Academic literature on the topic 'Secondary immunodeficiency'

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Journal articles on the topic "Secondary immunodeficiency"

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Herman, Katherine E., and Katherine L. Tuttle. "Overview of secondary immunodeficiency." Allergy and Asthma Proceedings 45, no. 5 (2024): 347–54. http://dx.doi.org/10.2500/aap.2024.45.240063.

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In contrast to inborn errors of immunity (IEI), which are inherited disorders of the immune system that predispose to infections, malignancy, atopy, and immune dysregulation, secondary immunodeficiencies and immune dysregulation states (SID) are acquired impairments in immune cell function and/or regulation, and may be transient, reversible, or permanent. SIDs can derive from a variety of medical comorbidities, including protein-losing conditions, malnutrition, malignancy, certain genetic syndromes, prematurity, and chronic infections. Medications, including immunosuppressive and chemotherapeutic drugs, can have profound effects on immunity and biologic agents used in rheumatology, neurology, and hematology/oncology practice are increasingly common causes of SID. Iatrogenic factors, including surgical procedures (thymectomy, splenectomy) can also contribute to SID. A thorough case history, medication review, and laboratory evaluation are necessary to identify the primary driver and determine proper management of SID. Careful consideration should be given to whether a primary IEI could be contributing to autoimmunity, malignancy, and posttreatment complications (e.g., antibody deficiency). SID management consists of addressing the driving condition and/or removing the offending agent if feasible. If SID is suspected to be permanent, then antibiotic prophylaxis, additional immunization, and immunoglobulin replacement should be considered.
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PINCHING, ANTHONY J. "Laboratory Investigation of Secondary Immunodeficiency." Clinics in Immunology and Allergy 5, no. 3 (1985): 469–90. http://dx.doi.org/10.1016/s0260-4639(22)00146-3.

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Chernyshova, L. I. "Secondary immunodeficiency (immunocompromised patient). Lecture." CHILD`S HEALTH 15, no. 6 (2020): 456–60. http://dx.doi.org/10.22141/2224-0551.15.6.2020.215532.

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Browne, Sarah K., and Steven M. Holland. "Immunodeficiency secondary to anticytokine autoantibodies." Current Opinion in Allergy and Clinical Immunology 10, no. 6 (2010): 534–41. http://dx.doi.org/10.1097/aci.0b013e3283402b41.

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Yap, Peng Lee. "Intravenous immunoglobulin for secondary immunodeficiency." Blut 60, no. 1 (1990): 8–14. http://dx.doi.org/10.1007/bf01720196.

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Pogliani, E. M., L. Baldicchi, and E. E. Polli. "Secondary immunodeficiency in lymphoproliferative disorders." Pharmacological Research 26 (September 1992): 84–85. http://dx.doi.org/10.1016/1043-6618(92)90611-e.

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Friman, Vanda, Ola Winqvist, Cecilie Blimark, Petra Langerbeins, Helen Chapel, and Fatima Dhalla. "Secondary immunodeficiency in lymphoproliferative malignancies." Hematological Oncology 34, no. 3 (2016): 121–32. http://dx.doi.org/10.1002/hon.2323.

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Zea-Vera, Andres Felipe. "Tuberculous Meningitis: Immunocompetence, Secondary Immunodeficiency, or Adult Onset Primary Immunodeficiency?" American Journal of Tropical Medicine and Hygiene 101, no. 5 (2019): 1183. http://dx.doi.org/10.4269/ajtmh.19-0535a.

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Babicheva, Lali G., Alexey V. Luntsov, Gulnara N. Khusainova, and Irina V. Poddubnaya. "An interdisciplinary approach to the management of oncohematological patients with immunodeficiency: clinical cases. A review." Journal of Modern Oncology 25, no. 3 (2023): 365–72. http://dx.doi.org/10.26442/18151434.2023.3.202446.

