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Journal articles on the topic 'Semi-lobar'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Taori, K., N. Sardesai, V. Ingle, and V. Patil. ""Semi lobar holoprosencephaly"- a case report." Indian Journal of Radiology and Imaging 15, no. 4 (2005): 576. http://dx.doi.org/10.4103/0971-3026.29177.

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2

Kandoussi, Hajar, Khaoula Laaboub, Hounaida Mahfoud, and Zaki Elhanchi. "Semi-Lobar Holoprosencephaly Diagnosed at Term: The Critical Role of Prenatal Diagnosis." Scholars Journal of Medical Case Reports 13, no. 07 (2025): 1574–77. https://doi.org/10.36347/sjmcr.2025.v13i07.012.

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Objective: To report a case of semi-lobar holoprosencephaly (HPE) diagnosed at term in the context of an unmonitored diabetic pregnancy, emphasizing the importance of early prenatal screening. Case Report: A primigravida with poorly controlled type 1 diabetes and no structured prenatal care was admitted in preterm labor at 36 weeks. An emergency ultrasound revealed intrauterine growth restriction, microcephaly, and semi-lobar HPE with major facial dysmorphism (hypotelorism, single nostril). The infant was delivered vaginally. At birth, the newborn exhibited profound clinical signs of life-thre

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Jing, Hongkui, Judy Flax, Cynthia P. Roesler, Naseem Choudhury, and April A. Benasich. "Auditory event-related responses in children with semi-lobar holoprosencephaly." Brain and Development 28, no. 4 (2006): 207–14. http://dx.doi.org/10.1016/j.braindev.2005.07.005.

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Jalal, Mohammed, Imane El Abbassi, Ayoub Amghar, Amine Lamrissi, and Said Bouhya. "Alobar holoprosencephaly: A case report." Edorium Journal of Gynecology and Obstetrics 7, no. 2 (2023): 1–4. http://dx.doi.org/10.5348/100032g06mj2023cr.

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Introduction: Holoprosencephaly (HPE) is a rare brain malformation, which results from a cleavage defect of the prosencephalon. Three forms have been described as: alobar, semi-lobar, and lobar forms. Case Report: We report a rare case of holoprosencephaly, diagnosed at the maternity of the Ibn Rochd Hospital Center in Casablanca. Conclusion: Holoprosencephaly is secondary to a cleavage anomaly of the prosencephalon, the diagnosis is based on echotomography, computed tomography (CT) scan and nuclear magnetic resonance imaging (MRI). It is important to perform a karyotype to look for a chromoso

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International, Journal of Medical Science and Innovative Research (IJMSIR). "Holoprosencephaly – Case Reports of A Rare Neurological Malformation." 2458-8687 9, no. 6 (2024): 07–12. https://doi.org/10.5281/zenodo.15448661.

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<strong>Abstract</strong> Holoprosencephaly (HPE) is a complex structural anomaly of the developing forebrain caused by incomplete division of prosencephalon into two separate hemispheres and ventricles resulting in dysmorphism of brain and face and neurological impairment. HPE has incidence rate of 1:250 in utero and the live birth rate is 1:16,000. It is classified into three types based on the degree of cerebral involvement; lobar, semi-lobar and alobar. There are various etiological factors involved in causation of Holoprosencephaly including environmental, chromosomal and genetic syndrome

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Sharif, Md Mofazzal, Khaleda Parvin, Md Towhidur Rahman, Nayeem Ullah, and Saiful Islam. "Two Cases of Holoprosencephalies." KYAMC Journal 8, no. 1 (2017): 64–68. http://dx.doi.org/10.3329/kyamcj.v8i1.33878.

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Two pregnant women with around 33-34 weeks of gestation were reported to Gynaecology and Obstetrics OPD of North Bengal Medical College Hospital, Bangladesh for last trimester antenatal checkup. They were primigravida with around 23-25 years of ages without previous antenatal check up. Both of them had normal course of pregnancy. Ultrasounds of pregnancy profile were done. It was observed in first case that septum pellucidum was absent in brain with partially formed falx cerebri, interhemispheric fissure. Occipital horn was rudimentary and thalami and basal ganglia were partially separated. Th

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Razali, Renardy Reza, and Muhammad Ilham Harahap. "Cyclopia syndrome in a 34-week foetus." International Surgery Journal 11, no. 7 (2024): 1165–67. http://dx.doi.org/10.18203/2349-2902.isj20241748.

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Cyclopia is a rare genetic birth defect with an incidence of approximately 1 in 13,000 to 20,000 newborns. This condition is marked by the failure of the eye orbits to properly divide, resulting in a single eye field or closely positioned eye fields. Additional features include a missing or dysfunctional nose and malformed ears. Most embryos with this condition are aborted, stillborn, or die shortly after birth. This case report discusses the 34-week pregnancy of a 36-year-old woman referred to Arifin Achmad Hospital. Ultrasound revealed midline fusion of the foetal head and thalamus, leading

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Novosadova, O. A., V. N. Grigoryeva, P. A. Astanin, M. A. Lesnikov, and A. S. Samodurov. "Clinical and non-hemorrhagic neuroimaging indicators of probable cerebral amyloid angiopathy as a cause of non-traumatic lobar hematomas." Perm Medical Journal 41, no. 3 (2024): 15–27. http://dx.doi.org/10.17816/pmj41315-27.

