Academic literature on the topic 'SDHE'
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Journal articles on the topic "SDHE"
1
Lee, Hansong, Seongdo Jeong, Yeuni Yu, et al. "Risk of metastatic pheochromocytoma and paraganglioma in SDHx mutation carriers: a systematic review and updated meta-analysis." Journal of Medical Genetics 57, no. 4 (2019): 217–25. http://dx.doi.org/10.1136/jmedgenet-2019-106324.
Full textAbstract:
BackgroundPheochromocytoma and paraganglioma (PPGL) are tumours that arise from chromaffin cells. Some genetic mutations influence PPGL, among which, those in genes encoding subunits of succinate dehydrogenase (SDHA, SDHB, SDHC and SDHD) and assembly factor (SDHAF2) are the most relevant. However, the risk of metastasis posed by these mutations is not reported except for SDHB and SDHD mutations. This study aimed to update the metastatic risks, considering prevalence and incidence of each SDHx mutation, which were dealt formerly all together.MethodsWe searched EMBASE and MEDLINE and selected 27 articles. The patients included in the studies were divided into three groups depending on the presence of PPGL. We checked the heterogeneity between studies and performed a meta-analysis using Hartung-Knapp-Sidik-Jonkman method based on a random effect model.ResultsThe highest PPGL prevalence was for SDHB mutation, ranging from 23% to 31%, and for SDHC mutation (23%), followed by that for SDHA mutation (16%). The lowest prevalence was for SDHD mutation, ranging from 6% to 8%. SDHAF2 mutation showed no metastatic events. The PPGL incidence showed a tendency similar to that of its prevalence with the highest risk of metastasis posed by SDHB mutation (12%–41%) and the lowest risk by SDHD mutation (~4%).ConclusionThere was no integrated evidence of how SDHx mutations are related to metastatic PPGL. However, these findings suggest that SDHA, SDHB and SDHC mutations are highly associated and should be tested as indicators of metastasis in patients with PPGL.
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Maher, Megan J., Anuradha S. Herath, Saumya R. Udagedara, David A. Dougan, and Kaye N. Truscott. "Crystal structure of bacterial succinate:quinone oxidoreductase flavoprotein SdhA in complex with its assembly factor SdhE." Proceedings of the National Academy of Sciences 115, no. 12 (2018): 2982–87. http://dx.doi.org/10.1073/pnas.1800195115.
Full textAbstract:
Succinate:quinone oxidoreductase (SQR) functions in energy metabolism, coupling the tricarboxylic acid cycle and electron transport chain in bacteria and mitochondria. The biogenesis of flavinylated SdhA, the catalytic subunit of SQR, is assisted by a highly conserved assembly factor termed SdhE in bacteria via an unknown mechanism. By using X-ray crystallography, we have solved the structure of Escherichia coli SdhE in complex with SdhA to 2.15-Å resolution. Our structure shows that SdhE makes a direct interaction with the flavin adenine dinucleotide-linked residue His45 in SdhA and maintains the capping domain of SdhA in an “open” conformation. This displaces the catalytic residues of the succinate dehydrogenase active site by as much as 9.0 Å compared with SdhA in the assembled SQR complex. These data suggest that bacterial SdhE proteins, and their mitochondrial homologs, are assembly chaperones that constrain the conformation of SdhA to facilitate efficient flavinylation while regulating succinate dehydrogenase activity for productive biogenesis of SQR.
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Guzy, Robert D., Bhumika Sharma, Eric Bell, Navdeep S. Chandel, and Paul T. Schumacker. "Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis." Molecular and Cellular Biology 28, no. 2 (2007): 718–31. http://dx.doi.org/10.1128/mcb.01338-07.
Full textAbstract:
ABSTRACT Mitochondrial complex II is a tumor suppressor comprised of four subunits (SdhA, SdhB, SdhC, and SdhD). Mutations in any of these should disrupt complex II enzymatic activity, yet defects in SdhA produce bioenergetic deficiency while defects in SdhB, SdhC, or SdhD induce tumor formation. The mechanisms underlying these differences are not known. We show that the inhibition of distal subunits of complex II, either pharmacologically or via RNA interference of SdhB, increases normoxic reactive oxygen species (ROS) production, increases hypoxia-inducible factor alpha (HIF-α) stabilization in an ROS-dependent manner, and increases growth rates in vitro and in vivo without affecting hypoxia-mediated activation of HIF-α. Proximal pharmacologic inhibition or RNA interference of complex II at SdhA, however, does not increase normoxic ROS production or HIF-α stabilization and results in decreased growth rates in vitro and in vivo. Furthermore, the enhanced growth rates resulting from SdhB suppression are inhibited by the suppression of HIF-1α and/or HIF-2α, indicating that the mechanism of SdhB-induced tumor formation relies upon ROS production and subsequent HIF-α activation. Therefore, differences in ROS production, HIF proliferation, and cell proliferation contribute to the differences in tumor phenotype in cells lacking SdhB as opposed to those lacking SdhA.
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Moog, Sophie, Charlotte Lussey-Lepoutre, and Judith Favier. "Epigenetic and metabolic reprogramming of SDH-deficient paragangliomas." Endocrine-Related Cancer 27, no. 12 (2020): R451—R463. http://dx.doi.org/10.1530/erc-20-0346.
Full textAbstract:
Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors arising from the adrenal medulla or extra-adrenal paraganglia. Around 40% of all cases are caused by a germline mutation in a susceptibility gene, half of which being found in an SDHx gene (SDHA, SDHB, SDHC, SDHD or SDHAF2). They encode the four subunits and assembly factor of succinate dehydrogenase (SDH), a mitochondrial enzyme involved both in the tricarboxylic acid cycle and electron transport chain. SDHx mutations lead to the accumulation of succinate, which acts as an oncometabolite by inhibiting iron(II) and alpha-ketoglutarate-dependent dioxygenases thereby regulating the cell’s hypoxic response and epigenetic processes. Moreover, SDHx mutations induce cell metabolic reprogramming and redox imbalance. Major discoveries in PPGL pathophysiology have been made since the initial discovery of SDHD gene mutations in 2000, improving the understanding of their biology and patient management. It indeed provides new opportunities for diagnostic tools and innovative therapeutic targets in order to improve the prognosis of patients affected by these rare tumors, in particular in the context of metastatic diseases associated with SDHB mutations. This review first describes an overview of the pathophysiology and then focuses on clinical implications of the epigenetic and metabolic reprogramming of SDH-deficient PPGL.
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Timmers, Henri J. L. M., Anne-Paule Gimenez-Roqueplo, Massimo Mannelli, and Karel Pacak. "Clinical aspects of SDHx-related pheochromocytoma and paraganglioma." Endocrine-Related Cancer 16, no. 2 (2009): 391–400. http://dx.doi.org/10.1677/erc-08-0284.
