Relevant bibliographies by topics / Selective thrombolysis

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Selective thrombolysis'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Selective thrombolysis"

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Earnshaw, J. J., and P. Birch. "Peripheral Thrombolysis: State of the Art." Cardiovascular Surgery 3, no. 4 (1995): 357–67. http://dx.doi.org/10.1177/096721099500300402.

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Peripheral thrombolysis has become established in the last decade as an alternative method of treatment for acute limb ischaemia. New techniques of accelerated thrombolysis have expanded the indications to include almost all affected patients. Attention to detail and avoidance of known pitfalls, together with close cooperation between vascular surgeon and radiologist, ensure optimum results with minimum complications. A modern integrated lysis programme may vary from initial thrombolytic treatment for all patients with acute limb ischaemia to a selective policy of surgery and thrombolysis depe
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Igor, B. Kovalenko* Zhanna Yu. Chefranova Nadezhda S. Zueva Vyacheslav D. Polyansky. "APPLICATION OF SELECTIVE THROMBOLYTIC THERAPY FOR ISCHEMIC STROKE TREATMENT." Indo American Journal of Pharmaceutical Sciences 04, no. 10 (2017): 3727–31. https://doi.org/10.5281/zenodo.1019479.

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The article deals with the review and analysis of the major study related to both applications of STLT and that compared to systemic thrombolysis which demonstrate good functional results after 90 days of STLT application and less number of intracranial hemorrhage during 24 hours. The comparative analysis of the outcomes of ischemic stroke treatment based on systemic and selective thrombolysis by Actilyse was conducted in Belgorod Regional Clinical Hospital. The procedure of selective thrombolysis was described. The analysis of the effectiveness and complications depending on medication dose a
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Park, Jae Hyung, Kil Sun Park, Jin Wook Chung, Joon Koo Han, Dae Young Kim, and Sang Joon Kim. "Selective arterial thrombolysis with urokinase." Journal of the Korean Radiological Society 27, no. 4 (1991): 441. http://dx.doi.org/10.3348/jkrs.1991.27.4.441.

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Huang, Yu, Boram Gu, Isabelle I. Salles-Crawley, et al. "Fibrinogen-mimicking, multiarm nanovesicles for human thrombus-specific delivery of tissue plasminogen activator and targeted thrombolytic therapy." Science Advances 7, no. 23 (2021): eabf9033. http://dx.doi.org/10.1126/sciadv.abf9033.

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Clinical use of tissue plasminogen activator (tPA) in thrombolytic therapy is limited by its short circulation time and hemorrhagic side effects. Inspired by fibrinogen binding to activated platelets, we report a fibrinogen-mimicking, multiarm nanovesicle for thrombus-specific tPA delivery and targeted thrombolysis. This biomimetic system is based on the lipid nanovesicle coated with polyethylene glycol (PEG) terminally conjugated with a cyclic RGD (cRGD) peptide. Our experiments with human blood demonstrated its highly selective binding to activated platelets and efficient tPA release at a th
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Duraes, Andre R., and Jose C. Brito. "Selective Intraarterial Thrombolysis for Cardioembolic Stroke." New England Journal of Medicine 367, no. 17 (2012): e24. http://dx.doi.org/10.1056/nejmicm1211164.

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Witt, W., B. Baldus, P. Bringmann, L. Cashion, P. Donner, and WD Schleuning. "Thrombolytic properties of Desmodus rotundus (vampire bat) salivary plasminogen activator in experimental pulmonary embolism in rats." Blood 79, no. 5 (1992): 1213–17. http://dx.doi.org/10.1182/blood.v79.5.1213.1213.

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Abstract rDSPA alpha 1 (recombinant Desmodus salivary plasminogen activator alpha 1) is a recombinant protein corresponding to a natural plasminogen activator from the vampire bat Desmodus rotundus. The thrombolytic properties of rDSPA alpha 1 and tissue-type plasminogen activator (t-PA) were compared in a rat model of pulmonary embolism. Whole blood clots, produced in vitro and labeled with 125I-fibrinogen, were embolized into the lungs of anesthetized rats. Thrombolysis was calculated from the difference between initial clot radioactivity and that remaining in the lungs at 60 minutes. Blood
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Witt, W., B. Baldus, P. Bringmann, L. Cashion, P. Donner, and WD Schleuning. "Thrombolytic properties of Desmodus rotundus (vampire bat) salivary plasminogen activator in experimental pulmonary embolism in rats." Blood 79, no. 5 (1992): 1213–17. http://dx.doi.org/10.1182/blood.v79.5.1213.bloodjournal7951213.