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Objective. To identify clinical and non-hemorrhagic neuroimaging indicators of probable CAA in patients with acute non-traumatic lobar hematomas. Cerebral amyloid angiopathy (CAA) is a microangiopathy affecting the leptomeningial and cortical vessels of the brain due to the deposition of pathological b-amyloid in them. The most common clinical manifestation of CAA is lobar hematomas (LH) – spontaneous intracerebral hemorrhages localized between the cerebral cortex and basal ganglia. LH can also occur in hypertensive cerebral microangiopathy (hCMA) in patients with arterial hypertension. Since

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Shrestha, Dhruba, Ganendra Raya, Amar Prajapati, Suruchi Dhaubhadel, Sushmita Puri, and Dybesh Regmi. "Radiographically Confirmed Community-Acquired Pneumonia in Pediatric Patients Prior to Pneumococcal Vaccination in Nepal." Journal of Pediatric Infectious Diseases 13, no. 01 (2017): 057–62. http://dx.doi.org/10.1055/s-0037-1607266.

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Background The massive burden of pediatric pneumonia is associated with high morbidity and mortality, particularly in developing countries where immunization programs are absent or recently been implemented. The objective of this study was to describe the number of hospitalizations and outcomes of children aged 1 month to 10 years with community-acquired pneumonia (CAP) between January 1, 2014, and June 30, 2015, in semi-rural Nepal. Methods This retrospective study was undertaken prior to the implementation of the pneumococcal conjugate vaccination (PCV) program in Bhaktapur district of Nepal

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Jahan Khan, M. Delwar, M. Ashraful Islam, Kazi Raiyan Hoque, et al. "The relationship between lobar distribution and primary lung cancer histological types." International Journal of Advances in Medicine 11, no. 5 (2024): 449–54. http://dx.doi.org/10.18203/2349-3933.ijam20242307.

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Background: Lung cancer is the primary cause of cancer-related deaths globally. Accurate tumor location and subtype characterization are critical for optimizing treatment and predicting outcomes. This study aims to identify the relationship between lobar distribution and primary lung cancer histological types and describe the most recent patterns at the country-level origin. Methods: This cross-sectional study was conducted at a major tertiary care hospital in Bangladesh, including 165 patients recruited using purposive non-probability sampling. Data were collected using a semi-structured case

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Graff-Radford, Jonathan, Eider M. Arenaza-Urquijo, David S. Knopman, et al. "White matter hyperintensities: relationship to amyloid and tau burden." Brain 142, no. 8 (2019): 2483–91. http://dx.doi.org/10.1093/brain/awz162.

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Abstract Although white matter hyperintensities have traditionally been viewed as a marker of vascular disease, recent pathology studies have found an association between white matter hyperintensities and Alzheimer’s disease pathologies. The objectives of this study were to investigate the topographic patterns of white matter hyperintensities associated with Alzheimer’s disease biomarkers measured using PET. From the population-based Mayo Clinic Study of Aging, 434 participants without dementia (55% male) with FLAIR and gradient recall echo MRI, tau-PET (AV-1451) and amyloid-PET scans were ide

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Lant, Suzannah B., Andrew C. Robinson, Jennifer C. Thompson, et al. "Patterns of Microglial Cell Activation in Frontotemporal Lobar Degeneration." Neuropathology and Applied Neurobiology 40, no. 6 (2013): 686–96. https://doi.org/10.1111/nan.12092.

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AIMS: Pathological heterogeneity within patients with Frontotemporal lobar degeneration (FTLD) in general precludes the accurate assignment of diagnostic subtype in life. The aim of this study was to assess the extent of microglial cell activation in FTLD in order to determine whether it might be possible to employ this as a diagnostic marker in vivo using PET ligand [11C](R)-PK11195 in order to differentiate cases of FTLD according to histological subtype. METHODS: The distribution and extent of microglial cell activation was assessed semi-quantitatively in cortical grey and subcort

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Lugarà, Marina, Stefania Tamburrini, Maria Gabriella Coppola, et al. "The Role of Lung Ultrasound in SARS-CoV-19 Pneumonia Management." Diagnostics 12, no. 8 (2022): 1856. http://dx.doi.org/10.3390/diagnostics12081856.

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Purpose: We aimed to assess the role of lung ultrasound (LUS) in the diagnosis and prognosis of SARS-CoV-2 pneumonia, by comparing it with High Resolution Computed Tomography (HRCT). Patients and methods: All consecutive patients with laboratory-confirmed SARS-CoV-2 infection and hospitalized in COVID Centers were enrolled. LUS and HRCT were carried out on all patients by expert operators within 48–72 h of admission. A four-level scoring system computed in 12 regions of the chest was used to categorize the ultrasound imaging, from 0 (absence of visible alterations with ultrasound) to 3 (large

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Kline, Cassie, Schuyler Stoller, Lennox Byer, et al. "NCOG-71. GENOME ASSOCIATIONS WITH NEUROCOGNITIVE OUTCOMES, CEREBRAL MICROBLEEDS (CMBS), AND BRAIN VOLUME AND WHITE MATTER (WM) CHANGES IN PEDIATRIC BRAIN TUMOR SURVIVORS." Neuro-Oncology 22, Supplement_2 (2020): ii145. http://dx.doi.org/10.1093/neuonc/noaa215.609.

