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Journal articles on the topic 'Self Expression Benefit'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Tracy, Dale. "Veterans’ self-expression in poetry." Journal of Military, Veteran and Family Health 7, no. 1 (2021): 108–12. http://dx.doi.org/10.3138/jmvfh-2020-0005.

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LAY SUMMARY Research shows that Veterans benefit from writing poetry for therapeutic purposes. This article suggests the need for future research that considers the effects of the artistic choices that Veterans make when using poetry to engage their experiences. The author focuses on one Veteran’s poem about what it means to write poetry as a Veteran. Brian Turner’s “Here, Bullet” comes from his poetry collection about his time as an American infantry team leader in Iraq. This poem centres on a solider whose body is in danger in a conflict setting. The poem becomes an alternative space to his

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Imami, Ledina, Sarah C. E. Stanton, Samuele Zilioli, et al. "Self-Disclosure and Perceived Responsiveness Among Youth With Asthma: Links to Affect and Anti-Inflammatory Gene Expression." Personality and Social Psychology Bulletin 45, no. 8 (2018): 1155–69. http://dx.doi.org/10.1177/0146167218808497.

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Self-disclosure and perceived responsiveness are important building blocks of social relationships that have long-lasting consequences for health and well-being. However, the conditions under which self-disclosure and responsiveness are likely to benefit health, and how early in life these benefits arise, remain unclear. Among 141 youth (aged 10-17) with asthma, we investigated how average daily levels of self-disclosure and responsiveness are linked to positive and negative affect and the expression of the glucocorticoid receptor gene NR3C1, a marker of improved regulation of stress physiolog

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Stanton, Annette L., Sharon Danoff-Burg, Lisa A. Sworowski, et al. "Randomized, Controlled Trial of Written Emotional Expression and Benefit Finding in Breast Cancer Patients." Journal of Clinical Oncology 20, no. 20 (2002): 4160–68. http://dx.doi.org/10.1200/jco.2002.08.521.

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PURPOSE: Expressing emotions and finding benefits regarding stressful experiences have been associated in correlational research with positive adjustment. A randomized trial was performed to compare effects of experimentally induced written emotional disclosure and benefit finding with a control condition on physical and psychological adjustment to breast cancer and to test whether outcomes varied as a function of participants’ cancer-related avoidance. PATIENTS AND METHODS: Early-stage breast cancer patients completing medical treatment were assigned randomly to write over four sessions about

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Subiantoro, Monica. "Musical Improvisation for Promoting Parent-Child Interaction." ANIMA Indonesian Psychological Journal 32, no. 3 (2017): 148–57. http://dx.doi.org/10.24123/aipj.v32i3.629.

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This study aims to examine parents' experiences on improvisation and investigate how it contributes to the development of parent-child interaction in a music therapy group. Using qualitative method, it involves a questionnaire, semi-structured interview and observation on musical behavior through video analysis. The result shows that although parents initially feel hesitant to respond to this new activity, parents and children benefit from having improvised music in the session. The benefits include increasing spontaneity, self-expression without language barriers, allowing parents to interact

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Papista, Erifili, and Sergios Dimitriadis. "Consumer – green brand relationships: revisiting benefits, relationship quality and outcomes." Journal of Product & Brand Management 28, no. 2 (2019): 166–87. http://dx.doi.org/10.1108/jpbm-09-2016-1316.

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PurposeThe study aims to develop and test a relationship-building model for green brands. It synthesizes findings on the consumer motives offered by green brands, with relationship marketing and branding literature to the specific context of green brands to build a parsimonious model testing the links amongst four relational benefits, i.e. confidence, socialization, self-expression and altruism; two relational mediators, i.e. satisfaction and relationship quality; three behavioural outcomes, i.e. word-of-mouth, expectation of continuity and cross-buying; and two moderators of the benefits-medi

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Cortes, Kassandra, Joanne V. Wood, and Jill Prince. "Repairing one’s mood for the benefit of others: Agreeableness helps motivate low self-esteem people to feel better." Journal of Social and Personal Relationships 36, no. 11-12 (2019): 3835–54. http://dx.doi.org/10.1177/0265407519840707.

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The chronic experience and expression of negativity is associated with poorer personal and relationship outcomes. Unfortunately, compared to people with high self-esteem, those with low self-esteem (LSEs) are less motivated to repair their negative moods. The current research examined mood repair in a novel way: in a close relationship context, when mood repair centers on benefitting others. We hypothesized that LSEs are more motivated than usual to repair negative moods when doing so benefits close others and when high in agreeableness (a trait involving prosocial motivation). We found suppor

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Khan, Imran S., Maria L. Mouchess, Meng-Lei Zhu, et al. "Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance." Journal of Experimental Medicine 211, no. 5 (2014): 761–68. http://dx.doi.org/10.1084/jem.20131889.

