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Journal articles on the topic 'SECEL'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Finizia, Caterina A., Mia Johansson, and Anna Rydeé. "S184 – Communication Experiences and QOL after Laryngeal Cancer." Otolaryngology–Head and Neck Surgery 139, no. 2_suppl (2008): P137—P138. http://dx.doi.org/10.1016/j.otohns.2008.05.358.

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Objectives 1) To investigate the sensitivity to change of the Swedish Self-Evaluation of Communication Experiences after Laryngeal Cancer questionnaire (S-SECEL), addressing communication dysfunction in patients treated for laryngeal cancer. 2) To evaluate longitudinal score changes in relation to established and validated quality of life instruments. Methods 100 patients with Tis-T4 laryngeal cancer were included prior to treatment onset. Patients answered 4 questionnaires at 6 occasions during 1 year; the S-SECEL, the EORTC Quality of Life Questionnaire, the EORTC Head and Neck cancer module, and Hospital Anxiety and Depression (HAD) scale. In addition, performance status was assessed. Differences within groups were tested with the Wilcoxon paired signed ranks test and between-group analyses were carried out using the Mann-Whitney U test. Magnitude of group differences was analyzed by means of effect sizes. Results S-SECEL was well accepted with a response rate of 76%. Communication dysfunction increased at 1 month, followed by a continuous decrease throughout the year. Changes were statistically significant at most measurement (p < 0.001), demonstrating the sensitivity of the S-SECEL to changes in communication over time. The S-SECEL was more sensitive than EORTC regarding communication dysfunction. Conclusions The questionnaire was responsive to change and showed convergent results when compared to established HRQL questionnaires. As a routine screening instrument, the S-SECEL could be a valuable tool for identifying patients at risk for psychosocial problems, to help plan rehabilitation and in-depth counselling. It is therefore recommended for clinical use in evaluation of communication dysfunction for all patients with laryngeal cancer, irrespective of treatment.

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2

Blood, Gordon W. "Development and Assessment of a Scale Addressing Communication Needs of Patients With Laryngectomies." American Journal of Speech-Language Pathology 2, no. 3 (1993): 82–90. http://dx.doi.org/10.1044/1058-0360.0203.82.

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This article deals with the development and assessment of the Self-Evaluation of Communication Experiences After Laryngectomy (SECEL), a 35-item scale developed to address the communication needs of patients with laryngectomies. In the initial stages of development of SECEL, 431 patients with laryngectomies participated. Scale development, factor structure, and data reduction are discussed. Statistical analyses revealed three factors representing General, Environment, and Attitude Subscales. The final version of the SECEL was administered to another 102 patients with laryngectomies to determine validity and reliability measurements. The scale provides a useful measure of adjustment related to communication experiences of patients with laryngectomies.

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3

Kiss, Beáta, Boris Casautanu, and Adriana Neagos. "The influence of vocal rehabilitation methods on communication in patients with total laryngectomy." Romanian Journal of Rhinology 11, no. 43 (2021): 118–24. http://dx.doi.org/10.2478/rjr-2021-0020.

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Abstract BACKGROUND. Considering the problematic social integration after total laryngectomy, evaluation of communicational aptitudes of patients after the surgical intervention is necessary in order to optimize their vocal rehabilitation process. MATERIAL AND METHODS. A prospective clinical study was conducted on 24 randomly selected patients of the Otolaryngology Clinic of Targu Mures County Emergency Clinical Hospital that underwent total laryngectomy. We adapted and implemented the questionnaire for Self-Evaluation of Communication Experiences after Laryngectomy – SECEL. Three groups of patients were created: the first containing those with voice prosthesis, the second those using electrolarynx and esophageal voice, and the third with no rehabilitation. We used the Kruskal-Wallis test for the statistical analysis of the results. RESULTS. The mean age of the patients included in our study group was 63 years (+/− 7.56 SD). 95.83% of the participants were male. 79.16% were married. The majority (87.50%) of patients were retired. In 75% of cases, 0 to 5 years have passed since the surgery. 75% reported diminished communication after surgery. The test used to determine if significant differences were present between the examined groups showed a p-value of 0.1329 (total scores), p-value of 0.3244 (the first score of SECEL), p-value = 0.6004 (the second score of SECEL) and a p-value of 0.0613 (the third score of SECEL). Given that p was higher than 0.05, the null hypotheses could not be rejected. The patients who underwent rehabilitation by tracheoesophageal prosthesis showed the best results in all tested categories. CONCLUSION. The SECEL questionnaire adapted in Romanian language could be used as a valid screening instrument in order to improve voice rehabilitation, but it needs further testing.

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Guimarães, Isabel, Gabriela Torrejano, Raquel Aires, et al. "Self-evaluation of communication experiences after laryngectomy (SECEL): translation and psychometric properties in European Portuguese." Logopedics Phoniatrics Vocology 45, no. 2 (2019): 66–72. http://dx.doi.org/10.1080/14015439.2019.1615544.

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5

Farias, Kassia Suelen da Silva, Juliana Azevedo Hamoy, Thiliane Regina Barbosa Meguis, Mirleide Chaar Bahia, and Silvio José de Lima Figueiredo. "Políticas Públicas de Lazer na Amazônia (Belém, Pará)." LICERE - Revista do Programa de Pós-graduação Interdisciplinar em Estudos do Lazer 20, no. 3 (2017): 139–62. http://dx.doi.org/10.35699/1981-3171.2017.1689.

