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Journal articles on the topic 'Self-emulsifying capsule'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Patel, Vipul P., Hardik A. Lakkad, and Kalpesh Chhotalal Ashara. "Formulation Studies of Solid Self-Emulsifying Drug Delivery System of Ivermectin." Folia Medica 60, no. 4 (2018): 580–93. http://dx.doi.org/10.2478/folmed-2018-0024.

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Abstract Background: The suggested dose of ivermectin is 300 μG/kg/day for onchocerciasis but it has low water solubility and poor oral bioavailability. Aim: To prepare and evaluate a solid lipid-based self-emulsifying drug delivery system of ivermectin. Materials and methods: Based on supersaturated solubility study, oil, surfactant, and co-surfactant were selected. On the basis of ternary phase diagrams and simplex-lattice design, self-emulsifying, drug delivery formulations had been developed and optimized. Ivermectin-excipients compatibility studies were performed using differential scanni

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Harsh, Pathak, Pande Sonal, Jiwani Munaf, Ankalge Rajesh, and Rohit Mehul. "Pharmaceutical Aspects of Self Emulsifying Drug Delivery System: A Comprehensive Review." Recent Trends in Pharmaceutical Sciences and Research 2, no. 1 (2019): 19–44. https://doi.org/10.5281/zenodo.3474625.

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<em>Low aqueous solubility of the newly discovered drug possesses a great challenge for the development of dosage form with suitable applicability. Self-Emulsifying Drug Delivery System (SEDDS) provides an excellent alternative for increasing solubility of lipid soluble drugs which is achieved by microemulsion through chemical means. </em><em>Self-Emulsifying drug delivery system is the blend of surfactants and oils which are isotropic in nature. It also includes co-solvents which upon gentle agitation gets emulsified under conditions mimicking to those which would be encountered in the gastro

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Park, Heejun, Eun-Sol Ha, and Min-Soo Kim. "Current Status of Supersaturable Self-Emulsifying Drug Delivery Systems." Pharmaceutics 12, no. 4 (2020): 365. http://dx.doi.org/10.3390/pharmaceutics12040365.

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Self-emulsifying drug delivery systems (SEDDSs) are a vital strategy to enhance the bioavailability (BA) of formulations of poorly water-soluble compounds. However, these formulations have certain limitations, including in vivo drug precipitation, poor in vitro in vivo correlation due to a lack of predictive in vitro tests, issues in handling of liquid formulation, and physico-chemical instability of drug and/or vehicle components. To overcome these limitations, which restrict the potential usage of such systems, the supersaturable SEDDSs (su-SEDDSs) have gained attention based on the fact tha

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4

S.G.Gavande, R.O.Sonwane A.D.Pichkewar S.S.Dorik. "REVIEW ON IMMEDIATE RELEASE DOSAGE FORM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 04 (2019): 8509–18. https://doi.org/10.5281/zenodo.2652693.

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<em>Most popular immediate release dosage forms such as tablet, capsule and pellet.</em><em> Because of its convenience of self-administration, and simple to the manufacturing. The type of dosage from is some advantages such as improved stability of formulation. Improved bioavablity of Product. Rapid onset action and cost effective as compare to other dosage formulation. They disintegrant are selected as type of dosage and physical characteristics of drugs. </em><em>The basic approach used in development tablets, capsule and pellet as the use of some excipient like superdisintegrants, Bulking

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5

Ansari, Khalid Akhter, Kunal Pratap Pagar, Shoeb Anwar, and Pradeep Ratilal Vavia. "Design and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application." Brazilian Journal of Pharmaceutical Sciences 50, no. 1 (2014): 203–12. http://dx.doi.org/10.1590/s1984-82502011000100021.

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The objective of this research work was to design, develop and optimize the self micro-emulsifying drug delivery system (SMEDDS) of Felodipine (FL) filled in hard gelatine capsule coated with polymer in order to achieve rapid drug release after a desired time lag in the management of hypertension. Microemulsion is composed of a FL, Lauroglycol FCC, Transcutol P and Cremophor EL. The optimum surfactant to co-surfactant ratio was found to be 2:1. The resultant microemulsions have a particle size in the range of 65-85 nm and zeta potential value of -13.71 mV. FL release was adequately adjusted by

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Wannas, Ali N., and Nidhal K. Maraie. "Preparation and in-vitro evaluation of cilostazol self-emulsifying drug delivery system." Al Mustansiriyah Journal of Pharmaceutical Sciences 20, no. 1 (2020): 13–30. http://dx.doi.org/10.32947/ajps.v20i1.682.

