Academic literature on the topic 'Secretory leukocyte proteinase inhibitor (SLPI)'

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Journal articles on the topic "Secretory leukocyte proteinase inhibitor (SLPI)"

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van Wetering, Sandra, Abraham C. van der Linden, Marianne A. J. A. van Sterkenburg, et al. "Regulation of SLPI and elafin release from bronchial epithelial cells by neutrophil defensins." American Journal of Physiology-Lung Cellular and Molecular Physiology 278, no. 1 (2000): L51—L58. http://dx.doi.org/10.1152/ajplung.2000.278.1.l51.

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Secretory leukocyte proteinase inhibitor (SLPI) is a serine proteinase inhibitor that is produced locally in the lung by cells of the submucosal bronchial glands and by nonciliated epithelial cells. Its main function appears to be the inhibition of neutrophil elastase (NE). Recently, NE was found to enhance SLPI mRNA levels while decreasing SLPI protein release in airway epithelial cells. Furthermore, glucocorticoids were shown to increase both constitutive and NE-induced SLPI mRNA levels. In addition to NE, stimulated neutrophils also release α-defensins. Defensins are small, antimicrobial po
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Chuluyan, Eduardo, Nella Ambrosi, Nicolas Fraunhoffer, et al. "Secretory leukocyte proteinase inhibitor: A key player in the dialogue between the tumor and its microenvironment in pancreatic cancer patients." Journal of Clinical Oncology 40, no. 4_suppl (2022): 592. http://dx.doi.org/10.1200/jco.2022.40.4_suppl.592.

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592 Background: Secretory leukocyte proteinase inhibitor (SLPI) is a non-glycosylated pleiotropic protein with anti-protease, microbicidal, healing, anti-inflammatory and immunomodulatory activity. Previous studies have shown that SLPI is associated with pancreatic tumor progression by promoting cancer cell survival and proliferation. However, SLPI can also act on the tumor microenvironment to affect the local immune response. In the present work we evaluate the role of SLPI in patients with pancreatic cancer and its activity as a tumor escape factor from the immune response. Methods: Serum le
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Jiménez-Vega, Florinda, and Francisco Vargas-Albores. "A secretory leukocyte proteinase inhibitor (SLPI)-like protein from Litopenaeus vannamei haemocytes." Fish & Shellfish Immunology 23, no. 5 (2007): 1119–26. http://dx.doi.org/10.1016/j.fsi.2007.06.006.

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Fernie-King, Barbara A., David J. Seilly, Alexandra Davies, and Peter J. Lachmann. "Streptococcal Inhibitor of Complement Inhibits Two Additional Components of the Mucosal Innate Immune System: Secretory Leukocyte Proteinase Inhibitor and Lysozyme." Infection and Immunity 70, no. 9 (2002): 4908–16. http://dx.doi.org/10.1128/iai.70.9.4908-4916.2002.

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ABSTRACT Streptococcal inhibitor of complement (SIC) is a 31-kDa extracellular protein of a few, very virulent, strains of Streptococcus pyogenes (particularly M1 strains). It is secreted in large quantities (about 5 mg/liter) and inhibits complement lysis by blocking the membrane insertion site on C5b67. We describe investigations into the interaction of SIC with three further major components of the innate immune system found in airway surface liquid, namely, secretory leukocyte proteinase inhibitor (SLPI), lysozyme, and lactoferrin. Enzyme-linked immunosorbent assays showed that SIC binds t
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NANDEDKAR, S. "The effect of secretory leukocyte proteinase inhibitor (SLPI) in a murine model of asthma*1." Journal of Allergy and Clinical Immunology 113, no. 2 (2004): S220. http://dx.doi.org/10.1016/j.jaci.2004.01.244.

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Moreau, Thierry, Kévin Baranger, Sébastien Dadé, Sandrine Dallet-Choisy, Nicolas Guyot, and Marie-Louise Zani. "Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family." Biochimie 90, no. 2 (2008): 284–95. http://dx.doi.org/10.1016/j.biochi.2007.09.007.

