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1

G, Whitwam J., ed. Principles and practice of sedation. Blackwell Science, 1998.

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2

MSN, Watson Donna, and Watson Donna MSN, eds. Practical guide to moderate sedation/analgesia. 2nd ed. Elsevier Mosby, 2005.

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3

Center, Oregon Prevention Resource, and National Institute on Drug Abuse., eds. Sedative-hypnotics. Oregon Prevention Resource Center, Office of Alcohol and Drug Abuse Programs, Dept. of Human Resources, 1997.

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4

Center, Oregon Prevention Resource, and National Institute on Drug Abuse., eds. Sedative-hypnotics. Oregon Prevention Resource Center, Office of Alcohol and Drug Abuse Programs, Dept. of Human Resources, 1997.

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5

Vähä-Vahe, Tapani. Pharmacological restraint: Reversal in dogs and cats using medetomidine andatipamezole. Serioffset, 1991.

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6

Kopelson, Kevin. Sedaris. University of Minnesota Press, 2007.

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7

Horoṿits, Shirʾel. Sedaḳim. Saʻar, 1996.

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8

Horoṿits, Shirʼel. Sedaḳim. Saʻar, 1996.

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9

Skelly, Meg. Conscious Sedation. John Wiley & Sons, Ltd., 2006.

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10

Nihād-i Taḥqīqātī-i Ḥuqūq-i Zanān va Aṭfāl., ed. Bad painful sedative: Final report. Women and Children Legal Research Foundation (WCLRF), 2004.

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11

Davies, James, ed. The Sedated Society. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-44911-1.

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12

De Gaudio, Angelo Raffaele, and Stefano Romagnoli, eds. Critical Care Sedation. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-59312-8.

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13

Watson, Donna. Conscious sedation/analgesia. Mosby, 1998.

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14

Park, G. R. Sedation and analgesia. Saunders, 1993.

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15

Scott, Celicia. Dangerous Depressants & Sedatives. Mason Crest, 2015.

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16

Ross, Lindsay G., and Barbara Ross, eds. Anaesthetic and Sedative Techniques for Aquatic Animals. Blackwell Publishing Ltd., 2008. http://dx.doi.org/10.1002/9781444302264.

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17

D, Ross Barbara Ph, ed. Anaesthetic and sedative techniques for aquatic animals. 2nd ed. Blackwell Science, 1999.

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18

M, Girdler N., Wilson Kathy 1963-, and Hill C. M, eds. Clinical sedation in dentistry. Blackwell, 2009.

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19

Drigues, Judith. Sheʻat ha-sedaḳim: Shirim. Karmel, 2010.

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20

Ammermann), Andrea Kirchhoff (geb. Einfluss der kombinierten Anwendung von Flunitrazepam mit anderen sedativ wirkenden Psychopharmaka auf zentralnervöse Funktionen bei weissen Mäusen. 1985.

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21

Patel, Bhakti K., and John P. Kress. Management of sedation in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0359.

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Once adequate analgesia is confirmed, the need for sedation should be considered. Sedation of mechanically-ventilated patients is a common challenge in the intensive care unit (ICU). Metabolism of sedatives in critical illness can be unpredictable and achieving optimal sedation without coma is a moving target. Once adequate analgesia is achieved, the choice, depth, and duration of sedation can have major implications for the presence of delirium, the duration of mechanical ventilation, ventilator-associated pneumonia, and ICU length of stay. Therefore, goal-directed titration of sedative and f
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22

Sessler, Curtis N., and Katie M. Muzevich. Sedatives and anti-anxiety agents in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0042.

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Sedative and anti-anxiety agents are administered to many mechanically-ventilated intensive care unit (ICU) patients. While commonly considered supportive care, suboptimal administration of sedatives has been linked to longer duration of mechanical ventilation and longer ICU length of stay. The use of a structured multidisciplinary approach can help improve outcomes. The level of consciousness, as well as the presence and severity of agitation should be routinely evaluated using a validated sedation–agitation scale. The approach to delivery of sedation should be based upon specific goals, part
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23

Urman, Richard D., and Alan D. Kaye. Moderate and Deep Sedation in Clinical Practice. Cambridge University Press, 2012.

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24

Kaye, Alan David, and Richard D. Urman. Moderate and Deep Sedation in Clinical Practice. Cambridge University Press, 2017.

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25

Kaye, Alan David, and Richard D. Urman. Moderate and Deep Sedation in Clinical Practice. Cambridge University Press, 2017.