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This work reported a first liquid self-nanoemulsifying drug delivery system (SEDD) of cilostazol using oleic acid as oil phase, tween 80 as surfactant, and transcutol as co-surfactant. Cilostazol is a poor water-soluble phosphodiesterase III inhibitor, which has antiplatelet  and vasodilator effect used to relief intermittent claudication symptoms. Cilostazol solubility was determined in various oils, surfactants and co-surfactants and phase diagram was constructed at different oil: surfactant: co-surfactant ratios to determine the existence of nano-emulsion region. The in-vitro di

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Shi, Fang, Jingchun Wu, and Bo Zhao. "Preparation and Investigation of Intelligent Polymeric Nanocapsule for Enhanced Oil Recovery." Materials 12, no. 7 (2019): 1093. http://dx.doi.org/10.3390/ma12071093.

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Micro-/nanomotors colloidal particles have attracted increasing interest as composite surfactants, owing to the combined advantages of both Janus solid surfactants and micro-/nanomotors. Here we put micro-/nanomotors colloidal particles into hollow polymeric micro-encapsulates. An intelligent polymeric nanocapsule was prepared for enhanced oil recovery by the self-assembly method. The particle size range of the polymeric capsule can be controlled between 20 to 1000 nm by adjusting the cross-linking thickness of the capsule’s outer membrane. The average particle size of polymeric capsules prepa

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Sin, Gi Hyeong, Sun Ho Hong, Yoon Tae Goo, Hyun Min Jung, Sangkil Lee, and Young Wook Choi. "Soft-capsule formulation of a re-esterified triglyceride omega-3 employing self-emulsifying technology and bioavailability evaluation in healthy volunteers." Heliyon 9, no. 10 (2023): e20376. http://dx.doi.org/10.1016/j.heliyon.2023.e20376.

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9

Hasan, Naser M. y., Dhaifallah M. Almalki, Mohammed J. k. Althuwaybi, and Hassan M. Alshehri. "SMEDDS TABLET: COMPATABILITY OF SOLID SMEDDS USING VARIOUS PHARMACEUTICAL TABLET EXCIPIENTS." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 9 (2016): 246. http://dx.doi.org/10.22159/ijpps.2016v8i9.13409.

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<p><strong>Objective: </strong>There are many successful products on the market which are the culmination of the self-micro-emulsification lipid technology applications. Despite the importance of lipid-based formulations, these systems have some limitations including; stability, complexity during large scale manufacturing process and limited dosage forms to such as soft gelatin capsule. In order to overcome these limitations, the prospect of converting self-micro-emulsifying drug delivery systems (SMEDDS) into tablet dosage form was investigated in this study.</p><p&

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10

Akhter, Sadika, and Md Ismail Hossain. "Dissolution enhancement of Capmul PG8 and Cremophor EL based Ibuprofen Self Emulsifying Drug Delivery System (SEDDS) using Response surface methodology." International Current Pharmaceutical Journal 1, no. 6 (2012): 138–50. http://dx.doi.org/10.3329/icpj.v1i6.10535.

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In this study, a solubility enhancing technique, Self-emulsifying drug delivery system (SEDDS), was considered to be developed for Ibuprofen, a poorly soluble drug. Capmul PG 8 was used as a co-solvent. As surfactant, hydrophilic surfactant Cremophor EL was considered. A fixed amount of Ibuprofen was added with fixed amount of excipients. Capmul PG8 showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. Cremophor EL also showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. Ibuprofen is a poorly soluble drug which was used as experimental drug and pH

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11

Блынская, E. Blynskaya, Турчинская, et al. "The Technology of Self-Emulsifying Drug Delivery Systems." Journal of New Medical Technologies 21, no. 1 (2014): 128–33. http://dx.doi.org/10.12737/3320.

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Nearly 40% of novel chemical entities show evidence of low solubility in water and low bioavailability. Self-emulsifying formulations have showed the power to improve the bioavailability of hydrophobic drugs. Self-emulsifying formulations belong to lipid formulations, and their size range from 100 nm in case of self-emulsifying drug delivery systems and less than 50 nm in case of self-microemulsifying drug delivery systems. In general self-emulsifying formulations s represent isotropic mixtures of oils, surfactants and co-surfactants, which emulsify spontaneous in aqueous media under condition

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Deepshikha, Kukde, and Bharkatiya Meenakshi. "Self-emulsifying Drug Delivery System: An Overview with Novel Perspective." Pharmaceutical and Chemical Journal 9, no. 2 (2022): 77–89. https://doi.org/10.5281/zenodo.13970481.

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Self-emulsifying drug delivery systems, which are isotropic mixtures of oils, surfactants, solvents, and co-solvents or surfactants, may be used to design formulations to boost oral absorption of highly lipophilic drug compounds. It may be orally administered in soft or hard gelatin capsules. These systems form fine emulsions or micro-emulsions in the gastro-intestinal tract with mild agitation provided by gastric mobility. These formulations were increased bioavailability due to increasing the solubility of the drug and minimize gastric irritation. The very fact is that almost 40% of the new

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13

N., Likitha, and Sandeep K. "Self Emulsifying Drug Delivery System." International Journal of Innovative Science and Research Technology 7, no. 11 (2022): 33–40. https://doi.org/10.5281/zenodo.7319153.

