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Journal articles on the topic 'Selenium – Therapeutic use'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Duntas, Leonidas H., and Alicja Hubalewska-Dydejczyk. "Selenium and Inflammation— Potential Use and Future Perspectives." US Endocrinology 11, no. 02 (2015): 97. http://dx.doi.org/10.17925/use.2015.11.02.97.

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The essential trace element selenium (Se) is constitutively incorporated as selenocysteine, in proteins, among others in antioxidative selenoproteins, such as glutathione peroxidase(s) and thioredoxin reductase. Since chronic inflammation is thought to deplete Se stores in the body, Se supplementation should be considered in prolonged inflammatory states, Se being the trace element the most affected in chronic or low-grade inflammation. Se administration might also be beneficial in bacterial and viral diseases as well as metabolic and autoimmune diseases. In order to maintain a Se steady state

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2

Hubalewska-Dydejczyk, Alicja, Leonidas Duntas, and Aleksandra Gilis-Januszewska. "Pregnancy, thyroid, and the potential use of selenium." Hormones 19, no. 1 (2019): 47–53. http://dx.doi.org/10.1007/s42000-019-00144-2.

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Abstract The management of pregnant women is a major concern of health care around the world. There is growing evidence regarding the influence of selenium (Se) on pregnancy and fetus outcomes. However, due to as yet insufficient evidence, lack of measurable markers to assess the effect of Se supplementation on the human metabolism, and Se’s narrow therapeutic index, the majority of experts and the current guidelines published by several scientific societies do not recommend the use of Se in pregnancy and in women of childbearing age. Further research based on well-designed studies, including

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3

Janka, Vašková, Kočan Ladislav, Firment Jozef, and Vaško Ladislav. "Restoration of antioxidant enzymes in the therapeutic use of selenium in septic patients." Wiener klinische Wochenschrift 125, no. 11-12 (2013): 316–25. http://dx.doi.org/10.1007/s00508-013-0371-x.

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4

Achibat, Hanane, Nohad A. AlOmari, Federica Messina, Luca Sancineto, Mostafa Khouili, and Claudio Santi. "Organoselenium Compounds as Phytochemicals from the Natural Kingdom." Natural Product Communications 10, no. 11 (2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001119.

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Selenium is naturally present in soils but it is also produced by pollution from human activities into the environment. Its incorporation into plants affords organoselenium metabolites that, depending on the nature of the molecules and the plant species, can be incorporated into proteins, stored or eliminated by volatilization. The possibility to use the selenium metabolism of some plants as a method for bioremediation and, at the main time, as a source of selenated phytochemicals is here discussed taking into consideration the growing interest in organic selenium derivatives as new potential

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Mirdayani, Eli, Irma M. Puspitasari, Rizky Abdulah, and Anas Surbanas. "Selenium sebagai Suplemen Terapi Kanker: Sebuah Review." Indonesian Journal of Clinical Pharmacy 8, no. 4 (2019): 301. http://dx.doi.org/10.15416/ijcp.2019.8.4.301.

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Selenium merupakan unsur mikronutrien yang penting bagi kesehatan manusia. Di dalam tubuh, selenium tersebar di semua organ dalam bentuk senyawa terkonjugasi protein (selenoprotein). Senyawa selenoprotein setidaknya mengandung selenosistein yang terdiri dari asam amino sistein. Senyawa selenoprotein pada umumnya bersifat antioksidan. Selenium dihubungkan dengan pengaruhnya terhadap kesehatan manusia termasuk beberapa jenis penyakit kanker. Studi penggunaan suplementasi selenium pada terapi kanker dengan radiasi dan kemoterapi menunjukan peningkatan kadar selenium pada plasma, meningkatkan efek

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6

Gong, Guifang, Bailing Fu, Caixin Ying, et al. "Targeted delivery of paclitaxel by functionalized selenium nanoparticles for anticancer therapy through ROS-mediated signaling pathways." RSC Advances 8, no. 70 (2018): 39957–66. http://dx.doi.org/10.1039/c8ra07539e.

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7

Lanzolla, Giulia, Claudio Marcocci, and Michele Marinò. "Oxidative Stress in Graves Disease and Graves Orbitopathy." European Thyroid Journal 9, Suppl. 1 (2020): 40–50. http://dx.doi.org/10.1159/000509615.