Full textAbstract:
Paragangliomas (PGLs) derive from either sympathetic chromaffin tissue in adrenal and extra-adrenal abdominal or thoracic locations, or from parasympathetic tissue of the head and neck. Mutations of nuclear genes encoding subunits B, C, and D of the mitochondrial enzyme succinate dehydrogenase (SDHB 1p35-p36.1, SDHC 1q21, SDHD 11q23) give rise to hereditary PGL syndromes PGL4, PGL3, and PGL1 respectively. The susceptibility gene for PGL2 on 11q13.1 remains unidentified. Mitochondrial dysfunction due to SDHx mutations have been linked to tumorigenesis by upregulation of hypoxic and angiogenesis pathways, apoptosis resistance and developmental culling of neuronal precursor cells. SDHB-, SDHC-, and SDHD-associated PGLs give rise to more or less distinct clinical phenotypes. SDHB mutations mainly predispose to extra-adrenal, and to a lesser extent, adrenal PGLs, with a high malignant potential, but also head and neck paragangliomas (HNPGL). SDHD mutations are typically associated with multifocal HNPGL and usually benign adrenal and extra-adrenal PGLs. SDHC mutations are a rare cause of mainly HNPGL. Most abdominal and thoracic SDHB-PGLs hypersecrete either norepinephrine or norepinephrine and dopamine. However, only some hypersecrete dopamine, are biochemically silent. The biochemical phenotype of SDHD-PGL has not been systematically studied. For the localization of PGL, several positron emission tomography (PET) tracers are available. Metastatic SDHB-PGL is the best localized by [18F]-fluorodeoxyglucose PET. The identification of SDHx mutations in patients with PGL is warranted for a tailor-made approach to the biochemical diagnosis, imaging, treatment, follow-up, and family screening.
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Kim, Se-Hyuk, Tae Hoon Roh, Hyunee Yim, et al. "GENE-05. THE LOSS OF SUCCINATE DEHYDROGENASE B EXPRESSION IS FREQUENTLY IDENTIFIED IN HEMANGIOBLASTOMA OF THE CENTRAL NERVOUS SYSTEM." Neuro-Oncology 21, Supplement_6 (2019): vi98. http://dx.doi.org/10.1093/neuonc/noz175.407.
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Abstract Succinate dehydrogenase (SDH) is a mitochondrial enzyme that plays an important role in both the Krebs cycle and the electron transport chain. SDH inactivation is associated with tumorigenesis in certain types of tumor. SDH consists of subunits A, B, C and D (SDHA, SDHB, SDHC, and SDHD, respectively). Immunohistochemistry for SDHB is a reliable method for detecting the inactivation of SDH by mutations in SDHA, SDHB, SDHC, SDHD and SDH complex assembly factor 2 (SDHAF2) genes with high sensitivity and specificity. SDHB immunohistochemistry has been used to examine the inactivation of SDH in various types of tumors. However, data on central nervous system (CNS) tumors are very limited. In the present study, we investigated the loss of SDHB immunoexpression in 90 cases of CNS tumors. Among the 90 cases of CNS tumors, only three cases of hemangioblastoma showed loss of SDHB immunoexpression. We further investigated SDHB immunoexpression in 35 cases of hemangioblastoma and found that 28 (80%) showed either negative or weak-diffuse pattern of SDHB immunoexpression, which suggests the inactivation of SDH. Our results suggest that SDH inactivation may represent an alternative pathway in the tumorigenesis of hemangioblastoma.
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Ilanchezhian, Maran, Sarah N. Fuller, Margarita Raygada, et al. "Clinical characterization of patients with SDHC epimutation in gastrointestinal stromal tumors." Journal of Clinical Oncology 37, no. 15_suppl (2019): 11033. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.11033.
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11033 Background: Gastrointestinal Stromal Tumors are the most common malignancy in the GI tract. While the vast majority exhibit somatic mutations in KIT and PDGFRA, approximately 15% of GIST patients do not have this feature. This group of KIT and PDGFRA “wildtype” GISTs have in common a negative expression of SDHB when interrogated by immunohistochemistry. Succinate dehydrogenase (SDH) is a conserved enzyme that plays a critical role in cellular metabolism and energy production. A loss in SDH function is a mechanism observed in several types of cancers, and germline SDH mutations are considered a tumor predisposition syndrome. This group has reported that SDH-deficient gastrointestinal stromal tumors often harbor germline mutations in the SDH subunit genes (SDHA, SDHB, SDHC, and SDHD, termed SDHx). There is, however, a defined group that shows lack of SDH expression in the absence of mutation. Methods: We performed targeted exome sequencing on GIST patients’ tumor samples from the NIH GIST clinic and identified 25 SDHx-WT cases. Genome-wide DNA methylation and expression profiling showed SDHC promoter-specific CpG island hypermethylation and gene silencing in these 25 SDHx-WT, SDH deficient GISTs. Results: Clinical characterization of this cohort revealed that 24 of 25 SDHC-epimutant GISTs occurred in female patients, with a median age of 12 upon diagnosis. The median tumor size of this cohort of patients was 4.0 cm. Of the 16 patients from whom we were able to obtain complete pathology data, 15 showed epithelioid or mixed-epithelioid tumor morphology. All of them showed negative immunohistochemical staining for SDHB. 15 of 16 patients had multifocal tumors, which is a common finding in this population. Conclusions: The profiling of this cohort provides further insights into the natural history and pathogenesis of SDHC-epimutant GIST tumors.
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Main, Ailsa Maria, Maria Rossing, Line Borgwardt, Birgitte Grønkær Toft, Åse Krogh Rasmussen, and Ulla Feldt-Rasmussen. "Genotype–phenotype associations in PPGLs in 59 patients with variants in SDHX genes." Endocrine Connections 9, no. 8 (2020): 793–803. http://dx.doi.org/10.1530/ec-20-0279.
Full textAbstract:
Phaeochromocytomas and paragangliomas (PPGLs) are tumours of the adrenal medulla and extra-adrenal sympathetic nervous system which often secrete catecholamines. Variants of the SDHX (SDHA, -AF2, -B, -C, -D) genes are a frequent cause of familial PPGLs. In this study from a single tertiary centre, we aimed to characterise the genotype–phenotype associations in patients diagnosed with germline variants in SDHX genes. We also assessed whether systematic screening of family members resulted in earlier detection of tumours. The study cohort comprised all individuals (n = 59) diagnosed with a rare variant in SDHX during a 13-year period. Patient- and pathology records were checked for clinical characteristics and histopathological findings. We found distinct differences in the clinical and histopathological characteristics between genetic variants in SDHB. We identified two SDHB variants with distinct phenotypical patterns. Family screening for SDHB variants resulted in earlier detection of tumours in two families. Patients with SDHA, SDHC and SDHD variants also had malignant phenotypes, underlining the necessity for a broad genetic screening of the proband. Our study corroborates previous findings of poor prognostic markers and found that the genetic variants and clinical phenotype are linked and, therefore, useful in the decision of clinical follow-up. Regular tumour screening of carriers of pathogenic variants may lead to an earlier diagnosis and expected better prognosis. The development of a combined algorithm with clinical, genetic, morphological, and biochemical factors may be the future for improved clinical risk stratification, forming a basis for larger multi-centre follow up studies.
