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Journal articles on the topic 'Self-Microemulsifying Drug Delivery System'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Wang, Lingzhi, Wenrui Yan, Yurun Tian, Huanhuan Xue, Jiankai Tang, and Liwei Zhang. "Self-Microemulsifying Drug Delivery System of Phillygenin: Formulation Development, Characterization and Pharmacokinetic Evaluation." Pharmaceutics 12, no. 2 (2020): 130. http://dx.doi.org/10.3390/pharmaceutics12020130.

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Phillygenin, as an active ingredient of Forsythia suspensa, possesses a wide range of biological and pharmacological activity. However, its development and application are restricted due to its poor bioavailability and low solubility. Our work aimed to develop a self-microemulsifying drug delivery system to improve the oral bioavailability of phillygenin. The composition of the self-microemulsifying drug delivery system was preliminary screened by the pseudo-ternary phase diagram. Subsequently, the central composite design method was employed to optimize the prescription of the self-microemuls

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2

Wankhade, Vikrant P., Nivedita S. Kale, and K. K. Tapar. "Self Microemulsifying Nutraceutical and Drug Delivery Systems." International Journal of Pharmaceutical Sciences and Nanotechnology 7, no. 3 (2014): 2520–28. http://dx.doi.org/10.37285/ijpsn.2014.7.3.3.

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Many chemical entities and nutraceuticals are poor water soluble and show high lipophilicity. It’s difficult to formulate them into oral formulation because of its low aqueous solubility which ultimately affects bioavailability. To enhance the bioavailability of such drugs compounds, self microemulsifying drug delivery system is the reliable drug delivery system. In this system the drug is incorporated in the isotropic system and formulated as unit dosage form. Self microemulsifying drug delivery system is the novel emulsified system composed of anhydrous isotropic mixture of oils, surfactant,

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3

Aggarwal, Geeta, SasidharanLeelakumari Harikumar, Parul Jaiswal, and Kashmir Singh. "Development of self-microemulsifying drug delivery system and solid-self-microemulsifying drug delivery system of telmisartan." International Journal of Pharmaceutical Investigation 4, no. 4 (2014): 195. http://dx.doi.org/10.4103/2230-973x.143123.

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4

Meghana, Raykar, and Shinde Ramesh. "SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM: A LIPID BASED DRUG DELIVERY SYSTEM." INTERNATIONAL JOURNAL OF CURRENT RESEARCH AND INNOVATIONS IN PHARMA SCIENCES 1, no. 1 (2022): 16–21. https://doi.org/10.5281/zenodo.8017592.

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5

., Bhupinder Kaur, and Monika Sharma . "Self-Microemulsifying Drug Delivery System- A Recent Approach in Drug Delivery System." Journal of Current Pharma Research 8, no. 4 (2018): 2504–13. http://dx.doi.org/10.33786/jcpr.2018.v08i04.003.

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6

Deshmukh, Ashish, and Shirishkumar Kulkarni. "Solid self-microemulsifying drug delivery system of ritonavir." Drug Development and Industrial Pharmacy 40, no. 4 (2013): 477–87. http://dx.doi.org/10.3109/03639045.2013.768632.

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7

Josef, Elinor, and Havazelet Bianco-Peled. "Sponges carrying self-microemulsifying drug delivery systems." International Journal of Pharmaceutics 458, no. 1 (2013): 208–17. http://dx.doi.org/10.1016/j.ijpharm.2013.09.024.

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8

Choi, Sung-Up, Mi Jeong Kim, Sung Tae Kim, et al. "Development of Self-Microemulsifying Drug Delivery Systems of Poorly Water-Soluble Pazopanib for Improvement of Oral Absorption." Science of Advanced Materials 12, no. 1 (2020): 152–60. http://dx.doi.org/10.1166/sam.2020.3649.

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Self-microemulsifying drug delivery systems represent a stable formulation for enhancing the solubility and absorption efficacy of poorly soluble drugs. In this study, a self-microemulsifying drug delivery system (SMEDDS) was designed and applied for oral administration of poorly water-soluble pazopanib, a Biopharmaceutical Classification Class II anticancer drug. The solubility of pazopanib was first evaluated using various oils, surfactants, and co-surfactants. Pseudoternary phase diagrams were plotted to identify the selfemulsifying region and the phase behavior of optimized vehicle selecte

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9

Al-Tamimi, Duaa J., and Ahmed A. Hussien. "Formulation and Characterization of Self-Microemulsifying Drug Delivery System of Tacrolimus." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 30, no. 1 (2021): 91–100. http://dx.doi.org/10.31351/vol30iss1pp91-100.

