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Journal articles on the topic 'Selection and resistance to new knowledge'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Sierotzki, Helge, and Gabriel Scalliet. "A Review of Current Knowledge of Resistance Aspects for the Next-Generation Succinate Dehydrogenase Inhibitor Fungicides." Phytopathology® 103, no. 9 (2013): 880–87. http://dx.doi.org/10.1094/phyto-01-13-0009-rvw.

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The new broad-spectrum fungicides from the succinate dehydrogenase inhibitor (SDHI) class have been quickly adopted by the market, which may lead to a high selection pressure on various pathogens. Cases of resistance have been observed in 14 fungal pathogens to date and are caused by different mutations in genes encoding the molecular target of SDHIs, which is the mitochondrial succinate dehydrogenase (SDH) enzyme. All of the 17 marketed SDHI fungicides bind to the same ubiquinone binding site of the SDH enzyme. Their primary biochemical mode of action is the blockage of the TCA cycle at the l

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Sadjere, E. G., and Godfrey Omonefe Ariavie. "Metallurgy of Steel Selection in Components Design: Micro-Constituents and Alloying." Advanced Materials Research 824 (September 2013): 354–62. http://dx.doi.org/10.4028/www.scientific.net/amr.824.354.

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The design engineer is daily confronted with the need for materials to meet design requirements of strength, stiffness, toughness, wear-resistance, corrosion-resistance, high-temperature operation and so on. Steel is the most versatile material and can be made into various forms, types or grades and possesses diverse mechanical properties that made it suitable for different uses. Through the study of the metallurgy of steel, steels are standardized into groups according to their composition, characteristics and uses derived from the types, sizes and dispersion of micro-constituents. The knowle

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Fan, Jiangbin, Jörg Wennmann, and Johannes Jehle. "Partial Loss of Inheritable Type I Resistance of Codling Moth to Cydia pomonella granulovirus." Viruses 11, no. 6 (2019): 570. http://dx.doi.org/10.3390/v11060570.

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Current knowledge of the field resistance of codling moth (CM, Cydia pomonella, L) against Cydia pomonella granulovirus (CpGV) is based mainly on the interaction between the Mexican isolate CpGV-M and CpRR1, a genetically homogeneous CM inbreed line carrying type I resistance. The resistance level of laboratory-reared CpRR1 to CpGV-M was recently found to have decreased considerably, compared to the initially high resistance. To understand the background of this phenomenon, CpRR1 larvae were exposed over several generations to CpGV-M for re-selection of the original resistance level. After fiv

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Federico, Piera, Emilio Francesco Giunta, Andrea Tufo, Francesco Tovoli, Angelica Petrillo, and Bruno Daniele. "Resistance to Antiangiogenic Therapy in Hepatocellular Carcinoma: From Molecular Mechanisms to Clinical Impact." Cancers 14, no. 24 (2022): 6245. http://dx.doi.org/10.3390/cancers14246245.

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Antiangiogenic drugs were the only mainstay of advanced hepatocellular carcinoma (HCC) treatment from 2007 to 2017. However, primary or secondary resistance hampered their efficacy. Primary resistance could be due to different molecular and/or genetic characteristics of HCC and their knowledge would clarify the optimal treatment approach in each patient. Several molecular mechanisms responsible for secondary resistance have been discovered over the last few years; they represent potential targets for new specific drugs. In this light, the advent of checkpoint inhibitors (ICIs) has been a new o

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McDonald, B. A., and C. Linde. "Disease resistance and pathogen population genetic." Plant Protection Science 38, SI 1 - 6th Conf EFPP 2002 (2002): 245–48. http://dx.doi.org/10.17221/10375-pps.

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Plant pathologists have seen many boom-and-bust cycles following the deployment of resistant varieties. These cycles result when pathogen populations adapt to the presence of a major resistance gene by evolving a new population that can overcome this resistance gene. The breakdown of genetic resistance is due to the evolution of the local pathogen population because of selection for mutants, recombinants, or immigrants that are better adapted to the resistant cultivar. To understand the process that leads to breakdown of a resistance gene, we need to understand the processes that govern pathog

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Harker, K. N. "Slowing weed evolution with integrated weed management." Canadian Journal of Plant Science 93, no. 5 (2013): 759–64. http://dx.doi.org/10.4141/cjps2013-049.

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Harker, K. N. 2013. Slowing weed evolution with integrated weed management. Can. J. Plant Sci. 93: 759–764. For millennia, weeds have slowly evolved in response to ever-changing environments and crop production practices. Weeds are now evolving much more quickly due to consistently repeated cropping systems and intense herbicide selection pressures. Weed resistance to herbicides now threatens cropping system sustainability in several industrialized nations. Integrated weed management (IWM) provides opportunities to reduce selection pressure for weed resistance while maintaining current crop yi

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Ong, Faustine, Kunhwa Kim, and Marina Y. Konopleva. "Venetoclax resistance: mechanistic insights and future strategies." Cancer Drug Resistance 5, no. 2 (2022): 380–400. http://dx.doi.org/10.20517/cdr.2021.125.

