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1

Seidenberg, Jürgen, Geeske Stelljes, Lars Lange, Katharina Blumchen, and Ernst Rietschel. "Airlines provide too little information for allergy sufferers!" Allergo Journal International 29, no. 8 (2020): 262–79. http://dx.doi.org/10.1007/s40629-020-00147-1.

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Summary Introduction Allergic reactions are reported to account for approximately 2–4% of all medical emergencies on commercial airline flights. In 2016, the International Air Transport Association (IATA) published recommendations on risk prevention in severe allergies. Methods Using a written questionnaire and an internet search, an investigation was conducted on the extent to which airlines operating in Germany have implemented the IATA recommendations and, e.g., offer peanut/nut allergy sufferers appropriate measures. Results Only 14 of the 104 airlines contacted responded to the written su
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2

Jin, Hong Ying. "Design of Intelligent Search Engine with Multiple Agents." Applied Mechanics and Materials 496-500 (January 2014): 1937–40. http://dx.doi.org/10.4028/www.scientific.net/amm.496-500.1937.

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Because traditional search engine has lots of defect such as return too much information or search result has little use, it is necessary to study on intelligent search engine. Base on the analysis of general search engine defects, this paper presents an intelligent search engine with multiple agent. Then, the structure and search process was discussed in detail. At last, the superiority of the new scheme was analyzed compared with the general search engine.
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Cohen, Gene D. "An International Search for Innovation: A Challenge and a Call for Action." International Psychogeriatrics 6, no. 1 (1994): 3–4. http://dx.doi.org/10.1017/s1041610294001559.

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Samuel Johnson, at age 76, wrote about “this world where much is to be done and little to be known.” Two hundred years later, in the world of psychogeriatrics, too little is known about what is done. This becomes quite apparent at scientific meetings—especially international ones—where information is exchanged about new research and evolving ideas. Unfortunately, while research findings are more likely to find their way to dissemination via publication in a professional journal, innovative service and service delivery developments are less likely to be readily or adequately disseminated via th
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4

Haigh, Susan. "Library Catalogue Users Are Influenced by Trends in Web Searching." Evidence Based Library and Information Practice 1, no. 3 (2006): 77. http://dx.doi.org/10.18438/b8ks33.

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A review of:
 
 Novotny, Eric. “I Don’t Think I Click: A Protocol Analysis Study of Use of a Library Online Catalog in the Internet Age.” College & Research Libraries, 65.6 (Nov. 2004): 525-37.
 
 Objective – To explore how Web-savvy users think about and search an online catalogue. 
 
 Design – Protocol analysis study.
 
 Setting – Academic library (Pennsylvania State University Libraries).
 
 Subjects – Eighteen users (17 students, 1 faculty member) of an online public access catalog, divided into two groups of nine first-time and nine ex
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5

Rabkin, Rhoda. "The Aylwin Government and 'Tutelary' Democracy: A Concept in Search of a Case?" Journal of Interamerican Studies and World Affairs 34, no. 4 (1992): 119–94. http://dx.doi.org/10.2307/165808.

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The Literature on democratic transitions suggests two opposite sorts of dangers that the successful democratizer must avoid: too much uncertainty on the one hand, and too little on the other. The first can lead to conflict, violence, and abortive transitions (Karl and Schmitter, 199D; while the second means there is no democracy at all, but leads to something less which has been variously called: "tutelary democracy," "electoralism," or "democradura."Before the government of Patricio Aylwin took office in Chile in March 1990, most observers anticipated that the return to democracy would bring
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Scott, Ian A. "Public hospital bed crisis: too few or too misused?" Australian Health Review 34, no. 3 (2010): 317. http://dx.doi.org/10.1071/ah09821.

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•Increasing demand on public hospital beds has led to what many see as a hospital bed crisis requiring substantial increases in bed numbers. By 2050, if current bed use trends persist and as the numbers of frail older patients rise exponentially, a 62% increase in hospital beds will be required to meet expected demand, at a cost almost equal to the entire current Australian healthcare budget. •This article provides an overview of the effectiveness of different strategies for reducing hospital demand that may be viewed as primarily (although not exclusively) targeting the hospital sector – incr
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7

Barnes, Josephine, and Nick C. Fox. "The search for early markers of AD: hippocampal atrophy and memory deficits." International Psychogeriatrics 26, no. 7 (2014): 1065–66. http://dx.doi.org/10.1017/s1041610214000623.

