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Relevant bibliographies by topics / Sedative properties

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Academic literature on the topic 'Sedative properties'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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Journal articles on the topic "Sedative properties"

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Deviatkina, Nataliia, Jha Sahil kumar, and Rauth Upasona. "The use of sedative medications, their prevalence, and their sedation of patients with disorders of consciousness, as well as the stimulating and sedative effects of alcohol." InterConf, no. 27(133) (November 20, 2022): 243–50. http://dx.doi.org/10.51582/interconf.19-20.11.2022.023.

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Medicinal sedatives are a class of drugs that reduce brain activity. You can usually utilise them to relax yourself. Sedatives are usually prescribed by doctors to address conditions like anxiety and sleep problems. Additionally, they are used as general anaesthetics. Regulated chemicals include sedatives.Sedatives, which include benzodiazepines, selective benzodiazepine receptor subtype agonists (z-drugs), and barbiturates, are commonly prescribed for anxiety or insomnia. These sedatives are considered banned substances because of the possibility of abuse and misuse. Self-medication (pharmace

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Gupta, Surabhi. "A comparative study of dexmedetomidine propofol and midazolam with respect to changes in mean arterial pressure and SpO2 after sedation at tertiary health care centre." MedPulse International Journal of Anesthesiology 16, no. 3 (2021): 148–52. http://dx.doi.org/10.26611/101516319.

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Background: Sedation is an important component of compassionate care in ICU patients to promote rest and sleep. The sedatives used most often include propofol and midazolam. These medications provide adequate sedation but also can cause oversedation. The α2 agonist dexmedetomidine have unique sedative properties that it produces only mild cognitive impairment, allowing easy communication between health-care provider and patient in the ICU. We therefore compared the sedative and analgesic properties, cardiovascular responses, ventilation and extubation characteristics, and patient perceptions o

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Bhatt‐Mehta, Varsha, and David A. Rosen. "Sedation in Children: Current Concepts." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 18, no. 4 (1998): 790–807. http://dx.doi.org/10.1002/j.1875-9114.1998.tb03900.x.

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Sedation in children poses a great challenge, with the main concern one of safety. The importance of providing adequate sedation to children was realized only in the last decade and a half, and relevant data are severely lacking. Use of potent sedative agents is not without risk. Children are given sedative agents in a wide variety of settings by practitioners with different degrees of experience with the drugs and management of adverse effects. Controversial issues must be addressed in this area, and appropriate tools developed to measure sedation and individualize treatment based on the drug

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Kawauchi, Hideyuki, Kazuhiko Yanai, De-Yun Wang, Koju Itahashi, and Kimihiro Okubo. "Antihistamines for Allergic Rhinitis Treatment from the Viewpoint of Nonsedative Properties." International Journal of Molecular Sciences 20, no. 1 (2019): 213. http://dx.doi.org/10.3390/ijms20010213.

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Antihistamines targeting the histamine H1 receptor play an important role in improving and maintaining the quality of life of patients with allergic rhinitis. For more effective and safer use of second-generation drugs, which are recommended by various guidelines, a classification based on their detailed characteristics is necessary. Antihistamines for first-line therapy should not have central depressant/sedative activities. Sedative properties (drowsiness and impaired performance) are associated with the inhibition of central histamine neurons. Brain H1 receptor occupancy (H1RO) is a useful

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Akhtar, Ahmed Bilal, Muhammad Khurram Ijaz, Adeel Bashir, and Ahsun Waqar Khan. "Intranasal Dexmedetomidine as Sedative for Non-Invasive Pediatric Diagnostic Procedures Outside Operating Room." Annals of King Edward Medical University 28, no. 2 (2022): 188–92. http://dx.doi.org/10.21649/akemu.v28i2.5083.