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Thymic central tolerance is a critical process that prevents autoimmunity but also presents a challenge to the generation of anti-tumor immune responses. Medullary thymic epithelial cells (mTECs) eliminate self-reactive T cells by displaying a diverse repertoire of tissue-specific antigens (TSAs) that are also shared by tumors. Therefore, while protecting against autoimmunity, mTECs simultaneously limit the generation of tumor-specific effector T cells by expressing tumor self-antigens. This ectopic expression of TSAs largely depends on autoimmune regulator (Aire), which is expressed in mature

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Guan, Jian, Khin Sandar Lim, Tarek Mekhail, and Chung-Che Chang. "Programmed Death Ligand-1 (PD-L1) Expression in the Programmed Death Receptor-1 (PD-1)/PD-L1 Blockade: A Key Player Against Various Cancers." Archives of Pathology & Laboratory Medicine 141, no. 6 (2017): 851–61. http://dx.doi.org/10.5858/arpa.2016-0361-ra.

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Context.— Immune checkpoint pathways, including programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1) signaling pathway, which are important in mediating self-tolerance and controlling self-damage, can sometimes be manipulated by cancer cells to evade immune surveillance. Recent clinical trials further demonstrate the efficacy of PD-1/PD-L1–targeted therapy in various cancers and reveal a new era of cancer immunotherapy. Objective.— To review the mechanism of the PD-1/PD-L1 signaling pathway, the regulation of this pathway, PD-1/PD-L1 as a predictive and/or prognostic marker in va

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Prechl, József. "Why current quantitative serology is not quantitative and how systems immunology could provide solutions." Biologia Futura 72, no. 1 (2021): 37–44. http://dx.doi.org/10.1007/s42977-020-00061-1.

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AbstractDetermination of the presence of antibodies against infectious agents, self-antigens, allogeneic antigens and environmental antigens is the goal of medical serology. Along with the standardization of these tests the community also started to use the expression “quantitative serology,” referring to the fact that arbitrary units are used for the expression of results. In this review I will argue against the use of the term quantitative serology for current tests. Because each test and each antibody isotype determination uses its own references, the term semiquantitative better describes

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Hui, Ada, Theodore Stickley, Michelle Stubley, and Francesca Baker. "Project eARTh: participatory arts and mental health recovery, a qualitative study." Perspectives in Public Health 139, no. 6 (2019): 296–302. http://dx.doi.org/10.1177/1757913918817575.

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Aims: To identify the potential mental health benefits of a rural-based participatory arts programme in the United Kingdom. Methods: Fourteen narrative interviews were conducted among participants of the Project eARTh programme. The data were subjected to a thematic analysis process. Results: Three overarching themes were identified: identity and self-expression; connectedness through occupation; wellbeing and personal growth. The importance of meaningful relationships was highlighted as preventing social isolation, particularly in rural locations. Engagement in artistic group activities enabl

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Efremova, Maria V., Silviu-Vasile Bodea, Felix Sigmund, Alevtina Semkina, Gil G. Westmeyer, and Maxim A. Abakumov. "Genetically Encoded Self-Assembling Iron Oxide Nanoparticles as a Possible Platform for Cancer-Cell Tracking." Pharmaceutics 13, no. 3 (2021): 397. http://dx.doi.org/10.3390/pharmaceutics13030397.

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The study of growth and possible metastasis in animal models of tumors would benefit from reliable cell labels for noninvasive whole-organism imaging techniques such as magnetic resonance imaging. Genetically encoded cell-tracking reporters have the advantage that they are contrast-selective for viable cells with intact protein expression machinery. Besides, these reporters do not suffer from dilution during cell division. Encapsulins, which are bacterial protein nanocompartments, can serve as genetically controlled labels for multimodal detection of cells. Such nanocompartments can host vario

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Guiducci, Cristiana, Mei Gong, Alma-Martina Cepika, et al. "RNA recognition by human TLR8 can lead to autoimmune inflammation." Journal of Experimental Medicine 210, no. 13 (2013): 2903–19. http://dx.doi.org/10.1084/jem.20131044.

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Studies on the role of the RNA receptor TLR8 in inflammation have been limited by its different function in human versus rodents. We have generated multiple lines of transgenic mice expressing different levels of human TLR8. The high copy number chimeras were unable to pass germline; developed severe inflammation targeting the pancreas, salivary glands, and joints; and the severity of the specific phenotypes closely correlated with the huTLR8 expression levels. Mice with relatively low expression levels survived and bred successfully but had increased susceptibility to collagen-induced arthrit

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Sands, Timothy. "Development of Deterministic Artificial Intelligence for Unmanned Underwater Vehicles (UUV)." Journal of Marine Science and Engineering 8, no. 8 (2020): 578. http://dx.doi.org/10.3390/jmse8080578.

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The major premise of deterministic artificial intelligence (D.A.I.) is to assert deterministic self-awareness statements based in either the physics of the underlying problem or system identification to establish governing differential equations. The key distinction between D.A.I. and ubiquitous stochastic methods for artificial intelligence is the adoption of first principles whenever able (in every instance available). One benefit of applying artificial intelligence principles over ubiquitous methods is the ease of the approach once the re-parameterization is derived, as done here. While the

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Newman, Zachary R., Janet M. Young, Nicholas T. Ingolia, and Gregory M. Barton. "Differences in codon bias and GC content contribute to the balanced expression of TLR7 and TLR9." Proceedings of the National Academy of Sciences 113, no. 10 (2016): E1362—E1371. http://dx.doi.org/10.1073/pnas.1518976113.