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There is increasing interest in finding markers of Alzheimer's disease (AD) that are discriminative even at an early, pre-dementia stage. This interest is driven partly by a desire to improve clinical diagnosis in more mildly affected individuals, and also by the recent paradigm shift in thinking about clinical trials for AD. This shift is a result of concern that the recent failures of high-profile clinical trials conducted in patients with mild to moderate AD may have been because therapy was “too little, too late.” The implication being that if only treatments had been trialled earlier they
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8

Audi, Robert. "The Ethics of Belief and the Morality of Action: Intellectual Responsibility and Rational Disagreement." Philosophy 86, no. 1 (2010): 5–29. http://dx.doi.org/10.1017/s0031819110000586.

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AbstractThe contemporary explosion of information makes intellectual responsibility more needed than ever. The uncritical tend to believe too much that is unsubstantiated; the overcritical tend to believe too little that is true. A central problem for this paper is to formulate standards to guide an intellectually rigorous search for a mean between excessive credulity and indiscriminate skepticism. A related problem is to distinguish intellectual responsibility for what we believe from moral responsibility for what we do. A third problem is how to square intellectual responsibility in retainin
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9

Rudis, Gediminas. "Lithuania’s search for International support to Resist Russian Aggression in 1918." Lithuanian Historical Studies 5, no. 1 (2000): 161–75. http://dx.doi.org/10.30965/25386565-00501009.

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The paper rejects a viewpoint prevalent among Lithuanian historians that the first government of the Republic of Lithuania, led by Augustinas Voldemaras, did not recognize the danger of Russia and was not concerned with the security of the state. Research shows that the government was fully conscious of the international situation of Lithuania and expected efficient diplomatic and military support from the Allies to counter Russian aggression. The orientation to the Allied powers was well-grounded, but too little attention was paid to the mobilization of the internal resources for the defence
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10

Walser, Hannah. "Proust's Genies: In Search of Lost Time and Population Biology." Novel 51, no. 3 (2018): 482–501. http://dx.doi.org/10.1215/00295132-7086517.

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Abstract Whether identified as “genies,” “little men,” or simply “les moi,” a vast horde of personified mental faculties populates In Search of Lost Time, responsible for behaviors too instantaneous or too ingrained to come under conscious control. Representing automatic neural subroutines as self-interested beings allows Proust to apply the principles of biological selection to these psychological entities, imagining the mind as an ecosystem in which great personal upheavals—for instance, Marcel's loss of Albertine—figure as extinction events that wipe out large populations of narrowly specia
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11

Sachse, Jacqueline. "The influence of snippet length on user behavior in mobile web search." Aslib Journal of Information Management 71, no. 3 (2019): 325–43. http://dx.doi.org/10.1108/ajim-07-2018-0182.

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Purpose Web search is more and more moving into mobile contexts. However, screen size of mobile devices is limited and search engine result pages face a trade-off between offering informative snippets and optimal use of space. One factor clearly influencing this trade-off is snippet length. The purpose of this paper is to find out what snippet size to use in mobile web search. Design/methodology/approach For this purpose, an eye-tracking experiment was conducted showing participants search interfaces with snippets of one, three or five lines on a mobile device to analyze 17 dependent variables
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12

Durrant, Joseph, Hugh Rickards, and Andrea E. Cavanna. "Prognosis and Outcome Predictors in Psychogenic Nonepileptic Seizures." Epilepsy Research and Treatment 2011 (February 9, 2011): 1–7. http://dx.doi.org/10.1155/2011/274736.

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It is estimated that one in five patients referred to specialist epilepsy clinics for refractory seizures have psychogenic nonepileptic seizures (PNES). Despite the high prevalence, little is known about the prognosis of patients with PNES. In this paper we set out to systematically assess published original studies on the prognosis and outcome predictors of patients with PNES. Our literature search across the databases Medline, PsycINFO, and EMBASE generated 18 original studies meeting the search criteria. Prognosis was found to be poor in adults, but good in children. Predictors of poor outc
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Drake, F. D., George Marx, N. D. Papagiannis, et al. "51. Bioastronomy - Search for Extraterrestrial Life: Bioastronomie - Recherche De La Vie Dans L’univers." Transactions of the International Astronomical Union 20, no. 1 (1988): 693–701. http://dx.doi.org/10.1017/s0251107x00007598.

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The past three years have seen not only a growth in the activities of our commission, but an extension of its activities into important areas which have heretofore motivated too little activity. Of particular interest have been the many activities directed towards elucidating the question of the abundance of extrasolar planetary systems. There have been a number of observations showing the presence of disks of dust around nearby stars, disks which fit the idea that stars are often formed with an accompanying disk of dust which may in many or perhaps all cases produce a planetary system. Infra-
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Lewis, B. M. "IR and masing properties of bright IRAS sources." Symposium - International Astronomical Union 180 (1997): 357. http://dx.doi.org/10.1017/s0074180900131328.

