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Journal articles on the topic 'Semicarbazoue'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Garg, Ajay kumar. "Screening of semicarbazones as anticonvulsant agents." Medicinal Chemistry 11, no. 10 (2021): 6. https://doi.org/10.5281/zenodo.10669307.

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The principal objective of the present investigation was the preparation of several analogs to further evaluate the binding site hypothesis. Aryl semicarbazides have also been reported to display excellent anticonvulsant activity in mice and rats. Method: In this project, the synthesis of semicarbazone derivatives was carried out. All molecules were synthesized using the common starting material –aniline. In all compounds, an intermediate was first formed by substituted phenyl urea using substituted aniline and potassium cyanate, and then it was hydrolyzed to get substituted phenyl semic

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2

P., Saritha Reddy, Satyanarayana B., and Jayatyagaraju. "Synthesis and structural studies on divalent transition metal complexes of 5-acetyl 2,4-dihydroxy acetophenone semicarbazone." Journal of Indian Chemical Society Vol. 83, Dec 2006 (2006): 1204–7. https://doi.org/10.5281/zenodo.5833184.

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Department of Chemistry, Osmania University College for Women, Osmania University, Hyderabad-500 095, India <em>E-mail </em>: abbareddysaritha@hotmail.com Department of Chemistry, University College of Engineering, Osmania University, Hyderabad-500 007, India   <em>E-mail</em> : satyambchem@yahoo. co .in; narayana satya 1969@yahoo .co. in   <em>Manuscript received 5 July 2006, revised 5 September 2006, accepted 5 September 2006</em> The synthesis of divalent transition metal complexes of a new dibasic, bis-chelating ligand 5-acetyl 2,4 dihydroxy acetophenone semicarbazone (H<sub>2</s

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3

Silva, Bianca N. M., Policarpo A. Sales Junior, Alvaro J. Romanha, et al. "Synthesis of New Thiosemicarbazones and Semicarbazones Containing the 1,2,3-1H-triazole-isatin Scaffold: Trypanocidal, Cytotoxicity, Electrochemical Assays, and Molecular Docking." Medicinal Chemistry 15, no. 3 (2019): 240–56. http://dx.doi.org/10.2174/1573406414666180912120502.

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Background: Chagas disease, also known as American trypanosomiasis, is classified as one of the 17 most important neglected diseases by the World Health Organization. The only drugs with proven efficacy against Chagas disease are benznidazole and nifurtimox, however both show adverse effects, poor clinical efficacy, and development of resistance. For these reasons, the search for new effective chemical entities is a challenge to research groups and the pharmaceutical industry. Objective: Synthesis and evaluation of antitrypanosomal activities of a series of thiosemicarbazones and semicarbazone

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4

Fesenko, Anastasia A., Ludmila A. Trafimova, Maxim O. Zimin, Alexander S. Kuvakin, and Anatoly D. Shutalev. "A New Efficient Route to 2-Alkylsemicarbazides." Proceedings 41, no. 1 (2019): 46. http://dx.doi.org/10.3390/ecsoc-23-06501.

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Synthesis of hardly available 2-alkylsemicarbazides and their hydrochlorides from semicarbazide hydrochloride has been developed. This general and efficient protocol is based on preparation of acetone semicarbazone, its N2-alkylation in the presence of sodium hydride, and hydrolysis under mild conditions.

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5

Ashok, N. Patange*1 Ramesh G.Paloti2 Ramesh N.Zade3 Kushal M.Mude4 &. Bhupesh M.Mude5. "DESIGN, SYNTHESIS AND CHARACTERISATION OF SOME SEMICARBAZONE AND THIOSEMICARBAZONE DERIVED FROM 3-PHENYLQUINAZOLINE-2, 4(1H, 3H)-DIONE." GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES 5, no. 4 (2018): 10–14. https://doi.org/10.5281/zenodo.1211485.

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This paper presents the synthesis and characterizations of some semicarbazone and thiosemicarbazone derivatives of3-phenylquinazoline-2,4(1H,3H)-dione. All compounds reported here had been characterised by<sup>1</sup>H NMR and IR spectral studies and elemental analysis. semicarbazone and thiosemicarbazone derivatives of 3-phenylquinazoline-2,4(1H,3H)-dionewere prepared by treating mixture of phenyl isocyanates and anthanilic acid in ethanol to get 3-phenylquinazoline-2,4(1H,3H)-dionewhich will then condense with substituted4-chloro/bromo/iodoAcetophenones in ethanolto form the chalcones .this

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6

Tatarinova, I. V., N. A. Lobanova, I. A. Ushakov, E. Yu Schmidt, and B. A. Trofimov. "Semicarbazones of acetyldihydropyrans: diastereoselective acetylene-based two-step synthesis." Журнал органической химии 59, no. 3 (2023): 405–10. http://dx.doi.org/10.31857/s0514749223030126.

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2-Acetyl-3,4-dihydropyrans (diastereoselectively synthesized from acetylene and aromatic ketones in a one synthetic operation) reacted with semicarbazide hydrochloride to stereoselectively form semicarbazones of E -configuration in up to 86% yield.