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Self-emulsifying drug delivery systems (SEEDS) are mixtures of perfect isotropic oils and surfactants, with or without cosolvents, that emulsify when gently agitated, similar to the conditions found in the gastrointestinal tract. These systems cause the gastro-intestinal tract (GIT) to mildly agitate while forming fine emulsions (or micro-emulsions). The oral absorption of drugs from SEEDS is greatly influenced by a number of factors, including surfactant concentration, oil/surfactant ratio, polarity of the emulsion, droplet size, and charge. This formulation improves bioavailability by increa

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14

Bodnar, Liubov, Nataliia Polovko, Nataliia Bevz, Volodymyr Hrudko, and Olesia Perepelytsia. "Biopharmaceutical justification of the creation of self-emulsifying drug delivery systems with simvastatin." ScienceRise: Pharmaceutical Science, no. 2(42) (April 30, 2023): 4–10. http://dx.doi.org/10.15587/2519-4852.2023.277351.

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The aim of the research – to conduct biopharmaceutical tests of capsules with a self-emulsifying delivery system of simvastatin to confirm the effectiveness and feasibility of introducing into the composition of self-emulsifying drug delivery systems active pharmaceutical ingredients that are difficult to dissolve in the gastric juice environment. Material and methods. Substances, excipients, reagents and materials used during research were simvastatin (India, p. DK40-2005021, 99.09 %), castor oil (Ukraine), polyethylene glycol 40 hydrogenated castor oil (India), Tween 80 (Ukraine), glyc

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Liubov, Bodnar, Polovko Nataliia, Bevz Nataliia, Hrudko Volodymyr, and Perepelytsia Olesia. "Biopharmaceutical justification of the creation of self-emulsifying drug delivery systems with simvastatin." ScienceRise: Pharmaceutical Science, no. 2(42) (April 30, 2023): 4–10. https://doi.org/10.15587/2519-4852.2023.277351.

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<strong>The aim of the research </strong>– to conduct biopharmaceutical tests of capsules with a self-emulsifying delivery system of simvastatin to confirm the effectiveness and feasibility of introducing into the composition of self-emulsifying drug delivery systems active pharmaceutical ingredients that are difficult to dissolve in the gastric juice environment. <strong>Material and methods. </strong>Substances, excipients, reagents and materials used during research were simvastatin (India, p. DK40-2005021, 99.09 %), castor oil (Ukraine), polyethylene glycol 40 hydrogenated

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16

Gupta, Shweta, Rajesh Kesarla, and Abdelwahab Omri. "Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems." ISRN Pharmaceutics 2013 (December 26, 2013): 1–16. http://dx.doi.org/10.1155/2013/848043.

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Poorly water-soluble drug candidates are becoming more prevalent. It has been estimated that approximately 60–70% of the drug molecules are insufficiently soluble in aqueous media and/or have very low permeability to allow for their adequate and reproducible absorption from the gastrointestinal tract (GIT) following oral administration. Formulation scientists have to adopt various strategies to enhance their absorption. Lipidic formulations are found to be a promising approach to combat the challenges. In this review article, potential advantages and drawbacks of various conventional technique

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M, Mounika, Kumar Desu Prasanna, and Vanitha K. "A Review on Self Nano Emulsifying Drug Delivery System." Trends in Pharmaceuticals and Nanotechnology (e-ISSN: 2582-4457) 2, no. 1 (2019): 12–23. https://doi.org/10.5281/zenodo.3579794.

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<em>A self-nano emulsifying drug delivery system (SNEDDS) is a scheme of drug delivery that utilizes a chemical rather than a mechanical method of Nano emulsion . That is, by an intrinsic property of the drug formulation. It utilizes the familiar ouzo impact shown by anethole in many anise-flavored liquors, rather than by unique blending and handling Nano emulsion s have significant potential for use in the delivery of drugs, and SNEDDS (including so-called "U-type" nano emulsions) is the best of those systems to date identified. SNEDDS are of particular value in increasing the absor

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18

Alves, Suzana Ferreira, Ricardo Neves Marreto, and Maria Teresa Freitas Bara. "Enhanced geranylgeraniol stability and dissolution from self-emulsifying pellets containing the sucupira (Pterodon emarginatus Vogel) standardized extract." Research, Society and Development 12, no. 4 (2023): e26012441314. http://dx.doi.org/10.33448/rsd-v12i4.41314.

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The vegetal species sucupira (Pterodon emarginatus Vogel) presents some diterpenes that have anti-inflammatory activities. However, diterpenes are poorly water-soluble compounds. The development of Self-Emulsifying Drug Delivery Systems (SEDDS) allows for obtaining a solid dosage form that maximizes the release of P. emarginatus constituents in an aqueous medium. This work aimed to obtain and characterize pellets containing the SEDDS prepared from P. emarginatus extract using the extrusion-spheronization technique. Formulations PF1 to PF6 were tested. Then, self-emulsifying formulations were p

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Dash, Tapaswi Rani* Sharma Pankaj Sharma Sawati Sood Parul. "NOVEL SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) FOR ORAL DELIVERY OF LIPOPHILIC DRUGS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7361–68. https://doi.org/10.5281/zenodo.1006753.

