Academic literature on the topic 'Séc. 18-19'
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Journal articles on the topic "Séc. 18-19"
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Kaliki, Swathi, Nandini Bothra, Kavya Madhuri Bejjanki, Arpita Nayak, George Ramappa, Ashik Mohamed, Tarjani Vivek Dave, Mohammad Javed Ali, and Milind N. Naik. "Malignant Eyelid Tumors in India: A Study of 536 Asian Indian Patients." Ocular Oncology and Pathology 5, no. 3 (September 13, 2018): 210–19. http://dx.doi.org/10.1159/000491549.
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Purpose: To study the proportion of eyelid malignant tumors in an Asian Indian population and to review their clinical features and outcomes. Methods: This is a retrospective study of 536 patients. Results: The mean age at presentation with eyelid malignancy was 58 years. Histopathology-proven diagnoses of these patients included sebaceous gland carcinoma (SGC) (n = 285, 53%), basal cell carcinoma (BCC) (n = 128, 24%), squamous cell carcinoma (SCC) (n = 99, 18%), and miscellaneous tumors (n = 24, 4%). The statistically significant differences between eyelid malignant tumors included age at presentation, tumor location, and tumor extent. The clinicopathological correlation of SGC, BCC, SCC, and miscellaneous tumors was 91, 86, 46, and 38% (p = 0.001), respectively. Comparing SGC with BCC, SCC, and miscellaneous tumors, SGC was more commonly associated with tumor recurrence (21 vs. 3, 8, and 13%; p = 0.001), systemic metastasis (13 vs. 0, 4, and 13%; p = 0.001), and death (9 vs. 0, 4, and 0%; p = 0.004). Compared to SGC, BCC, and SCC, locoregional lymph node metastasis was more common with miscellaneous tumors (26 vs. 16, < 1, and 8%; p = 0.001) over a mean follow-up period of 19 months. Conclusion: In Asian Indians, SGC is twice as common as BCC and 3 times more common than SCC. SGC is associated with poorer prognosis compared to other eyelid malignant tumors.
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Deutschbein, Timo, Nicole Unger, Jakob Hinrichs, Martin K. Walz, Klaus Mann, and Stephan Petersenn. "Late-night and low-dose dexamethasone-suppressed cortisol in saliva and serum for the diagnosis of cortisol-secreting adrenal adenomas." European Journal of Endocrinology 161, no. 5 (November 2009): 747–53. http://dx.doi.org/10.1530/eje-09-0517.
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ObjectiveIn patients with adrenal incidentalomas, hormonally active masses need to be considered, particularly cortisol-producing adenomas (CPA), aldosterone-producing adenomas, and pheochromocytomas. The screening for hypercortisolism relies on confirming excess cortisol secretion and insufficient suppression after dexamethasone. Because of its high correlation with free cortisol and its stress-free collection, salivary cortisol (SaC) may offer advantages over serum cortisol (SeC). We evaluated the value of SaC and SeC for the diagnosis of CPA.DesignComparative study between 2001 and 2006.MethodsThirty-eight patients with confirmed CPA were compared with 18 healthy subjects as well as 48 control patients suffering from aldosterone-producing adenomas (n=13), pheochromocytomas (n=16), or nonfunctioning adenomas (n=19). Sampling of saliva and serum was performed at 2300 and at 0800 h following low-dose dexamethasone suppression. Receiver operating characteristics analysis was used to calculate thresholds with at least 95% sensitivity for CPA.ResultsRegarding the cutoffs for late-night cortisol, SaC (4.8 nmol/l, sensitivity 97%, specificity 69%) was slightly more specific than SeC (115 nmol/l, sensitivity 97%, specificity 63%). In contrast, the cutoff for dexamethasone-suppressed SaC (3.7 nmol/l, sensitivity 97%, specificity 83%) was slightly less specific than SeC (94 nmol/l, sensitivity 97%, specificity 88%). However, the latter cutoffs demonstrated greater specificity when compared with the cutoffs for late-night cortisol.ConclusionThe diagnostic accuracy of SaC is as good as SeC. Owing to its higher specificity, dexamethasone-suppressed cortisol is preferable to late-night cortisol when screening for Cushing's syndrome in patients with adrenal incidentalomas.
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Cometi, L., G. Bandini, K. El Aoufy, A. Domanico, L. Tofani, C. Bruni, S. Bellando Randone, et al. "OP0176 ULTRASOUND (US) EVALUATION OF BOWEL VASCULOPATHY IN SYSTEMIC SCLEROSIS (SSC)." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 105.2–106. http://dx.doi.org/10.1136/annrheumdis-2021-eular.647.
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Background:Gastrointestinal involvement is one of the most frequent features of SSc, affecting nearly 90% of patients, with a great impact on quality of life and morbidity. One of the key pathological factors of SSc bowel involvement is vasculopathy (1), although little is known about its pathophysiology and no treatments are currently available.Objectives:to assess with abdominal US the superior mesenteric artery (SMA) and the inferior mesenteric artery (IMA) vessel characteristics and blood flow in SSc, compared to healthy controls (HC).Methods:we performed fasting abdominal US in SSc patients fulfilling the ACR/EULAR 2013 classification criteria and HC. Patients with a history of peripheral /coronary arterial disease were excluded. For both SMA and IMA, caliber (mm), Peak Systolic Velocity – PSV (cm/sec), Reverse Velocity – RV (cm/sec), End-Diastolic Velocity – EDV (cm/sec), Mean Velocity – mV (cm/sec), Blood-flow (cm/sec), Resistive Index – RI and Pulsatility Index – PI were measured.Results:28 SSc patients [25 females (89.3%), mean age 48.75 ± 12.39 years; 6 (22.22%) anti-centromere and 19 (70.37%) positive for anti-topoisomerase I antibodies] and 28 HC [18 females (64.3%), mean age 36.25 ± 12.08 years] were evaluated. In SSc, the SMA caliber was significantly smaller than in HC (5.75 ± 0.62 vs. 6.45 ± 0.60 mm, p<0.0001), while IMA dimensions did not differ.The SMA study revealed SSc patients had a significant reduction of RV (7.25 ± 6.37 vs. 18.52 ± 6.16 cm/sec, p<0.0001) and PI (3.33 ± 0.75 vs. 4.53 ± 1.03, p<0.0001) when compared to HC. In addition, in SSc the mV of SMA was significantly lower than in HC (38.03 ± 13.90 vs. 28.32 ±9.25 cm/sec, p=0.0035), as well as the RI (0.88 ± 0.04 vs. 0.91 ± 0.03, p=0.0034); EDV was significantly increased (16.34 ± 7.03 vs. 12.64 ± 5.46 cm/sec, p=0.0321). Similarly to SMA, also in IMA RV and PI were significantly lower that controls (RV: 2.69 ± 6.10 vs. 17.06 ± 5.75 cm/sec, p<0.0001; PI: 3.54 ± 0.95 vs. 6.08 ± 1.53, p<0.0001). Moreover SSc patients presented a significant reduction of PSV and RI of IMA (PSV: 72.27 ± 27.23 vs. 93.81 ± 25.73 cm/sec, p=0.0084; RI: 0.88 ± 0.04 vs. 0.91 ± 0.03, p=0.0132) when compared to HC. Although the HC group was significantly younger than the SSc group (p=0.0003), all the results were confirmed after adjustment for age (Table 1).Table 1.comparison of the characteristics of SMA and IMA between SSc patients and HC.SScHCp-valueAge adjusted p-valueSMANMean ± SDNMean ± SDCaliber (mm)285.75 ± 0.62286.45 ± 0.60<0.00010.0002PSV (cm/sec)28137.50 ± 34.5028135.26 ± 33.810.80750.7297RV (cm/sec)287.25 ± 6.372818.52 ± 6.16<0.0001<0.0001EDV (cm/sec)2816.34 ± 7.032812.64 ± 5.460.03210.0650mV (cm/sec)2838.03 ± 13.902828.32 ±9.250.00350.0150Blood-flow (cm/sec)281073.1 ± 831.1628913.36 ± 272.870.34090.4781PI283.33 ± 0.75284.53 ± 1.03<0.00010.0002RI280.88 ± 0.04280.91 ± 0.030.00340.0141IMACaliber (mm)262.71 ± 0.47242.79 ± 0.370.48720.5385PSV (cm/sec)2372.27 ± 27.232393.81 ± 25.730.00840.0044RV (cm/sec)232.69 ± 6.102317.06 ± 5.75<0.0001<0.0001EDV (cm/sec)237.87 ± 2.01237.95 ± 2.100.89210.9250mV (cm/sec)2317.83 ± 5.332314.75 ± 5.080.05140.3938Blood-flow (cm/sec)23106.70 ± 47.992084.00 ± 30.130.06760.3056PI233.54 ± 0.95236.08 ± 1.53<0.0001<0.0001RI230.88 ± 0.04230.91 ± 0.030.01320.0205SMA=superior mesentheric artery, IMA=inferior mesentheric artery, PSV=Peak Systolic Velocity, RV=Reverse Velocity, EDV=End-Diastolic Velocity, mV=Mean Velocity, PI=Pulsatility Index, RI=Resistive Index.Conclusion:this preliminary study shows, for the first time, the presence of a significant reduction of RV, PI and RI in the intestinal arteries of SSc patients when compared to HC. These data show an increased stiffness of the gastrointestinal arterial wall, in agreement with the typical SSc vasculopathy. A larger cohort is needed to confirm the results and explore the possible relationship with other clinical features of the disease.References:[1]Sjogren, RW.Gastrointestinal features of scleroderma. Curr Opin Rheumatol 1996;8:569-75.Disclosure of Interests:None declared
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Graves, J. S., B. E. Dunn, and S. C. Brown. "Embryonic chick allantois: functional isolation and development of sodium transport." American Journal of Physiology-Cell Physiology 251, no. 5 (November 1, 1986): C787—C794. http://dx.doi.org/10.1152/ajpcell.1986.251.5.c787.
