Dissertations / Theses on the topic 'Sene'
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Danielsen, Camilla Kolstad. "Potpurri som genrepraksis i Voltaires sene filosofiske fortellinger." Doctoral thesis, Norwegian University of Science and Technology, Department of Scandinavian Studies and Comparative Literature, 2006. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-2136.
Full textKoser, Jaqueline Reginato. "Estrutura populacional e filogeografia de Drosophila antonietae Tidon & Sene." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-01072015-091109/.
Full textDrosophila antoneitae is a cactophilic species, ovipositing primarily in the host cacti Cereus hildmaniannus. Both species are found in drained soils or rocky outcrops in the Missiones region - one of the Seasonally Dry Tropical Forest (SDTF) nucleis, and in south Brazilian coast. The Missiones nuclei comprises the basin of the Paraná-Paraguai Rivers and it is a possible area of climatic stability during the Quaternary oscillations. To evaluate the current distribution of the genetic diversity of D. antoneitae and its association with landscape modifications, the following analyses were performed: populational structure, establishment of phylogeographic hypotheses and demographic events, neutrality tests and paleoecological niche modeling. The mitochondrial gene COI and the nuclear gene period were analyzed. The gene period had low genetic diversity and an homogeneity on the distribution of genetic variability. For gene COI analysis we found a high polymorphism and genetic structure among populations, forming three groups: one in Santa Catarina and Rio Grande do Sul, another in Paraná and São Paulo and the third in the midwestern Brazil. The midwestern population is probably the oldest one, coinciding with the most climatically stable area of this study. This group forms a network of separate haplotypes, due to a high structuring and isolation, probably with Paraná River acting as major barrier for gene flow. We suggest that the possible center of dispersion of the remaining populations of D. antonietae is located in southeastern Brazil, and there were several migration events to other regions of its distribution. There is evidence of shared polymorphism due to recent diversification of populations. Both gene clusters exhibit signs of population expansion, especially in border areas at the Missiones nuclei, where the climate seems less stable. The demographic expansion period is recent and coincides with the major expansion of dry vegetation, which can also play a critical role in structuring populations.
Séne, Ligane Massamba [Verfasser]. "Essays on Modeling and Evaluation of Pro-Poor-Growth Strategies in Africa / Ligane Massamba Sene." Kiel : Universitätsbibliothek Kiel, 2016. http://d-nb.info/1112132279/34.
Full textAraújo, Renata Palhares Zschaber de. "Avaliação comparativa do conteúdo de extrato seco de Sene (Cassia angustifolia Vahl) em cápsulas desenvolvidas com material vegetal e cápsulas convencionais de gelatina." reponame:Repositório Institucional da FIOCRUZ, 2012. https://www.arca.fiocruz.br/handle/icict/13167.
Full textFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos/Farmanguinhos. Rio de Janeiro, RJ, Brasil.
Atualmente, há uma crescente demanda pela disponibilidade de produtos fitoterápicos, para atender tanto o mercado privado quanto a inserção destes produtos no Sistema Único de Saúde. Para a indústria de medicamentos envolvida com a fabricação de fitoterápicos em escala, a estratégia de produção está hoje delineada pela utilização de extratos secos padronizados de espécies medicinais, sob a forma de cápsulas. As cápsulas duras comerciais mais disseminadas são elaboradas a partir de gelatina, que apresentam uma grande limitação de sua eficiência quando o material a ser encapsulado tem características higroscópicas, pois a gelatina é reconhecida por formar ligações cruzadas em condições de alta umidade e temperatura. Este fato tem sido um fator limitante para a indústria farmacêutica, especialmente no que tange à veiculação de extratos vegetais secos, desde que muitos fitoterápicos constituem pós extremamente higroscópicos, o que em última análise compromete a estabilidade do medicamento fitoterápico. O presente estudo teve como objetivo avaliar a eficiência de cápsulas de hipromelose e de gelatina contendo extrato padronizado comercial de Sene (Cassia angustifolia Vahl). As cápsulas