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Abstract OBJECTIVE To identify genetic predictors of neurocognition, CMBs, brain volume, and WM changes in pediatric brain tumor survivors. METHODS Patients were selected from an existing cohort (RadART) if they had: 1) at least one neurocognitive evaluation using computer-based CogState; 2) available DNA; 3) standard imaging. Candidate gene or genome-wide genotyping was performed on all patients. CMBs were identified using a semi-automated algorithm developed in MATLAB. Volume of T2/FLAIR WM signal abnormality was measured using a semi-automated method based on a convolutional neural network.

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Kline, Cassie, Schuyler Stoller, Lennox Byer, et al. "QOL-53. GENOME ASSOCIATIONS WITH NEUROCOGNITIVE OUTCOMES, CEREBRAL MICROBLEEDS (CMBS), AND BRAIN VOLUME AND WHITE MATTER (WM) CHANGES IN PEDIATRIC BRAIN TUMOR SURVIVORS." Neuro-Oncology 22, Supplement_3 (2020): iii440. http://dx.doi.org/10.1093/neuonc/noaa222.706.

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Abstract OBJECTIVE To identify genetic predictors of neurocognition, CMBs, brain volume, and WM changes in pediatric brain tumor survivors. METHODS Patients were selected from an existing cohort (RadART) if they had: 1) at least one neurocognitive evaluation using computer-based CogState; 2) available DNA; 3) standard imaging. Candidate gene or genome-wide genotyping was performed on all patients. CMBs were identified using a semi-automated algorithm developed in MATLAB. Volume of T2/FLAIR WM signal abnormality was measured using a semi-automated method based on a convolutional neural network.

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Hasan, M., MR Islam, A. Matin, et al. "Clinical Profile of Children with Pleural Effusion Admitted In a Tertiary Care Hospital of Bangladesh." Journal of Shaheed Suhrawardy Medical College 4, no. 1 (2012): 7–9. http://dx.doi.org/10.3329/jssmc.v4i1.11995.

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Background: Pleural effusion is a problem commonly encountered by chest physicians. Objective: This study was an attempt to know the clinical presentation in order to avoid delay in diagnosis that may influence treatment and outcome. Methods: This cross-sectional study of thirty (30) admitted cases with pleural effusion were confirmed by chest radiography and aspiration of pleural fluid from one (1) year to twelve (12) years age of either sex the patientdwere selected purposively, was studied from July 2009 to Feb 2010 in the Department of Pediatrics, Rajshahi Medical College Hospital . All in

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Kayastha, Rumita, Riwaz Acharya, Sunil Pradhan, Abhushan Siddhi Tuladhar, and Amit Shrestha. "High Resolution Computed Tomography chest findings among people affected by corona virus disease in a tertiary hospital of Nepal." Nepal Medical College Journal 25, no. 3 (2023): 203–10. http://dx.doi.org/10.3126/nmcj.v25i3.58712.

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Clinical assessment, chest X-ray (CXR) and chest high-resolution computed tomography (HRCT) are used in the management of Corona virus disease-19 (COVID-19). This retrospective cross sectional study included 251 patients admitted to Nepal Medical College Teaching Hospital (NMCTH) with a diagnosis of COVID‑19 infection confirmed by Reverse Transcriptase- Polymerase Chain Reaction (RT‑PCR). These patients underwent chest HRCT within the first two weeks of hospital admission. Images were evaluated for various HRCT findings & semi- quantitative CT Severity Score (CT –SS) was calculated based o

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Murley, Alexander G., Matthew A. Rouse, P. Simon Jones, et al. "GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition." Brain 143, no. 11 (2020): 3449–62. http://dx.doi.org/10.1093/brain/awaa305.

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Abstract Behavioural disinhibition is a common feature of the syndromes associated with frontotemporal lobar degeneration (FTLD). It is associated with high morbidity and lacks proven symptomatic treatments. A potential therapeutic strategy is to correct the neurotransmitter deficits associated with FTLD, thereby improving behaviour. Reductions in the neurotransmitters glutamate and GABA correlate with impulsive behaviour in several neuropsychiatric diseases and there is post-mortem evidence of their deficit in FTLD. Here, we tested the hypothesis that prefrontal glutamate and GABA levels are

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Patel, Sunil Kumar, Shital Adhikari, Basanta Gauli, et al. "ASSOCIATION OF CRP AND D-DIMER WITH CT SEVERITY SCORING IN COVID-19 PATIENTS." Journal of Chitwan Medical College 11, no. 4 (2022): 120–25. http://dx.doi.org/10.54530/jcmc.538.