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26

Metzner, Julia, and Karen B. Domino. Procedural Sedation by Nonanesthesia Providers. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190495756.003.0009.

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Although anesthesiologists and certified registered nurse anesthetists are experts in sedation/analgesia outside of the operating room, extensive demand in the face of limited resources has resulted in sedation being routinely performed by nonanesthesia health care providers. Safe administration of procedural sedation/analgesia by nonanesthesia professionals requires an understanding of the continuum of sedation/general anesthesia; extensive training and credentialing of personnel performing sedation; appropriate patient preparation and selection, with an anesthesia consult for higher-risk pat
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27

JOHNSON, Frederick. Sedative Addiction: Everything You Need to Know about Sedative Addiction. Independently Published, 2021.

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28

Galvin, Sinead, Lisa Burry, and Sangeeta Mehta. Rethinking Sedation in the ICU. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199653461.003.0040.

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Analgesic and sedative medications are commonly given to manage pain, anxiety, and delirium in critically ill patients; such agents are also used to facilitate painful procedures and to promote greater tolerance of mechanical ventilation. The manner in which we administer, titrate, and monitor analgesia and sedation in the ICU can have an impact on both short- and long-term patient outcomes. The benefit of sedation strategies that limit drug exposure and promote greater wakefulness and patient interaction has been demonstrated in several randomized trials. The overall objective of sedation in
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29

Frei. Sedartis. Primedia eLaunch LLC, 2018.

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30

Sedation. Elsevier, 2010. http://dx.doi.org/10.1016/b978-0-323-05680-9.x0001-x.

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31

Sedaris. Univ Of Minnesota Press, 2007.

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32

Imhauser, Rebecca Carr. Sedalia. Arcadia Publishing Library Editions, 2019.

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33

Imhauser, Rebecca Carr. Sedalia. Arcadia Publishing, 2016.

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34

Imhauser, Rebecca Carr. Sedalia. Arcadia Publishing, 2007.

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35

Imhauser, Rebecca Carr. Sedalia. Arcadia Publishing, 2019.

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36

Imhauser, Rebecca Carr. Sedalia. Arcadia Publishing, 2016.

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37

Imhauser, Rebecca Carr. Sedalia. Arcadia Publishing, 2007.

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38

Imhauser, Rebecca Carr. Sedalia. Arcadia Publishing, 2016.

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39

FREI. Sedartis. Optimist Books by Optimist Creations, 2018.

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40

Sedaris. Univ Of Minnesota Press, 2007.

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41

Sedalia. Arcadia Pub., 2007.

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42

Sedalia. Pulphouse Publishing, 1998.

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43

Mistraletti, Giovanni, and Gaetano Iapichino. Sedation assessment in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0358.

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Patient comfort is a primary goal in ICU, but achieving and maintaining the appropriate balance of analgesia, sedation, and treatment of delirium is frequently challenging. International guidelines recommend keeping critically-ill patients calm and cooperative, awake in daytime and asleep at night, always avoiding deep sedation. To state the actual level of sedation and the desired one, it is necessary to frequently perform a sedation assessment with validated tools. Subjective methods are the most useful guides in ICU consciously-sedated patients, representing the gold standard for good clini
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44

Leung, Kami. Sedate. Blurb, 2017.

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45

Knape, Johannes (Hans) T. A. Conscious sedation. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0050.

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After a thorough introduction to conscious sedation, including the reasons for the increase in demand for assistance for moderate (conscious)-to-deep sedation in medicine over recent decades, this chapter covers some key definitions, before moving on to morbidity, mortality, and safety. The chapter then discusses how to prepare the patient for sedation, including the issue of whether the patient should have fasted prior to sedation and the screening of patients for sedation. It looks at the necessary qualifications and responsibilities of a sedation practitioner, and the monitoring of patients
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46

Schow, David J. Sedalia Signed. Pulphouse Publishing, 1991.

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47

Nelson, Peg. Palliative Sedation. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190204709.003.0013.

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This chapter examines palliative sedation and the advanced practice registered nurse’s (APRN) roles and responsibilities when caring for patients with intractable suffering at the end of life. Palliative sedation is an important therapy of last resort to relieve suffering in patients who have intractable pain and/or other symptoms. It requires knowledge of appropriate medications and an interdisciplinary approach. The chapter discusses definitions of palliative sedation and situations where it is appropriate. Key aspects of safe implementation and appropriate medications for palliative sedatio
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48

Conscious sedation. W.B. Saunders, 1997.

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49

Conscious sedation. Saunders, 1997.

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50

David Sedaris. Little Brown & Company, 2002.

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