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Daniel, Eleni, Robert Jones, Matthew Bull, and John Newell-Price. "Rapid-sequence MRI for long-term surveillance for paraganglioma and phaeochromocytoma in patients with succinate dehydrogenase mutations." European Journal of Endocrinology 175, no. 6 (2016): 561–70. http://dx.doi.org/10.1530/eje-16-0595.
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Background Patients with SDHx mutations need long-term radiological surveillance for the development of paragangliomas and phaeochromocytomas, but no longitudinal data exist. The aim of the study was to assess the performance of rapid-sequence non-contrast magnetic resonance imaging (MRI) in the long-term monitoring of patients with SDHx mutations. Methods Retrospective study between 2005 and 2015 at a University Hospital and regional endocrine genetics referral centre. Clinical and imaging data of 47 patients with SDHx mutations (SDHB (36), SDHC (6) and SDHD (5)) who had surveillance for detection of paragangliomas by rapid-sequence non-contrast MRI (base of skull to pubic symphysis) were collected. Results Twelve index cases (nine SDHB, one SDHC and two SDHD) and 35 mutation-positive relatives were monitored for a mean of 6.4 years (range 3.1–10.0 years). Mean age at the end of the study: SDHB 46.9 ± 17.6 years; SDHC 42.3 ± 24.4 years; SDHD 54.9 ± 10.6 years. On excluding imaging at initial diagnosis of index cases, 42 patients underwent 116 rapid-sequence MRI scans: 83 scans were negative and 31 scans were positive for sPGL/HNPGL in 13 patients. Most patients had multiple scans (n = number of patients (number of rapid-sequence MRI scans during screening)): n = 9 (2), n = 20 (3), n = 6 (4), n = 1 (6). Nine patients (three index) were diagnosed with new paragangliomas during surveillance and non-operated tumour size was monitored in nine patients. There were two false-positive scans (1.6%). Scans were repeated every 27 ± 9 months. Conclusions Biannual rapid-sequence non-contrast MRI is effective to monitor patients with SDHx mutations for detection of new tumours and monitoring of known tumours.
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Amar, Laurence, Karel Pacak, Olivier Steichen, et al. "International consensus on initial screening and follow-up of asymptomatic SDHx mutation carriers." Nature Reviews Endocrinology 17, no. 7 (2021): 435–44. http://dx.doi.org/10.1038/s41574-021-00492-3.
Full textAbstract:
AbstractApproximately 20% of patients diagnosed with a phaeochromocytoma or paraganglioma carry a germline mutation in one of the succinate dehydrogenase (SDHx) genes (SDHA, SDHB, SDHC and SDHD), which encode the four subunits of the SDH enzyme. When a pathogenic SDHx mutation is identified in an affected patient, genetic counselling is proposed for first-degree relatives. Optimal initial evaluation and follow-up of people who are asymptomatic but might carry SDHx mutations have not yet been agreed. Thus, we established an international consensus algorithm of clinical, biochemical and imaging screening at diagnosis and during surveillance for both adults and children. An international panel of 29 experts from 12 countries was assembled, and the Delphi method was used to reach a consensus on 41 statements. This Consensus Statement covers a range of topics, including age of first genetic testing, appropriate biochemical and imaging tests for initial tumour screening and follow-up, screening for rare SDHx-related tumours and management of elderly people who have an SDHx mutation. This Consensus Statement focuses on the management of asymptomatic SDHx mutation carriers and provides clinicians with much-needed guidance. The standardization of practice will enable prospective studies in the near future.
Dissertations / Theses on the topic "SDHE"
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Louw, Nadja. "Hereditary paraganglioma in South Africa : An investigation of the Succinate-ubiquinone Oxidoreductase subunit genes, SDHB, SDHC and SDHD." Diss., University of Pretoria, 2014. http://hdl.handle.net/2263/79271.
Full textAbstract:
Paraganglioma (PGL) are tumours occurring in the head-and-neck -, intra-abdominal
- and thoracic paraganglia. Germ-line mutations in genes encoding the subunits of
mitochondrial succinate dehydrogenase complex II (SDHB, SDHC, SDHD) and the
SDHAF2 gene are involved in hereditary paraganglioma. Our aim was to identify
mutations within these genes in ten South African PGL families. Individuals were
screened for mutations in SDHAF2 using Sanger sequencing and Multiplex Ligationdependent
Probe Amplification was utilised to investigate large rearrangements in
these genes. A 7905bp SDHB exon 3 deletion [c.201-4429_287-933del], was
identified in all SA families. The same deletion is reported as a founder mutation in
Dutch PGL families. Genotype analysis revealed a common haplotype at the SDHB
locus between SA and Dutch patients, indicating common ancestry. This is the first
Afrikaner SDHB founder mutation. These results now enable predictive testing of
other family members and allow better clinical management of the families.<br>Dissertation (MSc)--University of Pretoria, 2014.<br>Genetics<br>MSc<br>Unrestricted
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Moraes, Olívia Laquis de. "Descrição clínica, imunohistoquímica e estudo dos genes VHL, SDHB, SDHC, SDHD e MAX em uma série de pacientes com feocromocitoma e paraganglioma do Distrito Federal." reponame:Repositório Institucional da UnB, 2014. http://repositorio.unb.br/handle/10482/17088.