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Immunodeficiency occurs when one or more immune system components do not function properly, resulting in the body's inability to resist mostly infectious agents. Most cases of immunodeficiency in adults are acquired (secondary), but congenital immunodeficiencies are not uncommon. Primary immunodeficiencies are a heterogeneous group of innate immune errors that result in various clinical and laboratory manifestations. In contrast, secondary immunodeficiencies involve an acquired decrease in immune cell count and/or impairment of their function, commonly associated with an antibody level decrease. Secondary immunodeficiency in patients with B-cell hematological malignancies is a common condition attributed to both hematological malignancy and secondary antitumor therapy-related causes. Paradoxically, immunodeficiency, initially attributed to secondary causes, may be due to a previously undiagnosed primary immunodeficiency. Early diagnosis of immunodeficiency and optimization of management strategies with a multidisciplinary approach are critical to providing the most effective specific treatments and reducing the incidence of infection-related complications and mortality. The article addresses clinical practice, recommendations, and problems of immunodeficiency diagnosis and the effectiveness of immunoglobulin replacement therapy illustrated by clinical cases.
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Esenboga, Saliha, Deniz Çagdas, Berna Oguz, et al. "A Rare Cause of Secondary Immunodeficiency." Journal of Pediatric Hematology/Oncology 40, no. 3 (2018): 248–51. http://dx.doi.org/10.1097/mph.0000000000001101.

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Dissertations / Theses on the topic "Secondary immunodeficiency"

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Stubbs, Samuel Christopher. "The virome in primary and secondary immunodeficiency." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277043.

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The afflictions suffered by immunocompromised individuals have historically been attributed to overt infections caused by bacterial and fungal pathogens. For this reason, treatment methods have focused on resolving these infections, with great success in terms of reducing short-term morbidity and mortality rates. This initial success only served to reinforce the dogmatic opinion that to ‘cure’ immunodeficiency, one needs only to resolve and prevent recurrence of bacterial and fungal infections. However, reports of long-term health problems in immunocompromised cohorts suggest that treatment of bacterial and fungal infections alone does not resolve all aspects of the disease, and that viruses may play a greater role than previously expected. This thesis investigates whether viral infections do indeed have a significant impact in the immunocompromised patient. The overall prevalence of blood-borne viral infections in immunocompromised cohorts was determined through the combined use of unbiased, metagenomic sequencing and qPCR. The viral species detected were compared with patient records in order to determine whether there were any correlations between viral presence and patient outcome following treatment. Furthermore, by investigating a cross-section of cohorts with both inherited and acquired immunodeficiences, commonalities and differences could be found in terms of the types of viruses that infect these cohorts and their abundance in patients with different types of immunodeficiency. The findings of this work suggest that a large number of clinically undiagnosed viruses infect immunocompromised patients, however the prevalence of these viruses varies according to the form of immunodeficiency and, to a lesser extent, according to differences between individuals in the same cohort. Importantly, some of the more common viruses detected appear to be correlated with poor patient outcomes such as graft rejection and future infectious complications. Overall, these results suggest that viral infections do indeed play a larger role in the health of immunocompromised patients than has previously been thought although whether this is due to a direct cause or as a consequence is yet to be determined.
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Gregson, James P. "Compartmentalization of human immunodeficiency virus type 1 in the secondary lymphoid tissues /." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd2059.pdf.

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Esteve-Solé, Ana. "Primary and secondary immunodeficiencies of the IL-12/IFN-γ axis". Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663924.