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7

D., M. PATEL, M. PATEL M. та R. PATEL M. "α-Oximino-β-semicarbazones of Benzoylacetarylamides and Their Cyclisation to vicinal-Triazoles". Journal of Indian Chemical Society Vol. 62, Aug 1985 (1985): 604–6. https://doi.org/10.5281/zenodo.6321604.

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Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar-388 190 Manuscript <em>received 4 August 1984, accepted 27 April 1986</em> Seven α-oximino-β-semicarbazones of benzoylacetarylamides have been prepared by condensing semicarbazide and α-oximinobenzoylacetarylamides. α-Oximino-β-semicarbazones of benzoylacetarylamides were cyclised in thionyl chloride or acetic anhydride/sodium acetate to give 2-carbamido-5-carboxyarylamino-4-phenyl-1,2,3-triazoles. The<em> </em>compounds synthesised were characterised by elemental analysis, uv and it spectra.

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8

Nath Pandeya, Surendra. "Semicarbazone – a versatile therapeutic pharmacophore for fragment based anticonvulsant drug design." Acta Pharmaceutica 62, no. 3 (2012): 263–86. http://dx.doi.org/10.2478/v10007-012-0030-1.

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During the last fifteen years, semicarbazones have been extensively investigated for their anticonvulsant properties. 4-(4-Flurophenoxy) benzaldehyde semicarbazone (C0102862, V102862) was discovered as a lead molecule and is being developed as a potent antiepileptic drug, with maximal electroshock (MES) ED50 of i.p. 12.9 mg kg-1. In MES (oral screen), this compound has a protective index (PI = TD50/ED50 > 315) higher than carbamazepine (PI 101), phenytoin (PI > 21.6) and valproate (PI 2.17). The compound is a potent sodium channel blocker. Other semicarbazones have demonstrated activity

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9

Inoue, Mayara Hissami, Davi F. Back, Robert A. Burrow, and Fábio Souza Nunes. "Crystal structure of 4-formylpyridine semicarbazone hemihydrate." Acta Crystallographica Section E Crystallographic Communications 71, no. 5 (2015): o317—o318. http://dx.doi.org/10.1107/s2056989015007276.

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The molecule of the title compound C7H8N4O·0.5H2O, alternatively called (E)-1-(pyridin-4-ylmethylene)semicarbazide hemihydrate, is in theEconformation and is almost planar; the r.m.s. deviation of the positions of the atoms of the pyridine ring from the best-fit plane is 0.0039 Å. The C, N and O atoms of the rest of the molecule sits close on this plane with a largest deviation of 0.115 (4) Å for the O atom of the semicarbazone moiety. There is an intramolecular N—H...N hydrogen bond. In the crystal, molecules are linked into an infinite three-dimensional network by classical N—H...Os(s = semi

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10

Sengupta, S. K., O. P. Pandey, G. P. Rao, and Priyanka Singh. "Efficacy of Organophosphorus Derivatives Containing Chalcones/Chalcone Semicarbazones Against Fungal Pathogens of Sugarcane." Metal-Based Drugs 8, no. 5 (2002): 293–302. http://dx.doi.org/10.1155/mbd.2002.293.

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Ten newly synthesized organophosphorus derivatives containing substituted chalcones and substituted chalcone semicarbazones were tested for their antifungal efficacy against Colletotrichum falcatum, Fusarium oxysporum, Curvularia pallescens (all sugarcane pathogens). The O,O-diethylphosphate derivatives containing 2-chlorochalcone and 2-chlorochalcone semicarbazone exhibited 70-85% mycelial inhibition against all the test fungi at 1000 ppm. The screening results were correlated with structural features of the tested compounds.

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11

Yadav, Vijay Kumar, Meena Bhandari, and Satbir Singh. "GREEN SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME THIOSEMICARBAZONE AND SEMICARBAZONE DERIVATIVES." RASAYAN Journal of Chemistry 17, no. 04 (2024): 1727–31. http://dx.doi.org/10.31788/rjc.2024.1748967.

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The interaction of substituted pyridine carboxaldehyde with thiosemicarbazide and semicarbazide via a greener approach resulted in the synthesis of thiosemicarbazone and semicarbazone derivatives; respectively. The resultant compounds were synthesized in aqueous media and were characterized by FTIR and 1H-NMR spectral studies. The antimicrobial evaluation of the final compounds has proven that they are active against the strains (S. aureus, P. aeruginosa, A. niger, and C. glabrata) incorporating the microdilution method.

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12

Yehye, Wageeh, and Amit Nath. "Acid Hydrazide: A Potential Reagent for the Synthesis of Semicarbazones." Synthesis 50, no. 21 (2018): 4301–12. http://dx.doi.org/10.1055/s-0037-1609557.

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Complex semicarbazone derivatives were successfully synthesized from substituted semicarbazides in acidic ethanol upon heating in the presence of aldehyde. The reaction is functional group tolerant and chemoselective because no terminal hydrazine moiety is present in the substituted semicarbazides. Thus, functional groups such as esters and acetyls, which are prone to reaction with hydrazine, can also be used in this reaction because the terminal hydrazine moiety of the acid hydrazide was protected by aryl isocyanates in order to prepare substituted semicarbazides. In addition, neither of the

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13

Agrawal, Prachi, and G. Jeyabalan. "Synthesis and antimicrobial activity of some newer semicarbazone analogues." Indian Journal of Pharmaceutical and Biological Research 5, no. 02 (2017): 12–17. http://dx.doi.org/10.30750/ijpbr.5.2.3.