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By removing the shell membranes from the chorioallantoic membrane, the chorion is damaged, as visualized by electron microscopy, and rendered permeable, as evidenced by penetration of horseradish peroxidase and increased inhibition of the allantoic Na+-K+ pump by ouabain applied on the chorionic side. The short-circuit current (SCC) of this functionally isolated allantoic epithelium is augmented by nystatin, a channel-forming ionophore, when applied to the mucosal surface. Electrical parameters were determined for three age groups between 12 and 19 days of incubation. The SCC approximately doubled from the youngest (12-13 days) to the oldest (18-19 days) groups, whereas the transepithelial resistance (Re) of 700-900 omega X cm2 remained the same. Amiloride, an inhibitor of apical Na+ uptake, inhibited 98-100% of the SCC at 10(-4) M in both 15-16 and 18-19 day epithelia. In the 12- to 13-day preparation 20-25% of the SCC was insensitive to 10(-3) M amiloride. The Ki's for amiloride were similar in all preparations, at about 5 X 10(-7) M. Determination of the Hill coefficients for inhibition revealed a lower value (0.75 +/- 0.03) for the 12-13 day preparation compared with the two older preparations with coefficients not significantly different from unity. Replacing Na+ in the bathing solutions abolished the SCC of 18-19 day epithelia, whereas about 15% of the SCC remained at 12-13 days. Thus, during development, the SCC of the allantoic epithelium increases in magnitude and becomes increasingly (to 100%) amiloride-sensitive and Na+-dependent.
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Orbai, A. M., M. E. Husni, D. D. Gladman, B. Parikh, X. Meng, C. Gaillez, and P. J. Mease. "POS1050 SECUKINUMAB LEADS TO IMPROVEMENT ACROSS PSORIATIC ARTHRITIS MANIFESTATIONS OVER 2 YEARS REGARDLESS OF PREVIOUS EXPOSURE TO A TNF INHIBITOR: A POST HOC ANALYSIS OF FUTURE 5." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 802–3. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1862.
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Background:The goal of treating psoriatic arthritis (PsA) is to achieve very low disease activity or remission across disease manifestations. In the phase 3 FUTURE 5 study (NCT02404350), patients receiving secukinumab (SEC) demonstrated sustained clinical improvements across PsA manifestations through Week 104.1 However, the effect of previous tumor necrosis factor inhibitor (TNFi) exposure on achievement of remission across PsA manifestations was not explored.Objectives:To report exploratory efficacy analyses of SEC at Week 104 on stringent endpoints across PsA manifestations in patients who were TNFi naive or inadequate responders (TNF-IR).Methods:Patient data from FUTURE 5 were stratified by previous TNFi exposure and analyzed by treatment arm. At Week 104, patients received SEC 300 or 150 mg with subcutaneous loading dose (LD), SEC 150 mg without LD, or had received placebo up to Week 16 and were switched to SEC 300 or 150 mg between Weeks 16 or 24 based on tender and swollen joint count response. Patients with suboptimal clinical response to SEC 150 mg could escalate to SEC 300 mg after Week 52 per investigator judgment.2 Exploratory efficacy analyses at Week 104 included resolution of TJC/SJC (0 tender/swollen joints), resolution of enthesitis and dactylitis, 75% improvement in the modified Nail Psoriasis Severity index (mNAPSI75), 100% improvement in the Psoriasis Area and Severity Index (PASI100), very low disease activity (VLDA), and Disease Activity in Psoriatic Arthritis (DAPSA) remission. Descriptive statistics are provided for each endpoint using an observed-case approach.Results:Regardless of previous TNFi exposure, SEC-treated patients achieved several stringent endpoints across PsA domains, including TJC/SJC resolution, resolution of dactylitis/enthesitis, mNAPSI75, and PASI100 at Week 104 (Table 1). TNFi-naive patients generally experienced greater improvements than TNF-IR patients (Table 1 above). Similar trends were observed for achievement of VLDA and DAPSA remission at Week 104 (Figure 1).Conclusion:SEC treatment resulted in sustained achievement of stringent endpoints across key PsA manifestations through Week 104 in both TNFi-naive and TNF-IR patients, with generally greater clinical responses among TNFi-naive patients.References:[1]Mease P, et al. Ann Rheum Dis. 2018;77:890-897.[2]Mease P, et al. Arthritis Rheumatol. 2019;71:(suppl 10) [abstract 1554].Table 1.Achievement of Key Outcomes Across PsA Manifestations at Week 104 Among TNF-IR and TNFi-Naive Patients Treated With SECSEC 300 mgSEC 150 mgaSEC 150 mg No LoadbPBO–SEC 300 mgPBO–SEC 150 mgcOutcomes, n/M (%)TNFi-naiven=154TNF-IRn=68TNFi-naiven=153TNF-IRn=67TNFi-naiven=157TNF-IRn=65TNFi-naiven=109TNF-IRn=44TNFi-naiven=114TNF-IRn=39TJC/SJC resolution51/140 (36.4)19/51 (37.3)46/136 (33.8)11/46 (23.9)53/125 (42.4)14/43 (32.6)40/90 (44.4)11/31 (35.5)32/96 (33.3)10/28 (35.7)Resolution of dactylitis42/48 (87.5)11/16 (68.8)37/43 (86.0)16/19 (84.2)56/62 (90.3)11/13 (84.6)35/41 (85.4)5/7 (71.4)30/33 (90.9)10/12 (83.3)Resolution of enthesitis70/88 (79.5)22/30 (73.3)70/85 (82.4)24/32 (75.0)50/69 (72.5)16/26 (61.5)37/50 (74.0)12/17 (70.6)39/56 (69.6)14/20 (70.0)mNAPSI7561/73 (83.6)15/26 (57.7)66/76 (86.8)16/23 (69.6)61/80 (76.3)13/18 (72.2)42/51 (82.4)13/17 (76.5)34/64 (53.1)7/14(50.0)PASI10034/68 (50.0)14/29 (48.3)41/85 (48.2)5/19(26.3)33/73 (45.2)4/18(22.2)23/45 (51.1)9/18(50.0)19/46 (41.3)6/13(46.2)IR, inadequate responder; M, number of evaluable patients; mNAPSI, modified Nail Psoriasis Severity Index; PASI, Psoriasis Area and Severity Index; PBO, placebo; SEC, secukinumab; TJC/SJC resolution, 0 tender/swollen joints; TNFi, tumor necrosis factor inhibitor.a Includes 53 TNFi-naive and 23 TNF-IR patients with dose escalation.b Includes 58 TNFi-naive and 19 TNF-IR patients with dose escalation.c Includes 40 TNFi-naive and 12 TNF-IR patients with dose escalation.Figure 1.Acknowledgements:This study was funded by Novartis Pharma AG. The authors thank Prasanthi Mandalay, PhD, of ArticulateScience LLC, for providing medical writing support/editorial support, which was funded by Novartis Pharmaceuticals Corporation, East Hanover, NJ, in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3).Disclosure of Interests:Ana-Maria Orbai Consultant of: Janssen, Eli Lilly, Novartis, Pfizer, and UCB, Grant/research support from: AbbVie, Celgene, Horizon, Janssen, Eli Lilly, and Novartis, M Elaine Husni Consultant of: AbbVie, Amgen, Gilead, Janssen, Eli Lilly, Novartis, Pfizer, Regeneron, and UCB, Grant/research support from: Pfizer, Dafna D Gladman Consultant of: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Galapagos, Gilead, Janssen, Eli Lilly, Novartis, Pfizer, and UCB, Grant/research support from: AbbVie, Amgen, Celgene, Eli Lilly, Novartis, Pfizer, and UCB, Bhumik Parikh Employee of: Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, Xiangyi Meng Employee of: Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, Corine Gaillez Employee of: Novartis Pharma AG, Basel, Switzerland, Philip J Mease Speakers bureau: AbbVie, Amgen, Janssen, Eli Lilly, Novartis, Pfizer, and UCB, Consultant of: AbbVie, Amgen, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Galapagos, Gilead, GlaxoSmithKline, Janssen, Eli Lilly, Novartis, Pfizer, Sun Pharma, and UCB, Grant/research support from: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Gilead, Janssen, Eli Lilly, Novartis, Pfizer, Sun Pharma, and UCB.
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Singh, P. K., Rohit K. Shrivastava, and K. G. Sinha. "Study And Evaluation of Injection Timing of CIDI Engine Injection Pump Using Alternate Fuel i.e Biodiesel Fuel." SAMRIDDHI : A Journal of Physical Sciences, Engineering and Technology 8, no. 01 (June 25, 2016): 11–19. http://dx.doi.org/10.18090/samriddhi.v8i1.11407.