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IL-12/IFN-γ axis is a principal pathway for intramacrophagic pathogens immunity such as leishmania or mycobacteria. Alterations in this axis, being both congenic (causing the primary immunodeficiency Mendelian Susceptibility to Mycobacterial Disease, MSMD) or acquired (treatment with anti-TNF-α drugs) cause susceptibility to this type of microbes. MSMD causes susceptibility mainly to non-pathogenic mycobacteria, salmonella and candida; besides, MSMD- causing mutations have been detected in Mycobacterium tuberculosis and Leishmania patients. On the other hand, the death of an anti-TNF-α in-utero exposed infant after BCG vaccination together with the effect of anti-TNF-α drugs in tuberculosis reactivation in adults and the known tole of TNF-α in B cell maturation reveal the need for an in-depth study of in-utero exposition to anti-TNF-α drugs. With that our hypothesis is that patients with extrapulmonary Mycobacterium tuberculosis infection or visceral leishmaniasis have a primary dysfunction of the IL-12/IFN-γ axis and that exposure to anti-TNF-α antibodies during whole pregnancy in children born to mothers with inflammatory bowel disease affects the normal development of the neonatal immune system, conferring a secondary immunodeficiency, which includes a dysfunction of the IL- 12/IFN-γ axis. Both extrapulmonary tuberculosis (n=23) and visceral leishmaniasis (n=24) patients presented alterations in the IL-12/IFN-γ pathway; however, we did not detect any complete defect. Concretely, the patients with extrapulmonary tuberculosis had a diminished response to IFN-γ while visceral leishmaniasis patients had a diminished production of IFN-g. Genetic study of these patients to unravel mutations causing partial forms of susceptibility to intramacrophagic infections is then needed. Besides, we detected an IL-12Rβ1 defect in a Peruvian patient that was misdiagnosed as multi-resistant tuberculosis, being a disseminated infection by the vaccine strain BCG. After the detection of the genetic defect, the patient was transferred to the National Institute of Health in the USA, where she received the appropriate treatment and the microbiological diagnosis was corrected resulting in the resolution of the infection. This case remarks the fact that suspicion of this forms of immune deficiency and their detection changes the prognostics and outcome of the patient. The study of the effect of anti-TNF-α on the exposed infant immune system (n=7) revealed a T and B cell maturation defect that was corrected at 12 months, normal cell proliferation after mitogen stimulation and normal immunoglobulin production and vaccine response without an increase of severe infections. On the other hand, Treg cell frequency was low in exposed infants, without reaching normalization at 12 months of age. Treg cell frequency in neonates inversely correlated with anti-TNF-α through level in the mother during third trimester of pregnancy and with T cell proliferation after a mild mitogen stimulation. These data with the increased atopia/allergy in the studied infants suggest the need of a long-term follow-up for Treg cells and the advent of immune dysregulation events. Antimycobacterial response was diminished in exposed infants and not totally recovered after washing the drug from the blood in the culture. On the other hand, coinciding with the decrease of the drug levels in blood, the production of IL-12, IFN-γ and TNF-α increased. We conclude that the effects of anti-TNF-α exposure during pregnancy are not permanent and that BCG vaccination in these population should be avoided until, at least, 12 months of age. By last, the transition between the intra- and extra-uterine world is a special life-situation where the immune system plays a major role. We studied it in healthy cord blood donors, with special attention to the IL-12/IFN-γ pathway and B cell compartment, including regulatory B cells (Breg). Breg cells, defined as CD24hiCD38hi B cells, were expanded in cord blood, with capacity to produce IL-10 and to inhibit IL-4 and IFN-γ production by T cells with a similar phenotype when compared with adult Bregs. Besides, response to mycobacterial challenge was diminished. Interestingly, the diminished production of IFN-γ was associated with Breg cell frequency, opening the door to new research studying the role of these cells in different neonatal conditions as well as in cord blood derived stem cell transplantation.<br>Esta tesis explora la vía de IL-12/IFN-g, central en la inmunidad a gérmenes intramacrofágicos, en el contexto de defectos primarios y secundarios. Los defectos primarios en esta vía causan susceptibilidad mendeliana a las micobacterias (MSMD), una inmunodeficiencia primaria que cursa con susceptibilidad a micobacterias no patogénicas principalmente, pero en la que se han descrito pacientes con infecciones por Mycobacterium tuberculosis y con leishmaniasis. En este escenario, la hemos estudiado en pacientes pediátricos con tuberculosis extrapulmonar y leishmaniasis visceral, revelando que no existían defectos completos de la vía, pero sí una alteración funcional en ésta en los dos grupos de pacientes estudiados. Esto reveló la necesidad de un estudio genético exhaustivo para revelar defectos parciales causantes de esta susceptibilidad. El diagnóstico la deficiencia de IL-12Rβ1 en una niña con infección diseminada por BCG, inicialmente diagnosticada como tuberculosis multirresistente, permitió el tratamiento adecuado que llevó a su curación, mostrando la relevancia del diagnóstico temprano del MSMD. Por otro lado, el hecho que se describiera un caso de muerte tras la vacunación con BCG de un neonato expuesto a fármacos anti-TNF-α durante el embarazo hizo pensar que la exposición a estos fármacos durante el embarazo pudiera llevar a defectos en el sistema inmunitario del neonato. Tras su estudio, observamos una inmadurez transitoria del compartimiento B y T; por otro lado, la disminución de la frecuencia de células T reguladoras que no normalizó con la edad juntamente con un aumento de la presencia de atopia o alergia en este grupo. Además, observamos una disminución de la respuesta a micobacterias en los niños expuestos, que mejoró con la edad. Concluimos que los efectos de los niños expuestos a anti-TNF-α durante el embarazo no parecen ser permanentes y que la vacunación con BCG de esta población debe ser evitada hasta los 12 meses de edad. El estudio de sangre de cordón de neonato sano reveló un aumento de la población de células B reguladoras. Además, la frecuencia de estas células se asoció inversamente con la producción de IFN-γ tras el estímulo con micobacterias, que se encontró disminuido en el neonato. Abriendo la puerta a nuevas investigaciones para estudiar su papel en diferentes condiciones del neonato, así como en el trasplante de progenitores hematopoyéticos.
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Gregson, James Peter. "Compartmentalization of HIV-1 in the Secondary Lymphoid Tissues." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd2059.pdf.

