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Dissertations / Theses on the topic 'Second-line therapy'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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1

Mhangwane, Shushu Rirhandzu Comfort. "Predicting early and late first-line antiretroviral therapy virologic failure, and switch to second-line therapy in a military population in South Africa." Diss., University of Pretoria, 2018. http://hdl.handle.net/2263/64177.

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The study involved retrospective data analysis using statistical methods to re-analyse data collected during a long-term study in a Human Immunodeficiency Virus infected population of South African National Defence Force employees and their dependents, where different parameters related to treatment and disease status of HIV infected patients were collected. This study attempted to identify possible predictors of both early and late occurrence of first-line antiretroviral therapy virologic failure, potential predictors of first-line antiretroviral virologic failure and for switching to second
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2

Court, Richard Gray. "Short term adherence tool predicts failure on second line protease inhibitor-based antiretroviral therapy." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/13801.

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The management of patients failing second line antiretroviral therapy (ART) is a critical area of study considering the increasing numbers of patients on second line regimens, and the expense and poor availability of third line ART. Most patients who experience virologic failure (VF) on second line ART in low-middle income countries fail due to poor adherence rather than antiretroviral resistance. Pharmacy refill is an easily implementable adherence measure which has shown to correlate with viral load monitoring and survival, and has potential over the short term to be used as a simple adheren
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3

Mgosha, Peter Charles. "Barriers to Switching Patients to Second-Line Antiretroviral Treatment Among Clinicians in Tanzania." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3535.

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Poor decision making among clinicians to transferring human immune deficiency virus (HIV) patients into second-line antiretroviral therapy (ART) has led to an increase in morbidity and mortality to people living with HIV (PLHIV). No clear barriers are known for clinicians not switching their patients. This is a descriptive qualitative research aimed to discover obstacles that influence clinicians' decision making to transferring patients into second-line ART despite higher level resistance to first-line ART. The researcher applied a participatory action research framework to solve the identifi
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4

Johnstone, Victoria. "Second-line antiretroviral therapy in a South African treatment programme : exploring determinants of switching and treatment outcomes." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590631.

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5

Namukanja, Phoebe Monalisa-Mayambala. "Adverse effects on second-line highly active antiretroviral therapy (HAART) among HIV infected adults and children treated at Mildway Uganda." Thesis, University of Limpopo (Medunsa Campus), 2011. http://hdl.handle.net/10386/532.

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Thesis (MPH) -- University of Limpopo (Medunsa Campus), 2011.<br>Background Available and affordable second-line antiretroviral treatment regimens are a key component of universal access to treatment and its continuation. However, providing second-line ART is affected by a number of factors including infrastructure, skills and cod competency of available personnel, cost and availability of second-line drugs. Like first-line antiretroviral agents, second-line drugs have also inherent toxicities. While these have been described in adults, few studies reported this in children. Hence, the need
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6

Chen, Mei Hui. "A systematic review of the blood pressure lowering efficacy of diuretics as second-line therapy for primary hypertension." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/12393.

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Context: Although other factors independent of their blood pressure (BP) lowering effect may contribute to the reduction in morbidity and mortality associated with antihypertensive drugs, efficacy of an antihypertensive treatment is gauged by the magnitude of BP reduction. Diuretics are widely prescribed for hypertension not only as first-line monotherapy but also second-line in combination therapy. Therefore, it is essential to determine the effects of diuretics on BP, heart rate (HR) and withdrawals due to adverse effects (WDAEs) when used second-line for hypertension. Objectives: 1) To quan
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7

Meßner, Martina [Verfasser], and Johanna [Akademischer Betreuer] Pachmayr. "Sorafenib resistance of hepatocellular carcinoma : antibiotics second-line to Sorafenib therapy inhibit mitochondrial biogenesis and prevent tumor growth resumption / Martina Meßner ; Betreuer: Johanna Pachmayr." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1216417946/34.

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8

Park, Su-In [Verfasser]. "Gemcitabin und Paclitaxel als Second-Line-Therapie beim fortgeschrittenen oder metastasierten Urothel-Karzinom / Su-In Park." Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1043698728/34.