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On the basis of literature review Semicarbazones have been potent in activities such as antifungal, antibacterial, antituberculosis, anticancerous etc. Till date various works has been done however still there is tremendous opportunities which can be explored. So, we planned for the synthesis of Semicarbazone derivaties and checking their antimicrobial activities. Biological activity was determined for all 19 synthesized compounds against bacteria (gram positive and gram negative) by MIC(Minimum Inhibitory Concentration) method.

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14

Vald�s-Mart�nez, Jes�s, Ruben A. Toscano, Roberto Salcedo, Raymundo Cea-Olivares, and Adrian Mel�ndez. "Semicarbazones and thiosemicarbazones, XII: Crystal structure of salicylaldehyde semicarbazone." Monatshefte f�r Chemie Chemical Monthly 121, no. 8-9 (1990): 641–47. http://dx.doi.org/10.1007/bf00809767.

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15

Sinha, Navneet, Rajnish Kumar, Vijay Pratap Singh, Deepak KUMAR, and Shivadhar Sharma. "Spectroscopic Elucidation of Some Complexes of Vanillin Semicarbazone." Oriental Journal Of Chemistry 37, no. 4 (2021): 826–32. http://dx.doi.org/10.13005/ojc/370409.

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3-Phenyl-4-methoxybenzaldehyde undergoes condensation with semicarbazide hydrochloride to form a Schiff-base i.e. 3-phenyl-4-methoxybenzaldehyde semicarbazone (abbreviated as MBS). It undergoes complexation with Vanadium(II), Manganese(II), and Copper(II). The comparison of FTIR-spectra of complexes with that of free ligand helps ascertain the coordination points of ligand through the nitrogen of –CH=N– group and oxygen of group. The axial ligands have been varied by chloride, acetate and nitrate ions. The UV/Visible and ESR spectra of complexes predicts their tetragonally distorted octahedral

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16

Arfan, Atef, and Mwaffak Rukiah. "Crystal structures of crotonaldehyde semicarbazone and crotonaldehyde thiosemicarbazone from X-ray powder diffraction data." Acta Crystallographica Section E Crystallographic Communications 71, no. 2 (2015): 168–72. http://dx.doi.org/10.1107/s2056989015000663.

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Crotonaldehyde semicarbazone {systematic name: (E)-2-[(E)-but-2-en-1-ylidene]hydrazinecarboxamide}, C5H9N3O, (I), and crotonaldehyde thiosemicarbazone {systematic name: (E)-2-[(E)-but-2-en-1-yldene]hydrazinecarbothioamide}, C5H9N3S, (II), show the sameEconformation around the imine C=N bond. Compounds (I) and (II) were obtained by the condensation of crotonaldehyde with semicarbazide hydrochloride and thiosemicarbazide, respectively. Each molecule has an intramolecular N—H...N hydrogen bond, which generates anS(5) ring. In (I), the crotonaldehyde fragment is twisted by 2.59 (5)° from the semic

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17

Kuevi, Urbain A., Gaston A. Kpotin, Guy S. Y. Atohoun, and Jean-Baptiste Mensah. "Theoretical Study of the Coordination of Semicarbazone and Its Methylated Derivatives." International Journal of Chemistry 10, no. 1 (2018): 1. http://dx.doi.org/10.5539/ijc.v10n1p1.

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Semicarbazone is a molecule with a group R1R2C=N-NR3-C(=O)-NR4R5.The oxygen atom has two free electron pairs; each nitrogen atom has one free electron pair. These free electron pairs are potential sites of coordination. The simplest molecule in this series is the semicarbazone which the formula is H2C=N-NH-C(=O)NH2. By replacing the oxygen atom by a sulfur atom is obtained a thiosemicarbazone. Some semicarbazones, such as nitrofurazone, and some thiosemicarbazones are known to have many properties: antiviral, antibacterial, antitrypanosomal, anticonvulsant, antitumor, anticancer. They are usua

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18

Abernethy, Grant, and Kerianne Higgs. "Lactose semicarbazone as a marker for semicarbazide adulteration in milk." Journal of Chromatography A 1295 (June 2013): 152–55. http://dx.doi.org/10.1016/j.chroma.2013.03.075.

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19

Govindasamy, Rathika, Sathiyapriya Thirumalaisamy, Kohila chandran, Manikandan Dhayalan, and Mika Sillanpaa. "Improved corrosion inhibition by heterocyclic compounds on mild steel in acid medium." Corrosion Reviews 40, no. 2 (2022): 137–48. http://dx.doi.org/10.1515/corrrev-2021-0045.

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Abstract A detailed comparative study on inhibitive behaviour against corrosion of mild steel in 1N H2SO4 IN HCl for the Schiff bases 2,6-diphenyl-3-methyl azinan-4-one (D3MA) (S1), 2,6-diphenyl-3-methyl azinan-4-one semicarbazone (D3MAS) (S2), 2,6-diphenyl azinan-4-one (DA) (S3) and 2,6-diphenylazinan-4-one semicarbazone (DAS) (S4) was investigated using gravimetric and potentiodynamic polarisation methods. The thermodynamic parameters for the mild steel corrosion and the synergistic behaviour of the inhibitors in the presence of anions and cations were determined and discussed. It was found

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20

Garcia-Ramos, Yesica, Caroline Proulx, and William D. Lubell. "Synthesis of hydrazine and azapeptide derivatives by alkylation of carbazates and semicarbazones." Canadian Journal of Chemistry 90, no. 11 (2012): 985–93. http://dx.doi.org/10.1139/v2012-070.