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Kumarawansa, W. K. W. S. Boonyong Keiwkarnka. "Safe sex intention towards HIV/AIDS prevention among secondary school students of Khon Pathom province, Thailand /." Abstract, 2006. http://mulinet3.li.mahidol.ac.th/thesis/2549/cd387/4837998.pdf.

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Maleka, Nelisiwe Elma. "An assessment of knowledge of HIV/AIDS amongst secondary school learners of Kwazulu-Natal: an exploratory study of Bergville rural district." Thesis, University of the Western Cape, 2009. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_2481_1363788139.

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<p>The main purpose of the study was to assess and explore the knowledge of HIV/AIDS among secondary learners in rural Bergville district of KwaZulu-Natal. A stratified random sample of 100&nbsp<br>learners was selected from two secondary schools in the area. Data was collected using a questionnaire and interviews were scheduled with the teachers from the selected schools. The&nbsp<br>questionnaire was administered to a sample of 54 learners from school A and 46 from school B. The mean age was 16, with age range from 13-20. The participants were enrolled for grade&nbsp<br>8-12 in both schools. Both qualitative and quantitative data on learners‟ knowledge and perception about HIV/AIDS, condom use and sexual issues including their attitudes towards people living with HIV/AIDS were collected in the questionnaire. Chi-square test was used for statistics purpose to test if the HIV knowledge of learners were associated with gender, culture and&nbsp<br>religion. Qualitative interviews with 9 teachers from both schools were conducted. The main purpose of the interviews was to investigate the management of HIV/AIDS in public schools in rural&nbsp<br>areas. Furthermore, to assess the learner‟s attitude towards HIV/AIDS education provided in schools. The results showed that the learners in Bergville district were more knowledgeable of&nbsp<br>HIV/AIDS through HIV/AIDS education in schools that had limited effect on gender, culture and religion. Quantitative findings presented, indicated no significant differences between those&nbsp<br>learners attending church and cultural activities that offer&nbsp<br>HIV/AIDS awareness programmes and those who do not with regard to the knowledge of HIV/AIDS. However, culture stood out to be associated with one item on the knowledge of whether school children can get HIV/AIDS (p-value = 0.04). On average, the level of knowledge of HIV/AIDS between female and male learners was similar. The major findings on both quantitative and qualitative findings confirmed that learners‟ knowledge levels were very high for modes of transmission and prevention of HIV/AIDS. Despite this knowledge, poor&nbsp<br>behavioural change among learners is a major setback thus increasing high risk of contracting HIV. Adequate knowledge about issues of cure, HIV testing and treatment was of concern in the findings in this study. Furthermore, data from qualitative interviews with the teachers highlighted the lack of multisectoral response to HIV/AIDS in Bergville rural communities which thus&nbsp<br>compromise the effectiveness in management of HIV/AIDS in schools. In summary, the study revealed some of the challenges faced by teachers and learners in regard to HIV/AIDS education.</p>
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Le, Fleur Celeste Catherine. "Comparing the BDI II and the HADS (HADS-D) as a screening tool for depression amongst HIV infected individuals attending a public health clinic." Thesis, University of the Western Cape, 2011. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_2733_1363786537.