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Abstract The present investigation aimed to formulate a liquid self-microemulsifying drug delivery system (SMEDDS) of tacrolimus to enhance its oral bioavailability by improving its dispersibility and dissolution rate. Four liquid SMEDDS were prepared using maisine CC as oil phase, labrasol ALF as surfactant and transcutol HP as co-surfactant based on the solubility studies of tacrolimus in these components. The phase behavior of the components and the area of microemulsion were evaluated using pseudoternary phase diagrams. The formulations were also assessed for thermodynamic stability,

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10

Zhang, Yuxia, Yan Bai, Huali Chen, Yuanrui Huang, Pei Yuan, and Liangke Zhang. "Preparation of a colon-specific sustained-release capsule with curcumin-loaded SMEDDS alginate beads." RSC Advances 7, no. 36 (2017): 22280–85. http://dx.doi.org/10.1039/c6ra27693h.

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11

Singh, Dilpreet, Ashok K. Tiwary, and Neena Bedi. "Self-microemulsifying Drug Delivery System for Problematic Molecules: An Update." Recent Patents on Nanotechnology 13, no. 2 (2019): 92–113. http://dx.doi.org/10.2174/1872210513666190619102521.

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Background: The poor bioavailability of a problematic molecule is predominantly due to its high lipophilicity, low solubility in gastric fluids and/or high fist pass metabolism. Self microemulsifying drug delivery system (SMEDDS), a lipidic type IV nano-formulation has been of interest in the field of pharmaceutical research due to its potential for tailoring the physicochemical properties of pharmaceutical molecules. Methods: This review provides insights on various recent innovations and reports from the past seven years (2012-2019) of self-emulsifying formulations for the delivery of variou

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12

Dokania, Shambhu, and Amita K. Joshi. "Self-microemulsifying drug delivery system (SMEDDS) – challenges and road ahead." Drug Delivery 22, no. 6 (2014): 675–90. http://dx.doi.org/10.3109/10717544.2014.896058.

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13

Wu, Xuemei, Jianhua Xu, Xiuwang Huang, and Caixia Wen. "Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability." Drug Development and Industrial Pharmacy 37, no. 1 (2010): 15–23. http://dx.doi.org/10.3109/03639045.2010.489560.

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14

Sakai, Kenichi, Hiroyuki Maeda, Takayuki Yoshimori, Kouki Obata, and Yutaka Ogawa. "High-throughput formulation screening system for self-microemulsifying drug delivery." Drug Development and Industrial Pharmacy 35, no. 6 (2009): 746–55. http://dx.doi.org/10.1080/03639040802555606.

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15

von Suesskind-Schwendi, Marietta, Michael Gruber, Didier Touraud, et al. "Pharmacokinetics of a self-microemulsifying drug delivery system of tacrolimus." Biomedicine & Pharmacotherapy 67, no. 6 (2013): 469–73. http://dx.doi.org/10.1016/j.biopha.2013.04.001.

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16

Wu, Wei, Yang Wang, and Li Que. "Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system." European Journal of Pharmaceutics and Biopharmaceutics 63, no. 3 (2006): 288–94. http://dx.doi.org/10.1016/j.ejpb.2005.12.005.

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17

Wei, Jyh-Ding, Hsiu-O. Ho, Chien-Ho Chen, Wen-Tin Ke, Eric Tsu-Hsin Chen, and Ming-Thau Sheu. "Characterisation of fenofibrate dissolution delivered by a self-microemulsifying drug-delivery system." Journal of Pharmacy and Pharmacology 62, no. 12 (2010): 1685–96. http://dx.doi.org/10.1111/j.2042-7158.2010.01182.x.

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18

Zhang, Na, Na Zhang, Dan Dan She, Lian Dong Hu, and Hong Fang Liu. "Preparation and Evaluation of Daidzein Loaded Self-Microemulsifying Drug Delivery System." Applied Mechanics and Materials 140 (November 2011): 200–205. http://dx.doi.org/10.4028/www.scientific.net/amm.140.200.