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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciência da Saúde, Programa de Pós-Graduação em Ciência da Saúde, 2014.<br>Submitted by Larissa Stefane Vieira Rodrigues (larissarodrigues@bce.unb.br) on 2014-11-18T15:37:56Z
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2014_OlíviaLaquisDeMoraes.pdf: 2089917 bytes, checksum: 3784e6f7d4b3f8c2057d7a208522f5b9 (MD5)<br>INTRODUÇÃO: Feocromocitomas (FEO) e paragangliomas (PGL) são tumores neuroendócrinos, originários de células chromafins, localizados na medula supra-renal e em tecidos extra-adrenais, respectivamente. FEO e PGL são geralmente benignos, com morbidade e mortalidade relacionadas com a produção de catecolaminas. Malignidade é relatada em aproximadamente 10%, dos casos. Estudos recentes têm mostrado que, pelo menos, 25% de todos os casos de FEO / PGL podem ter uma base genética. MÉTODOS: 17 pacientes com FEO / PGL foram incluídos. Os dados clínicos, bioquímicos e radiológicos foram obtidos dos prontuários médicos. Estudos histopatológicos e imuno-histoquímico para marcadores neuroendócrinos foram realizados. DNA genômico foi extraído e as regiões codificantes dos genes VHL, SDHB, SDHC SDHD, MAX foram amplificados e seqüenciados automaticamente. A técnica de MLPA foi utilizada para a triagem de grandes deleções / inserções. A análise do gene RET foi realizada em um paciente com evidência clínica de neoplasia endócrina múltipla do tipo 2A (MEN2A). O consentimento livre e esclarecido foi obtido de todos os pacientes. RESULTADOS: Este estudo é composto por 6 casos de PGL e 11 FEO, 5 pacientes tiveram história familiar postivia e 4 apresentaram malignidade. A análise Imunohistoquímica confirmou a origem de neuroendócrina de todos os tumores. A análise genética revelou a mutação (p.Q164R) no gene VHL em uma paciente do sexo feminino com FEO e hemangioblastoma cerebelar e sua filha assintomática. Uma mutação no gene RET foi encontrada (p.C618R), em uma paciente do sexo feminino com FEO e carcinoma medular da tiróide (CMT; NEM2A) e seus 2 filhas com CMT. Uma grande dleção do exon 1 do gene SDHB foi encontrada em quatro pacientes: Duas irmãs com PGL paraaortico, e dois casos aparentemente esporádicos apresentando PGL. DISCUSSÃO: O diagnóstico molecular feito pelo seqüenciamento de Sanger juntamente com o MLPA constitui uma estratégia adequada para procurar tanto mutações pontuais quanto grandes deleções. Associações genótipo-fenótipo para VHL e RET são bem descritos, mas os efeitos fisiopatológicos das grandes deleções no SDHB ainda não estão bem elucidados. Correlações fenotípicas ainda não foram bem caracterizados já que grandes deleções no SDHB tem uma apresentação muito variável. O SDHB pode atuar como um gene supressor tumoral, e uma grande deleção pode conduzir a um fenótipo tumoral. Estudos genéticos em pacientes com FEO e PGL são recomendados, uma vez que as mutações podem também ser encontrados em casos aparentemente esporádicos, e que um resultado positivo pode influenciar a monitorização clínica e o aconselhamento genético dos pacientes e seus descendentes. ___________________________________________________________________________ ABSTRACT<br>INTRODUCTION: Pheochromocytomas (PCC) and Paragangliomas (PGL) are neuroendocrine tumors originating from chromafin cells, located in the adrenal medulla and extra-adrenal tissue, respectively. PCC and PGL are usually benign, with morbidity and mortality related to the production of catecholamines. Malignancy is reported in approximately 10%; of cases. Recent studies have shown that at least 25%; of all PCC/PGL cases may have a genetic basis. METHODS: 17 patients with PCC/PGL were included. Clinical, biochemical and radiological data were obtained from medical records. Histopathological and immunohistochemical studies for neuroendocrine markers were performed. Genomic DNA was extracted and the coding regions of VHL, SDHB, SDHC SDHD, MAX were amplified and automatically sequenced. Multiplex ligand-probe amplification (MLPA) was used for screening large deletions/insertions. RET gene analysis was also performed in one patient with clinical evidence of multiple endocrine neoplasia type 2A (MEN2A). Genuine consent was obtained from all. RESULTS: Our series consisted of 6 PGLs and 11 PCCs patients; 5 had familial history and 4 were malignant. Immunohistochemistry confirmed the neuroendocrine origin of all tumors. Genetic analysis revealed the (p.Q164R) VHL mutation in a woman with PCC and cerebellar hemangioblastoma and her asymptomatic daughter. A RET mutation was found (p.C618R) in a woman with PCC and thyroid medullary carcinoma (TMCa; MEN2A) and her 2 daughters with TMCa. A large deletion of SDHB exon 1 was found in 4 patients: Two sisters with paraortic PGL, and two apparently sporadic cases presenting with PGL. DISCUSSION: Molecular diagnosis done by Sanger’s sequencing combined with MLPA constitute an adequate strategy to search for both point mutations and large deletions. Genotype-phenotype associations for VHL and RET are well described, but the pathophysiological effects of large deletions on SDHB are still unclear. No phenotype correlations have been characterized for large SDHB deletions due to a highly variable presentation. SDHB may act as a tumor suppressor, and a large deletion may lead to a tumor phenotype. Rational recommendations for genetic studies in PCCs and PGLs are in progress given that mutations may also be found in apparently sporadic cases, and that a positive result might influence clinical monitoring and genetic counseling of patients and their offspring.
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van, der Heide George, and n/a. "Effective strategies for conducting school development in health education programs." University of Canberra. Professional & Community Education, 1998. http://erl.canberra.edu.au./public/adt-AUC20060427.131945.
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Thesis Statement
The thesis argument is that theory can be developed about the
implementation, maintenance and dissemination of school health education
based on a school development approach. Such theory development can
assist teachers to design programs appropriate to the needs of their
classrooms, schools and communities.
Thesis Setting
The implementation and maintenance of school health education programs
has not usually been the focus of research and as a consequence is rarely
reported in the literature. The research in this thesis draws upon many
disciplines and fields but in order to answer the thesis questions
methodological processes were required that were consistent with current
school situations. The earlier School Development in Health Education
(SDHE) program's work in research, development and dissemination provided
the setting for the thesis.
Methodology of the Research
The methodology of the research study involved a case study approach using
both multiple and single case studies. Data have been drawn from SDHE
schools in South Australia undertaking health, sexuality and drug education.
The methodology adopted for the studies in this thesis is a case study design
incorporating an iterative theory-study-theory sequence in which an initial
theory statement derived from the literature guides the development of a
multiple case study which, in effect, 'tests' the theory in a qualitative way. The
finding of the case study then informs development and elaboration of the
theory statement in its second version. This is then used to test the next
multiple case study which leads to further development of the theory in its third
version. The third iteration of the theory is tested in a single case study that
leads to the fourth and final version of the theory.
Data analysis was aided by the use of the Q.S.R. NUD.IST computer package
that helped to manage and explore the thesis ideas about the data. In
establishing these syntheses the chain of evidence in the data sets was
maintained. The analysis also allowed the thesis findings to be used to test
theories about the data that answered the thesis questions.
Thesis Findings
The findings of the thesis are contained in the final version of the theory. The
theory is structured around program drivers, phases, types and processes that
together produce implementation, maintenance and dissemination. This final
theory statement is the basis for drawing the thesis conclusions.
Thesis Conclusions
It was concluded that patterns of factors that enhance and inhibit the
implementation, maintenance and dissemination of school health education
programs could be placed in a theoretical framework that can guide practice in
school health education.
To be successful school health education programs have to include three
critical elements: leadership, action research and funding. Leaders or program
drivers need to be identified and resourced; they may be principals or
designated teaching staff with access to decision making, policy processes
and resource allocation in schools. Teachers need to engage in a reflective
action research process to develop, modify and sustain their curriculum
development work. Programs require adequate funding resources for
teachers' professional development, including action research, and the
purchase of human and material resources. Schools planning to introduce
programs may learn from the experience of others but they must themselves
engage in the critical and essential program features identified in the final
version of the theory.
Implications
The thesis conclusions imply the need to use more efficient ways of bringing
schools' and teachers' hidden competence to the fore to support school health
education program through varied patterns of professional development,
technical support and curriculum development and implementation, and
through funding of enhanced professional practice for health literacy.
A major implication for the health sector is that many health workers need to
learn collaborative skills since there is a tendency to take control and attempt
to direct what teachers should do rather than work with and support them.
An implication for programs in complex social environments is the need for
careful planning in collaboration with other stakeholders. The critical elements
developed in this thesis also apply - leadership, action research and funding.