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<p>This study utilised secondary data from a larger study that looked at individuals that are already infected by HIV which is entitled Implicative personal dilemmas and cognitive conflicts in health decision making in HIV positive adults and adults with AIDS. The primary aim of the larger study was to examine the cognitive construction of the individual and how they utilised their individual resources to construct who they are and how they perceived the difficulties and challenges that they face and the decisions they make regarding their health. HIV and AIDS is a debilitating disease and it affects millions worldwide. South Africa, presently, has the largest burden of this disease with those between the ages of 15 &ndash<br>49 years of age being most affected. As previously&nbsp<br>mentioned the decisions that individuals make can impact on their health. Decisions to take necessary precautions such as protected sex during sexual intercourse can decrease the&nbsp<br>progression of the disease. Decisions made regarding abstinence of risky behaviour as well as being committed to taking medication could also positively impact health. People living with HIV and AIDS find it&nbsp<br>difficult to adjust to the challenges that this disease presents. Depression is often experienced due to the changes in self image and perception. Studies show that&nbsp<br>females are twice more likely to experience depression than men. There has however been no conclusive evidence showing the reason for this, however, the perception of stress based on&nbsp<br>gender could shed some light on this matter and how these perceptions can increase the likelihood of women being more vulnerable to depression. Due to the limitation of this study, it will&nbsp<br>only look at depression as it relates to HIV and AIDS. Psychological problems such as depression can hamper the adjustment process and the effect of depression is evident in that it can lower the CD 4 + cells. Not only are those&nbsp<br>living with HIV and AIDS affected by depression, but they also have a lifetime prevalence to depression. It is important to have an effective screening tool for depression so that the detection of this&nbsp<br>disease can be made and effective treatment can be implemented to enhance health. The sample consisted of 113 adult participants that have already been diagnosed with HIV and AIDS. The&nbsp<br>primary aim of this study was to compare the Beck&rsquo<br>s Depression Inventory II (BDI II) and the Hospital Anxiety and Depression Scale &ndash<br>(the Depression component) (HADS-D) as a screening tool&nbsp<br>&nbsp<br>for depression. Exploratory Factor Analysis revealed a 5 factor structure which accounted for 60.14 % of the total variance. The HADS yielded one factor accounting for 14.33% of total variance. The BDI II has proven to be more a reliable measure of depression with 0.89 according to the Cronbach&rsquo<br>s Alpha co efficient opposed to 0.375 as per the HADS-D. The secondary aim was to establish&nbsp<br>the sociodemographic and disease profiles of the participants under study. </p>
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Chia-LiangYen and 顏嘉良. "The Role of Leukocyte Signal Transduction on the Pathogenesis of Secondary Immunodeficiency in Obesity." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/77468658186603814938.