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The self-nanoemulsifying drug delivery system (SNEDDS), is a promising Drug Delivery System which is well known for its prospective to improve the aqueous solubility and oral absorption of poorly water soluble drugs (Pouton, 2000). SNEDDS is an isotropic mixture comprising oil, surfactant, co-surfactant and drug that form oil in water emulsion in aqueous environment under placid agitation. It can readily disperse in the aqueous environment of the gastrointestinal tract to form a fine oil-in-water emulsion with a droplet size not exceeding 100 nm under mild agitation for improving the oral bioa

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Halbaut, L., C. Barbé, and A. del Pozo. "An investigation into physical and chemical properties of semi-solid self-emulsifying systems for hard gelatin capsules." International Journal of Pharmaceutics 130, no. 2 (1996): 203–12. http://dx.doi.org/10.1016/0378-5173(95)04296-2.

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Nazlı, Hakan, Burcu Mesut, Özlem Akbal-Dağıstan, and Yıldız Özsoy. "A Novel Semi-Solid Self-Emulsifying Formulation of Aprepitant for Oral Delivery: An In Vitro Evaluation." Pharmaceutics 15, no. 5 (2023): 1509. http://dx.doi.org/10.3390/pharmaceutics15051509.

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Aprepitant is the first member of a relatively new antiemetic drug class called NK1 receptor antagonists. It is commonly prescribed to prevent chemotherapy-induced nausea and vomiting. Although it is included in many treatment guidelines, its poor solubility causes bioavailability issues. A particle size reduction technique was used in the commercial formulation to overcome low bioavailability. Production with this method consists of many successive steps that cause the cost of the drug to increase. This study aims to develop an alternative, cost-effective formulation to the existing nanocryst

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Nagaveni, Pommala Pranuth Atthoti Swetha Meeniga Mounika Gandham Saravanakumar kasimedu. "A Review on Physico-Chemical and Biopharmaceutical Aspects of Self-Micro Emulsifying Drug Delivery System (SMEDDS)." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 994–1005. https://doi.org/10.5281/zenodo.14638364.

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Nearly 40% of novel drug candidates demonstrate limited solubility in water, which is a difficulty in development of optimum oral solid dosage form in terms of formulation design and bioavailability of new pharmaceutical products. Many ways have been attempted to overcome these challenges either by means of changing the solubility or preserving the medicine in dissolved form beyond stomach transit time. These issues by altering the drug's solubility or keeping it liquid throughout the duration of the gastrointestinal transit. Lipid solutions, emulsions, and emulsion pre-concentrates have recei

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Sinka, Dávid, Enikő Doma, Nóra Szendi, et al. "Formulation, Characterization and Permeability Studies of Fenugreek (Trigonella foenum-graecum) Containing Self-Emulsifying Drug Delivery System (SEDDS)." Molecules 27, no. 9 (2022): 2846. http://dx.doi.org/10.3390/molecules27092846.

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Fenugreek is used as a spice and a traditional herbal medicine for a variety of purposes, given its antidiabetic and antioxidant effects. Self-emulsifying drug delivery systems (SEDDS) of herbal drugs are targets of extensive research aiming to increase bioavailability and stability. The study’s objective was to formulate SEDDS containing Trigonella foenum-graecum extract to improve the stability of herbal extract and to increase their permeability through a Caco-2 monolayer. A characterized fenugreek dry extract was used for the formulations, while the SEDDS properties were examined by partic

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Ameta, Rakesh Kumar, Kunjal Soni, and Ajaya Bhattarai. "Recent Advances in Improving the Bioavailability of Hydrophobic/Lipophilic Drugs and Their Delivery via Self-Emulsifying Formulations." Colloids and Interfaces 7, no. 1 (2023): 16. http://dx.doi.org/10.3390/colloids7010016.

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Formulations based on emulsions for enhancing hydrophobic and lipophilic drug delivery and its bioavailability have attracted a lot of interest. As potential therapeutic agents, they are integrated with inert oils, emulsions, surfactant solubility, liposomes, etc.; drug delivering systems that use emulsion formations have emerged as a unique and commercially achievable accession to override the issue of less oral bioavailability in connection with hydrophobic and lipophilic drugs. As an ideal isotropic oil mixture of surfactants and co-solvents, it self-emulsifies and forms fine oil in water e

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Niederquell, Andreas, Andreas Charles Völker, and Martin Kuentz. "Introduction of diffusing wave spectroscopy to study self-emulsifying drug delivery systems with respect to liquid filling of capsules." International Journal of Pharmaceutics 426, no. 1-2 (2012): 144–52. http://dx.doi.org/10.1016/j.ijpharm.2012.01.042.