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Background: Children often require sedation for long non-invasive diagnostic procedures. Dexmedetomidine is a highly selective alpha 2-adrenoceptor agonist with sedative, anxiolytic and analgesic properties. It mimics natural sleep and allows patients to easily arouse with minimal effects on respiration and airway patency. Objective: To assess the successful completion of pediatric non-invasive diagnostic procedures with intranasal dexmedetomidine as a sedative agent. Methods: Seventy-nine subjects of age six months to twelve years scheduled for non-invasive diagnostic procedures were included

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Halitoğullari, Nazlı, Ferit Yildiz, and Musa GenÇcelep. "Effects of Xylazin on sedative, analgesic and some liver enzymes in rats." Revista Científica de la Facultad de Ciencias Veterinarias 35, no. 2 (2025): 9. https://doi.org/10.52973/rcfcv-e35612.

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This study was conducted to determine the sedation level of rats after using two different doses of Xylazine, to measure the damage that may occur in the liver, and to determine the change in pain response due to sedation. The use of analgesic substances is one of preferred methods in pain control studies. Analgesic effects are also present in drugs used for sedative purposes. Xylazine is used for pain relief, calming (sedative), sleep inducing (hypnotic), and striated muscle relaxation. It is also used for premedication purposes before using different anesthetic drugs. 24 rats used in the stu

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Miller, Jamie L., Christine Allen, and Peter N. Johnson. "Neurologic Withdrawal Symptoms Following Abrupt Discontinuation of a Prolonged Dexmedetomidine Infusion in a Child." Journal of Pediatric Pharmacology and Therapeutics 15, no. 1 (2010): 38–42. http://dx.doi.org/10.5863/1551-6776-15.1.38.

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Dexmedetomidine is a α2-adrenergic agonist which possesses sedative, analgesic, and anxiolytic properties. It is approved for short-term use in adults to provide sedation while mechanically ventilated and for noninvasive procedural sedation. An increased number of anecdotal reports describe the use dexmedetomidine in children. Cardiovascular withdrawal symptoms have been reported in the literature. However, there have been few published reports of neurologic withdrawal symptoms following discontinuation of prolonged infusions of dexmedetomidine. We describe a 2 year-old child who received a pr

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Kornyushenkov, Evgeniy. "Alpha-2adrenoreceptor agonists. Dexmethedomidine." Russian veterinary journal 2024, no. 2 (2024): 47–51. http://dx.doi.org/10.32416/2500-4379-2024-2-47-51.

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Dexmethedomidine is a selective alpha2-adrenoreceptor agonist with a powerful sedative effect and analgesic properties. High selectivity of dexmedetomide (1620:1) makes it the optimal drug among all representatives of the alpha-2adrenoreceptor agonist class for use in relatively small animals. Dexmedetomidine is currently the most popular sedative used for premedication and sedation, as well as in multimodal analgesia in a constant-rate infusion mode in intensive care. In 2024, a domestic drug with the trade name «Dexody» of the pharmaceutical company «Apicenna» with the active substance dexme

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Sago, Teppei, Shunji Shiiba, Eika Ando, et al. "Sedation With a Combination of Dexmedetomidine and Midazolam for Pediatric Dental Surgery." Anesthesia Progress 65, no. 2 (2018): 124–26. http://dx.doi.org/10.2344/anpr-65-03-14.

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Intravenous sedation (IVS) is commonly used to complete dental treatment for uncooperative pediatric patients. Propofol (PRO) is widely used for IVS because of its short context sensitive half-time and amnestic effect. However, administering PRO to patients who have a history of egg anaphylaxis is still somewhat controversial. The evidence that supports the potential risks for allergic reactions following PRO use in patients with egg allergies is limited with some anesthesiologists recommending against its use in these patients. Alternative drug regimens for procedural sedation in this populat

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Lim, Renly, Lisa M. Kalisch Ellett, Imaina S. Widagdo, Nicole L. Pratt, and Elizabeth Ellen Roughead. "Analysis of anticholinergic and sedative medicine effects on physical function, cognitive function, appetite and frailty: a cross-sectional study in Australia." BMJ Open 9, no. 9 (2019): e029221. http://dx.doi.org/10.1136/bmjopen-2019-029221.