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The purpose of the current investigation was to improve the solubility of daidzein, a poorly water-soluble drug which exhibits low oral absorption bioavailability, in a self-micro-emulsifying drug delivery system that is suitable for oral administration. A carefully executed central composite design was applied to screen the optimal formulation of daidzein SMEDDS. The formulations were characterized by solubility of the drug in the vehicle, droplet size, and emulsification time. The optimal formulation consists of 20 % ethyl oleate, 64 % OP emulsifier, and 16 % polyethylene glycol 400. The dro

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19

Muhammed, Saja Abdulkareem, and Khalid Kadhem Al-Kinani. "Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system." F1000Research 12 (March 22, 2023): 315. http://dx.doi.org/10.12688/f1000research.130749.1.

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Background: The nonsteroidal anti-inflammatory medication meloxicam (MLX) belongs to the oxicam family and is used to reduce inflammation and pain. The aim of this study was to improve MLX's dispersibility and stability by producing it as a liquid self-microemulsifying drug delivery system since it is practically insoluble in water. Methods: Five different formulations were made by adjusting the amounts of propylene glycol, Transcutol P, Tween 80, and oleic acid oil and establishing a pseudo-ternary diagram in ratios of 1:1, 1:2, 1:3, 1:4, and 3:4, respectively. All of the prepared formulation

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20

Sharvani, K., D. Shripathy, and R. Shabaraya A. "Self-Microemulsifying Drug Delivery Systems: Formulation Design and Characterization." American Journal of PharmTech Research 12, no. 3 (2022): 134–51. https://doi.org/10.5281/zenodo.7106684.

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ABSTRACT Oral route has been considered as most convenient route but restricted to only hydrophilic compounds having GI stability and greater dissolution. The delivery of lipophilic compounds has been area of interest since most of the drugs under discovery shows limited bioavailability. Self-emulsifying delivery systems (SMEDDS) has drawn a greater attention in the formulation of poorly soluble compounds where increase in the absorption and permeation of the drug has observed. The self-emulsification which occurs in the case of SMEDDS has shown a potential advantage over conventional emulsion

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21

Prajapati, Anuradha P., Pratik S. Patel, Neha S. Vadgama, Sachin Narkhede, Shailesh Luhar, and Shivani J. Gandhi. "Formulation Development and Evaluation of Solid Self Microemulsifying Drug Delivery System of Azelnidipine." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 03 (2023): 237–49. http://dx.doi.org/10.25004/ijpsdr.2023.150303.

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This study aimed to develop a self-micro emulsifying drug delivery system (SMEDDS) for poorly soluble azelnidipine using Capryol 90 as the oil, Tween 80 as the surfactant, and transcutol-HP as the co-surfactant. A factorial design was used to optimize the formulation, and Neusilin UFL2 was used as an adsorbent to convert the liquid SMEDDS to solid SMEDDS. The optimized formulation had a particle size of 80.5nm, a transmittance of 98.2%, a zeta potential of -3.1 mV, and a polydispersibility index of 0.226. The solid SMEDDS tablet exhibited improved drug release (99.4% in 60 minutes) compared to

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22

Laddha, Pankaj, Vrunda Suthar, and Shital Butani. "Development and optimization of self microemulsifying drug delivery of domperidone." Brazilian Journal of Pharmaceutical Sciences 50, no. 1 (2014): 91–100. http://dx.doi.org/10.1590/s1984-82502011000100009.

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The present investigation is aimed to develop self-microemulsifying drug delivery system (SMEDDS) to improve the in vitro dissolution of a BCS (Biopharmaceutical Classification System) class II anti emetic agent, domperidone. Solubility study was performed to identify the ingredients showing highest solubility of domperidone. The ternary phase diagrams were plotted for selected components to identify the area of microemulsion existence. D-optimal mixture experimental design was applied to optimize a liquid SMEDDS using formulation variables; the oil phase X1 (Oleic acid), the surfactant X2 (La

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23

Patel, Pranav, Kush Trivedi, Tejal Mehta, and Shital Panchal. "Preparation and Evaluation of Self-microemulsifying Drug Delivery System of Sirolimus." Drug Delivery Letters 3, no. 3 (2013): 175–84. http://dx.doi.org/10.2174/22103031113039990002.

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24

Liu, Guo Qing, Hua Feng Zhou, Jing Zhang, et al. "Resveratrol Loaded Self-Microemulsifying Drug Delivery System (SMEDDS): Development and Optimization." Advanced Materials Research 936 (June 2014): 763–69. http://dx.doi.org/10.4028/www.scientific.net/amr.936.763.

