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Relevant bibliographies by topics / Self-signalling / Dissertations / Theses

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Dissertations / Theses on the topic 'Self-signalling'

Author: Grafiati

Published: 10 September 2021

Last updated: 17 July 2025

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1

Wamaitha, Sissy E. "Extracellular signalling and stem cell self-renewal." Thesis, Open University, 2017. http://oro.open.ac.uk/50582/.

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In preimplantation mouse embryos, signalling and gene regulatory networks cooperate to determine lineage segregation, and modulating signalling in vitro allows for stem cell populations to be established from these lineages. Fibroblast growth factor (FGF) signalling triggers the differentiation of primitive endoderm (PrE) cells fated to contribute to the yolk sac, while cells unreceptive to FGF form the epiblast (Epi) that subsequently contributes to the embryo proper. In vitro, FGF signalling is required for preimplantation Epi-derived mouse ES cells to exit self-renewal. Conversely, in human

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2

Wagstaffe, Sarah Jayne. "Improving chronic wound healing with self signalling antibodies for specific bacterial detection." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508801.

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3

Wilkins, Katie Anne. "Investigating pollen signalling networks triggered by the self-incompatibility response in Papaver rhoeas." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4109/.

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Self-incompatibility (SI) is a genetic mechanism which prevents self-fertilisation via the recognition and rejection of ‘self’ pollen. In the self-incompatible species Papaver rhoeas L., rejection of incompatible pollen is achieved through interaction of the female and male S-determinants, PrsS and PrpS, respectively. This interaction results in a Ca\(^{2+}\)-dependent signalling cascade in the ‘self’ pollen, which mediates programmed cell death (PCD). To date, many downstream effects of SI signalling cascade have been identified, including actin depolymerization, the formation of actin foci,

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4

Einhorn, Mark David. "An evaluation of the efficiency of self-organising versus fixed traffic signalling paradigms." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20306.

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5

Tarafdar, Anuradha. "The role of canonical Wnt/GSK3ß/ß-catenin signalling in stem cell self-renewal and differentiation." Thesis, University of Ulster, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551569.

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Canonical Wnt signalling influences the 'sternness' of both embryonic stem (ES) cells and haemopoietic stem cells (RSC). In this study we investigated how modulation of the canonical Wnt pathway affected ES cell self-renewal and haemopoietic differentiation. We observed that Wnt activation suppressed differentiation whereas inhibiting Wnt signalling enhanced differentiation. Relative Quantification using TaqMan Pluripotency Array cards ™ indicated that genes correlating to 'sternness' such as AFP, Tert, Nanog, Zgp 42, Tcf were up-regulated along with characteristic mesodermal markers (Brachyur

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6

Poulter, Natalie Sarah. "Investigating the role of the cytoskeleton and signalling in the self-incompatibility response of Papaver rhoeas." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/322/.

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Many flowering plants are hermaphrodite, which poses the problem of self-fertilisation and the subsequent loss of genetic fitness in the offspring. To prevent this, plants have developed a genetically controlled mechanism called self-incompatibility (SI) which allows self (incompatible) pollen to be recognised and rejected before fertilisation can occur. The SI response of Papaver rhoeas (field poppy) has been extensively studied at the molecular and cellular level. Rejection of incompatible pollen occurs on the stigma surface when the pollen S-determinant PrpS, a transmembrane protein, intera

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7

Mnatsakanyan, Movsesyan Hayk. "ROLE OF IONS IN STEM CELLS SIGNALLING." Doctoral thesis, Universitat Politècnica de València, 2019. http://hdl.handle.net/10251/123063.

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[ES] Los procesos de comunicación celular permiten a las células desarrollar una acción coordinada durante la embriogénesis y asimilar de forma coherente las señales recibidas a través del entorno. Algunas de las moléculas señalizadoras más usadas en la clínica y la investigación son las citoquinas. Sin embargo, existe una tendencia creciente en el uso de otro tipo de moléculas, como los iones metálicos. Algunos iones como el calcio y el zinc actúan como segundos mensajeros intracelulares. Otros como el litio son capaces de inactivar proteínas quinasa alterando rutas de señalización. En el des

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8

Pezzato, Cristian. "Organization and signal regulation in complex chemical systems." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424768.

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Supramolecular chemistry is the chemistry of the non-covalent bond, i.e. all those chemical processes relying on non-covalent interactions between molecules. In the last decades, chemists have learned to exploit non-covalent interactions for the construction of sensors, catalysts and materials. In particular self-assembly, defined as the spontaneous organization of small molecules into a well-defined structure has emerged as the most attractive way to prepare highly complex molecular architectures of nanosized dimensions. In this Thesis, the self-assembly of small molecules on the surface of m

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9

Giudice, Vincent. "Étude structurale et fonctionnelle d'un nouvel ARN non codant, Asgard, contrôlant l'autorenouvellement des cellules souches embryonnaires." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10271/document.