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Acute myeloid leukemia (AML) is historically associated with poor prognosis, especially in older AML patients unfit for intensive chemotherapy. The development of Venetoclax, a potent oral BH3 (BCL-2 homology domain 3) mimetic, has transformed the AML treatment. However, the short duration of response and development of resistance remain major concerns. Understanding mechanisms of resistance is pivotal to devising new strategies and designing rational drug combination regimens. In this review, we will provide a comprehensive summary of the known mechanisms of resistance to Venetoclax and discu

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Levchenko, Silivanova, and Shumilova. "CHANGES IN SUSCEPTIBILITIES TO INSECTICIDES IN MUSCA DOMESTICA UNDER SELECTION WITH FIPRONIL." THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL, no. 21 (May 29, 2020): 194–98. http://dx.doi.org/10.31016/978-5-9902341-5-4.2020.21.194-198.

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New knowledge about resistance and cross-resistance to insecticides of different chemical classes in insects is crucial for correct and effective pest management. This paper reports changes in the susceptibility to insecticides of different chemical classes in the first generations of houseflies Musca domestica L. when they were selected with fipronil. The selection of M. domestica was carried out by feeding adult insects with sugar containing fipronil in a dose that causes the 40–60% mortality of insects. The susceptibility of adults and larvae to insecticides was evaluated by the resistance

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Netrebko, Valerii, Vadym Shalomieiev, Serhii Sheiko, Olexandr Shapurov, Oleksii Hrechanyi, and Valentyna Tretiak. "Optimizing Material and Technology Selection for Cost-Effective Equipment Performance." Challenges and Issues of Modern Science 4, no. 1 (2025): 61–68. https://doi.org/10.15421/cims.4.287.

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Purpose. To optimize criteria for evaluating the implementation of wear-resistant materials to reduce production costs and equipment downtime. Design / Method / Approach. The study employed an analytical review of publications, spectral and metallographic analysis of alloys, a gravimetric method for assessing wear resistance, and heat treatment to enhance it. Findings. An analysis of challenges in developing materials for mining, metallurgical, and construction equipment was conducted. It was established that component service life must align with equipment maintenance schedules. New materials

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Burdon, Jeremy J., Jiasui Zhan, Luke G. Barrett, Julien Papaïx, and Peter H. Thrall. "Addressing the Challenges of Pathogen Evolution on the World’s Arable Crops." Phytopathology® 106, no. 10 (2016): 1117–27. http://dx.doi.org/10.1094/phyto-01-16-0036-fi.

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Advances in genomic and molecular technologies coupled with an increasing understanding of the fine structure of many resistance and infectivity genes, have opened up a new era of hope in controlling the many plant pathogens that continue to be a major source of loss in arable crops. Some new approaches are under consideration including the use of nonhost resistance and the targeting of critical developmental constraints. However, the major thrust of these genomic and molecular approaches is to enhance the identification of resistance genes, to increase their ease of manipulation through marke

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Levi, Giovanni. "Violence and Resistance in Cultural Transmission: Generations and Time." Balkanistic Forum 34, no. 1 (2025): 259–72. https://doi.org/10.37708/bf.swu.v34i1.13.

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This essay, or rather incomplete notes, is interested in relations between knowledge and culture, discussing on the negative features aroused not from the production of knowledge itself but in the abusive aspects of its transmission. If knowledge is in continuous and often non-linear development, something with a specific time dependency as well as a fragile and non-permanent legitimacy, while culture is something different, as it is composed of knowledge but also of traditions and behaviours, and is connected with social or ethnic groups preserving values, not scientific in character but havi

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Nyasse, S., I. B. Efombagn Mousseni, and A. B. Eskes. "Selection for resistance to black pod disease and yield gains prediction by use of selected cocoa varieties in Cameroon." Plant Genetic Resources 1, no. 2-3 (2003): 157–60. http://dx.doi.org/10.1079/pgr200323.

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Research on resistance to black pod caused by Phytophthora megakarya has been carried out in Cameroon for 40 years. It has yielded a significant database which is currently being exploited for the modelling of disease resistance levels of the major clones selected as candidate parents for the creation of new resistant and consequently more productive cocoa varieties. These outputs are expected to meet the increasing need of producers for improved planting material to extend cultivation into emerging cocoa-growing areas or to renew old cocoa production basins. These outputs have been made possi

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Seidel, J. P., and B. Collingwood. "A new socket roughness factor for prediction of rock socket shaft resistance." Canadian Geotechnical Journal 38, no. 1 (2001): 138–53. http://dx.doi.org/10.1139/t00-083.

