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Journal articles on the topic 'Securigera securidaca'

Author: Grafiati

Published: 4 June 2025

Last updated: 15 July 2025

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1

Abdelbagi, Mohamed E. M., Ghassab M. Al-Mazaideh, Adil Elhag Ahmed, et al. "Drug Formulation of Securigera securidaca Seed Extracts." Processes 11, no. 7 (2023): 1955. http://dx.doi.org/10.3390/pr11071955.

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S. securidaca seeds are reported to treat a variety of diseases; they contain multiple antidiabetic constituents and are widely used as anti-hyperglycemic, antibacterial, as well as anti-hyperlipidemic agents. The present work aimed to propose tablet formulations containing extracts of S. securidaca seeds in an attempt to obtain antibacterial and anti-hyperglycemic formulations with a more efficient oral hypoglycemic impact, limited side effects, and higher patient compliance for the first time, resulting in multiple benefits. Tablet formulations were created by encapsulating granules from S.

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2

Azadbakht, Mohammad, Ahmadi Seyyedeh Atiyeh, and Nematollah Ahangar. "Antidiabetic Activity of Aqueous Seed Extract of Securigera securidaca in Streptozotocin Induced Diabetic Rats." Journal of Advances in Medical and Biomedical Research 27, no. 123 (2019): 16–22. https://doi.org/10.30699/jambs.27.123.16.

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<strong>Background & Objective:</strong> <em>Securigera securidaca </em>is a medicinal plant used in Persian folk medicine to decrease blood sugar. Nevertheless, there is some controversy about its effects. The current study investigated the hypoglycemic activity of the aqueous seed extract of <em>S. securidaca</em>. <strong>Materials & Methods:</strong> Sixty mature male Charles-River rats were categorized and divided randomly into 10 groups with two timeframes (7 and 14 days). To induce diabetes, rats were injected intraperitoneally with 7 mg/0.5 mL streptozotocin

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3

Tofighi, Zahra, Parina Asgharian, Saied Goodarzi, Abbas Hadjiakhoondi, Seyed Nasser Ostad, and Narguess Yassa. "Potent cytotoxic flavonoids from Iranian Securigera securidaca." Medicinal Chemistry Research 23, no. 4 (2013): 1718–24. http://dx.doi.org/10.1007/s00044-013-0773-3.

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4

Ghorbani, Ahmad, Reyhaneh Moradi Marjaneh, Ziba Rajaei, and Mousa-Al-Reza Hadjzadeh. "Effects of Securigera securidaca Extract on Lipolysis and Adipogenesis in Diabetic Rats." Cholesterol 2014 (August 3, 2014): 1–5. http://dx.doi.org/10.1155/2014/582106.

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Diabetes mellitus is associated with dysregulation of adipose tissue metabolism and increased level of serum lipids. In our previous work we found that Securigera securidaca decreases cholesterol level in blood of diabetic rats. The present study was carried out to further investigate the effects of this plant on lipid metabolism, lipolysis, and adipogenesis, in diabetic rats. Female Wistar rats were rendered diabetic by intraperitoneal injection of streptozotocin. Retroperitoneal adipose tissue was removed from diabetic animals after seven days of streptozotocin injection. Effect of hydroalco

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5

Tofighi, Zahra, Fahimeh Moradi-Afrapoli, Samad Nejad Ebrahimi, et al. "Securigenin glycosides as hypoglycemic principles of Securigera securidaca seeds." Journal of Natural Medicines 71, no. 1 (2016): 272–80. http://dx.doi.org/10.1007/s11418-016-1060-7.

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6

Schmidt, Bärbel. "Securigera securidaca (L.) Degen et Dörfler-eine Spezies der Gattung Coronilla L." Feddes Repertorium 89, no. 9-10 (2008): 597–600. http://dx.doi.org/10.1002/fedr.19790890905.

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7

Nasehi, Zahra, Mohammad Esmaeil Shahaboddin, and Sadegh Jafarnejad. "The Influence of Securigera securidaca on Diabetes Management in Animal Models: A Systematic Review." Journal of Advances in Medical and Biomedical Research 31, no. 144 (2022): 14–24. https://doi.org/10.30699/jambs.31.144.14.