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In this investigation an experimental study of the effects of FIP injection timing on Specific Fuel Consumption(SFC), Brake Thermal Efficiency(BTE), Engine Exhaust Gas Temperature(EEGT), CO, HC, NOX and Smoke of “Kirloskar- 6R1080TA, 6-CylinderInline, Direct Injection, Turbocharged Intercooled, 191 hp Diesel Engine” has been conducted. Injection Timing retardation method has been utilised to reduce SFC, EEGT, CO, HC, NOX, Smoke and increase BTE of Kirloskar-6R1080TA Diesel Engine. The Kirloskar 6R1080TA engine has been tested for six different injection timings (23°, 21°, 20°, 19°, 18° and 17° CA BTC) at same engine speeds and load conditions. The SFC,EEGT, CO, HC, NOX and Smoke of engine are approximately higher and BTE lower for injection timings at 23°, 21°, 20°, 18° and 17° CA BTC than 19° CA BTC at same speed and load. The results are showing that SFC,EEGT,CO,HC,NOX and Smoke are approximately reduces and BTE increases by reducing injection timing from 23° CA BTC to 19° CA BTC. Optimum FIP injection timing for Kirloskar 6R1080TA engine has been achieved at 19° CA BTC.
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Yamada, Milton Macoto, Fábio Gelape Faleiro, Uilson Vanderlei Lopes, Acassi Batista Flores, José Luis Pires, and Gilson Roberto Pires Melo. "Genetic divergence in cocoa progenies for backcrossing program to witches' broom disease resistance." Revista Ceres 57, no. 1 (February 2010): 73–78. http://dx.doi.org/10.1590/s0034-737x2010000100013.
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Backcrossing has been little used in cacao breeding, particularly due to the long time required to transfer genes and recover the genetic background of the recurrent parent. The objective of this study was to select individuals, resulting from the backcross CEPEC-42 x SIC-19, genetically related to the recurrent parent SIC-19 by using RAPD molecular markers, among those with resistance to witches' broom. Of the 31 plants that clustered with SIC-19, 18 from the replanted material remained free of the disease in the field, with good vegetative aspect and, therefore can be used for backcross to reach the desired objective.
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Becker-Guedes, F., Y. Sahai, P. R. Fagundes, E. S. Espinoza, V. G. Pillat, W. L. C. Lima, Su Basu, et al. "The ionospheric response in the Brazilian sector during the super geomagnetic storm on 20 November 2003." Annales Geophysicae 25, no. 4 (May 8, 2007): 863–73. http://dx.doi.org/10.5194/angeo-25-863-2007.
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Abstract. A very intense geomagnetic storm (superstorm) began with storm sudden commencement (SSC) at 08:03 UT on 20 November 2003, as a result of the coronal mass ejection (CME) by sunspot 484 hurled into space on 18 November 2003. The geomagnetic storm attained |Dst|max=472 nT at 20:00 UT (20 November). In this paper we present the simultaneous ionospheric sounding observations, using the Canadian Advanced Digital Ionosondes (CADIs), carried out from Palmas (PAL; 10.2° S, 48.2° W; dip latitude 5.5° S; a near equatorial station) and São José dos Campos (SJC; 23.2° S, 45.9° W; dip latitude 17.6° S; station located under the crest of equatorial ionospheric anomaly), Brazil. In addition, total electron content (TEC) measurements from several GPS receiving stations in the Brazilian sector during this storm are presented. The simultaneous ionospheric sounding observations carried out at SJC and PAL, and TEC observations on 3 consecutive days viz., 19 November (quiet), 20 November (disturbed) and 21 November (recovery phase) are presented. Salient features from the ionospheric observations in the Brazilian sector during the superstorm are discussed. The difference in the observed ionospheric response at the two stations (PAL and SJC) is considerable. This is not surprising given that PAL is close to the magnetic equator and SJC is near the crest of the equatorial ionospheric anomaly (EIA). It should be pointed out that soon after the SSC (about 4 h later), the F-region critical frequency (foF2), the F-region peak height (hpF2), and variations of virtual heights at different frequencies (iso-frequency plots) all show wavelike oscillations of the F-region during daytime at both the ionospheric sounding stations. Unusual rapid uplifting of F-region at PAL was observed during both the main and recovery phases of the storm.
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Raman, R. S., Vijaykumar Bhagwan Barge, Darivenula Anil Kumar, Himanshu Dandu, R. Rakesh Kartha, Varun Bafna, Vishaly T. Aravinda, and Thummala C. Raghuram. "A Phase II Safety and Efficacy Study on Prognosis of Moderate Pneumonia in Coronavirus Disease 2019 Patients With Regular Intravenous Immunoglobulin Therapy." Journal of Infectious Diseases 223, no. 9 (February 15, 2021): 1538–43. http://dx.doi.org/10.1093/infdis/jiab098.
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Abstract Background Currently, there is no specific drug for the treatment of coronavirus disease 2019 (COVID-19). Therapeutic benefits of intravenous immunoglobulin (IVIG) have been demonstrated in wide range of diseases. The present study is conducted to evaluate the safety and efficacy of IVIG in the treatment of COVID-19 patients with moderate pneumonia. Methods An open-label, multicenter, comparative, randomized study was conducted on COVID-19 patients with moderate pneumonia. One hundred eligible patients were randomized in 1:1 ratio either to receive IVIG + standard of care (SOC) or SOC. Results Duration of hospital stay was significantly shorter in the IVIG group compared with that of SOC alone (7.7 vs 17.5 days). Duration for normalization of body temperature, oxygen saturation, and mechanical ventilation were significantly shorter in IVIG compared with SOC. Percentages of patients on mechanical ventilation in 2 groups were not significantly different (24% vs 38%). Median time to reverse-transcription polymerase chain reaction negativity was significantly shorter with IVIG than SOC (7 vs 18 days). There were only mild to moderate adverse events in both groups except for 1 patient (2%), who died in SOC. Conclusions Intravenous immunoglobulin was safe and efficacious as an adjuvant with other antiviral drugs in the treatment of COVID-19.
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Anigilaje, Emmanuel Ademola, and Ishola Ibraheem. "Acute kidney injury in children with nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: 2016 to 2021." AIMS Medical Science 9, no. 1 (2022): 18–31. http://dx.doi.org/10.3934/medsci.2022004.
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<abstract><sec> <title>Background</title> <p>Information regarding acute kidney injury (AKI) is scarce among Nigerian children with nephrotic syndrome (NS). This study describes the prevalence, risk factors and outcomes of AKI among children with NS at the University of Abuja Teaching Hospital (UATH), Abuja, Nigeria.</p> </sec><sec> <title>Materials and methods</title> <p>This is a review of children with NS, from January 2016 to October 2021 at the UATH. AKI was classified by the paediatric RIFLE criteria.</p> </sec><sec> <title>Results</title> <p>Of the 75 children with NS, aged 13 months to 18 years, with a mean age of 10 ± 18 years, and majorly (64, 85.3%) males. AKI occurred in 19 of 75 (25.3%) subjects comprising Failure in 15 (78.9%), Injury in 3 (15.8%) and Risk in 1 (5.3%). Regarding risk factors of AKI at hospital admission; subjects with no sepsis were at reduced odds of AKI (OR = 0.01, 95% CI = 0.02–0.06, p < 0.001); and the risk of AKI was reduced among subjects without gross haematuria (OR = 0.07, 95% CI = 0.01–0.66, p = 0.004). The likelihood of AKI increased in the presence of peritonitis (OR = 7.91, 95% CI = 2.15–29.15, p < 0.001) and urinary tract infections (UTIs) (OR = 2.55, 95% CI = 1.39–4.66, p < 0.001). Subjects with historical exposure to nephrotoxic medications (NTM) were also at risk of AKI (OR = 1.79, 95% CI = 1.13–2.84, p = 0.001). The only 2 deaths (2.6%) observed in the short term was among those with AKI (2/19, 10.5%) but full renal recovery occurred in the majority (16/19, 84.2%).</p> </sec><sec> <title>Conclusions</title> <p>AKI is common in our children with NS. Sepsis, gross haematuria, peritonitis, UTIs and NTM were its identified risk factors. It is prudent to have a suspicion of AKI among children with NS with these risk factors in our setting.</p> </sec></abstract>
Dissertations / Theses on the topic "Séc. 18-19"
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Morais, Maria Antonieta Lopes Vilão Vaz de. "Pintura nos séculos XVIII e XIX na galeria de retratos dos benfeitores da Santa Casa da Misericórdia do Porto." Dissertação, Porto : [Edição do Autor], 2001. http://aleph.letras.up.pt/F?func=find-b&find_code=SYS&request=000109553.
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Este estudo baseou-se numa investigação sobre a pintura de retrato da colecção da Santa Casa da Misericórdia, de 1649 a 1867. O estudo da proveniência do retrato e de todos aqueles que por detrás deste estiveram ligados os artistas, os encomendadores e os próprios retratos, permitiu-nos a autenticação do retrato, baseado na documentação do Arquivo da Santa Casa, e o estudo dos pintores. Um estudo dos pintores. Um estudo sobre os benfeitores retratados levou-nos a compreender a importância de uma Instituição como a Santa Casa da Misericórdia e as pessoas que contribuiram para o seu desenvolvimento.
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Morais, Maria Antonieta Lopes Vilão Vaz de. "Pintura nos séculos XVIII e XIX na galeria de retratos dos benfeitores da Santa Casa da Misericórdia do Porto." Master's thesis, Porto : [Edição do Autor], 2001. http://hdl.handle.net/10216/18490.