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rDSPA alpha 1 (recombinant Desmodus salivary plasminogen activator alpha 1) is a recombinant protein corresponding to a natural plasminogen activator from the vampire bat Desmodus rotundus. The thrombolytic properties of rDSPA alpha 1 and tissue-type plasminogen activator (t-PA) were compared in a rat model of pulmonary embolism. Whole blood clots, produced in vitro and labeled with 125I-fibrinogen, were embolized into the lungs of anesthetized rats. Thrombolysis was calculated from the difference between initial clot radioactivity and that remaining in the lungs at 60 minutes. Blood was sampl
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Pyatikop, V. O., Yu O. Kotlyarevsky, and Yu G. Sergienko. "Our experience in using of intravascular recanalization methods for treatment of acute ischemic stroke." Endovascular Neuroradiology 32, no. 2 (2020): 67–78. http://dx.doi.org/10.26683/2304-9359-2020-2(32)-67-78.

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Objective ‒ to evaluate results of the introduction of intravascular recanalization in the provision of emergency care to patients with ischemic stroke.Materials and methods. The experience of intraarterial thrombolysis on the example of 25 clinical cases was analysed. In 22 patients was performed selective intra-arterial thrombolysis, in 3 cases ‒ with thrombaspiration. All patients had a severe stroke, ranging from 15 to 25 points NIHSS. Confirmation of the diagnosis was performed according to computed tomography scan), ultrasound of the precerebral and cerebral arteries. Selective cerebral
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Dong, Ningzheng, Valdeci Da Cunha, Andrej Citkowicz та ін. "P-selectin-targeting of the fibrin selective thrombolytic Desmodus rotundus salivary plasminogen activator α1". Thrombosis and Haemostasis 92, № 11 (2004): 956–65. http://dx.doi.org/10.1160/th04-03-0177.

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SummaryDuring thrombosis, P-selectin is expressed on the surface of activated endothelial cells and platelets. We hypothesized that targeting a plasminogen activator (PA) to P-selectin would enhance local thrombolysis and reduce bleeding risk. Previously, a urokinase (uPA)/anti-P-selectin antibody (HuSZ51) fusion protein was shown to increase fibrinolysis in a hamster pulmonary embolism model. To explore the therapeutic potential of this targeting strategy, we fused the fibrin-selective Desmodus rotundus salivary PA α1 (dsPAα1) to HuSZ51 and compared the fibrinolytic activity of P-selectin-tar
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Loscalzo, J., T. P. Wharton, J. M. Kirshenbaum, et al. "Clot-selective coronary thrombolysis with pro-urokinase." Circulation 79, no. 4 (1989): 776–82. http://dx.doi.org/10.1161/01.cir.79.4.776.

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Dissertations / Theses on the topic "Selective thrombolysis"

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Tian, Huiqiao. "Multimodal computed tomography in patient selection for acute ischemic stroke intervention." Thesis, 2019. http://hdl.handle.net/1959.13/1408713.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Background: Multimodal computed tomographic (CT) imaging for acute ischemic stroke patients being considered for therapy has been the focus of an increasing body of research over the past decade. The impact of this research has been an increasing use of multimodal CT for individual patient management in acute ischemic stroke by, for example, by excluding hemorrhages from therapy, assisting the treatment decision making process for neurologists or providing useful information to prediction patient outcomes and inform patient family discussions.
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Books on the topic "Selective thrombolysis"

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Lorenzano, Svetlana, and Danilo Toni. Acute treatment. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198722366.003.0014.

