Academic literature on the topic 'Secretomotor neurons'

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Journal articles on the topic "Secretomotor neurons"

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Reed, David E., and Stephen Vanner. "Mucosal stimulation activates secretomotor neurons via long myenteric pathways in guinea pig ileum." American Journal of Physiology-Gastrointestinal and Liver Physiology 292, no. 2 (2007): G608—G614. http://dx.doi.org/10.1152/ajpgi.00364.2006.

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This study examined whether mucosal stimulation activates long secretomotor neural reflexes and, if so, how they are organized. The submucosa of in vitro full thickness guinea pig ileal preparations was exposed in the distal portion and intracellular recordings were obtained from electrophysiologically identified secretomotor neurons. Axons in the intact mucosa of the oral segment were stimulated by a large bipolar stimulating electrode. In control preparations, a single stimulus pulse evoked a fast excitatory postsynaptic potential (EPSP) in 86% of neurons located 0.7–1.0 cm anal to the stimu
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Li, Chen, та John P. Horn. "Differential Inhibition of Ca2+ Channels by α2-Adrenoceptors in Three Functional Subclasses of Rat Sympathetic Neurons". Journal of Neurophysiology 100, № 6 (2008): 3055–63. http://dx.doi.org/10.1152/jn.90590.2008.

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A comparison of identified sympathetic neurons in the isolated intact superior cervical ganglion revealed that secretomotor, pilomotor, and vasoconstrictor cells differ in their action potential mechanisms and in their postsynaptic α2-adrenergic responses to 10 μM norepinephrine (NE). In normal saline, the half-width of the spike afterhyperpolarization (AHP) in secretomotor neurons (103.5 ± 6.2 ms) was twofold that recorded in vasoconstrictor neurons (47.7 ± 2.9 ms) and 1.5-fold that in pilomotor neurons (71.4 ± 10.3 ms). Bath-applied NE reversibly inhibited the action potential repolarization
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Foong, Jaime Pei Pei, Laura J. Parry, Rachel M. Gwynne, and Joel C. Bornstein. "5-HT1A, SST1, and SST2receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum." American Journal of Physiology-Gastrointestinal and Liver Physiology 298, no. 3 (2010): G384—G394. http://dx.doi.org/10.1152/ajpgi.00438.2009.

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Vasoactive intestinal peptide (VIP) immunoreactive neurons are important secretomotor neurons in the submucous plexus. They are the only submucosal neurons to receive inhibitory inputs and exhibit both noradrenergic and nonadrenergic inhibitory synaptic potentials (IPSPs). The former are mediated by α2-adrenoceptors, but the receptors mediating the latter have not been identified. We used standard intracellular recording, RT-PCR, and confocal microscopy to test whether 5-HT1A, SST1, and/or SST2receptors mediate nonadrenergic IPSPs in VIP submucosal neurons in guinea pig ileum in vitro. The spe
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Kuwahara, Atsukazu, Yuko Kuwahara, Ikuo Kato, et al. "Xenin-25 induces anion secretion by activating noncholinergic secretomotor neurons in the rat ileum." American Journal of Physiology-Gastrointestinal and Liver Physiology 316, no. 6 (2019): G785—G796. http://dx.doi.org/10.1152/ajpgi.00333.2018.

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Xenin-25 is a neurotensin-like peptide that is secreted by enteroendocrine cells in the small intestine. Xenin-8 is reported to augment duodenal anion secretion by activating afferent neural pathways. The intrinsic neuronal circuits mediating the xenin-25-induced anion secretion were characterized using the Ussing-chambered, mucosa-submucosa preparation from the rat ileum. Serosal application of xenin-25 increased the short-circuit current in a concentration-dependent manner. The responses were abolished by the combination of Cl−-free and [Formula: see text]-free solutions. The responses were
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Goldhill, J. M., R. Burakoff, V. Donovan, K. Rose, and W. H. Percy. "Defective modulation of colonic secretomotor neurons in a rabbit model of colitis." American Journal of Physiology-Gastrointestinal and Liver Physiology 264, no. 4 (1993): G671—G677. http://dx.doi.org/10.1152/ajpgi.1993.264.4.g671.

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The present in vitro study was conducted to investigate possible alterations in the control of colonic electrolyte transport in an experimental model of colitis. Intrarectal administration of trinitrobenzenesulfonic acid induced a colitis-like inflammation in the rabbit distal colon. Responses to amiloride and residual short-circuit current after this treatment were unchanged, suggesting that the absorptive and secretory mechanisms remained intact. Electrical field stimulation and vasoactive intestinal polypeptide, a candidate secretomotor neurotransmitter, both elicited similar responses in c
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Vanner, S., and W. K. MacNaughton. "Capsaicin-sensitive afferent nerves activate submucosal secretomotor neurons in guinea pig ileum." American Journal of Physiology-Gastrointestinal and Liver Physiology 269, no. 2 (1995): G203—G209. http://dx.doi.org/10.1152/ajpgi.1995.269.2.g203.

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This study examined whether capsaicin-sensitive sensory nerves regulate intestinal ion transport using both Ussing chamber and intracellular recording techniques in in vitro submucosal preparations from the guinea pig ileum. In Ussing chamber studies, serosal application of capsaicin (20 nM-20 microM) evoked a biphasic dose-dependent increase in short-circuit current (Isc) (maximal effective concentration 200 nM and 2 microM, respectively). In chloride-free buffer, capsaicin responses were significantly reduced. Capsaicin evoked little or no response when extrinsic sensory nerve fibers had bee
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Lay, Joslyn, Simona E. Carbone, Jesse J. DiCello, Nigel W. Bunnett, Meritxell Canals та Daniel P. Poole. "Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig". American Journal of Physiology-Gastrointestinal and Liver Physiology 311, № 2 (2016): G252—G266. http://dx.doi.org/10.1152/ajpgi.00184.2016.

