterprises, we have designed and developed an intelligent assistance tool. This tool mainly helps Scrum Masters to make decision by monitoring Scrum project teams' activities within their various projects and collecting knowledge about these activities.

Depuis la création du Manifeste Agile en 2001, les méthodes agiles n'ont cessé de prendre de l'ampleur dans les entreprises. L'enthousiasme à l'égard de ces approches provient notamment des bénéfices identifiés. Ces méthodes incrémentales et adaptatives apportent plus de valeur, permettent une réduction des délais de développement informatique et sont à l'origine d'une amélioration de la qualité du produit délivré. Au-delà de la méthode de conception utilisée, afin que l'implantation d'une technologie présente des bénéfices pour les entreprises, il faut au préalable que les individus l'acceptent et l'utilisent. Menée en collaboration avec une compagnie aérienne française, cette thèse partenariale CIFRE porte sur la compréhension du processus d'acceptation des technologies lors de leur conception à l'aide de la méthode agile Scrum. La présente recherche a pour but d'identifier les dimensions et les facteurs favorisant ou freinant l'adoption de la technologie tout au long du processus de conception. Afin de répondre à cet objectif quatre études ont été menées selon une méthodologie basée sur une triangulation inter-méthodes dans un projet réel de conception. L'objectif de la première étude, à visée exploratoire, est d'apprécier la méthode agile Scrum en s'intéressant au travail des concepteurs. La seconde traite de l'acceptabilité sociale de la technologie : elle vise à identifier les perceptions des utilisateurs de la technologie. La troisième évalue l'acceptabilité pratique qui s'appuie sur la compatibilité entre l'utilisateur, ses tâches et la technologie. La quatrième s'intéresse à l'acceptation située qui vise à étudier l'adoption des technologies en contexte réel d'usage. Nos résultats confirment le lien existant entre le mode de conception de la technologie et son acceptation. Ils montrent le rôle des trois approches (sociale, pratique et située) dans l'adoption des technologies ainsi que l'influence de nombreux facteurs. Pour conclure, nous revenons sur les principales contributions théorique et méthodologique de cette thèse. Nous partageons nos réflexions sur les apports de l'ergonomie dans l'étude de l'adoption des technologies agiles. Nous présentons les implications pratiques de nos résultats dans la conception du dispositif technologique étudié et dans la conduite de projet agile. Enfin, nous discutons des contraintes de nos études et des perspectives de recherche qui en découlent
Since the agile manifesto creation in 2001, agile methods have steadily gained popularity in companies. One of the reasons for the enthusiasm towards these approaches is their identified benefits. These incremental and adaptive methods bring more value, allow a reduction in IT development times and improve the quality of the delivered product. However, beyond the design method used, in order for the implementation of a technology to be beneficial to businesses, it must first be accepted and used by individuals. Conducted in collaboration with a French airline company, this CIFRE partnership thesis focuses on understanding the process of technology acceptance during their design phase, using the Scrum agile method. The purpose of this research is to identify the dimensions and factors that promote or hinder technology adoption throughout the design process. In order to address this objective, four studies were conducted using a methodology based on cross-method triangulation in an actual design project. The objective of the first study, which is exploratory, is to assess the Scrum agile method by looking at the work of designers. The second focuses on the social acceptability of the technology: it aims at identifying the perceptions of the users of the technology. The third study considers practical acceptability, which is based on the compatibility between the user, their tasks and the technology itself. The fourth focuses on situated acceptance, which aims at studying the adoption of technologies in their real context of use. Our results confirm the link between the technology design mode and its acceptance. They show the role of the three approaches (social, practical and situated) in technology adoption as well as the influence of many other factors. As a conclusion, we review the main theoretical and methodological contributions of this thesis. We share our thoughts on the contributions of ergonomics in the study of the appropriation of agile technologies. We then present the practical implications of our results in the design of the technological device studied and in the implementation of agile projects. Finally, we discuss the constraints of our studies and the resulting research perspectives