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Prediction of rock socket shaft resistance is a complex problem. Conventional methods for predicting the peak shaft resistance are typically empirically related to unconfined compressive strength through the results of pile load tests. It is shown by reference to international pile socket databases that the degree of confidence which can be applied to these empirical methods is relatively low. Research at Monash University has been directed at understanding and then modelling the complex mechanisms of shear transfer at the interface between the socketed piles and the surrounding rock. Importan

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Demenkov, P. S., O. V. Saik, T. V. Ivanisenko, N. A. Kolchanov, A. V. Kochetov, and V. A. Ivanisenko. "Prioritization of potato genes involved in the formation of agronomically valuable traits using the SOLANUM TUBEROSUM knowledge base." Vavilov Journal of Genetics and Breeding 23, no. 3 (2019): 312–19. http://dx.doi.org/10.18699/vj19.501.

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The development of highly efficient technologies in genomics, transcriptomics, proteomics and metabolomics, as well as new technologies in agriculture has led to an “information explosion” in plant biology and crop production, including potato production. Only a small part of the information reaches formalized databases (for example, Uniprot, NCBI Gene, BioGRID, IntAct, etc.). One of the main sources of reliable biological data is the scientific literature. The well-known PubMed database contains more than 18 thousand abstracts of articles on potato. The effective use of knowledge presented in

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15

Edward, Dominic A., Claudia Fricke, and Tracey Chapman. "Adaptations to sexual selection and sexual conflict: insights from experimental evolution and artificial selection." Philosophical Transactions of the Royal Society B: Biological Sciences 365, no. 1552 (2010): 2541–48. http://dx.doi.org/10.1098/rstb.2010.0027.

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Artificial selection and experimental evolution document natural selection under controlled conditions. Collectively, these techniques are continuing to provide fresh and important insights into the genetic basis of evolutionary change, and are now being employed to investigate mating behaviour. Here, we focus on how selection techniques can reveal the genetic basis of post-mating adaptations to sexual selection and sexual conflict. Alteration of the operational sex ratio of adult Drosophila over just a few tens of generations can lead to altered ejaculate allocation patterns and the evolution

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Dekkers, Jack C. "48 The impact of new technologies on livestock breeding; what’s next?" Journal of Animal Science 97, Supplement_3 (2019): 53. http://dx.doi.org/10.1093/jas/skz258.107.

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Abstract Over the past decade, genomics has had tremendous impact on livestock breeding through genomic selection, which allows genetic gain based on available phenotypic records to be improved by leveraging information contained in a phenotype across all selection candidates at an early age, rather than only across close relatives. Apart from increasing and optimizing size and structure of training data, further improvement of genomic selection requires information on QTL, in order to reduce the “data noise” that is created by uninformative SNPs. Gene editing provides additional opportunities

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Tyshchenko, Andrii, Olena Tyshchenko, Vira Konovalova, Kateryna Fundirat, and Olena Piliarska. "Methods of determining the adaptability and ecological stability of plants." InterConf, no. 33(155) (May 19, 2023): 324–42. http://dx.doi.org/10.51582/interconf.19-20.05.2023.029.

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Resistance to stress factors is of great natural and ecological importance, since the ability of plants to adapt to the conditions of existence is one of the factors that determines the range of distribution of species and cultures. In this regard, there is a growing need for an accurate assessment of the adaptive potential of plants, which is impossible without studying the physiological bases of their resistance and developing agrotechnical, selection-genetic, and genetic engineering methods for increasing the resistance of cultivated plants to abiotic stresses using new fundamental knowledg

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18

Semenkov, Vadim E. "The Political Economy of useful knowledge of Joel Mokyr." Bulletin of the Far Eastern Federal University. Economics and Management, no. 3 (75) (December 30, 2015): 81–96. https://doi.org/10.5281/zenodo.46052.

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The article outlines the main provisions of the new work on the knowledge economy of contemporary American scholar Joel Mokyr. In "The Gifts of Athena" Joel Mokyr argues that rapid economic growth in the West over the past two centuries has been associated not only with the advent of modern technical ideas, but also with a significant improvement in access to these ideas in society. This access expansion was made possible by access to social networks consisting of universities, publishing houses, clubs of specialists engineers, etc.

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Zhurilo, A. A., and A. I. Barbova. "KNOWN MECHANISMS OF M. TUBERCULOSIS DRUG RESISTANCE TO MAJOR FIRST AND SECOND LINE ANTIMYCOBACTERIAL DRUGS." Ukrainian Pulmonology Journal 31, no. 4 (2023): 45–55. http://dx.doi.org/10.31215/2306-4927-2023-31-4-45-55.