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博士<br>國立成功大學<br>基礎醫學研究所<br>102<br>Obesity is a severe health problem worldwide which leads to multiple comorbidities including type 2 diabetes mellitus (DM) and cardiovascular diseases. Inflammation has been found to be an important characteristic of adipose tissue in obese subjects. However, obesity is also associated with compromised immune responses to infections and the impact of obesity on immune function has not been fully understood. To clarify the role of obesity in the immune responses, I investigated the Toll-like receptor (TLR)-induced cytokine secretion by leukocytes from obese and lean subjects. The relationship between insulin-induced intracellular signaling and cytokine production using peripheral blood mononuclear cells (PBMC) and a monocytic cell line THP-1 was also investigated. I found decreased TLR-induced interferon-gamma, interleukin-6 and tumor necrosis factor-alpha secretions and elevated IL-10 secretion by leukocytes from obese subjects when compared with those in lean controls. PBMCs from obese subjects showed enhanced basal Akt and glycogen synthase kinase 3β (GSK-3β) phosphorylation which did not further increased with insulin and lipopolysaccharide (LPS) stimulation. I also found that LPS-induced IκB degradation was inhibited in PBMCs from obese subjects. By using THP-1 cells with GSK-3β knockdown or cells treated with hyperinsulinemic and high fatty acid conditions, I found that LPS-induced NF-κB activation was inhibited and cAMP response element-binding protein (CREB) activation was enhanced. I also found that bariatric surgery corrected the abnormal TLR-induced cytokine secretions in obese subjects. Moreover, type 2 DM, which may be developed from obesity, also showed abnormal TLR-induced cytokine secretions. These findings indicated that GSK-3β is important in the regulation of NF-κB and CREB activation in leukocytes under the metabolic condition of obesity. Our study hence reveals a key mechanism through which metabolic abnormalities, even before the onset of type 2 DM, compromise leukocyte functions in people with obesity.
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McBride, Michael Scott. "Cis-elements and associated secondary structure important for human immunodeficiency virus type 1 RNA encapsidation." 1996. http://catalog.hathitrust.org/api/volumes/oclc/36850625.html.

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Thesis (Ph. D.)--University of Wisconsin--Madison, 1996.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 184-226).
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Hyrcza, Martin Dominik. "Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection." Thesis, 2009. http://hdl.handle.net/1807/26459.

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Human immunodeficiency virus infection is a chronic condition causing significant changes in the immune system, which are reflected in the altered gene expression patterns of the immune cells. By studying these patterns through gene expression profiling it is possible to describe not only the current states the cells are in, but also to extrapolate the proximal signals that resulted in the observed patterns. In the studies described herein, we have applied this approach to better understand the alterations in the immune function that occur in HIV infection. First, we have obtained transcriptional profiles of CD4+ and CD8+ T cells from patients in early infection, in chronic infection, and in non-progressive infection, and we compared these profiles to each other and to the profiles from uninfected donors. The analyses of the profiles revealed no discernable changes in the T cells of the non-progressive patients when compared to the uninfected individuals. On the other hand, T cells from patients with progressive infection, both early and late, showed patterns characteristic of type I interferon (IFN) exposure. We next examined experimentally the possible proximal causes of the observed transcriptional profiles. We analyzed the gene expression patterns induced by TGFβ, 13 type I interferons, as well as recombinant HIV Tat protein, in T cells and peripheral blood mononuclear cells. The TGFβ responses were inconsistent with the transcriptional profiles seen in HIV-infected patients, whereas both type I IFNs and HIV Tat induced genes in patterns consistent with those seen in patients. In fact, the thirteen IFN-induced patterns were indistinguishable from each other. Tat treatments induced interferon-stimulated genes (ISGs) as well as other genes and the response was not dependent on the presence of plasmacytoid dendritic cells (pDCs), suggesting monocytes as the possible source of the interferon response. In the last study, we examined the responses of plasmacytoid dendritic cells (pDCs) to HIV and other stimuli in healthy and HIV-infected subjects. We observed induction of IFN genes in pDCs of all subjects in response to influenza virus and TLR7 agonist imiquimod, but not to HIV virus. In summary, HIV infection results in chronic induction of type I IFN response in cells of the immune system. The source of this response is likely to be type I IFNs produced by monocytes/macrophages rather than plasmacytoid cells. The monocytic production of type I IFN may be a Tat-dependent response.
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Books on the topic "Secondary immunodeficiency"

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Bernstein, Jonathan A., ed. Primary and Secondary Immunodeficiency. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57157-3.