de ambos os tipos foram submetidas ao estresse térmico acelerado a 35 graus Celsius (ºC) e 65% de umidade relativa (UR) e a 40ºC/75%U.R. por 6 meses. As medidas comparativas de estabilidade consistiram nas avaliações de (i) perda por dessecação, (ii) desintegração, (iii) suscetibilidade à quebra, (iv) atividade de água, (v) contaminação microbiana, e (vi) análise dos derivados hidroxiantracênicos e dos senosídeos A e B. Os testes físico-químicos foram realizados de acordo com os métodos farmacopeicos em vigor, e a comparação dos conteúdos químicos foi avaliada quantitativamente por Cromatografia Líquida de Alta Eficiência (CLAE), utilizando como marcadores os senosídeos A e B comerciais, cujas presenças nos extratos foram corroboradas com a CLAE acoplada à espectrometria de massas. Os resultados obtidos na caracterização física demonstraram que as cápsulas de hipromelose apresentaram maior estabilidade em todos os parâmetros estudados, quando comparadas as de gelatina. Os resultados da análise química apontaram uma queda maior no teor de senosídeo B para as cápsulas de gelatina em relação às de hipromelose: 0,021% e 0,022%, 30ºC/65%UR e 0,02% e 0,017% 40ºC/75% UR, respectivamente. Estes resultados demonstram preliminarmente que há vantagens no uso da cápsula hipromelose em relação à de gelatina para encapsular o extrato seco de Sene, em um estudo de estabilidade acelerada, no entanto outras avaliações serão necessárias, incluindo um estudo de estabilidade completo no produto.
Currently there is a growing demand for the availability of herbal products to meet both the private market and the inclusion of these products in the Unified Health System. For the pharmaceutical industry involved in the manufacture of herbal medicines in scale, the production strategy is outlined today by the use of standardized dry extracts of medicinal species in the form of capsules. The most widespread commercial hard capsules are made from gelatin, which present a major limitation of its efficiency when the material to be encapsulated has hygroscopic characteristics, because the gelatin is known to form cross-linking under conditions of high humidity and temperature. This has been a limiting factor for the pharmaceutical industry, especially in regard to the placement of dry plant extracts, since many herbal powders are highly hygroscopic, which ultimately compromises the stability of herbal medicine. The present study aimed to evaluate the efficiency of capsules of hypromellose and gelatin containing commercially standardized Senna dry extract (Cassia angustifolia Vahl.). The capsules of both types were subjected to accelerated heat stress at 35 Celsius degrees (°C) / 65% relative humidity (RH) and at 40ºC / 75%RH for 6 months. The comparative measures of stability in the evaluations consisted of (i) loss on drying, (ii) disintegration, (iii) susceptibility to breakage, (iv) water activity, (v) microbial contamination, and (vi) analysis of hydroxyanthracene derivatives and senosídes A and B. The physicochemical tests were performed according to the pharmacopoeial methods in place, and the comparison of chemical content was assessed quantitatively by High Performance Liquid Chromatography (HPLC), using commercial senosídeos A and B as chemical markers, whose presence in the extracts were corroborated by HPLC coupled with mass spectrometry. The results of the physical characterization of the capsules showed that hypromellose capsules showed a higher stability in all these parameters, when compared with gelatin. The chemical analysis results showed a greater decrease in the concentration of senoside B for gelatin compared to hypromellose capsules: 0.021% and 0.022%, 30 ºC/65% R.H. and 0.02% and 0.017% 40 ºC/75% R.H., respectively. These preliminary results show that there are advantages in the use of hypromellose capsule in relation to the gelatin to encapsulate the Senna dry extract in an accelerated stability study, but further evaluation will be needed, including a complete study of stability in the product.
Lavonius, Jakob. "Utopi och fetisch : Modets repressiva och utopiska dimensioner hos den sene Walter Benjamin med utgångspunkt i hans historiefilosofi." Thesis, Södertörns högskola, Filosofi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-32292.
Full textNémeth, Bongers Diane Ella. "Le bon sens dans l’organisation." Thesis, Paris 10, 2017. http://www.theses.fr/2017PA100070/document.