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Background: Corona virus disease 2019 (COVID-19) has become a global public health issue with significant impacts upon the healthcare delivery systems. Previous studies have consistently found elevated levels of C-Reactive Protein and D-dimer with disease severity. In this study, we aimed to investigate the relationship between C-Reactive Protein, D-dimer level and Computed Tomography severity score in patients with SARS-COV-2 pneumonia. Methods: Our study included 76 patients with COVID-19, admitted in COVID Unit of Chitwan Medical College and Teaching Hospital from June 2020 to December 2020

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Nevesny, Franck, David C. Rotzinger, Alexander W. Sauter, et al. "Acute Pulmonary Embolism in COVID-19: A Potential Connection between Venous Congestion and Thrombus Distribution." Biomedicines 10, no. 6 (2022): 1300. http://dx.doi.org/10.3390/biomedicines10061300.

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Background: Vascular abnormalities, including venous congestion (VC) and pulmonary embolism (PE), have been recognized as frequent COVID-19 imaging patterns and proposed as severity markers. However, the underlying pathophysiological mechanisms remain unclear. In this study, we aimed to characterize the relationship between VC, PE distribution, and alveolar opacities (AO). Methods: This multicenter observational registry (clinicaltrials.gov identifier NCT04824313) included 268 patients diagnosed with SARS-CoV-2 infection and subjected to contrast-enhanced CT between March and June 2020. Acute

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Dehghani, Sadegh, Fahimeh Zeinalkhani, Mojtaba Amiri, et al. "The Evaluation of Correlation between Clinical Characteristics and Chest CT Findings in Recovered and Dead COVID-19 Patients." EAS Journal of Radiology and Imaging Technology 6, no. 04 (2024): 48–54. http://dx.doi.org/10.36349/easjrit.2024.v06i04.003.

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Objectives: The purpose of this study was to retrospectively investigate the correlation between clinical characteristics and chest CT findings in recovered and dead covid-19 patients. Patients: In this retrospective study, 63 hospitalized patients infected with COVID-19 were reviewed, from 1 May 2020 to 30 Dec 2020. The lobe involvement and infection pattern were evaluated in both groups. A semi-quantitative CT score was calculated based on the extent of lobar involvement (0 indicate no involvement; 1, less than 5% involvement; 2, 5-25% involvement; 3, 26%–50% involvement; 4, 51%–75% involvem

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Sah, Vijay Kumar, Arun Giri, and Niraj Niraula. "Association between the clinical findings and chest radiographs in children with severe pneumonia aged 1 month to 5 years." Journal of Nobel Medical College 7, no. 2 (2018): 15–19. http://dx.doi.org/10.3126/jonmc.v7i2.22288.

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Background: Pneumonia is the main cause of death among children under five years of age particularly in developing countries. According to the WHO, there are more than 15 million cases representing 7-13% of pneumonia cases annually which necessitate hospital admission due to their severity. There is paucity of data regarding the clinical spectrum and the epidemiology of severe pneumonia from eastern part of Nepal. It is important to understand the clinical spectrum and the epidemiology of severe pneumonia at local level to better define problem and to draw inferences for management and policy

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Berisha, Destiny, Batool Rizvi, Miranda G. Chappel-Farley, et al. "0752 Regional Cerebrovascular Pathology Is Associated with Local Disruptions in Non-rapid Eye Movement Sleep Expression." SLEEP 47, Supplement_1 (2024): A322. http://dx.doi.org/10.1093/sleep/zsae067.0752.

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Abstract Introduction Aging is associated with disruptions in non-rapid eye movement (NREM) sleep expression, but the mechanisms driving this effect remain unclear. Cerebral small vessel disease (CSVD) burden increases with age and is associated with clinical sleep disturbance, but little is known about its relationship with local expression of oscillatory activity during NREM sleep. Here, we explore associations between CSVD burden and local electroencephalography (EEG) measures during NREM sleep in older adults. Methods Fifteen cognitively intact older adults (mean age 71.8±6.3 years, 10 fem

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Haibel, H., J. L. Vahldiek, S. Angermair, et al. "POS1209 SUCCESSFUL TREATMENT OF SEVERE COVID-19 PNEUMONIA AND CYTOKINE RELEASE WITH SIMULTANEOUS TOCILIZUMAB AND ANAKINRA WITH ONE-MONTH FOLLOW-UP." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 887.2–888. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2289.

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Background:Severe and life threating COVID-19 pneumonia is often characterized by local and systemic immune-mediated hyperinflammation At the early disease stage activated monocytes are migrating to the lung and cause the typical opac infiltrates, which lead to an reduction of oxygen uptake. These pathophysiological observations and the fact that corticosteroids are so far the only drug, which has shown significant improvement, was the rationale use this combination anti-inflammatory drugs in severe Covid-19 disease. Interleukin (IL)-6 and IL-1 blockade alone, respectively showed contradictory

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Grodecki, Kajetan, Aditya Killekar, Judit Simon, et al. "Artificial Intelligence-assisted quantification of COVID-19 pneumonia burden from computed tomography improves prediction of adverse outcomes over visual scoring systems." British Journal of Radiology, June 13, 2023. http://dx.doi.org/10.1259/bjr.20220180.