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Este estudo baseou-se numa investigação sobre a pintura de retrato da colecção da Santa Casa da Misericórdia, de 1649 a 1867. O estudo da proveniência do retrato e de todos aqueles que por detrás deste estiveram ligados os artistas, os encomendadores e os próprios retratos, permitiu-nos a autenticação do retrato, baseado na documentação do Arquivo da Santa Casa, e o estudo dos pintores. Um estudo dos pintores. Um estudo sobre os benfeitores retratados levou-nos a compreender a importância de uma Instituição como a Santa Casa da Misericórdia e as pessoas que contribuiram para o seu desenvolvimento.
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Rosa, Mélanie Elisabeth Ferreira. "As árvores ornamentais introduzidas nos jardins de Lisboa: uma perspectiva histórica (séc. 18-19)." Master's thesis, ISA/UTL, 2013. http://hdl.handle.net/10400.5/5661.
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Mestrado em Arquitectura Paisagista - Instituto Superior de AgronomiaThe main objective of this thesis is to study the composition three Lisbon’s gardens across time, during the eighteenth and nineteenth centuries, in order to illustrate the botanical diversity of the gardens at the time of their origins and the possible timing of the entry of exotic plants in Lisbon. This information beyond its historical value may also contribute to the restoration projects of historic gardens, making known, which tree species used at time. To address this issue, three gardens have been selected – Ajuda Botanic Garden, Tapada das Necessidades and Jardim da Estrela - these gardens created, during the mentioned historical period, played a significant role in the enrichment of its botanical collections. For each case, will be made a research of historical documents regarding to the composition of the garden (catalogs and inventories), the arboreal current species and a synthesis of all this information collected. Finally, there will be a comparative analysis of all this data so that it is possible to obtain records on the composition of these gardens during the eighteenth and nineteenth centuries, as well as presenting a range of approximate time concerning the introduction of exotic species in the gardens under study
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Carvalho, José Paulo Torres Vaz de. "Pensamento polifónico na didáctica de guitarra, do século XVII ao século XX." Doctoral thesis, Universidade de Aveiro, 2004. http://hdl.handle.net/10773/17976.
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Doutoramento em MúsicaA guitarra, na sua capacidade polifónica, situa-se na linha de fronteira entre os instrumentos de tecla e os de arco. O presente estudo debruça-se sobre os diversos modos de explorar a sua capacidade de texturação e realização polifónica, à luz de um conjunto de obras didácticas dedicadas ao acompanhamento e à técnica solística, balizados entre os séculos XVII e XX.
The guitar, with its poliphonic capacity, lies between the world of keyboard instruments and string instruments. The present study will show how to explore these two dimensions according to didactic works dedicated to accompaniment and solistic techniques, between the seventeenth and twentieth centuries.
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Borges, Ana Margarida de Almeida. "Pedro José da Fonseca e a sua obra lexicográfica." Doctoral thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/3933.
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Doutoramento em LinguísticaEste trabalho tem por objecto de estudo a obra de Pedro José da Fonseca, precipuamente a obra lexicográfica - Pawum Lexicon (1762), Diccionario Portuguez, e Latino (1771), Diccionario abbreviado da fabula (1779) e o Diccionario da Lingoa Portugueza (1 793). Necessidade premente num contexto de remodelação de todo o panorama do ensino em Portugal e de modificação das estruturas e hábitos da sociedade portuguesa, a composição destas obras iria corresponder ao consumo escolar e às solicitações da prática pedagógica almejada pela reforma pombalina. No plano geral da descrição crítica destes dicionários, atribui-se especial relevância, no cotejamento com as fontes, ao aperfeiçoamento da técnica lexicográfica. Propõe-se: o esboço da biografia do autor e um breve enquadramento históricocultural da 2" metade do século XVIII; o estudo da obra literária de Pedro da Fonseca, examinando o seu pensamento linguístico; análise da técnica de composição dicionan'stica a nível macro e microestrutural e, por fim, uma reflexão em torno do "corpus" lexical português nos dicionários de Fonseca.
This study is focused on Pedro José da Fonseca's work, particularly on his lexicographic work - Parvum Lexicon (1 762), Diccionario Portuguez, e Latino (1 77 1 ) , Diccionario abbreviado da fabula (1 779) and t he Diccionario da Lingoa Portugueza (I 793). In the context of educational reforms and changing of the structure and customs of the Portuguese society, the need to compose urgently new works that might answer the needs of Pombal's aims in relation to education and that could at the same time fulfil the capacities of school usage, emerges. In the general and critical description of these dictionaries, it is stressed, through the collation with sources, the improvement of the techniques used in the making of dictionaries. It is proposed: the outline of author's biography and the description of historical and cultural context in the second half of eighteenth century; the study of the Fonseca's literary work, analysing his linguistic ideas; analysis of lexicographic technique in terms of macrostructure and microstructure, and, at last, a reflection around the Portuguese lexical corpus in Fonseca's dictionaries.
FCT
FSE
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Santos, Danilo de Jesus da Veiga dos. "O Cabo-verdiano através dos olhos de forasteiros: representações nos textos portugueses, 1784-1844." Master's thesis, 2011. http://hdl.handle.net/10451/4152.
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Tese de mestrado, História de África, Universidade de Lisboa, Faculdade de Letras, 2011Ao ler os textos portugueses dos finais do século XVIII e a primeira metade do século XIX deparase com uma certa depreciação e africanização do homem cabo-verdiano. As formas de sociabilidade dos cabo-verdianos eram reprovadas por estes serem demasiados próximo dos “negros africanos”. Estas representações continuam a ser menos conhecidas tanto no domínio da História como nos outros campos do saber. Ora, o presente trabalho debruça-se sobre a imagem do homem caboverdiano construída, pensada, e dada a ler nos textos portugueses produzidos pelos forasteiros no período entre 1784 e 1844. O corpo textual que sustenta este estudo foi produzido a partir do contacto com as ilhas e os seus habitantes ou, muitas vezes, a partir de informações de terceiros, por alguém cujos padrões mentais e culturais pertenciam à outra realidade. Da longa relação dos portugueses/europeus com os africanos sob a soberania portuguesa no espaço cabo-verdiano desenvolveu-se uma cultura nova e um homem novo – uma nova sociedade, que por um lado reflecte o fracasso português na assimilação dos cabo-verdianos e por outro mostra a capacidade de, num espaço novo, através do processo de mestiçagem, que foi quase um fenómeno natural nas ilhas de Cabo Verde, surgir algo novo, com contornos próprios, que se pode caracterizar de caboverdiano
Abstract: By reading late XVIII and first half of XIX centuries portuguese texts we find some depreciation and africanization of the Cape Verdean man. The forms of sociability of the Cape Verdeans were disapproved for being these very similar to the “black africans”. These representations are still not widely known in History and other areas of knowledge. So, the present dissertation focus on the image of the Cape Verdean man built, thought and readable in these Portuguese texts, produced by foreigners/outsiders in the period between 1784 and 1844. The accounts which sustain this study, the present dissertation was also built from contact with the Cape Verdean archipelago and its people, and sometimes counts with informations exchanged with persons which cultural and mental patterns fitting other realities. The long relationship between Portuguese/Europeans and Africans, under the portuguese sovereignty, in the Cape Verdean territory, gave birth to a new culture and a new man - a new society that expresses not only the Portuguese failure in the assimilation of the Cape Verdeans but also expresses the capacity to make something new happen. Something that, through the métissage process, in a new place, with its own aspects, can be named as Cape Verdean.
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Leandro, Joana Maria Fernandes. "Os expostos da Póvoa de Varzim: 1792-1836." Master's thesis, 2008. http://hdl.handle.net/10451/1729.
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Tese de mestrado em História Regional e Local apresentada à Faculdade de Letras da Universidade de Lisboa, 2008A dissertação Os expostos na Póvoa de Varzim (1792-1836) revela a problemática do abandono de crianças, na vila piscatória da Póvoa de Varzim, entre finais do século XVIII e inícios do século XIX. A Roda dos Expostos foi criada e institucionalizada em Portugal e por toda a Europa devido ao elevado número de crianças abandonadas. Este estudo mostra uma pequena parte desse fenómeno generalizado, analisando os registos de entrada e, através deles, uma envolvência social mais vasta e complexa. Referimo-nos a uma época marcada pela carestia de vida, por uma forte religiosidade, por muitos casos de infanticídio e elevadas taxas de mortalidade infantil. Assim, a Roda dos Expostos foi a solução procurada por muitos cidadãos.
The dissertation Os expostos na Póvoa de Varzim (1792-1836) reveals the problematics of children's abandonment, in the piscatorial town of Póvoa de Varzim, between late XVIIIth century and the beginnings of the XIXth century. The foundling homes were created and institutionalized in Portugal and throughout Europe, due to the grate numbers of exposed children. This study shows a small part of this generalized phenomenon, analysing the registries of entrance and, through them, a vaster and more complex social ambience. We refer to a time of life marked by famine, by a strong religiosity, many cases of infanticide and high rates of infant mortality. Thus, the foundling homes were the solution sought by many people
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Oliveira, Daniel Carlos Siqueira de. "A paciência tudo alcança! A expansão da regra de Santa Teresa no Brasil colonial: uma perspectiva comparada." Master's thesis, 2021. http://hdl.handle.net/10451/50740.
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Magalhães, Alberto da Conceição. "A Real Fábrica das Sedas e o comércio têxtil com o Brasil: 1734-1822." Master's thesis, 2010. http://hdl.handle.net/10451/4153.