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Oxidative stress is involved in the pathogenesis of Graves hyperthyroidism (GH) and Graves orbitopathy (GO) and an antioxidant approach has been proposed for both. In GH, a disbalance of the cell redox state is associated with thyroid hyperfunction and antithyroid medications may reduce oxidative stress. Tissue hypoxia participates in the pathogenesis of GO, and oxygen free radicals are involved in the typical changes of orbital tissues as reported by in vitro and clinical studies. Antioxidant agents, especially selenium, have been proposed as a therapeutic option for GH and GO. A clinical stu

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8

Truong, Linh B., David Medina-Cruz, Ebrahim Mostafavi, and Navid Rabiee. "Selenium Nanomaterials to Combat Antimicrobial Resistance." Molecules 26, no. 12 (2021): 3611. http://dx.doi.org/10.3390/molecules26123611.

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The rise of antimicrobial resistance to antibiotics (AMR) as a healthcare crisis has led to a tremendous social and economic impact, whose damage poses a significant threat to future generations. Current treatments either are less effective or result in further acquired resistance. At the same time, several new antimicrobial discovery approaches are expensive, slow, and relatively poorly equipped for translation into the clinical world. Therefore, the use of nanomaterials is presented as a suitable solution. In particular, this review discusses selenium nanoparticles (SeNPs) as one of the most

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Pillay, Nikita Simone, Aliscia Daniels, and Moganavelli Singh. "Folate-Targeted Transgenic Activity of Dendrimer Functionalized Selenium Nanoparticles In Vitro." International Journal of Molecular Sciences 21, no. 19 (2020): 7177. http://dx.doi.org/10.3390/ijms21197177.

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Current chemotherapeutic drugs, although effective, lack cell-specific targeting, instigate adverse side effects in healthy tissue, exhibit unfavourable bio-circulation and can generate drug-resistant cancers. The synergistic use of nanotechnology and gene therapy, using nanoparticles (NPs) for therapeutic gene delivery to cancer cells is hereby proposed. This includes the benefit of cell-specific targeting and exploitation of receptors overexpressed in specific cancer types. The aim of this study was to formulate dendrimer-functionalized selenium nanoparticles (PAMAM-SeNPs) containing the tar

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Bodnar, O. I., H. B. Kovalska, O. Ya Lukashiv та V. V. Grubinko. "ОЦІНКА БІОЛОГІЧНОЇ ДІЇ ЕЛЕМЕНТВМІСНИХ ЛІПІДНИХ КОМПЛЕКСІВ З CHLORELLA VULGARIS НА ФУНКЦІОНАЛЬНИЙ СТАН ЗДОРОВИХ ЩУРІВ". Scientific Issue Ternopil Volodymyr Hnatiuk National Pedagogical University. Series: Biology 80, № 3-4 (2020): 50–62. http://dx.doi.org/10.25128/2078-2357.20.3-4.7.

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Chlorella is one of the most promising species of algae, which is widely cultivated for the industrial production of nutraceuticals in the form of tablets or powder. The value of Chlorella is primarily due to the high content of proteins and lipids (51–58 % and 20–23 % of dry weight respectively), carotenoids and an almost complete set of vitamins. At the same time, in the process of cultivation, a method was developed to enrich algobiomass and its individual components (primarily the lipid fraction) with selenium, zinc, chromium, as important regulatory trace elements. From chlorella, w

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Zhukova, I. O., Yu S. Svitlychna–Kulak та N. I. Longus. "КОРЕКЦІЯ СТАНУ АНТИОКСИДАНТНОГО ЗАХИСТУ У СОБАК ЗА ОТРУЄННЯ НЕОВЕРМОМ". Scientific Messenger of LNU of Veterinary Medicine and Biotechnology 18, № 3(70) (2016): 95–100. http://dx.doi.org/10.15421/nvlvet7022.