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The innate immune system detects diverse microbial species with a limited repertoire of immune receptors that recognize nucleic acids. The cost of this immune surveillance strategy is the potential for inappropriate recognition of self-derived nucleic acids and subsequent autoimmune disease. The relative expression of two closely related receptors, Toll-like receptor (TLR) 7 and TLR9, is balanced to allow recognition of microbial nucleic acids while limiting recognition of self-derived nucleic acids. Situations that tilt this balance toward TLR7 promote inappropriate responses, including autoi

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Nguyen, Le Van, Ba Cao Nguyen, Xuan Nam Tran, and Le The Dung. "Closed-Form Expression for the Symbol Error Probability in Full-Duplex Spatial Modulation Relay System and Its Application in Optimal Power Allocation." Sensors 19, no. 24 (2019): 5390. http://dx.doi.org/10.3390/s19245390.

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Full-duplex (FD) communication and spatial modulation (SM) are two promising techniques to achieve high spectral efficiency. Recent works in the literature have investigated the possibility of combining the FD mode with SM in the relay system to benefit their advantages. In this paper, we analyze the performance of the FD-SM decode-and-forward (DF) relay system and derive the closed-form expression for the symbol error probability (SEP). To tackle the residual self-interference (RSI) due to the FD mode at the relay, we propose a simple yet effective power allocation algorithm to compensate for

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NICKEL, C., S. TANCA, S. KOLOWOS, et al. "Men with chronic occupational stress benefit from behavioural/psycho-educational group training: a randomized, prospective, controlled trial." Psychological Medicine 37, no. 8 (2006): 1141–49. http://dx.doi.org/10.1017/s0033291706009445.

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ABSTRACTBackgroundOverworking is one of the most frequent stressors. The purpose of this study was to determine the effectiveness of behavioural/psycho-educational group training in men who are chronically stressed from overworking.MethodOf 72 male subjects, 36 were randomly assigned to training for 8 weeks and another 36 formed the control group, which received a placebo intervention. Primary outcome measures were systolic blood pressure, salivary cortisol concentration upon awakening, and self-reported changes on the scales of the Trier Inventory for the Assessment of Chronic Stress (TICS),

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Sakr, Naomi. "Enriching or Impoverishing Discourse on Rights? Talk about Freedom of Expression on Arab Television." Middle East Journal of Culture and Communication 3, no. 1 (2010): 101–19. http://dx.doi.org/10.1163/187398609x12584657078240.

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AbstractThere is more to the denial of freedom of expression than outright censorship. The right to freedom of expression is interdependent with, and indivisible from, other rights guaranteed under the Universal Declaration of Human Rights. To discuss freedom of expression narrowly as if it were self-contained, and to conceal the issues, processes, and conflicts implicit in its achievement, can be seen as a hegemonic strategy that serves relations of domination. Three sets of public exchanges analyzed here, conducted on and about Arab television against a background of growing international in

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Muslim, Ahmad Bukhori, Herli Salim, and Sri Setyarini. "Indonesian parental perspectives of international school partnerships involving millennial learners." Journal of Research in International Education 19, no. 2 (2020): 106–19. http://dx.doi.org/10.1177/1475240920954051.

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Despite being long-standing practice among schools across the world, most studies on international school partnerships focus on its benefits and challenges as perceived by teachers and students. Little emphasis has been given to parental perspectives and support, particularly among low-income families. With the increase of community involvement in education, how this partnership program may benefit the foreign language learning of millennials has become a matter of increasing concern among parents. This qualitative study explores Indonesian parents’ perspectives of international school partner

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Çalikuşu, Celal, Başak Yücel, Aslihan Polat, and Can Baykal. "Expression of Anger and Alexithymia in Patients with Psychogenic Excoriation: A Preliminary Report." International Journal of Psychiatry in Medicine 32, no. 4 (2002): 345–52. http://dx.doi.org/10.2190/22lb-hl0u-cpjp-wn6a.

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Objective: Psychogenic excoriation (PE), which is characterized by lesions formed by self-picking, has a significant place among the dermatoses related to psychological factors. Emotions, particularly anger that cannot be expressed, may be important in the etiology. The objective of this study was to evaluate the sociodemographic characteristics of patients with PE and with another psychodermatosis, and compare them in terms of anger, manner of anger expression, and alexithymia. Methods: Thirty-one consecutive subjects with PE and thirty-one patients with chronic urticaria were recruited from

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Sharma, A., S. M. Shah, N. Saini, et al. "230 EFFECT OF DIFFERENT CONCENTRATIONS OF GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR ON EXPRESSION OF SELF-RENEWAL RELATED GENES IN GOAT (CAPRA HIRCUS) SPERMATOGONIAL STEM CELLS." Reproduction, Fertility and Development 28, no. 2 (2016): 246. http://dx.doi.org/10.1071/rdv28n2ab230.

