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Dissertations / Theses on the topic 'Semicarbazoue'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Kaiser, Moacir. "Avaliação pré-clínica em roedores do perfil farmacocinético do benzaldeído semicarbazona livre e complexado em ß-ciclodextrina." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/16458.

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Objetivos: Avaliar a farmacocinética e a distribuição tecidual do benzaldeído semicarbazona livre (BS) e incluso em ß-Ciclodextrinas (BS/ß-CD) após administração de diversas doses por diferentes vias de administração. Metodologia: As concentrações plasmáticas de BS foram quantificadas através de método analítico por CLAE-UV desenvolvido e validado, após administração das doses de 10 mg/kg i.v. bolus e 50 e 100 mg/kg p.o. da droga livre e 10 mg/kg i.v. bolus e 50 mg/kg p.o. da droga complexada a ratos Wistar (n = 8 animais/grupo). Os perfis plasmáticos foram avaliados individualmente pelas abor

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2

Garland, Keira. "A Practical Approach to Semicarbazone and Hydrazone Derivatives via Imino-isocyanates." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30725.

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Isocyanates have a broad spectrum of uses and they are used in the production of many products including polyurethane polymers, coatings, adhesives, paints and foams. While isocyanates are widely studied and well represented in the literature, nitrogen substituted isocyanates are quite rare. Amino and imino-isocyanates are examples of nitrogen substituted isocyanates. Previous work within the group studied the reactivity of these intermediates in the alkene aminocarbonylation reaction, and used hydrazones and hydrazides as precursors of nitrogen substituted isocyanates. From there, a secon

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3

Iffiú-Soltész, Zsuzsa. "Semicarbazide-sensitive amine oxidase substrates in obesity and diabetes." Toulouse 3, 2010. http://thesesups.ups-tlse.fr/1163/.

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L'obésité et le diabète sont de sérieux problèmes de santé dans les pays développés. Le développement de médicaments qui pourraient normaliser un métabolisme glucidique alteré est donc une grande nécessité actuelle. L'amine oxydase sensible au semicarbazide (SSAO) semble être une cible d’intérêt pour améliorer l’homéostasie glucidique. Cette enzyme oxyde les amines primaires. Elle est fortement exprimée dans le tissu adipeux blanc (WAT) et dans les vaisseaux. Sa forme circulante est un facteur indépendant des complications cardiovasculaires du diabète et de l'obésité. Cependant, l'administrati

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4

Queiroz, Aline Cavalcanti de. "Estudos in vitro e in vivo da atividade leishmanicida de novos derivados sintéticos." Universidade Federal de Alagoas, 2015. http://www.repositorio.ufal.br/handle/riufal/1456.

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The arsenal of drugs available for treating Leishmania infections is limited and presents high toxicity. Therefore, new, effective, and less toxic leishmaniasis treatments are still needed. In this work, two series of derivatives, containing a semicarbazone or hydrazide-N- acylhydrazone scaffolds was designed and synthetized as protease inhibitors. From these series, derivatives LASSBio 1483, LASSBio 1705, LASSBio 1707 and LASSBio 1736 highlighted, showing in vitro and in vivo leishmanicidal activities. Thus, these derivatives presented a potent leishmanicidal activity against amastigotes of L

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5

Elliot, Jonathan. "Semicarbazide-sensitive amine oxidase of blood vessels : a functional study." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316733.

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6

Taroua, Mohamed. "Nouveaux dérivés alpha, bêta et gamma-oxime, semicarbazone ou thiosemicarbazone-1,3-dithiolanes à potentialité radioprotectrice : synthèse et radiopharmacologie." Université Joseph Fourier (Grenoble), 1995. http://www.theses.fr/1995GRE18001.

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7

Alomar, Kusai. "Synthèse, caractérisation structurale de complexes de thiosemicarbazones, semicarbazones et oximes mono et bifonctionnelles d'aldéhydes thiophéniques avec des métaux de transition : étude de propriétés biologiques." Angers, 2012. https://theses.hal.science/tel-01277204.