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The data on the impact of the drug «Neoverm» on the dogs have been presented in the article. The drug was administered into the stomach at the dose of 0.6 mg/kg of live weight for three days and the antioxidant drugs «E–Selenium» and «Quercetin» as well as green buckwheat and hepaprotector «L’esphal» as natural antioxidant preparations were used. «Neoverm» is a new antiparasitic drug that belongs to the group of medicines of broad–spectrum of action of the avermectin derivatives.The main active substance is ivermectin (10 mg), it belongsto the group of compounds which are the product of enzymi

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Walker, Kaden, Zachary Griffin, and Merrill Christensen. "Optimizing Mixtures of Se Compounds as Adjuvants to Therapeutic Agents." Current Developments in Nutrition 4, Supplement_2 (2020): 1848. http://dx.doi.org/10.1093/cdn/nzaa067_075.

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Abstract Objectives Different chemical forms of selenium (Se) regulate distinct sets of genes and have different metabolic effects. We previously showed that mixtures of different Se compounds can have greater inhibitory effects on prostate cancer cell viability than individual chemical forms. Further, we showed that blends of different Se forms can be optimized using response surface methodology. Previous investigators showed that single forms of Se can potentiate the effects of chemotherapeutic and other agents. We hypothesized that optimized mixtures of different forms of Se would be more e

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13

Ji, Jing, Juan Liu, Haijuan Liu, and Yueling Wang. "Effects of Fermented Mushroom ofCordyceps sinensis, Rich in Selenium, on Uterine Cervix Cancer." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/173180.

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The purpose of this study was to investigate the effect of fermented mushroom ofCordyceps sinensis(CS), rich in selenium (Se-CS), on uterine cervical cancer in mice. The methylcholanthrene- (MCA-) induced tumor model was used in this paper. After the mice were administered Se-CS, the animals showed 40% tumor incidence (P<0.05). Se-CS also enhanced the immune functions. Se-CS treatment showed significant (P<0.05–0.01) restoration in the level of glutathione content, lipid peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+/K+-ATPase activi

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14

Doro, Nathaniel C., Deepika Lal, Youcef Rustum, and Eunice S. Wang. "Selenium Enhances the Anti-Angiogenic Effects of Bevacuzimab (Anti-VEGF Antibody) in Human Acute Myeloid Leukemia Xenograft Models." Blood 110, no. 11 (2007): 4216. http://dx.doi.org/10.1182/blood.v110.11.4216.4216.

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Abstract Selenium, a known antioxidant used in chemoprevention, has recently been shown to improve the efficacy of chemotherapy agents and mediate anti-angiogenic effects in preclinical solid tumor models. Prior data has also shown that sodium selenite can induce apoptosis of human acute myeloid leukemia (AML) cells in vitro. While the use of high non-toxic doses of selenium has been demonstrated to effectively enhance the therapeutic efficacy and selectivity of various anti-cancer drugs in multiple solid tumor xenograft models (Cao et al, Clin Canc Res10: 2561–2569, 2004), the in vivo effects

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15

Singh, Dhireshan, and Moganavelli Singh. "Hepatocellular-Targeted mRNA Delivery Using Functionalized Selenium Nanoparticles In Vitro." Pharmaceutics 13, no. 3 (2021): 298. http://dx.doi.org/10.3390/pharmaceutics13030298.

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Selenium’s (Se) chemopreventative and therapeutic properties have attracted attention in nanomedicine. Se nanoparticles (SeNPs) retain these properties of Se while possessing lower toxicity and higher bioavailability, potentiating their use in gene delivery. This study aimed to formulate SeNPs for efficient binding and targeted delivery of FLuc-mRNA to hepatocellular carcinoma cells (HepG2) in vitro. The colorectal adenocarcinoma (Caco-2) and normal human embryonic kidney (HEK293) cells that do not have the asialoorosomucoid receptor (ASGPR) were utilized for comparison. SeNPs were functionali

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16

Mousa, Shaker A., Seema Mohamed, Laura O’Connor, and Eric Block. "Sulfur- and Selenium-Containing Compounds Derived from Natural and Synthetic Sources in Angiogenesis Modulation." Blood 104, no. 11 (2004): 3924. http://dx.doi.org/10.1182/blood.v104.11.3924.3924.

