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Dissertations / Theses on the topic 'Self-Microemulsifying Drug Delivery System'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Challis, Deborah. "Physicochemical and biopharmaceutical studies of novel self-emulsifying systems for administration by the oral route (SEDDS)." Thesis, University of Bath, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280871.

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2

Whitmire, Rachel Elisabeth. "Self-assembling polymeric nanoparticles for enhanced intra-articular anti-inflammatory protein delivery." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/43587.

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The goal of this thesis was to develop a new drug-delivering material to deliver anti-inflammatory protein for treating OA. Our central hypothesis for this work is that a controlled release/presentation system will more effectively deliver anti-inflammatory protein therapies to the OA joint. The primary goal of this work was to synthesize a block copolymer that could self-assemble into injectable, sub-micron-scale particles and would allow an anti-inflammatory protein, IL-1ra, to be tethered to its surface for efficient protein delivery. The block copolymer incorporated an oligo-ethylene mono

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3

Uesaka, Akihiro. "Precise Structural and Functional Control of Molecular Assemblies Composed of Amphiphilic Peptides Having a Hydrophobic Helical Block." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199273.

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4

Miranda, Beatriz Nogueira Messias de. "Mucus-penetrating polymersomes as a potential lung drug delivery system: preparation, in vitro characterization, and biodistribution tests." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-14032019-095025/.

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O muco protege o corpo humano de partículas externas, mas também representa uma barreira para a entrega de controlada de medicamentos através de nanocarregadores. Para ultrapassar a barreira do muco e impedir mucoadesão, nanopartículas sólidas são normalmente revestidas com polímeros inertes, tais como o polietileno glicol (PEG). No entanto, trata-se de um procedimento relativamente complexa. Nesta tese, estudamos métodos para fabricar nanocarreadores com uma excepcional combinação de propriedades, incluindo uma boa capacidade de mucopenetração e uma grande capacidade de carga. Ao contrário do

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5

Zhao, Tianjing. "Self-nanoemulsifying drug delivery systems (SNEDDS) for the oral delivery of lipophilic drugs." Doctoral thesis, University of Trento, 2015. http://eprints-phd.biblio.unitn.it/1608/1/Doctoral_thesis-Self-nanoemulsifying_drug_delivery_systems_(SNEDDS)_for_the_oral_delivery_of_lipophilic_drugs-Tianjing_ZHAO.pdf.

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The increasing number of lipophilic drug candidates in development in the pharmaceutical industry calls for advanced drug delivery systems with increased bioavailability less day-to-day and food-intake-dependent. Many of these drug candidates possess poor water solubility, so that their dissolution rate in the gastrointestinal tract (GIT) limits their absorption following oral administration. In the past few decades, various lipid-based formulations have been investigated to enhance the bioavailability of such challenging drug candidates and to increase their clinical efficacy when administer

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6

Zhao, Tianjing. "Self-nanoemulsifying drug delivery systems (SNEDDS) for the oral delivery of lipophilic drugs." Doctoral thesis, Università degli studi di Trento, 2015. https://hdl.handle.net/11572/369035.

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The increasing number of lipophilic drug candidates in development in the pharmaceutical industry calls for advanced drug delivery systems with increased bioavailability less day-to-day and food-intake-dependent. Many of these drug candidates possess poor water solubility, so that their dissolution rate in the gastrointestinal tract (GIT) limits their absorption following oral administration. In the past few decades, various lipid-based formulations have been investigated to enhance the bioavailability of such challenging drug candidates and to increase their clinical efficacy when administere

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7

Fatnassi, Mohamed. "Microsphères nano-structurées obtenues par atomisation-séchage : synthèses, caractérisation, encapsulation et libération de principes actifs." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20243/document.