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Esse estudo objetiva discorrer sobre as Políticas Públicas de Lazer na Amazônia (Belém-Pará). A pesquisa é de cunho qualitativo, exploratório, com levantamento bibliográfico, a partir de produções disponíveis da área. Na pesquisa local, utilizaram-se estudos de Lima et al. (2011), Bahia (2014), sites das Secretarias (Estadual/SEEL e Municipal/SEJEL) e análise de programas, projetos e ações de lazer de Belém, com análise de conteúdo (BARDIN, 2006). Percebeu-se que a SEJEL demonstra preocupação em despertar uma visão crítica das vivências do lazer, com acesso a uma diversidade de conteúdos. Por outro lado, os objetivos da SEEL demonstraram pouca diversidade no acesso aos conteúdos, revelando que as propostas convergem para práticas físico-esportivas. De forma geral, as Políticas Públicas de Lazer das Secretarias não são suficientes para o acesso da população de Belém.  

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6

Arnold, Sonya Rae, Diane Spicer, Boris Kouseff, Atilano Lacson, and Enid Gilbert-Barness. "Seckel-like Syndrome in Three Siblings." Pediatric and Developmental Pathology 2, no. 2 (1999): 180–87. http://dx.doi.org/10.1007/s100249900107.

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Seckel syndrome has been described as the prototype of the primordial bird-headed type of dwarfism. Since Seckel originally defined the disorder, less than 60 cases have been reported. In addition to the characteristic craniofacial dysmorphism and skeletal defects, abnormalities have been described in the cardiovascular, hematopoietic, endocrine, and central nervous systems. This pleiotropy has implied genetic heterogeneity and prompted reviews of previously reported cases of Seckel syndrome. As a result, the characteristic diagnostic features of Seckel syndrome have been highly debated. Although deletions in chromosome 2q have been described, to date, no genetic defect has been defined. We report three cases of Seckel-like syndrome in siblings from nonconsanguinous Caucasian parents. In addition to the typical Seckel phenotypic features, all three cases were characterized by severe hydrocephalus. We review the literature and propose that there is a spectrum of Seckel conditions that share some common key features, but also demonstrate a wide range of phenotypic features.

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Cherian, Mathew Punnachalil. "Seckel-like syndrome or Seckel variants?" Annals of Saudi Medicine 24, no. 6 (2004): 469–72. http://dx.doi.org/10.5144/0256-4947.2004.469.

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8

Meizri Wahyuningsih and Dudung Hamdun. "Komparasi Efektifitas Media Aplikasi Secil: Belajar Bahasa Arab dengan Suara dengan Komik Strip dalam Penguasaan Mufradāt Siswa Kelas IV SD Muhammadiyah Banguntapan." EDULAB: Majalah Ilmiah Laboratorium Pendidikan 5, no. 2 (2021): 152–71. http://dx.doi.org/10.14421/edulab.2020.52-04.

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The lack of media use during mufradāt learning in grade 4 SD Muhammadiyah Banguntapan was the background for researchers to try out the Secil application media: Learning Arabic + Voice and comic strips. This study aims to determine the effectiveness of learning mufradāt using the Secil application media and comic strip media, and whether or not there is a significant difference between the learning outcomes of the Secil application media user group and the comic strip media. This research is a quantitative study with a comparative research type. This research design used a quasi-experiment. Collecting data using observation, documentation, interviews, and tests. The data analysis technique used the Independent Sample t-Test and the Gain Score test through Microsoft Excel 2016. The results of this study concluded that mufradāt learning with the Secil application media was more effective than comic strip media. Evidenced by the comparison value of the n-gain of the two media is 1.78> 1, which means the effectiveness value of group 1> group 2. Then there is a significant difference between the learning outcomes of the two groups. Based on the results of the Independent Sample t-Test, which shows a significance value of 0.01 <0.05, which means that the application media of Secil: Learning Arabic + Voice is more effective than comic strips in improving mufradāt mastery of 4th-grade students of SD Muhammadiyah Banguntapan. Abstrak: Kurangnya pemanfaatan media saat pembelajaran mufradāt di kelas 4 SD Muhammadiyah Banguntapan melatarbelakangi peneliti untuk mengujicobakan media aplikasi Secil: Belajar Bahasa Arab+Suara dan komik strip. Penelitian ini bertujuan untuk mengetahui efektifitas pembelajaran mufradāt dengan menggunakan media aplikasi Secil dan media komik strip, dan ada atau tidaknya perbedaan yang signifikan antara hasil belajar kelompok pengguna media aplikasi Secil dengan media komik strip. Penelitian ini merupakan penelitian kuantitatif dengan jenis penelitian komparatif. Desain penelitian ini menggunakan quasi experiment. Pengumpulan data menggunakan observasi, dokumentasi, wawancara dan test. Adapun teknik analisis data menggunakan uji Independent Sample t-Test dan Gain Score melalui Microsoft Excel 2016. Hasil dari penelitian ini memperoleh kesimpulan bahwa pembelajaran mufradāt dengan media aplikasi Secil lebih efektif daripada media komik strip. Dibuktikan dengan nilai perbandingan n-gain kedua media ialah 1,78 > 1, yang berarti nilai efektifitas kelompok 1 > kelompok 2. Kemudian terdapat perbedaan yang signifikan antara hasil belajar kedua kelompok. Didasarkan pada hasil uji Independent Sample t-Test yang menunjukkan nilai signifikansi 0,01 < 0,05, yang artinya media aplikasi Secil: Belajar Bahasa Arab+Suara lebih efektif daripada komik strip dalam meningkatkan penguasaan mufradāt siswa kelas 4 SD Muhammadiyah Banguntapan.