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Vishakha, Vishwanath Doke, M. Khutle Nilesh, Sharma Maya, and Gupta Khemchand. "Solubility Enhancement of Poorly Soluble Drug Ezetimibe by Developing Self Nano Emulsifying Drug Delivery System." Indian Journal of Science and Technology 15, no. 30 (2022): 1504–16. https://doi.org/10.17485/IJST/v15i30.582.

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Abstract <strong>Objectives:</strong> To enhance solubility, dissolution, and permeability of poorly water-soluble drug Ezetimibe (EZE) using a self-nano emulsifying drug delivery system (SNEDDS). <strong>Methods:</strong> Initially, the solubility of the EZE was determined in various oils and buffers. Surfactants and co-surfactants were screened based on the solubility of the drug in oil as per the emulsification efficacy test. Liquid SNEDDS was developed and characterized. Solid SNEDDS was developed and characterized using optimized liquid SNEDDS followed by the development of

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V. More, Apoorva, Bharat V. Dhokchawle, Savita J. Tauro, and Savita V. Kulkarni. "LIPID AS AN EXCIPIENT FOR DESIGN AND DEVELOPMENT OF FORMULATIONS." Indian Drugs 59, no. 07 (2022): 7–20. http://dx.doi.org/10.53879/id.59.07.12199.

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Lipids are present abundantly in human body in several forms. Different types of lipids are available with diverse physical properties, based on which suitable lipids can be selected for development of formulations. Lipids are also available for specific purposes like lubrication, emulsification, emollientes and enhancement of bioavailability. Conventionally, many lipids are used in formulation of tablets, capsules, emulsions and cosmetics. In recent years, use of lipids for drug delivery has been extended to Solid Lipid Nanoparticles (SLN), Nanostructured Lipid Carriers (NLC), and Self-Micro

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Radha, G. V., K. Trideva Sastri, Sadhana Burada, and Jampala Rajkumar. "A SYSTEMATIC REVIEW ON SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEMS: A POTENTIAL STRATEGY FOR DRUGS WITH POOR ORAL BIOAVAILABILITY." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 23. http://dx.doi.org/10.22159/ijap.2019v11i1.29978.

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Currently a marked interest in developing lipid-based formulations to deliver lipophilic compounds. Self-emulsifying system has emerged as a dynamic strategy for delivering poorly water-soluble compounds. These systems can embrace a wide variety of oils, surfactants, and co-solvents. An immediate fine emulsion is obtained on exposure to water/gastro-intestinal fluids. The principal interest is to develop a robust formula for biopharmaceutical challenging drug molecules. Starting with a brief classification system, this review signifies diverse mechanisms concerning lipid-based excipients besid

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Ritschel, Wolfgang A. "Microemulsion technology in the reformulation of cyclosporine: the reason behind the pharmacokinetic properties of Neoral." Clinical Transplantation 10, no. 4 (1996): 364–73. http://dx.doi.org/10.1111/j.1399-0012.1996.tb00458.x.

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Management of transplant patients receiving cyclosporine therapy is complicated by interpatient and intrapatient variability in pharmacokinetic parameters caused by the drug's unpredictable bioavailability. Cyclosporine, a highly lipophilic cyclic polypeptide, has recently been reformulated using a microemulsion delivery system to improve its bioavailability. This new orally administered formulation, Neoral® (cyclosporine capsules and oral solution for microemulsion), has self‐emulsifying properties and spontaneously forms a microemulsion (particle size <0.15 μm) in the aqueous fluids of th

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Umadevi, Sankararajan, Rajathi Senthil Boopathi, and Ezhilarasan. "A paradigm shift in bioavailability enhancement using solid self emulisifying drug delivery system." Journal of Applied Pharmaceutical Research 13, no. 1 (2025): 14–24. https://doi.org/10.69857/joapr.v13i1.704.

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Background: Solids are physically and chemically more stable compared to liquid formulations. The Solid SEDDS form is preferred over the liquid SEDDS form to enhance the oral bioavailability of lipophilic medications. Solid SEDDS are isotropic mixtures of oil, surfactant, and co-solvent. Methodology: A liquid-solid compact approach is followed to convert liquid SEDDS into solid SEDDS. Melt granulation, melt extrusion, spray drying, adsorption to solid carriers, and freeze drying are some approaches to converting liquid SEDDS into solid SEDDS. Various solid self-emulsifying materials in several

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Zaghloul, Abdelazim, Ahmed Lila, Fathy Abd-Allah, and Aly Nada. "Probucol Self-Emulsified Drug Delivery System: Stability Testing and Bioavailability Assessment in Human Volunteers." Current Drug Delivery 16, no. 4 (2019): 325–30. http://dx.doi.org/10.2174/1567201816666181227111912.