Agile methodologies have become the standard approach to software development. The most popular and used one is Scrum. Scrum is a very simple and flexible framework that respond to unpredictability in a really effective way. However, his implementation must be correct, and since Scrum tells you what to do but not how to do it, this is not trivial. In this thesis I will describe the Scrum Framework, how to implement it and a tool that can help to do this. The thesis is divided into three parts. The first part is called Scrum. Here I will introduce the framework itself, its key concepts and its components. In Scrum there are three components: roles, meetings and artifacts. Each of these is meant to accomplish a series of specific tasks. After describing the “what to do”, in the second part, Best Practices, I will focus on the “how to do it”. For example, how to decide which items should be included in the next sprint, how to estimate tasks, and how should the team workspace be. Finally, in the third part called Tools, I will introduce Visual Studio Online, a cloud service from Microsoft that offers Git and TFVC repositories and the opportunity to manage projects with Scrum. == Versione italiana: I metodi Agile sono diventati l’approccio standard per lo sviluppo di software. Il più famoso ed utilizzato è Scrum. Scrum è un framework molto semplice e flessibile che risponde ai cambiamenti in una maniera molto efficace. La sua implementazione deve però essere corretta, e visto che Scrum ci dice cosa fare ma non come farlo, questo non risulta essere immediato. In questa tesi descriverò Scrum, come implementarlo ed uno strumento che ci può aiutare a farlo. La tesi è divisa in tre parti. La prima parte è chiamata Scrum. Qui introdurrò il framework, i suoi concetti base e le sue componenti. In Scrum ci sono tre componenti: i ruoli, i meeting e gli artifact. Ognuno di questi è studiato per svolgere una serie di compiti specifici. Dopo aver descritto il “cosa fare”, nella seconda parte, Best Practices, mi concentrerò sul “come farlo”. Ad esempio, come decidere quali oggetti includere nella prossima sprint, come stimare ogni task e come dovrebbe essere il luogo di lavoro del team. Infine, nella terza parte chiamata Tools, introdurrò Visual Studio Online, un servizio cloud della Microsoft che offre repository Git e TFVC e l’opportunità di gestire un progetto con Scrum.

In un'epoca in cui la società è costantemente connessa alla rete, è presto nata l'esigenza di accedere all'informazione in una maniera più immediata ed intuitiva. Questo ha portato alla nascita e allo sviluppo dell'Internet of Things e degli Embedded Systems. Al giorno d'oggi in particolare, sia nel contesto italiano che internazionale, è in grande crescita il numero di imprese del mondo ICT che investono risorse su una branca dell'IoT, che è quella del Wearable Computing, ovvero delle nuove tecnologie indossabili. Questa tesi si pone essenzialmente l'obiettivo di indagare quali siano i nuovi processi e le architetture che coinvolgono lo sviluppo dei sistemi Software moderni e orientati al contesto Wearable e Mobile, facendo un confronto con le esigenze del passato. A tale scopo si apporteranno vari esempi di esperienza diretta nell'ambito di un tirocinio aziendale. Si andranno poi a definire dettagliatamente le fasi di analisi, design ed implementazione che hanno portato alla costruzione di una Wearable Application usando le tecnologie fornite da Google per lo sviluppo su Android Wear.

Spectacular Snakes of Australia showcases these beautiful creatures which play such an important part in our biodiversity. It portrays most of the species found in Australia, such as tiger snakes, copperheads, brown snakes, death adders and sea snakes, up close and personal. It also includes some unique photographs, such as the hatching of scrub pythons, that offer a rare glimpse into their more intimate lives. The informative text, based on the latest research, describes the reproductive biology, behaviour, predators and prey of these reptiles, as well as their habitat and conservation values. Readers will explore the importance of colours and patterns in allowing snakes to blend into their environment, their defence and attack mechanisms, and the adaptations they have undergone to cope with their surroundings. In addition, the author provides some anecdotes on his encounters with snakes, and clears up a few myths regarding snake behaviour. Richly illustrated with exceptional photographs, Spectacular Snakes of Australia features the deadly serious as well as the quirky – from snakes that love water to those with potent venom, and even snakes that are blind! This book is a real treat for snake lovers.