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The continued rise in the prevalence of multidrug-resistant and extensively drug-resistant tuberculosis in the era of human immunodeficiency virus infection poses a serious threat to effective tuberculosis control. Drug resistance in M. tuberculosis occurs due to lowfrequency spontaneous chromosomal mutations. The clinical form of drug-resistant tuberculosis occurs mainly as a result of human selection during the treatment period of these genetic rearrangements due to indiscriminate drug provision, suboptimal treatment regimens prescribed by physicians, and poor adherence to treatment by patie

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Cheng, Hans H., Sean MacEachern, Sugalesini Subramaniam, and William M. Muir. "Chicks and single-nucleotide polymorphisms: an entrée into identifying genes conferring disease resistance in chicken." Animal Production Science 52, no. 3 (2012): 151. http://dx.doi.org/10.1071/an11099.

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Marek’s disease (MD) is one of the most serious chronic infectious disease threats to the poultry industry worldwide. Selecting for increased genetic resistance to MD is a control strategy that can augment current vaccinal control measures. Although our previous efforts integrating various genomic screens successfully identified three resistance genes, the main limitation was mapping precision, which hindered our ability to identify and further evaluate high-confidence candidate genes. Towards identifying the remaining genes of this complex trait, we incorporated three additional approaches ma

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Kort, J., and T. J. Blake. "Sap velocity as an indicator of diurnal and long-term hydraulic resistance changes in mature ‘Walker’ hybrid poplar treesThis article is one of a selection of papers published in the Special Issue on Poplar Research in Canada." Canadian Journal of Botany 85, no. 11 (2007): 1033–41. http://dx.doi.org/10.1139/b07-030.

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Hydraulic resistance directly limits sap flow in trees so that understanding water-use patterns in poplar trees requires knowledge about diurnal and long-term changes in resistances in the soil–plant–atmosphere continuum. Granier thermal dissipation probes were used for continuous measurements of sap velocity (V) changes over time and whole-tree water-use patterns in the main stems of ‘Walker’ hybrid poplar trees. When atmospheric demand was low, V depended only on solar radiation (Rg) and vapour pressure difference (VPD). However, on warm, sunny days, midday V decreased, despite a constant le

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Gage, Karla L., and Lauren M. Schwartz-Lazaro. "Shifting the Paradigm: An Ecological Systems Approach to Weed Management." Agriculture 9, no. 8 (2019): 179. http://dx.doi.org/10.3390/agriculture9080179.

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Weeds have been historically, and are still today, the primary and most economically important pest in agriculture. Several selection pressures associated with weed management, such as an overreliance on herbicides, have promoted the rapid evolution of herbicide-resistant weeds. Integrated Weed Management (IWM) is promoted as an ecological systems approach, through the combination of biological, chemical, cultural, ecological, and mechanical control methods. The concept of a systems approach is defined as managing weeds by combining practice and knowledge with the goals of increasing yield and

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Loncar, Dragan. "Postmodern organization and new forms of organizational control." Ekonomski anali 50, no. 165 (2005): 105–20. http://dx.doi.org/10.2298/eka0565105l.

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This article displays post bureaucratic organisational concept as an adequate representative of all emerging organizational forms which are natural result of persistent initiatives to flexibly and intensify working process. Under this term we assume all budding ?sub-representatives' such as Total Quality Management (TQM), Just-in-time concept (JIT), network systems and joint ventures, virtual organizations, teamwork and other related structures. The author concludes that main virtues of new organizational paradigm are flexibility, decentralization, higher employee empowerment, knowledge and in

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Barbey, Christopher R., Seonghee Lee, Sujeet Verma, et al. "Disease Resistance Genetics and Genomics in Octoploid Strawberry." G3: Genes|Genomes|Genetics 9, no. 10 (2019): 3315–32. http://dx.doi.org/10.1534/g3.119.400597.

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Octoploid strawberry (Fragaria ×ananassa) is a valuable specialty crop, but profitable production and availability are threatened by many pathogens. Efforts to identify and introgress useful disease resistance genes (R-genes) in breeding programs are complicated by strawberry’s complex octoploid genome. Recently-developed resources in strawberry, including a complete octoploid reference genome and high-resolution octoploid genotyping, enable new analyses in strawberry disease resistance genetics. This study characterizes the complete R-gene collection in the genomes of commercial octoploid str

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Chyła, Karol, Marcin Urbański, Dominik Sawuła, and Stanisław Rawicki. "Case study of effective current estimation in main circuit of tram vehicle." MATEC Web of Conferences 180 (2018): 02004. http://dx.doi.org/10.1051/matecconf/201818002004.

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Currently the trams are experiencing the renaissance and more and more Polish cities decide to renew the fleet. New vehicles are usually characterized by high transport capacity, low floor, climate comfort, crash resistance, low energy consumption and low axle loads. Such requirements can only be achieved through optimization in many areas of the vehicle's construction. One of such tasks is the optimal selection of components of the main circuit installation and traction needs. The paper is oriented on the issue of engineering modelling of the effective values of currents flowing in the main c

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Badar, Vandana, Vidisha Vivek Parulekar, and Priti Garate. "Study of knowledge, attitude and practice amongst medical professionals about antimicrobial stewardship in tertiary care teaching hospital in India: a questionnaire based study." International Journal of Basic & Clinical Pharmacology 7, no. 3 (2018): 511. http://dx.doi.org/10.18203/2319-2003.ijbcp20180666.