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Comparisons between color-color diagrams of OH/IR stars with/out IR flux and/or galactic position constraints show that little of the color dispersion is innate: the most precise colors come from high flux samples away from the Galactic Center. It is advantageous to delineate the color range of O-rich shells by only color selecting objects in the IRAS Point Source Catalog (PSC) with S(25) > 100 Jy, which yields 333 objects. All but 2 of these have published LRS spectra, which often suffice to determine whether an object is carbon or oxygen rich. About 80% of them have been searched for 1612
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15

Leese, Henry J., Thozhukat Sathyapalan, Victoria Allgar, Daniel R. Brison, and Roger Sturmey. "Going to extremes: the Goldilocks/Lagom principle and data distribution." BMJ Open 9, no. 11 (2019): e027767. http://dx.doi.org/10.1136/bmjopen-2018-027767.

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Numerical data in biology and medicine are commonly presented as mean or median with error or confidence limits, to the exclusion of individual values. Analysis of our own and others’ data indicates that this practice risks excluding ‘Goldilocks’ effects in which a biological variable falls within a range between ‘too much’ and ‘too little’ with a region between where its function is ‘just right’; a concept captured by the Swedish term ‘Lagom’. This was confirmed by a narrative search of the literature using the PubMed database, which revealed numerous relationships of biological and clinical
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Mouton, Michelle. "Missing, Lost, and Displaced Children in Postwar Germany: The Great Struggle to Provide for the War's Youngest Victims." Central European History 48, no. 1 (2015): 53–78. http://dx.doi.org/10.1017/s0008938915000035.

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AbstractIn the final months of World War II, more than a million German children took to the roads in search of family and home. Although the majority returned home with little institutional support, hundreds of thousands of other German children could not. Some were orphaned; others remained in camps, children's homes, or foster families in areas that no longer belonged to Germany. Most challenging for authorities were those who were alone and too young to know their own names. This article explores the struggle to locate, identify, and provide for missing, lost, and displaced German children
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17

Parker, Daisy, Richard Byng, Chris Dickens, Debbie Kinsey, and Rose McCabe. "Barriers and facilitators to GP–patient communication about emotional concerns in UK primary care: a systematic review." Family Practice 37, no. 4 (2020): 434–44. http://dx.doi.org/10.1093/fampra/cmaa002.

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Abstract Background In the UK, general practitioners (GPs) are the most commonly used providers of care for emotional concerns. Objective To update and synthesize literature on barriers and facilitators to GP–patient communication about emotional concerns in UK primary care. Design Systematic review and qualitative synthesis. Method We conducted a systematic search on MEDLINE (OvidSP), PsycInfo and EMBASE, supplemented by citation chasing. Eligible papers focused on how GPs and adult patients in the UK communicated about emotional concerns. Results were synthesized using thematic analysis. Res
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18

Cross, Donald. "Cartesian “Riddles”." Essays in Philosophy 13, no. 1 (2012): 6–30. http://dx.doi.org/10.5840/eip20121312.

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Traditionally, ‘René Descartes’ is synonymous with ‘method.’ The so-called father of modern science, he is perhaps the systematic and methodological philosopher par excellence, a fundamental motivation for his attempt to secede from contemporary thought being the possibility of establishing a universally valid method in the search for truth. In a passage in the Rules for the Direction of the Mind, Descartes contrasts his method with what he calls scholastic “[r]iddles,” verbal equivocations that hinder the acquisition of knowledge. In this paper I analyze this notion of riddling and the Cartes
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19

Landstreet, John D., and Stefano Bagnulo. "Discovery of a Sirius-like binary system with a very strongly magnetic white dwarf." Astronomy & Astrophysics 634 (February 2020): L10. http://dx.doi.org/10.1051/0004-6361/201937301.

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Non-interacting binary systems containing a magnetic white dwarf and a main-sequence star are considered extremely rare, perhaps non-existent. In the course of a search of magnetic fields in high-mass white dwarfs we have discovered a Sirius-like wide binary system composed of a main-sequence G0 star and an M ∼ 1.1 M⊙ white dwarf with a huge (hundreds of MG) magnetic field. This star, WDS J03038+0608B, shows a circular polarisation amplitude of 5% in the continuum, with no evidence of variability on a 1 d timescale, little or no linear polarisation in the blue part of the spectrum, and about 2
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20

Fijn, Lisa B., F. Josef van der Staay, Vivian C. Goerlich-Jansson, and Saskia S. Arndt. "Importance of Basic Research on the Causes of Feather Pecking in Relation to Welfare." Animals 10, no. 2 (2020): 213. http://dx.doi.org/10.3390/ani10020213.