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Background: Self-Emulsifying Drug Delivery System (SEDDS), if taken orally, is expected to self-emulsify in GIT and improve the absorption and bioavailability. Probucol (PB) is a highly lipophilic compound with very low and variable bioavailability. Objective: The objectives of this study were to examine the stability and conduct bioavailability of the prepared Probucol Self-Emulsified Drug Delivery System (PBSEDDS) in human volunteers. Methods: The methods included preparation of different PBSEDDS using soybean oil (solvent), Labrafil M1944CS (surfactant) and Capmul MCM-C8 (co-surfactant). Th

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Sanka, Krishna, Praneeth Kumar Muthyala, Praveen Kumar Gogu, Ramesh Jadhav, Kishore Rapolu, and Ganesh Kumar Gudas. "Quality by design guided self-nano emulsifying powder-filled hard gelatin capsules for better oral delivery of haloperidol: In vitro and ex vivo characterization." Journal of Drug Delivery Science and Technology 111 (September 2025): 107186. https://doi.org/10.1016/j.jddst.2025.107186.

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Wu, Fengying, Qing Ma, Guanghui Tian, Kaixian Chen, Rulei Yang, and Jingshan Shen. "Formulation and Evaluation of Solid Self-Nanoemulsifying Drug Delivery System of Cannabidiol for Enhanced Solubility and Bioavailability." Pharmaceutics 17, no. 3 (2025): 340. https://doi.org/10.3390/pharmaceutics17030340.

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Background/Objectives: This study aims to develop a solid self-nanoemulsifying drug delivery system (SNEDDS) to enhance the solubility and oral bioavailability of cannabidiol (CBD). Methods: According to the solubility of CBD and pseudo-ternary phase diagrams of the different ingredients, an oil (medium-chain triglyceride, MCT), mixed surfactants (Labrasol, Tween 80), and a co-surfactant (Transcutol) were selected for the SNEDDS. CBD-loaded SNEDDS formulations were prepared and characterized. The optimal SNEDDS was converted into solid SNEDDS powders via solid carrier adsorption and spray dryi

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Hayashida, Mariko, Yuri Ishii, Tomoki Adachi, Rie Imai, Nobuo Uotsu, and Kei Yui. "Pharmacokinetics of a Single Intake of a Self-Emulsifying Drug Delivery System Containing Triglyceride Form of Docosahexaenoic Acid: A Randomized, Double-blinded, Crossover Study." Current Developments in Nutrition, July 25, 2022. http://dx.doi.org/10.1093/cdn/nzac122.

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Abstract Background Health benefits of n-3 (Omega-3) polyunsaturated fatty acids are well studied. A self-emulsifying drug delivery system (SEDDS) is expected to improve n-3 polyunsaturated fatty acids absorption. Objective The present study investigated how a single ingestion of a new SEDDS containing triglyceride form of docosahexaenoic acid (DHA/TG) would affect the plasma DHA level in healthy participants. Methods Fifteen healthy participants (Age 20–65 years old, BMI, 18.5–25 kg/m2) were enrolled in this randomized, double-blind, crossover study. Participants in a fasting state consumed a

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Yadav, Khushwant, Shivani Arora, Soma Yasaswi, Prabhuti Nirale, Anita Solanki, and Jnanadeva Bhat. "Self-nano-emulsifying drug delivery systems of Atorvastatin Calcium Liquid Filled in Hard Shell Capsules for Improved Oral Bioavailability in Rabbits." Current Nanoscience 19 (April 17, 2023). http://dx.doi.org/10.2174/1573413719666230417085132.

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Aims and Objectives: Atorvastatin calcium (ATR) is a BCS class II drug showing poor bioavailability due to limited aqueous solubility. In the present study, a self-nano-emulsifying drug delivery system (SNEDDS) was developed and formulated as a liquid filled in a hard shell capsule to improve the bioavailability of ATR. Methods: Different oils were screened through the saturated stability method, and the amount of ATR solubilized in the respective oils was analysed through HPLC at 245nm. A ternary phase diagram was plotted to obtain the optimized ratio of oil, surfactant, and co-surfactant to

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"Preparation and in-vitro evaluation of cilostazol self-emulsifying drug delivery system." Al Mustansiriyah Journal of Pharmaceutical Sciences, March 1, 2020, 13–30. http://dx.doi.org/10.32947/ajps.20.01.0436.

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This work reported a first liquid self-nanoemulsifying drug delivery system (SEDD) of cilostazol using oleic acid as oil phase, tween 80 as surfactant, and transcutol as co-surfactant. Cilostazol is a poor water-soluble phosphodiesterase III inhibitor, which has antiplatelet and vasodilator effect used to relief intermittent claudication symptoms. Cilostazol solubility was determined in various oils, surfactants and co-surfactants and phase diagram was constructed at different oil: surfactant: co-surfactant ratios to determine the existence of nano-emulsion region. The in-vitro dissolution pro

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Londhe, Vaishali, and Pooja Bakshi. "Improved oral bioavailability of Febuxostat by liquid self-micro emulsifying drug delivery system in capsule shells." Annales Pharmaceutiques Françaises, May 2023. http://dx.doi.org/10.1016/j.pharma.2023.05.003.