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Background: Appropriate selection of antimicrobial drugs is critical to optimize treatment of infections ad limit the spread of antimicrobial resistance. Antimicrobial resistance is a serious global problem of antimicrobial abuse and there is a growing consensus to urgently develop new strategies for prevention of resistance of bacteria to antimicrobial agents. Relatively few studies of knowledge, attitude and practice are published regarding antimicrobial resistance.Methods: To explore the perceptions of knowledge, attitude and practice of antimicrobial agent use and its resistance in medical

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PRICHARD, R. K., G. von SAMSON-HIMMELSTJERNA, W. J. BLACKHALL, and T. G. GEARY. "Foreword: Towards markers for anthelmintic resistance in helminths of importance in animal and human health." Parasitology 134, no. 8 (2007): 1073–76. http://dx.doi.org/10.1017/s0031182007000078.

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SUMMARYAnthelmintic resistance is a serious problem in veterinary medicine and appears to be developing in some helminths of importance to human health. Anthelmintic drugs remain the principal means of control of helminth infections in animals and humans and the continued dependence on these pharmaceuticals will continue to impose selection pressure for resistance development. Our ability to detect anthelmintic resistance before control breaks down and to monitor the spread of anthelmintic resistance is quite limited. We are currently dependent on biological methods which are not sufficiently

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Pantchev, I., S. Aziz, F. Sarsu, and N. Tomlekova. "Applicability of ISAP, ISSR and SSR markers in tomato breeding programs." Vegetable crops of Russia, no. 6 (December 18, 2019): 24–26. http://dx.doi.org/10.18619/2072-9146-2019-6-24-26.

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Domesticated crops are characterized by narrow genetic base reflecting one or more bottlenecks during millennia-long selection. As a result, current breeding programs are limited in available germplasm and are forced to deal with incremental improvements of yield, resistance, nutritional value, etc. Since the establishment of modern genetics and biotechnology, several new approaches have emerged to extend the genetic base and germplasm improvement. Among these methods, induced mutagenesis appeared as most useful conventional breeding tool. Although, its successful application currently require

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Fairlamb, Alan H. "Metabolic pathway analysis in trypanosomes and malaria parasites." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 357, no. 1417 (2002): 101–7. http://dx.doi.org/10.1098/rstb.2001.1040.

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Identification of novel drug targets is required for the development of new classes of drugs to overcome drug resistance and replace less efficacious treatments. In theory, knowledge of the entire genome of a pathogen identifies every potential drug target in any given microbe. In practice, the sheer complexity and the inadequate or inaccurate annotation of genomic information makes target identification and selection somewhat more difficult. Analysis of metabolic pathways provides a useful conceptual framework for the identification of potential drug targets and also for improving our underst

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Fazio, Gennaro, and Terence Robinson. "Guiding principles in the Geneva® apple rootstock breeding program." Italus Hortus 31, no. 1 (2024): 28. http://dx.doi.org/10.26353/j.itahort/2024.1.2742.

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The Geneva® apple rootstock breeding program has been operating for more than 50 years and through a rigorous breeding and selection process has released several rootstocks that have provided solutions for some of the major rootstock related problems faced by the apple industry worldwide. Research and development for new apple rootstocks encompasses diverse disciplines and research areas including plant physiology, genetics, genomics, transcriptomics, horticulture, and economics. The process of developing the plan for developing new apple rootstocks and related knowledge base is guided by grow

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Wilson, Lewis, Sharon Downes, Moazzem Khan, et al. "IPM in the transgenic era: a review of the challenges from emerging pests in Australian cotton systems." Crop and Pasture Science 64, no. 8 (2013): 737. http://dx.doi.org/10.1071/cp13070.

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The Cotton Catchment Communities Cooperative Research Centre began during a period of rapid uptake of Bollgard II® cotton, which contains genes to express two Bt proteins that control the primary pests of cotton in Australia, Helicoverpa armigera and H. punctigera. The dramatic uptake of this technology presumably resulted in strong selection pressure for resistance in Helicoverpa spp. against the Bt proteins. The discovery of higher than expected levels of resistance in both species against one of the proteins in Bollgard II® cotton (Cry2Ab) led to significant re-evaluation of the resistance

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Lucas, Eric R., Sanjay C. Nagi, Bilali Kabula, et al. "Copy number variants underlie major selective sweeps in insecticide resistance genes in Anopheles arabiensis." PLOS Biology 22, no. 12 (2024): e3002898. https://doi.org/10.1371/journal.pbio.3002898.