Full textWhile common sense is frequently cited as a core organizational concern, there is no common-sense theory in management science. Thanks to the work of Bourdieu (1980), we have explored common sense as a dyadic concept, comprising two dimensions, common sense and practical sense. Various perspectives depending on the relative importance given to each of its two dimensions show that common sense is multiple. It is a dynamic which articulates together common sense, attached to judgment, and practical sense, attached to reflexivity.To understand the fundamental mechanisms of common sense in organization, we conducted a three-phase, inductive, longitudinal study of a paradigmatic case.The dynamics of common sense in organization results from the combination and interaction between the constitution of judgment and the culture of reflexivity. Our work shows that common sense is based on an alternation between different states, open, closed, opening and closing, thus promoting a "breathing" between the constitution of a judgment and a culture of reflexivity. Common sense can be fully a management tool, provided it is planned and recognized, for an organizational life that is never fully accomplished
Yiu, Kai-bun, and 姚繼斌. "The thought of Seng Zhao (384-414) as seen in Zhao Lun." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1989. http://hub.hku.hk/bib/B31949757.
Full textGuyonvarc'h, Mélanie. "Une sociologie du licenciement au cœur des entreprises "gagnantes" : banalisation de la gestion des licenciements et déstabilisation du rapport au travail des cadres, managers et techniciens." Thesis, Evry-Val d'Essonne, 2008. http://www.theses.fr/2008EVRY0019.
Full textThis research studies the place of redundancy in careers, by confronting the practices of downsizing and the reactions of executives and technicians who have been made redundant. The thesis defends the idea of a “normalisation” of redundancy in the management of employment. The softening of the break due to the redundancy is at the core of this normalisation process led by managers. But such evolutions on the management’s side and the increase of the risk of redundancy do not minimize at all this experience for employees. Redundancy still destabilizes professional identities, even for categories of workers who have been relatively unaffected up to now. When the acceptance of redundancy leads to a new adaptation from employees, this indicates more a necessary reaction than a reconfiguration of a new relationship to the work. Adaptations of employees always remain individual. No clue of collective adaptations has been identified. However the test of redundancy is experienced both individually and collectively, as it destabilizes the working collective in companies
Sendi, Monia. "La géométrie du sens : la polysémie verbale en question." Thesis, Dijon, 2015. http://www.theses.fr/2015DIJOL028.
Full textOur study focuses on the concept of geometry of sense. the study of the concept of verb occupies the main axis of our thesis. This concept is known for its complexity. This is explained by the polysemy of French verbs. We focused our study on the syntactic-semantic analysis of the two verbs "to climb " and "to pass". Indeed, the multiplicity of use involves the notion of verbal polysemy. This notion despite its importance is still very difficult to formulate. We have tried in this study using three electronic dictionaries to disambiguate the verbs "to climb " and "to pass". This work allows us to account for the influence of the syntax and vocabulary of the senses of these two verbs. We explained the opportunity to disambiguate a polysemous verb not by recourse to a list of synonyms but by a set of meanings in specific syntactic constructions. In our approach, we used an automatic method of disambiguation B Victorri that has specificity for the analysis of polysemous lexical units. We found that there is reconciliation between the theoretical analysis and the analysis given by this method. This model is based on linguistic theories and operates mathematics and computer with the aim to clearly describe and solve the problem of verbal polysemy. So our work is multidisciplinary. This is where computer science and mathematics is at the service of the analysis of natural languages
Terrier, Jean-Yves. "Les sens de "sens" et le sens." Lyon 3, 2001. http://www.theses.fr/2001LYO31017.
Full textFischer, Matthias. "Der Intonationstest : seine Anfänge, seine Ziele, seine Methodik /." Frankfurt am Main ; Bern ; Paris : P. Lang, 1996. http://catalogue.bnf.fr/ark:/12148/cb358045610.
Full textYiu, Kai-bun. "The thought of Seng Zhao (384-414) as seen in Zhao Lun Cong "Zhao lun" kan Sengzhao zhi si xiang /." Click to view the E-thesis via HKUTO, 1989. http://sunzi.lib.hku.hk/hkuto/record/B31949757.
Full textBoland, Katherine Ellen. "Sense of Past ... Sense of Place." Thesis, Montana State University, 2008. http://etd.lib.montana.edu/etd/2008/boland/BolandK0508.pdf.