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Glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor-β superfamily produced by Sertoli cells, is essential for the self-renewal of spermatogonial stem cells in vivo. The present study evaluated the effects of different concentrations of GDNF (human recombinant expressed in Escherichia coli) on expression of some self-renewal related genes in spermatogonial stem cells (SSC). The SSC were isolated from prepubertal goat testes (3–6 months of age) by using double enzymatic digestion method and filtration through 80- and 60-µm nylon mesh filters. Further en

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Allen, Jennifer L., Maree J. Abbott, Ronald M. Rapee, and Max Coltheart. "Ew gross! Recognition of Expressions of Disgust by Children With Obsessive–Compulsive Disorder." Behaviour Change 23, no. 4 (2006): 239–49. http://dx.doi.org/10.1375/bech.23.4.239.

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AbstractThere is evidence suggesting that obsessive–compulsive disorder (OCD) in adults may be associated with an impaired ability to recognise the facial expression of disgust (Sprengelmeyer et al., 1997a; Woody, Corcoran, & Tolin, in press). It has been suggested that this impairment begins in childhood when the recognition of emotional expressions is being learnt (see Spengelmeyer et al., 1997a). This study compared the recognition of facial affect in children aged around 11 years with a diagnosis of obsessive–compulsive disorder (OCD; n = 11), other anxiety disorders (n = 20), and nonc

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Meza Guzman, Lizeth G., Narelle Keating, and Sandra E. Nicholson. "Natural Killer Cells: Tumor Surveillance and Signaling." Cancers 12, no. 4 (2020): 952. http://dx.doi.org/10.3390/cancers12040952.

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Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate ability to detect and kill tumorigenic cells. The decision to kill is determined by the expression of a myriad of activating and inhibitory receptors on the NK cell surface. Cell-to-cell engagement results in either self-tolerance or a cytotoxic response, governed by a fine balance between the signaling cascades downstream of the activating and inhibitory receptors. To evade a cytotoxic immune response, tumor cells can modulate the surface expression of receptor ligands and additionally, alter the conditi

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Steiger, Howard, and Linda Booij. "Eating Disorders, Heredity and Environmental Activation: Getting Epigenetic Concepts into Practice." Journal of Clinical Medicine 9, no. 5 (2020): 1332. http://dx.doi.org/10.3390/jcm9051332.

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Epigenetic mechanisms are believed to link environmental exposures to alterations in gene expression, and in so doing, to provide a physical substrate for the activation of hereditary potentials by life experiences. In keeping with this idea, accumulating data suggest that epigenetic processes are implicated in eating-disorder (ED) etiology. This paper reviews literature on putative links between epigenetic factors and EDs, and examines ways in which epigenetic programming of gene expression could account for gene-environment interactions acting in the EDs. The paper also presents evidence sug

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Murat, Anastasia, Eugenia Migliavacca, Thierry Gorlia, et al. "Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma." Journal of Clinical Oncology 26, no. 18 (2008): 3015–24. http://dx.doi.org/10.1200/jco.2007.15.7164.

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Purpose Glioblastomas are notorious for resistance to therapy, which has been attributed to DNA-repair proficiency, a multitude of deregulated molecular pathways, and, more recently, to the particular biologic behavior of tumor stem-like cells. Here, we aimed to identify molecular profiles specific for treatment resistance to the current standard of care of concomitant chemoradiotherapy with the alkylating agent temozolomide. Patients and Methods Gene expression profiles of 80 glioblastomas were interrogated for associations with resistance to therapy. Patients were treated within clinical tri

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Fukuda, Seiji, Pratibha Singh, Akira Moh, et al. "Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3." Blood 114, no. 2 (2009): 394–403. http://dx.doi.org/10.1182/blood-2008-11-188714.

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Abstract Internal tandem duplication mutations in the Flt3 tyrosine kinase gene (ITD-Flt3) and overexpression of Survivin are frequently found in patients with acute myeloid leukemia (AML). We investigated whether Survivin mediates the enhanced survival of primary hematopoietic progenitor cells (HPCs) resulting from ITD-Flt3 signaling. Ectopic ITD-Flt3 mutants increased Survivin expression in Ba/F3 cells downstream of PI3-kinase/Akt. Treatment of ITD-Flt3+ human MV4-11 leukemia cells with the ITD-Flt3 inhibitor SU5416 reduced Survivin expression and inhibited cell proliferation. ITD-Flt3 drama

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Zhu, Ying-Gang, Jie-Ming Qu, Jing Zhang, Hong-Ni Jiang, and Jin-Fu Xu. "Novel Interventional Approaches for ALI/ARDS: Cell-Based Gene Therapy." Mediators of Inflammation 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/560194.