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Young adults may benefit from intravenous thrombolysis with tissue plasminogen activator and the treatment is safe. Several important outcome predictors have been identified and can be used for an optimal selection of eligible patients. Intravenous thrombolysis should not be denied a priori in patients with stroke due to craniocervical artery dissection or illicit drug use, or young menstruating/pregnant women. It is recommended to discuss treatment risks and benefits and decisions should be made on an individual basis. Young patients may benefit from endovascular treatment despite larger infa
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Mayor, Diana, and Michael Tymianski. Neuroprotection for Acute Ischemic Stroke. Edited by David L. Reich, Stephan Mayer, and Suzan Uysal. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190280253.003.0010.

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Acute ischemic stroke (AIS) is the leading cause of acquired neurological disability worldwide. AIS most commonly occurs when a cerebral artery is occluded, leading to irreversible brain injury and neurologic disability. Acute supportive physiological interventions and close monitoring on a stroke unit are beneficial to optimize overall recovery and functional outcome. Phamacological treatment options are limited though as the only FDA-approved therapy for AIS is the thrombolytic agent intravenous recombinant tissue plasminogen activator (Alteplase, rtPA), which improves functional outcome in
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Book chapters on the topic "Selective thrombolysis"

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Zeumer, H., G. Siepmann, M. Müller-Jensen, and H. Goossens-Merkt. "Invasive Imaging Techniques in the Evaluation of Patient Selection and Cerebrovascular Recanalization." In Thrombolytic Therapy in Acute Ischemic Stroke. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76439-4_10.

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Arnold, Alfred E. R., Eric Boersma, Maureen van der Vlugt, and Maarten L. Simoons. "Patient Selection for Thrombolytic Therapy for Evolving Myocardial Infarction." In Developments in Cardiovascular Medicine. Springer US, 1997. http://dx.doi.org/10.1007/978-0-585-33754-8_28.

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Furlan, A. J. "Potential Role of Magnetic Resonance Imaging in Selecting Patients for Thrombolytic Therapy." In Thrombolytic Therapy in Acute Ischemic Stroke II. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-78061-5_28.

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Okada, Y., and G. J. del Zoppo. "The Role of P-Selectin and ICAM-1 During Focal Brain Ischemia/Reperfusion." In Thrombolytic Therapy in Acute Ischemic Stroke III. Springer Japan, 1995. http://dx.doi.org/10.1007/978-4-431-68459-6_2.

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Adam, Zulfiquar, and Mark A. de Belder. "Primary percutaneous coronary intervention for ST elevation myocardial infarction." In Oxford Textbook of Interventional Cardiology. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199569083.003.016.

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One of the first reports on the use of intravenous thrombolysis in the treatment of acute myocardial infarction (AMI) was published 50 years ago when Fletcher and colleagues described the use of intravenous streptokinase to restore the patency of arteries occluded by thrombus. However, it was not until the early 1980s that the real impetus towards the ‘open artery’ concept was realised when an angiographic study defined the high prevalence of total coronary occlusion in the early hours of AMI. By this time, the era of interventional cardiology had begun and in 1978 there had already been pilot
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Çetiner, Mustafa. "Thrombolysis in Acute Stroke." In Cerebrovascular Diseases [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.101252.

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The first step in stroke care is early detection of stroke patients and recanalization of the occluded vessel. Rapid and effective revascularization is the cornerstone of acute ischemic stroke management. Intravenous thrombolysis is the only approved pharmacological reperfusion therapy for patients with acute ischemic stroke. Patient selection criteria based on patient characteristics, time, clinical findings and advanced neuroimaging techniques have positively affected treatment outcomes. Recent studies show that the presence of salvageable brain tissue can extend the treatment window for int
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Zuckerman, Darryl, and Christina Marks. "Arteriography and Endovascular Intervention in the Lungs." In Interventional Radiology, edited by Bradley B. Pua, Anne M. Covey, and David C. Madoff. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190276249.003.0027.

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Massive hemoptysis, which can be caused by a variety of chronic pulmonary diseases, is well-suited to treatment by arterial-directed transcatheter-based therapies. Results after bronchial artery embolization are excellent. Knowledge of the arterial anatomy and pathophysiology is critical to clinical success. Pulmonary embolism is a common entity responsible for over 100,000 deaths in the U.S alone. Understanding cardiopulmonary hemodynamics is helpful in deciding which patients will benefit most from interventional techniques such as catheter-directed thrombolysis and thrombectomy. The role of
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Birns, Jonathan, and Ajay Bhalla. "Management of acute stroke within the stroke pathway and stroke clinics." In Oxford Textbook of Geriatric Medicine. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198701590.003.0119.