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M, Eibl Martha, ed. Symposium in Immunology III: Humoral immunodeficiencies (primary and secondary). Springer-Verlag, 1994.

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Török, M. Estée, Fiona J. Cooke, and Ed Moran. Immunodeficiency and HIV. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199671328.003.0024.

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This chapter covers primary and secondary immunodeficiency, antibody deficiency syndromes, selective T-cell deficiency, infections in asplenic patients and transplant recipients, neutropenic sepsis, HIV epidemiology, natural history, and classification, initial evaluation of the HIV patient, skin, oral, cardiovascular, neurological, and pulmonary complications, HIV gastrointestinal, liver, and kidney disease, HIV infection and malignancy, as well as HIV prevention.
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Bernstein, Jonathan A. Primary and Secondary Immunodeficiency: A Case-Based Guide to Evaluation and Management. Springer International Publishing AG, 2022.

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Bernstein, Jonathan A. Primary and Secondary Immunodeficiency: A Case-Based Guide to Evaluation and Management. Springer International Publishing AG, 2021.

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Bhagani, Dr Sanjay, Dr Nicholas Easom, Dr Sanjay Bhagani, Dr Nicholas Easom, and Dr Nicholas Easom. Immunocompromised patients, including HIV-positive patients. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199565979.003.00013.

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Chapter 13 discusses immunocompromised patients, including HIV-positive patients, HIV and other causes of immunodeficiency, infections in the HIV-infected patient, post-exposure prophylaxis (PEP) for prevention of HIV infection, non-HIV causes of immunodeficiency, secondary immunodeficiency in malignancy or post-chemotherapy, immune dysfunction and systemic illness, solid organ transplant, and immunosuppressive therapy.
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Misbah, Siraj. Clinical features and diagnosis of immunological disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0294.

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Immunological disease can be broadly defined as a spectrum of problems ranging from failure of the immune system (primary or secondary immunodeficiency) to the clinical consequences of an overzealous immune system, manifesting clinically as autoimmunity, allergy, or, rarely, as an autoinflammatory syndrome. This chapter addresses the clinical features and diagnosis of immunological disease.
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Bhole, Malini. Neutrophil abnormalities. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0295.

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Neutrophils are an important component of the innate immune system, forming the first line of defence against bacterial invasion. Abnormalities in either neutrophil numbers or function lead to immunodeficiency disorders affecting the innate immune system, with a predisposition towards developing serious and often life-threatening infections. Alterations in neutrophil numbers and function may also be noted secondary to systemic diseases, where they may act as markers for ongoing disease processes. Most of the primary neutrophil disorders discussed in this chapter will present in childhood. In adults, acquired neutropenia is the commonest neutrophil abnormality encountered in clinical practice, although, rarely, some primary neutrophil defects may present.
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Book chapters on the topic "Secondary immunodeficiency"

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Gooch, Jan W. "Secondary Immunodeficiency Disease." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_14755.

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Perez, Elena E. "Clinical Presentation of Immunodeficiency, Secondary Immunodeficiency." In Encyclopedia of Medical Immunology. Springer New York, 2020. http://dx.doi.org/10.1007/978-1-4614-8678-7_70.

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Perez, Elena E. "Clinical Presentation of Immunodeficiency, Secondary Immunodeficiency." In Encyclopedia of Medical Immunology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4614-9209-2_70-1.

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Galant-Swafford, Jessica, and Bob Geng. "Severe Combined Immunodeficiency." In Primary and Secondary Immunodeficiency. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57157-3_8.