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ObjectiveTo test the association between use of medicines with anticholinergic or sedative properties and physical function, cognitive function, appetite and frailty.Design, setting and participantsThis cross-sectional study analysed baseline data collected as part of the Australian Longitudinal Study of Ageing, a population-based cohort of 2087 participants aged 65 years or over living in South Australia.Main outcome measuresPhysical function was measured at baseline using measures including hand grip strength, walking speed, chair stands, activities of daily living and instrumental activitie

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Dissertations / Theses on the topic "Sedative properties"

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Atkinson, Susan. "Studies concerning the sedative and anaesthetic properties of midazolam and propofol." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261764.

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Клочко, А. Д. "Вплив ОВП харчових продуктів на їхні седативні властивості". Thesis, Сумський державний університет, 2018. http://essuir.sumdu.edu.ua/handle/123456789/66782.

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Books on the topic "Sedative properties"

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Metzner, Julia, and Karen B. Domino. Procedural Sedation by Nonanesthesia Providers. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190495756.003.0009.

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Although anesthesiologists and certified registered nurse anesthetists are experts in sedation/analgesia outside of the operating room, extensive demand in the face of limited resources has resulted in sedation being routinely performed by nonanesthesia health care providers. Safe administration of procedural sedation/analgesia by nonanesthesia professionals requires an understanding of the continuum of sedation/general anesthesia; extensive training and credentialing of personnel performing sedation; appropriate patient preparation and selection, with an anesthesia consult for higher-risk pat

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Excellent Properties of Salted Brandy, As a Most Efficacious Medicine and Sedative for Internal As Well As External Diseases. Creative Media Partners, LLC, 2022.

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Excellent Properties of Salted Brandy, As a Most Efficacious Medicine and Sedative for Internal As Well As External Diseases. Creative Media Partners, LLC, 2022.

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Absalom, Anthony, and John Sear. Intravenous anaesthetics. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0015.

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In recent decades, increasing attention has been focused on the intravenous anaesthetic agents. This interest has been stimulated by the discovery and availability of agents with increasingly favourable pharmacokinetic and dynamic properties, coupled with advances in knowledge of pharmacology and advances in computer technology. For most patients and operative procedures, anaesthesia is induced with a bolus or fast infusion of a short-acting drug, most commonly propofol. Increasingly, anaesthesia is thereafter also maintained with an infusion of an agent with favourable kinetics, again usually

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Beydon, Laurent, and Flavie Duc. Inhalational anaesthetic agents in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0046.

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Inhalational anaesthetic agents have limited applications in the intensive care unit (ICU), as their delivery requires specific equipment, which are not routinely available. Sevoflurane and isoflurane are the two agents eligible for this purpose. They both show good clinical tolerance and versatility, but may raise cerebral blood flow above 1 minimum alveolar concentration. This property makes them unsuitable for sedation in patients suffering from acute brain injury. Sevoflurane is known to be partly metabolized via the cytochrome pathway in inorganic fluoride. This latter accumulates in a do

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Carlucci, Annalisa, and Paolo Navalesi. Weaning failure in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0103.

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Weaning failure has been defined as failure to discontinue mechanical ventilation, as assessed by the spontaneous breathing trial, or need for re-intubation after extubation, so-called extubation failure. Both events represent major clinical and economic burdens, and are associated with high morbidity and mortality. The most important mechanism leading to discontinuation failure is an unfavourable balance between respiratory muscle capacity and the load they must face. Beyond specific diseases leading to loss of muscle force-generating capacity, other factors may impair respiratory muscle func

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Book chapters on the topic "Sedative properties"

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Sanger, D. J. "Discriminative Stimulus Properties of Anxiolytic and Sedative Drugs: Pharmacological Specificity." In Transduction Mechanisms of Drug Stimuli. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73223-2_6.

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Stephens, D. N., L. Turski, G. H. Jones, K. G. Steppuhn та H. H. Schneider. "Abecarnil: A Novel Anxiolytic with Mixed Full Agonist/Partial Agonist Properties in Animal Models of Anxiety and Sedation". У Anxiolytic β-Carbolines. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-78451-4_7.