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Feather pecking is a prominent issue in the commercial egg industry, associated with economic losses and welfare problems. A non-systematic literature search suggests that studies on feather pecking are predominantly concerned with applied research goals. That is to say, they aim to solve or diminish the effects of this problematic behavior by orienting towards practical approaches. The strong emphasis on this research approach has skewed our knowledge of the causes of feather pecking in relation to welfare. While the need for such research is high, there is an equivalent need for basic resear
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21

Stimpson, Nicola, Niruj Agrawal, and Glyn Lewis. "Randomised controlled trials investigating pharmacological and psychological interventions for treatment-refractory depression." British Journal of Psychiatry 181, no. 4 (2002): 284–94. http://dx.doi.org/10.1192/bjp.181.4.284.

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BackgroundAbout 30% of people with depression do not respond to an antidepressant at the recommended dose and can be described as having treatment-refractory depression.AimsTo summarise the findings from all randomised controlled trials (RCTs) that have assessed the efficacy of a pharmacological or psychological intervention for treatment-refractory depression.MethodWe used a systematic search strategy to identify RCTs that included adults aged 18–75 years with a diagnosis of unipolar depression that had not responded to a 4-week course of a recommended dose of an antidepressant.ResultsWe iden
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22

Groves, Julian M., and Annie Hau-nung Chan. "Love in the time of ‘settling’: Forbidden knowledge and modern singles advice." Journal of Sociology 54, no. 1 (2017): 141–55. http://dx.doi.org/10.1177/1440783317721351.

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While there has been much feminist criticism over recent discourses that stigmatize single women, little is known about how women actually consume and respond to the advice prescribed in this discourse. This article addresses this shortcoming by looking at a controversy that emerged in Hong Kong over a popular television show that dispensed dating advice to single women. Based on focus group discussions about the show with 39 unwed women, we examine how women negotiate sexist modern dating advice in relation to their normative views about courtship. Using analogies drawn from the sociology of
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23

Shook, John R. "Are People Born to be Believers, or are Gods Born to be Believed?" Method and Theory in the Study of Religion 29, no. 4-5 (2017): 353–73. http://dx.doi.org/10.1163/15700682-12341389.

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AbstractProposals that god-belief is an innate capacity of all humanity have not been confirmed by empirical studies. Scientific disciplines presently lean against god-belief’s innateness. Perhaps religion should be relieved that belief in gods is not innate. Intuitive cognitive functions supporting god-belief offer little convergence upon any god. Religious pluralism back to the Stone Age displays no consensus either. Any cognition for god-belief can only be deemed as mostly or entirely misleading. Theology has tried to forestall that skeptical judgment, by dictating what counts as authentic
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Hayward, Matt W. "The Natural History of Sydney." Pacific Conservation Biology 17, no. 4 (2011): 378. http://dx.doi.org/10.1071/pc110378.

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AUSTRALIA’S relatively recent discovery by Europeans and rapid loss of traditional knowledge without documentation means the accumulated knowledge of our natural history is scant compared to other continents (e.g., search for publications on the top-order predators of each continent for confirmation). Yet, as Mike Archer highlights in the Foreword to this book, this natural history information is fundamental for us to develop effective conservation strategies. Instead of focusing on accumulating this information, the competitive nature of academia limits the value of publishing simple natural
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N. Bolton, Ruth, Anders Gustafsson, Janet McColl-Kennedy, Nancy J. Sirianni, and David K. Tse. "Small details that make big differences." Journal of Service Management 25, no. 2 (2014): 253–74. http://dx.doi.org/10.1108/josm-01-2014-0034.

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Purpose – Service organizations and marketers have focussed too much of their energy on their core service's performance and too little emphasis on designing a customer journey that enhances the entire customer experience. There is nothing wrong with firms seeking continuous improvement in service quality and customer satisfaction. These efforts are needed for firms to be competitive in the marketplace. The problem occurs when performance levels and service offerings become too similar within an industry, so that price is the only competitive weapon that remains. The purpose of this paper is t
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Georgakouli, Kalliopi, Ioannis G. Fatouros, Dimitrios Draganidis, et al. "Exercise in Glucose-6-Phosphate Dehydrogenase Deficiency: Harmful or Harmless? A Narrative Review." Oxidative Medicine and Cellular Longevity 2019 (April 4, 2019): 1–7. http://dx.doi.org/10.1155/2019/8060193.