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The μ-opioid receptor (MOR) is a major regulator of gastrointestinal motility and secretion and mediates opiate-induced bowel dysfunction. Although MOR is of physiological and therapeutic importance to gut function, the cellular and subcellular distribution and regulation of MOR within the enteric nervous system are largely undefined. Herein, we defined the neurochemical coding of MOR-expressing neurons in the guinea pig gut and examined the effects of opioids on MOR trafficking and regulation. MOR expression was restricted to subsets of enteric neurons. In the stomach MOR was mainly localized
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MacNaughton, W., B. Moore, and S. Vanner. "Cellular pathways mediating tachykinin-evoked secretomotor responses in guinea pig ileum." American Journal of Physiology-Gastrointestinal and Liver Physiology 273, no. 5 (1997): G1127—G1134. http://dx.doi.org/10.1152/ajpgi.1997.273.5.g1127.

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This study characterized tachykinin-evoked secretomotor responses in in vitro submucosal and mucosal-submucosal preparations of the guinea pig ileum using combined intracellular and Ussing chamber recording techniques. Superfusion of endogenous tachykinins substance P (SP), neurokinin A (NKA), and neurokinin B depolarized single submucosal neurons and evoked increased short-circuit current ( I sc) responses in Ussing chamber preparations. The NK1-receptor agonist [Sar9,Met(O2)11]SP [50% effective concentration (EC50) = 2 nM] depolarized all submucosal neurons examined. The NK3-receptor agonist
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MacNaughton, Wallace K., Marja D. Van Sickle, Catherine M. Keenan, Kelly Cushing, Ken Mackie, and Keith A. Sharkey. "Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves." American Journal of Physiology-Gastrointestinal and Liver Physiology 286, no. 5 (2004): G863—G871. http://dx.doi.org/10.1152/ajpgi.00482.2003.

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We investigated the distribution and function of cannabinoid (CB)1receptors in the submucosal plexus of the guinea pig ileum. CB1receptors were found on both types of submucosal secretomotor neurons, colocalizing with VIP and neuropeptide Y (NPY), the noncholinergic and cholinergic secretomotor neurons, respectively. CB1receptors colocalized with transient receptor potential vanilloid-1 receptors on paravascular nerves and fibers in the submucosal plexus. In the submucosal ganglia, these nerves were preferentially localized at the periphery of the ganglia. In denervated ileal segments, CB1rece
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Kullmann, Paul H. M., and John P. Horn. "Vasomotor sympathetic neurons are more excitable than secretomotor sympathetic neurons in bullfrog paravertebral ganglia." Autonomic Neuroscience 155, no. 1-2 (2010): 19–24. http://dx.doi.org/10.1016/j.autneu.2009.12.009.

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Dissertations / Theses on the topic "Secretomotor neurons"

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Hu, Hong-Zhen. "Purinergic neurogenic intestinal mucosal secretion." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1100028634.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Document formatted into pages; contains 171 p. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Nov. 10.
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Book chapters on the topic "Secretomotor neurons"

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Atkinson, Martin E. "The autonomic nervous system." In Anatomy for Dental Students. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199234462.003.0025.

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A large part of the nervous system is dedicated to the control of the internal viscera and their functions. Much of the activity of these organs is controlled reflexly at the brainstem level, e.g. the cardiovascular and respiratory centres (the vital centres) in the reticular formation of the medulla controlling cardiac and respiratory activity. There are also centres in the cerebrum, notably the hypothalamus in the diencephalon. Somatic and visceral functions are closely integrated at these higher levels; think of the effect that emotional factors or somatic stimulation can have on heart rate, blood pressure, and gastrointestinal activity when we are nervous or are in pain. The nerves involved in these activities are described as visceral sensory or visceral motor nerves because they control visceral function; this distinguishes them from somatic sensory nerves from peripheral receptors and somatic motor nerves controlling voluntary function. Visceral motor neurons innervate smooth muscle and secretory cells of the gastrointestinal and respiratory systems, the smooth and cardiac muscle of the cardiovascular system, the sweat glands and arrector pili muscles of the skin, and the muscles of the ciliary body and iris of the eyeball. In many cases, there is a dual supply from the sympathetic and parasympathetic divisions of the autonomic nervous system. In both divisions of the autonomic nervous system, there is a sequence of two neurons between the CNS and the effector organ which synapse in peripheral autonomic ganglia. The neurons from the CNS to the synapse in the ganglion are the preganglionic neurons and those from the ganglia to the effector organs are the postganglionic neurons. The enteric plexus is a third set of neurons interposed between the post-ganglionic neurons and the effector cells in the gastrointestinal tract. Figure 17.1 compares the general arrangement of the sympathetic and parasympathetic nervous system. The cell bodies of sympathetic visceral preganglionic motor neurons are located in the intermediolateral horns of the thoracic and upper lumbar segments of the spinal cord while those of the parasympathetic visceral preganglionic (secretomotor) neurons are in the nuclei of four of the cranial nerves and the sacral segments of the spinal cord.
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