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There have been considerable advances in stroke research leading to translation of drug therapy for stroke into the clinical arena. Thrombolysis for ischaemic stroke is a key advance that significantly reduces disability. This has revolutionized the manner in which acute stroke is treated as a medical emergency. The use of advanced imaging techniques and adjuncts to thrombolysis could potentially improve selection of patients who may benefit from reperfusion therapy such as mechanical thrombectomy and allow treatment decisions to be based on individual brain pathophysiology, rather than arbitr
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Birns, Jonathan, and Ajay Bhalla. "Management of acute stroke within the stroke pathway and stroke clinics." In Oxford Textbook of Geriatric Medicine. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198701590.003.0119_update_001.

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There have been considerable advances in stroke research leading to translation of drug therapy for stroke into the clinical arena. Thrombolysis for ischaemic stroke is a key advance that significantly reduces disability. This has revolutionized the manner in which acute stroke is treated as a medical emergency. The use of advanced imaging techniques and adjuncts to thrombolysis could potentially improve selection of patients who may benefit from reperfusion therapy such as mechanical thrombectomy and allow treatment decisions to be based on individual brain pathophysiology, rather than arbitr
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Singh Sidhu, Navdeep, and Sumandeep Kaur. "Thrombolytic Therapy in Pulmonary Thromboembolism." In Pulmonary Embolism [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.100600.

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Acute pulmonary thromboembolism (PE) is a common disorder with significant mortality and morbidity. Timely recognition and prompt therapy of this disorder is essential to prevent adverse consequences. Thrombolytic therapy has an important role in the management of high-risk pulmonary embolism patients, where it can be lifesaving. However, the potential clinical benefit of thrombolytic therapy needs to balanced against the risk of major bleeding associated with the use of these agents. Hence patient selection is of paramount importance in determining the success of this therapy. Management stra
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Conference papers on the topic "Selective thrombolysis"

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Loscalzo, J. "THE EFFICACY AND RELATIVE FIBRIN SELECTIVITY OF PROUROKINASE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643573.

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The use of thrombolytic agents in acute myocardial infarction has gained widespread acceptance as an important early therapeutic option. Acute coronary thrombosis has been found in approximately 80% of patients with acute infarction and the use of standard thrombolytic agents opens these occluded vessels in most cases. Unfortunately, in many individuals standard agents also produce a systemic lytic state with its attendant hemorrhagic complications. Prourokinase (PUK) has been shown to be a relatively fibrin selective thrombolytic agent in vitro owing to its localized conversion to urokinase a
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Momier, P., U. Sigwart, F. Bachmnn, C. Ferret, and L. Kapperiberger. "SYSTEMIC THRCMBOLYSIS WITHIN THE FIRST 3 HOURS OF ACUTE CORONARY THROMBOSIS : APSAC VS STREPTOKINASE : A RAMDCMIZED STUDY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642995.

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Intravenous administration of thrombolytic agents in acute myocardial infarction may be preferable to intracoronary thrombolysis for practiced, reasons and to reduce time to reperfusion. As compared to the streptokinase infusion, the bolus injection of APSAC may be even more rational. We have therefore compared the effects of one intravenous bolus injection of APSAC (30 units in 5 min) to an intravenous injection of streptokinase (1.500.000 units in 60 min) within the first 3 hours (mean 141 min for APSAC and 135 min for streptokinase) after the onset of symptoms associated with acute myocardi
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Finke, U., J. Schneider, E. Friderichs, L. Flohé, and H. Giertz. "MYOCARDIAL SALVAGE BY COMBINED TREATMENT WITH RECOMBINANT SINGLE-CHAIN UROKINASE-TYPE PLASMINOGEN ACTIVATOR AND RECOMBINANT HUMAN SUPEROXIDE DISMUTASE IN A CANINE CORONARY THROMBOSIS MODEL*." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643570.