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Objectives. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, theoretically, renders red blood cells (RBC) susceptible to oxidative stress. G6PD deficiency has also been found in other types of cells than RBC, such as leukocytes and myocytes, where an inefficient protection against oxidative stress may occur too. Glutathione (GSH), a significant antioxidant molecule, levels are lower in G6PD individuals, and theoretically, the probability of oxidative stress and haemolysis due to exercise in individuals with G6PD deficiency is increased, whereas dietary supplementation with antioxidants may
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Lavoie, Kim L., and Richard P. Fleet. "Should Psychologists Be Granted Prescription Privileges? A Review of the Prescription Privilege Debate for Psychiatrists." Canadian Journal of Psychiatry 47, no. 5 (2002): 443–49. http://dx.doi.org/10.1177/070674370204700505.

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Background: The debate over whether clinical psychologists should be granted the right to prescribe psychoactive medication has received considerable attention over the last 2 decades in the US, but there has been relatively little discussion of this controversial topic among Canadian mental health professionals, namely psychologists and psychiatrists. Proponents of prescription privileges (PPs), including the American Psychological Association (APA), argue that psychologists do not and cannot function as independent professionals because the medical profession places many restrictions on thei
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Berger, Lawrence M., Giulia Ferrari, Marion Leturcq, Lidia Panico, and Anne Solaz. "COVID-19 lockdowns and demographically-relevant Google Trends: A cross-national analysis." PLOS ONE 16, no. 3 (2021): e0248072. http://dx.doi.org/10.1371/journal.pone.0248072.

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The spread of COVID-19 and resulting local and national lockdowns have a host of potential consequences for demographic trends. While impacts on mortality and, to some extent, short-term migration flows are beginning to be documented, it is too early to measure actual consequences for family demography. To gain insight into potential future consequences of the lockdown for family demography, we use cross-national Google Trends search data to explore whether trends in searches for words related to fertility, relationship formation, and relationship dissolution changed following lockdowns compar
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29

Lewanzik, Daniel, and Holger R. Goerlitz. "Task-dependent vocal adjustments to optimize biosonar-based information acquisition." Journal of Experimental Biology 224, no. 1 (2020): jeb234815. http://dx.doi.org/10.1242/jeb.234815.

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ABSTRACTAnimals need to acquire adequate and sufficient information to guide movements, yet information acquisition and processing are costly. Animals thus face a trade-off between gathering too little and too much information and, accordingly, actively adapt sensory input through motor control. Echolocating animals provide a unique opportunity to study the dynamics of adaptive sensing in naturally behaving animals, as every change in the outgoing echolocation signal directly affects information acquisition and the perception of the dynamic acoustic scene. Here, we investigated the flexibility
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Santamaría, Patricia G., Gema Moreno-Bueno, and Amparo Cano. "Contribution of Epithelial Plasticity to Therapy Resistance." Journal of Clinical Medicine 8, no. 5 (2019): 676. http://dx.doi.org/10.3390/jcm8050676.

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Therapy resistance is responsible for tumour recurrence and represents one of the major challenges in present oncology. Significant advances have been made in the understanding of the mechanisms underlying resistance to conventional and targeted therapies improving the clinical management of relapsed patients. Unfortunately, in too many cases, resistance reappears leading to a fatal outcome. The recent introduction of immunotherapy regimes has provided an unprecedented success in the treatment of specific cancer types; however, a good percentage of patients do not respond to immune-based treat
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Luijten, Maartje, Matt Field, and Ingmar H. A. Franken. "Pharmacological interventions to modulate attentional bias in addiction." CNS Spectrums 19, no. 3 (2013): 239–46. http://dx.doi.org/10.1017/s1092852913000485.

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Attentional bias in substance-dependent patients is the tendency to automatically direct attention to substance-related cues in the environment. Preclinical models suggest that attentional bias emerges as a consequence of dopaminergic activity evoked by substance-related cues. The aim of the current review is to describe pharmacological mechanisms underlying attentional bias in humans and to critically review empirical studies that aimed to modulate attentional bias in substance-dependent patients by using pharmacological agents. The findings of the reviewed studies suggest that attentional bi
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Zhao, Rongmei, Xi Xiong, Xia Zu, Shenggen Ju, Zhongzhi Li, and Binyong Li. "A Hierarchical Attention Recommender System Based on Cross-Domain Social Networks." Complexity 2020 (August 12, 2020): 1–13. http://dx.doi.org/10.1155/2020/9071624.