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Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), continue to be a major cause of morbidity and mortality in critically ill patients. The present therapeutic strategies for ALI/ARDS including supportive care, pharmacological treatments, and ventilator support are still controversial. More scientists are focusing on therapies involving stem cells, which have self-renewing capabilities and differentiate into multiple cell lineages, and, genomics therapy which has the potential to upregulate expression of anti-inflammatory mediators. Recently, the combi

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Liu, Sheng, Fenglei Zhu, Miaojun Lai, Limin Sun, Yijun Liu, and Wenhua Zhou. "Electroacupuncture Suppresses Discrete Cue-Evoked Heroin-Seeking and Fos Protein Expression in the Nucleus Accumbens Core in Rats." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/286404.

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Relapse to drug seeking was studied using a rodent model of reinstatement induced by exposure to drug-related cues. Here, we used intravenous drug self-administration procedures in rats to further investigate the beneficial effects of electroacupuncture (EA) on heroin-seeking behavior in a reinstatement model of relapse. We trained Sprague-Dawley rats to nose-poke for i.v. heroin either daily for 4 h or 25 infusions for 14 consecutive days. Then the rats were abstinent from heroin for two weeks. 2 Hz EA stimulation was conducted once daily for 14 days during heroin abstinence. We tested these

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Chatterjee, Sumanta, Pratima Basak, Prosun Das, et al. "Primitive Sca-1 Positive Bone Marrow HSC in Mouse Model of Aplastic Anemia: A Comparative Study through Flowcytometric Analysis and Scanning Electron Microscopy." Stem Cells International 2010 (2010): 1–7. http://dx.doi.org/10.4061/2010/614395.

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Self-renewing Hematopoietic Stem Cells (HSCs) are responsible for reconstitution of all blood cell lineages. Sca-1 is the “stem cell antigen” marker used to identify the primitive murine HSC population, the expression of which decreases upon differentiation to other mature cell types.Sca-1+HSCs maintain the bone marrow stem cell pool throughout the life. Aplastic anemia is a disease considered to involve primary stem cell deficiency and is characterized by severe pancytopenia and a decline in healthy blood cell generation system. Studies conducted in our laboratory revealed that the primitiveS

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Fukuda, Seiji, Pratibha Sigh, Edward M. Conway, Seiji Yamaguchi, and Louis M. Pelus. "Survivin Regulates Aberrant Proliferation of Hematopoietic Progenitor Cells with Self Renewal Capability and Development of Acute Leukemia Induced by Internal-Tandem-Duplication of Flt3." Blood 110, no. 11 (2007): 599. http://dx.doi.org/10.1182/blood.v110.11.599.599.

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Abstract Internal Tandem Duplication mutations in the Flt3 tyrosine kinase gene (ITD-Flt3) and over-expression of the inhibitor of apoptosis protein Survivin are frequently found in patients with acute myeloid leukemia (AML) and are associated with poor prognosis. We have shown that ITD-Flt3 increases expression of Survivin in Ba/F3 cells and that antagonizing Survivin inhibits growth factor independent proliferation of primary mouse hematopoietic stem and progenitor cells (HSPC) expressing ITD-Flt3 (Fukuda et al. ASH, 2005). This suggests that Survivin may regulate proliferation of AML cells

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Carrette, Lieselot L. G., Roy Blum, Weiyuan Ma, Raymond J. Kelleher, and Jeannie T. Lee. "Tsix–Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function." Proceedings of the National Academy of Sciences 115, no. 32 (2018): 8185–90. http://dx.doi.org/10.1073/pnas.1800931115.

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Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by a mutation in the X-linked methyl-CpG-binding protein 2 (MECP2). There is currently no disease-specific treatment, but MECP2 restoration through reactivation of the inactive X (Xi) has been of considerable interest. Progress toward an Xi-reactivation therapy has been hampered by a lack of suitable female mouse models. Because of cellular mosaicism due to random X-chromosome inactivation (XCI), Mecp2+/− heterozygous females develop only mild RTT. Here, we create an improved female mouse model by introducing a mutation in Tsix

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Geissmann, Frederic, Yves Lepelletier, Sylvie Fraitag, et al. "Differentiation of Langerhans cells in Langerhans cell histiocytosis." Blood 97, no. 5 (2001): 1241–48. http://dx.doi.org/10.1182/blood.v97.5.1241.

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Langerhans cell histiocytosis (LCH) consists of lesions composed of cells with a dendritic Langerhans cell (LC) phenotype. The clinical course of LCH ranges from spontaneous resolution to a chronic and sometimes lethal disease. We studied 25 patients with various clinical forms of the disease. In bone and chronic lesions, LCH cells had immature phenotype and function. They coexpressed LC antigens CD1a and Langerin together with monocyte antigens CD68 and CD14. Class II antigens were intracellular and LCH cells almost never expressed CD83 or CD86 or dendritic cell (DC)–Lamp, despite their CD40

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Aiuti, Alessandro, and Maria Grazia Roncarolo. "Ten years of gene therapy for primary immune deficiencies." Hematology 2009, no. 1 (2009): 682–89. http://dx.doi.org/10.1182/asheducation-2009.1.682.