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Objectives: We aimed to evaluate the effectiveness of utilizing artificial intelligence (AI) to quantify the extent of pneumonia from chest computed tomography (CT) scans, and to determine its ability to predict clinical deterioration or mortality in patients admitted to the hospital with COVID-19in comparison to semi-quantitative visual scoring systems. Methods: A deep-learning algorithm was utilized to quantify the pneumonia burden, while semi-quantitative pneumonia severity scores were estimated through visual means. The primary outcomewas clinical deterioration, the composite endpoint incl

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Cospain, Auriane, Marie Faoucher, Aurélie Cauchois, Wilfrid Carre, Chloé Quelin, and Christèle Dubourg. "Fetal Description of the Pancreatic Agenesis and Holoprosencephaly Syndrome Associated to a Specific CNOT1 Variant." Pediatric and Developmental Pathology, April 28, 2022, 109352662210953. http://dx.doi.org/10.1177/10935266221095305.

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Holoprosencephaly (HPE) is a clinically and genetically heterogeneous disease, which can be associated with various prenatal comorbidities not always detectable on prenatal ultrasound. We report on the case of a foetus carrying a semi-lobar HPE diagnosed at ultrasound, for which a fetal autopsy and a whole exome sequencing were performed following a medical termination of pregnancy. Neuropathological examination confirmed the semi-lobar HPE and general autopsy disclosed a total pancreas agenesis. Whole exome sequencing found the CNOT1 missense c.1603C>T, p.(Arg535Cys), occurring de novo in

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Gerard, Sarah E., Jacob Herrmann, Yi Xin, et al. "CT image segmentation for inflamed and fibrotic lungs using a multi-resolution convolutional neural network." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-020-80936-4.

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AbstractThe purpose of this study was to develop a fully-automated segmentation algorithm, robust to various density enhancing lung abnormalities, to facilitate rapid quantitative analysis of computed tomography images. A polymorphic training approach is proposed, in which both specifically labeled left and right lungs of humans with COPD, and nonspecifically labeled lungs of animals with acute lung injury, were incorporated into training a single neural network. The resulting network is intended for predicting left and right lung regions in humans with or without diffuse opacification and con

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Martinez-Ramirez, Sergi, Octavio Pontes-Neto, Andrew P. Dumas, et al. "Abstract WP226: Topography of Dilated Perivascular Spaces in Patients with Markers of Cerebral Amyloid Angiopathy and Hypertensive Vasculopathy." Stroke 44, suppl_1 (2013). http://dx.doi.org/10.1161/str.44.suppl_1.awp226.

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Objectives: To investigate whether the topography of dilated perivascular spaces (DPVS) corresponds with markers of particular small vessel diseases such as cerebral amyloid angiopathy (CAA) and hypertensive vasculopathy. Methods: Patients were recruited from an ongoing single-center prospective longitudinal cohort study of patients evaluated in a memory clinic. All patients underwent structural, high-resolution MRI, and had a clinical assessment performed within 1 year of scan. DPVS were rated in basal ganglia (BG-DPVS) and white matter (WM-DPVS) on T1 sequences, using an established 4-point

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Falcone, Guido J., Alessandro Biffi, H. B. Brouwers, et al. "Abstract WP306: Determinants of Hematoma Volume Differ by Location in Intracerebral Hemorrhage." Stroke 44, suppl_1 (2013). http://dx.doi.org/10.1161/str.44.suppl_1.awp306.

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Background and purpose: Admission hematoma volume (AHV) is the strongest predictor of outcome in intracerebral hemorrhage (ICH). Mounting evidence suggests that the biological mechanisms underlying ICH occurrence differ by bleeding location. We aimed to assess if the determinants of AHV vary by bleeding topography, and to estimate location-specific effects for warfarin, a factor known to influence AHV. Methods: Retrospective analysis of 902 ICH cases (388 deep, 356 lobar and 58 cerebellar) enrolled in a single-center, prospective study of ICH. AHV was measured in the first available computed t

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Brissette, Vincent, Menglu Ouyang, Vignan Yogendrakumar, et al. "Abstract 86: Location-Specific Hematoma Volume Tolerance for Spontaneous Intracerebral Hemorrhage." Stroke 56, Suppl_1 (2025). https://doi.org/10.1161/str.56.suppl_1.86.

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Background: Hematoma volume is an important predictor of outcome in spontaneous intracerebral hemorrhage (ICH). Location-specific hematoma volume thresholds are associated with poor outcome and can inform surgical trial inclusion criteria and clinical decision rules for hematoma evacuation. In a pooled trial dataset, we evaluated associations between ICH location, hematoma volume thresholds, and patient outcomes. Methods: We performed a secondary analysis of the ATACH-2 clinical trial. We evaluated the associations between intraparenchymal location-specific hematoma volume cutoffs (thalamic, b

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Vogt, Julia Katharina, Wolfgang Kurt Vogt, Alexander Heinzel, and Felix M. Mottaghy. "Computational Decision Support for PE Diagnosis based on Ventilation Perfusion Ratio." Nuklearmedizin - NuclearMedicine, April 9, 2024. http://dx.doi.org/10.1055/a-2287-2051.