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Tese de mestrado, História dos Descobrimentos e da Expansão, Universidade de Lisboa, Faculdade de Letras, 2011Na presente dissertação estudou-se a história da Real Fábrica das Sedas e da sua relação com o Brasil. Criada em Lisboa, em 1734, sob protecção régia, por um grupo de mercadores abastados, cedo a fábrica começou a experimentar problemas de ordem técnica e financeira, em resultado de um mercado deficiente e da concorrência dos tecidos ingleses de melhor qualidade e mais baixo preço. Em 1757, a fábrica recuperaria posição no mercado nacional e ultramarino por iniciativa do Secretário de Estado do Reino e Mercês, Sebastião José de Carvalho e Melo, conde de Oeiras e futuro marquês de Pombal, devido às novas regras de gestão, designadamente: uma maior intervenção da Coroa, dependência administrativa da Junta do Comércio, promulgação de estatutos relativos às várias facetas da fábrica, tais como e, de entre outras, laboração, preparação técnica e protecção social dos empregados e suas famílias. O empreendimento acabou por funcionar como uma escola e uma corporação de ofícios. Paralelamente, ocorreu o alargamento da produção a outros sectores industriais, além dos têxteis, a contratação de artífices estrangeiros especializados, a articulação com as companhias monopolistas do comércio com o Brasil e a criação de normas creditícias para facilitar pagamentos. Deuse ainda um incentivo à plantação de amoreiras. Após a retirada do marquês de Pombal do governo, a alteração da política industrial não beneficiou a fábrica, que não soube enfrentar o incremento da concorrência inglesa nem a difusão mais acentuada do algodão no mercado. Finalmente, a retirada da família real e de parte da nobreza para o Brasil, devido às invasões francesas (1807), a abertura dos portos brasileiros (1808), a permissão de fabrico de sedas no Brasil (1808) e o tratado de comércio com a Inglaterra (1810), ditariam uma nova fase de decadência da fábrica, que culminaria com a sua venda em hasta pública, decretada pela portaria de 27 de Julho de 1835, do Ministro do Reino
Abstract: In the present dissertation, the history of the Royal Silk Factory and its relationship with Brazil was studied. Created in Lisbon, in 1734, under royal protection, by a group of wealthy merchants, the factory soon began to experience technical and 3 financial difficulties due both to a poor market and to the competition by the superior and more affordable English textiles. In 1757, the factory would recover and assert itself in the national and overseas markets by initiative of the Honorary Secretary of State of the Kingdom Sebastião José de Carvalho e Melo, Count of Oeiras and future Marquis of Pombal, due to the new management rules, namely: a larger intervention by the Crown, administrative dependence on the Chamber of Commerce, promulgation of statutes related to the various aspects of the factory, such as, labor, technical preparation and social protection of the workers and their families. The undertaking turned up serving as a school and a corporation of trades. Similarly, the production was expanded to other industrial sectors besides textiles, skilled foreign craftsmen were hired, an utterance to monopolist companies of commerce with Brazil and credit rules were enacted in order to enable payments. In addition, an incentive was given for the cultivation of mulberry trees. After the Marquis of Pombal having left the government, the changes put into industrial politics didn´t benefit the factory, which was unable to face the increasing English competition or the more accentuated diffusion of cotton in the markets. Finally, the retreat of the royal family and part of the nobility to Brazil, due to the Napoleonic invasions (1807), the opening of the Brazilian ports (1808), the authorization granted to manufacture silk in Brazil (1808) and the trade treaty with England (1810) would dictate a new stage of decadence of the factory, which would culminate with its sale in public auction, decreed by the ordinance of July 27th of 1835, by the Minister of the Kingdom.
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Lima, Péricles Pedrosa. "Homens de ciência a serviço da coroa: os intelectuais do Brasil na Academia Real de Ciências de Lisboa: 1779/1822." Master's thesis, 2009. http://hdl.handle.net/10451/514.
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Tese de mestrado, História dos Descobrimentos e da Expansão, Universidade de Lisboa, Faculdade de Letras, 2009Este trabalho procura identificar os académicos de origem brasileira que fizeram parte do quadro de sócios da Academia Real de Ciências de Lisboa a partir de sua fundação em 1779 até o ano de 1822; ano da independência do Brasil. Além de identificar quem eram esses intelectuais procura-se também descobrir a sua origem no Brasil, formação académica e ano de eleição para a Academia. A seguir apresenta-se o conjunto de suas obras em diversos campos científicos e publicadas por diversas instituições. Dentro deste universo, faz-se uma interpretação das obras que a Academia Real de Ciências de Lisboa publicou. A Europa vivia o Iluminismo, movimento das luzes e de mudança de valores, e sendo assim, procura-se também situar Portugal dentro deste movimento e a adaptação às novas ideias e valores. Na leitura das obras dos académicos brasileiros impressas pela Academia Real de Ciências de Lisboa procura-se visualizar a influência do Iluminismo e também se foram desenvolvidas em benefício do fortalecimento do Império Português ou de um movimento libertador da colónia brasileira.
This work looks for to identify the academics of Brazilian origin that had been part of the Real Academy of Sciences of Lisbon from its foundation in 1779 until the year of 1822; year of the independence of Brazil. Beyond identifying who they were these intellectual ones is also looked to discover its origin in Brazil, academic formation and year of election for the Academy. To follow the set of its workmanships in diverse fields scientific and published by diverse institutions is presented. Inside of this universe, an interpretation of the workmanships becomes that the Real Academy of Sciences of Lisbon published. The Europe lived the Illumines, movement of the lights and change of values, and being thus, it is also looked to point out Portugal of this movement inside and the adaptation to the new ideas and values. In the reading of the workmanships of the Brazilian academics printed for the Real Academy of Sciences of Lisbon are looked to visualize the influence of the Illumines and also they had been developed in benefit of the reinforcement of the Portuguese Empire or a liberating movement of the Brazilian colonial.
Books on the topic "Séc. 18-19"
1
Fauchon, Paul. Journal de marche du sergent Paul Fauchon: Kabylie, Tizi Gueniff [sic], 19 juillet 1956-18 mars 1957. Montpellier: UMR 5609 du CNRS, Université Paul-Valéry, Montpellier III, 1997.
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International Conference Media in Post-Communist Societies: Objective Information vs. Ideological Bias (2002 Minsk, Belarus). Mėdyi ŭ postkamunistychnykh hramadztvakh--ab'ektyŭnai͡a︡ infarmatsyi͡a︡ supratsʹ idėali͡a︡hichnykh skaz͡h︡ėnʹni͡a︡ŭ: Matėryi͡a︡ly miz͡h︡narodnaĭ kanfėrėntsyi, Mensk, 18-19 kastrychnika, 2002 h. = Media in post-communist societies--objective information vs. ideoligical [sic] bias : materials of the international conference, Minsk, 18-19 October, 2002. Sankt-Peterburg: Izd-vo "Azbuka", 2003.
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The main issues of Western Armeniancy's [sic] claims: International research and practical conference, Cyprus, Nicosia, April 18-19, 2008; collection of conference papers. Erevan: International Organizing Committee for the Preparation of the Western Armenian National Congress, 2009., 2009.
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United States. Congress. Senate. Committee on Labor and Human Resources. Excellence in Mathematics, Science, and Engineering Act of 1990: Hearings before the3 [sic] Committee on Labor and Human Resources and the Subcommittee on Labor, Health and Human Services, Education, and Related Agencies of the Committee on Appropriations, United States Senate, One Hundred First Congress, second session, on S. 2114 ... April 19, Washington, DC; May 14, Boston, MA; May 18, Washington, DC, and June 9, 1990, Portland, OR. Washington: U.S. G.P.O, 1990.
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"Baron." Baron: Soc Rel Hist (Vols 1-18 & Index) 19 Vol Set. Columbia University Press, 1992.
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J, Howard Andrew, Macklin Mark G, and Passmore David G, eds. Alluvial archaeology in Europe: Proceedings of the Alluvial Archaeology of North-West Europe and Mediteranian [sic], 18-19 December 2000, Leeds, UK. Lisse: A.A. Balkema, 2003.
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R, Weddell J., and British Grassland Society, eds. Seeds of progress: Proceedings of the BGS/BSPB/NIAB/SAC conference held at the Moat House Hotel,Nottingham on 18-19 February 1997. [Reading?]: British Grassland Society, 1997.
Find full textBook chapters on the topic "Séc. 18-19"
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"Reihe 089, Jg. 1878 Kirchenfreund.Kalender [sic!]." In Deutsch-amerikanische Kalender des 18. und 19. Jahrhunderts / German-American Almanacs of the 18th and 19th Centuries, edited by York-Gothart Mix. Berlin, Boston: DE GRUYTER, 2011. http://dx.doi.org/10.1515/9783110253535.1378.
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"Reihe 091, Jg. 1879 FamilienKalender [sic!]." In Deutsch-amerikanische Kalender des 18. und 19. Jahrhunderts / German-American Almanacs of the 18th and 19th Centuries, edited by York-Gothart Mix. Berlin, Boston: DE GRUYTER, 2011. http://dx.doi.org/10.1515/9783110253535.1397.
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Taber, Douglass. "Intermolecular and Intramolecular Diels-Alder Reactions: (-)-Oseltamivir (Fukuyama), Platensimycin (Yamamoto) and 11,12-Diacetoxydrimane (Jacobsen)." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0078.