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Les thiosemicarbazones, les semicarbazones et les oximes du thiophéne- 3 -carboxaldéhyde et du thiophene- 2, 3 -dicarboxaldéhyde réagissent avec les chlorures et/ou bromures de cobalt(II), nickel(II), cuivre(It), zinc(II) et cadmium(It) pour conduire a diverses especes complexes. Les structures des ligands et des complexes ont é fé déterminées principalement par cristallographie et par spectroscopie infrarouge. Leurs propriétes antifongiques ont été testées vis a vis de trois souches : Candida albicans et glabrata et Aspergillus fumigatus<br>The thiophene - 3 -carboxaldehyde and thiophene-2,3

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8

Puthucode, Ramanan Narayan. "Design and synthesis of some aryloxyaryl semicarbazones and related compounds as novel anticonvulsants." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24036.pdf.

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9

Skamarauskas, John Timothy. "The role of semicarbazide-sensitive amine oxidase in the formation of toxic aldehydes." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621595.

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10

Assumpcao, Gioconda Alves de. "Ensaio pré-clínico do composto anticonvulsivante bromo-benzaldeído semicarbazona em ratos e cães." Universidade Federal de Minas Gerais, 2007. http://hdl.handle.net/1843/MCSC-7C6SVA.

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Despite the availability of wide range of anticonvulsant drugs, at least 25% of patients continue to have seizures. Furthermore, among those in whom seizures are effectively inhibited, substantial number of patients experience persistent and undesirable effects of these drugs. BrBS is a semicarbazone compound that has shown to possess excellent anticonvulsant activity in rats, besides their low or absent neurotoxicity. The objective of this present study was examine the ability of BrBS to prevent audiogenic seizures (AS) in Wistar Audiogenic Rats (WAR) and seizures induced by Pentilenetetrazol

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11

Nordquist, Jenny. "Semicarbazide-sensitive amine oxidase and vascular complications in diabetes mellitus : Biochemical and molecular aspects." Doctoral thesis, Uppsala University, Pharmacology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2566.

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<p>Plasma activity of the enzyme semicarbazide-sensitive amine oxidase (SSAO; EC.1.4.3.6) has been reported to be high in disorders such as diabetes mellitus, chronic congestive heart failure and liver cirrhosis. Little is known of how the activity is regulated and, consequently, the cause for these findings is not well understood. Due to the early occurrence of increased enzyme activity in diabetes, in conjunction with the production of highly cytotoxic substances in SSAO-catalysed reactions, it has been speculated that there could be a causal relationship between high SSAO activity and vascu

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12

Holt, Andrew. "Interactions of procarbazine and its metabolites with semicarbazide-sensitive amine oxidase : characterisation and consequences." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284094.

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13

黃友民 and Youmin Huang. "NMR spectroscopic and kinetic studies on secondary enamines of heterocyclic oximes hydrazones and semicarbazones." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1991. http://hub.hku.hk/bib/B31232243.

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14

Claud, Philippe. "Implication de la Semicarbazide-Sensitive-Amine-Oxydase dans le métabolisme d'une nouvelle entité chimique." Dijon, 2001. http://www.theses.fr/2001DIJOPE05.

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Le métabolisme du trespérimus, nouvel agent immunosuppresseur de la classe des polyamines, a été étudié chez l'homme et chez le rat. Le médicament est éliminé par un intense métabolisme non hépatique. Des études in vivo chez le rat et chez l'homme, combinant des analyses radio-HPLC et LC/MS, ont permis d'identifier deux voies de biotransformation. La principale voie métabolique du médicament concerne les désaminations oxydatives de sa moitié spermidine, particulièrement chez l'homme. L'autre route catabolique initiée par une réaction d'hydrolyse semble également impliquer une réaction de désam

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15

Bonaiuto, Emanuela. "Ammino Ossidasi umana sensibile alla semicarbazide: dalla caratterizzazione cinetica agli studi cellulari in adipociti." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426068.