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L'objectif de cette thèse consiste à développer une approche globale couplant les procédés sol-gel, les propriétés d'auto-assemblage des tensioactifs et l'atomisation séchage afin d'encapsuler directement des principes actifs dans des microsphères nanostructurées. Nous nous attachons en particulier à étudier les variations de la localisation et l'état physique des principes actifs en fonction des paramètres de synthèse. Le but de ce travail est également de mettre en relation les propriétés de libération avec la texture et la composition des microsphères. En parallèle, cette thèse a aussi pour

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8

Wang, Han. "Developing Novel Drug Delivery Systems For Platinum-based Anticancer Drugs Using Coordination-driven Self-assembly." Kent State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent1595260147978142.

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9

Michaelsen, Maria Høtoft. "The effect of digestion and drug load on absorption of poorly water soluble drugs from self-nanoemulsifying drug delivery systems (SNEDDS)." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59178.

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10

Aldosari, Basmah Nasser Abdullah. "Development and evaluation of self-nanoemulsifying drug delivery systems for oral delivery of indomethacin." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10044225/.

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In this study, indomethacin-loaded self-nanoemulsifying drug delivery systems (SNEDDS) were developed in liquid, solid and carrier-mediated formulations in order to improve the solubility of this model poorly water soluble drug. Liquid SNEDDS based on CapryolTM 90 (oil phase), Cremophor® RH 40 (surfactant) and Transcutol® HP (co-surfactant) were thermodynamically stable and produced clear nanoemulsions upon dilution. Optimized liquid formulations were transformed into solid SNEDDS by adsorption onto the inert carriers Syloid® XDP 3150, Neusilin® US2 and Florite® PS-200. Ratios of adsorbent: li

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11

Wakerly, M. G. "Self-emulsifying drug delivery systems based on nonionic surfactant-oil mixtures." Thesis, University of Bath, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235402.

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12

Wood, Kris Cameron. "Nanostructured gene and drug delivery systems based on molecular self-assembly." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39350.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2007.<br>Includes bibliographical references.<br>Molecular self-assembly describes the assembly of molecular components into complex, supramolecular structures governed by weak, non-covalent interactions. In recent years, molecular self-assembly has been used extensively as a means of creating materials and devices with well-controlled, nanometer-scale architectural features. In this thesis, molecular self-assembly is used as a tool for the fabrication of both gene and drug delivery systems which, by virtue

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13

Patel, Manisha Jagdishchandra. "The formulation and characterisation of polyglycolysed glyceride self-emulsifying drug delivery systems." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326220.

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14

Tison, Christopher Kirby. "Programmable, isothermal disassembly of DNA-linked colloidal particles." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/28189.

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Thesis (M. S.)--Materials Science and Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Milam, Valeria; Committee Member: Boyan, Barbara; Committee Member: Li, Mo; Committee Member: McDevitt, Todd; Committee Member: Sandhage, Ken.

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15

Nguyen, Duong Thuy. "Self-assembly Polymeric Nanoparticles Composed of Polymers Crosslinked with Transition Metals for Use in Drug Delivery." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc822738/.

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A major drawback of chemotherapy is the lack of selectively leading to damage in healthy tissue, which results in severe acute side effects to cancer patients. The use of nanoparticles as a drug delivery system has emerged as novel strategy to overcome the barriers of immunogenic response, controlled release of therapeutic, and targeting the toxicity only to cancerous cells. In this study, polymeric nanoparticles composed of transition metals and particles derived from natural biopolymers have been generated via self-assembly. For example, nanoparticles composed of cobalt crosslinked with a

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16

Kwok, Connie Sau-Kuen. "Development of self-assembled molecular structures on polymeric surfaces and their applications as ultrasonically responsive barrier coatings for on-demand, pulsatile drug delivery /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/7999.

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17

Serpe, Michael Joseph. "Self-Assembly of Poly(N-isopropylacrylamide) Microgel Thin Films." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/4806.