Full textGide, Benoît. "L’existence des corps chez Strawson, Hume et Reid : généalogie d’un traitement naturaliste du scepticisme." Thesis, Paris 1, 2020. http://www.theses.fr/2020PA01H200.
Full textStarting with a distinction between the motives for, the suggestion of external world skepticism, and the demand for a proof or demonstration of the existence of bodies, we first try to analyse the naturalist response to skepticism, as defined and endorsed by Peter Strawson, asking to what category it must belong in order to be maximally efficient. Identifying it to a concessive theoretical diagnosis (part 1), we then question Strawson’s claim that his naturalist treatement of external world skepticism can also be found in Hume as well as in Reid. Underlying Hume’s endeavours to define a mitigated skepticism as the correction of the undistinguished doubts of excessive skepticim by common sense and reflection (part 2), we are led to see how closer is Reid’s criticism of skepticism and defence of common sense realism, in their own context, to Strawson’s epistemic naturalism (part 3)
THEODOROPOULOU, HELENA. "Sens et formation de sens chez eschyle." Poitiers, 1996. http://www.theses.fr/1996POIT5015.
Full textSeye, Boucounta Vieillard-Baron Jean-Louis. "Esprit objectif et esprit absolu chez Hegel." [Poitiers] : [I-médias], 2009. http://theses.edel.univ-poitiers.fr/theses/2009/Seye-Boucounta/2009-Seye-Boucounta-These.pdf.
Full textSeye, Boucounta. "Esprit objectif et esprit absolu chez Hegel." Poitiers, 2009. http://theses.edel.univ-poitiers.fr/theses/2009/Seye-Boucounta/2009-Seye-Boucounta-These.pdf.
Full textOur aim in this present work was to analyze and understand the historical dimension of the objectivized mind in its objective and absolute time in Hegel philosophy without minimizing the contributions of his idealist peers. Therefore, the process of our work has obeyed a ternary structure. The first part is about the historical dimension throughout its great times or detreminist aspect ; family, civil society and the State. It is about the study of human institution from their east to their west, where they are subjected to the universal norms of Reason and Liberty. The expression of Geist which those objective deterministic aspect mediatized, shows however a continuous presence of the contingency whose peculiarity is to put it down in a finished process. So, hit by the negative at its top which is the State in the international relations, the objective mind shows its limits because the mind is not even political ; which arises the necessity of its subordination to the absolute mind, the kingdom of pure thinking, of the mind conscious about itself. That is what we have analyzed in the second part. Here, the absolute mind expresses the Geist in its high sphere, composed of art, religion and philosophy. Finally, the third part deals with the dialectical relation between the objective mind and the absolute mind. The latter has enabled us to understand how the absolute mind is the sphere constituting the basis of the objective evolutionobjective mind- and must be highlighted. What we have learnt from it is the hegelian rehabilitation of religion. In fact, it helps, among others, to make colour-blind people, particulary some hegelian specialists who do not master the religious aspect in the system, to see better and clearly
Mallet, Jeremie. "Le cancer chez l’enfant : du phénomène corporel à sa subjectivation." Thesis, Rennes 2, 2019. http://www.theses.fr/2019REN20013.
Full textA sacred figure of the 21st century, the child, when affected by a cancer pathology, is bound to carry the burden of cultural symbols and of the anxiety - inducing social discourse resulting from them. Sometimes considered a victim, sometimes a hero, an ill child is in fact an object under the influence of the Other ; a control acting through the disease itself, but also by the legitimate anguish of parents, the medical corps and the therapeutic measures that are necessary to reach the desired cure. With particular attention to the singularity of the discourse that we met in the paediatric oncology clinic (children aged 4 to 9 years old), and specifically to the psychological processes involved in the symbolization and in the development of their personal and subjective theories surrounding their condition, we believe that this development of a “signification” – acting as a psychological healing attempt following an incursion into reality – also defines the subject’s involvement in the disease, which frees them from being mere objects Furthermore, when these children show a puzzling symptom or feel the need to find the answer to a question, especially in the afterwardsness of intensive treatments – like a real point altering the constructed signification surrounding the disease – we believe that changing this objectification is possible thanks to analytical work around this signification, which can be deconstructed and reconstructed through the significant’s ambivalence, metaphors and metonymy. An attempt to define a new way of existing marked by the experience with the disease, rather than being prevented by it
Guillet, Sarah. "Généalogie des savoirs contre-insurrectionnels. Irrégularité et sens commun stratégique." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE3065.