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9

Pereda, Carlos. "DO FREE MINDS EXIST?" Tópicos, Revista de Filosofía 36, no. 1 (2013): 143. http://dx.doi.org/10.21555/top.v36i1.130.

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El autor explora algunas consecuencias inesperadas del artículo de Martin Seel. Para ello, reconstruye, a partir del texto de Seel, un argumento sobre la existencia de las mentes libres. La reconstrucción es en cierto sentido extravagante y fuertemente separada del texto de Seel, tomando como modelo el argumento sobre el mundo exterior de Moore (I). Después se considera brevemente ambos argumentos (II), para luego tomar de nuevo los conceptos de deliberación y razón usados por Seel (III). Por último, Pereda se pregunta en qué sentido pueden ser defendidos los argumentos de Seel y Moore (IV) y qué consecuencias tendría hacerlo.

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10

Muñoz Valverde, David, and Clara Muñoz Mediavilla. "VII Jornada Científica SECAL/7th SECAL Scientific Meeting." Laboratory Animals 51, no. 2 (2017): 226–27. http://dx.doi.org/10.1177/0023677217699551.

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Hevia, Elena. "SECAL en modo pandemia/SECAL in pandemic mode." Laboratory Animals 54, no. 5 (2020): 502–5. http://dx.doi.org/10.1177/0023677220953385.

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12

Qu, Kai, Chanjie Li, and Feiyu Zhang. "Asymptotic and stability analysis of solutions for a Keller Segel chemotaxis model." Concurrent Engineering 29, no. 1 (2021): 75–81. http://dx.doi.org/10.1177/1063293x21998087.

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A kind of Keller Segel chemotaxis model has a wide range of applications, but its coupling relationship is very complex. The commonly used method of constructing the upper and lower solutions is no longer suitable for the model solution, which results in a long time for its analysis. In this paper, we propose a method to analyze the asymptotic behavior and stability of a Keller Segel chemotaxis model. The previous methods of first formally and then rigorously, the asymptotic expansion of these monotone steady states, and then we use this fine information on the spike to prove its local asymptotic stability. Moreover, we obtain the uniqueness of such steady states. The asymptotic behavior of the solution of a Keller Segel chemotaxis model is analyzed, and the asymptotic rate is calculated; According to the limitation of Neumann boundary condition, the complete blow up of chemotaxis model solution and the stability of the initial value of the complete blow up time are studied, and the asymptotic and stability analysis of a kind of Keller Segel chemotaxis model solution is completed. The experimental results show that the proposed method takes less time to solve a kind of Keller Segel chemotaxis model, improves the efficiency of the solution, and the accuracy of the solution is higher.

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13

Akio, Takenaka, Oguma Hiroyuki, Amagai Yukihiro, and Ishihama Fumiko. "SecSel, a new software tool for conservation prioritization that is applicable to ordinal-scale data for multiple biodiversity features." PLOS ONE 16, no. 7 (2021): e0247737. http://dx.doi.org/10.1371/journal.pone.0247737.

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SecSel, a protected-area prioritization tool, has been developed to help design areas that efficiently protect multiple features, including conservation of biodiversity and use of ecosystem services. The prioritization by SecSel is based on evaluation of the local units of each feature. The evaluation metrics should be quantitative but need not be ratio scale. The minimum requirement of the input data is that they are ordinal. The conservation target is the number of local units with high values of each feature to be protected in the area. SecSel can handle conflicts among features, including conflicts between conservation and utilization of land or specific ecosystem functions. Before the selection procedure, one of a conflicting pair of features in a site is discarded. That decision is based on the dispensability of the local unit to fulfilling the conservation target of each feature. SecSel also considers the cost of including each site in the protected area and the compactness of the area in terms of total boundary length or the distance to the nearest site. To demonstrate the functionality of Secsel, we used it to design land use in an alpine region of northern Japan where conservation of alpine vegetation and its recreational use are important considerations.

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Hevia, Elena. "Una SECAL cada vez más grande/A bigger SECAL." Laboratory Animals 54, no. 4 (2020): 402–3. http://dx.doi.org/10.1177/0023677220940617.

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15

Krah, Franziska. "Mit den Waffen der Aufklärung gegen den Antisemitismus." Zeitschrift für Religions- und Geistesgeschichte 63, no. 2 (2011): 122–44. http://dx.doi.org/10.1163/157007311795244338.

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AbstractThe rise of political anti-Semitism in Imperial and Weimar Germany met with public opposition initiated primarily by Jews. From various perspectives, jewish journalists and intellectuals investigated the origin of this anti-Semitism, its different manifestations as well as possibilities of its public rejection. Journalist Binjamin W. Segel (1866-1931) hereby focused his efforts on debunking antiSemitic myths, such as the Jewish World Conspiracy, as popularized by the text "The protocols of the Elders of Zion". In his writings, Segel, with an Eastern European background, pays attention to the discrimination of "Ostjuden" (EastEuropean Jews) in particular. Furthermore, Segel deals with questions regarding the origins of anti-Semitism, and the effectiveness of Jewish opposition towards it. The following article outlines his life and discusses his work.

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Cunning, David. "SEMEL IN VITA." Faith and Philosophy 24, no. 2 (2007): 165–84. http://dx.doi.org/10.5840/faithphil200724226.

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17

Teleanu, R., M. Moiceanu, A. Lazar, F. Buruiana, D. Plesca, and D. Dragomir. "DMP013 Seckel syndrome." European Journal of Paediatric Neurology 11 (September 2007): 79. http://dx.doi.org/10.1016/s1090-3798(08)70552-x.