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The assembly of poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAm-co-AAc) microgel thin films into disordered and ordered arrays was investigated. Disordered pNIPAm-co-AAc microgel arrays were assembled based on electrostatic attractions between polyanionic pNIPAm-co-AAc microgels and polycationic poly(allylamine hydrochloride) (PAH). These interactions were studied in solution and subsequently used to assemble thin films following a Layer-by-Layer assembly protocol. Thin films were assembled as a function of pNIPAm-co-AAc microgel solution temperature and the resultant film thermoresponsivi

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18

Sharma, Vishnu Dutt. "INTERFACIAL ENGINEERING OF SYNTHETIC AMPHIPHILES AND ITS IMPACT IN THE DESIGN OF EFFICIENT GENE AND DRUG DELIVERY SYSTEMS." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/280244.

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Pharmaceutical Sciences<br>Ph.D.<br>Cancer is currently the second most common cause of death in the world. Despite tremendous progress in the treatment of different forms of cancer, the five year survival rates for lung, colorectal, breast, prostate, pancreatic and ovarian cancers remain quite low. New therapies are urgently needed for the better management of these diseases. In this context, both therapeutic gene and drug delivery constitute promising approaches for cancer treatment and are addressed in this thesis. Focusing on gene delivery, we are proposing the use new pyridinium amphiphil

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19

Satyal, Uttam. "Efficient Drug and Nucleic Acid Delivery Systems based on Synthetic Amphiphiles with Tuned Oil/Water Interfaces." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/531985.

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Pharmaceutical Sciences<br>Ph.D.<br>Today, drugs are an integral part of healthy human life, with new drug entities being introduced every year in clinic. The advancement of drug development brings complexity and variation, in terms of both physical and chemical properties. Some of these physicochemical characteristics are many times suboptimal, eventually requiring robust delivery systems that can precisely deliver the drugs to the desired tissues. Although many materials have been studied for the generation of drug delivery systems, there is always a need for biomaterials with better propert

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20

Mercuri, Annalisa. "A Physico-Chemocal Investigation into the Factors Affecting the Behaviour of Self-Emulsifying Drug Delivery Systems." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518385.

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The aim of this work was to investigate the relationship between drug-loading and self-emulsification. Several techniques were used to assess the physico-chemical properties of a self-emulsifying formulation formed by GRAS listed excipients with and without a model drug. The micropolarity at the droplet interface was found to be related to the HLB of the surfactant mixtures and it was shown to increase when the drug ibuprofen (6% w/w) was present. IH-NMR showed that this is due to the preferred solubilisation site of the drug; in fact, surfactant-like drugs preferably solubilise at the palisad

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21

Mudyahoto, Tsitsi. "Formulation, characterisation and optimisation of self-nanoemulsifying drug delivery systems (SNEDDS) loaded with artemether and lumefantrine." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/63503.

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22

Xi, Jia. "Modulation of oleanolic acid dissolution profile via solid state manipulation and self-nanoemulsifying drug delivery systems (SNEDDS)." Thesis, University of Macau, 2008. http://umaclib3.umac.mo/record=b2158690.

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23

Lin, Yu-bu, and 林于卜. "Preparation and Characterization of Curcumin Self-microemulsifying Drug Delivery System." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/tad45b.

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碩士<br>大同大學<br>生物工程學系(所)<br>107<br>Curcumin is an orange-yellow powder with pharmacological properties such as hypolipidemic, anti-oxidant, anti-inflammatory and anti-atherosclerotic arteriosclerosis. However, curcumin is a lipophilic polyphenolic substance that is extremely poorly soluble in water and easy to decompose under alkaline conditions. It will be quickly metabolized into inactive products and excreted in the body after entering the body. Therefore, curcumin, not be absorbed when it is ingested alone, greatly reduces the effect for human health. Self-microemulsifying drug delivery sys

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24

Su, Yu-De, and 蘇育德. "Study on Oral Absorption of Fenofibrate from Self-Microemulsifying Drug Delivery System." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/72245702839241654791.