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Ferguson, Kris, and R. Scott Stayner. "Dexmedetomidine." In Basic Anesthesia Review, edited by Alaa Abd-Elsayed. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780197584569.003.0078.

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Abstract Dexmedetomidine is unique as it produces “cooperative sedation.” It has axiolytic, sedative and analgesic properties. Dexmedetomidine acts as an alpha2-adrenergic receptor agonist in a similar way to clonidine. It decreases the dose requirement of inhaled and intravenous anesthetics as well as opioids and benzodiazepines. Dexmedetomidine maintains the airway and spontaneous ventilation, thereby enhancing the safety of awake fiberoptic intubation. There is blunting of the sympathetic response to noxious stimuli, making for stable hemodynamics throughout a surgical case. Emergence delir

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Horvath, Balazs, and Benjamin Kloesel. "Alpha-2 Agonists." In Basic Anesthesia Review, edited by Alaa Abd-Elsayed. Oxford University PressNew York, 2024. http://dx.doi.org/10.1093/med/9780197584569.003.0154.

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Abstract The alpha-2 adrenoreceptor agonists clonidine and dexmedetomidine possess sedative and analgesic properties without significant cardiovascular or respiratory depression as side effects. That, along with the versatile routes of administration, has made them integral elements of sedation for various procedures and in the intensive care unit. They are effective adjuvants to general and regional anesthesia, as well as to multimodal acute and chronic pain control. This chapter reviews the key pharmacological and clinical information that guides the safe and effective utilization of clonidi

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Li, Chang-Lei, Xiao-Qing Chen, Hui-Ling Yi, and Bao-Miao Ma. "Effect of Repeated Application of Flos Daturae on Sedative and Hypnotic in Mice." In Studies in Health Technology and Informatics. IOS Press, 2023. http://dx.doi.org/10.3233/shti230822.

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Insomnia is one of the most common sleep-related diseases. In traditional Chinese medicine, Flos daturae has been used as a traditional herbal totreatment of sizens of diseases. The research objective was to investigate the sedative and hypnotic effects of Flos Daturae. Kunming mice were divided into control group, Estazolam (positive drug, 0.0005 g/kg) group and Flos Daturae groups (0.01, 0.02, 0.04g/kg) with random, ig once a day for 7 days. The central sedative effect of flos Daturae on the spontaneous activity of mice was observed using the locomotive activity test, and the hypnotic effect

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Blackburn, Thomas P. "Actions of Drugs on The Brain and CNS Disorders." In Pharmacology for Chemists: Drug Discovery in Context. The Royal Society of Chemistry, 2017. http://dx.doi.org/10.1039/bk9781782621423-00130.

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The psychiatric and neurological drugs reviewed in this section include anxiolytics, antidepressants, antipsychotics, sedative-hypnotics, anticonvulsants, and general and local anaesthetics. The pharmacology and chemistry for various classes of CNS drugs show several commonalities. For example, sedative-hypnotics also possess anxiolytic and anticonvulsant properties and at higher concentrations are general anaesthetics. Antipsychotics, also possess sedative-like/anxiolytic properties, but are unique in that they ameliorate the positive or negative thought disorders of schizophrenia. The struct

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Shah, Nimit K., and Piotr Al-Jindi. "α2-Agonists." In Advanced Anesthesia Review, edited by Alaa Abd-Elsayed. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/med/9780197584521.003.0046.

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Abstract The α2-receptors bind with norepinephrine (NE) and epinephrine (E) and inhibit the release of further NE and subsequent neural firing. The two potent α2-agonists used in practice are dexmedetomidine and clonidine. Dexmedetomidine is a specific α2-adrenoceptor agonist with sedative, anxiolytic, analgesic, and sympatholytic properties. It has minimal effect on respiratory drive, which is a key advantage. It has a quick onset and short duration of action. Currently, it has only been licensed for use in intravenous infusions in the intensive care unit (ICU) for 24 hours. If used more than

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Jowza, Maryam, and Dominika James. "Epilepsy." In Advanced Anesthesia Review, edited by Alaa Abd-Elsayed. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/med/9780197584521.003.0058.