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18

Cada, Dennis J. "Semel Pro Semper." Hospital Pharmacy 49, no. 6 (2014): 493. http://dx.doi.org/10.1310/hpj4906-493.

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LI, TONG, and ZHI-AN WANG. "NONLINEAR STABILITY OF LARGE AMPLITUDE VISCOUS SHOCK WAVES OF A GENERALIZED HYPERBOLIC–PARABOLIC SYSTEM ARISING IN CHEMOTAXIS." Mathematical Models and Methods in Applied Sciences 20, no. 11 (2010): 1967–98. http://dx.doi.org/10.1142/s0218202510004830.

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Traveling wave (band) behavior driven by chemotaxis was observed experimentally by Adler1,2 and was modeled by Keller and Segel.15 For a quasilinear hyperbolic–parabolic system that arises as a non-diffusive limit of the Keller–Segel model with nonlinear kinetics, we establish the existence and nonlinear stability of traveling wave solutions with large amplitudes. The numerical simulations are performed to show the stability of the traveling waves under various perturbations.

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BORSCHE, R., S. GÖTTLICH, A. KLAR, and P. SCHILLEN. "THE SCALAR KELLER–SEGEL MODEL ON NETWORKS." Mathematical Models and Methods in Applied Sciences 24, no. 02 (2013): 221–47. http://dx.doi.org/10.1142/s0218202513400071.

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In this work, we extend the one-dimensional Keller–Segel model for chemotaxis to general network topologies. We define appropriate coupling conditions ensuring the conservation of mass and show the existence and uniqueness of the solution. For our computational studies, we use a positive preserving first-order scheme satisfying a network CFL condition. Finally, we numerically validate the Keller–Segel network model and present results regarding special network geometries.

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Djiwo, Soeparno, Gerald A. Pohan, and Djoko H. Praswanto. "DRYER SEGEL BOTOL PLASTIK UNTUK PENINGKATAN KWALITAS KEMASAN BOTOL VITAMIN UNGGAS DI KECAMATAN PURWOSARI KABUPATEN PASURUAN." JURNAL APLIKASI DAN INOVASI IPTEKS "SOLIDITAS" (J-SOLID) 1, no. 2 (2019): 84. http://dx.doi.org/10.31328/js.v1i2.901.

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Pada sistem penjualan sebuah produk, ada beberapa faktor yang mempengaruhinya. Salah satu faktor yang mempengaruhi perhatian konsumen yaitu kemasan / packaging. Kemasan mempunyai efek yang signifikan terhadap hasil penjualan. Hal ini dikarenakan desain kemasan yang digunakan pada sebuah produk dapat menunjukkan bahwa produk tersebut benar-benar mempunyai kwalitas. Meskipun produk yang dijual tersebut belum terkenal di masyarakat, hal pertama yang dilihat untuk memastikan produk tersebut kwalitas terjamin dilihat dari desain kemasan yang digunakan. Pada jaman milenial sekarang ini, model kemasan bermacam – macam. UKM – UKM yang muncul ditengah masyarakat mulai memperbaiki kemasan untuk meningkatkan harga jual produknya. Salah satunya UKM di Kecamatan Purwosari Kabupaten Pasuruan, UKM yang bergerak dibidang vitamin unggas ini mulai mementingkan model kemasan yang digunakan. Pada UKM tersebut untuk mengemas produknya agar menarik peternak, menggunakan kemasan botol. Hal ini dikarenakan kemasan botol dapat menjaga produknya dari faktor-faktor lain yang dapat merusak kwalitas produk. Untuk menjamin keaslian produk, digunakan segel plastik pada botol tersebut. Dalam proses pembuatan segel menggunakan dryer yang didesain sesuai model botol agar dapat menghasilkan segel botol yang maksimal sehingga menraik untuk dilihat oleh konsumen. Dari hasil yang didapat dengan menggunakan dryer segel botol ini, kemasan botol vitamin terlihat rapi dan menarik serta dapat meningkatkan permintaan konsumen 50% dari sebelumnya.

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22

Culatta, Barbara, Richard Aslett, Megan Fife, and Lee Ann Setzer. "Project SEEL." Communication Disorders Quarterly 25, no. 2 (2004): 79–88. http://dx.doi.org/10.1177/15257401040250020501.

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Culatta, Richard, Barbara Culatta, Meghan Frost, and Krista Buzzell. "Project SEEL." Communication Disorders Quarterly 25, no. 2 (2004): 89–96. http://dx.doi.org/10.1177/15257401040250020601.

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Culatta, Barbara, Lee Ann Setzer, Candy Wilson, and Richard Aslett. "Project SEEL." Communication Disorders Quarterly 25, no. 3 (2004): 127–39. http://dx.doi.org/10.1177/15257401040250030401.

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25

Mori, Hiroyuki, Yoshinori Akiyama, and Koreaki Ito. "A SecE Mutation That Modulates SecY-SecE Translocase Assembly, Identified as a Specific Suppressor of SecY Defects." Journal of Bacteriology 185, no. 3 (2003): 948–56. http://dx.doi.org/10.1128/jb.185.3.948-956.2003.

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ABSTRACT The SecY39(Cs) (cold-sensitive) alteration of Arg357 results in a defect of translocation initiation. As a means to dissect the Sec translocation machinery, we isolated mutations that act as suppressors of the secY39 defect. A specific secE mutation, designated secE105, was thus isolated. This mutation proved to be identical with the prlG2 mutation and to suppress a number of cold-sensitive secY mutations. However, other prlG mutations did not effectively suppress the secY defects. Evidence indicates that the Ser105-to-Pro alteration in the C-terminal transmembrane segment of SecE weakens SecY-SecE association. In vitro analyses showed that the SecE(S105P) alteration preferentially stimulates the initial phase of translocation. It is suggested that the S105P alteration affects the SecYEG channel such that it is more prone to open and to accept the translocation initiation domain of a preprotein molecule.