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Abstract Gene therapy with hematopoietic stem cells (HSC) is an attractive therapeutic strategy for several forms of primary immunodeficiencies. Current approaches are based on ex vivo gene transfer of the therapeutic gene into autologous HSC by vector-mediated gene transfer. In the past decade, substantial progress has been achieved in the treatment of severe combined immundeficiencies (SCID)-X1, adenosine deaminase (ADA)-deficient SCID, and chronic granulomatous disease (CGD). Results of the SCID gene therapy trials have shown long-term restoration of immune competence and clinical benefit i

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Wee, Yinshen, Amanda N. Moore, Shihai Jia, Jing Zhou, John S. Colombo, and Rena N. D’Souza. "A Single-Step Self-Assembly Approach for the Fabrication of Aligned and Multilayered Three-Dimensional Tissue Constructs Using Multidomain Peptide Hydrogel." SLAS TECHNOLOGY: Translating Life Sciences Innovation 24, no. 1 (2018): 55–65. http://dx.doi.org/10.1177/2472630318777759.

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Hydrogels are homogenous materials that are limited in their ability to form oriented multilayered architecture in three-dimensional (3D) tissue constructs. Current techniques have led to advancements in this area. Such techniques often require extra devices and/or involve complex processes that are inaccessible to many laboratories. Here is described a one-step methodology that permits reliable alignment of cells into multiple layers using a self-assembling multidomain peptide (MDP) hydrogels. We characterized the structural features, viability, and molecular properties of dental pulp cells f

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Redondo, Natalia, Arthur L. Cantos, Jose Luis Graña, Marina J. Muñoz-Rivas, and K. Daniel O’Leary. "Treatment-Induced Changes in Undercontrolled and Overcontrolled Anger Subtypes of Perpetrators of Intimate Partner Violence and 5-Year Recidivism." Criminal Justice and Behavior 46, no. 12 (2019): 1700–1718. http://dx.doi.org/10.1177/0093854819879201.

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This study examines different types of partner-violent males based on anger profiles. A cluster analysis of 483 self-reports completed by partner-violent men using the State-Trait Anger Expression Inventory (STAXI-2) identified two clusters of Undercontrolled and Overcontrolled anger profiles. The Undercontrolled men presented with higher pre-intervention scores than Overcontrolled men on Borderline Personality Organization, psychopathic traits, impulsiveness, physical aggression, verbal aggression, alcohol use, and partner-abusive behavior. Following completion of a cognitive-behavioral thera

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Yao, Juo-Chin, Terrence Neal Wong, Maria Trissal, et al. "MIR142 Loss-of-Function Mutations Promote Leukemogenesis through Derepression of ASH1L Resulting in Increased HOX Gene Expression." Blood 128, no. 22 (2016): 2718. http://dx.doi.org/10.1182/blood.v128.22.2718.2718.

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Abstract Mutations of MIR142 have been identified in approximately 2% of de novo AML and in 20% of diffuse large B cell lymphoma (DLBCL). In AML, all of the mutations in MIR142 localize to the seed sequence of miRNA-142-3p, which is crucial in determining its target specificity. Previously, we showed that these mutations disrupt both miRNA-142-3p and miRNA-142-5p function, suggesting that loss of MIR142 plays a role in leukemic transformation (Yao et al, ASH abstract 1254, 2015). To test this hypothesis, we first characterized hematopoiesis in Mir142-/-mice. We previously reported that loss of

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Abdelaziz, Hamdy A. "From Content Engagement to Cognitive Engagement." International Journal of Technology Diffusion 4, no. 1 (2013): 16–32. http://dx.doi.org/10.4018/jtd.2013010102.

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The objective of this paper was to develop an immersive Web-based learning model and measure its effectiveness on improving self-questioning and self-study skills among graduate students. The proposed model was guided theoretically by the flipped classroom as a new Web-based learning trend. It was also guided pedagogically by active and reflective learning principles that support transforming the teaching and learning practices from content engagement to cognitive engagement. The targeted immersive learning model encompasses four reciprocal phases: Pro-act, Act, Reflect, and Re-act (PARR). A c

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Finlay, Barbara L. "The neuroscience of vision and pain: evolution of two disciplines." Philosophical Transactions of the Royal Society B: Biological Sciences 374, no. 1785 (2019): 20190292. http://dx.doi.org/10.1098/rstb.2019.0292.

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Research in the neuroscience of pain perception and visual perception has taken contrasting paths. The contextual and the social aspects of pain judgements predisposed pain researchers to develop computational and functional accounts early, while vision researchers tended to simple localizationist or descriptive approaches first. Evolutionary thought was applied to distinct domains, such as game-theoretic approaches to cheater detection in pain research, versus vision scientists' studies of comparative visual ecologies. Both fields now contemplate current motor or decision-based accounts of pe

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Bakhshinyan, David, Thusyanth Vijayakumar, Chitra Venugopal, et al. "54 Genes preserving stem cell state in Group 3 MB BTICs contribute to therapy evasion and relapse." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45, S3 (2018): S13. http://dx.doi.org/10.1017/cjn.2018.296.