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Powerful methods for catalytic, enantioselective intermolecular Diels-Alder reactions have been developed. Ben L. Feringa and Gerard Roelfes of the University of Groningen have shown (Organic Lett. 2007, 9, 3647) that a catalyst prepared by combining salmon testes DNA with a Cu complex directed the absolute sense of the addition of 1 to cyclopentadiene 2 . Mukund P. Sibi of North Dakota State University has reported (J. Am. Chem. Soc . 2007, 129 , 395) related work with achiral pyrazolidinone dienophiles and chiral Cu catalysts. Tohru Fukuyama of the University of Tokyo found (Angew. Chem. Int. Ed . 2007, 46, 5734) that the MacMillan catalyst 5 was effective at mediating the addition of acrolein 4 to the pyridine-derived diene 3, enabling an enantioselective synthesis of the prominent antiviral (-)-oseltamivir (tamiflu) 7. Hisashi Yamamoto of the University of Chicago has demonstrated (J. Am. Chem. Soc . 2007, 129, 9534 and 9536) that the novel catalyst 10 effected addition of methyl acrylate 9 to the diene 8, leading to an elegant enantioselective synthesis of the tetracycle 12, the key intermediate in the Nicolaou synthesis of platensimycin. New illustrations of the power of the intramolecular Diels-Alder reaction have been put forward. Demonstrating the influence of a single subsituent on the tether, William R. Roush of Scripps/Florida found (Organic Lett . 2007, 9, 2243) that cyclization of 13 led to the diastereomer 14, complementary to the result observed with an acyclic triene. Ryo Shintani and Tamio Hayashi of Kyoto University have extended (Angew. Chem. Int. Ed . 2007, 46, 7277) their studies of chiral diene-based Rh catalysts to the enantioselective cyclization of alkynyl dienes such as 16. Jonathan W. Burton of the University of Oxford and Andrew B. Holmes of the University of Melbourne employed (Chem. Commun . 2007, 3954) the MacMillan catalyst 5 for the cyclization of 18 to 19. It is impressive that ent- 5 catalyzed the cyclization of 18 cleanly into the diastereomer of 19 in which both of the newly-created stereogenic centers were inverted.
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Lambert, Tristan H. "Construction of Single Stereocenters." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0031.
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Haifeng Du at the Chinese Academy of Sciences reported (J. Am. Chem. Soc. 2013, 135, 6810) the borane-catalyzed asymmetric hydrogenation of imine 1 to 2 using the diene 3 as a chiral ligand for boron. A single-enzyme cascade for the reductive transamination of acetophenone 4 with amine 5 to produce enantiopure sec-phenethylamine 6 was developed (Chem. Commun. 2013, 49, 161) by Per Berglund at the KTH Royal Institute of Technology in Sweden. A group at Boehringer Ingelheim in Ridgefield, Connecticut, led by Jonathan T. Reeves, disclosed (J. Am. Chem. Soc. 2013, 135, 5565) a procedure for the addition of DMF anion to N-sulfinyl imine 7 to furnish tert-leucine amide 8 with high diastereoselectivity. The tertiary carbinamine 10 was synthesized (Org. Lett. 2013, 15, 34) via the carbolithiation/rearrangement of vinylurea 9 as reported by Jonathan Clayden at the University of Manchester. Gregory C. Fu at Caltech reported (Angew. Chem. Int. Ed. 2013, 52, 2525) that the chiral phosphine 12 catalyzed the enantioselective addition of trifluoroacetamide to allene 11 to produce γ-amino ester 13 in enantioenriched form. Adeline Vallribera at the Autonomous University of Barcelona found (Org. Lett. 2013, 15, 1448) that a europium pybox complex effected the highly enantioselective α-amination of β-ketoester 14 to generate 15 on the way to the Parkinson’s disease co-drug L-carbidopa. Hisashi Yamamoto at the University of Chicago and Chubu University reported (J. Am. Chem. Soc. 2013, 135, 3411) that a halfnium(IV) complex of the bishydroxamic acid 17 catalyzed the enantioselective epoxidation of the tertiary homoallylic alcohol 16 to 18. The rearrangement of the allylic carbonate 19 to produce allyl ether 21 with high ee under iridium catalysis in the presence of ligand 20 was disclosed (Org. Lett. 2013, 15, 512) by Hyunsoo Han at the University of Texas, San Antonio. The asymmetric vinylogous aldol reaction of 3-methyl-2-cyclohexen-1-one 22 and α-keto ester 23 to furnish tertiary carbinol 25 using the bifunctional catalyst 24 was developed (Org. Lett. 2013, 15, 220) by Paolo Melchiorre at ICREA and ICIQ in Spain.
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Taber, Douglass F. "Stereoselective C-O Ring Construction: The Jamison Synthesis of (-)-Gloeosporone." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0047.
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Arene diazonium salts are effective precursors for the Heck reaction. Sandro Cacchi of the Università degli Studi “La Sapienza,” Roma, observed (Synlett 2009, 1277) that the diazonium salt generated in situ from 1 coupled with 2 to deliver the butenolide 3. Daniel J. Canney of Temple University established (Tetrahedron Lett. 2009, 50, 5914) conditions for the homologation of an alkenyl ester such as 4 to the homologated lactone 5. Tsutomu Katsuki of Kyushu University established (J. Am. Chem. Soc. 2009, 131, 14218) that Ir-mediated C-H insertion converted 6 into 8 with high diastereo- and enantiocontrol. Thomas J. J. Müller of the Heinrich-Heine-Universität, Düsseldorf, optimized ( Adv. Synth. Cat. 2009, 351, 2921) the Rh-mediated enantioselective cycloisomerization of 9 to 10. Santosh J. Gharpure of the Indian Institute of Technology, Madras, showed (Organic Lett. 2009, 11, 5466) that the intramolecular cyclopropanation of 11 proceeded with high diasterocontrol. Reduction of the intermediate cyclopropane then delivered the cyclic ether 12. Brian L. Pagenkopf of the University of Western Ontario optimized (Organic Lett. 2009, 11, 5614) the diastereoselective Co-catalyzed oxidative cyclization of 13 to 14. Mark C. Bagley and Andrew E. Graham of Cardiff University found (Tetrahedron Lett. 2009, 50, 6823) that microwave heating promoted the selective BaMnO4 oxidation of 1,3-, 1,4-, and 1,5-diols such as 15 to the corresponding lactones. David W. Lupton of Monash University developed (J. Am. Chem. Soc. 2009, 131, 14176) the remarkable cyclization of 17 to 19, catalyzed by the carbene precursor 18. Hirokazu Urabe of the Tokyo Institute of Technology showed (J. Am. Chem. Soc. 2009, 131, 3166) that the unusual Rh-catalyzed cyclization of an alkynyl sulfone 20 proceeded with substantial diastereocontrol, delivering the cyclic ether 21 as the major product. Jeffrey S. Johnson of the University of North Carolina established (J. Am. Chem. Soc. 2009, 131, 14202) that Sc(OTf)3 was a particularly efficient catalyst for the opening of 22 with 23 and then reclosure, leading to 24. Steven D. R. Christie and Gareth J. Pritchard of Loughborough University (Chem. Commun. 2009, 7339) and Michael A. Kerr of the University of Western Ontario (J. Org. Chem. 2009, 74, 8414) investigated related condensations.
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"Reihe 113, Jg. 1878 Der Stadt-und [sic!] Land-Bote." In Deutsch-amerikanische Kalender des 18. und 19. Jahrhunderts / German-American Almanacs of the 18th and 19th Centuries, edited by York-Gothart Mix. Berlin, Boston: DE GRUYTER, 2011. http://dx.doi.org/10.1515/9783110253535.1558.
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Taber, Douglass. "Enantioselective Construction of Arrays of Stereogenic Centers." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0042.
Full textAbstract:
An impressive array of new catalysts for enantioselective homologation have been reported. Carlos F. Barbas III of Scripps/La Jolla has found (Angew. Chem. Int. Ed. 2007, 46, 5572 ) that the commercial amino acid 3 mediated the addition of dihydroxyacetone 2 to an aldehyde such as 1 to give the triol 4 with high enantio- and diastereocontrol. Takashi Ooi of Nagoya University has devised (J. Am. Chem. Soc. 2007, 129, 12392) the catalyst 6 for the anti addition (Henry reaction) of nitro alkanes such as 5 to aldehydes. Takayoshi Arai of Chiba University has developed (Organic Lett. 2007, 9, 3595) a complementary catalyst (not shown) that mediated syn addition. Jonathan A. Ellman of the University of California, Berkeley has uncovered (J. Am. Chem. Soc. 2007, 129, 15110) the catalyst 10 for the aza-Henry reaction. Yian Shi of Colorado State University has found (J. Am. Chem. Soc. 2007, 129, 11688) ligands for Pd that direct the absolute sense of the addition of 13 to dienes such as 12. Bernhard Breit of Albert-Ludwigs-Universität, Freiburg has devised conditions (Adv. Synth. Cat. 2007, 349, 1891) for the Rh-catalyzed hydroformylation of α-olefins such as 15, and same-pot proline-catalyzed condensation of the linear aldehyde so produced with a branched aldehyde such as 17 to give, after reductive workup, the branched diol 18. Scott G. Nelson of the University of Pittsburgh has established (J. Am. Chem. Soc. 2007, 129, 11690) conditions, using Cinchona alkaloid derived catalysts, for the condensation of the imine surrogate 19 with the ketene precursor 20, to give the Mannich product 21. Scott E. Schaus of Boston University has developed (J. Am. Chem. Soc. 2007, 129, 15398) a complementary approach, based on catalyzed addition of isolated allyl borinates such as 23 to the activated imine 22. Kálmán J. Szabó of Stockholm University has found (J. Am. Chem. Soc. 2007, 129, 13723) that substituted allyl borinates can be prepared and reacted in situ. Martin Hiersemann of the Universität Dortmund has reported (Organic Lett. 2007, 9, 4979) the remarkable Cu*-catalyzed Claisen rearrangement of the prochiral 24, leading to 25 and thus to the versatile intermediate 27.