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Granados Fernández, Consolación. "Semine semel intra formandi hominis monetam locato, de Macrobio." Emerita 64, no. 2 (1996): 351–54. http://dx.doi.org/10.3989/emerita.1996.v64.i2.236.

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27

Permadi, Tedi. "STRUKTUR DAN KOMPONEN TIGA SURAT SEGEL TANAH DI PRIANGAN." Jumantara: Jurnal Manuskrip Nusantara 9, no. 2 (2019): 261. http://dx.doi.org/10.37014/jumantara.v9i2.252.

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Naskah kuno (manuscript) adalah salah satu bentuk tinggalan budaya masa lampau yang memuat beragam aspek kehidupan. Kandungan isi dan pesan teks naskah kuno secara fungsional berkorelasi dengan masyarakat pendukung budaya di masa lampau, pewaris budaya saat ini, dan generasi yang akan datang. Salah satu bentuk naskah kuno adalah surat segel tanah yang erat terkait dengan kepemilikan dan klaim atas tanah yang tercatat di dalamnya. Objek kajian ini berupa tiga surat segel tanah dari tahun 1903, 1906, dan 1911 yang berasal dari daerah Priangan, Jawa Barat. Metode yang digunakan adalah metode deksriptif analitis, bertujuan mendeskripsikan struktur dan komponen yang terdapat dalam objek penelitian. Adapun simpulan yang dapat diajukan adalah tidak terdapat adanya kesalahan tulis dan penyimpangan redaksional, terdapat adanya keseragaman struktur dan komponen surat segel tanah yang terdapat pada ketiga teks naskah, baik tata letak maupun isi yang menunjukkan sistem administrasi di tingkat pemerintahan desa sudah tertata baik.

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Murthy, Jyotsna, Krishna G. Seshadri, Padmasani Venkat Ramanan, Arvind Rajamani, and Altaf Hussain. "A Case of Cleft Lip and Palate Associated with Seckel Syndrome." Cleft Palate-Craniofacial Journal 41, no. 2 (2004): 202–5. http://dx.doi.org/10.1597/02-087.

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Objective We report an unusual association of complete cleft of the primary and secondary palate with Seckel syndrome. Seckel syndrome is a very rare syndrome, with only 60 reported cases in the medical literature. It is an autosomal recessive disorder characterized by birdlike face, intrauterine growth retardation, dwarfism, and microcephaly. This young child of 5 years had a successful cleft lip repair under general anesthesia. The main features of the syndrome and the technical problems of anesthesia and surgery are discussed.

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29

Sand-Jecklin, Kari. "Assessing Nursing Student Perceptions of the Clinical Learning Environment: Refinement and Testing of the SECEE Inventory." Journal of Nursing Measurement 17, no. 3 (2009): 232–46. http://dx.doi.org/10.1891/1061-3749.17.3.232.

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The Student Evaluation of Clinical Education Environment (SECEE) instrument was developed to provide information about the quality of the student clinical learning environment to assist clinical agencies, nursing faculty, and administers in selecting clinical sites that best promote student learning. The SECEE Version 3 was used in all clinical courses at a large mid-Atlantic university from 2001 to 2005. Data from more than 2,700 inventories were analyzed to assess instrument reliability and validity. Internal consistency reliability based on coefficient alpha was .94, with subscale alphas ranging from .82 to .94. Comparisons by analysis of variance revealed significant differences in student evaluations based on both clinical sites and clinical faculty. Confirmatory factor analysis supported the predetermined three factors (subscales) and subscale item content, except for two items. The SECEE Version 3 demonstrated strong internal consistency reliability and the ability to discriminate between student evaluations of distinct clinical sites and faculty and provided practically useful information to both faculty and agency staff.

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Swaving, Jelto, Karel H. M. van Wely, and Arnold J. M. Driessen. "Preprotein Translocation by a Hybrid Translocase Composed of Escherichia coli and Bacillus subtilis Subunits." Journal of Bacteriology 181, no. 22 (1999): 7021–27. http://dx.doi.org/10.1128/jb.181.22.7021-7027.1999.

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ABSTRACT Bacterial protein translocation is mediated by translocase, a multisubunit membrane protein complex that consists of a peripheral ATPase SecA and a preprotein-conducting channel with SecY, SecE, and SecG as subunits. Like Escherichia coli SecG, theBacillus subtilis homologue, YvaL, dramatically stimulated the ATP-dependent translocation of precursor PhoB (prePhoB) by theB. subtilis SecA-SecYE complex. To systematically determine the functional exchangeability of translocase subunits, all of the relevant combinations of the E. coli and B. subtilis secY, secE, and secG genes were expressed in E. coli. Hybrid SecYEG complexes were overexpressed at high levels. Since SecY could not be overproduced without SecE, these data indicate a stable interaction between the heterologous SecY and SecE subunits. E. coli SecA, but not B. subtilis SecA, supported efficient ATP-dependent translocation of the E. coli precursor OmpA (proOmpA) into inner membrane vesicles containing the hybrid SecYEG complexes, ifE. coli SecY and either E. coli SecE orE. coli SecG were present. Translocation of B. subtilis prePhoB, on the other hand, showed a strict dependence on the translocase subunit composition and occurred efficiently only with the homologous translocase. In contrast to E. coliSecA, B. subtilis SecA binds the SecYEG complexes only with low affinity. These results suggest that each translocase subunit contributes in an exclusive manner to the specificity and functionality of the complex.