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Abstract Increases in serum sulfate may explain some of the therapeutic effects of methylsulfonyl methane (MSM), dimethyl sulfoxide, and glucosamine sulfate. Organic sulfur, as sulfur-containing amino acids, can be used to increase synthesis of S-adenosylmethionine, glutathione, taurine, and N-acetylcysteine. MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders. Epidemiological studies have suggested that brassica vegetables are protective against cancers of the lungs and alimentary tract. Cruciferous vegetables are the dietary source of g

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17

Falnoga, Ingrid, Darja Mazej, Helena Podgornik, Samo Zver, Peter Cernelc, and Zdenka Slejkovec. "Critical Serum-Selenium Levels in APL and MM Patients during ATO-Treatment (According to APL and MAC/DAC Schemes)." Blood 124, no. 21 (2014): 5231. http://dx.doi.org/10.1182/blood.v124.21.5231.5231.

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Abstract Introduction Arsenic trioxide (As2O3; ATO; Trisenox®) is an antineoplastic chemotherapeutic agent used for the treatment of acute promyelocytic leukemia (APL) and experimentally also for other malignancies including multiple myeloma (MM). As the therapeutic doses are rather high, and arsenic-selenium interactions well-known (arsenic complexation by selenium with subsequent excretion by bile), we assume that arsenic interferes in the selenium (Se) metabolism during the treatment. As selenium deficiency (<40 ng Se/g) can be detrimental in many ways, the aim of our study was to follow

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18

Benvenga, Salvatore, Ulla Feldt-Rasmussen, Daniela Bonofiglio, and Ernest Asamoah. "Nutraceutical Supplements in the Thyroid Setting: Health Benefits beyond Basic Nutrition." Nutrients 11, no. 9 (2019): 2214. http://dx.doi.org/10.3390/nu11092214.

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In recent years, there has been a growing interest in nutraceuticals, which may be considered as an efficient, preventive, and therapeutic tool in facing different pathological conditions, including thyroid diseases. Although iodine remains the major nutrient required for the functioning of the thyroid gland, other dietary components play important roles in clinical thyroidology—these include selenium, l-carnitine, myo-inositol, melatonin, and resveratrol—some of which have antioxidant properties. The main concern regarding the appropriate and effective use of nutraceuticals in prevention and

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19

Bednarczuk, Tomasz, and Lutz Schomburg. "Challenges and perspectives of selenium supplementation in Graves’ disease and orbitopathy." Hormones 19, no. 1 (2019): 31–39. http://dx.doi.org/10.1007/s42000-019-00133-5.

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Abstract Purpose This review focuses on the results of prospective randomized clinical trials and the conclusions from respective meta-analyses in order to summarize experiences with adjuvant selenium (Se) supplementation in Graves’ hyperthyroidism and orbitopathy, while identifying ambiguous findings and highlighting important open research issues. Methods We searched the PubMed and the Cochrane Central Register of Controlled Trials (CENTRAL) through May 31, 2019, for relevant studies. Results The available evidence concerning routine use of Se in the treatment of Graves’ hyperthyroidism rema

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Oeverhaus, Michael, Mareile Stöhr, Lars Möller, Dagmar Führer та Anja Eckstein. "Gravesʼ Orbitopathy: Current Concepts for Medical Treatment". Klinische Monatsblätter für Augenheilkunde 238, № 01 (2021): 24–32. http://dx.doi.org/10.1055/a-1328-2884.

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Abstract Background The therapy of severe manifestations of Gravesʼ orbitopathy (GO) is still a challenge and requires good interdisciplinary cooperation. It is especially important to use stage-adapted anti-inflammatory therapy to avoid irreversible damage. Material and Methods Discussion of the latest results of multicentre randomised therapy studies on anti-inflammatory treatments for Gravesʼ orbitopathy, as well as new therapeutic concepts. Results Mild cases of GO can be treated with only selenium supplementation and a watchful waiting strategy. In the moderate-to-severe active form of GO

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Ida Christi V E, Krishnaprabha C, Blesson Sha Fogarty N I, Sangilimuthu A, and Kumutha D. "Estimation of Heavy Metals in Selected Medicinal Herbs." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 4619–24. http://dx.doi.org/10.26452/ijrps.v11i3.2745.