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Chauhan, Abhishek, Raj Kamal, Ritika Mishra, Devank Shekho, and Ankit Awasthi. "A Comprehensive Guide to the Development, Evaluation, and Future Prospects of Self-nanoemulsifying Drug Delivery Systems for Poorly Water-soluble Drugs." Current Pharmaceutical Design 30 (April 5, 2024). http://dx.doi.org/10.2174/0113816128296705240327065131.

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Abstract:: Self-Nano Emulsifying Drug Delivery Systems (SNEDDS) are novel formulations that can enhance the solubility and bioavailability of poorly water-soluble drugs. SNEDDS are composed of lipids, surfactants, co-solvents, and drugs and can spontaneously form nanoemulsions when mixed with water under mild agitation. SNEDDS can be formulated as liquid or solid dosage forms and can improve drug absorption by increasing the interfacial area, protecting the drug from degradation, and facilitating lymphatic transport. SNEDDS is characterized by various parameters such as particle size, zeta pot

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N. Vaja, Payal, Chetan H. Borkhataria, Moinuddin M. Soniwala, and Vidhi K. Matariya. "Development and characterization of self-micro emulsifying drug delivery system of cilnidipine using simplex centroid mixture design." Research Journal of Pharmacy and Technology, August 31, 2023, 3665–72. http://dx.doi.org/10.52711/0974-360x.2023.00603.

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Objective: The main objective of the current research work was development and characterization of self-micro emulsifying drug delivery system of cilnidipine which is poorly water soluble drug. The improved solubility could offer improved dissolution as well as oral bioavailability. Method: Component excipients were selected based on the preliminary studies, capryol 90 and triacetin (1:1) selected as an oil, tween 80 selected as surfactant, transcutol p selected as co-surfactant based on the maximum solubility and better emulsification efficiency. The ternary phase diagram was constructed to i

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Magfirah, Magfirah, Indah Kurnia Utami, I. Dewa Ayu Nurllya K.D, and Niluh Puspita Dewi. "Optimization and Validation Test of Self Nano-emulsifiying Drug Delivery System Capsule of Ethanol Extract Parang Romang Leaves." Ad-Dawaa' Journal of Pharmaceutical Sciences, July 18, 2023, 67–76. http://dx.doi.org/10.24252/djps.v6i1.38469.

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Introdiction: Parang romang contains alkaloids, flavonoids, tannins, and saponins. The secondary metabolites of the leaf extract have low solubility in water. The self-nano emulsifying drug delivery system (SNEDDS) is one solution to increase the solubility of the extract. Aims This study aims to obtain the best formula and ensure that the assay analysis method used can provide accurate and reliable results so that they can be trusted. Methods: Parang romang leaf extract was added to the optimum mixture of tween 20/80, propylene glycol, and olive oil and then characterized including% transmitt

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Thi Huyen, Nguyen, and Vu Thi Thu Giang. "Self-emulsifying drug delivery systems and the application in drugs and cosmetics." VNU Journal of Science: Medical and Pharmaceutical Sciences, June 29, 2023. http://dx.doi.org/10.25073/2588-1132/vnumps.4529.

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Self-emulsifying drug delivery systems (SEDDS) have the potential to enhance the bioavailability and therapeutic impact of active ingredients that are poorly water-soluble, low pemeability and unstable. The active ingredient, oil, surfactant, co-surfactant and/or co-solvent are the main elements of SEDDS. Supersaturable SEDDS have been developed to increase the efficiency of active ingredient loading by incorporating precipitation inhibitors (PIs) into SEDDS that help maintain the supersaturated state, preventing drug precipitation in the gastrointestinal tract. Due to these benefits, SEDDS ha

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Nagaraju, R., Damineni Saritha, P. Subhash Chandra Bose, G. Ravi, and Valluru Ravi. "A REVIEW ON CURRENT STATUS OF SELF-EMULSIFYING DRUG DELIVERY SYSTEMS." International Journal of Medical and Biomedical Studies 3, no. 7 (2019). http://dx.doi.org/10.32553/ijmbs.v3i7.421.

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The modern drug delivery system of hydrophobic drugs presents a main challenge because of the poor aqueous solubility of such compounds. Self emulsifying drug delivery systems (SEDDS) are usually used to enhance the bioavailability of hydrophobic drugs. SEDDS can be administered orally in soft or hard gelatin capsules and form fine relatively stable oil in water (o/w) emulsions upon aqueous dilution due to the gentle agitation of the gastrointestinal fluids. From time to time so many workers have claimed different rational applications of Self-emulsifying formulation for increcing bioavailabil

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Dash, Tapaswi Rani* Sharma Pankaj Sharma Sawati Sood Parul. "NOVEL SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS) FOR ORAL DELIVERY OF LIPOPHILIC DRUGS." January 31, 2017. https://doi.org/10.5281/zenodo.2380887.