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31

CHALUB, FABIO, YASMIN DOLAK-STRUSS, PETER MARKOWICH, DIETMAR OELZ, CHRISTIAN SCHMEISER, and ALEXANDER SOREFF. "MODEL HIERARCHIES FOR CELL AGGREGATION BY CHEMOTAXIS." Mathematical Models and Methods in Applied Sciences 16, supp01 (2006): 1173–97. http://dx.doi.org/10.1142/s0218202506001509.

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We present partial differential equation (PDE) model hierarchies for the chemotactically driven motion of biological cells. Starting from stochastic differential models, we derive a kinetic formulation of cell motion coupled to diffusion equations for the chemoattractants. We also derive a fluid dynamic (macroscopic) Keller–Segel type chemotaxis model by scaling limit procedures. We review rigorous convergence results and discuss finite-time blow-up of Keller–Segel type systems. Finally, recently developed PDE-models for the motion of leukocytes in the presence of multiple chemoattractants and of the slime mold Dictyostelium Discoideum are reviewed.

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32

Tibelius, Alexandra, Joachim Marhold, Hanswalter Zentgraf, et al. "Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1." Journal of Cell Biology 185, no. 7 (2009): 1149–57. http://dx.doi.org/10.1083/jcb.200810159.

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Primary microcephaly, Seckel syndrome, and microcephalic osteodysplastic primordial dwarfism type II (MOPD II) are disorders exhibiting marked microcephaly, with small brain sizes reflecting reduced neuron production during fetal life. Although primary microcephaly can be caused by mutations in microcephalin (MCPH1), cells from patients with Seckel syndrome and MOPD II harbor mutations in ataxia telangiectasia and Rad3 related (ATR) or pericentrin (PCNT), leading to disturbed ATR signaling. In this study, we show that a lack of MCPH1 or PCNT results in a loss of Chk1 from centrosomes with subsequently deregulated activation of centrosomal cyclin B–Cdk1.

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33

Donofrio, Gaetano, Ezio Bottarelli, Cavirani Sandro, and Cesidio Filippo Flammini. "Expression of Bovine Viral Diarrhea Virus Glycoprotein E2 as a Soluble Secreted Form in a Mammalian Cell Line." Clinical and Vaccine Immunology 13, no. 6 (2006): 698–701. http://dx.doi.org/10.1128/cvi.00071-06.

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ABSTRACT Bovine viral diarrhea virus (BVDV) membrane-anchored type I glycoprotein E2 is an ∼53-kDa immunodominant glycoprotein inducing the production of neutralizing antibodies in the animal host after natural infection or following immunization with live or killed vaccines. The E2 coding region lacking the transmembrane domain was constructed in a soluble secreted form (secE2) and expressed in the medium of a transiently transfected human cell line. The crude conditioned medium containing secE2 can be potentially employed to develop an enzyme-linked immunosorbent assay antigen for the diagnosis of BVDV infection or for vaccine purposes.

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34

Millichap, J. Gordon. "Seckel Syndrome with Holoprosencephaly." Pediatric Neurology Briefs 26, no. 4 (2012): 32. http://dx.doi.org/10.15844/pedneurbriefs-26-4-8.

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35

Kirkwood, Melanie. "Otherworld by Jason Segel." Bulletin of the Center for Children's Books 71, no. 4 (2017): 176. http://dx.doi.org/10.1353/bcc.2017.0890.

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36

Seifried, Klaus. "Segel setzen, Leinen los!" Lernen und Lernstörungen 7, no. 2 (2018): 125. http://dx.doi.org/10.1024/2235-0977/a000208.

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37

Coats, Karen. "Nightmares by Jason Segel." Bulletin of the Center for Children's Books 68, no. 4 (2014): 228. http://dx.doi.org/10.1353/bcc.2014.1052.

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38

Kumar, Konidena Venkata Subrahmanya Hari, and Konidena Aravinda. "Visual Vignette: Seckel Syndrome." Endocrine Practice 1, no. -1 (2012): 1–4. http://dx.doi.org/10.4158/ep11385.vvr.

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39

Sommer, Annemarie. "Photo essay—Seckel syndrome." American Journal of Medical Genetics Part C: Seminars in Medical Genetics 145C, no. 3 (2007): 230–31. http://dx.doi.org/10.1002/ajmg.c.30144.

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40

Codd, Patrick J., R. Michael Scott, and Edward R. Smith. "Seckel syndrome and moyamoya." Journal of Neurosurgery: Pediatrics 3, no. 4 (2009): 320–24. http://dx.doi.org/10.3171/2008.12.peds08205.