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Human Semicarbazide-Sensitive Amine Oxidase (SSAO/VAP-1) is a transmembrane glycoprotein, which catalyzes the oxidative deammination of primary amines to aldehydes, with the release of the ammonium ion and hydrogen peroxide. The physiological role of SSAO/VAP-1 is not still clear: in adipocytes, SSAO/VAP-1 activity has an “insuline” like effect, while in vascular and sinusoidal hepatic endothelium, SSAO/VAP-1 is involved in the leucocyte extravasation at sites of inflammation. On these basis, the development of new specific inhibitors for SSAO/VAP-1 is an important target for the development o

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16

Christophe, du Barriere Mendes Charles. "Síntese e avaliação das atividades antinociceptiva e antichagásica de hidrazonas e semicarbazona derivadas do novo heterociclo pirrolidina[1,2-d][1,2,4]-2- oxadiazolina." Universidade Federal de Pernambuco, 2010. https://repositorio.ufpe.br/handle/123456789/2923.

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Made available in DSpace on 2014-06-12T16:24:59Z (GMT). No. of bitstreams: 2 arquivo1093_1.pdf: 3328003 bytes, checksum: 7ec0eb754a46ccba221bbd5d6ab76f03 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2010<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>A Química Medicinal, uma interseção da Química e da Farmacologia, envolve a identificação, síntese e desenvolvimento de novas entidades químicas destinadas ao uso terapêutico. A conjugação de características estruturais de duas ou mais classes distintas de compostos em

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Dutra, Jocely de Lucena. "Complexos de manganês com tiossemicarbazonas e semicarbazonas: obtenção e avaliação de atividade anti-Mycobacterium tuberculosis e citotoxicidade frente a linhagens celulares de tumor de mama humano e adenocarcinoma de pulmão humano." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-24072018-170903/.

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Oito complexos de manganês foram sintetizados com as tiossemicarbazonas ou semicarbazonas: salicilaldeído-4(N)-fenil-3-tiossemicarbazona (H2SAL-Phtsc), salicilaldeído-4(N)-metil-3-tiosemicarbazona (H2SAL-Metsc), salicilaldeído semicarbazona (H2SAL-Hsc), 2-hidroxiacetofenona semicarbazona (H2HAC-Hsc), salicilaldeído-4(N)-fenil-3-semicarbazona (H2SAL-Phsc) e 2-hidroxiacetofenona-4(N)-fenil-3-semicarbazona (H2HAC-Phsc). Estes agentes complexantes foram caracterizados por: ponto de fusão; RMN de 1H; análise elementar de C, H, N e S; difração de raios X em monocristal; espectroscopia de absorção no

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18

Prado, Viviana da Silva. "Obtenção de complexos de GaIII e InIII com interesse em medicina nuclear a partir do desenvolvimento de ligantes multidentados." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-16012018-103738/.

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Essa tese consiste na preparação de novos compostos de coordenação de Re, Ga e In como potenciais agentes de diagnóstico. Para a síntese desses complexos, foram propostos novos ligantes tiossemicarbazonas, semicarbazonas e iminas derivadas do 2-hidroxi-3-clorometil-5-metilbenzaldeído, o qual foi preparado a partir do reagente comercial 2,6-bis(hidroximetil)-4-metilfenol com rendimento de 76% após três etapas. Os novos ligantes foram obtidos em duas etapas, N-alquilação e condensação, com rendimentos médios de 60 a 75%, respectivamente. Foram obtidos ligantes tridentados, pentadentados e hexad

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19

Jakobsson, Emma. "Structural Studies of Echinococcus granulosus Fatty-acid-binding Protein 1 and Human Semicarbazide-sensitive Amine Oxidase." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis: Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5884.

