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Relevant bibliographies by topics / Self emulsifying drug delivery system (SEDDS); oil

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Academic literature on the topic 'Self emulsifying drug delivery system (SEDDS); oil'

Author: Grafiati

Published: 3 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Self emulsifying drug delivery system (SEDDS); oil"

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L., Ramanamma *. Suvendu Kumar Sahoo Sharmila Dusi D.S.V.S. Prasad. "FORMULATION AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM FOR BCS CLASS – II DRUGS USING TRIMETHOPRIM AS A MODEL DRUG." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 07 (2018): 6733–54. https://doi.org/10.5281/zenodo.1319748.

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<em>Oral route is the easiest and most convenient route for drug administration. Oral drug delivery systems being the most cost-effective and leads the worldwide drug delivery market. The major problem in or it get solubility and then absorbedoral route is a problematic route for those drug molecules which exhibit poor aqueous solubility. When a drug is administrered by oral route the first step for it to get solubilized and then absorbed . formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility. This may lead to high inter- and intra subject variabil

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Essien, E. S., T. C. Jackson, E. O. Olorunsola, and E. O. Olorunsola. "Development and Evaluation of Encapsulated Self-Emulsifying Drug Delivery System of Hydrochlorothiazide." Nigerian Journal of Pharmaceutical Research 20, no. 1 (2024): 23–30. http://dx.doi.org/10.4314/njpr.v20i1.3.

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Background: Formulation of solid self-emulsifying drug delivery system (Solid SEDDS) provides a dual benefit of improved drug stability and enhanced delivery system. Objective: This study was aimed at developing and evaluating a solid self-emulsifying drug delivery system of hydrochlorothiazide. Methods: Solubility of hydrochlorothiazide in some oils was determined and pseudo-ternary system of the most effective oil, water and surfactant system was constructed. Four Liquid SEDDSs were formulated to contain Tween 80/oleic acid or PEG 400/oleic acid (surfactant systems) and castor oil combined i

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Bhattacharya, Sankha. "Self-Emulsifying Drug Delivery System (SEDDS) and its Pharmaceutical Applications." Applied Clinical Research, Clinical Trials and Regulatory Affairs 7, no. 3 (2020): 206–24. http://dx.doi.org/10.2174/2213476x07666200827102951.

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Poor aqueous solubility, oral bioavailability, inter, and inter-subject variability, and physical stability have always been a concern for pharmaceutical formulation scientists while formulating an oral dosage form. Self-Emulsifying Drug Delivery System (SEDDS) is a promising new approach to mitigating those potential problems. The main advantages of SEDDS are that it increases the solubility and decreases the bio-degradation of lipophilic drugs. Mostly BCS II & IV Class drugs are preferable. SEDDS is an admixture of drugs, oil, surfactants, cosolvents, and stabilizers. With little energy

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Verma, Rakhi, Kamal Singh Rathore, and Surendra Singh Saurabh. "Review article on self emulsifying system." IP International Journal of Comprehensive and Advanced Pharmacology 9, no. 3 (2024): 196–201. http://dx.doi.org/10.18231/j.ijcaap.2024.027.

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The solubility challenges faced by the pharmaceutical industry, particularly with orally administered drugs, are indeed significant. Low aqueous solubility often leads to poor dissolution and subsequently, low bioavailability, which can result in inconsistent drug effects among patients. Various methods have been explored to address this issue, including salt formation, solid dispersion, and complex formation.Among these approaches, Self-Emulsifying Drug Delivery Systems (SEDDS) have emerged as a promising solution for enhancing the solubility of lipophilic drugs. SEDDS consist of isotropic mi

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Deshmukh, Suwarna R., Suparna S. Bakhle, Kanchan P. Upadhye, and Gouri R. Dixit. "FORMULATION AND EVALUATION OF SOLID SELF-EMULSIFYING DRUG DELIVERY SYSTEM OF GLICLAZIDE." International Journal of Pharmacy and Pharmaceutical Sciences 8, no. 11 (2016): 144. http://dx.doi.org/10.22159/ijpps.2016v8i11.14104.