Evaluation can adopt a case study approach as a more suitable method for
examining what happens in programs than an overly simplistic approach of
assessing goals and objectives which ignores the differences in program
implementation for different sites with the necessary localisation.
Further Research
Further research suggested by the thesis findings are in the areas of school
health education in the changing administrative and management environment
today, and of the use of various types of case study research in tandem to
answer comprehensive and complex program performance questions.
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Loureiro, Vanessa Correia. "Rastreamento de mutações nos genes VHL, SDHB e SDHD em pacientes portadores de feocromocitoma ou também, paraganglioma esporádico." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-22042007-204736/.
Full textAbstract:
Os feocromocitomas são tumores neuroendócrinos constituídos de células cromafins secretoras de catecolaminas e neuropeptídeos diversos, cuja manifestação clínica mais comum é a hipertensão. Doze a 24% dos tumores aparentemente esporádicos, apresentam mutações germinativas em genes até então associados a síndromes herdadas, como, RET, VHL, SDHB e SDHD. A doença de von Hippel-Lindau é causada por mutações no gene VHL. As proteínas codificadas pelos genes SDHB e SDHD fazem parte do complexo mitocondrial II e da cadeia aeróbica de transporte de elétrons. O objetivo deste projeto de pesquisa foi o rastreamento de mutações nos genes VHL, SDHB e SDHD em pacientes portadores de feocromocitoma ou, também, paraganglioma esporádicos acompanhados no Serviço de Endocrinologia do Hospital das Clínicas da FMUSP. Todos os exons dos três genes estudados foram amplificados por PCR e analisados por dHPLC. Os amplicons que apresentaram cromatogramas suspeitos ao dHPLC foram submetidos ao seqüenciamento automático. Nenhuma mutação foi encontrada no gene VHL, apenas dois polimorfismos previamente descritos no exon 1, c. -77 C>T em dois pacientes e c - 195 G>A em 58,6% do total de alelos dos pacientes estudados. No gene SDHB foram encontrados dois polimorfismos previamente descritos (c. 201-36 G>T e c.487 T>C) em quatro pacientes, uma mutação silenciosa não descrita (c.540 G>A) e uma mutação previamente descrita em portadores de feocromocitoma (c. 293 G>A). Um mesmo paciente apresentou a mutação silenciosa c.540 G>A e o polimorfismo c.201-36 G>T. No gene SDHD foram encontrados dois polimorfismos descritos (c.204 C>T e c.315-32 T>C) em um paciente cada, uma variante alélica descrita na literatura na região 3\' não codificante cuja freqüência nunca foi estudada em outras populações (c.*612 C>T) e duas substituições nunca descritas na região 3\' não codificante (c.*799 T>C e c.*803 A>G). As variantes c.*612 C>T e c.*799 T>C foram detectadas em apenas um paciente cada e não foram encontradas em 200 alelos de controles normais estudados. A variante c.*803 A>G foi encontrada em nove de 76 alelos dos 38 pacientes (11,8%) e em cinco de 200 alelos de 100 controles não afetados (2,5%), sendo, portanto, um polimorfismo significativamente mais freqüente entre os portadores de feocromocitoma ou paraganglioma. Dentre os sete pacientes portadores do polimorfismo c.*803 A>G, três pacientes heterozigotos para este polimorfismo apresentaram um segundo polimorfismo no gene SDHD, sendo que um desses pacientes também apresentava uma mutação no gene SDHB. Dentre os demais quatro pacientes, dois apresentavam o polimorfismo c.*803 A>G em homozigose. Este polimorfismo ocorre no nucleotídeo localizado na posição -1 imediatamente 5\' ao Sítio de Clivagem do pré-mRNA para que ocorra a inserção da cauda Poli(A), fundamental para a estabilidade do mRNA. A substituição da base A pela base G muito provavelmente apresenta uma repercussão funcional, pois a base A na posição -1 é considerada como a mais eficiente na promoção da clivagem do pré-mRNA, enquanto a base G é considerada a menos eficiente (ordem de eficiência de clivagem A > U > C > G). Desta forma, a possibilidade desse polimorfismo conferir susceptibilidade ao desenvolvimento do feocromocitoma e do paraganglioma não está descartada, sendo provável que outros eventos genéticos sejam necessários para promover a tumorigênese. Em conclusão, esse estudo evidenciou uma baixa freqüência de mutações nas regiões codificantes dos genes VHL (mutações não detectadas), SDHB (5,2%) e SDHD (mutações não detectadas) nessa série de pacientes com feocromocitomas e paragangliomas esporádicos, porém, encontrou um polimorfismo na região 3\' não codificante do gene SDHD significativamente mais freqüente nos portadores desses tumores que em indivíduos controles não afetados, e que, por suas características, pode estar relacionado à etiopatogenia do feocromocitoma e do paraganglioma.<br>Pheochromocytomas are neuroendocrine tumors composed of chromaffin cells that produce and secrete catecholamines as well as a variety of neuropeptides, whose most common clinical manifestation is arterial hypertension. Twelve to 24% of the apparently sporadic pheochromocytomas, present germline mutations in genes previously associated to inherited familiar syndromes, such as, RET, VHL, SDHB e SDHD. The von Hippel-Lindau (VHL) disease occurs upon the VHL gene mutation - a tumor suppressor gene whose product encodes complexes with other proteins leading proteic substracts to the proteolysis. The proteins encoded by the SDHD and SDHB genes are parts of the complex mitochondrial II, as well as the aerobic chain of the electron transport. The aim of the present study was the screening of mutations in the VHL, SDHB and SDHD genes in patients harboring sporadic pheochromocytoma and/or paraganglioma, followed by the Endocrinology Service of Hospital das Clínicas of the University of São Paulo School of Medicine. All the three studied gene exons were amplified by polymerase chain reaction (PCR) and were analyzed by dHPLC, which was the method used for screen mutations. The samples with altered eluting progress were directly sequenced. No mutations were found in the VHL gene, only two polymorphisms previously described in the exon 1, c. -77 C>T in two patients and c - 195 G> in 58.6% out of the total alleles of the studied patients. Two polymorphisms previously described (c. 201-36 G>T and c.487 T>C) in the SDHB gene were found in four patients, as well as silent mutation not yet described (c.540 G>A) and a mutation previously described in patients with pheochromocytoma (c. 293 G>A). A particular patient presented the silent mutation c.540 G>A and the polymorphism c.201-36 G>T. In the SDHD gene two polymorpfisms previously described (c.204 C>T and c.315-32 T>C) were found, one in each patient, as well as an allelic variant previously described in the 3\' non-coding region whose frequency has never been studied in other populations (c.*612 C>T) and two substitutions never described in the 3\' non-coding region (c.*799 T>C and c.*803 A>G). The variants c.*612 C>T and c.*799 T>C were detected in only one patient each and have not been found in 200 alleles of normal control subjects studied. The variant c.*803 A>G was found in nine out of 76 alleles from 38 patients (11.8%) and in five out of 200 alleles from 100 non-affected subjects (2.5%), being, then, a polymorphism significantly more frequent among patients with pheochromocytoma or paraganglioma. Among those seven patients with the polymorphism c.*803 A>G, three patients heterozygotous for the polymorphism presented a second polymorphism in the SDHD gene and one of those patients also presented a mutation in the SDHB gene. Out of the other four patients, two presented the polymorphism c.*803 A>G in heterozygosis. This polymorphism occurs in the nucleotide localized in the position -1 immediately 5\' to the site where the pre-mRNA is cleaved for the insertion of the poly(A) tail, which is essencial to the mRNA stability. The substitution of the A to the G probably presents a functional repercussion, because the A in the position -1 is considered as the most efficient nucleotide in the pre-mRNA cleavage promotion, while the G is considered the least efficient one (scale of cleavage efficiency A > U > C > G). Therefore, the possibility of this polymorphism be associated with susceptibility to the development of pheochromocytoma and paraganglioma is not discarded, being possible that other genetic events are necessary to promote tumorigenesis. In conclusion, this study evidenced a low frequency of mutations in the coding regions of the genes VHL (mutations not detected), SDHB (5,2%) and SDHD (mutations not detected) in this series of patients with sporadic pheochromocytomas and paragangliomas, however, a polymorphism significantly more frequent in patients harboring those tumors was found in the 3\' non-coding region of the SDHD gene and, for its specific characteristics, it can very well be related to the etiopathogenesis of the pheochromocytoma and paraganglioma
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Kratky, Joseph J. "SERIES EXPANSION FOR SEMI-SPDES WITH REMARKS ON HYPERBOLIC SPDES ON THE LATTICE." Kent State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1310614464.