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20

Scotti, Marcus Tullius. "Estudo de propriedades físico-químicas e de critérios para obtenção e validação de modelos QSAR para séries de análogos de semicarbazonas com atividade antichagásica, retiradas da literatura." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-01032007-112133/.

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O desenvolvimento tecnológico observado nos últimos anos e o avanço na aquisição de dados para os sistemas tanto químicos como biológicos tem gerado um grande número de informações. Como consequência, nos últimos anos, procuram-se ferramentas, fundamentalmente matemáticas, que permitam decodificar este volume imenso de informações, em termos estruturais e biológicos. Embora diversos parâmetros estatísticos e métodos de seleção de modelos e de variáveis tenham sido descritos, mais recentemente, são encontradas propostas de novas ferramentas visando assegurar tanto a qualidade de predição do mo

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21

Mercier, Nathalie. "Expression, régulation et fonctions de la "semicarbazide-sensitive amine oxidase" (SSAO) dans le tissu adipeux et la paroi vasculaire." Paris 6, 2003. http://www.theses.fr/2003PA066218.

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22

Norqvist-Sjöberg, Astrid. "Amine oxidases in dental pulp : a study with special regard to a semicarbazide-sensitive amine oxidase with catalytic potency towards serotonin." Doctoral thesis, Umeå universitet, Farmakologi, 1988. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-99295.

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The amine oxidizing capacity of piglet dental pulp tissue has been investigated. At least six separate enzyme activities could be distinguished: - a soluble semicarbazide-sensitive (SSAO) activity towards benzylamine, most likely to be derived from the content of blood plasma within the pulp tissue; - a soluble pulp tissue SSAO activity with most properties in common with the plasma enzyme, however with great efficiency not only regarding benzylamine but also tryptamine; - a tissue bound SSAO activity with activity towards benzylamine, tryptamine, tyramine and ß-phenylethylamine; - a tissue bo

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Norqvist-Sjöberg, Astrid. "Amine oxidases in dental pulp a study with special regard to a semicarbazide-sensitive amine oxidase with catalytic potency towards serotonin /." Umeå, Sweden : University of Umeå, 1988. http://catalog.hathitrust.org/api/volumes/oclc/18171069.html.

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Martins, Táric Ramon Marques. "Síntese, caracterização e avaliação da atividade biológica de ligantes orgânicos da classe das tiossemicarbazonas, semicarbazonas e hidrazonas." Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/7762.

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Steelman, David K. "Coordinative binding ability of a newly synthesized series of phenanthrolinedione semicarbazone and thiosemicarbazones a thesis presented to the faculty of the Graduate School, Tennessee Technological University /." Click to access online, 2009. http://proquest.umi.com/pqdweb?index=17&did=1913184211&SrchMode=1&sid=3&Fmt=6&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1264691946&clientId=28564.

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Martins, Tracy Martina Marques. "Síntese e caracterização de ligantes orgânicos e complexos metálicos com potencial farmacológico." Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/7718.

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Göktürk, Camilla. "Semicarbazide-sensitive Amine Oxidase (SSAO) – Regulation and Involvement in Blood Vessel Damage with Special Regard to Diabetes : A Study on Mice Overexpressing Human SSAO." Doctoral thesis, Uppsala University, Department of Neuroscience, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4673.

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<p>Semicarbazide-sensitive amine oxidase (SSAO, EC 1.4.3.6) belongs to a family of copper-containing amine oxidases. SSAO exists as a membrane bound protein in endothelial-, smooth muscle-, and adipose cells as well as soluble in plasma. SSAO catalyses oxidative deamination of primary monoamines, which results in the production of corresponding aldehydes, hydrogen peroxide and ammonia. These compounds are very reactive and potentially cytotoxic, and are able to induce vascular damage if produced in high levels. Patients with diabetes mellitus, and with diabetic complications in particular, hav

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Holfelder, Christina Ingrid. "Effects of the glutamic acid decarboxylase (GAD) inhibitor semicarbazide and anti-GAD autoantibodies-containing immunoglobulin G on neuronal network activity within the motor cortex." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-123547.