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<strong>Abstract:</strong>   <strong>Background and Objective: </strong>It has been reported that allopathic drugs do not have significant effects on diabetes treatment. In contemporary literature, much attention has been given to the potential use of traditional medicines, including medicinal plants, in the treatment of metabolic abnormalities. Indeed, the effect of <em>Securigera securidaca</em>, as a medicinal agent, in alleviating the complications of diabetes has received marked attention, particularly in animal models. The aim of this review is to clarify the <em

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8

Shahidi, S., and P. Pahlevani. "Antinociceptive Effects of an Extract of Securigera securidaca and Their Mechanisms in Mice." Neurophysiology 45, no. 1 (2013): 34–38. http://dx.doi.org/10.1007/s11062-013-9334-0.

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9

Hosseinzadeh, H., M. Ramezani, and A. R. Danaei. "Antihyperglycaemic effect and acute toxicity of Securigera Securidaca L. seed extracts in mice." Phytotherapy Research 16, no. 8 (2002): 745–47. http://dx.doi.org/10.1002/ptr.1020.

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10

Azadbakht, Mohammad, Seyyedeh Atiyeh Ahmadi, and Nematollah Ahangar. "Antidiabetic Activity of Aqueous Seed Extract of Securigera securidaca in Streptozotocin Induced Diabetic Rats." Journal of Advances in Medical and Biomedical Research 27, no. 123 (2019): 16–22. http://dx.doi.org/10.30699/jambs.27.123.16.

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11

Ahmadi, Abbas, Mohsen Khalili, Shideh Margedari, and Babak Nahri-Niknafs. "Antidiabetic and Antilipidemic Effects of Some Polar and Nonpolar Extracts of Securigera Securidaca Flowers." Pharmaceutical Chemistry Journal 49, no. 11 (2016): 753–59. http://dx.doi.org/10.1007/s11094-016-1365-6.

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12

HASSAN, AHMED YASSIN. "GOAT PEA (SECURIGERA SECURIDACA L.) SEED YIELD AND PHYTOCHEMICALS IMPROVEMENT THROUGH CROP MANAGEMENT PRACTICES." SABRAO Journal of Breeding and Genetics 55, no. 3 (2023): 992–1002. http://dx.doi.org/10.54910/sabrao2023.55.3.33.

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The presented trial carried out at the District Baqubah, Diyala Governorate, Iraq, assessed the effects of three planting dates (15 October, 05, and 25 November 2018) and four levels of organic fertilizer (0, 150, 250, and 350 kg ha-1) on the seed yield and chemical composition of the goat pea (Securigera securidaca L.). The experiment in a randomized complete block design with a factorial arrangement had three replications. The results showed that the 15 October planting was significantly superior in the percentage and yield of oil and the total content of phenols and glycosides, which amount

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13

Nasehi, Zahra, Mohammad Esmaeil Shahaboddin, and Sadegh Jafarnejad. "The Influence of Securigera securidaca on Diabetes Management in Animal Models: A Systematic Review." Journal of Advances in Medical and Biomedical Research 31, no. 144 (2023): 14–24. http://dx.doi.org/10.30699/jambs.31.144.14.

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14

Khomari, Fatemeh, Bahar Kiani, Shahin Alizadeh-Fanalou, et al. "Effectiveness of Hydroalcoholic Seed Extract of Securigera securidaca on Pancreatic Local Renin-Angiotensin System and Its Alternative Pathway in Streptozotocin-Induced Diabetic Animal Model." Oxidative Medicine and Cellular Longevity 2023 (January 7, 2023): 1–14. http://dx.doi.org/10.1155/2023/7285036.