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Abstract Seizures are among the most common neurological disorders encountered by anesthesiologists. Prevention and treatment of perioperative seizure is of utmost importance during neurosurgical procedures as uncontrolled seizures increase brain tissue metabolic demand and lead to poor operative outcomes. Perioperative use of antiepileptic drugs (AEDs) effectively decreases risk of intraoperative seizure events. AEDs, although very effective, are associated with many adverse effects and can interact with anesthetic agents. Phenytoin, phenobarbital, and carbamazepine induce hepatic microsomal

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Sanz, Juan G. Ripoll, and Jose L. Diaz-Gomez. "Sedation and Analgesia." In Mayo Clinic Critical and Neurocritical Care Board Review, edited by Eelco F. M. Wijdicks, James Y. Findlay, William D. Freeman, and Ayan Sen. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190862923.003.0135.

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Although sedatives and analgesics differ in pharmacologic properties, both produce sedation. Opioids are the most commonly used and most effective analgesics. However the two should be clearly separated. Sedatives should be considered the primary choice for sedation in the intensive care units and opioids are preferred for pain management after major surgery periprocedural use to avoid pain in a conscious patients, patients with poly trauma particarly major fractures, or patients who are known to chronically use these agents and may withdraw quickly with major consequences for management.

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Barnett, Shannon R., and Mark A. Riddle. "Anxiolytics: benzodiazepines, buspirone, and others." In Pediatric Psychopharmacology: Principles and Practice. Oxford University PressNew York, NY, 2002. http://dx.doi.org/10.1093/oso/9780195141733.003.0027.

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Abstract In the treatment of children and adolescents with anxiety disorders clinicians have a wide variety of pharmacologic options beyond the antidepressants (Shader and Greenblatt, 1995; Lydiard et al., 1996; Riddle et al., 1999). The benzodiazepines (BZs), with their favorable safety profile and quick onset of action, are attractive alternatives for the treatment of acute anxiety. While the clinical effectiveness of buspirone has not been proven in children, buspirone is used alone or in combination with other drugs in the treatment of anxiety disorders. The antihistamines are often used t

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Conference papers on the topic "Sedative properties"

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YANAI, KAZUHIKO, TAKEO YOSHIKAWA, SHOZO FURUMOTO, NOBUYUKI OKAMURA, YOSHIHITO FUNAKI, and REN IWATA. "MOLECULAR IMAGING OF SEDATIVE PROPERTIES CAUSED BY ANTIHISTAMINES." In Proceedings of the Tohoku University Global Centre of Excellence Programme. IMPERIAL COLLEGE PRESS, 2012. http://dx.doi.org/10.1142/9781848169067_0028.

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D.V., Rudoy, Olshevskaya A.V., Pavlov P.D., Odabashyan M.Yu., Ugrekhelidze N.T., and Egyan M.A. "LAVENDER AND ITS INTERACTION WITH THE NERVOUS SYSTEM." In INTERNATIONAL FORUM "YOUTH IN THE AGRIBUSINESS". DSTU-Print, 2022. http://dx.doi.org/10.23947/young.2022.41-44.

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Traditionally, lavender is believed to have various therapeutic and curative properties, ranging from inducing relaxation and ending with the treatment of parasitic infections, burns, insect bites and spasms. There is more and more evidence that lavender oil can be an effective drug in the treatment of certain neurological disorders. Some animal and human studies point to the anxiolytic, mood-stabilizing, sedative, analgesic, anticonvulsant and neuroprotective properties of lavender. These studies have raised the possibility of reviving the therapeutic efficacy of lavender in neurological diso

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Elrefahy, Ahmad H. "Effects of Dexmedetomidine as an Adjunct to General Anesthesia on Postoperative Pain and Opioid Consumption in Major Abdominal Surgery." In 28th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2024. http://dx.doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.1_2024.