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Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Current clinical trials for recurrent MB patients based on genomic profiles of primary, treatment-naïve tumors, provide limited clinical benefit since recurrent metastatic MBs are highly genetically divergent from their primary tumors. By adapting the existing Children’s Oncology Group treatment protocol for children with newly diagnosed high-risk MB for treatment of mice intracranially engrafted with human MB cells, we have characterized the rare treatment-refractory cell population in Group 3 MBs. MB cell populations re

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Farivar, Marziyeh, and Mahboobeh Mirzadeh Nodeh. "Disillusionment of Althusserism and Rebellious Individualism." International Journal of Linguistics, Literature and Translation 3, no. 5 (2020): 87–92. http://dx.doi.org/10.32996/ijllt.2020.3.5.10.

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This paper is a comparative study of two dramatic works of Henrik Ibsen’s “An Enemy of the people”, written in 1882, and Akbar Radi’s “The Savior in the Damp Morning” written in1986. It is an attempt at elaborating Althusser’s clarification of the term ‘Ideology’ as the disillusionment when the individualistic features are considered. This refers to the opposition which exists between how the ideological discourse functions and what an individual member of a society intents to establish. Rebelliousness is one of the significantly controversial characteristics of individualism which is regarded

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Franzke, Anke, Dietrich Peest, Michael Probst-Kepper, et al. "Autoimmunity Resulting From Cytokine Treatment Predicts Long-Term Survival in Patients With Metastatic Renal Cell Cancer." Journal of Clinical Oncology 17, no. 2 (1999): 529. http://dx.doi.org/10.1200/jco.1999.17.2.529.

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PURPOSE: In patients undergoing cytokine therapy, systemically applied interleukin-2 (IL-2) and/or interferon-alpha (IFN-α) have been reported to induce thyroid dysfunction as well as thyroid autoantibodies. We analyzed the correlation of thyroid autoimmunity with HLA phenotype, various other autoimmune parameters, and patient survival. PATIENTS AND METHODS: For this purpose, antithyroglobulin autoantibodies, antimicrosomal thyroid autoantibodies, thyroglobulin receptor autoantibodies, thyroid dysfunction, and multiple clinical parameters were determined in 329 unselected patients with metasta

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Goldman-Ida, Batsheva. "Jonathan Leaman: In Conversation." IMAGES 13, no. 1 (2020): 47–73. http://dx.doi.org/10.1163/18718000-12340130.

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Abstract Jonathan Leaman (b. 1954, London) is a British painter who is represented in the Tate Collection. This article, the result of 15 years of his correspondence with art historian and museum curator Batsheva Goldman-Ida, focuses on a group of works by the artist from the last two decades. Leaman’s familiarity with major Kabbalah scholarship, combined with his wide knowledge of poetry and philosophy, enable him to engage in concepts related to Kabbalah and art in a discursive manner that is unparalleled in modern scholarship. This article showcases Leaman’s remarks with source material for

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Mandler, Peter. "EDUCATING THE NATION: IV. SUBJECT CHOICE." Transactions of the Royal Historical Society 27 (November 1, 2017): 1–27. http://dx.doi.org/10.1017/s0080440117000020.

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ABSTRACTThis address tracks the choices made by students at English schools (O-Level, GCSE and A-Level) and at British universities (undergraduate degree) of what subjects to study over the whole of the period since the Second World War. There are marked long-term trends towards a greater diversity in subjects studied, especially at A-Level and degree level, and this tended to reduce over time the dominance of science, to the advantage of a range of subjects including social studies, traditional humanities and latterly creative arts. These trends reflect (most of all) the growing size and dive

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Moreau, C. Page, Emanuela Prandelli, Martin Schreier, and Silke Hieke. "Customization in Luxury Brands: Can Valentino Get Personal?" Journal of Marketing Research 57, no. 5 (2020): 937–47. http://dx.doi.org/10.1177/0022243720943191.

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Luxury brands have started to offer consumers the opportunity to customize their exclusive products by making certain aesthetic decisions, such as the color, fabric, or cut of their products. A robust finding in the marketing literature is that consumers place a greater value on customized than on standard products because these unique products better fit and communicate their tastes, preferences, and identity. However, the majority of focal products in these studies fall outside the luxury segment. The authors demonstrate that consumers’ customization preferences differ between mainstream and

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Torrez Dulgeroff, Laughing Bear, Miranda S. Oakley, Michal C. Tal, et al. "CD47 blockade reduces the pathologic features of experimental cerebral malaria and promotes survival of hosts withPlasmodiuminfection." Proceedings of the National Academy of Sciences 118, no. 11 (2021): e1907653118. http://dx.doi.org/10.1073/pnas.1907653118.