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Hydrazine and azapeptide analogs were synthesized effectively by alkylation of alkylidene carbazates and semicarbazones. In comparisons of benzylidene, benzhydrylidene, and fluorenylidene tert-butyl carbazates in alkylations using bases of different pKb character, superior conversion was obtained using the fluorenone derivative. Mild alkylation conditions were found employing Et4NOH as base and used to convert fluorenylidene tert-butyl carbazate into 13 different protected hydrazines. Moreover, racemization was avoided during alkylation of fluorenylidene semicarbazide in the synthesis of aza-p

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21

Sonawane, Ratnamala P. "Synthesis, Characterization and Antimicrobial Activity of 2-[1-(2,4-Dihydroxyphenyl)Ethylene]Hydrazine Carboxamide and its Zn(II) Metal Complex." International Letters of Chemistry, Physics and Astronomy 79 (August 2018): 9–16. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.79.9.

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The synthesis of 2-[1-(2,4- dihydroxyphenyl)ethylene]hydrazinecarboxamide and its Zn(II) metal complex was achieved. 2, 4 dihydroxy acetophenone is synthesized by resorcinol with glacial acetic acid. This further treated with semicarbazide hydrochloride to form its semicarbazone. Zn(II) metal complex was prepared by dissolving equimolar quantities of metal salt and Schiff base ligand in ethanol. All the target compounds were characterized by M.P, TLC and UV-visible and IR spectral data. Antimicrobial activities of these synthesized compounds were studied in sterile saline by Agar well diffusio

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22

Sonawane, Ratnamala P. "Synthesis, Characterization and Antimicrobial Activity of 2-[1-(2,4-Dihydroxyphenyl)Ethylene]Hydrazine Carboxamide and its Zn(II) Metal Complex." International Letters of Chemistry, Physics and Astronomy 79 (August 29, 2018): 9–16. http://dx.doi.org/10.56431/p-g62397.

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The synthesis of 2-[1-(2,4- dihydroxyphenyl)ethylene]hydrazinecarboxamide and its Zn(II) metal complex was achieved. 2, 4 dihydroxy acetophenone is synthesized by resorcinol with glacial acetic acid. This further treated with semicarbazide hydrochloride to form its semicarbazone. Zn(II) metal complex was prepared by dissolving equimolar quantities of metal salt and Schiff base ligand in ethanol. All the target compounds were characterized by M.P, TLC and UV-visible and IR spectral data. Antimicrobial activities of these synthesized compounds were studied in sterile saline by Agar well diffusio

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23

Rao, Nidagurthi Guggulla Raghavendra, Prashanti Chitrapu, Gurinderdeep Singh, Sowjanya Pulipati, and Hari Veluru. "Synthesis and in silico Assessment of Heteroaryl Semicarbazones: Towards Understanding Antimicrobial Activities and Safety Profiles." Asian Journal of Chemistry 36, no. 5 (2024): 1135–41. http://dx.doi.org/10.14233/ajchem.2024.31388.

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Seven semicarbazone derivatives incorporating either substituted furan or thiophene were synthesized by reacting phenylurea with semicarbazide and various heteroaryl aldehydes. The newly synthesized compounds were characterized using IR, NMR, mass spectrometry and elemental analysis. Additionally, their antibacterial and anti-tubercular activities were also evaluated. In silico tools such as Swiss ADME and Pro Tox II were employed to assess molecular targets, medicinal chemistry properties, as well as toxicity and safety profiles. Compounds 3a-g demonstrated significant antibacterial activity

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24

VALDES-MARTINEZ, J., R. A. TOSCANO, R. SALCEDO, R. CEA-OLIVARES, and A. MELENDEZ. "ChemInform Abstract: Semicarbazones and Thiosemicarbazones. Part 12. Crystal Structure of Salicylaldehyde Semicarbazone." ChemInform 22, no. 6 (2010): no. http://dx.doi.org/10.1002/chin.199106034.

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25

Dragancea, Diana, Ghenadie Novitchi, Augustin M. Mădălan, and Marius Andruh. "New Cyanido-Bridged Heterometallic 3d-4f 1D Coordination Polymers: Synthesis, Crystal Structures and Magnetic Properties." Magnetochemistry 7, no. 5 (2021): 57. http://dx.doi.org/10.3390/magnetochemistry7050057.