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Abstract Aim The aim of this study is to investigate whether computer-aided, semi-automated 3D lung lobe quantification can support decision-making on PE diagnosis based on the ventilation-perfusion ratio in clinical practice. Methods A study cohort of 100 patients (39 male, 61 female, age 64.8±15.8 years) underwent ventilation/perfusion single photon emission computed tomography (V/Q-SPECT/CT) to exclude acute PE on SPECT/CT OPTIMA NM/CT 640 (GE Healthcare). Two 3D lung lobe quantification software tools (Q. Lung: Xeleris 4.0, GE Healthcare and LLQ: Hermes Hybrid 3D Lung Lobar Quantification,

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Carey, Katherine J., Peter Hotvedt, David G. Mummy, et al. "Comparison of hyperpolarized 3He-MRI, CT based parametric response mapping, and mucus scores in asthmatics." Frontiers in Physiology 14 (August 1, 2023). http://dx.doi.org/10.3389/fphys.2023.1178339.

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Purpose: The purpose of this study was to anatomically correlate ventilation defects with regions of air trapping by whole lung, lung lobe, and airway segment in the context of airway mucus plugging in asthma.Methods: A total of 34 asthmatics [13M:21F, 13 mild/moderate, median age (range) of 49.5 (36.8—53.3) years and 21 severe, 56.1 (47.1—62.6) years] and 4 healthy subjects [1M:3F, 38.5 (26.6—52.2) years] underwent HP 3He MRI and CT imaging. HP 3He MRI was assessed for ventilation defects using a semi-automated k-means clustering algorithm. Inspiratory and expiratory CTs were analyzed using p

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Mao, Andrew, Sebastian Flassbeck, Elisa Marchetto, Arjun V. Masurkar, Henry Rusinek, and Jakob Assländera. "Sensitivity of unconstrained quantitative magnetization transfer MRI to Amyloid burden in preclinical Alzheimer’s disease." Imaging Neuroscience, 2024. http://dx.doi.org/10.1162/imag_a_00367.

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Abstract Magnetization transfer MRI is sensitive to semi-solid macromolecules, including amyloid beta, and has previously been used to discriminate Alzheimer’s disease (AD) patients from controls. Here, we fit an unconstrained 2-pool quantitative MT (qMT) model, i.e., without constraints on the longitudinal relaxation rate R1S of semi-solids, and investigate the sensitivity of the estimated parameters to amyloid accumulation in preclinical participants. We scanned 15 cognitively normal volunteers, of which 9 were amyloid positive by [18F]Florbetaben PET. A 12 min hybrid-state qMT scan with an

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Sarnat, Harvey B., Weiming Yu, and Laura Flores-Sarnat. "Keratan sulfate proteoglycan as an axonal insulating barrier in the forebrain of fetuses with alobar/semi-lobar holoprosencephaly." Clinical Neuropathology, December 8, 2020. http://dx.doi.org/10.5414/np301317.

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Atif, Rasool Kawoosa Sajad Ahmed Tak, and Naqash. Hena. "CLINICAL PROFILE OF INTRA-CEREBRAL HAEMORRHAGIC STROKE PATIENTS IN AN ETHNIC POPULATION OF NORTH INDIA." April 3, 2019. https://doi.org/10.5281/zenodo.2864022.

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Introduction:Given the high prevalence of Intra Cerebral Haemorrhage (ICH) in the Kashmir Valley, an associated very high morbidity and mortality and the scarcity of studies from our part of the world, it becomes relevant and prudent to study the clinical parameters of ICH in our Valley which in turn would potentially be translated into preventive measures. Aim: We aimed to study various clinico-biochemical parameters of the ICH patients in our region. Methodology: We studied 150 consecutive ICH patients admitted to our hospital, including their age, gender, blood pressures, NCCTs and ICH scor

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Inamdar, A. V. "Correlation of chest CT severity score with D-dimer levels in patients with COVID-19." European Heart Journal 42, Supplement_1 (2021). http://dx.doi.org/10.1093/eurheartj/ehab724.1285.

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Abstract Background Coronavirus disease 2019 (COVID 19) caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) predominantly affects lungs and leads to COVID-19 pneumonia. Studies have shown that COVID 19 is hypercoagulative prothrombotic state. The innate tropism of SARS CoV-2 for vascular endothelial cells and their consequent damage, together with the intense activation of inflammatory responses and of coagulation pathways, may explain the intense pro-coagulative state. It ultimately predisposes to systemic micro-thrombotic alterations and gives rise to the consistent rate

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Hansen, Jacob V., Mette W. Poulsen, Jens E. Nielsen‐Kudsk, Mannudeep K. Kalra, Mads D. Lyhne, and Asger Andersen. "Quantitative pulmonary perfusion in acute pulmonary embolism and chronic thromboembolic pulmonary hypertension." Pulmonary Circulation 14, no. 4 (2024). http://dx.doi.org/10.1002/pul2.12445.

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AbstractCurrent methods for quantifying perfusion from computed tomography pulmonary angiography (CTPA) often rely on semi‐quantitative scoring systems and requires an experienced evaluator. Few studies report on absolute quantitative variables derived from the images, and the methods are varied with mixed results. Dual‐energy CTPA (DE‐CTPA) enables automatic quantification of lung and lobar perfusion with minimal user interaction by utilizing machine learning based software. We aimed to evaluate differences in DE‐CTPA derived quantitative perfusion variables between patients with acute pulmon

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Carlos, Arenn F., Stephen D. Weigand, Nha Trang Thu Pham, et al. "White matter hyperintensities and TDP‐43 pathology in Alzheimer's disease." Alzheimer's & Dementia, January 17, 2025. https://doi.org/10.1002/alz.14516.