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Search engines and recommendation systems are an essential means of solving information overload, and recommendation algorithms are the core of recommendation systems. Recently, the recommendation algorithm of graph neural network based on social network has greatly improved the quality of the recommendation system. However, these methods paid far too little attention to the heterogeneity of social networks. Indeed, ignoring the heterogeneity of connections between users and interactions between users and items may seriously affect user representation. In this paper, we propose a hierarchical
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Mehta, Nisha S., Oliver T. Mytton, Edward W. S. Mullins, et al. "SARS-CoV-2 (COVID-19): What Do We Know About Children? A Systematic Review." Clinical Infectious Diseases 71, no. 9 (2020): 2469–79. http://dx.doi.org/10.1093/cid/ciaa556.

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Abstract Background Few pediatric cases of coronavirus disease 2019 (COVID-19) have been reported and we know little about the epidemiology in children, although more is known about other coronaviruses. We aimed to understand the infection rate, clinical presentation, clinical outcomes, and transmission dynamics for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in order to inform clinical and public health measures. Methods We undertook a rapid systematic review and narrative synthesis of all literature relating to SARS-CoV-2 in pediatric populations. The search terms also incl
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Alves, Daniele Evelin, Wendy Nilsen, Silje Christine Reistad Fure, et al. "What characterises work and workplaces that retain their employees following acquired brain injury? Systematic review." Occupational and Environmental Medicine 77, no. 2 (2020): 122–30. http://dx.doi.org/10.1136/oemed-2019-106102.

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ObjectivesThe objective of this study was to conduct a systematic review assessing workplace factors related to work retention (or return to work) in employees with acquired brain injury (ABI). Additionally, we aimed to synthesise the evidence and state of knowledge on this subject.MethodsA database search was performed in nine relevant electronic databases. Inclusion criteria were quantitative peer-reviewed publications empirically investigating the relationship between work/workplace factors and work retention in employees following ABI. The methodological quality was determined by Effective
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Gupta, Rohtash Chand, and Tirshem Kumar Kaushik. "Spectrum of threats to nests of Yellow-wattled Lapwing Vanellus malabaricus in Kurukshetra outskirts-a case study." Journal of Applied and Natural Science 4, no. 1 (2012): 75–78. http://dx.doi.org/10.31018/jans.v4i1.226.

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It is one thing that Red-wattled Lapwing Vanellus indicus is, rather a common bird on the outskirts of wheat harvested fields in outskirts of Kurukshetra, yet, Yellow-wattled Lapwing V. malabaricus (Boddaert, 1783) is an uncommon bird and seen rarely and that too with efforts and serious search. On the top of this, the bird is confronting most difficult conditions for its even rare existence. It is characterized by the presence of bright Yellow fleshy lappets above and in front of eyes. Black wings show off a white bar in flight. It has a little shorter staturecompared with that of Red-wattled
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Chang, Jung-San, Kuo-Chih Wang, Hong-Wen Liu, Mei-Chun Chen, Lien-Chai Chiang, and Chun-Ching Lin. "Sho-Saiko-To (Xiao-Chai-Hu-Tang) and Crude Saikosaponins Inhibit Hepatitis B Virus in a Stable HBV-Producing Cell Line." American Journal of Chinese Medicine 35, no. 02 (2007): 341–51. http://dx.doi.org/10.1142/s0192415x07004862.

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To search for an effective antiviral agent, this study tested the hypothesis that sho-saiko-to (Xiao-Chai-Hu-Tang) and crude saikosaponins possess the activity directly against HBV and could affect the expressions of viral antigens, HBeAg and HBsAg, in HepG2 2.2.15 cell model. The viral amount and viral antigens in the suspension were estimated by quantitative real time PCR and enzyme-linked immunosorbent assay (ELISA), respectively. The results showed that sho-saiko-to could inhibit the production of HBV (p < 0.0001), 20 μg/ml sho-saiko-to was efficacious at day-3 of treatment and 10 μg/ml
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Wever, Kimberley E., Florentine J. Geessink, Michelle A. E. Brouwer, Alice Tillema, and Merel Ritskes-Hoitinga. "A systematic review of discomfort due to toe or ear clipping in laboratory rodents." Laboratory Animals 51, no. 6 (2017): 583–600. http://dx.doi.org/10.1177/0023677217705912.

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Toe clipping and ear clipping (also ear notching or ear punching) are frequently used methods for individual identification of laboratory rodents. These procedures potentially cause severe discomfort, which can reduce animal welfare and distort experimental results. However, no systematic summary of the evidence on this topic currently exists. We conducted a systematic review of the evidence for discomfort due to toe or ear clipping in rodents. The review methodology was pre-specified in a registered review protocol. The population, intervention, control, outcome (PICO) question was: In rodent
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Millar, Samuel J., and Ana Miorelli. "#3115 Systematic review into the effects of sleep disorders on the development of PTSD." Journal of Neurology, Neurosurgery & Psychiatry 92, no. 8 (2021): A15.1—A15. http://dx.doi.org/10.1136/jnnp-2021-bnpa.33.