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Background. Available data suggest inhibition of the pancreatic local-renin-angiotensin system (RAS) reduces tissue complications of diabetes. The purpose of the present study was to investigate the effect of hydroalcoholic seed extract of Securigera securidaca (S. securidaca) (HESS) on the pancreatic local-RAS and its alternative pathway. Methods. Three doses of HESS were orally administered to three groups of diabetic male Wistar rats, and the results were compared with both diabetic and healthy control groups. After 35 days of treatment, the groups were assessed for the levels of pancreatic

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15

Porchezhian, E., and S. H. Ansari. "Effect of Securigera securidaca on Blood Glucose Levels of Normal and Alloxan-Induced Diabetic Rats." Pharmaceutical Biology 39, no. 1 (2001): 62–64. http://dx.doi.org/10.1076/phbi.39.1.62.5949.

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16

Ahmadi, A., M. Khalili, Sh Margedari, and B. Nahri-Niknafs. "The Effects of Solvent Polarity on Hypoglycemic and Hypolipidemic Activities of Securigera Securidaca (L.) Seeds." Drug Research 66, no. 03 (2015): 130–35. http://dx.doi.org/10.1055/s-0035-1555773.

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17

Abdelbagi, Mohamed E. M., Ghassab M. Al-Mazaideh, Adil Elhag Ahmed, et al. "Exploring Securigera securidaca Seeds as a Source of Potential CDK1 Inhibitors: Identification of Hippeastrine and Naringenin as Promising Hit Candidates." Processes 11, no. 5 (2023): 1478. http://dx.doi.org/10.3390/pr11051478.

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CDK1 (cyclin dependent kinase 1) is a key regulator of the cell cycle and is frequently dysregulated in cancer, making it a promising target for anticancer therapy. Securigera securidaca L. (S. securidaca) seeds, traditionally used in folk medicine for various ailments including cancer, were examined for their potential as CDK1/Cks2 inhibitors using in silico approaches. A total of 14 phytocompounds was identified in the GC/MS chromatogram, with gingerone being the most abundant at 25.67% and hippeastrine the least at 2%. Major constituents of the essential extract, including gingerol, eugenol

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18

Mard, S. A., Z. Bahari, N. Eshaghi, and Y. Farbood. "Antiulcerogenic Effect of Securigera securidaca L. Seed Extract on Various Experimental Gastric Ulcer Models in Rats." Pakistan Journal of Biological Sciences 11, no. 23 (2008): 2619–23. http://dx.doi.org/10.3923/pjbs.2008.2619.2623.

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19

Hadjzadeh, Mousa-Al-Reza, Reyhaneh Moradi, Ahmad Ghorbani, Ahmad Saghebi, and Ziba Rajaei. "Antihyperglycemic and antihyperlipidemic effects of hydroalcoholic extract of Securigera securidaca seeds in streptozotocin-induced diabetic rats." Advanced Biomedical Research 4, no. 1 (2015): 33. http://dx.doi.org/10.4103/2277-9175.150427.

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20

Mohasseli, Vahid, Mahmood Izadi, and Mohammad Hadi Roohian. "Effect of salicylic acid on germination and early growth of Securigera securidaca seedling under salinity stress." Journal of Seed Research 9, no. 2 (2023): 163–76. http://dx.doi.org/10.61186/yujs.9.2.163.

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21

EL-Suhaibani, Mariam, Mohammed Asif Ahmed, and Magdi A. Osman. "Study of germination, soaking and cooking effects on the nutritional quality of goat pea (Securigera securidaca L.)." Journal of King Saud University - Science 32, no. 3 (2020): 2029–33. http://dx.doi.org/10.1016/j.jksus.2020.02.021.

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22

BehnamNik, Ali, and Mohsen Vazifedoost. "Optimizing the formulation of the functional beverage from the co-crystalized powder of Securigera securidaca seed extract." Journal of Food Science and Technology 57, no. 7 (2020): 2443–51. http://dx.doi.org/10.1007/s13197-020-04279-8.

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23

Nasehi, Zahra, Nejat Kheiripour, Maryam Akhavan Taheri, et al. "The Protective Effects of Securigera securidaca Seed Extract on Liver Injury Induced by Bile Duct Ligation in Rats." BioMed Research International 2022 (February 4, 2022): 1–12. http://dx.doi.org/10.1155/2022/6989963.