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Three new 1D cyanido-bridged 3d-4f coordination polymers, {[Gd(L)(H2O)2Fe(CN)6]·H2O}n (1GdFe), {[Dy(L)(H2O)2Fe(CN)6]·3H2O}n (2DyFe), and {[Dy(L)(H2O)2Co(CN)6]·H2O}n (3DyCo), were assembled following the building-block approach (L = pentadentate bis-semicarbazone ligand resulting from the condensation reaction between 2,6-diacetyl-pyridine and semicarbazide). The crystal structures consist of crenel-like LnIII-MIII alternate chains, with the LnIII ions connected by the hexacyanido metalloligands through two cis cyanido groups. The magnetic properties of the three complexes have been investigate

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26

Novaković, Sladjana B., Goran A. Bogdanović, Vukadin M. Leovac, Marko V. Rodić, Ljiljana S. Vojinović-Ješić, and Sonja Ivković. "(E)-4-[(2-Carbamoylhydrazinylidene)methyl]-3-hydroxy-5-hydroxymethyl-2-methylpyridin-1-ium nitrate." Acta Crystallographica Section C Crystal Structure Communications 69, no. 7 (2013): 761–64. http://dx.doi.org/10.1107/s0108270113013929.

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The title compound, C9H13N4O3+·NO3−, is the first structurally characterized Schiff base derived from semicarbazide and pyridoxal. Unusually for an unsubstituted semicarbazone, the compound adopts asynconformation, in which the carbonyl O atom is in acisdisposition relative to the azomethine N atom. This arrangement is supported by a pair of hydrogen bonds between the organic cation and the nitrate anion. The cation is essentially planar, with only a hydroxymethyl O atom deviating significantly from the mean plane of the remaining atoms (r.m.s. deviation of the remaining non-H atoms = 0.01 Å).

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27

Hanganu, Anamaria, Catalin Maxim, Andreea Dogaru, et al. "Synthesis, Physicochemical Properties, and Ion Recognition Ability of Azulene-Based Bis-(Thio)Semicarbazone." Molecules 30, no. 1 (2024): 83. https://doi.org/10.3390/molecules30010083.

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Azulene-1,3-bis(semicarbazone), 1, and azulene-1,3-bis(thiosemicarbazone), 2, were synthesized by the acid-catalyzed condensation reactions of semicarbazide and thiosemicarbazide, respectively, with azulene-1,3-dicarboxaldehyde in stoichiometric amounts. Compounds 1 and 2 were identified by high-resolution mass spectrometry and characterized by IR, 1H-NMR, 13C-NMR, and UV-vis spectroscopic techniques. Crystal structure determination of azulene-1,3-bis(thiosemicarbazone) shows that the thiosemicarbazone units exhibit a syn-closed conformation, with both arms oriented in the same direction and a

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28

Yadav, Meena K., Laxmi Tripathi, and Diptendu Goswami. "SYNTHESIS AND ANTICONVULSANT ACTIVITY (CHEMO SHOCK) OF N-1(SUBSTITUTED-N-4[(4-OXO-3-PHENYL-3, 4-DIHYDRO-QUINAZOLINE-2-YLMETHYL) SEMICARBAZONES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 4 (2017): 359. http://dx.doi.org/10.22159/ajpcr.2017.v10i4.16876.

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Objective: This work is designed at finding new structure leads with potential anticonvulsant activities of 4(3H)-quinazolinone pharmacophore scaffold.Methods: A new series of 4(3H)-quinazolinone pharmacophore was designed with substituted moieties possesses different electronic environment in the hope of developing potent and safe new effective compounds. In such fashion, in this paper, we report the synthesis and anticonvulsant activity (Chemo shock) of N-1(substituted-N-4[(4-oxo-3-phenyl-3, 4-dihydro-quinazoline-2-ylmethyl) semicarbazones 3A-d (1-7), 3B-d (1-7), 3C-d (1-7), their chemical s

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29

Monica, Bedi, Sharma Shilpa, Varshney S., and K. Varshney A. "Synthetic, spectral and antimicrobial studies of bis(cyclopentadienyl)titanium(IV) complexes of semicarbazones and thiosemicarbazones." Journal of Indian Chemical Society Vol. 89, Mar 2012 (2012): 309–13. https://doi.org/10.5281/zenodo.5760244.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India <em>E-mail </em>: anilakv123@rediffmail.com <em>Manuscript received 02 November 2010, revised 05 May 2011, accepted 20 June 2011</em> The reactions of bis(cyclopentadienyl)titanium(Iv) dichloride with semicarbazones/thiosemicarbazones derived by condensing semicarbazide hydrochloride/thiosemicarbazide with suitable ketones viz. 2-hydroxypropiyophenone, 1-acetyl-2-naphthol and 2-acetyl-1-naphthol have been studied in anhydrous tetrahydrofuran and products of the type [(ƞ<sup>5</sup>- C<sub>5</sub>H<sub>5</sub>) T

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30

Paiva, Rojane de Oliveira, Lucimar Ferreira Kneipp, Carla Marins Goular, Mariana Almeida Albuquerque, and Aurea Echevarria. "Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi." Ciência e Agrotecnologia 38, no. 6 (2014): 531–37. http://dx.doi.org/10.1590/s1413-70542014000600001.

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Mycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A. ochraceus, A. parasiticus and Fusarium verticillioides. Thiosemicarbazones had MIC values of 125-500 µg/ml. The thiosemicarbazones 1 and 2 exerted fungistatic activity against Aspergillus spp., and thiosemicarbazone 2 exerted fungicidal activity against F. verticillioides. Compound 2 showed an iron chelating effect of 63%. The ergosterol content of A. par

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B., V. MOHAN KUMAR, SHERIGARA B.S., and A. KHADER A.M. "Trifluoro(oxalato)manganate(III) Oxidations of Thiosemicarbazide, Semicarbazide and their Derivatives." Journal of Indian Chemical Society Vol. 75, Jan 1998 (1998): 11–14. https://doi.org/10.5281/zenodo.5913015.