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We developed a SMEDDS to enhance the oral delivery of resveratrol by using high performance liquid chromatography, a pseudo ternary phase diagram and a central composite design (CCD). We found that the optimal formulation of 12.69% greoil gtcc, 62.29% Cremophor EL, and 25.02% Labrasol. We characterized the particle size and zeta potential of the final SMEDDS.

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25

Cui, Shu-xia, Shu-fang Nie, Li Li, Chang-guang Wang, Wei-san Pan, and Jian-ping Sun. "Preparation and Evaluation of Self-Microemulsifying Drug Delivery System Containing Vinpocetine." Drug Development and Industrial Pharmacy 35, no. 5 (2009): 603–11. http://dx.doi.org/10.1080/03639040802488089.

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26

Singh, Ajeet K., Akash Chaurasiya, Manish Singh, Satish C. Upadhyay, Rama Mukherjee, and Roop K. Khar. "Exemestane Loaded Self-Microemulsifying Drug Delivery System (SMEDDS): Development and Optimization." AAPS PharmSciTech 9, no. 2 (2008): 628–34. http://dx.doi.org/10.1208/s12249-008-9080-6.

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27

Zhang, Ping, Ying Liu, Nianping Feng, and Jie Xu. "Preparation and evaluation of self-microemulsifying drug delivery system of oridonin." International Journal of Pharmaceutics 355, no. 1-2 (2008): 269–76. http://dx.doi.org/10.1016/j.ijpharm.2007.12.026.

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28

Hyma, P., and K. Abbulu. "Formulation and characterisation of self-microemulsifying drug delivery system of pioglitazone." Biomedicine & Preventive Nutrition 3, no. 4 (2013): 345–50. http://dx.doi.org/10.1016/j.bionut.2013.09.005.

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29

Shen, Qi, Xi Li, Dan Yuan, and Wei Jia. "Enhanced Oral Bioavailability of Daidzein by Self-Microemulsifying Drug Delivery System." CHEMICAL & PHARMACEUTICAL BULLETIN 58, no. 5 (2010): 639–43. http://dx.doi.org/10.1248/cpb.58.639.

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30

Liu, Wenli, Rui Tian, Wenjing Hu, et al. "Preparation and evaluation of self-microemulsifying drug delivery system of baicalein." Fitoterapia 83, no. 8 (2012): 1532–39. http://dx.doi.org/10.1016/j.fitote.2012.08.021.

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31

Arju, N., PK Bara, MT Amin, DR Bhowmik, and MS Hossain. "Self microemulsifying powder using Aerosil as a carrier." Bangladesh Journal of Scientific and Industrial Research 56, no. 2 (2021): 141–46. http://dx.doi.org/10.3329/bjsir.v56i2.54321.

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This investigation highlighted the development of a solid self micro emulsifying drug delivery system (solid SMEDDS) for improved oral delivery of Valsartan. Liquid SMEDDS were formulated and then the liquid formulation was transformed into free-flowing powder by adsorption on a solid carrier. Here the formulations were prepared in various ratios of the drug to the excipients. Various evaluation studies were performed. In-vitro release profiles of all formulations were evaluated. The concentration of the diffused drug was measured using a UV-visible spectrophotometer at λmax= 250 nm. The faste

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32

Shivaraj, Dinesh, Preethi Gopalpura Bellaiah Bellaiah, and Sudhakar Srinivasa. "Development and characterization of Olmesartan Medoximil Self-Microemulsifying Fast Disintegrating Tablet." Journal of Drug Delivery and Therapeutics 15, no. 4 (2025): 89–97. https://doi.org/10.22270/jddt.v15i4.7090.

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Olmesartan Medoxomil (OLM), is a BCS Class II hypertension drugs, with low solubility in water, leading to limited bioavailability. This study aimed to increase the dissolution rate of OLM using a Solid-Self Micro Emulsifying Drug Delivery System (S-SMEDDS). In the beginning, oils, surfactants, and co-surfactants were assessed for drugs solubility. Liquid SMEDDS was created by combining Capmul MCM (30-50%) as oil with Gelucire 44/14 and Transcutol HP (50-70%) as surfactants and co-surfactants. The method was tested for % transmittance, cloud point, reconstitution ability, stability, and drug c

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33

Thakkar, Hetal, Mayur Parmar, Jitesh Nangesh, and Divyakant Patel. "Formulation and characterization of lipid-based drug delivery system of raloxifene-microemulsion and self-microemulsifying drug delivery system." Journal of Pharmacy and Bioallied Sciences 3, no. 3 (2011): 442. http://dx.doi.org/10.4103/0975-7406.84463.