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CD47 is an antiphagocytic “don’t eat me” signal that inhibits programmed cell removal of self. As red blood cells (RBCs) age they lose CD47 expression and become susceptible to programmed cell removal by macrophages. CD47−/−mice infected withPlasmodium yoelii, which exhibits an age-based preference for young RBCs, were previously demonstrated to be highly resistant to malaria infection. Our study sought to test the therapeutic benefit of CD47 blockade on ameliorating the clinical syndromes of experimental cerebral malaria (ECM), using thePlasmodium bergheiANKA (Pb-A) murine model. In vitro we

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Man, Na, Yurong Tan, Fan Liu, et al. "Caspase-3 Can Promote Acute Myeloid Leukemia Development By Regulation of Autophagy." Blood 128, no. 22 (2016): 2714. http://dx.doi.org/10.1182/blood.v128.22.2714.2714.

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Abstract Background AML1-ETO (AE), a oncogenic protein generated by the t(8;21) translocation, causes acute myeloid leukemia (AML) in collaboration with other secondary events. The leukemogenicity of AE has been evaluated in multiple mouse models, such as expression of AE in Cdkn1a-null Hematopoietic stem cell (HSCs) and expression of AML1- ETO9a (AE9a), an alternatively spliced variant of AE, in WT HSCs. Both lead to the development of fully penetrant AML. Caspase-3 plays multiple roles in hematopoietic development and leukemia progression and treatment by affecting proliferation, self-renewa

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Bloomer, Melissa J., Alison M. Hutchinson, Laura Brooks, and Mari Botti. "Dying persons’ perspectives on, or experiences of, participating in research: An integrative review." Palliative Medicine 32, no. 4 (2017): 851–60. http://dx.doi.org/10.1177/0269216317744503.

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Background: Conducting research with dying persons can be controversial and challenging due to concerns for the vulnerability of the dying and the potential burden on those who participate with the possibility of little benefit. Aim: To conduct an integrative review to answer the question ‘What are dying persons’ perspectives or experiences of participating in research? Design: A structured integrative review of the empirical literature was undertaken. Data sources: Cumulative Index Nursing and Allied Health Complete, PsycINFO, MEDLINE, Informit and Embase databases were searched for the empir

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Green, Alexander A. "Synthetic bionanotechnology: synthetic biology finds a toehold in nanotechnology." Emerging Topics in Life Sciences 3, no. 5 (2019): 507–16. http://dx.doi.org/10.1042/etls20190100.

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Enabled by its central role in the molecular networks that govern cell function, RNA has been widely used for constructing components used in biological circuits for synthetic biology. Nucleic acid nanotechnology, which exploits predictable nucleic acid interactions to implement programmable molecular systems, has seen remarkable advances in in vitro nanoscale self-assembly and molecular computation, enabling the production of complex nanostructures and DNA-based neural networks. Living cells genetically engineered to execute nucleic acid nanotechnology programs thus have outstanding potential

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Harris, Bryan, Shawn Fahl, Jaqueline Perrigoue, Stephen M. Sykes, Amit Verma, and David L. Wiest. "Ribosomal Protein L22 Loss Predisposes Stem Cells to Transformation By Altering Metabolism." Blood 128, no. 22 (2016): 2733. http://dx.doi.org/10.1182/blood.v128.22.2733.2733.

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Abstract While mutations in ribosomal proteins (RP) have long been associated with increased cancer risk, the molecular basis for this association remains unclear. The prevailing view is that mutations in RP increase cancer risk either by impairing the biogenesis or function of the ribosome. Here, we report that loss of the RP, Rpl22, is frequently observed in human myelodysplastic syndrome (MDS) and is associated with reduced survival in acute myelogenous leukemia (AML). The link between Rpl22 loss and aggressiveness of myeloid disease is causal, since it is replicated in mice lacking Rpl22.

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Chuapetcharasopon, Pylin, Lukas Neville, Wendi L. Adair, Susan E. Brodt, Terri R. Lituchy, and Aimy A. Racine. "Cultural mosaic beliefs as a new measure of the psychological climate for diversity." International Journal of Cross Cultural Management 18, no. 1 (2017): 7–32. http://dx.doi.org/10.1177/1470595817745898.

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This article introduces the concept of cultural mosaic beliefs (CMBs) as a component of effective multicultural work groups. Building on theories of group diversity and self-verification, and responding to calls to understand moderators that explain the impact of group diversity on performance outcomes, we conceptualize CMBs as a psychological climate that individual group members perceive to promote the recognition, acceptance and expression, and utilization of cultural diversity (values, traditions, and practices) in their work. We also propose that CMBs might attenuate conflict that can som

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Dev, Rony, Akhila Sunkepally Reddy, Joseph Anthony Arthur, et al. "Adaptive and maladaptive coping strategies among patients with advanced cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): e24129-e24129. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e24129.

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e24129 Background: Few studies have examined the coping mechanisms among patients with advanced cancer seen by palliative care. The objective of the study was to evaluate coping strategies in advanced cancer patients and identity risk factors for maladaptive coping. Methods: The authors conducted a secondary analysis of a cross-sectional survey on chemical coping. We prospectively enrolled patients with advanced cancer from a Supportive Care Clinic and documented the patient demographics, symptom expression (Edmonton Symptom Assessment System), Zubrod performance status, substance use history

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