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Seckel syndrome is an autosomal recessive disorder characterized by intrauterine and postnatal growth delay, microcephaly with mental retardation, and facial dysmorphisms including micrognathia, a recessed forehead, and a large beaked nose. Occurring in 1 in 10,000 children without sex preference, it is the most common primordial microcephalic osteodysplastic dwarfism and has been associated with a variety of congenital brain malformations and intracranial aneurysms. Moyamoya syndrome is an idiopathic, chronic, progressive cerebrovascular disorder marked by stenosis of the intracranial internal carotid arteries and concurrent development of hypertrophied collateral vessels. These tortuous arterial collaterals appear radiographically as “puffs of smoke,” giving the syndrome its name. In this report, the authors describe the case of a 16-year-old girl with coincident Seckel and moyamoya syndromes. To their knowledge, this is the first reported case of such an association being treated with surgical revascularization. The patient presented with persistent headaches and a 2-year history of progressive hand, arm, and face numbness. Imaging studies revealed multiple completed cerebral infarcts, global ischemic changes, and vascular anatomy consistent with moyamoya syndrome. Bilateral pial synangioses successfully revascularized each hemisphere with resolution of the patient's symptoms. The patient died 1 year later of complications related to treatment of a rapidly progressing intracranial aneurysm. This report documents the first case associating moyamoya and Seckel syndromes. In addition, the report reveals the rapid development of an intracranial aneurysm in a patient with this syndrome. When coupled with previous reports of other types of cerebrovascular disease in patients with Seckel syndrome or other primordial dwarfisms, the authors' findings are important because they suggest that physicians treating patients with dwarfism should consider the diagnosis of moyamoya syndrome when symptoms suggestive of cerebral ischemia are present. Prompt diagnosis and treatment of moyamoya syndrome, including the use of proven surgical revascularization procedures such as pial synangiosis, may significantly improve the long-term outcomes of these patients.

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Gurkan, Yavuz, Tulay Hosten, Huban Dayioglu, Kamil Toker, and Mine Solak. "Anesthesia for Seckel syndrome." Pediatric Anesthesia 16, no. 3 (2006): 359–60. http://dx.doi.org/10.1111/j.1460-9592.2005.01798.x.

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42

Raffelt, Georg, and David Seckel. "Raffelt and Seckel reply." Physical Review Letters 68, no. 20 (1992): 3116. http://dx.doi.org/10.1103/physrevlett.68.3116.

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43

Süssmuth, Lisa. "Chemieunternehmen: Segel neu gesetzt." Nachrichten aus der Chemie 67, no. 1 (2019): 41. http://dx.doi.org/10.1002/nadc.20194084472.

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44

Carlson, Jerry. "Conversation with Senel Paz." Review: Literature and Arts of the Americas 54, no. 1 (2021): 128–31. http://dx.doi.org/10.1080/08905762.2020.1819059.

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45

Dotto, Dalva Maria Righi, Monica Elisa Dias Pons, José Martinho Rodrigues Remedi, and Lilian Coradini Cerezer. "GESTÃO DE TURISMO DE EVENTOS: CARACTERIZAÇÃO E REFLEXÕES SOBRE OS EVENTOS DA REGIÃO CENTRAL DO RIO GRANDE DO SUL/BRASIL." Revista Sociais e Humanas 29, no. 2 (2016): 125. http://dx.doi.org/10.5902/2317175821910.

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São recorrentes os estudos, os levantamentos e a elaboração de planos para o turismo, nas diferentes instâncias do setor público e privado. No Rio Grande do Sul, a Secretaria Estadual de Esporte, Turismo e Lazer (SETEL) divide o Estado em regiões para definir com mais precisão as políticas públicas e a organização do setor. Com ênfase no tema turismo de eventos e utilizando como recorte geográfico a região Central do Rio Grande do Sul, este estudo foi realizado através de uma pesquisa exploratória, com abordagem de investigação qualitativa e objetivou sistematizar os eventos divulgados pela SETEL, com análise por município e região e, mais especificamente, verificar os principais aspectos referentes a identificação dos organizadores, tipos de eventos, abrangência, periodicidade e a categorização dos municípios realizada pelo Ministério de Turismo. Os resultados da pesquisa demonstraram que há poucos organizadores de eventos que utilizam essa importante ferramenta gratuita de divulgação e atração de turistas disponibilizada através do website da SETEL. Também se constatou que a maioria dos eventos tem periodicidade anual, que há uma concentração maior no segundo semestre e que as parcerias entre setor público e privado para a realização de eventos ainda é incipiente na região estudada.

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46

Topham, C. M., and K. Brocklehurst. "In defence of the general validity of the Cha method of deriving rate equations. The importance of explicit recognition of the thermodynamic box in enzyme kinetics." Biochemical Journal 282, no. 1 (1992): 261–65. http://dx.doi.org/10.1042/bj2820261.

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1. The suggestion by Segel & Martin [(1988) J. Theor. Biol. 135, 445-453] that the well-known schematic method for the derivation of rate equations for combined quasi-equilibrium-steady-state models proposed by Cha [(1968) J. Biol. Chem. 243, 820-825] may not be generally applicable was shown to be incorrect. By contrast, Cha's method was shown (a) to yield correct initial-rate equations that are exact and (b) not to require any constraints on the relative magnitudes of rate constants for slow steps outside the quasi-equilibrium segments of the kinetic model, including those suggested by Segel & Martin. 2. Examination of residual King-Altman patterns for the general modifier model of Botts & Morales [(1953) Trans. Faraday Soc. 49, 696-707] revealed the reasons for the erroneous conclusions reached by Segel & Martin. The errors arise from the failure to take account of fluxes in parallel pathways that connect the two isolated groups of enzyme species existing in quasi-equilibrium with the modifier. 3. A similar failure to take explicit account of parallel pathways in a thermodynamic box that delayed proper appreciation of the form of pH-dependence of kcat/Km is briefly discussed.

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47

Wang, Daifang, Jin Zhou, Longhua Guo, Bin Qiu, and Zhenyu Lin. "A surface-enhanced electrochemiluminescence sensor based on Au-SiO2 core–shell nanocomposites doped with Ru(bpy)32+ for the ultrasensitive detection of prostate-specific antigen in human serum." Analyst 145, no. 1 (2020): 132–38. http://dx.doi.org/10.1039/c9an01935a.