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34

Yi, Tao, and Jifen Zhang. "Effects of Hydrophilic Carriers on Structural Transitions and In Vitro Properties of Solid Self-Microemulsifying Drug Delivery Systems." Pharmaceutics 11, no. 6 (2019): 267. http://dx.doi.org/10.3390/pharmaceutics11060267.

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Self-microemulsifying drug delivery systems (SMEDDS) offer potential for improving the oral bioavailability of poorly water-soluble drugs. However, their susceptibilities during long term storage and in vivo precipitation issues limit their successful commercial application. To overcome these limitations, SMEDDS can be solidified with solid carriers, thus producing solid self-microemulsifying drug delivery systems (S-SMEDDS). In this study, effects of various hydrophilic carriers on structural transitions and in vitro properties of S-SMEDDS were investigated in order to set up in vitro methods

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35

Kim, Dong Shik, Jung Hyun Cho, Jong Hyuck Park, et al. "Self-microemulsifying drug delivery system (SMEDDS) for improved oral delivery and photostability of methotrexate." International Journal of Nanomedicine Volume 14 (July 2019): 4949–60. http://dx.doi.org/10.2147/ijn.s211014.

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36

Patil, Purushottam, Malik Shaikh, and Paresh Mahaparale. "DEVELOPMENT AND EVALUATION OF ZIPRASIDONE LOADED SOLID SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEM." INDIAN DRUGS 57, no. 08 (2020): 53–60. http://dx.doi.org/10.53879/id.57.08.12632.

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Solid self-micro emulsification technique is the new approach for poorly water-soluble and poorly bioavailable drugs by allowing the drug substance to be incorporated into the oil phase and thus having the ability to permeate the GI membrane to a faster extent. Oleic acid, Tween 80, methanol and colloidal silicon dioxide were used as penetrant, surfactant, co-surfactant and adsorbent, respectively. The interaction between drug and excipients was examined by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The results of DSC and FTIR studies did not re

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37

Quan, Guilan, Boyi Niu, Vikramjeet Singh, et al. "Supersaturable solid self-microemulsifying drug delivery system: precipitation inhibition and bioavailability enhancement." International Journal of Nanomedicine Volume 12 (December 2017): 8801–11. http://dx.doi.org/10.2147/ijn.s149717.

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38

Singh, Sandeep Kumar, Priya Ranjan Prasad Verma, and Balkishen Razdan. "Development and characterization of a lovastatin-loaded self-microemulsifying drug delivery system." Pharmaceutical Development and Technology 15, no. 5 (2009): 469–83. http://dx.doi.org/10.3109/10837450903286537.

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39

Zhao, Lili, Lin Zhang, Lin Meng, Jing Wang, and Guangxi Zhai. "Design and evaluation of a self-microemulsifying drug delivery system for apigenin." Drug Development and Industrial Pharmacy 39, no. 5 (2012): 662–69. http://dx.doi.org/10.3109/03639045.2012.687378.

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40

Madan, JyotsanaR, Bandavane Sudarshan, VinodS Kadam, and Dua Kamal. "Formulation and development of self-microemulsifying drug delivery system of pioglitazone hydrochloride." Asian Journal of Pharmaceutics 8, no. 1 (2014): 27. http://dx.doi.org/10.4103/0973-8398.134097.

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41

Hong, Eon-Pyo, Ju-Young Kim, Su-Hyeon Kim, et al. "Formulation and Evaluation of a Self-microemulsifying Drug Delivery System Containing Bortezomib." Chemical and Pharmaceutical Bulletin 64, no. 8 (2016): 1108–17. http://dx.doi.org/10.1248/cpb.c16-00035.

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42

Park, Sun Young, Chang Hwa Jin, Yoon Tae Goo, et al. "Supersaturable self-microemulsifying drug delivery system enhances dissolution and bioavailability of telmisartan." Pharmaceutical Development and Technology 26, no. 1 (2020): 60–68. http://dx.doi.org/10.1080/10837450.2020.1834580.

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43

Borhade, Vivek, Hema Nair, and Darshana Hegde. "Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus." AAPS PharmSciTech 9, no. 1 (2008): 13–21. http://dx.doi.org/10.1208/s12249-007-9014-8.