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Göktürk, Camilla. "Semicarbazide-sensitive amine oxidase (SSAO) - regulation and involvement in blood vessel damage with special regard to diabetes : a study on mice overexpressing human SSAO /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4673.

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Vital, Drielli Gomes. "Planejamento, síntese e avaliação biológica de análogos bioisostéricos da nitrofurazona: variações de anéis (pirrol e 4-dimetilaminobenzil) e cadeias laterais (semicarbazona, tiossemicarbazona e aminoguanidina)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-27022014-104638/.

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A doença de Chagas é uma infecção causada pelo protozoário intracelular Trypanosoma cruzi. Atualmente 7 a 8 milhões de pessoas encontram-se infectadas, e há 25 milhões de pessoas em áreas de risco de contaminação. A cada ano ocorrem 56.000 novos casos e, aproximadamente, 12.000 mortes por complicações oriundas da doença. É endêmica em 21 países da América do Sul, e pode ser encontrada, também, na América do Norte e Europa devido a processos migratórios. Somente dois fármacos estão disponíveis para o tratamento da doença de Chagas, o nifurtimox e o benznidazol, que são ativos somente na fase ag

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CAMPANA, MIREILLE. "Synthese de nouvelles semicarbazones et thiosemicarbazones d'esters et d'amides. Etude toxicologique liee a leur complexation par l'ion zinc, in vitro, sur les ilots de langerhans." Paris 7, 1991. http://www.theses.fr/1991PA077111.

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Les thiosemicarbazones sont des chelateurs de l'ion zinc. Cet ion joue un role important dans le biosynthese de l'insuline et dans le stockage de l'insuline et du glucagon. Les travaux presentes dans cette these ont eu pour but d'etudier l'action de derives originaux de la thiosemicarbazide et de quelques homologues, sur les cellules des ilots de langerhans. La premier partie concerne la synthese chimique de thiosemicarbazones d'esters (sept) et d'amides (quatorze) et de treize semicarbazones homologues. De nombreuses reactions ont ete etudiees dont certaines etaient originales. Les caracteris

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Sonja, Ivković. "Novi kompleksi nekih 3d metala sa semi-, tiosemi- i S-metilizotiosemikarbazonom piridoksala." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2014. https://www.cris.uns.ac.rs/record.jsf?recordId=85689&source=NDLTD&language=en.

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Opisane su sinteze, fizičko-hemijske i strukturne karakteristike kompleksa Cu(II), Co(II), Co(III), Ni(II), Fe(III), Cr(III) Zn(II) i Cd(II) sa PLSC, PLTSC i PLITSC. Dobijene su dve nove protonovane forme liganda PLSC, kao i od ranije poznati neutralna forma PLSC i protonovana forma PLTSC ali u vidu monokristala pogodnih za rentgeno-strukturnu analizu i 37 kompleksa, od čega je 12 okarakterisano rentgeno-strukturnom analizom. U zavisnosti od pH sva tri liganda se mogu koordinovati kao neutralni, mono-, odnosno, dianjoni sa uobičajenim ONO, ONS i ONN setom donorskih atoma, respektivno, pri čemu

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Filip, Anna. "La semicarbazide-sensitive amine oxydase : son rôle dans la différenciation cellulaire des chondrocytes et des cellules musculaires lisses vasculaires et son implication dans des pathologies articulaires et cardiovasculaires." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0244/document.