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This review examines the impact of dexmedetomidine, an alpha-2 adrenergic receptor agonist, on postoperative pain and opioid consumption in major abdominal surgery. Dexmedetomidine, known for its sedative, analgesic, and opioid-sparing properties, is increasingly used as an adjunct to anesthesia. Analyzing existing literature, the review found that dexmedetomidine administration alongside general anesthesia significantly improves postoperative pain management and reduces opioid consumption. Patients receiving dexmedetomidine reported decreased postoperative pain ratings and required fewer opio

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Petrovic, Anica M., Jovana V. Bradic, and Vladimir Lj Jakovljevic. "The influence of the methanol extract of Galium verum on cardiac oxidative damage in hypertensive rats in a model of global ischemia." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.571p.

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Galium verum (G. verum, Lady ҆s bedstraw) is a perennial herbaceous plant that has been used for centuries as a sedative, an anticancer agent, in the treatment of gout, epilepsy, as antioxidant. Previous studies confirmed cardioprotective properties of this plant species extract in animal models of heart dysfunction, however, the impact of G. verum consumption on cardiac redox state in a condition of global ischemia has not been fully clarified. Therefore, our goal was to examine the effect of G. verum methanol extract on cardiac redox state in spontaneously hypertensive rats in the model of g

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de Lacerda, Dhiego Alves, Pedro Fechine Honorato, José George Ferreira de Albuquerque, et al. "Pharmacology of general anesthetic agents in cardiac surgery: Pharmacokinetic and pharmacodynamic properties." In III Seven International Medical and Nursing Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/iiicongressmedicalnursing-035.

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INTRODUCTION: General anesthetic agents play a crucial role in cardiac surgery, providing analgesia, amnesia, muscle relaxation and control of autonomic responses. The appropriate choice of these agents is essential to ensure hemodynamic stability and minimize perioperative risks. Understanding the pharmacokinetic and pharmacodynamic properties of general anesthetics is essential to optimize anesthetic management in patients undergoing cardiac procedures. OBJECTIVE: This study aims to review and synthesize the recent literature on the pharmacokinetic and pharmacodynamic properties of the main

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Spinella, Toni, Sherry Stewart, Julia Naugler, Igor Yakovenko, and Sean Barrett. "The power of placebo: Does cannabidiol (CBD) expectancy alone impact acute stress and anxiety?" In 2022 Annual Scientific Meeting of the Research Society on Marijuana. Research Society on Marijuana, 2022. http://dx.doi.org/10.26828/cannabis.2022.02.000.01.

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Background. There have been notable increases in the use of cannabidiol (CBD) for therapeutic purposes, such as in the treatment of stress- and anxiety- related disorders. Preliminary research has demonstrated that CBD decreases indices of stress and anxiety. However, drug effects in humans are thought to be comprised of both pharmacological properties as well as a placebo response. Little is known about the extent to which the purported therapeutic effects of CBD result from pharmacological versus expectancy factors. Aims. The aim of this study was to evaluate whether (i) CBD expectancy alone

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Consumi, Vanni, Danail Stoyanov, and Agostino Stilli. "Miniaturisation, Modularization and Evaluation of the SoftSCREEN System." In THE HAMLYN SYMPOSIUM ON MEDICAL ROBOTICS. The Hamlyn Centre, Imperial College London London, UK, 2023. http://dx.doi.org/10.31256/hsmr2023.74.

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Early detection of precancerous forms in the intestine, e.g. adenomatous polyps, can be achieved with regular screening programmes of the lower gastro-intestinal tract (GI) by means of flexible sigmoidoscopy and colonoscopy. Screening of the GI tract is of paramount importance to reduce the high death rate of patients affected by colon cancer worldwide. Nonetheless, colonoscopy typi- cally causes discomfort and often requires sedation for the patient because of its invasiveness and abdominal pain as- sociated with it. Research on robotic-assisted colonoscopy is advancing in the design of minim

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