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To keep ahead of the evolution of resistance to insecticides in mosquitoes, national malaria control programmes must make use of a range of insecticides, both old and new, while monitoring resistance mechanisms. The outdoor-biting malaria vector Anopheles arabiensis is of increasing concern for malaria transmission because it is apparently less susceptible to many indoor control interventions, yet knowledge of its mechanisms of resistance remains limited. Furthermore, comparatively little is known in general about resistance to non-pyrethroid insecticides such as pirimiphos-methyl (PM), which

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Arca-Suárez, Jorge, Juan Carlos Vázquez-Ucha, Pablo Arturo Fraile-Ribot, et al. "Molecular and biochemical insights into the in vivo evolution of AmpC-mediated resistance to ceftolozane/tazobactam during treatment of an MDR Pseudomonas aeruginosa infection." Journal of Antimicrobial Chemotherapy 75, no. 11 (2020): 3209–17. http://dx.doi.org/10.1093/jac/dkaa291.

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Abstract Background Pseudomonas aeruginosa may develop resistance to novel cephalosporin/β-lactamase inhibitor combinations during therapy through the acquisition of structural mutations in AmpC. Objectives To describe the molecular and biochemical mechanisms involved in the development of resistance to ceftolozane/tazobactam in vivo through the selection and overproduction of a novel AmpC variant, designated PDC-315. Methods Paired susceptible/resistant isolates obtained before and during ceftolozane/tazobactam treatment were evaluated. MICs were determined by broth microdilution. Mutational

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Kaigorodova, I. M., I. P. Kotlyar, V. A. Ushakov, I. A. Engalycheva, and E. G. Kozar. "Priority directions of modern breeding of vegetable peas (<i>Pisum sativum</i> L.)." Vegetable crops of Russia, no. 4 (July 18, 2023): 5–12. http://dx.doi.org/10.18619/2072-9146-2023-4-5-12.

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Over the years, breeders around the world have made significant changes to the architecture of plants of vegetable pea varieties. The changes made were aimed at increasing, first of all, the yield. New varieties should have an optimal combination of plant height, the number of productive nodes and increased resistance to lodging. Having achieved certain results, breeders find ways to improve the culture, further improving its economically valuable features. The article highlights the priority directions in the selection of vegetable peas in the Federal State Budgetary Scientific Institution «F

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Huang, Minghui, Ruifeng Qin, Chunjie Li, et al. "Response of soybean genotypes from Northeast China to Heterodera glycines races 4 and 5, and characterisation of rhg1 and Rhg4 genes for soybean resistance." Nematology 24, no. 3 (2021): 333–45. http://dx.doi.org/10.1163/15685411-bja10134.

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Summary Soybean cyst nematode (SCN, Heterodera glycines) is a devastating plant-parasitic nematode worldwide. Two SCN races, race 4 (HG Type 1.2.3.5.6.7) and race 5 (HG Type 2.5.7), with increased virulence were previously identified in Northeast China. To obtain new resistance sources to these SCN populations, the response of 62 genotypes, including 51 local varieties and breeding lines, and 11 indicator lines for SCN race and HG Type identification, were evaluated. Four new primers in the regions of two loci of GmSHMT08 (Rhg4) and GmSNAP18 (rhg1) were designed for PCR amplification and subse

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Linder, Robert A., Fabian Seidl, Kimberly Ha, and Ian M. Ehrenreich. "The complex genetic and molecular basis of a model quantitative trait." Molecular Biology of the Cell 27, no. 1 (2016): 209–18. http://dx.doi.org/10.1091/mbc.e15-06-0408.

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Quantitative traits are often influenced by many loci with small effects. Identifying most of these loci and resolving them to specific genes or genetic variants is challenging. Yet, achieving such a detailed understanding of quantitative traits is important, as it can improve our knowledge of the genetic and molecular basis of heritable phenotypic variation. In this study, we use a genetic mapping strategy that involves recurrent backcrossing with phenotypic selection to obtain new insights into an ecologically, industrially, and medically relevant quantitative trait—tolerance of oxidative st

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Paynter, Michelle L., Joanne De Faveri, and Mark E. Herrington. "Resistance to Fusarium oxysporum f. sp. fragariae and Predicted Breeding Values in Strawberry." Journal of the American Society for Horticultural Science 139, no. 2 (2014): 178–84. http://dx.doi.org/10.21273/jashs.139.2.178.

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Fusarium wilt of strawberry, incited by Fusarium oxysporum f. sp. fragariae (Fof), is a major disease of the cultivated strawberry (Fragaria ×ananassa) worldwide. An increase in disease outbreaks of the pathogen in Western Australia and Queensland plus the search for alternative disease management strategies place emphasis on the development of resistant cultivars. In response, a partial incomplete diallel cross involving four parents was performed for use in glasshouse resistance screenings. The resulting progeny were evaluated for their susceptibility to Fof. Best-performing progeny and suit

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Gureeva, E. V. "Скрининг коллекционных образцов сои по скороспелости и продуктивности в условиях Рязанской области". Vestnik APK Verhnevolzh`ia, № 3(47) (14 жовтня 2019): 13–16. http://dx.doi.org/10.35694/yarcx.2019.47.3.003.