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Objective: Gliclazide (GCZ) is a widely prescribed anti-diabetic drug belongs to class IΙ under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. The present investigations highlight the development of solid self-emulsifying drug delivery system (solid-SEDDS) for improved oral delivery of the poorly water-soluble drug, GCZ.Methods: Various oils, surfactant and co-surfactant, were screened for their emulsification ability. Ternary phase diagrams were plotted to identify the zone of micro-emulsification. Liquid SEDDS of the drug were formulated using lemon

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Sneha Latha, K., G. B. Kiran Kumar, G. A. Mohammed, S. K. Chowdary, and J. Sowmya. "FORMULATION AND EVALUATION OF LIPID BASED SELF EMULSIFYING DRUG DELIVERY SYSTEM OF GLIMEPIRIDE." INDIAN DRUGS 50, no. 11 (2013): 48–51. http://dx.doi.org/10.53879/id.50.11.p0048.

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Aim of the present investigation was to develop lipid based self-emulsifying drug delivery system (SEDDS) to improve bioavailability of glimepiride. Glimepiride is a class II molecule according to BCS (Biopharmaceutical Classification System), having low solubility. Optimized self-emulsifying drug delivery system of glimepiride comprising oil (oleic acid), surfactant (Tween 80®) and co-surfactant (PEG 200®) was prepared. Optimized SEDDS of glimepiride showed increase in dissolution rate. It was concluded that the formulation was found to be showing significant improvement in terms of the drug

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Mantry, Shubhrajit, and Debasmita Majumder. "Development of Liquid and Solid Self-Emulsifying Drug Delivery System of Silymarin." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 54–61. http://dx.doi.org/10.22270/jddt.v9i3-s.2754.

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The objective of our investigation was to formulate a self-emulsifying drug delivery system (SEDDS) of Silymarin using minimum surfactant concentration that could include its solubility, stability and also oral bioavailability. Silymarin are widely use drug for the treatment of hepatitis C virus, have poor bioavailability due to their poor water solubility that limits dissolution rate. To overcome this limitation SEDDS were prepared to attempt their release property. The solubility of the drug was determined by various vehicles. Ternary phase diagram was constructed using Cinnamon (oil), Tween

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Trajanovska, Eleonora, Maja Simonoska Crcarevska, Miroslav Mirchev, et al. "Optimization of self-emulsifying drug delivery system of cefuroxime axetil." Macedonian Pharmaceutical Bulletin 66, no. 2 (2021): 67–79. http://dx.doi.org/10.33320/maced.pharm.bull.2020.66.02.007.

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Abstract Overcoming solubility problems is the greatest challenge during formulation of poorly soluble active pharmaceutical ingredients (API’s) into oral solid dosage forms. Different formulation approaches were used to surpass this problem and enhance their solubility in the gastrointestinal (GI) fluids, in order to achieve a faster dissolution and better absorption, which will directly influence their therapeutic effect. In this paper, an evaluation of the potential of a self-emulsifying drug delivery system (SEDDS) to improve the solubility of the active ingredient cefuroxime axetil (CA) w

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Thakare, Priya, Vrushali Mogal, Jaydeep Dusane, and Sanjay Kshirsagar. "A review on self-emulsified drug delivery system." Pharmaceutical and Biological Evaluations 3, no. 2 (2016): 140–53. https://doi.org/10.5281/zenodo.51056.

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Improving oral bioavailability of low poorly water soluble drugs using self-emulsifying drug delivery systems (SEDDS) possess significant potential. Oral bioavailability of hydrophobic drugs can be improved using SEDDS, and appears most promising. Their dispersion in gastro intestinal (GI) fluid after administration forms micro or nano emulsified drug which gets easily absorbed through lymphatic pathways bypassing the hepatic first pass metabolism. Parameters like surfactant concentration, oil to surfactant ratio, polarity of emulsion, droplet size and charge on droplet plays a critical role i

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Anant, Kumar, Singh Anupam, Kumar Saket, et al. "A Review of Self-Emulsifying Drug Delivery System- A Novel Approach to Drug." Pharmaceutical and Chemical Journal 12, no. 2 (2025): 148–58. https://doi.org/10.5281/zenodo.15606878.

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A combination of oils, surfactants, and co-surfactants are re-emulsified in aqueous media while being gently stirred and subjected to the same digestive motility that occurs in the gastrointestinal tract in a self-emulsifying drug delivery system. One method for enhancing the oral bioavailability of hydrophobic medications is SEDDS. It is possible to transform the liquid SEDDS into a solid dosage form without compromising the drug release characteristics. The hepatic first-pass effect is circumvented by the micro/nano-emulsified drug's small size, which makes it simple to absorb through lympha

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Dissertations / Theses on the topic "Self emulsifying drug delivery system (SEDDS); oil"

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Patel, Manisha Jagdishchandra. "The formulation and characterisation of polyglycolysed glyceride self-emulsifying drug delivery systems." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326220.