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Xie, WenTing, Han Zhang, ShanShan Qin, et al. "The expression and clinical significance of secretory leukocyte proteinase inhibitor (SLPI) in mammary carcinoma using bioinformatics analysis." Gene 720 (December 2019): 144088. http://dx.doi.org/10.1016/j.gene.2019.144088.

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Skott, P., E. Lucht, M. Ehnlund, and E. Björling. "Inhibitory function of secretory leukocyte proteinase inhibitor (SLPI) in human saliva is HIV-1 specific and varies with virus tropism." Oral Diseases 8, no. 3 (2002): 160–67. http://dx.doi.org/10.1034/j.1601-0825.2002.01807.x.

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Sakunwattana, Taksaorn, Phattarunda Jaree, Vichien Rimphanitchayakit, Anchalee Tassanakajon, and Sirinit Tharntada. "Antibacterial and antiproteinase activities of a double whey acidic protein domain-containing protein from Penaeus vannamei Boone, 1931 (Decapoda, Penaeidae)." Crustaceana 93, no. 1 (2020): 51–69. http://dx.doi.org/10.1163/15685403-00003962.

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Abstract Double whey acidic protein domain-containing proteins (DWDs) or secretory leukocyte protease inhibitor (SLPI)-like proteins, have been identified in many species of Crustacea. The PvDWD1 from Penaeus vannamei was the first SLPI-like protein identified in a crustacean. Herein, we report that the expression of PvDWD1 was up-regulated at 6 h after acute hepatopancreatic necrosis disease (AHPND)-causing Vibrio parahaemolyticus (VPAHPND) challenge. Similarly, after a different stress other than bacterial infection, the chronic non-lethal heat shock (NLHS) induction, the expression of the P
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Sallenave, J. M., J. Shulmann, J. Crossley, M. Jordana, and J. Gauldie. "Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes." American Journal of Respiratory Cell and Molecular Biology 11, no. 6 (1994): 733–41. http://dx.doi.org/10.1165/ajrcmb.11.6.7946401.

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Dissertations / Theses on the topic "Secretory leukocyte proteinase inhibitor (SLPI)"

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Toulson, Gregory. "The role of Secretory Leukocyte Protease Inhibitor (SLPI) in progranulin regulation and neurodegeneration." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-secretory-leukocyte-protease-inhibitor-slpi-in-progranulin-regulation-and-neurodegeneration(bded6e44-c72e-4d21-8133-a16652204a9e).html.

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Frontotemporal lobar degeneration (FTLD) is an early onset neurodegenerative disorder which selectively destroys frontal and temporal cortical neurones. The resulting damage leads to a range of language and behavioural deficits, however, episodic memory is generally maintained. Around 10% of FTLD cases are caused by progranulin gene mutations that lead to haploinsufficiency and reduced expression of progranulin. Secretory leukocyte protease inhibitor (SLPI) has been shown to have a key protective effect over progranulin, inhibiting enzymatic cleavage by neutrophil elastase. Previous work demon
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Hebebrand, Lena Charlotte [Verfasser]. "Humane Papillomvirus-Infektion in Kopf- und Halskarzinomen: die Rolle der Antileukoproteinase „Secretory Leukocyte Protease Inhibitor“ (SLPI) / Lena Charlotte Hebebrand." Kiel : Universitätsbibliothek Kiel, 2013. http://d-nb.info/103306243X/34.

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Möller, Paul [Verfasser]. "Humane Papillomvirus-Infektionen in Karzinomen des Kopf- und Halsbereiches : die Rolle der Antileukoproteinase „secretory leukocyte protease inhibitor“ (SLPI) in Tabakrauch-induzierten, HPV-unabhängigen Plattenepithelkarzinomen / Paul Möller." Kiel : Universitätsbibliothek Kiel, 2015. http://d-nb.info/1073150666/34.

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Roghanian, Ali. "Modulation of dendritic cells by human neutrophil elastase and its inhibitors in pulmonary inflammation." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/4398.