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Soderberg, Brock A. "Architecture while listening to SDRE." PDF viewer required Home page for entire collection, 2008. http://archives.udmercy.edu:8080/dspace/handle/10429/9.
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Calvet, Jean-Thierry. "Synchronisation des réseaux optiques SDH." Paris 6, 2003. http://www.theses.fr/2003PA066039.
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Leščiauskas, Vytautas. "SDH tinklo resursų įvertinimas ir optimizavimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2004. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2004~D_20040531_205209-50945.
Full textAbstract:
The software currently used by SDH net operators does not guarantee the automatic generation of routes between the selected nodes. This is the reason why the operators spend a lot of time on designing the nets manually. Despite all the time spent on designing, errors are still made which are the causes of net overload and connection disorders.
It is necessary to convert the measuring units of SDH resources from a tree type structure to real numbers, because the structure of the analyzed object’s resource units is hierarchical. After evaluation of these units the solution of this problem can be found in theory of graphs.
It is natural that given these data structures a special method is needed which would allow determining these structures and finding specific weight unit of edges of the graphs with which the problem is solved. The complexity of graph route composition algorithms is not satisfactory because the scope of real systems will be big enough. The amount of net nodes can exceed 500 and the amount of lines connecting them can be more than 5000.
It is not very difficult to implement the automatic generation of routes in principle. The knowledge of graph theory can be used to do that. But in solving real problems with the best known methods of graph theory the time of solution is not acceptable because of the big scope of the problem. It is possible to reduce the time of solution by increasing the efficiency of the system that solves the problem. The need for more... [to full text]
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Linkevičius, Edvardas. "SDH telekomunikacijų tinklo resursų skaičiavimo sistema." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2007. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2007~D_20070116_234500-14286.
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The Project “Resources evaluation system of SDH telecommunication network” is used for investigation of the efficiency of utilization of the existing TEO LT, AB SDH Trunk Network resources.
The essential problem is the lack of precise information on the free and used resources of the Network, their distribution and usage in the optimum and efficient manner. It was rather hard to establish the free and used SDH network resources and evaluate the efficiency of the Network. This brings essential influence and difficulties into the planning of network and investments since it is rather hard to take the economically viable decisions regarding the usage of the existing resources.
The SDH network resources evaluation system can be used for planning of trunk network resources and quick creation of flows’ transmission routes in a very efficient manner. The System gives the possibility to verify the new routes creation possibilities from any point of the network and execute the customers’ orders in a quick manner.
The System is developed as software with a direct interface with the TEO LT Network Information System SQL Base, and is going to use the data, stored in the SQL Base.
The Content of this project consists from:
• Analytical part of investigation
• Specification of requirements for designed system
• Common system requirements
• Data structure
• Network Resources Information Module
• Testing and User Guide
According content above the System “Resources evaluation system of SDH... [to full text]
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Gonçalves, Maria Aline. "Controle SDRE aplicado em suspensão veicular com amortecedor magneto-reológico." Universidade Tecnológica Federal do Paraná, 2017. http://repositorio.utfpr.edu.br/jspui/handle/1/2533.
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Desde que se inventou o automóvel, a suspensão veicular é objeto de pesquisa e estudo. A função do sistema de suspensão de um veículo é minimizar a aceleração vertical, isolando os passageiros de choques e vibrações promovendo conforto, reduzindo a fadiga o que beneficia a saúde e segurança dos motoristas. Este trabalho apresenta uma proposta para o controle da suspensão veicular utilizando um controlador SDRE aplicado ao amortecedor magneto-reológico. A eficiência do controle proposto pode ser evidenciada através de simulações computacionais utilizando um modelo matemático não linear de um quarto de carro e um modelo matemático não-lienar de meio de carro. A análise do desempenho do controle é realizada considerando excitações provocadas por irregularidades da estrada representadas por entradas do tipo degrau e senoidal. As simulações computacionais foram realizadas utilizando o programa Matlab®. Os resultados das simulações evidenciam que o controle proposto melhora dirigibilidade do veículo ao reduzir o deslocamento vertical do conjunto eixo-roda e contribui com o conforto dos passageiros reduzindo as oscilações na carroceria. Adicionalmente, foram realizadas análises de simulações de variações paramétricas afim de se verificar o comportamento do controle proposto diante de incertezas. Os estudos paramétricos demonstram que o controle permanece estável, mesmo quando submetido a variações paramétricas.<br>Since car was developed, vehicular suspension is an object of research and study. The function of the suspension system of a vehicle is to minimize vertical acceleration, isolating passengers from shocks and vibrations promoting comfort, reducing fatigue which benefits the health and safety of drivers. This work presents a proposal for the control of vehicle suspension using an SDRE controller applied to the magneto-rheological damper. The efficiency of the proposed control can be evidenced through computational simulations using a quarter-car nonlinear mathematical model and a half-car nonlinear mathematical model. The analysis of the controller's performance is performed considering the excitations caused by irregularities of the road represented by step input and sinusoidal. Computational simulations were performed using Matlab®. The simulation results show that the proposed control improves the vehicle's dirigibility by reducing the vertical displacement of the wheel and also contributes to the passengers' comfort by reducing oscillations in the vehicle's body. In addition, simulations of parametric variations were performed in order to verify the behavior of the proposed control in face of uncertainties. Parametric studies demonstrate that control remains stable, even when subjected to parametric variations.
Books on the topic "SDHE"
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dge legs phun tshogs/ rab brtan dge legs phun tshogs. sde dge'i mdun bro. Mi rigs dpe skrun khang, 2014.