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Worldwide nearly 80% of peoples are using the medicinal plants for basic illness due to the presence of primary metabolites, secondary metabolites, minerals and inorganic salts. Some Inorganic minerals available in plants are useful for health and have therapeutic value and some heavy metals are dangerous for health and may cause damage to internal organs. In view of that, the present study designed to quantitatively evaluate the presence of inorganic minerals like Sodium, Potassium, Calcium, Magnesium, Zinc and Copper and heavy metal like Mercury, Arsenic, Lead, Cadmium, Selenium, Cobalt and

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Schuerger, Nikolas, Evelyn Klein, Alexander Hapfelmeier, Marion Kiechle, Christine Brambs, and Daniela Paepke. "Evaluating the Demand for Integrative Medicine Practices in Breast and Gynecological Cancer Patients." Breast Care 14, no. 1 (2018): 35–40. http://dx.doi.org/10.1159/000492235.

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Introduction: Integrative medicine is becoming increasingly relevant to modern oncology. The present study aims to assess the demand for integrative therapeutic approaches including complementary and alternative medicine (CAM), body and mind practices, nutritional counseling, and psychological assistance among breast and gynecological cancer patients. Methods: From April to July 2017, a pseudo-anonymous questionnaire was distributed to cancer patients at the Department of Gynecology and Obstetrics, Technical University of Munich. Patterns of CAM use and demand for integrative health approaches

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Valdés-Ramos, Roxana, and Alejandra D. Benítez-Arciniega. "Nutrition and immunity in cancer." British Journal of Nutrition 98, S1 (2007): S127—S132. http://dx.doi.org/10.1017/s0007114507833009.

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The purpose of this article is to give a general overview of the effects of nutrition on the development of cancer as well as part of a therapeutic approach. There is much evidence that diet and lifestyle can alter the risk of cancer development as is the case for many other chronic diseases. This may be through a direct action on the immune system, either by enhancing or suppressing it, as well as on the development of the tumour itself, by modulating gene expression or by antioxidant activity. Protective effects can be achieved by adequate intakes of vitamins A and C, β-carotene, selenium an

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Bulucu, F., C. Oktenli, L. Kenar, et al. "Detrimental Effects of N-Acetylcysteine Plus Desferoxamine Combination in an Experimental Nephrotic Syndrome Model." International Journal of Toxicology 26, no. 6 (2007): 525–32. http://dx.doi.org/10.1080/10915810701707403.

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The aim of this study was to evaluate the effects of N-acetylcysteine (NAC) and desferoxamine (DFO) administered alone or in combination together in rats with doxorubicin (DOX)-induced nephrotic syndrome, by monitoring oxidative stress parameters and trace elements in renal tissue and erythrocytes. Fifty-four male Sprague-Dawley rats were included the study. Equal volume of isotonic saline was injected to control rats. After DOX administration, the animals were divided into four experimental groups: (a) rats given only DOX; (b) rats treated with NAC; (c) rats treated with DFO; (d) rats treated

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Bityutsky, V. S., S. I. Tsekhmistrenko, О. S. Tsekhmistrenko, N. O. Tymoshok, and M. Y. Spivak. "Regulation of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators." Regulatory Mechanisms in Biosystems 11, no. 4 (2020): 483–93. http://dx.doi.org/10.15421/022074.

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The article is devoted to the mechanisms of regulation of redox processes in cells, a review of the Keap1 / Nrf2 / ARE redox-sensitive signaling system as a fundamental pathway that plays a key role in maintaining cellular redox homeostasis under stressful, inflammatory, carcinogenic and proapoptotic conditions. The structure of the cysteine-rich repressor protein Keap1, which is responsible for sensory perception of electrophiles and reactive oxygen species, the structure and functions of the transcription factor Nrf2, mechanisms of Nrf2 activation through the Keap1 / Nrf2 / ARE signaling sys

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Betz, Yu A., N. L. Naumova, and I. N. Minashina. "Functional components of non-traditional raw materials in the design of bakery products." Innovations and Food Safety, no. 1 (April 15, 2021): 7–13. http://dx.doi.org/10.31677/2072-6724-2021-31-1-7-1.