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This study is aimed at evaluating the effects of Securigera securidaca (SS) seed extract on cholestatic liver injury induced by bile duct ligation (BDL) in rats. Total polyphenols and flavonoids in SS seed extract were determined using a colorimetric assay, and their components were quantified using HPLC. Rats in four groups underwent BDL at the common bile duct and were treated for 21 days with either oral distilled water as vehicle, vitamin C, 100 mg/kg SS seed extract, or 200 mg/kg SS seed extract. Rats in the fifth group underwent abdominal incision without BDL and were treated with distil

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24

Nik, Ali Behnam, Mohsen Vazifedoost, Zohreh Didar, and Bahareh Hajirostamloo. "The antioxidant and physicochemical properties of microencapsulated bioactive compounds in Securigera securidaca (L.) seed extract by co-crystallization." Food Quality and Safety 3, no. 4 (2019): 243–50. http://dx.doi.org/10.1093/fqsafe/fyz022.

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Abstract Securigera securidaca seed is a good source of phenolic compounds with high antioxidant properties. Preservation and maintenance of natural antioxidants have always been a challenge and microencapsulation is a suitable method for this purpose. In this study, the chemical compounds of the plant seed extract were identified by GC/MS device. Bioactive compounds from the seed ethanolic extract were microencapsulated in the sucrose matrix during the co-crystallization process. The evaluations included total phenolic compounds, radical scavenging ability, production efficiency, moisture con

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25

Alizadeh-Fanalou, Shahin, Ali Nazarizadeh, Mohammad Babaei, Mohsen Khosravi, Navid Farahmandian, and Elham Bahreini. "Effects of Securigera securidaca (L.) Degen & Dorfl seed extract combined with glibenclamide on paraoxonase1 activity, lipid profile and peroxidation, and cardiovascular risk indices in diabetic rats." BioImpacts 10, no. 3 (2019): 159–67. http://dx.doi.org/10.34172/bi.2020.20.

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Introduction: Seeds of Securigera securidaca (L.) Degen & Dorfl are rich in flavonoids and phenolic acids which have potent biological effects. The current study was undertaken to evaluate the effects of hydroalcoholic extract of S. securidaca seeds (HESS) alone, and in combination with a standard drug, glibenclamide (GB) on paraoxonase1 (PON1) activity, lipid profile and peroxidation, and cardiovascular risk indices in streptozotocin (STZ) induced diabetic rats. Methods: Forty-eight male Wistar rats were randomly divided into eight equal groups and orally treated with various doses of HES

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Ahmadipour, Behnam. "Securigera securidaca seed medicinal herb supplementation of diets improves pulmonary hypertensive response in broiler chickens reared at high altitude." Journal of Animal Physiology and Animal Nutrition 102, no. 6 (2018): 1601–7. http://dx.doi.org/10.1111/jpn.12981.

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27

Ibrahim, Rana M., Ali M. El-Halawany, Dalia O. Saleh, El Moataz Bellah El Naggar, Abd El-Rahman O. El-Shabrawy, and Seham S. El-Hawary. "HPLC-DAD-MS/MS profiling of phenolics from Securigera securidaca flowers and its anti-hyperglycemic and anti-hyperlipidemic activities." Revista Brasileira de Farmacognosia 25, no. 2 (2015): 134–41. http://dx.doi.org/10.1016/j.bjp.2015.02.008.

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28

Hassan, Ahmed Yassin. "The Effect of Spraying with the Hormone Brassinolide on the Production of Oil and Glycosides of Goat Pea (Securigera securidaca)." IOP Conference Series: Earth and Environmental Science 1214, no. 1 (2023): 012046. http://dx.doi.org/10.1088/1755-1315/1214/1/012046.