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碩士<br>臺北醫學大學<br>藥學研究所<br>95<br>Self-microemulsifying drug delivery systems (SMEDDSs), which are self-emulsified into a clear and translucent fluid in aqueous medium under gentle digestive motility in the gastrointestinal tract, usually consisting of a mixture of oils, surfactant systems and drugs, represent a possible alternative to traditional oral formulations of poorly-water soluble. In the present study, a model lipophilic compound, Fenofibrate (an effective agent for the treatment of various types of dyslipidemia), was formulated in a medium chain triglyceride oil (MCT) and nonionic surfa

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25

Perera, Lynn, and 林貝拉. "Self-microemulsifying drug delivery system containing calebin-A enhanced treatment of colorectal cancer." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/yuf87f.

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碩士<br>國立臺灣大學<br>食品科技研究所<br>105<br>Colorectal cancer is the third most commonly diagnosed cancer and the third leading cause of cancer death worldwide. Recent studies have shown that calebin-A, a phytochemical from the rhizomes of turmeric (Curcuma longa), has anti-cancer, anti-inflammation, and anti-oxidation potential. However due to its hydrophobic property, the therapeutic potentials of calebin-A is greatly limited in the in vivo models by its poor solubility. There are various drug delivery systems that have been reported to be successful in delivering hydrophobic agents into an aqueous en

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26

Wang, Yun-Ting, and 王韻婷. "Formulation Development of Epirubicin and Curcumin with Self-microemulsifying Drug Delivery System and Its Cytotoxicity Evaluation." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/89835836652647827728.

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碩士<br>高雄醫學大學<br>藥學研究所<br>98<br>Epirubicin was the common drug used for antitumor therapy recently. It was a non-specific cell cycle antitumor drug, but the treatment outcome after intravesical therapy was not satisfied. Because of some parts of the drug were not transferred into cancer cell exactly, and the perfusion of drug irritated and limited the drug retention time inside bladder. The short retention time and poor drug permeability for bladder membrane limited anticancer treatment. Curcumin was a discussed and investigated widely ingredient of ginger, many reports had shown that Curcumi

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27

Huang, Wei-Yu, and 黃煒裕. "Formulation Development and Evaluation of Solidified Self-Microemulsifying Drug Delivery Systems Containing a Poorly Water-Soluble Drug." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/62344599846229298944.

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碩士<br>臺北醫學大學<br>藥學研究所<br>97<br>Self-microemulsifying drug delivery systems (SMEDDSs), which can be self-emulsified into a translucent and isotropic fluid in aqueous medium under gentle digestive motility in the gastrointestinal tract, usually consisting of a mixture of oils, surfactants, cosurfactants and drugs, represent a promising alternative to traditional formulations of poorly water-soluble Compounds. In the present study, a model lipophilic drug, Fenofibrate, is formulated in n-butyl L-lactate, polysorbates (Tween 20 and Tween 80) and a number of alcohols (ethanol, 1-propanol and PEG 60

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28

Hung, Ming-Tse, and 洪銘澤. "Clinical Translation Research of Oral Chemotherapy Effectively Enabled with Co-Oral Administration of Chemodrug-loaded Self-microemulsifying drug delivery system plus Gastroretentive Drug delivery system and Herbal P-glycoprotein and CYP450 Dual Function Inhibitor Cocktail." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/wk8444.

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29

Yen, Ching-Chi, and 顏清棋. "Development of resveratrol self nano-emulsifying drug delivery system and pharmacokinetic evaluation." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/10720861833141210254.

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碩士<br>高雄醫學大學<br>藥學系碩士班<br>104<br>Resveratrol, a naturally occurring polyphenol, has shown various promising bioactivities. Unfortunately, resveratrol is restricted in clinical application due to poor dissolution and absorption. The aims of the current study were to develop and evaluate a self-nanoemulsifying delivery systems (SNEDS) to improve the oral bioavailability of resveratrol. Moreover, a sensitive HPLC-electrochemical detection (HPLC-EC) method for determination of resveratrol in rat plasma was developed. The developed formulations have been characterized by its dispersibility, percent

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30

Chu, Jacquelene. "Linker-based Lecithin Oral Drug Delivery Systems." Thesis, 2012. http://hdl.handle.net/1807/33716.