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Представлены результаты изучения сортов сои мировой коллекции ВИР в условиях Рязанской области в 2015 2018 гг. Целью исследований является изучение коллекционного материала сои в условиях Рязанской области и выявление скороспелых и высокопродуктивных образцов, адаптированных к условиям Центрального региона России. В коллекционном питомнике изучалось 224 образца сои из 30 стран, в т.ч. 52 сортов отечественной селекции. Ежегодно самыми скороспелыми сортами были сорта российской селекции Эльдорадо, СибНИИК315, Касатка, Светлая сорта шведской селекции Brawalla и 1384 и сорт Прогресс (Польша). Уста

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Papp, Márton, and Norbert Solymosi. "Review and Comparison of Antimicrobial Resistance Gene Databases." Antibiotics 11, no. 3 (2022): 339. http://dx.doi.org/10.3390/antibiotics11030339.

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As the prevalence of antimicrobial resistance genes is increasing in microbes, we are facing the return of the pre-antibiotic era. Consecutively, the number of studies concerning antibiotic resistance and its spread in the environment is rapidly growing. Next generation sequencing technologies are widespread used in many areas of biological research and antibiotic resistance is no exception. For the rapid annotation of whole genome sequencing and metagenomic results considering antibiotic resistance, several tools and data resources were developed. These databases, however, can differ fundamen

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Liu, Gang, Line Elnif Thomsen, and John Elmerdahl Olsen. "Antimicrobial-induced horizontal transfer of antimicrobial resistance genes in bacteria: a mini-review." Journal of Antimicrobial Chemotherapy 77, no. 3 (2021): 556–67. http://dx.doi.org/10.1093/jac/dkab450.

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Abstract The emergence and spread of antimicrobial resistance (AMR) among pathogenic bacteria constitute an accelerating crisis for public health. The selective pressures caused by increased use and misuse of antimicrobials in medicine and livestock production have accelerated the overall selection of resistant bacteria. In addition, horizontal gene transfer (HGT) plays an important role in the spread of resistance genes, for example mobilizing reservoirs of AMR from commensal bacteria into pathogenic ones. Antimicrobials, besides antibacterial function, also result in undesirable effects in t

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Dietrich, D., W. Förster, C. Eßbach, P. Neumann, and D. Nickel. "Selection of carbon particles with different shape, size and concentration as additives in a stereolithographic resin." Materialwissenschaft und Werkstofftechnik 56, no. 1 (2025): 8–16. https://doi.org/10.1002/mawe.202300370.

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AbstractStereolithography (SLA) as one of the additive manufacturing processes provides new approaches towards high design flexibility and fast prototyping. In the last years, the variety of different resins is highly enhanced towards polymers that meet high requirements – mechanical, optical and thermal properties as well as electroconductivity. To our knowledge, direct electroplating is not investigated so far. The aim of our work is the development of a composite material that is able to be processed by stereolithography and that provides the electroconductivity for direct electroplating. D

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Perucca, Emilio. "Antiepileptic drugs: evolution of our knowledge and changes in drug trials." Epileptic Disorders 21, no. 4 (2019): 319–29. http://dx.doi.org/10.1684/epd.2019.1083.

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ABSTRACT Clinical trials provide the evidence needed for rational use of medicines. The evolution of drug trials follows largely the evolution of regulatory requirements. This article summarizes methodological changes in antiepileptic drug trials and associated advances in knowledge starting from 1938, the year phenytoin was introduced and also the year when evidence of safety was made a requirement for the marketing of medicines in the United States. The first period (1938–1969) saw the introduction of over 20 new drugs for epilepsy, many of which did not withstand the test of time. Only few

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Jekunen, Antti P. "Role of Rebiopsy in Relapsed Non-Small Cell Lung Cancer for Directing Oncology Treatments." Journal of Oncology 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/809835.

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Background.Currently, few rebiopsies are performed in relapses of advanced non-small cell lung cancer. They are not customary in clinical practice of lung cancer. However, it is not possible to properly target treatments in cases of relapse without knowing the nature of new lesions.Design.This paper comprehensively summarizes the available literature about rebiopsy and broadly discusses the importance of rebiopsy in advanced non-small cell lung cancer.Results.Altogether 560 abstracts were used as material for further analysis. 19 articles were about clinical rebiopsy in lung cancer and were re

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Ramasco, Fernando, Rosa Méndez, Alejandro Suarez de la Rica, Rafael González de Castro, and Emilio Maseda. "Sepsis Stewardship: The Puzzle of Antibiotic Therapy in the Context of Individualization of Decision Making." Journal of Personalized Medicine 14, no. 1 (2024): 106. http://dx.doi.org/10.3390/jpm14010106.