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Abstract A field experiment was carried out in Diyala Governorate during the winter season 2020-2021 to evaluate the effect of spraying three concentrations of Brassinolide hormone (1, 2 and 3 ppm) in addition to the control treatment (0 ppm) and three dates of spraying (after 20,40 and 60 days of germination) in the production of oil and total glycosides in Securigera securidaca seeds, by using a factorial experiment according to the randomized complete block design. The results showed that the spraying treatment with a concentration of 2 ppm was superior in seed yield, content and yield of o

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29

Naderi, Ruhollah, Mohsen Edalat, and Todd P. Egan. "Organic amendments and urea nitrogen effects the growth and nutrient content of fenugreek (Trigonella foenumgraecum) and goat pea (Securigera securidaca)." Journal of Plant Nutrition 42, no. 19 (2019): 2552–59. http://dx.doi.org/10.1080/01904167.2019.1659354.

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30

Behnamnik, Ali, Mohsen Vazifedoost, Zohreh Didar, and Bahareh Hajirostamloo. "Evaluation of physicochemical, structural, and antioxidant properties of microencapsulated seed extract from Securigera securidaca by co-crystallization method during storage time." Biocatalysis and Agricultural Biotechnology 35 (August 2021): 102090. http://dx.doi.org/10.1016/j.bcab.2021.102090.

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31

Taherian, A., H. Sameni, S. Sadeghi, and M. Taherian. "(318) The role of opioid receptors on anti-nociceptive effects of hydroalcoholic extract of securigera securidaca L. seed in albino mice." Journal of Pain 17, no. 4 (2016): S55. http://dx.doi.org/10.1016/j.jpain.2016.01.225.

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32

HASSAN, AHMED YASSIN. "EFFECT OF PLANTS SPACE AND FOLIAR APPLICATION OF HUMIC ACID IN SEED YIELD AND BIOCHEMICAL COMPOSITION OF GOAT PEA (SECURIGERA SECURIDACA L.)." SABRAO Journal of Breeding and Genetics 55, no. 4 (2023): 1401–10. http://dx.doi.org/10.54910/sabrao2023.55.4.33.

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A field experiment ensued during the winter crop season 2018–2019 at the District Baqubah, Diyala Governorate, Iraq, to study the effects of three plant spacing (20, 40, and 60 cm) and foliar application of humic acid with four concentrations (0, 10, 20, and 40 L ha-1 ) on seed yield-related traits and active ingredients of goat pea (Securigera securidaca L.). The recorded data underwent statistical analysis using a randomized complete block design (RCBD) with factorial arrangement. The results showed that the plant spacing of 60 cm was superior in the percentage of oil and the total content o

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33

Garjani, Alireza, Fatemeh Fathiazad, Arezoo Zakheri, et al. "The effect of total extract of Securigera securidaca L. seeds on serum lipid profiles, antioxidant status, and vascular function in hypercholesterolemic rats." Journal of Ethnopharmacology 126, no. 3 (2009): 525–32. http://dx.doi.org/10.1016/j.jep.2009.09.003.

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34

Ahmadi, Abbas, Mohsen Khalili, Maryam Salimi, Niloofar Mirsistani, Ayda Niksirat, and Sommayeh Nazirzadeh. "The Effects of Solvent Polarity on Analgesic and Anti-Inflammatory Activities of Securigera Securidaca (L.), Achillea Eriophora DC, and Portulaca Oleracea Extracts." Pharmaceutical Chemistry Journal 53, no. 3 (2019): 248–63. http://dx.doi.org/10.1007/s11094-019-01988-z.

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35

Gavanji, Shahin. "The Antiviral Potential of Iranian Herbal Pharmacopoeia (IHP) on Herpes Simplex Viruses (HSV): A Review Article." Biology, Medicine, & Natural Product Chemistry 11, no. 2 (2022): 89–109. http://dx.doi.org/10.14421/biomedich.2022.112.89-109.