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La « semicarbazide-sensitive amine oxidase » (SSAO) catalyse la déamination oxydative des amines primaires en aldéhyde, peroxyde d’hydrogène et ammoniac. Elle participe à la différenciation cellulaires, l’inflammation et la transmigration leucocytaire à travers l’endothélium lymphatique. Nos objectifs ont été d’étudier le rôle de la SSAO (i) dans la différenciation chondrocytaire hypertrophique, en relation avec le développement de l’arthrose en utilisant des chondrocytes de rat en culture primaire et des genoux arthrosiques de patients (ii) dans le développement de l’athérosclérose en invalid

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Reimer, Adriano Edgar. "Envolvimento de mecanismos GABAérgicos da substância cinzenta periaquedutal dorsal e do colículo inferior no medo condicionado e incondicionado." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/59/59134/tde-08092013-014529/.

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A substância cinzenta periaquedutal dorsal (SCPd) e o colículo inferior (CI) são duas estruturas do teto mesencefálico que, juntamente com a amígdala, o hipotálamo dorsomedial e o colículo superior, estão envolvidas na modulação da expressão comportamental dos estados de medo. A estimulação química ou elétrica destas estruturas produz uma série de respostas comportamentais defensivas. Além disso, dados comportamentais com modelos animais de ansiedade têm fornecido evidências da existência de uma regulação inibitória tônica GABAérgica na SCPd e CI. Neste estudo investigamos o envolvimento da ne

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Nguyen, Thu Huong. "Nouvelles méthodes de synthèse des dihydro -2,4 triazol -1,2,4 ones -3 trisubstituées en positions 2,4 et 5 à partir de semicarbazones disubstituées en positions 2 et 4 d’aldéhydes aromatiques : étude de leurs propriétés antibactérienne, antiparasitaire et herbicide (euglène gracile)." Paris 7, 1985. http://www.theses.fr/1985PA07F133.

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De nouvelles semicarbazones 2,4 disubstituées dont certaines portent un groupe nitro -5 furyle -2 ont été synthétisées. L’emploi de nouveaux oxydants, le bioxyde de plomb et le monochlorure de soufre, ont permis de les cycliser en dérivés dihydro -2,4 triazol -1,2,4 ones –3 correspondantes. Des mécanismes réactionnels ont été proposés. D'autres réactions de ces oxydants sont présentés. Des tests antibactériens ont été effectués sur E. Coli, S. Aureus et C. Albicans. Les propriétés antiparasitaires ont été étudiées sur Entamoeba Histolytica, Trichomonas vaginalis et Trypanosoma Brucei. L’activi

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Sibon, Igor. "Implication des amines oxydases dans l'organisation et le maintien de l'intégrité de la structure de la lame élastique artérielle : comparaison de la distribution et de l'activité de la Semicarbazine Sensitive Amine Oxydase et de la Lysyl Oxydase dans des modèles humains et animaux d'anévrysmes et d'hypertension artérielle." Bordeaux 2, 2004. http://www.theses.fr/2004BOR21116.

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La fibre élastique est un des composants majeurs de la paroi artérielle. Elle est impliquée dans la flexibilité et la distensibilité de l'artère. La polymérisation de l'élastine et les interactions des microfibrilles et de l'élastine sont des étapes clés de l'organisation de la fibre élastique. De nombreux travaux ont mis en évidence le rôle des amineoxydases, parmi lesquelles la lysyl oxydase dans la formation des cross-links entre les composants de la fibre élastique. L'objectif de ce travail fut de comparer, au travers de différents modèles pathologiques chez l'homme et chez l'animal, l'inf

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Levinsson, Jennie. "Semicarbazide-sensitive amine oxidase (SSAO) activity assay in plasma samples." Thesis, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-205219.

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Varsha, Kiran. "Some synthetically useful reactions of hydrazones,semicarbazones and cyclic imides." Thesis, 1992. http://localhost:8080/iit/handle/2074/3515.

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Chingle, Ramesh. "Design, synthesis, pericyclic chemistry and biomedical applications of azopeptides." Thèse, 2018. http://hdl.handle.net/1866/20753.