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Wheat bread remains in the diet not only of Russians, but also of the population of other countries as a daily product, which makes it possible to consider it as an object for modifying the chemical composition and nutritional value in order to give it functional, dietary, or therapeutic and prophylactic properties. The purpose of the research is to study the composition of the functional components of non-traditional types of flour used in wheat bread technology in order to establish the effectiveness of their use. The objects of research were: bakery wheat flour of the highest grade, walnut

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Dong, RuiHua. "Blood Lead, Nutrient Intake, and Renal Function Among Type 2 Diabetic Patients." Current Developments in Nutrition 4, Supplement_2 (2020): 1395. http://dx.doi.org/10.1093/cdn/nzaa061_023.

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Abstract Objectives We hereby reported cross-sectional findings on impaired renal function in association with the exposure to lead (Pb) and dietary intake of nutrients among patients with type 2 diabetes (T2D). Methods Pb exposure and renal injury was assessed by the measurement of blood lead levels (BLLs) and biochemical parameters, respectively, in 780 patients. The intake of dietary nutrients was assessed by food frequency questionnaire in 420 of 780 participants. Results The BLLs were found to be significantly associated with certain parameters of renal injury in both ordinary least squar

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Karakka Kal, Abdul Khader, Zubair Perwad, Tajudheen K Karatt, Jahfar Nalakath, and Michael Subhahar. "Using Inductively Coupled Plasma Mass Spectrometry to Assess Essential and Performance-Enhancing Metals in the Urine of Racehorses." Journal of Analytical Toxicology 44, no. 5 (2020): 490–98. http://dx.doi.org/10.1093/jat/bkaa004.

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Abstract Recently, an increased tendency to use various metals has been observed in the sports competition fields. Many of these metals and their organic complexes reportedly have good pharmacologic, therapeutic and performance-enhancement uses; they are banned or recommended as controlled medications in competitive sports. The objective of this research was to determine the concentration of pharmacologically relevant metals in urine samples collected from racehorses at various sport events, develop a method and assess the concentrations of above metals using inductively coupled plasma mass sp

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Szymański, Marek, Tomasz Wandtke, Karolina Wasilow, Marek Andryszczyk, Radosław Janicki, and Piotr Domaracki. "Comparison of 3- and 6-Month Outcomes of Combined Oral L-Carnitine Fumarate and Acetyl-L-Carnitine Therapy, Included in an Antioxidant Formulation, in Patients with Idiopathic Infertility." American Journal of Men's Health 15, no. 5 (2021): 155798832110367. http://dx.doi.org/10.1177/15579883211036790.

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The male factor is responsible for infertility in about 35–40% of all cases. Idiopathic oligo- and/or astheno- and/or therato-zoospermia is one of the most common male fertility disorders and remains a significant therapeutic challenge. The primary cause of idiopathic male infertility remains unknown but seems to be associated with oxidative stress. Objective: The use of antioxidative formulation to improve qualitative and quantitative deficiencies in the male gametes. In total, 78 subjects were treated with a combination of 1,725 mg L-carnitine fumarate, 500 mg acetyl-L-carnitine, 90 mg vitam

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Holt, Jason A., Edward P. Garvey, J. David Becherer, William J. Hoekstra, Robert J. Schotzinger, and Christopher M. Yates. "SE-7552, a Highly Selective, Non-Hydroxamate Inhibitor of Histone Deacetylase-6 Blocks Multiple Myeloma Growth In Vivo." Blood 132, Supplement 1 (2018): 3215. http://dx.doi.org/10.1182/blood-2018-99-113066.

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Abstract Despite recent advances, disease progression and treatment resistance in multiple myeloma (MM) remains a significant challenge. Current therapies include proteasome inhibitors, immunomodulatory agents, monoclonal antibodies and more recently histone deacetylase (HDAC) inhibitors. Many HDAC inhibitors have progressed into clinical development, however, there has been limited success with the approval of only three pan-HDAC inhibitors (SAHA, belinostat and panobinostat) and the class I selective inhibitor, romidepsin. A challenge to the development of HDAC inhibitors has been the manage

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Maiyo, Fiona C., Londiwe S. Mbatha, and Moganavelli Singh. "Selenium Nanoparticles in Folate-Targeted delivery of the pCMV-Luc DNA Reporter Gene." Current Nanoscience 16 (December 7, 2020). http://dx.doi.org/10.2174/1573413716666201207141657.