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In this study, pharmaceutical-grade and food-grade linker-based lecithin self-emulsifying delivery systems (SEDS) were developed with a combination of lipophilic and hydrophilic linkers. These additives at suggested concentrations are safe for pharmaceutical and food applications. The ratio of surfactant lecithin and linkers in these systems was optimized to develop surfactant in oil preconcentrates. The preconcentrates containing different surfactant concentrations and oil were diluted with fed state simulated intestinal fluid to produce pseudo-ternary phase diagrams and to identify the formu

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31

Kwan, Lana. "Triple Fortification of Salt with Vitamin A, Self-emulsifying Drug Delivery System, Iron, and Iodine." Thesis, 2012. http://hdl.handle.net/1807/32478.

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Triple fortification of salt with vitamin A, iron, and iodine has been investigated in the past to reduce micronutrient deficiencies in the developing world. The objective is to develop integrated nutrient delivery technology by microencapsulating a self-emulsifying drug delivery system (SEDDS) made of surfactants and a bioactive compound, retinyl palmitate. The SEDDS is used to enhance absorption of the vitamin A through food systems and to achieve targeted release of the active ingredient. Encapsulating vitamin A was difficult when using the spray dryer and the enteric coating, Aquacoat®.

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32

Chiou, Chi-Wei, and 邱麒維. "Novel Nanoparticles Formed via Self-Assembly of Poly(ethylene glycol-b-sebacic anhydride) for controlled drug delivery system." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/60624061964070914360.

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碩士<br>國立清華大學<br>化學工程學系<br>95<br>A series of biodegradable poly (ester-anhydride), Poly(sebacic anhydride-co-ethylene glycol), was prepared by melt condensation for use in advanced drug delivery applications. Sebacic acid, a hydrophobic monomer, was copolymerized with PEG in order to produce water-insoluble polymers capable of providing continuous drug release kinetics following immersion in an aqueous environment. Poly ethylene glycol(PEG) can reduce particle clearance from bloodstream by macrophages and was a FDA approved polymer. In this paper, we changed various amounts of PEG (15~35% by ma

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33

Hung, De kai, and 洪德鎧. "Self-microemulsifying system for curcumin transdermal delivery." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/87528766734401192074.

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碩士<br>長庚大學<br>生化與生醫工程研究所<br>98<br>The lipophilic drug, curcumin, has low oral bioavailability because of its low solubility and poor stability. By using microemulsion via the transdermal route, a new delivery system was developed to improve curcumin’s delivery. Stratum corneum in skin is the main obstacle in transdermal drug delivery systems. To overcome the stratum corneum barrier, several physical and chemical means to increase the drug penetration have been studied. In this study, a variety of chemical enhancers were screened with the help of Plackett Burman design to evaluate their effects

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34

MONTIS, COSTANZA. "Nucleolipid Self Assemblies for the Confinement and Delivery of Nucleic Acids." Doctoral thesis, 2013. http://hdl.handle.net/2158/823282.

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In this study we report a full investigation on a DNA delivery system based on anionic liposomes of the nucleolipid POP-Ade (1-palmitoyl-2-oleoylphosphatidyl-adenosine). We studied first DNA complexation process Ca2+-mediated by the designed delivery system. Quartz Crystal Microbalance and Neutron Reflectometry data on POP-Ade Supported Lipid Bilayers, as well as Dynamic Light Scattering and Zeta Potential data on POP-Ade vesicles highlighted the presence of a specific molecular recognition interaction beetween POP-Ade adenosine polar headgroup and nucleic acids' nucleobases, contributing bo

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35

Bruggeman, Kiara Anaya Fay. "Novel Growth Factor Delivery Systems from Self-Assembling Peptide (SAP) Hydrogels." Phd thesis, 2016. http://hdl.handle.net/1885/117065.