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Dge-legs-phun-tshogs. Sde-dgeʼi mdun bro. [Si-khron Bod-yig Dpe-rñiṅ Bsdu-sgrig Khaṅ], 2014.
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Padma Sambhava, ca. 717-ca. 762. 23., ред. Bkaʼ thaṅ sde lṅa. Mi rigs dpe skrun khaṅ, 1986.
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Dge-legs-phun-tshogs. Sde-dgeʼi bro chen. [Si-khron Bod-yig Dpe-rñiṅ Bsdu-sgrig Khaṅ], 2014.
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van Helvoort, Huub. Next Generation SDH/SONET. John Wiley & Sons, Ltd, 2005. http://dx.doi.org/10.1002/0470091223.
Full textBook chapters on the topic "SDHE"
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Kapur, P. K., H. Pham, A. Gupta, and P. C. Jha. "SRGM Using SDE." In Springer Series in Reliability Engineering. Springer London, 2011. http://dx.doi.org/10.1007/978-0-85729-204-9_8.
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Mesiya, M. Farooque. "SONET and SDH Networks." In Handbook of Computer Networks. John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118256053.ch58.
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Iacus, Stefano M. "Numerical Methods for SDE." In Springer Series in Statistics. Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-75839-8_2.
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Schmid, Gary Bruno. "SDE-5: Der Selbstheilungsmythos." In Selbstheilung stärken. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-57674-8_6.
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Schmid, Gary Bruno. "Variationen zur SDE-Methode." In Selbstheilung stärken. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-57674-8_10.
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Hassler, Uwe. "Stochastic Differential Equations (SDE)." In Stochastic Processes and Calculus. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-23428-1_12.
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Allmendinger, Georg. "Sychrone-Digitale-Hierarchien (SDH)." In Aufgaben und Lösungen zur Elektronik und Kommunikationstechnik. Vieweg+Teubner, 2010. http://dx.doi.org/10.1007/978-3-8348-9731-2_33.
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Pittner, John, and Marwan A. Simaan. "Advanced Control: The Augmented SDRE Technique." In Advances in Industrial Control. Springer London, 2010. http://dx.doi.org/10.1007/978-0-85729-067-0_5.
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Karandikar, Rajeeva L., and B. V. Rao. "SDE Driven by r.c.l.l. Semimartingales." In Indian Statistical Institute Series. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8318-1_12.
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Schmid, Gary Bruno. "Die SDE-Methode im Überblick." In Selbstheilung stärken. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-57674-8_9.
Full textConference papers on the topic "SDHE"
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He, Li, Qi Meng, Wei Chen, Zhi-Ming Ma, and Tie-Yan Liu. "Differential Equations for Modeling Asynchronous Algorithms." In Twenty-Seventh International Joint Conference on Artificial Intelligence {IJCAI-18}. International Joint Conferences on Artificial Intelligence Organization, 2018. http://dx.doi.org/10.24963/ijcai.2018/307.
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Asynchronous stochastic gradient descent (ASGD) is a popular parallel optimization algorithm in machine learning. Most theoretical analysis on ASGD take a discrete view and prove upper bounds for their convergence rates. However, the discrete view has its intrinsic limitations: there is no characterizationof the optimization path and the proof techniques are induction-based and thus usually complicated. Inspired by the recent successful adoptions of stochastic differential equations (SDE) to the theoretical analysis of SGD, in this paper, we study the continuous approximation of ASGD by using stochastic differential delay equations (SDDE). We introduce the approximation method and study the approximation error. Then we conduct theoretical analysis on the convergence rate of ASGD algorithm based on the continuous approximation.There are two methods: moment estimation and energy function minimization can be used to analyzethe convergence rates. Moment estimation depends on the specific form of the loss function, while energy function minimization only leverages the convex property of the loss function, and does not depend on its specific form. In addition to the convergence analysis, the continuous view also helps us derive better convergence rates. All of this clearly shows the advantage of taking the continuous view in gradient descent algorithms.
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Boikos, Sosipatros A., Paraskevi Xekouki, Fabio R. Faucz, et al. "Abstract 568: Few Carney's Triad patients have mutations in two subunits of the succinate dehydrogenase enzyme (SDHB, SDHC)." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-568.
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Gao, Jianbo, Jing Hu, and Wen-wen Tung. "Multiscale Analysis of Biological Signals." In ASME 2011 Dynamic Systems and Control Conference and Bath/ASME Symposium on Fluid Power and Motion Control. ASMEDC, 2011. http://dx.doi.org/10.1115/dscc2011-6084.
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Complex systems often generate highly nonstationary and multiscale signals, due to nonlinear and stochastic interactions among their component systems and hierarchical regulations imposed by the operating environments. The further advances in the fields of life sciences, systems biology, nano-sciences, information systems, and physical sciences, have made it increasingly important to develop complexity measures that incorporate the concept of scale explicitly, so that different behaviors of the signals on varying scales can be simultaneously characterized by the same scale-dependent measure. Here, we propose such a measure, the scale-dependent Lyapunov exponent (SDLE), and develop a unified theory of multiscale analysis of complex data. We show that the SDLE can readily characterize low-dimensional chaos and random 1/fα processes, as well as accurately detect epileptic seizures from EEG data and distinguish healthy subjects from patients with congestive heart failure from heart rate variability (HRV) data. More importantly, our analyses of EEG and HRV data illustrate that commonly used complexity measures from information theory, chaos theory, and random fractal theory can be related to the values of the SDLE at specific scales, and useful information on the structured components of the data is also embodied by the SDLE.
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Zhong, Jing-hui, and Jun Zhang. "SDE." In the fourteenth international conference. ACM Press, 2012. http://dx.doi.org/10.1145/2330163.2330298.
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M. Barradas, Henrique, Ricardo F. Buzo, and Fábio B. Leão. "Novo método para estimação da corrente de curto-circuito em sistemas de distribuição de energia elétrica considerando a inserção de geração distribuída." In Simpósio Brasileiro de Sistemas Elétricos - SBSE2020. sbabra, 2020. http://dx.doi.org/10.48011/sbse.v1i1.2483.
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Este artigo apresenta um novo método para calcular o impacto na corrente de curto-circuito nas linhas de sistemas de distribuição de energia elétrica (SDEE) radiais considerando a inserção de Geração Distribuída (GD). O método foi desenvolvido a partir da aplicação de conceitos clássicos de circuitos elétricos, resultando em equações que permitem calcular o quanto a corrente de curto-circuito no SDEE é impactada com a inserção de GD. Para validação dos resultados do modelo proposto é utilizado um sistema de 5 barras, o qual é modelado no software DIgSILENT®. Os resultados do DIgSILENT® são comparados com os resultados obtidos através das equações propostas apresentando erro máximo absoluto de 0,67 A o que demonstra a eficiência e robustez do método proposto.
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Tyan, Feng, and Jeng Fu Shen. "SDRE missile guidance law." In 2010 8th IEEE International Conference on Control and Automation (ICCA). IEEE, 2010. http://dx.doi.org/10.1109/icca.2010.5524364.