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Taber, Douglass F. "Enantioselective Synthesis of Alcohols and Amines: The Fujii/Ohno Synthesis of (+)-Lysergic Acid." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0035.
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Ramón Gómez Arrayás and Juan C. Carretero of the Universidad Autónoma de Madrid effected (Chem. Commun. 2011, 47, 6701) enantioselective conjugate borylation of an unsaturated sulfone 1, leading to the alcohol 2. Robert E. Gawley of the University of Arkansas found (J. Am. Chem. Soc. 2011, 133, 19680) conditions for enantioselective ketone reduction that were selective enough to distinguish between the ethyl and propyl groups of 3 to give 4. Vicente Gotor of the Universidad de Oviedo used (Angew. Chem. Int. Ed. 2011, 50, 8387) an overexpressed Baeyer-Villiger monoxygenase to prepare 6 by dynamic kinetic resolution of 5. Li Deng of Brandeis University prepared (J. Am. Chem. Soc. 2011, 133, 12458) 8 in high ee by kinetic enantioselective migration of the alkene of racemic 7. Bernhard Breit of the Freiburg Institute for Advanced Studies established (J. Am. Chem. Soc. 2011, 133, 20746) the oxygenated quaternary center of 10 by the addition of benzoic acid to the allene 9. Keith R. Fandrick of Boehringer Ingelheim constructed (J. Am. Chem. Soc. 2011, 133, 10332) the oxygenated quaternary center of 13 by enantioselective addition of the propargylic nucleophile 12 to 11. Yian Shi of Colorado State University devised (J. Am. Chem. Soc. 2011, 133, 12914) conditions for the enantioselective transamination of the α-keto ester 14 to the amine 15. Professor Deng added (Adv. Synth. Catal. 2011, 353, 3123) 18 to an enone 17 to give the protected amine 19. Song Ye of the Institute of Chemistry, Beijing effected (J. Am. Chem. Soc. 2011, 133, 15894) elimination/addition of an unsaturated acid chloride 20 to give the γ-amino acid derivative 22. Frank Glorius of the Universität Münster added (Angew. Chem. Int. Ed. 2011, 50, 1410) an aldehyde 23 to 24 to give the amide 25. Sentaro Okamoto of Kanagawa University designed (J. Org. Chem. 2011, 76, 6678) an organocatalyst for the enantioselective Steglich rearrangement of 26, creating the aminated quaternary center of 27. Most impressive of all was the report (Org. Lett. 2011, 13, 5460) by Hélène Lebel of the Université de Montréal of the direct enantioselective C–H amination of 28 to give 29.
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Taber, Douglass F. "Enantioselective Construction of Alkylated Centers: The Shishido Synthesis of (+)-Helianane." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0038.
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Teck-Peng Loh of Nanyang Technological University developed (Org. Lett. 2011, 13, 876) a catalyst for the enantioselective addition of an aldehyde to the versatile acceptor 2 to give 3. Kirsten Zeitler of the Universität Regensburg employed (Angew. Chem. Int. Ed. 2011, 50, 951) a complementary strategy for the enantioselective coupling of 4 with 5. Clark R. Landis of the University of Wisconsin devised (Org. Lett. 2011, 13, 164) an Rh catalyst for the enantioselective formylation of the diene 7. Don M. Coltart of Duke University alkylated (J. Am. Chem. Soc. 2011, 133, 8714) the chiral hydrazone of acetone to give 9, then alkylated again to give, after hydrolysis, the ketone 11 in high ee. Youming Wang and Zhenghong Zhou of Nankai University effected (J. Org. Chem. 2011, 76, 3872) the enantioselective addition of acetone to the nitroalkene 12. Takeshi Ohkuma of Hokkaido University achieved (Angew. Chem. Int. Ed. 2011, 50, 5541) high ee in the Ru-catalyzed hydrocyanation of 15. Gregory C. Fu, now at the California Institute of Technology, coupled (J. Am. Chem. Soc. 2011, 133, 8154) the 9-BBN borane 18 with the racemic chloride 17 to give 19 in high ee. Scott McN. Sieburth of Temple University optimized (Org. Lett. 2011, 13, 1787) an Rh catalyst for the enantioselective intramolecular hydrosilylation of 20 to 21. Several general methods have been devised for the enantioselective assembly of quaternary alkylated centers. Sung Ho Kang of KAIST Daejon developed (J. Am. Chem. Soc. 2011, 133, 1772) a Cu catalyst for the enantioselective acylation of the prochiral diol 22. Hyeung-geun Park of Seoul National University established (J. Am. Chem. Soc. 2011, 133, 4924) a phase transfer catalyst for the enantioselective alkylation of 24. Peter R. Schreiner of Justus-Liebig University Giessen found (J. Am. Chem. Soc. 2011, 133, 7624) a silicon catalyst that efficiently rearranged the Shi-derived epoxide of 26 to the aldehyde 27. Amir H. Hoveyda of Boston College coupled (J. Am. Chem. Soc. 2011, 133, 4778) 28 with the alkynyl Al reagent 29 to give 30 in high ee. Kozo Shishido of the University of Tokushima prepared (Synlett 2011, 1171) 31 by the Mitsunobu coupling of m-cresol with the enantiomerically pure allylic alcohol.
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Taber, Douglass F. "Alkene Reactions: The Xu/Loh Synthesis of Vitamin A1." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0028.
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Abdolreza Rezaeifard and Maasoumeh Jafarpour of the University of Birjand devised (J. Am. Chem. Soc. 2013, 135, 10036) an easily-scaled protocol for the Mo-catalyzed “on water” epoxidation of an alkene 1 to 2, using molecular O₂. Needing to epoxidize the sensitive alkene 3 to 5, Douglass F. Taber of the University of Delaware developed (Org. Synth. 2013, 90, 350) a convenient preparation of mmol quantities of the versatile oxidant dimethyldioxirane 4. Robert H. Grubbs of Caltech showed (Angew. Chem. Int. Ed. 2013, 52, 9751) that the Wacker oxidation of internal alkenes could proceed with high regioselectivity, as exemplified by the conversion of 6 to 7. David A. Nicewicz of the University of North Carolina demonstrated (J. Am. Chem. Soc. 2013, 135, 10334) the remarkable anti-Markovnikov addition of the acid 9 to the alkene 8, to give 10. Pieter C. A. Bruijnincx and Robertus J. M. Klein Gebbink of the University of Utrecht established (Chem. Eur. J. 2013, 19, 15012) a robust one-pot protocol for epoxidation, epoxide hydrolysis and periodate cleavage, for the net oxidative cleavage of the alkene 11 to the aldehydes 12 and 13. Tomoki Ogoshi of Kanazawa University observed (Org. Lett. 2013, 15, 3742) that permanganate with a phase transfer catalyst could selectively oxidize the linear alkene 14 to 15 in the presence of branched alkenes. Davood Azarifar of Bu-Ali Sina University devised (Synlett 2013, 24, 1377) the reagent 17 as a useful alternative to ozone, as illustrated by the oxidation of 16 to 18. Ning Jiao of Peking University effected (J. Am. Chem. Soc. 2013, 135, 11692) the unsymmetrical cleavage of the alkene 19 to the nitrile aldehyde 20. Tiow-Gan Ong of the Academia Sinica added (Org. Lett. 2013, 15, 5358) 22 to the alkene 21 to give the linear product 23. This could be hydrolyzed to the acid, or reduced and hydrolyzed to the aldehyde. Joost N. H. Reek of the University of Amsterdam isomerized (ACS Catal. 2013, 3, 2939) the terminal alkene of 24 to the internal alkene, then hydroformylated that directly to give the α-methyl branched aldehyde 25.
Conference papers on the topic "Séc. 18-19"
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Сивухин, А. Н., В. А. Курючкин, and Д. С. Марков. "Изучение устойчивости бактерий рода Bacillus к воздействию различных концентраций нитрата свинца." In Научный диалог: Вопросы медицины. ЦНК МНИФ «Общественная наука», 2018. http://dx.doi.org/10.18411/spc-18-01-2018-19.
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Mukhopadhyay, Asima, Kaustav Basu, and William Helm. "Evaluation of supragastric lesser sac using a laparoscope during cytoreductive surgery in epithelial ovarian carcinoma: A site for occult metastasis." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685290.