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48

Azili, Esra, and Ömer Faruk Tutkun. "Ortaokul Öğretmenlerinin Görüşlerine Göre Ortaöğretim Merkezi Sınavı (LGS)’nin Üstünlükleri ve Sınırlıkları." Journal of Social Research and Behavioral Sciences 7, no. 13 (2021): 123–46. http://dx.doi.org/10.52096/jsrbs.6.1.7.13.7.

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The purpose of this research is to present the advantages and limitations of the Secondary Education Center Exam (SECE) conducted in 2017-2018 academic year in the opinions of middle school teachers. The study group of the research was consisted of 47 middle school teachers those who entered lessons the 8th grades as of the data collection period in Mamak district. As research method, semi-structured interview model, one of the qualitative research methods, was used in the study. As the data collection tool, structured interview form is applied. The data obtained from the interviews have been analyzed using the method of descriptive analysis. The findings obtained in the research are given below: 1- According to middle school teachers, the advantage of secondary education center exam as regards previous high school admission exams is high distinctiveness and limitation of SECE requires high-level skills. 2- The distinctiveness of successful/unsuccessful students of SECE is high when it comes to yes/no questions. However, it is not qualified to discern from students who is solving problems fast/practical and high level skilled. 3- In SECE, difficulty of skill-based questions is coherent with learning outcomes in secondary education curriculum. Nevertheless, they are not coherent with assessment of high-level behaviors, extent, content intelligibility and schoolbooks. 4- In SECE, assessment of basic skills stated and aimed to improve in secondary education curriculum is adequate. However, the aims in curriculum are not adequate to question high-level skills. 5- According to middle school teachers, student achievement was affected by the students mostly register the closest school to their home and there is no obligation to have an exam.

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49

Brandis, Gerrit, Sha Cao, and Diarmaid Hughes. "Operon Concatenation Is an Ancient Feature That Restricts the Potential to Rearrange Bacterial Chromosomes." Molecular Biology and Evolution 36, no. 9 (2019): 1990–2000. http://dx.doi.org/10.1093/molbev/msz129.

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Abstract The last common ancestor of the Gammaproteobacteria carried an important 40-kb chromosome section encoding 51 proteins of the transcriptional and translational machinery. These genes were organized into eight contiguous operons (rrnB-tufB-secE-rpoBC-str-S10-spc-alpha). Over 2 Gy of evolution, in different lineages, some of the operons became separated by multigene insertions. Surprisingly, in many Enterobacteriaceae, much of the ancient organization is conserved, indicating a strong selective force on the operons to remain colinear. Here, we show for one operon pair, tufB-secE in Salmonella, that an interruption of contiguity significantly reduces growth rate. Our data show that the tufB-secE operons are concatenated by an interoperon terminator–promoter overlap that plays a significant role regulating gene expression. Interrupting operon contiguity interferes with this regulation, reducing cellular fitness. Six operons of the ancestral chromosome section remain contiguous in Salmonella (tufB-secE-rpoBC and S10-spc-alpha) and, strikingly, each of these operon pairs is also connected by an interoperon terminator–promoter overlap. Accordingly, we propose that operon concatenation is an ancient feature that restricts the potential to rearrange bacterial chromosomes and can select for the maintenance of a colinear operon organization over billions of years.

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50

Kongnyuy, Michael, Arvin Koruthu George, Amogh Iyer, et al. "Tumor contact length: A novel multiparametric MRI predictor of prostate cancer outcomes." Journal of Clinical Oncology 34, no. 2_suppl (2016): 61. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.61.

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61 Background: Multiparametric MRI (MP-MRI) can visualize prostate tumors. MP-MRI characteristics (extraprostatic extension (ECE), tumor volume, etc.) can be predictive of final pathologic findings such as lymph node (LN) involvement, pathological ECE (pECE), and biochemical recurrence (BCR). These are pivotal in the decision-making process regarding treatment. Tumor contact length (TCL) is defined as the length of cancer in contact with the prostatic capsule. We evaluated the ability of MP-MRI determined TCL in predicting pECE, BCR and LN in patients undergoing radical prostatectomy. Methods: All patients who underwent a 3T MP-MRI at the NCI from 2007 to 2015 were retrospectively classed into no ECE, suspicious ECE (sECE) and frank ECE (fECE) based on MP-MRI findings. sECE was defined as tumor with capsular bulge on MRI while fECE was clear capsular obliteration and tumor extension beyond the prostatic capsule. Demographic data was obtained on patients with fECE and sECE on MP-MRI with the presence of pECE, LN, and BCR status following radical prostatectomy from a single surgeon (PP) experience. Chi-Square and Wilcoxon rank sum test were used to compare proportions and continuous variables respectively. Logistic regression was used to determine the predictive ability of TCL. Statistical significance was defined as p-value ≤0.05. Results: Of all 1,260 patients who underwent MP-MRI, we focused on 146 who had sECE (68) or fECE (78) on MP-MRI. Mean age was 60 years and median prostate specific antigen was 11.7 ng/ml. Logistic regression analysis showed that MP-MRI determined TCL was predictive of ECE (p=0.01), LN status (p=0.0001) on final pathology and BCR (p=0.05) during follow up. Patients with pECE had a longer median MP-MRI TCL (2.8 cm) compared to those without pECE (2.4 cm), p=0.04. When analyzed individually, fECE correlated with pECE (p=0.05) while s ECE did not correlate with pECE (p=0.11). Although, not statistically significant, the median MP-MRI TCL for sECE with pECE was still longer than in sECE with no pECE in the sub-group analysis. Conclusions: Longer TCL on MP-MRI can indicate presence of ECE, LN involvement at final pathology as well as predict BCR on follow up.

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