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Mukherjee, Arpan, Rahul Rai, Puneet Singla, Tarunraj Singh, and Abani Patra. "An Adaptive Gaussian Mixture Model Approach Based Framework for Solving Fokker-Planck Kolmogorov Equation Related to High Dimensional Dynamical Systems." In ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/detc2016-60312.
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Engineering systems are often modeled as a large dimensional random process with additive noise. The analysis of such system involves a solution to simultaneous system of Stochastic Differential Equations (SDE). The exact solution to the SDE is given by the evolution of the probability density function (pdf) of the state vector through the application of Stochastic Calculus. The Fokker-Planck-Kolmogorov Equation (FPKE) provides approximate solution to the SDE by giving the time evolution equation for the non-Gaussian pdf of the state vector. In this paper, we outline a computational framework that combines linearization, clustering technique and the Adaptive Gaussian Mixture Model (AGMM) methodology for solving the Fokker-Planck-Kolmogorov Equation (FPKE) related to a high dimensional system. The linearization and clustering technique facilitate easier decomposition of the overall high dimensional FPKE system into a finite number of much lower dimension FPKE systems. The decomposition enables the solution method to be faster. Numerical simulations test the efficacy of our developed framework.
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S. de Morais, Guilherme, Mariana Resener, Maicon J. S. Ramos, and Younes Mohammadi. "Estabilidade transitória de sistemas de distribuição ativos com recursos energéticos distribuídos: um estudo de caso." In Congresso Brasileiro de Automática - 2020. sbabra, 2020. http://dx.doi.org/10.48011/asba.v2i1.1362.
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Estudos de estabilidade transitória em sistemas de distribuição de energia elétrica (SDEE) tem ganho importante atenção na literatura em decorrência da presença de recursos energéticos distribuídos (DERs). Entender os impactos no comportamento dinâmico de SDEE, causados pela integração de DERs, é fundamental para garantir a operação dentro de critérios estabelecidos pelo órgão regulador. Este trabalho estuda a estabilidade transitória do modelo modificado do sistema de distribuição desbalanceado IEEE 34-nós, na presença de DERs e diante de distúrbios causados na rede. O modelo contém um gerador síncrono (GS) e quatro sistemas de geração solar fotovoltaica (PV). As simulações, utilizando o software DIgSILENT PowerFactory, avaliaram o comportamento do sistema considerando distintos cenários como ilhamento e faltas na rede, diferentes níveis de carga e condições de geração, a partir das respostas de frequência, tensão, potência ativa e reativa e posição angular do rotor do GS. Para os testes analisados, não foram constatadas mudanças significativas na resposta dinâmica do sistema quando o nível de penetração das PVs foi modificada.
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Chavarette, Fa´bio Roberto, Jose´ Manoel Balthazar, Ce´lia Aparecida dos Reis, and Nelson Jose´ Peruzzi. "State Dependent Riccati Equation (SDRE) Control Method Applied in Cancellation of a Parametric Resonance in a Magnetically Levitated Body." In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-47406.
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Here, a simplified dynamical model of a magnetically levitated body is considered. The origin of an inertial Cartesian reference frame is set at the pivot point of the pendulum on the levitated body in its static equilibrium state (ie, the gap between the magnet on the base and the magnet on the body, in this state). The governing equations of motion has been derived and the characteristic feature of the strategy is the exploitation of the nonlinear effect of the inertial force associated, with the motion of a pendulum-type vibration absorber driven, by an appropriate control torque [4]. In the present paper, we analyzed the nonlinear dynamics of problem, discussed the energy transfer between the main system and the pendulum in time, and developed State Dependent Riccati Equation (SDRE) control design to reducing the unstable oscillatory movement of the magnetically levitated body to a stable fixed point. The simulations results showed the effectiveness of the (SDRE) control design.
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Khor, K. A., and P. Cheang. "Fracture Behavior and Tensile Adhesive Properties of HA Coatings." In ITSC 1997, edited by C. C. Berndt. ASM International, 1997. http://dx.doi.org/10.31399/asm.cp.itsc1997p0769.
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Abstract The attractive bioactive properties of HA are significantly reduced upon plasma spraying because of the phase transformation that accompanied the deposition process. One major factor that influence the extent to which the transformation occur appears to be the morphology and physical states of the HA raw powders. This paper reports the study on the influence of powder morphology and property on the fracture behaviour and tensile adhesive strength of plasma sprayed HA coatings. Three types of powders were used in the study; calcined HA (CHA), spray dried HA (SDHA) and flame spheroidised HA (SHA). The particle size range of 53 - 75 μm was employed for all 3 types of powders to effect an accurate comparison of the powders. Results show that the cohesive bond strength of the SHA coating was the highest because of the denser microstructure created by well-formed lamella splats. A correspondingly lower bond strength was recorded with less coherent coatings generated by agglomerated CHA and SDHA powders.
Reports on the topic "SDHE"
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Haddad, Ranwa. Revised and Augmented SDCE Model. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada354764.
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Haddad, Ranwa. Guidelines for the Use of SDCE. Defense Technical Information Center, 1998. http://dx.doi.org/10.21236/ada354765.
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George, Colin B. SDOE 650: System Architecture and Design. Office of Scientific and Technical Information (OSTI), 2014. http://dx.doi.org/10.2172/1171441.
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Malis, A., and W. Simpson. PPP over SONET/SDH. RFC Editor, 1999. http://dx.doi.org/10.17487/rfc2615.
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Banks, H. T., Hee-Dae Kwon, J. A. Toivanen, and H. T. Tran. An SDRE Based Estimator Approach for HIV Feedback Control. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada441233.
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Colon-Mercado, H., and D. David Hobbs. BASELINE MEMBRANE SELECTION AND CHARACTERIZATION FOR AN SDE. Office of Scientific and Technical Information (OSTI), 2007. http://dx.doi.org/10.2172/907767.
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Murakami, K., and M. Maruyama. MAPOS - Multiple Access Protocol over SONET/SDH Version 1. RFC Editor, 1997. http://dx.doi.org/10.17487/rfc2171.
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Putz, Sabine, and Bärbel Epp. Solar Heat for Cities: The Sustainable Solution for District Heating. Edited by Bärbel Epp. IEA SHC Task 55, 2019. http://dx.doi.org/10.18777/ieashc-task55-2019-0007.
Full textAbstract:
The brochure contains very useful info charts and general information about large scale SDH as well as several case studies of SDH installations in Denmark, China, Serbia, Austria, France, Latvia and Germany.
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Putz, Sabine, and Bärbel Epp. Solar Heat for Cities: The Sustainable Solution for District Heating - Turkish. Edited by Bärbel Epp. IEA SHC Task 55, 2021. http://dx.doi.org/10.18777/ieashc-task55-2021-0004.
Full textAbstract:
The brochure contains very useful info charts and general information about large scale SDH as well as several case studies of SDH installations in Denmark, China, Serbia, Austria, France, Latvia and Germany, translated into Turkish.