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Challis, Deborah. "Physicochemical and biopharmaceutical studies of novel self-emulsifying systems for administration by the oral route (SEDDS)." Thesis, University of Bath, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280871.

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Book chapters on the topic "Self emulsifying drug delivery system (SEDDS); oil"

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Talele, Swati Gokul, Eknath Damu Ahire, Gokul Shravan Talele, and Deelip Vasantrao Derle. "An Innovative Approach as Self-Emulsifying Drug Delivery System for Phytoconstituents." In Advances in Medical Diagnosis, Treatment, and Care. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-4453-2.ch003.

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In recent years, herbal drugs have flourished as the method of rehabilitation of choice in numerous parts of the world and most of populations consider them as alternative conventional medicaments. However, most of the herbal drugs show poor solubility and bioavailability, which ultimately leads to diminished efficacy and frequency of administration. Consequently, self-emulsifying drug delivery system has been highlighted for poor water-soluble herbal medicaments. Self-emulsifying drug delivery system is an isotropic mixture of phytoconstituents, oil, surfactant, and cosurfactant, and subseque

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Mohanty, Biswaranjan, Amulyaratna Behera, Tapan Kumar Shaw, Sk Habibullah, and Biswajeet Acharya. "Soybean Oil: A Versatile Asset in Pharmaceutical Drug Delivery." In Agricultural Sciences. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.115033.

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Soybean oil (SO), a lucrative and widely utilized vegetable oil, is used not only in the pharmaceutical industry but also to produce green diesel and several biomedical applications. SO is rich in healthy fats, including linoleic acid (54%), oleic acid (23%), palmitic acid (11%), linolenic acids (8%), and stearic acid (4%). Its high unsaturated fatty acid content makes it ideal for medicinal purposes. In topical application, SO provides anti-inflammatory and soothing benefits. The presence of SO in lipid-based medication improves the therapeutic efficacy and bioavailability of poorly water-sol

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S, Harer Priyanka, and Harer Sunil L. "DEVELOPMENT AND EVALUATION OF A SELF-MICRO EMULSIFYING OMEGA-3 FATTY ACID DRUG DELIVERY SYSTEM USING FLAXSEED OIL." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 7. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bapn7p1ch11.

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Self micro-emulsifying drug delivery system is the mixture of oils, surfactants, and cosurfactants, which are emulsified in aqueous media under conditions of gentle agitation and digestive motility that would be encountered in the gastro-intestinal (GI) tract that leads improve the solubility, bioavailability and biocompatibility. Purpose of this work is to prepare self-microemulsifying drug delivery system (SMEDDS) to enhance the oral bioavailability and stability of linseed oil (Omega-3 fatty acid). Linseed contains very high amount of omega-3 fatty acid (55-60%). Solubility of linseed oil (

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Galgatte, Upendra, Parth Gharat, Yugandhar Pulichera, and M. Kalyan Kumar Raju. "MOLECULAR MECHANISM OF BIOACTIVE COMPOUNDS." In Futuristic Trends in Herbal Medicines and Food Products. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/nbennurch251.

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Herbal compounds are secondary metabolites that are derived from various plant parts. These herbal compounds hold an upper hand in terms of chemical as well as pharmacological diversity which isbeyond the limits of current synthetic chemistry. Till now, more than a thousand small molecules have been approved, of which 60% are drug substances and most of the approved drugs are either coming from nature or inspired from herbal compounds. Moreover, nature will still dominate to be a vital resource of molecular complexity-diversity, for the development of new chemical entities. Many investigations

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Conference papers on the topic "Self emulsifying drug delivery system (SEDDS); oil"

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Wahyuningsih, Iis, and Hani Pertiwi Khoirunnisa. "The Effects of SNEDDS (Self-Nano Emulsifying Drug Delivery System) Black Cumin Oil Seeds (Nigella sativa L) to The Histopatology of Lung Organs of The Sprague Dawley Rats That Induced by DMBA." In Proceedings of the 2019 Ahmad Dahlan International Conference Series on Pharmacy and Health Science (ADICS-PHS 2019). Atlantis Press, 2019. http://dx.doi.org/10.2991/adics-phs-19.2019.4.

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