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44

Singh, Ajeet K., Akash Chaurasiya, Anshumali Awasthi, et al. "Oral Bioavailability Enhancement of Exemestane from Self-Microemulsifying Drug Delivery System (SMEDDS)." AAPS PharmSciTech 10, no. 3 (2009): 906–16. http://dx.doi.org/10.1208/s12249-009-9281-7.

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45

Li, Xinru, Quan Yuan, Yanqing Huang, Yanxia Zhou, and Yan Liu. "Development of Silymarin Self-Microemulsifying Drug Delivery System with Enhanced Oral Bioavailability." AAPS PharmSciTech 11, no. 2 (2010): 672–78. http://dx.doi.org/10.1208/s12249-010-9432-x.

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46

Tao, Chun, Yue Yu, Zhenzhen Chen, et al. "Effect of mesopores on solidification of sirolimus self-microemulsifying drug delivery system." Chinese Chemical Letters 29, no. 12 (2018): 1849–52. http://dx.doi.org/10.1016/j.cclet.2018.11.022.

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47

Hsieh, Chien-Ming, Ting-Lun Yang, Athika Darumas Putri, and Chin-Tin Chen. "Application of Design of Experiments in the Development of Self-Microemulsifying Drug Delivery Systems." Pharmaceuticals 16, no. 2 (2023): 283. http://dx.doi.org/10.3390/ph16020283.

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Oral delivery has become the route of choice among all other types of drug administrations. However, typical chronic disease drugs are often poorly water-soluble, have low dissolution rates, and undergo first-pass metabolism, ultimately leading to low bioavailability and lack of efficacy. The lipid-based formulation offers tremendous benefits of using versatile excipients and has great compatibility with all types of dosage forms. Self-microemulsifying drug delivery system (SMEDDS) promotes drug self-emulsification in a combination of oil, surfactant, and co-surfactant, thereby facilitating be

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48

Saggar, Sachin, Ashutosh Upadhayay, and Manish Goswami. "DESIGN, PREPARATION, AND EVALUATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF BAMBUTEROL HYDROCHLORIDE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 12 (2018): 389. http://dx.doi.org/10.22159/ajpcr.2018.v11i12.27890.

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Objective: The self-micro-emulsifying drug delivery system (SMEDDS) of bambuterol hydrochloride was designed, prepared, and evaluated to overcome the problem of poor bioavailability.Methods: The designing of the formulation included the selection of oil phase, surfactant, and cosolvent/cosurfactant based on the saturated solubility studies. Psuedoternary phase diagram was constructed using aqueous titration method, to identify the self-emulsifying region. Different ratios of the selected surfactant and cosolvent/cosurfactant (Smix) were also studied and used to construct the ternary phase diag

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49

Prajapati, Shailesh T., Harsh A. Joshi, and Chhaganbhai N. Patel. "Preparation and Characterization of Self-Microemulsifying Drug Delivery System of Olmesartan Medoxomil for Bioavailability Improvement." Journal of Pharmaceutics 2013 (September 24, 2013): 1–9. http://dx.doi.org/10.1155/2013/728425.

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Olmesartan medoxomil (OLM) is an angiotensin II receptor blocker (ARB) antihypertensive agent administered orally that has absolute bioavailability of only 26% due to the poor aqueous solubility (7.75 μg/ml). The aim of the present investigation was to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the oral absorption of OLM. The solubility of OLM in various oils, surfactants, and cosurfactants was determined. Pseudoternary phase diagrams were constructed using Acrysol EL 135, Tween 80, Transcutol P, and distilled water to identify the efficient self-microemulsificati

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50

Akula, Samatha, Aravind Kumar Gurram, and Srinivas Reddy Devireddy. "Self-Microemulsifying Drug Delivery Systems: An Attractive Strategy for Enhanced Therapeutic Profile." International Scholarly Research Notices 2014 (December 8, 2014): 1–11. http://dx.doi.org/10.1155/2014/964051.

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Abstract:

Ease of administration and painless approach made oral route the most preferred. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption. Failure to attain intended therapeutic effect of the poor water soluble drugs by this route led to development of novel drug delivery systems which will fulfill therapeutic needs with minimum dose. Although many formulation approaches like solid dispersions, complexation, pH modification, and cocrystals exist, lipid based delivery systems finding increased appliance with the appare

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