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Teng, Kai-teng, and 鄧凱騰. "Studies on the reactions of CuCl2 (II) with diversecarbazides、carbazones and semicarbazones." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/59945132708216095621.

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碩士<br>南台科技大學<br>化學工程與材枓工程系<br>98<br>α-Chloroformylarylhydrazine contains two different functional groups. One is the strong nucleophile, and the other is a good electrophile. Therefore, it can react with several reagents to obtain diverse derivatives, which can be used as ligands for metal complexes. With the aim of obtaining new biological active compounds, this study addresses on the syntheses of novel chelating ligands and metal complexes. The text is divided into three major parts. In the first part, many kinds of aldehyde 2,5-diaryl-substituted-carbazones were successfully synthesized. α-

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Teng, Kai-Teng, and 鄧凱騰. "Studies on the reactions of CuCl2 (II) with diverse carbazides、carbazones and semicarbazones." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/18197305001943487543.

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碩士<br>南台科技大學<br>化學工程與材枓工程系<br>98<br>α-Chloroformylarylhydrazine contains two different functional groups. One is the strong nucleophile, and the other is a good electrophile. Therefore, it can react with several reagents to obtain diverse derivatives, which can be used as ligands for metal complexes. With the aim of obtaining new biological active compounds, this study addresses on the syntheses of novel chelating ligands and metal complexes. The text is divided into three major parts. In the first part, many kinds of aldehyde 2,5-diaryl-substituted-carbazones were successfully synthesized. α-

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Lin, Tzu-Ting, and 林姿婷. "Studies on the syntheses and coordination of transition metal complexes with diverse tetradentate、bis-thridentate semicarbazone ligands." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/93356062228091025176.

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碩士<br>南台科技大學<br>化學工程與材枓工程系<br>98<br>α-Chloroformylarylhydrazine contains two different functional groups. One is the strong nucleophile, and the other is a good electrophile. Therefore, it can react with several reagents to obtain diverse derivatives, which can be used as ligands for metal complexes. With the aim of obtaining new biological active compounds, this study addresses on the syntheses of novel chelating tetradentate ligands、bis-tridentate ligands and the corresponding transition metal complexes. The text is divided into three major parts. In the first part, various salicyaldehyde 2

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Noppeney, Yvonne Maria Laurentia [Verfasser]. "Semicarbazide organogels containing inorganic nanoparticles : new supramer particle hybrid systems / vorgelegt von Yvonne Maria Laurentia Noppeney." 2009. http://d-nb.info/995596107/34.

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陳光伯. "Studies on the Synthese of Derivatives of 3-Aryl-4-Formylsydnone Semicarbazones and Their Cyclization Reactions." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/89778527850708521163.

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碩士<br>國立成功大學<br>化學系<br>89<br>The reactivity of sydnones is different from normal compounds as a result of their peculiar distribution of electrons. Fur- thermore,sydnones and some heterocyclic compounds may possess biological and pharmacological activities.If some functional groups were introduced to fourth position of sydnone ring to form the precursors of the heterocyclic substituents,via cyclization, 3-aryl-4-(heterocycle-substituted)sydnones.It is possible that some biological and pharmacological activities could be obtained. In this study,3-aryl-4-formylsydnone guan

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MacKenzie, Erin Margaret. "Neurochemical and neuroprotective aspects of phenelzine and its active metabolite B-phenylethylidenehydrazine." Phd thesis, 2009. http://hdl.handle.net/10048/721.