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Chez la souris, le Leukemia Inhibitory Factor (LIF) joue un rôle clé dans le maintien des cellules souches embryonnaires (ES) à l’état pluripotent. Le LIF agit en activant le facteur de transcription STAT3 via les kinases Jak. Cette activation est nécessaire et suffisante au maintien des cellules ES en autorenouvellement en présence de sérum. Une étude du transcriptome de STAT3 réalisée au laboratoire a permis d’identifier plusieurs gènes cibles de ce facteur, parmi lesquels plusieurs gènes inconnus. L’un d’eux, le gène 1456160_at, est fortement exprimé dans les cellules ES de souris et son ex

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10

Wülfrath, Stefan. "Migration von Relaisschaltungen der Eisenbahnsicherungstechnik auf Programmierbare Schaltkreise." Master's thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127754.

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In der vorliegenden Arbeit werden eine sichere FPGA-Stellwerksplattform und ein Transformationsverfahren entwickelt, mit dem die Schaltungen bestehender Relaisstellwerke in eine FPGA-Logik überführt werden können. Die FPGA-Stellwerksplattform ersetzt die Innenanlage eines Relaisstellwerks. Ihre Schnittstellen entsprechen den bisherigen Schnittstellen am Kabelabschlussgestell und zur Bedien- und Meldeeinrichtung. Damit ist eine einfache Migration bestehender Stellwerke möglich. Das Sicherheitskonzept basiert auf einer zweikanaligen Struktur mit sicherem Vergleicher und zusätzlichen Selbsttests

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11

Zhen, Y. "Protocadherin 15 modulates oligodendrocyte progenitor cell proliferation and contact-mediated self-repulsion through two distinct signalling pathways." Thesis, 2020. https://eprints.utas.edu.au/35856/1/Zhen_whole_thesis.pdf.

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Oligodendrocyte progenitor cells (OPCs) comprise the largest proliferating cell population in the healthy, adult brain. Dysregulation of OPCs has been associated with the formation of pediatric and adult gliomas. The purpose of this research is to understand: how non-clustered protocadherins (Pcdhs) allow OPCs to maintain their even distribution throughout the central nervous system (CNS); whether nonclustered Pcdhs regulate OPC proliferation and the generation of new oligodendrocytes (OLs) throughout life, and whether the dysregulation of nonclustered Pcdh signalling can initiate glioma forma

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12

Moledina, Faisal. "A Microfluidic System for Mouse Embryonic Stem Cell Culture and Microenvironment Control." Thesis, 2011. http://hdl.handle.net/1807/29533.

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The embryonic stem cell (ESC) microenvironment contains various localized physical and biochemical cues to direct cell fate. Current approaches for microenvironmental regulation rely on restricting cell behaviour to control endogenous signals such as secreted ligands. This report presents a microfluidic device that can directly manipulate the removal of autoregulatory ligands from culture and control the activation of Signal Transducer and Activator of Transcription-3 (Stat3) in ESCs. Specifically, the response of Stat3 was measured under diffusive and convective mass transfer regimes. A Brown

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13

Ferreira, João Miguel Pimenta. "Osmium tetroxide in a dynamic supramolecular system." Master's thesis, 2018. http://hdl.handle.net/10773/25638.

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Supramolecular Chemistry plays an important role in attaining levels of com-plexity in chemical systems that would not be available otherwise, this includes design of complex chemical signalling networks. Here a report is made on the discovery of a host-guest complex of a catalyst—OsO4—in an Fe4L6 tetrahedral imine coordination cage which enables the regu-lation of its activity without covalent transformations. The remarkable stability of the assembly hosting this powerful oxidizer is studied as to its stability and dy-namics by NMR. Due to the sensitivity of the work, improvements were done o

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14

Rocha, Catarina Lucas Serrão André. "The effect of performance brands and group identification on consumers’ expected performance and psychological well-being." Master's thesis, 2018. http://hdl.handle.net/10400.14/25366.

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Brands play an important role in consumers’ daily lives. When consumers struggle with a difficult task they use certain brands to help them perform better. Several studies have shown that brand use can enhance feelings of self-efficacy, which can lead to better task performance. In this dissertation we propose that consumption of a brand that carries performance-enhancing expectations results in psychological changes for consumers (self-signalling and perceptions of self-efficacy) that in turn improve an individual’s perceptions of performance outcomes. Besides, we test the same effects with b

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15

Kovář, Martin. "Krvetvorba u mihule mořské." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-355668.

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To find out if the haematopoietic system is common feature of vertebrates, we decided to examine haematopoiesis in a sea lamprey (Petromyzon marinus). All blood cells arises from the haematopoietic stem cells in higher vertebrates. We assume that this is common for the higher vertebrates and a jawless vertebrates, but nobody was interested in the jawless haematopoiesis since 1970. Using a reverse genetic, we identify homologues of important hematopoietic of higher vertebrates in transcriptome of the sea lamprey with emphasis on important receptors or transcription factors, because they can be

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16

Ng, Ching Wa. "Self-styled integrated reporting: evidence from the 2012 annual reports of Hong Kong’s top 100 listed companies." Thesis, 2015. http://hdl.handle.net/1959.13/1061127.

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Professional Doctorate - Doctor of Business Administration (DBA)<br>Corporate reporting is a reflection of fiscal actions critical for business performance appraisal and market capital justification. Internationally regulated financial statements are produced on historical records. The collapse of several giant U.S.-listed corporates in 2002 surfaced a management loophole in corporate governance. The conflict between owners and managers might drive corporate management to conceal under-performed operations through creative financial tools and accounting policies, a practice which is dangerous

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