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The self-nanoemulsifying drug delivery system (SNEDDS), is a promising Drug Delivery System which is well known for its prospective to improve the aqueous solubility and oral absorption of poorly water soluble drugs (Pouton, 2000). SNEDDS is an isotropic mixture comprising oil, surfactant, co-surfactant and drug that form oil in water emulsion in aqueous environment under placid agitation. It can readily disperse in the aqueous environment of the gastrointestinal tract to form a fine oil-in-water emulsion with a droplet size not exceeding 100 nm under mild agitation for improving the oral bioa

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Kumar, Rajesh, Khushboo Bhardwaj, Arun Sharma, Rajan Kumar, and Verint Tyagi. "Improving Oral Bioavailability of Herbal Drugs: A Focused Review of Self-Emulsifying Drug Delivery System for Colon Cancer." Current Drug Delivery 20 (May 5, 2023). http://dx.doi.org/10.2174/1567201820666230505113108.

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Abstract: One of the most frequent malignancies in the world is colon cancer. Both men and women are affected in the same way. The colon, which makes up the last part of the digestive system and is where water and minerals from food waste are absorbed, is vulnerable to cancer. The most suitable technique of drug administration is oral administration. Aqueous solubility is low in more than 40% of novel chemical entities, resulting in poor oral drug administration. In the formulation of oral medications, low inconsistent bioavailability is a major challenge. Increasing medication bioavailability

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Febi, S. Kuruvila* Flowerlet Mathew S. Kuppuswamy. "SOLID SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) DEVOLOPMENT, APPLICATIONS AND FUTURE PERSPECTIVE: A REVIEW." iajps,csk publications 04, no. 03 (2017). https://doi.org/10.5281/zenodo.495629.

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Developments in recent drug discovery programs, yields a large proportion of novel pharmacologically active molecules that are lipophilic and poorly soluble ,which is a major challenge for pharmaceutical researchers to enhance the oral bioavailability of such drug molecules. Compared to conventional oral dosage forms, Self nanoemulsifying drug delivery systems (SNEDDS) possesses potential advantages like ease of manufacture and scale up, quick onset of action, reduction in drug dose, reduction in inter and intra subject variability and food effects and minimize problems associated with filling

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Wang, Yaru, Yunxia Shang, Fengyu Tang, Kun Qiu, Xiaohui Wei, and Zhengtao Wang. "Self-Double-Emulsifying Drug Delivery System Enteric-Coated Capsules: A Novel Approach to Improve Oral Bioavailability and Anti-inflammatory Activity of Panax notoginseng Saponins." AAPS PharmSciTech 24, no. 4 (2023). http://dx.doi.org/10.1208/s12249-023-02549-0.

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Anand, Sonia, Rishikesh Gupta, and Prajapati Sk. "SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM." Asian Journal of Pharmaceutical and Clinical Research, September 26, 2016, 33. http://dx.doi.org/10.22159/ajpcr.2016.v9s2.13180.

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<p>ABSTRACT<br />Oral route is the most convenient route of drug administration in many diseases and till today it is the first way investigated in the development of<br />new dosage forms. The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility,<br />thereby pretense problems in their formulation. More than 40% of potential drug products suffer from poor water solubility. For the therapeutic<br />delivery of lipophilic active moieties (biopharmaceutical classification system Class II drugs)

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Singh, Neeraj, Shweta Rai, and Sankha Bhattacharya. "A Conceptual Analysis of solid Self-emulsifying drug Delivery System and its Associate Patents for the Treatment of Cancer." Recent Patents on Nanotechnology 14 (September 9, 2020). http://dx.doi.org/10.2174/1872210514666200909155516.

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Background: About two-third of new drugs reveal low solubility in water due to that; it becomes difficult for formulation scientists to develop oral solid dosage forms with a pharmaceutically acceptable range of therapeutic activity. In such cases, S-SMEEDS are the best carrier used universally for the delivery of hydrophobic drugs. SEDDS were also used, but due to its limitations, S-SMEDDS used widely. These are the isotropic mixtures of oils, co-solvents, and surfactants. S-SMEDDS are physically stable, easy to manufacture, easy to fill in gelatin capsules as well as improves the drug bioava

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Rashid Iqbal, Mohammad. "Gastric Floating Drug Delivery Systems: A Promising Carriers for The Delivery of Controlled Release Drugs." International Journal of Life Science and Pharma Research, December 31, 2022, P127—P136. http://dx.doi.org/10.22376/ijlpr.2023.13.1.sp1.p127-p136.

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Abstract: Low density systems or adaptively coordinated systems that has enough buoyancy to float on over contents of the stomach for a significant length of time without noticeably decelerating the rate of gastric emptying are known as floating systems. To accomplish stomach retention, the principle process of flotation was specifically examined in this drug delivery system. It is advantageous to construct medications in an oral sustained release gastro-retentive dose form for those that are absorbed in the upper portions of the GIT. The development of dynamically controlled systems depends o

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