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Department of Studies in Industrial Chemistry, Kuvempu University, Jnana Sahyadri-577 451 Department of Studies in Chemistry; Mangalore University, Mangalagangotri-574 199 <em>Manuscript received 11 March 1996, revised 30 October /996, accepted 8 February 1997</em> Potassium trifluoro(oxalato)manganate(III) (<em>E</em>'<sub>o</sub>= +1.07 V) is quite stable in the solid state but undergoes decomposition in aqueous solution. The solution stability of the complex in different acid media is studied. The oxidation reactions of potassium triflouro(oxalato manganate(III) with substrates like thi

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32

Möhrle, Hans, та Georg Keller. "α-Dicarbonylmonohydrazone und ihre Acylderivate als Nucleophile und Nachbargruppen/α-Dicarbonylmonohydrazones and their Acylderivatives as Nucleophiles and Neighbouring Groups". Zeitschrift für Naturforschung B 58, № 9 (2003): 885–902. http://dx.doi.org/10.1515/znb-2003-0911.

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The aminomethylation of the α-carbonylhydrazones 1 and 14 with N,N,N′,N′-tetralkylaminals yields only N,N- or C,N-bis-aminomethyl products, but no C-mono-aminomethyl compounds. Phenylglyoxal N-methylhydrazone (24) yields the Mannich bases 27, while anilinocarbonyl hydrazone 29 dependent on the conditions gives rise to the N-aminomethyl derivatives 30 or to the Mannich bases 31. From benzoylhydrazone 33 and semicarbazone 35 the Mannich bases 34 and 36, respectively, are available. Mercury-EDTA reacts with 27 and 31 by twofold dehydrogenation and cyclization to form the lactams 46 and 47, respec

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33

Garg, Sweta, and Ashish Garg. "SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL 2, 3-DISUBSTITUED QUINAZOLIN-4-(3H)-ONES." International Journal of Research -GRANTHAALAYAH 5, no. 6 (2017): 111–22. http://dx.doi.org/10.29121/granthaalayah.v5.i6.2017.2004.

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A new series of 2, 3-disubstituted quinazolin4(3H)one derivatives was synthesized in good yield with the use of different aldehydes and evaluate their antimicrobial and anti-inflammatory activities. Disubstituted quinazolin4(3H)one derivatives were synthesized from Semicarbazide Hydrochloride and semicarbazone as starting materials through oxadiazole as intermediates. This intermediate on reaction with benoxazinone in acidic media, finally converted into corresponding 2, 3-disubstituted quinazolinone derivatives. The synthesized compounds were characterized by their physical properties, Infra-

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34

Sweta, Garg, and Garg Ashish. "SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL 2, 3-DISUBSTITUED QUINAZOLIN-4-(3H)-ONES." International Journal of Research - Granthaalayah 5, no. 6 (2017): 111–22. https://doi.org/10.5281/zenodo.817453.

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A new series of 2, 3-disubstituted quinazolin4(3H)one derivatives was synthesized in good yield with the use of different aldehydes and evaluate their antimicrobial and anti-inflammatory activities. Disubstituted quinazolin4(3H)one derivatives were synthesized from Semicarbazide Hydrochloride and semicarbazone as starting materials through oxadiazole as intermediates. This intermediate on reaction with benoxazinone in acidic media, finally converted into corresponding 2, 3-disubstituted quinazolinone derivatives. The synthesized compounds were characterized by their physical properties, Infra-

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35

Shilpa, Sharma, Bedi Monica, Varshney S., and K. Varshney A. "Some new organotin(IV) complexes of biologically important semicarbazones and thiosemicarbazones." Journal of Indian Chemical Society Vol. 89, Jan 2012 (2012): 41–50. https://doi.org/10.5281/zenodo.5751269.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India <em>E-mail</em> : anilakv123@rediffmail.com <em>Manuscript received 08 September 2010, revised 25 May 2011, accepted 26 May 2011</em> The present paper is a report on the synthesis of some new organotin(IV) complexes by the reactions of bis(tributyltin)oxide and semicarbazones/thiosemicarbazones using benzene as reaction medium. Semicarbazones and thiosemicarbazones are prepared by condensation of 4-acetylbiphenyl, 2-acetylflurene, 9-acetylanthracene, anthraldehyde and 4-flouro-acetophenone with semicarbazide hy

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36

Abaas, Hadeel J., and Mohamad J. Al-Jeboori. "New dimeric complexes with semicarbazone mannich-based ligand; formation, structural investigation and biological activity." Bionatura 8, no. 2 (2023): 1–13. http://dx.doi.org/10.21931/rb/2023.08.02.15.