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AbstractINTRODUCTIONGreater white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) are seen with transactive response DNA‐binding protein 43 (TDP‐43) pathology in frontotemporal lobar degeneration (FTLD‐TDP). WMH associations with TDP‐43 pathology in Alzheimer's disease (AD‐TDP) remain unclear.METHODSA total of 157 participants from Mayo Clinic Rochester with autopsy‐confirmed AD, known TDP‐43 status, and antemortem fluid‐attenuated inversion recovery (FLAIR) MRI were included. Vascular risk factors were assessed. A semi‐automated WMH segmentation‐quantification process produ

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Guan, Xiaojun, Liding Yao, Yanbin Tan, et al. "Quantitative and semi-quantitative CT assessments of lung lesion burden in COVID-19 pneumonia." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-84561-7.

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AbstractThis study aimed to clarify and provide clinical evidence for which computed tomography (CT) assessment method can more appropriately reflect lung lesion burden of the COVID-19 pneumonia. A total of 244 COVID-19 patients were recruited from three local hospitals. All the patients were assigned to mild, common and severe types. Semi-quantitative assessment methods, e.g., lobar-, segmental-based CT scores and opacity-weighted score, and quantitative assessment method, i.e., lesion volume quantification, were applied to quantify the lung lesions. All four assessment methods had high inter

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Kwak, Daniel H., Alex Lionberg, Mikin Patel, et al. "Quantitative Differences in Volumetric Calculations for Radiation Dosimetry in Segmental Y90 Treatment Planning using Hybrid Angiography-CT (Angio-CT) Compared with Anatomic Segmentation." British Journal of Radiology, January 4, 2024. http://dx.doi.org/10.1093/bjr/tqad056.

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Abstract Objective To compare treatment volumes reconstructed from hybrid Angio-CT catheter-directed infusion imaging and Couinaud anatomic model as well as the implied differences in Y-90 radiation dosimetry. Materials and Methods Patients who underwent transarterial radioembolization (TARE) using Y-90 glass microspheres with pretreatment CT or MRI imaging as well as intraprocedural angiography-CT (Angio-CT) were analyzed. Treatment volumes were delineated using both tumoral angiosomes (derived from Angio-CT) and Couinaud anatomic landmarks. Segmental and lobar treatment volumes were calculat

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Lin, Chia-Yen, Song-Ru Jhan, Wei-Ju Lee, et al. "Imaging Markers of Subcortical Vascular Dementia in Patients With Multiple-Lobar Cerebral Microbleeds." Frontiers in Neurology 12 (November 12, 2021). http://dx.doi.org/10.3389/fneur.2021.747536.

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Background and Purpose: Small vessel disease (SVD) imaging markers are related to ischemic and hemorrhage stroke and to cognitive dysfunction. This study aimed to clarify the relationship between SVD imaging markers and subcortical vascular dementia in severe SVD burden.Methods: A total of 57 subjects with multiple lobar cerebral microbleeds (CMBs) and four established SVD imaging markers were enrolled from the dementia and stroke registries of a single center. Visual rating scales that are used to semi-quantify SVD imaging changes were analyzed individually and compositely to make correlation

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Blanc, Clémence, Marion Houot, Nicolas Villain, et al. "Cerebral amyloid angiopathy frequency at baseline and after 4 years of follow‐up in the INSIGHT‐preAD study." Alzheimer's & Dementia 19, S16 (2023). http://dx.doi.org/10.1002/alz.076934.

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AbstractBackgroundCerebral amyloid angiopathy (CAA) diagnostic is of special interest due to its association with cognitive impairment, Alzheimer disease (AD) and Amyloid‐Related Imaging Abnormalities (ARIA) in trials with anti‐amyloid immunotherapies. We aimed to assess the frequency of CAA diagnosis and associated lesions in subjects with cognitive complaint and normal cognition enrolled in the INSIGHT‐preAD study.MethodCognitively normal elderly with memory complaint included in the INSIGHT‐preAD study were assessed with multimodal explorations for 5 years follow‐up. 3T MRI‐scans were perfo

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Giannini, Lucia AA, Merel O. Mol, Ana Rajicic, et al. "Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration." Acta Neuropathologica Communications 11, no. 1 (2023). http://dx.doi.org/10.1186/s40478-023-01588-9.

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AbstractEarly pathological features of frontotemporal lobar degeneration (FTLD) due to MAPT pathogenic variants (FTLD-MAPT) are understudied, since early-stage tissue is rarely available. Here, we report unique pathological data from three presymptomatic/early-stage MAPT variant carriers (FTLD Clinical Dementia Rating [FTLD-CDR] = 0–1). We examined neuronal degeneration semi-quantitatively and digitally quantified tau burden in 18 grey matter (9 cortical, 9 subcortical) and 13 white matter (9 cortical, 4 subcortical) regions. We compared presymptomatic/early-stage pathology to an intermediate/

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Audousset, Camille, Sana Swaleh, Ron Olivenstein, et al. "Mucus plugs in the airways of asthmatic subjects and smoking status." Respiratory Research 25, no. 1 (2024). http://dx.doi.org/10.1186/s12931-024-02665-w.