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Tamayev, Robert, and Jenny Shliozberg. "Selective Isotype Immunodeficiency." In Primary and Secondary Immunodeficiency. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57157-3_6.

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Sokol, Kristin C. "Transient Immunodeficiency of Infancy." In Primary and Secondary Immunodeficiency. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57157-3_5.

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Afinogenova, Yuliya, and Joel P. Brooks. "Idiopathic CD4 Lymphopenia." In Primary and Secondary Immunodeficiency. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57157-3_9.

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Gans, Melissa D., and Rachel Eisenberg. "Immune Dysregulation Leading to Autoimmunity." In Primary and Secondary Immunodeficiency. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57157-3_14.

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Lehman, Heather K., and Parteet Sandhu. "Common Variable Immunodeficiency, Hypogammaglobulinemia, and Specific Antibody Deficiency." In Primary and Secondary Immunodeficiency. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57157-3_2.

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Al-Shaikhly, Taha. "Hyper IgE Syndrome." In Primary and Secondary Immunodeficiency. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57157-3_10.

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Conference papers on the topic "Secondary immunodeficiency"

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Razi, Fachrur, Musofa Rusli, Muhammad Vitanata Arfijanto, Bramantono, Usman Hadi, and Erwin Astha Triyono. "Varicella-Infected Acquired Immunodeficiency Syndrome Patient with Secondary Infection." In International Meeting on Regenerative Medicine. SCITEPRESS - Science and Technology Publications, 2017. http://dx.doi.org/10.5220/0007322804400447.

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Shapovalova, Irina Aleksandrovna, and Svetlana Evgen'evna Yakimovich. "ASSESSMENT OF THE EFFECTIVENESS OF PHYTOTHERAPY FOR SECONDARY IMMUNODEFICIENCY CONDITIONS." In Themed collection of papers from Foreign International Scientific Conference «Modern research on the way to a new scientific revolution». by HNRI «National development» in cooperation with AFP (Puerto Cabezas, Nicaragua). November 2024. – Havana (Cuba). Crossref, 2025. https://doi.org/10.37539/241128.2024.89.11.017.

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Secondary immunodeficiency states are widespread in people living in environmentally unfavourable regions. Such patients are characterised by uniform changes in immunological parameters, which are imbalanced in the subpopulation of T-lymphocytes. The use of phytopreparations leads to normalisation of immunological indices and subsequent reduction in the frequency of recurrent acute respiratory viral infections.
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Oliveira, Vitor Antonio de Angeli, Vanessa Posener de Andrade, Carolina Teixeira Cidon, et al. "Acquired immunodeficiency secondary to rituximab treatment in Systemic Lupus Erythematosus." In XXXIX Congresso Brasileiro de Reumatologia. Sociedade Brasileiro de Reumatologia, 2022. http://dx.doi.org/10.47660/cbr.2022.1973.

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Dzhuvalyakov, Pavel, Dmitry Bogomolov, and Julia Zbrueva. "The relevance of the question of the study of a corpse with suspected HIV." In Issues of determining the severity of harm caused to human health as a result of the impact of a biological factor. Publishing Center RIOR, 2020. http://dx.doi.org/10.29039/conferencearticle_5fdcb03a696517.02994233.

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HIV infection is a disease caused by the human immunodeficiency virus, characterized by acquired immunodeficiency syndrome, which contributes to the occurrence of secondary infections and malignant tumors due to deep inhibition of the body's protective properties. Today, the world is experiencing a pandemic of HIV infection, the incidence of the world's population, especially in Eastern Europe, is growing steadily.
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Zhang, J., M. Pan, W. Zeng, Y. Qiu, S. Tang, and X. Feng. "Talaromycosis-Associated Secondary Hemophagocytic Lymphohistiocytosis in Nine Human Immunodeficiency Virus-Negative Patients: A Multicenter Retrospective Study." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7605.

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