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Growth factors are important signalling molecules in regenerative medicine and tissue engineering, but their inherent instability, lasting only minute to hours in vivo, presents an obstacle to sustained and controlled delivery. This is particularly difficult to achieve in the brain, where the blood brain barrier (BBB) prevents systemic delivery. For this reason, much research is currently directed at incorporating growth factors into supportive tissue engineering materials that mimic the natural extracellular matrix (ECM). In this case temporally control

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36

Mohite, Virendra Haik Yousef. "Self controlled magnetic hyperthermia." 2004. http://etd.lib.fsu.edu/theses/available/etd-11152004-184909.

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Thesis (M.S.)--Florida State University, 2004.<br>Advisor: Dr. Yousef S. Haik, Florida State University, College of Engineering, Dept. of Mechanical Engineering. Title and description from dissertation home page (Jan. 13, 2005). Includes bibliographical references.

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Rakkanka, Vipaporn. "A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet." Thesis, 2003. http://hdl.handle.net/1957/30894.

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Li, Tzu-Pin, and 黎子賓. "Development and Application of Lecithin-based Self-Assembly Mixed Micellar Drug Delivery Systems As Transmucosal Delivery Dosage Type Platform." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/875hb5.

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39

Wong, Wan-Ping, and 翁婉萍. "Development and characterization of lecithin-based self-assembly mixed micellar drug delivery systems and its applications on phytochemicals." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/s9x2gs.

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碩士<br>臺北醫學大學<br>生技製藥企業經營管理產業碩士專班<br>102<br>Phytochemicals have great potential for maintaining and promoting health, as well as preventing and potentially treating some diseases. However, the low solubility, stability, bioavailability and target specificity generally have limited clinical application. In this study, the solubility of four phytochemicals (Curcumin/Resveratrol/Honokiol-Magnolol) was in an attempt to be enhanced by encapsulating in self-assembly lecithin-based mixed micelles composed of lecithin and several amphiphilic material (TPGS/Pluronic®/Cremophor®/Sodium deoxycholate). Sel

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40

Yan, Liang. "Studies of self-assembled substituted poly(acrylate) networks as potential sustained drug delivery systems and of fluorescent conjugated polymer nanoparticles in cell imaging." Thesis, 2016. http://hdl.handle.net/2440/103611.

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Polymer networks are promising biomaterials for drug delivery as they have porous structures and are often biocompatible. The general aspects of the host-guest complexation capability of polymer networks containing cyclodextrins as well as their application in drug delivery are considered in Chapter 1. The introduction of cyclodextrins into polymer networks has the potential to improve drug loading capacity and modulate subsequent drug release behavior due to the host-guest complexation by cyclodextrins of drug molecules. Thus, Chapter 2 and Chapter 3 are concerned with new research on water s

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Umerska, A., Krzysztof J. Paluch, M. J. Santos-Martinez, C. Medina, O. I. Corrigan, and L. Tajber. "Chondroitin-based nanoplexes as peptide delivery systems-Investigations into the self-assembly process, solid-state and extended release characteristics." Thesis, 2015. http://hdl.handle.net/10454/9416.

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Yes<br>A new type of self-assembled polyelectrolyte complex nanocarrier composed of chondroitin (CHON) and protamine (PROT) was designed and the ability of the carriers to bind salmon calcitonin (sCT) was examined. The response of sCT-loaded CHON/PROT NPs to a change in the properties of the liquid medium, e.g. its pH, composition or ionic strength was studied and in vitro peptide release was assessed. The biocompatibility of the NPs was evaluated in Caco-2 cells. CHON/PROT NPs were successfully obtained with properties that were dependent on the concentration of the polyelectrolytes and their

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