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The formation of a new semicarbazone Schiff-base ligand (E)-2-(2-(phenyl(2-phenylhydrazinyl)- methyl)cyclohexylidene)hydrazine-1-carboxamide (HL) and its complexes are reported. The new ligand was prepared from the condensation of the Mannich-base 2-(phenyl(2-phenylhydrazinyl)methyl)cyclohexan-1-one (M) with the semicarbazide. A series of metal complexes were prepared by the reaction of the ligand with the metal chlorides of Cr(III), Mn(II), Co(II), Ni(II), Cu(II)), Zn(II) and Cd(II). The structure of the ligand and its complexes were elucidated through analytical and spectroscopic techniques.

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37

Mahmoodi, Nosrat O., Mojtaba Namroudi, Fateme Ghanbari Pirbasti, Hossein Roohi, and Iraj Nikokar. "Practical one-pot synthesis of semicarbazone derivatives via semicarbazide, and evaluation of their antibacterial activity." Research on Chemical Intermediates 42, no. 4 (2015): 3625–36. http://dx.doi.org/10.1007/s11164-015-2235-7.

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38

Maity, Ribhu, Biplab Manna, Swapan Maity, et al. "Synthesis of an Aryl-Semicarbazone-Based Cu(II) Complex for DNA and BSA Interaction and Anti-Cancer Activity against Human Cervix Uteri Carcinoma." Inorganics 12, no. 1 (2024): 19. http://dx.doi.org/10.3390/inorganics12010019.

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The current study provides an in-depth analysis of the biological properties of a Cu(II) complex (C22H24Cu2N6O10) obtained from an aryl-semicarbazone ligand derived (L) from the condensation of 2,4-dihydroxy acetophenone and semicarbazide. The binding behavior of this complex with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) protein was explored using a combination of experimental and theoretical approaches. The results suggest that the complex binds with CT-DNA via a partial intercalation, and hydrophobic interaction. However, the complex binds to BSA protein predominantly through

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39

Peretz, Eliav, and Sanaa Musa. "Design, Synthesis, and Characterization of Novel Cannabidiol-Based Derivatives with Potent Antioxidant Activities." International Journal of Molecular Sciences 25, no. 17 (2024): 9579. http://dx.doi.org/10.3390/ijms25179579.

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In recent years, extensive research has focused on cannabidiol (CBD), a well-studied non-psychoactive component of the plant-derived cannabinoids. CBD has shown significant therapeutic potential for treating various diseases and disorders, including antioxidants and anti-inflammatory effects. Due to the promising therapeutic effect of CBD in a wide variety of diseases, synthetic derivatization of this compound has attracted the attention of drug discovery in both industry and academia. In the current research, we focused on the derivatization of CBD by introducing Schiff base moieties, particu

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40

Asna, Quraishy, and Ahmad Shamim. "Synthesis, characterization and antimicrobial studies of TiIII, MnII, CuII complexes with semicarbazones." Journal of Indian Chemical Society Vol. 82, Jun 2005 (2005): 553–54. https://doi.org/10.5281/zenodo.5830688.

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Department of Chemistry, Bareilly College, Bareilly-243 005, India <em>Manuscript received 15 September 2003, revised 14 December 2004, accepted 3 March 2005</em> Synthesis and characterization of five Schiff bases viz. bis(cinnamaldehyde) semicarbazone (CSCZ), bis(4-chlorobcnzaldebyde) semicarbazone (CBSCZ), bis(3,4,5-trimethoxybenzaldchydc) semicarbazone (TMBSCZ), bis(pyridinc-2-aldchyde) semicarbazone (PASCZ), bis(thiophcne-2-aldehyde) semicarbazone (TASCZ) and their complexes with Ti<sup>III</sup> , Mn<sup>II</sup> , Cu<sup>II</sup> are being described.

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41

Virendra, Singh Shekhawat, Varshney Sarita, and K. Varshney A. "Synthesis of palladium(II) complexes with semicarbazones and thiosemicarbazones using green solvent." Journal of Indian Chemical Society Vol. 94, Jan-2017 (2017): 21–28. https://doi.org/10.5281/zenodo.5603264.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India <em>E-mail</em> : anilakv123@rediffmail.com <em>Manuscript received online 28 August 2016, accepted 01 October 2016</em> A new series of palladium(II) complexes of the type, [Pd(LH)Cl<sub>2</sub> ] have been isolated by the reaction of palladium(II) chloride with semicarbazones and thiosemicarbazones in 1 : 1 molar ratio using green solvent (methyltetrahydrofuran) as a reaction medium. Ligands used in these studies have been prepared by the condensation of semicarbazide/thiosemicarbazide and suitable carbonyls i

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42

Liang, Zhaochang, Yuping Huang, Shiben Wang, and Xianqing Deng. "Synthesis and Biological Evaluation of Some Pyrazole Derivatives, Containing (Thio) Semicarbazide, as Dual Anti-Inflammatory Antimicrobial Agents." Letters in Drug Design & Discovery 16, no. 9 (2019): 1020–30. http://dx.doi.org/10.2174/1570180816666190325163117.