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Background: Selenium, an essential micronutrient, has been studied for decades for its anticancer properties. Selenium nanoparticles (SeNPs) have now emerged as an interesting alternative for drug and gene delivery. Aims: We aimed to demonstrate in proof of principle, the potential use of SeNPs in targeted pCMV-Luc DNA (pDNA) delivery in vitro. Objectives: To chemically synthesize, characterize and evaluate the transgene expression of functionalized SeNPs in five human cell lines. Methods: SeNPs were synthesized via chemical reduction, coated with chitosan (Ch) and a targeting moiety folic aci

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"Therapeutic and Diagnostic Applications of Nanocomposites in the Treatment Alzheimer’s Disease Studies." Biointerface Research in Applied Chemistry 12, no. 1 (2021): 940–60. http://dx.doi.org/10.33263/briac121.940960.

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Alzheimer’s disease, a neurodegenerative disorder, refers to a particular onset and course of cognitive and functional decline associated with alteration in particular neuropathology. To combat this, Nanotechnology is an emerging field that uses nanoparticles acting at the molecular level and has a major impact on a wide variety of biomedical and pharmaceutical applications, particularly in treating Alzheimer’s disease. This technology is functionalized to effect at the Nanoscale dimension via the use of nanocomposites and chimeric peptides having the ability to penetrate the blood-brain barri

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Abusabeib, Alyaa, Walid El Ansari, Jassim Alobaidan, and Wahiba Elhag. "First Case Report of Fulminant Hepatitis After Laparoscopic Sleeve Gastrectomy Associated with Concomitant Maximal Therapeutic Dose of Acetaminophen Use, Protein Calorie Malnutrition, and Vitamins A and D, Selenium, and Glutathione Deficiencies." Obesity Surgery, October 22, 2020. http://dx.doi.org/10.1007/s11695-020-04999-y.

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Abstract Nonalcoholic fatty liver disease (NAFLD) is increasingly being linked to obesity. Although laparoscopic sleeve gastrectomy (LSG) is effective for weight loss that can ultimately resolve NAFLD, an initial transient deterioration of liver functions could be observed during the first few months post-operatively, after which a subsequent improvement of the liver functions might occur. Rapid weight loss, nutritional deficiencies, and protein malnutrition can all contribute to hepatic dysfunction and can affect the metabolism of medications such as acetaminophen leading to more insult to a

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An, Yulin, and Jianfu Zhao. "Functionalized Selenium Nanotherapeutics Synergizes With Zoledronic Acid to Suppress Prostate Cancer Cell Growth Through Induction of Mitochondria-Mediated Apoptosis and Cell Cycle S Phase Arrest." Frontiers in Oncology 11 (June 8, 2021). http://dx.doi.org/10.3389/fonc.2021.685784.

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The use of established drugs in new therapeutic applications has great potential for the treatment of cancers. Nanomedicine has the advantages of efficient cellular uptake and specific cell targeting. In this study, we investigate using lentinan-functionalized selenium nanoparticles (LET-SeNPs) for the treatment of prostate cancer (PCa). We used assays to demonstrate that a combination of LET-SeNPs and zoledronic acid (ZOL) can reduce PCa cell viability in vitro. Stability and hemocompatibility assays were used to determine the safety of the combination of LET-SeNPs and ZOL. The localization o

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Poonia, Amrita, and Surabhi Pandey. "Bioactive compounds, nutritional benefits and food applications of black rice: a review." Nutrition & Food Science ahead-of-print, ahead-of-print (2021). http://dx.doi.org/10.1108/nfs-07-2021-0208.

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Purpose The purpose of this paper is to review the nutritional composition, phytochemicals and bioactive compounds of black rice such as flavonoids, phenolic compounds and their health benefits. Black rice has also been used in medicine and for curing diabetes, obesity, cardiovascular diseases and cancer. Green technologies such as microwave-assisted extraction, supercritical fluid extraction and pulse electric field assisted extraction are very useful for the extraction of bioactive compounds as these reduce the use of energy and are environmental friendly. Black rice in different forms can b

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