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Abstract Background Mucus plugs have been described in the airways of asthmatic subjects, particularly those with associated with type 2 inflammation and sputum eosinophilia. In the current study we addressed the question of whether smoking, neutrophilic inflammation and airway dimensions affected the prevalence of mucus plugs. Methods In a cohort of moderate to severe asthmatics (n = 50), including a group of ex-smokers and current smokers, the prevalence of mucus plugs was quantified using a semi-quantitative score based on thoracic computerized tomography. The relationships between mucus sc

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Anastasi, Emanuela, Lucia Manganaro, Elisa Guiducci, et al. "Association of serum Krebs von den Lungen-6 and chest CT as potential prognostic factors in severe acute respiratory syndrome SARS-CoV-2: a preliminary experience." La radiologia medica, June 15, 2022. http://dx.doi.org/10.1007/s11547-022-01504-6.

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Abstract Purpose To correlate in COVID-19 pneumonia CT-based semi-quantitative score of pulmonary involvement with high serum levels of KL-6, a biomarker of disease severity. Methods Between March 28 to May 21, 2020, 196 patients with strong suspicion of SARS-CoV-2 were evaluated with RT-PCR for SARS-CoV-2, chest CT scan and blood test, including KL-6 serum protein, in our Emergency Unit. The final population included only patients who underwent blood sampling for KL-6 within 5 days from CT scan (n = 63), including n = 37 COVID-19-positive patients and n = 26 with negative RT-PCR testing for S

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Mohammaden, Mahmoud, Leonardo Pisani, Catarina Perry da Camara, et al. "Abstract TP90: Advance: Automated Detection and Volumetric Assessment of Intracerebral Hemorrhage." Stroke 51, Suppl_1 (2020). http://dx.doi.org/10.1161/str.51.suppl_1.tp90.

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Introduction: Intracerebral hemorrhages (ICHs) accounts for approximately 15% of all strokes but carry high rates of morbidity and mortality. The location and volume of hematoma are strongly associated with outcomes. As novel treatments become established, early detection and proper volume measurement are becoming increasingly important. We aim to evaluate an artificial intelligence-based algorithm (Viz-ICH® v1.4) for ICH detection, volume measurement, and its differentiation from intraventricular hemorrhage (IVH). Methods: We performed single center retrospective analysis of non-contrast CTs

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Watanabe, Ryohei, Shinji Higashi, Takashi Nonaka, et al. "Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions." Acta Neuropathologica Communications 8, no. 1 (2020). http://dx.doi.org/10.1186/s40478-020-01055-9.

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Abstract TAR DNA-binding protein of 43 kDa (TDP-43) is a major component of intracellular aggregates formed in brains of the patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), which are correctively referred to as TDP-43 proteinopathies. A link between Ataxin-2 (ATXN2) and TDP-43 proteinopathies was established when intermediate CAG repeat expansions of ATXN2 gene were found to be associated with ALS and it was shown that ATXN2 modifies TDP-43 toxicity. Although ATXN2’s contribution to TDP-43 proteinopathies has been mostly studied in ALS, recent st

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Molinari, Francesco, Tomasso Pirronti, Nicola Sverzellati, et al. "Intra- and interoperator variability of lobar pulmonary volumes and emphysema scores in patients with chronic obstructive pulmonary disease and emphysema: comparison of manual and semi-automated segmentation techniques." Diagnostic and Interventional Radiology, March 11, 2013. http://dx.doi.org/10.5152/dir.2013.047.

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Cervantes González, Alba, David J. Irwin, Daniel Alcolea, et al. "Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration." Molecular Neurodegeneration 17, no. 1 (2022). http://dx.doi.org/10.1186/s13024-022-00534-y.

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Abstract Background Synapse degeneration is an early event in pathological frontotemporal lobar degeneration (FTLD). Consequently, a surrogate marker of synapse loss could be used to monitor early pathologic changes in patients with underlying FTLD. The aim of this study was to evaluate the relationship of antemortem cerebrospinal fluid (CSF) levels of 8 synaptic proteins with postmortem global tau and TDP-43 burden and cognitive performance and to assess their diagnostic capacity in a neuropathological FTLD cohort. Methods We included patients with a neuropathological confirmation of FTLD-Tau

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Gray, Katherine, Robin Wolz, Natalie Royle, David Werring, Zhiyong Xie, and Theresa Tuthill. "Abstract TP368: Prediction of Hemorrhagic Growth Using Textural Pattern Analysis." Stroke 47, suppl_1 (2016). http://dx.doi.org/10.1161/str.47.suppl_1.tp368.

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Introduction: The subjective characterization of non-contrast CT “swirl sign” along with hematoma volume have been used to predict intracerebral hemorrhage (ICH) growth. As early assessment of patients with acute stroke symptoms can be used to optimize treatment, a more robust, quantitative biomarker set could improve patient care. Hypothesis: Quantification of ICH lesion texture from CT scans taken at less than 3 hours from onset could be used to predict hemorrhagic growth at 24 hours. Methods: Baseline and 24-hour CT scans on 71 ICH stroke subjects were obtained from the Virtual Internationa

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