Full textThe counter-insurgency knowledge encompasses a variety of documents of different nature: work notes, published pieces, courses given at military schools, official or unofficial doctrines, all of which constitutes a “strategic common sense”. This knowledge however has not been built within military institutions alone: social sciences, chiefly anthropology and ethnology, have provided suitable tools to organise and formalise its content. During the Cold War, this knowledge evolved as it drew closer to sociology and communication & information theories.The chosen genealogical perspective borrows methodological tools from the french philosophical tradition as well as from the critical approaches to international relations. This dissertation demonstrates how counter-insurgency knowledge conveys a specific world representation and that it is not as much obtained from learning and experience as it is a product of intertwined political ideologies justified by scientific demonstrations aiming at promoting a pacified view of the international world order
Chang, Kuo-Hsien. "Sens et altérité : élaboration d'une théorie pratique du sens." Paris 10, 2005. http://www.theses.fr/2005PA100115.
Full textWe elaborate a practical theory of the sense against the authority of the philosophy actualized in the “ Pre-dicat”. This neologism is intended for describe the invariable structure of the philosophical sense in which the contrary terms arrive at a conclusion. Nevertheless, we have no intention to destroy the Pre-dicat. Because the Pre-dicat, considered as our object, has a triple status: as occasional cause, as material, and as symbolic support. Without this status, our theory can't be a practical theory. On the contrary, it is a question of transform the Pre-dicat, of make it work otherwise. In the first chapters, we proceed with studies, which are still philosophical, devoted to Edmund Husserl (German philosopher, 1859-1938), Martin Heidegger (German philosopher, 1889-1976), Emmanuel Lévinas (French philosopher, 1906-1995), à Jacques Derrida (French philosopher, 1930-2004) et à Gilles Deleuze (French philosophe, 1925-1995). But we strive for bring out the fundamental act, which work the Pre-dicat: the philosophical Dire whose character is to resonate between two sides, between the contrary terms. And this character allows us to bring out the different syntaxes of the philosophical Dire. However, we could not transform the Pre-dicat, make it work otherwise, but for the help of a dire whose resonance is no more bilateral. The non- philosophy inaugurated by François Laruelle (French philosopher, 1937- ) propounds a uni-lateral syntax of dire. We restart the Pre-dicat and make it work otherwise by way of this new manner of dire
Boudreault, Lolita. "Sens et non-sens dans le théâtre de Réjean Ducharme." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22566.
Full textThe first chapter examines the textual forces that allow one to trace the narrative structure in Ducharme's dramatic writing. It also describes the different actantial models as well as the mechanisms that regulate their function.
In the second chapter, an analysis of the characters adds a layer of significance to the analysis of the actants and reveals to us the "small world" of Ducharme's plays. The actants take shape, becoming characters who establish ties among themselves.
The third chapter describes the universe in which these "unusual" characters evolve. Space and time throw referential precariousness into relief which in turn, gives a sense of meaning and non-meaning to different objects as well as to the logic of events.
Finally, the fourth chapter deals with the discursive process and, more particularly, with the initiations that stem from the dialogues. With the advent of theatrical communication, the spectator or the narratee is also initiated into Ducharme's theatre where he or she re-assumes his or her place. (Abstract shortened by UMI.)
Lau, Hon-bong Rex, and 劉漢邦. "Colonial garden: a sense of history, a sense of place." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31985233.
Full textRode, Benjamin Paul. "Making sense of common sense : learning, fallibilism, and automated reasoning /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004366.
Full textLau, Hon-bong Rex. "Colonial garden : a sense of history, a sense of place /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25950344.
Full textCarranza, Maxera Maria. "Making sense of common sense : female sterilisation in Costa Rica." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619857.
Full textFréchin, Véronique. "Teo Hernandez : l'éveil des sens et la quête du sens." Paris 3, 2003. http://www.theses.fr/2003PA030144.