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Herpes Simplex Viruses (HSV) viruses are highly contagious that commonly cause dermatitis, encephalitis, meningitis and genitourinary infections and also can lead to cervical cancer. For treatment of HSV infections, several physical methods and antiviral drugs are introduced, antiviral medications can also prevent or reduce outbreaks. The use of herbal medicine with antiviral effects attracted worldwide attentions. The aim of this review article is to introduce the Iranian Herbal Pharmacopoeia (IHP) with antiviral potential against two HSV serotypes and help to evaluate and develop the new dru

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36

Bahreini, Elham, Mohammad Babaei, Forogh Mohammadi, and Shahin Alizadeh-Fanalou. "Evaluation of serum pro/anti-angiogenic biomarkers in hyperglycemic rats treated with Securigera securidaca seeds, alone and in combination with Glibenclamide." Journal of Cardiovascular and Thoracic Research 16, no. 1 (2024): 8–14. http://dx.doi.org/10.34172/jcvtr.32960.

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Introduction: Herbal medicines are commonly used by many people with diabetes in addition to standard treatment. Plants contain numerous known and unknown compounds that may exacerbate or ameliorate diabetes complications. Therefore, it is crucial to be aware of the side effects of these herbs before prescribing them. This study aimed to investigate the effects of hydroalcoholic extracts of Securigera securidaca (HESS) seeds alone and in combination with glibenclamide on the angiogenic/anti-angiogenic balance in streptozotocin (STZ)-induced diabetic rats. Methods: Groups involved in this anima

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37

Alizadeh-Fanalou, Shahin, Mohammad Babaei, Asieh Hosseini, et al. "Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats." Journal of Ethnopharmacology 248 (February 2020): 112331. http://dx.doi.org/10.1016/j.jep.2019.112331.

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38

ALI, A. A., M. H. MOHAMED, M. S. KAMEL, M. A. FOUAD, and O. SPRING. "ChemInform Abstract: Studies on Securigera securidacea (L.) Deg. et Doerfl. (Fabaceae) Seeds, an Antidiabetic Egyptian Folk Medicine." ChemInform 30, no. 4 (2010): no. http://dx.doi.org/10.1002/chin.199904190.

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39

"Securigera securidaca." CABI Compendium CABI Compendium (January 7, 2022). http://dx.doi.org/10.1079/cabicompendium.117016.

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40

Raesi Vanani, Atefeh, Masoud Mahdavinia, Heibatullah Kalantari, Saeed Khoshnood, and Maryam Shirani. "Antifungal effect of the effect of Securigera securidaca L. vaginal gel on Candida species." Current Medical Mycology, November 2, 2019. http://dx.doi.org/10.18502/cmm.5.3.1744.

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Background and Purpose: Candida species are opportunistic fungi, capable of causing acute and chronic infections in the gastrointestinal tract, vagina, and oral mucosa, among which Candida albicans is the most important species. The Securigera securidaca L. is used as an antiseptic to treat some diseases in traditional Iranian medicine. The aim of this study was to evaluate the antimicrobial activity of S. securidaca extracts and vaginal gel against different Candida species. Materials and Methods: Antifungal effects of different extracts and vaginal gel of S. securidaca were investigate

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41

Mazaideh, Ghassab M. Al, and Saleh A. Al Quran. "Effect of Methanolic Extract of Securigera securidaca as Antioxidant and Antibacterial Activities." Journal of Pharmaceutical Research International, July 6, 2020, 10–17. http://dx.doi.org/10.9734/jpri/2020/v32i1130498.

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In the present work, the phytochemical screening, polyphenolic content, antibacterial activity and antioxidant activity of Securigera securidaca seeds in methanol were carried out. Phytochemical analysis of seeds showed the presence of alkaloids, flavonoids, saponins, terpenoids, steroids and glycosides. Total phenolic content was estimated by Folin Ciocalteau method and the result showed the highest phenolic content of 62.28 mg/g. Methanolic extract was screened for antibacterial activity by disc diffusion method and it found to be potent. The MIC of methanol extract identified by broth dilut

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42

"Phytochemical Constituents of Securigera securidaca Seed Extract Using GS-MS and HPLC." Tropical Journal of Natural Product Research 4, no. 9 (2020): 540–44. http://dx.doi.org/10.26538/tjnpr/v4i9.8.

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43

Babaei, Mohammad, Shahin Alizadeh-Fanalou, Alireza Nourian, et al. "Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide." Reproductive Biology and Endocrinology 19, no. 1 (2021). http://dx.doi.org/10.1186/s12958-021-00794-1.