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Phenelzine (PLZ) is a monoamine oxidase (MAO) inhibitor that also inhibits the activity of GABA-transaminase (GABA-T), causing significant and long-lasting increases in brain GABA levels. Inhibition of MAO prior to PLZ administration has been shown to prevent the GABAergic effects of the drug, strongly suggesting that a metabolite of PLZ formed by the action of MAO is responsible for the GABAergic effects. While PLZ has been used clinically for decades for its antidepressant and antipanic effects, it has more recently been shown to be neuroprotective in an animal model of ischemia. The aim of

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Lin, Yin-Shiou, and 林音秀. "Monohydroxamates of Aspartic Acid and Glutamic Acid Exhibit Antioxidant and Inhibitory Activities against Angiotensin Converting Enzyme and Semicarbazide - Sensitive Amine Oxidase." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/76035709378980451191.

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碩士<br>臺北醫學大學<br>生藥學研究所<br>93<br>The antioxidant activities and inhibitory activities against angiotensin converting enzyme (ACE) and semicarbazide-sensitive amine oxidase of monohydroxamates of aspartic acid and glutamic acid (L-aspartic acid -hydroxamate, AAH; L-glutamic acid -hydroxamate, GAH) were investigated in this thesis.. From the results of DPPH scavenging activities, it was found that both AAH and GAH exhibited dose-dependent scavenging activities, and the IC50 was 36 M and 48 M, respectively. For superoxide radical scavenging activities by the NADH-PMS generating system, the IC5

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Lu, Yeh-Lin, and 呂岳霖. "Study on The Biological Activities of Different Species from Momordica charantia L. var. abbreviata Seringe: Antioxidation, Antibacteria, Cytotoxicity and Inhibition of Semicarbazide-Sensitive Amine Oxidase Activity." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/17340442739235789991.

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碩士<br>臺北醫學大學<br>生藥學研究所<br>94<br>The water or methanol extracts from sixteen species of Momordica charantia L. var. abbreviata Seringe (MCs) were used for anti-oxidation, cytotoxicity, anti-bacteria and SSAO inhibition screening assays. It was found that the variations among the species of each biological activity were found. For screening of the anti-oxidation activity, the IC50 for the most potent species on DPPH scavenging activity assay was 181 g/mL equivalent to 25.500 g of Trolox® per gram water extracts. For screening of superoxide radical scavenging activity using autoxidation of pyro

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Holfelder, Christina Ingrid [Verfasser]. "Effects of the glutamic acid decarboxylase (GAD) inhibitor semicarbazide and anti-GAD autoantibodies-containing immunoglobulin G on neuronal network activity within the motor cortex / vorgelegt von Christina Ingrid Holfelder." 2010. http://d-nb.info/1009568817/34.

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Poupart, Julien. "Synthesis, diversification and biomedical applications of 4,5-substitued N-aminoimidazol-2-ones." Thesis, 2020. http://hdl.handle.net/1866/24770.

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In peptide-based medicinal chemistry, mimicry of turn conformations is important because of the significance of such secondary structures for molecular recognition. In this context, N-aminoimidazol-2-one (Nai) residues have demonstrated ability to mimic the central residue of turn conformers. Moreover, potential to functionalize the 4- and 5-positions of the Nai heterocycle offer opportunities to add and orient side chain functionalities with constrained c-geometry. Methods have been developed to employ Nai residues for peptide mimicry. Previously, Nai dipeptide esters with substituents at

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Proulx, Caroline. "Méthodologie pour la synthèse combinatoire d’azapeptides: application à la synthèse d’analogues aza-GHRP-6 en tant que ligands du récepteur CD36." Thèse, 2012. http://hdl.handle.net/1866/8887.

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Les azapeptides sont des mimes peptidiques où le carbone alpha d’un ou de plusieurs acides aminés est remplacé par un atome d’azote. Cette modification tend à stabiliser une conformation en repliement beta en raison de la répulsion électronique entre les paires d’électrons libres des atomes d’azote adjacents et de la géométrie plane de l’urée. De plus, le résidu semicarbazide a une meilleure résistance face aux protéases en plus d’être chimiquement plus stable qu’une liaison amide. Bien que les propriétés des azapeptides en fassent des mimes peptidiques intéressants, leurs méthodes de synthèse

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