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Background: The supragastric lesser sac (SGLS) is a site of metastasis from epithelial ovarian cancer (EOC). Since this region is difficult to access and represents a confluence of critical structures, it may be a barrier to complete cytoreductive surgery (CRS). Methods: The SGLS was explored in consecutive patients undergoing CRS with EOC. After a xipho-pubic laparotomy incision, the SGLS was examined; visualisation and treatment was aided by using a laparoscope. Resectable disease was cleared using the following methods alone or in combination: direct tumor excision, argon beam coagulation, plasma jet or electrocautery. Results: 30 patients were evaluated between November 2013 and August 2014 in NGOC, Gateshead. SGLSM was present in 21/30 (70%) of EOCs, 19/25 (76%) high grade serous disease, 21/26 (81%) stage ≥3 disease, 18/20 (90%) with PCI score ≥15, 12/15 (80%) with ascites ≥500 ml, 13/18 (72%) at primary surgery and 8/10 (80%) at interval surgery. Sites included: lesser omentum (11), caudate lobe (10), groove of ligamentum venosum (6), floor (20), upper recess (7), subpyloric space (6), FOW (13), coeliac axis (5), porta hepatis (6), anterior surface of pancreas (2) retro-pancreatic (2). Size of metastases: <2.5mm = 3, <1 cm = 8, ≥1 cm = 7. Pre-operative CT scan identified 4/22 (18%) cases. In 18/21 patients SGLSM was completely resected or ablated; there were no complications. End Result: Optimal 27/30 (90%) including no visible disease = 18, <2.5 mm = 5; 17/21 (81%) cases would have been ≥2.5 mm residual disease if SGLS was not evaluated/treated. In a further cohort of 30 patients evaluated at Tata Medical Center, Kolkata, SGLSM was present in 18 (60%) of patients. CC1 resection was obtained in >90% cases. Conclusion: EOC frequently metastasizes to the SGLS and is often resectable. Lack of meticulous examination may result in incomplete resection; evaluation should be performed at least in stage ≥3 disease when the surgical intent is total clearance of disease.
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Baker, Richard L., and Duane A. Nelson. "Nuclear Safety Analysis for Cassini Accidental Earth Reentries." In ASME 1999 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/imece1999-1150.
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Abstract An engineering analysis model for predicting the response and potential breakup of Cassini spacecraft nuclear fuel modules during accidental Earth reentries is described. Physical aspects considered include aerodynamics, aerothermodynamics, thermostructural loads and ablation response. The extreme velocity, 19 km/sec, of an inadvertent reentry during the Earth gravity-assist flyby requires the development of a new model to predict the dominant radiative heating rates. Uncertainty estimates are established for each of the major factors in the model. Sensitivity analyses are also carried out to determine the effect of off-nominal environments on the predicted outcome. This allows output from the calculations to be expressed as a probability density function for atmospheric fuel release. It is concluded that 18 to 36 percent of the nuclear fuel contained in the spacecraft will be released as respirable material if reentry occurs.
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Bounameaux, H., Ph de Moerloose, J. Vogel, G. Reber, B. Krahenbuhl, and C. Bouvier. "NORMAL PREGNANCY AND DELIVERY IN A PATIENT WITH SEVERE PROTEIN C DEFICIENCY AND PREVIOUS DEEP-VEIN THROMBOSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644312.
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Congenital protein C (PC) deficiency is associated with thrombophilia. Heterozygotes with about half-normal plasma PC levels may present with venous thromboembolic events usually beginning during adolescence or young adulthood. A 26-year-old swiss woman had experienced an iliofemoral deep-vein thrombosis without obvious etiology six years.ago. In June, 1986 very low levels of PC antigen (25 %) and activity (27 %) were found when she was six-month pregnant. Three other family members (62, 24 and 19-year-old) had PC levels around 50 % but were symptomfree. Because of the post-thrombotic~syndrome and the pregnancy, ambulatory heparin therapy was immediately started in the patient (10-16'000 IU twice daily, s.c.) in order to maintain a plasma heparin level between 0.2 and 0.5 U/ml six hs after the morning injection. Delivery was induced at full-term whilst heparin was stopped for a few hours. Four weeks after delivery anticoagulation was discontinued and, so far, the patient remained symptomfree. The newborn showed no perinatal problem and the PC antigen level assayed in the umbilical venous blood was 22 % (normal range in the literature 18-46 %). Antithrombin III and protein S levels as well as fibtinolytic potential were within normal values in all family members.Conclusions. 1) Only one out of four heterozygote PC deficient family members had presented with venous thromboembolism. 2) The symptomatic subject had the lowest PC level in the family (activity and antigen around 25 %). 3) This woman experienced an event-free pregnancy and delivery although heparin was started only in the sixth month of pregnancy. 4) Thus, penetrance of the thrombotic trait may be quite variable (and low) amongst PC deficient heterozygotes, an observation which raises the question of the indication of long-term anticoagulation in these individuals. 5) Pregnancy did not affect the PC antigen and activity levels in our patient.
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Panok, Vitalii, and Iryna Tkachuk. "Social-Psychological problems of pedagogues in conditions pandemic of COVID-19." In National Events on WMHD in Ukraine. N-DSA-N, 2021. http://dx.doi.org/10.32437/nmhdup2021.4.
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Introduction. The COVID-19 pandemic may have hit the education industry the hardest, but the socio-psychological effects of quarantine are still poorly understood. A group of scientists from the Ukrainian SMC of practical psychology and social work of the NAES of Ukraine has conducted a study of the socio-psychological problems that have arisen for teaching staff of general secondary education establishments in the context of the pandemic. Purpose. The research was carried out during the implementation of the scientific topic «Overcoming the consequences of the COVID-19 pandemic in the activities of the psychological service of the educational system» on the order of the National Research Fund of Ukraine. Design\approach\methodology. The study was conducted by interviewing educators through Google forms. Most of the questions contained a 10-step scale. In processing the data, all respondents’ answers were grouped into 5 categories: "yes", "more likely to", "more likely not", "no", "don’t know/it’s hard to say". The survey was attended by 3,209 teaching staff from general secondary education institutions from all regions of Ukraine, 45% from urban areas, 55% from rural areas; among which 92% were women and 8% were men. Results. Among the results, researchers highlighted the difficulties and fears of educators caused by the pandemic. The fears and complexities of the profession were distributed as follows. 1. The fear of getting infected (infecting family members) is common to 78.2% of the surveyed. 40.9% of the interviewed felt this fear to the greatest extent. However, 9.3% found those fears irrelevant. 2. Problems associated with the use of ICT in educational activities (lack of competence) — 53.2%. Among those, 22.2% have major difficulties and 31% have minor difficulties. Only 15.7% consider themselves fully competent. 3. 73% of educators noted difficulties in involving children in distance learning. This was the main problem for 12.8% of respondents. 4. «It is difficult to adhere to all anti-epidemic requirements in an educational institution to protect students» — 69.5% stated that this is one of the most significant problems of professional activity. 5. Emotional exhaustion, loss of emotional balance, excessive fatigue. 58.7% said that the problem was significant, of which almost 18% said it was very significant. 6. 51.1% of respondents indicated that they were unable to communicate with students' parents regarding monitoring the quality of their students' knowledge. Of these, 8.7% rated it with the highest score. 7. Health related difficulties (consequential of COVID-19). 31.2% of educators consider this problem to be relevant, while 8.9% rated it as very relevant. 30.4% of those interviewed denied the existence of such a problem. Conclusions Taking into account the results of the study, the most relevant areas in the work of the psychologists in the educational system are the following: ● prevention among educators and students of the COVID-bullying; ● working with negative emotional states of participants in the educational process and increasing their stress tolerance; ● providing socio-educational assistance to children and families in difficult life situations, and forming positive life prospects. Keywords. COVID-19 pandemic; pedagogues; social-psychological problems; fear of getting infected; emotional exhaustion
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Napoleão, Reggyane Maria Souza, Artur de Sousa Costa, Kaline Emanuely Rodrigues Andrade, Juliana Pinho da Silva, Érika Ribeiro Barbosa, and Romão Alves do Nascimento Neto. "CYNICLOMYCES GUTTULATUS EM CANINOS: REVISÃO DE LITERATURA." In I Congresso On-line Nacional de Clínica Veterinária de Pequenos Animais. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2388.
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Introdução: O Cyniclomyces Guttulatus é um fungo ascomiceto do filo Ascomycota integrante da microbiota gastrointestinal de lagomorfos, roedores e frequentemente é observado em fezes de cães clinicamente normais. O fungo está associado a infecções oportunistas em cães, levando o animal a quadros de diarreia crônica e vômito. Reside na mucosa do fundo gástrico e piloro e são liberados pelo trato gastrointestinal no ambiente onde permanecem viáveis por um longo período de tempo, pois possuem a habilidade de formar ascósporos. Objetivo: Relatar sobre o Cyniclomyces Guttulatus em caninos no Brasil e no mundo atualmente. Material e Métodos: O presente artigo trata-se de uma revisão de literatura, entre 2010 e 2021, ressalvo artigos históricos, sendo os mesmos em inglês e/ou português, das bases de dados veterinary microbiology, PubVet, SciELO e Bull Soc Pathol Exot, utilizando para pesquisa as palavras: fungo, cães, fezes. Resultados: O Cyniclomyces Guttulatus foi descrito em várias regiões do mundo. Um estudo realizado na Holanda observou-se incidência de C. guttulatus em fezes de 18% (25/140) de cães saudáveis e 19% (57/300) de cães com diarreia. No Brasil, há relato de uma frequência de 2,26% em um estudo onde foram analisadas amostras de fezes de 221 cães domiciliados atendidos em serviço de saúde animal do Rio de Janeiro, RJ. Os principais sinais clínicos são diarreia crônica ou aguda e vômito. O exame coproparasitológico é a principal forma de diagnóstico e o tratamento é feito com antifúngico sistêmico de amplo espectro e baixo efeito tóxico. Pelo fato de ser encontrado nas fezes de cães saudáveis, alguns autores, sugerem que C. guttulatus seja um agente oportunista, não sendo a causa primária e pode ser decorrente da queda da imunidade destes animais, permitindo sua infecção. Conclusão: Podemos concluir que C. guttulatus é um microrganismo comum em cães hígidos. Portanto fica claro a necessidade de incluí-lo na lista de diagnóstico diferencial de diarreia crônica em cães.