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ObjectivesTo examine if sleep problems act as a risk factor for future PTSD development in military, child, and general adult demographics. We will also be examining specific sleep disorders, such as nightmares and insomnia, as well as examining general sleep complaints in a series of sub-sections (REM sleep, Sleep duration, quality, latency, and maintenance) to see if it is possible with the current literature to discover potential hints into the development of PTSD.MethodsSix databases (Medline, Embase, Web of Science, Psych info, AMED, and OpenGray) were searched with a standardised search
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Brumback, Richard A. "Teaching Public Administration in a Post-Literate Society." Political Science Teacher 1, no. 2 (1988): 1–4. http://dx.doi.org/10.1017/s0896082800000131.

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As we move farther into a condition of “post literacy” in our society (a condition where reading and writing have been displaced by television and video as the primary sources of mass entertainment and communication), the problem of students entering universities and even graduate programs with substandard communication skills is becoming more pronounced.In addressing the problem, despite frequent references to the “art and science of public administration,” there seems to be far too little emphasis on communication skills. Most public administration schools concentrate on the behavioral and m
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Freymond, Jacques. "By Way of Conclusion." Government and Opposition 23, no. 1 (1988): 103–8. http://dx.doi.org/10.1017/s0017257x00017036.

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THROUGHOUT THE TWO-DAY DEBATE OF OUR SYMPOSIUM we did our best to answer a challenging and I would say tricky question: can the Confederado Helvetica be imitated? I do not think that the Swiss who were present considered their country as a model at all. They tried to establish and to maintain a certain distance from the object of their study and to refrain from the reference — too often used — to a so-called special Swiss case. They were no apologists but honest witnesses.Personally, I would make an evaluation of my country from a slightly different angle. My enquiry, therefore, would be focus
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Donaghy, P. C., J. T. O'Brien, and A. J. Thomas. "Prodromal dementia with Lewy bodies." Psychological Medicine 45, no. 2 (2014): 259–68. http://dx.doi.org/10.1017/s0033291714000816.

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BackgroundThe clinical condition of dementia is now recognized as a diagnosis that can only be applied too late in the disease process to be useful for therapeutic approaches centring on disease modification. As a result, in recent years increasing attention has been given to mild cognitive impairment (MCI) and the diagnosis of prodromal dementia. This paper reviews the evidence for the clinical presentation of prodromal dementia with Lewy bodies (DLB).MethodA Medline search was carried out to identify articles with original data on the prodromal presentation of DLB.ResultsIn MCI cohorts that
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Latif, Khawaja Fawad, and Frederic Marimon. "Development and validation of servant leadership scale in Spanish higher education." Leadership & Organization Development Journal 40, no. 4 (2019): 499–519. http://dx.doi.org/10.1108/lodj-01-2019-0041.

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PurposeThe purpose of this paper is twofold. First is the validation of a scale to measure the servant leadership of the university leaders. Second is to analyze how servant leadership affects the career satisfaction and life satisfaction of the academics.Design/methodology/approachUsing a survey of 148 academics at universities located in Spain collected in May 2018, a couple of models were conducted using structural equation model techniques: a confirmatory factor analysis of second order in order to assess the leadership scale and a mediation model to assess how servant leadership impacts o
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Weggelaar-Jansen, Anne Marie J. W. M., Damien S. E. Broekharst, and Martine de Bruijne. "Developing a hospital-wide quality and safety dashboard: a qualitative research study." BMJ Quality & Safety 27, no. 12 (2018): 1000–1007. http://dx.doi.org/10.1136/bmjqs-2018-007784.

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BackgroundSeveral countries have national policies and programmes requiring hospitals to use quality and safety (QS) indicators. To present an overview of these indicators, hospital-wide QS (HWQS) dashboards are designed. There is little evidence how these dashboards are developed. The challenges faced to develop these dashboards in Dutch hospitals were retrospectively studied.Methods24 focus group interviews were conducted: 12 with hospital managers (n=25; 39.7%) and 12 support staff (n=38; 60.3%) in 12 of the largest Dutch hospitals. Open and axial codings were applied consecutively to analy
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Huygebaert, Bruno. "Tussen geschiedenis en history. Slotbeschouwingen door de moderator." WT. Tijdschrift over de geschiedenis van de Vlaamse beweging 70, no. 2 (2011): 129–39. http://dx.doi.org/10.21825/wt.v70i2.12316.