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9

Kröber, Vinzenz [Verfasser], M. [Akademischer Betreuer] Lommatzsch, K. [Akademischer Betreuer] Jordan, and W. [Akademischer Betreuer] Schütte. "Phase I/II-Studie : Kombinationschemotherapie mit Docetaxel und Pemetrexed in der Second-Line-Therapie bei Patienten mit nichtkleinzelligem Bronchialkarzinom, Stadium IIIB und IV / Vinzenz Kröber. Betreuer: M. Lommatzsch ; K. Jordan ; W. Schütte." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2015. http://d-nb.info/1075492904/34.

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10

Gaspar, Frederico Manuel Gomes Forte Portugal. "Chronic graft-versus-host disease : second line therapy review." Master's thesis, 2017. http://hdl.handle.net/10451/31315.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2017<br>Graft-versus-Host disease (GVHD) is a complication of bone marrow transplant. It has two forms: acute and chronic. In this work we’ll only address the chronic one (cGVHD). cGVHD is a very frequent complication of the transplant (up to 50% of the patients) and a major one, given its high mortality rate, being the main cause of death in these patients, apart from the recurrence of the primary malignancy. Even thought our understanding of GVHD is far from complete, some progresses ar
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11

Rohr, Julia Katherine. "First line antiretroviral treatment failure and second line treatment outcomes among HIV patients in Southern Africa." Thesis, 2015. https://hdl.handle.net/2144/16098.

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Southern Africa has the highest prevalence of HIV worldwide, and South Africa has the highest number of HIV infected people. South Africa and other resource-limited countries provide antiretroviral therapy (ART) for people with HIV, with limited, standardized regimens for first line and second line. Patients who fail first line treatment are put on second line regimens, yet options for third line are very limited. The first study looks at predictors of first line treatment failure in South Africa and develops a predictive model that can estimate absolute risk of treatment failure over 5 ye
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12

Pasipamire, Munyaradzi. "The role of side effects in shifting patients from first line to second line ART at Nthabiseng Clinic in Soweto, Johannesburg." Thesis, 2014.

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The Human Immunodeficiency Virus (HIV) which causes Acquired Immunodeficiency Syndrome (AIDS) has caused a global scare with mainly poor African countries suffering the greatest burden. Treatment of HIV is more of palliation rather than cure such that there is no room for treatment interruption if treatment goals are to be met. Antiretroviral treatment is associated with short term and long term side effects which have the potential to negatively impact on the high levels of adherence to treatment that is required to maintain virological suppression and may eventually lead to development of dr
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13

Pin-HaoChen and 陳品豪. "Comparative effectiveness of second-line initiation of basal insulin therapy versus oral antidiabetic drugs added to metformin therapy among Taiwanese patients with type 2 diabetes." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/nsfs75.

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14

Hladnik, Nejc. "Cost impact of introducing alpha-stim medical technology as a second line treatment for anxiety and depression in Slovenia." Master's thesis, 2020. http://hdl.handle.net/10362/114712.

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Mental disorders affect a substantial proportion of our society and the importance of mental health became an even hotter topic after the Covid-19pandemic resulted in social isolation. For most national health care systems, being understaffed and underfinanced are key defining characteristics. Pharmaceuticals tend to be overprescribed and in depth face-to-face cognitive-behavioural therapy remains reserved mostly for those able to afford it. Alpha-Stim® medical technology is an innovative approach recognized by the American and British national health services a like. Thus, a cost analysis was
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15

Kreitz, Lars. "Retrospektive Studie zum Stellenwert von Fotemustine bei der second-line Therapie des metastasierten malignen Melanoms /." 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=013139404&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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16

Bruweleit, Melanie [Verfasser]. "Molekularbiologische Analyse der Wirkung des Angiogeneseinhibitors SU6668 als Second-line-Therapie im Rahmen einer Studie bei Patienten mit Multiplem Myelom / vorgelegt von Melanie Bruweleit." 2007. http://d-nb.info/983945950/34.

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