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Recanalization of thrombotic coronary occlusion with fibrinolytic treatment is a promising approach to salvage jeopardized ischemic myocardium. However, the success of thrombolytic treatment of myocardial infarction may be curtailed by the risk inherent to reperfusion. Cell damage upon reoxygenation after an ischemic period is tentatively attributed to the formation of oxygen-derived free radicals. Improved myocardial salvage is therefore expected from coadministration of a free radical scavenger and fibrinolytic treatment. We tested this hypothesis in a canine model of left anterior circumfle
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Haber, Edgar, Marchall T. Runge, Christoph Bode, Betsy Branscomb, and Janet Schnee. "ANTIBODY TARGETED FIBRINOLYSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643723.

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Chemical conjugates of fibrin-specificantibodies and plasminogen activators. Urokinase or tPA were linked covalently toamonoclonal antibody specific for the amino terminus of the beta chain of human fibrin (59D8) by means of the unidirectionalcross-linking reagent SPDP. The fibrinolytic potency of the conjugates at equal amidolytic activities was compared to the native plasminogen activators in an assay measuring lysis of 1251-fibrin monomer covalently linked to Sepharose CL-4B. Urokinase was least potent, tPA exhibited a 10fold increase in fibrinolysis whereas both the urokinase and tPA antib
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Quertermous, T., J. M. Schnee, M. S. Runge, et al. "EXPRESSION OF A RECOMBINANT ANTIBODY-TARGETED THROMBOLYTIC MOLECULE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644616.

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We have recently shown that targeting tissue-type plasminogen activator (t-PA) by covalent linkage to a fibrin-specific monoclonal antibody (59D8) produces a more potent thrombolytic agent which also induces less fibrinogenolysis. A recombinant molecule encoding a t-PA-59D8 fusion protein was constructed to provide a ready source of this agent for further study, and to allow tailoring of the active moities for maximal activity. DNA sequence coding for the 59D8 heavy chain (HC) antigen combining site was cloned from a lambdaphage library by selection with a joining region probe. Gene segments c
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Fears, R. "THE EFFECT OF HEPARIN AND FIBRIN ON THE ENZYMATIC EFFICIENCIES OF THROMBOLYTICS IN_ VITRO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643032.

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Selective fibrinolysis may be achieved physiologically by the binding of both endogenous plasminogen activator (t-PA) and plasminogen to fibrin. It has been suggested that t-PA may also exhibit fibrin-selectivity when used at therapeutic doses for acute myocardial infarction whereas the other principal thrombo-lytics, urokinase (UK) and streptokinase (SK).plasminogen, are not bound. However, in the present kinetic studies it was found that plasminogen activation by SK.lys-plasminogen was enhanced by soluble fibrin (the effect mainly on Km), the affinity of binding to fibrin was similar to t-PA
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Vaughan, D. E., and J. Loscalzo. "PLATELET DISAGGREGATION IN PLASMA--A NOVEL EFFECT OF TISSUE PLASMINOGEN ACTIVATOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644385.

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Platelet aggregates are thought to play a significant role in many clinically important ischemic vascular events. Recently it has been shown that the platelet surface binds plasminogen and, in so doing, enhances its conversion to plasmin by tissue plasminogen activator (tPA). Since fibrinogen, an alternative substrate for plasmin, serves as the cohesive link among platelets induced to aggregate by a variety of agonists, we hypothesized that the local production of plasmin at the platelet surface may be important in promoting the disaggregation of aggregated platelets. When added to a suspensio
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Angles-Cano, E., R. Pannell, and V. Gurewich. "FIBRIN-BINDING STUDIES OF PRO-UROKINASE (PRO-UK) USING SOLID PHASE FIBRIN PLATES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642904.

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Pro-UK is a single chain urokinase-type plasminogen activator (scu-PA) which has fibrin selective thrombolytic properties. However, quantitative data on pro-UK binding to fibrin and on the mechanism of its fibrin enhanced activation of plasminogen have been difficult to obtain. In the present study, a well defined fibrin network constructed on glutaraldehyde-activated PVC plates (Anal. Biochem. 153 : 201-210, 1986) and highly purified pro-UK (99 % scu-PA) were used. Binding was investigated as follows : varying dilutions of pro-UK in the presence of a trace amount of I-labeled pro-UK in buffer
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