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The main recent change observed in the field of critical patient infection has been universal awareness of the need to make better use of antimicrobials, especially for the most serious cases, beyond the application of simple and effective formulas or rigid protocols. The increase in resistant microorganisms, the quantitative increase in major surgeries and interventional procedures in the highest risk patients, and the appearance of a significant number of new antibiotics in recent years (some very specifically directed against certain mechanisms of resistance and others with a broader spectr

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Petrovic, M. M., S. Aleksic, M. P. Petrovic, et al. "Potentials of Serbian livestock production: Outlook and future." Biotehnologija u stocarstvu 29, no. 1 (2013): 1–17. http://dx.doi.org/10.2298/bah1301001p.

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The paper describes the state of the livestock production in the Republic of Serbia including preliminary results from the 2012 census: according to preliminary data, 908.990 heads of cattle, 3.403.288 pigs, 1.729.278 sheep and 235.576 goats are reared in Serbia. Structural and institutional measures, and measures of credit support should be the main instruments for achieving the goals of progress in animal husbandry. Activities in the breeding-selection work should be carried out in accordance with the recommendations of international organizations (ICAR, INTERBULL, EAAP). One of the most imp

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Dashtbani-Roozbehani, Abolfazl, and Melissa H. Brown. "Efflux Pump Mediated Antimicrobial Resistance by Staphylococci in Health-Related Environments: Challenges and the Quest for Inhibition." Antibiotics 10, no. 12 (2021): 1502. http://dx.doi.org/10.3390/antibiotics10121502.

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The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major health threat worldwide due to significant morbidity and mortality resulting from their associated hospital- or community-acquired infections. Dramatic decrease in the discovery of new antibiotics from the pharmaceutical industry coupled with increased use of sanitisers and disinfectants due to the ongoing COVID-19 pandemic can further aggravate the problem of antimicrobial resistance. Staphylococci utilise multiple mechanisms to circumvent the effects of antimicrobials. One of these resistance mechanism

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Olbryt, Magdalena. "Potential Biomarkers of Skin Melanoma Resistance to Targeted Therapy—Present State and Perspectives." Cancers 14, no. 9 (2022): 2315. http://dx.doi.org/10.3390/cancers14092315.

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Melanoma is the most aggressive skin cancer, the number of which is increasing worldwide every year. It is completely curable in its early stage and fatal when spread to distant organs. In addition to new therapeutic strategies, biomarkers are an important element in the successful fight against this cancer. At present, biomarkers are mainly used in diagnostics. Some biological indicators also allow the estimation of the patient’s prognosis. Still, predictive markers are underrepresented in clinics. Currently, the only such indicator is the presence of the V600E mutation in the BRAF gene in ca

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López Romo, Alicia, and Rodolfo Quirós. "Appropriate use of antibiotics: an unmet need." Therapeutic Advances in Urology 11 (January 2019): 175628721983217. http://dx.doi.org/10.1177/1756287219832174.

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Increasing bacterial resistance combined with a steady decline in the discovery of new antibiotics has resulted in a global healthcare crisis. Overuse of antibiotics, for example, in the poultry and cattle industry, and misuse and improper prescription of antibiotics are leading causes of multidrug resistance (MDR). The increasing use of antibiotics, particularly in developing countries, is a big concern for antibiotic resistance and can cause other health threats such as increased risk of recurrent infections and increased risk of cardiovascular death with chronic use of macrolides. Carbapene

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Sambu, Sammy. "TAS2R Receptor Response Helps Design New Antimicrobial Molecules for the 21st Century." ChemEngineering 8, no. 5 (2024): 96. http://dx.doi.org/10.3390/chemengineering8050096.

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Artificial intelligence (AI) requires the provision of learnable data to successfully deliver requisite prediction power. In this article, it is demonstrable that standard physico-chemical parameters, while useful, are insufficient for the development of powerful antimicrobial prediction algorithms. Initial models that focussed solely on the values extractable from the knowledge on electrotopological, structural and constitutional descriptors did not meet the acceptance criteria for classifying antimicrobial activity. In contrast, efforts to conceptually define the diametric opposite of an ant

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Sant, Marta, Adrià Bernat-Peguera, Eudald Felip, and Mireia Margelí. "Role of ctDNA in Breast Cancer." Cancers 14, no. 2 (2022): 310. http://dx.doi.org/10.3390/cancers14020310.

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Breast cancer is currently classified by immunohistochemistry. However, technological advances in the detection of circulating tumor DNA (ctDNA) have made new options available for diagnosis, classification, biological knowledge, and treatment selection. Breast cancer is a heterogeneous disease and ctDNA can accurately reflect this heterogeneity, allowing us to detect, monitor, and understand the evolution of the disease. Breast cancer patients have higher levels of circulating DNA than healthy subjects, and ctDNA can be used for different objectives at different timepoints of the disease, ran

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