Full textLussac, Olivier. "Land art. Sens et non-sens de la sculpture contemporaine." Paris 3, 1995. http://www.theses.fr/1996PA030036.
Full textLand art is an artistic movement, concerning different forms of sculpture in nature and landscape, during the 60s and 70s. This study propose historical and aesthetical analysis. Particularly we should try to understand what are the dialectic of sight and nonsight, the sublime and the picturesque in the gardens and land art, the photographic and cinematographic dimensions of sculpture. Having pionnered of earth art and land proving themselves in the pratice of both art and theory, r. Smithson, r. Morris, m. Heizer, w. De maria (and r. Long in england) developped a multiofaceded oeuvre that has nourished and challenged artistic traditions fixed in the field of the sculpture. The investigations of these artists took on a wide of range of forms from the very beginnings: object, photography, text, performance, installation, map. . . Land art attempts to go beyond the narrow sphere of sculpture, philosophical and historical questions of the day
Rolland, Jean-Luc. "Genèse et filiations du fondamentalisme protestant (1910-1925)." Thesis, Montpellier 3, 2015. http://www.theses.fr/2015MON30003.
Full textFrom the late 1860s to the mid-1920s, American Protestantism saw the rise of an anti-Modern theological trend. At the end of this period, its adherents chose to call themselves Fundamentalists. This reaction was not totally unprecedented : it was a resurgence of the most conservative tendencies, not only from the United States, but also from Europe. Our research into this ideological environment attempts to trace the origins of this trend and reflect on the nature and status of its doctrinal statements. This early Fundamentalism has been the subject of many studies ; mostly in the English language, the majority of which focus on the content of its doctrines. We propose to go beyond this normative-descriptive dimension and concentrate our research on the history of the movement, the context of its genesis and related issues. Fundamentalism does not merely revolve around orthodoxy. Our analysis therefore aims to scrutinise its relationship to its own beliefs as well as the way it views those who oppose its tradition. The first part of our study relates to the initial phase of Fundamentalism from the 1910s to the 1920s, taking into account the main controversies and publications of this period. The second part looks at the roots - religious and philosophical in particular - which have favoured its emergence. The third part analyses Protestant Modernism ; an extremely diverse movement which was to be the target of fundamentalist attacks. To conclude we shall carry out a comparative study of Protestant Fundamentalism and a Catholic anti-Modernist movement of the same period. Based on original documents studied, we propose a definition of the fundamentalist phenomenon, drawing from the history of these two Christian dogmatisms of the early twentieth-century
Kastowski, Martin [Verfasser], Matthias [Akademischer Betreuer] Hinderer, and Stephan [Akademischer Betreuer] Kempe. "Abschätzung der Kohlenstoffspeicherung und –freisetzung in Seen Europas: Ein Beitrag zur Eingrenzung der fehlenden Senke im globalen Kohlenstoffkreislauf / Martin Kastowski. Betreuer: Matthias Hinderer ; Stephan Kempe." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2011. http://d-nb.info/1105563065/34.
Full textAmzal, Rachida. "Pharmacothérapie ciblée dans la cholestase intrahépatique familiale progressive de type 2 (PFIC2)." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS187.
Full textABCB11/BSEP is the main bile acids transporter located at the canalicular pole of hepatocytes. Mutations of ABCB11 are responsible for progressive familial intrahepatic cholestasis type 2.During my phD, I evaluated the ability of aminoglycosides and PTC124 to induce readthrough of premature termination codons, targeting and function of nonsense and missense mutants of Bsep and also the effect of combined therapy (readthrough + chaperone).In our expermental models, gentamicin increased readthrough of p.R1090X mutation NIH3T3, HEK293 and Can 10 lines. The resulting full-length protein was detected at the plasma membrane of HEK293 and at the canalicular membrane of Can 10 cells; and was partially functional since it was responsible for increasing the transport activity of 3H-taurocholate (3H-TC) in MDCK clones. These effects were potentiated by the addition of chaperone drugs such as 4-phenylbutyrate (4-PB).I have also demonstrated the ability of new 4-PB derived compounds (MHMPB, OTNC and HMPB) to correct mistrafficking and to increase 3H-TC transport of BsepR1128C missense mutant at lower concentrations than 4-PB. Finally, I showed that other chaperone drugs (GPB, PA, SAHA, and C18) were able to correct mistrafiking of BsepR1128C and to increase its 3H-TC transport activity in MDCK clones
Pin, Didier. "Approche communicationnelle de l'organisation humaine des systèmes d'information." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4347.