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Background: Several series of pyrazole derivatives containing (thio) semicarbazide (4a-4h, 5a-5l, 6a-6f, 7a-7c) were designed and synthesized to screen dual inflammatory and antimicrobial activities. Methods: The products were characterized by1H NMR, 13C NMR and HRMS. In vitro LPS-induced TNF-α model and in vivo xylene-induced ear-edema model were used to evaluate their antiinflammatory activity. Their in vitro antimicrobial activities were evaluated using a serial dilution method against several gram-positive strains, gram-negative strains and a fungi strain. Results: Bioassays indicated that

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43

Luisi, Grazia, Azzurra Stefanucci, Gokhan Zengin, Marilisa Dimmito, and Adriano Mollica. "Anti-Oxidant and Tyrosinase Inhibitory In Vitro Activity of Amino Acids and Small Peptides: New Hints for the Multifaceted Treatment of Neurologic and Metabolic Disfunctions." Antioxidants 8, no. 1 (2018): 7. http://dx.doi.org/10.3390/antiox8010007.

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Oxidative damage is among the factors associated with the onset of chronic pathologies, such as neurodegenerative and metabolic diseases. Several classes of anti-oxidant compounds have been suggested as having a protective role against cellular stressors, but, in this perspective, peptides’ world represents a poorly explored source. In the present study, the free radical scavenging properties, the metal ion reducing power, and the metal chelating activity of a series of sulfurated amino acids and tripeptides were determined in vitro through canonical assays (DPPH, ABTS, CUPRAC, FRAP, PM, and E

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Petrasheuskaya, Tatsiana V., Ferenc Kovács, Nóra Igaz, et al. "Estradiol-Based Salicylaldehyde (Thio)semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities." Molecules 28, no. 1 (2022): 54. http://dx.doi.org/10.3390/molecules28010054.

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A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1H and ¹³C nuclear magnetic resonance spectroscopy, UV–visible and electron paramagnetic resonance spectroscopy, electrospray ionization mass spectrometry and elemental analysis. The structure of the Cu(II)-estradiol-semicarbazone complex was revealed by X-ray crystallography. Proton dissociation constants of the ligands and stability constants of the metal complexes were determined in 30% (v/v) DMSO/H2O.

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45

Somaiya, Chintan P., Dinesh S. Patel, and Darshan H. Jani. "Synthesis, Spectroscopic, Thermal and in vitro Antimicrobial Activity of Fe(III) and Mn(III) Metal Complexes of Semicarbazone." Asian Journal of Chemistry 32, no. 4 (2020): 789–94. http://dx.doi.org/10.14233/ajchem.2020.22450.

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In this work novel pyrazolone based semicarbazone derivatives and their spectroscopic and biological activities were investigated. Pyrazolone based semicarbazone ligands and their Fe(III) and Mn(III) heterochelates were synthesized. The structure of semicarbazone ligands were confirmed by 1H NMR, IR, elemental analysis and their heterochelates were confirmed by thermal studies (TGA/DTG & DSC) and FAB mass spectroscopy. All the ligands and heterochelates were screened for antimicrobial study against Gram positive (Bacillus megaterium, Bacillus subtilis) and Gram negative (E. coli, Klebsiell

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46

Hania, Majed M. "Synthesis and Antibacterial Activity of Some Transition Metal Complexes of Oxime, Semicarbazone and Phenylhydrazone." E-Journal of Chemistry 6, s1 (2009): S508—S514. http://dx.doi.org/10.1155/2009/204714.

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Co, Ni and Cu complexes have been prepared by reacting metal chloride with 4-chlorobenzaldehyde oxime, 4-methylbenzaldehyde oxime, 4-nitrobenzaldehyde oxime, 4-chlorobenzaldehyde semicarbazone, 4-methyl- benzaldehyde semicarbazone, 4-nitrobenzaldehyde semicarbazone, 4-chloro benzaldehyde phenylhydrazone, 4-methylbenzaldehyde phenyl hydrazone and 4-nitrobenzaldehyde phenylhydrazone and their antibacterial activity have been studied and compared with their ligands againstE. coliwhich gave significant results of activity.

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Fesenko, Anastasia A., Ludmila A. Trafimova, Maxim O. Zimin, Alexander S. Kuvakin, and Anatoly D. Shutalev. "N2-Alkylation of semicarbazones. A general and efficient protocol for the synthesis of 2-alkylsemicarbazides from semicarbazide." Arkivoc 2019, no. 2 (2020): 176–89. http://dx.doi.org/10.24820/ark.5550190.p011.024.

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48

Di Maio, G., S. Li, G. Portalone, K. Zhou, C. Marciante, and R. Spagna. "Cyclohexanone semicarbazone and 4-tert-butylcyclohexanone semicarbazone." Acta Crystallographica Section C Crystal Structure Communications 50, no. 4 (1994): 635–38. http://dx.doi.org/10.1107/s0108270193009369.

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Qazi, Syeda Uroos, Asia Naz, Aqeel Imran, and Jamshed Iqbal. "Urease inhibitory kinetics, molecular docking, SAR and ADME studies of imine analogues." New Journal of Chemistry 46, no. 7 (2022): 3512–20. http://dx.doi.org/10.1039/d1nj05123g.

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50

Reena, T. A., and M. R. Prathapachandra Kurup. "Synthesis, Spectral and Structural Studies of a Novel Semicarbazone Synthesized from Quinoline-2-Carboxaldehyde and N4-Phenyl-3-Semicarbazide." Journal of Chemical Crystallography 40, no. 11 (2010): 927–32. http://dx.doi.org/10.1007/s10870-010-9765-z.

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