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AbstractStructural and physiological changes in sperm and semen parameters reduce fertility in diabetic patients. Securigera Securidaca (S. Securidaca) seed is a herbal medicine with hypoglycemic, antioxidant, and anti-hypertensive effects. The question now is whether this herbal medicine improves fertility in diabetic males. The study aimed to evaluate the effects of hydroalcoholic extract of S. Securidaca seeds (HESS), glibenclamide and a combination of both on fertility in hyperglycemic rats by comparing histological and some biochemical changes in testicular tissue and sperm parameters. Th

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44

Soltani, Mohammad. "Evaluation of Anti-Herpetic Activity of Methanol Seed Extract and Fractions of Securigera securidaca In vitro." Journal of Antivirals & Antiretrovirals 05, no. 04 (2013). http://dx.doi.org/10.4172/jaa.1000066.

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45

Aldal’in, H., A. H. Al-Nadaf, A. Awadallah, S. Thiab, and H. M. Bastoni. "Methanolic extract of S. securidaca flowers, leaves, and seeds' antihyperlipidemic effects on high fat diet-induced hyperlipidemia in Wistar rats." Brazilian Journal of Biology 83 (2023). http://dx.doi.org/10.1590/1519-6984.275382.

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Abstract Significant risk factors for atherosclerosis include hyperlipidemia and oxidative stress, which together rank as three of the most significant risk factors for cardiovascular diseases. Securigera securidaca lowers cholesterol levels in diabetic rats' blood. This investigation's objective was to determine how methanolic extracts affected the flowers, leaves, and seeds of plants in rats that were fed a high-fat diet (HFD). Five groups of animals were created (n = 5). A total of 35 days, divided into two intervals, were used for the study. Rats received HFD during the first 15-day interv

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46

Garjani, A., F. Fathiazad, A. Zakheri, N. Allaf-Akbari, Y. Azarmie, and N. Maleki-Dizaji. "The effect of total extract of Securigera securidaca L. seeds on serum lipid profiles and vascular function in hypercholesterolemic rats." Planta Medica 75, no. 09 (2009). http://dx.doi.org/10.1055/s-0029-1234739.

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Hasani, Maryam, Ebrahim Abbasi‐Oshaghi, Fatemeh Khomari, et al. "Enhanced Insulin Secretion Through Upregulation of Transcription Factors by Hydroalcoholic Extract of Securigera securidaca Seeds in Diabetic Animal Model." Endocrinology, Diabetes & Metabolism 7, no. 5 (2024). http://dx.doi.org/10.1002/edm2.515.

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Abstract:

ABSTRACTAimIn previous studies, the researchers observed an increase in insulin secretion in STZ‐treated diabetic rats following treatment with the hydroalcoholic extract of Securigera securidaca (HESS) seeds. This study focuses on the relationship between the antioxidant properties of HESS with changes in diabetic pancreatic tissue and the gene expression of factors that impact insulin secretion.MethodsIn this controlled experimental study, three varying doses of HESS were administered to three groups of diabetic rats induced by STZ. Oxidative stress indicators like total antioxidant capacity

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Kiani, Bahar, Shahin Alizadeh-Fanalou, Fatemeh Khomari, et al. "The Effect of Hydroalcoholic Seed Extract of Securigera Securidaca on the Hepatic Renin-Angiotensin System in the Streptozotocin-Induced Diabetic Animal Model." Clinical Diabetology, March 3, 2022. http://dx.doi.org/10.5603/dk.a2022.0013.

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Mollania, Fariba, та Hossein Sahabi. "Investigating the ability of Securigera securidaca extract in biological synthesis of selenium nanoparticles, pancreatic α-amylase inhibition, antioxidant and phenolic capacity and in vivo studying the anti-diabetic effects of extract on pseudo-diabetic rats". Nanotechnology for Environmental Engineering, 21 листопада 2021. http://dx.doi.org/10.1007/s41204-021-00177-2.

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