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De toenemende dominantie van het Engels als mondiale wetenschapstaal – in combinatie met de voortschrijdende digitalisering – wordt te snel als vanzelfsprekend beschouwd. Ook de historiografie in de Lage Landen heeft hieronder te lijden. Het dwingt historici in het keurslijf van internationale rankingsystemen, die te weinig oog hebben voor de eigenheid van het Nederlandse taalgebied. Het is de verdienste van Wetenschappelijke tijdingen om naar aanleiding van het 75-jarig bestaan van het tijdschrift een breed debat te hebben georganiseerd, waaraan verschillende toonaangevende publicaties deelna
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Leigh, Leonard H. "Vers une réforme des pouvoirs de la police en Angleterre." Les Cahiers de droit 20, no. 3 (2005): 583–601. http://dx.doi.org/10.7202/042329ar.

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The author discusses certain reforms to the law of police powers which are currently being demanded by the English police. He notes that the English police have long acted under a regime of limited powers. These have proven to be irksome, but they have also conduced to a regime under which the police use the minimum powers possible and rely considerably on public support in the fight against crime. The police however urge that further powers are necessary, notably powers to stop and question persons in public places and to hold arrested persons for interrogation concerning the commission of of
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Lehner, Kurt R., and Michael Schulder. "American views of Sir Victor Horsley in the era of Cushing." Journal of Neurosurgery 130, no. 2 (2019): 639–48. http://dx.doi.org/10.3171/2017.8.jns171438.

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Sir Victor Horsley was a pioneering British neurosurgeon known for his numerous neurosurgical, scientific, and sociopolitical contributions. Although word of these surgical and scientific achievements quickly spread throughout Europe and North America in the late 19th century, much of modern neurosurgery’s view of Horsley has been colored by a single anecdote from John Fulton’s biography of Harvey Cushing. In this account, Cushing observes a frenetic Horsley hastily removing a Gasserian ganglion from a patient in the kitchen of a British mansion. Not long after, Cushing left Britain saying tha
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., Abimaje, Joshua ., Mohd Zin Bin Kandar, and Dodo Yakubu Aminu. "Light Shelf as a Daylighting System in a Tropical Climate Office Space." International Journal of Engineering & Technology 7, no. 2.29 (2018): 798. http://dx.doi.org/10.14419/ijet.v7i2.29.14259.

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Daylighting is a passive design strategy for lighting office spaces given the fact that offices operate within daytime, usually between 8:00 am to 5:00 pm which corresponds to the period of daylight availability. Daylight is abundant in the tropics, free and has no negative impact on the environment. It has positive physiological and psychological effect on the man as well as good colour rendering. Ironically, despite the abundant availability and the merits of daylighting especially in the tropics, it is not fully utilized. A light shelf is one of the innovative daylighting systems that can b
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Woolbright, Lauren. "Environmental Game Design as Activism // El diseño del juego medioambiental como activismo." Ecozon@: European Journal of Literature, Culture and Environment 8, no. 2 (2017): 88–102. http://dx.doi.org/10.37536/ecozona.2017.8.2.1350.

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The disconnect between climate activists and their skeptical audience is a multipart communication challenge of representing the unrepresentable. Even if we accept climate change as reality, enormous barriers stand between humans and effective action, the first being a crisis of imagination: climate change is too big for representation, scholars such as Morton (2013) and Marshall (2014) have argued. This paper examines games that have taken climate-related themes into account and analyzes them in search of resonant design elements that might work to communicate about climate change. Focusing p
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Rosian-Schikuta, Ingrid, Julia Bobek, Anja Laschkolnig, et al. "OP01 Cross Border Cooperation On High-Cost-Capital Investments In Health." International Journal of Technology Assessment in Health Care 33, S1 (2017): 1. http://dx.doi.org/10.1017/s026646231700112x.

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INTRODUCTION:The medical equipment sector is characterized by a large share of overall health budgets spent for the provision of capital investment goods such as medical scanners and radiotherapy units. A high variability in provision and utilization rates of medical equipment can be observed too. The objective for this study was to contribute to effective cross-border cooperation between European Union (EU)-Member States by pooling resources for high-cost medical equipment investments (1).METHODS:Potential cost-intensive and highly specialised medical equipment, where cross-border investment
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Tagliacozzo, Eric. "The Long Struggle to Master the Monsoon." Current History 118, no. 807 (2019): 157–59. http://dx.doi.org/10.1525/curh.2019.118.807.157.

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