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Dendritic cells (DC) are sentinels of the immune system that display an extraordinary capacity to present antigen to naïve T cells and initiate immune responses. DCs are distributed throughout the lungs in the conducting airways of the tracheobronchial tree and in the parenchymal lung, and play a pivotal role in controlling the immune response to inhaled antigens. The respiratory surface is continually exposed to potentially injurious particulates and pathogenic organisms, to which tightly regulated innate and adaptive immunological responses are made. The airways are usually sterile in healt
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Zabiegło, Katarzyna. "SLPI jako czynnik regulujący tworzenie i funkcje sieci neutrofilowych." Praca doktorska, 2015. http://ruj.uj.edu.pl/xmlui/handle/item/43076.

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Neelima, P. S. "Molecular Approaches To understand Cellular Differentiation - A Study Using BeWo Choriocarcinoma Cells." Thesis, 2007. https://etd.iisc.ac.in/handle/2005/687.

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Cellular differentiation is a complex but fascinating process in all multicellular organisms. Differentiation can involve changes in numerous aspects of cell physiology; size, shape, polarity, metabolic activity, responsiveness to signals, and changes in gene expression profiles. These changes form the basis for differentiation to occur. The human hemochorial placenta is an intricate apposition of fetal and maternal tissues that is strategically juxtaposed at the interface, with its widespread ‘villous’ or tree-like projections, directly in contact with maternal blood. It is therefore, ideal
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Neelima, P. S. "Molecular Approaches To understand Cellular Differentiation - A Study Using BeWo Choriocarcinoma Cells." Thesis, 2007. http://hdl.handle.net/2005/687.

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Cellular differentiation is a complex but fascinating process in all multicellular organisms. Differentiation can involve changes in numerous aspects of cell physiology; size, shape, polarity, metabolic activity, responsiveness to signals, and changes in gene expression profiles. These changes form the basis for differentiation to occur. The human hemochorial placenta is an intricate apposition of fetal and maternal tissues that is strategically juxtaposed at the interface, with its widespread ‘villous’ or tree-like projections, directly in contact with maternal blood. It is therefore, ideall
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Book chapters on the topic "Secretory leukocyte proteinase inhibitor (SLPI)"

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Hannila, Sari S. "Secretory Leukocyte Protease Inhibitor (SLPI)." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101834.

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Hannila, Sari S. "Secretory Leukocyte Protease Inhibitor (SLPI)." In Encyclopedia of Signaling Molecules. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101834-1.

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"Secretory Leukocyte Peptidase/Proteinase Inhibitor." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_103437.

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Conference papers on the topic "Secretory leukocyte proteinase inhibitor (SLPI)"

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Martin, Brennan D., Melissa D. Adams, Elizabeth A. Horlick, Patricia G. Murphy, and Douglas P. Malinowski. "Abstract 4620: The Secretory Leukocyte Peptidase Inhibitor (SLPI) is differentially expressed in normal ovary and ovarian tumor tissues." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4620.

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Glasgow, Arlene, Nicolas Camper, Megan Osbourn, et al. "LSC Abstract – A functional variant of secretory leukocyte protease inhibitor (SLPI) with improved anti-inflammatory activity against pulmonary infection." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa5107.

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Masterson, Claire H., Daniel P. O'Toole, and John G. Laffey. "Over Expression Of Secretory Leukocyte Protease Inhibitor (SLPI) And Glutathione Peroxidase-3 (GPX3) Attenuate Inflammation And Oxidant-Mediated Pulmonary Epithelial Injury." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2650.

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Perea, Lídia, Emma Johnson, Carlos Fernandez, et al. "Treatment with the dipeptidyl peptidase-1 inhibitor brensocatib increases the antimicrobial peptide secretory leukocyte peptidase inhibitor (SLPI) in patients with bronchiectasis: results from the WILLOW trial." In ERS International Congress 2023 abstracts. European Respiratory Society, 2023. http://dx.doi.org/10.1183/13993003.congress-2023.oa1459.

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Quabius, ES, D. Haaser, J. Loehr, et al. "Die Rolle der Antileukoproteinase secretory leukocyte protease inhibitor (SLPI) in Karzinomen der Vulva in Relation zu HPV-Infektion und dem Rauchverhalten der Patienten." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640136.

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Quabius, ES, D. Haaser, J. Loehr, et al. "The role of the antileukoprotease secretory leukocyte protease inhibitor (SLPI) in squamous cell carcinoma of the vulva in relation to HPV-infection and smoking habit of the patients." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640137.

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