Full textThis thesis presents the role of communication in human organization of the University's Information System. By human organization, we mean all the different socio-technical groups constituting the technical servicing of an establishment. The approach is communicative, here the link to understand the interactions of individual and collective actors within departments. Our status as DSI Director of the University Paul Cézanne has allowed us to conduct a comprehensive research field. This was particularly highlighted the relational logics that give greater efficiency to the information system. The initial question is how to optimize the IF of a University. To answer this question, we looked for in Information Science and Communication, the theoretical foundations linking. The work of the School of Palo Alto and especially its implementation in the orchestral model gave us the conceptual tools to build a better understanding of the dynamics of relationships. Communication thus became the key practices and common usage that build an IS. It becomes a catalyst for understanding between business and even, in some respects, the link between the technical and human factors. With our approach, both conceptual (the PhD's) and practice (the profesionnal's), we identified the different visions of SI perceived by the actors and we have put forward their ambivalence and their complementarities. Therefore, the computational aspects are generally put forward a simple vision repositioned as special issue of one of the groups, the engineers' one
Dale, Jolene Marie. "Sense of memory." Thesis, Montana State University, 2010. http://etd.lib.montana.edu/etd/2010/dale/DaleJ0510.pdf.
Full textTan, Yoo Guan. "Sense and meaning." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316794.
Full textFreeman-Core, Charles W. "Sense and definitions." Thesis, University of Warwick, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283483.
Full textLancaster, Neil Patrick James. "Common sense leadership." Thesis, Sheffield Hallam University, 2011. http://shura.shu.ac.uk/19939/.
Full textNGUYEN, THANH BINH. "Sens, situation, intentionalite." Paris 4, 1988. http://www.theses.fr/1988PA040049.
Full text'how can meaning be the source of contextual constraints', and 'how does the speaker purport to get the hearer to fulfill the conditions of satisfaction of his speech act'are the two questions 1 address myself to. The first question is susceptible of two types of answer: in intentional terms, when construed as a question about the logical structure of meaning; in terms of the double notion of endorsement commitment, when taken to bear on the relation between s and h. Chapter one, which deals with this question, also takes up such related issues as'background and representation', communicative intention' and' semantic versus intentional consistency'. The second question 1 answer in chapter two in terms of contextual transformations: in the absence of guaranteed means s could avail herself of to get h to do what is expected from him, all s can do is provide h with the means to understand and evaluate the content of her intention; or rather, to construct the relevant contexts of comprehsion and evaluation. Accordingly, s's utterance will trigger a series of transformations of h's mental context, which transformationsform the necessary prerequisite for those further contextual transformations. Chapter three is concerned with the extent to which those various modifications of the context are anchored in meaning. Its main focus is on those expressions which can be said to carry the relevant instructions intended for the comprehension process
Thune, Lucie Noel. "Sense of Duration." VCU Scholars Compass, 1998. http://scholarscompass.vcu.edu/etd/1279.
Full textClay, Bernard. "The (Un)seen." UKnowledge, 2017. http://uknowledge.uky.edu/english_etds/55.
Full textSéré, Yves Yacouba. "Effet de la biosynthèse de lipides sur la toxicité de l'α-synucléine, protéine impliquée dans la maladie de Parkinson, chez Saccharomyces cerevisiae." Poitiers, 2010. http://theses.edel.univ-poitiers.fr/theses/2010/Sere-Yves-Yacouba/2010-Sere-Yves-Yacouba-These.pdf.
Full textParkinson’s disease is a neurodegenerative pathology that has been linked to several genetic mutations of the SNCA gene encoding the pro-oxidant α-synuclein protein. The budding yeast S. Cerevisiae is a valuable model to study cellular and molecular mechanisms of α-synuclein toxicity. Indeed heterologous expression of α-synuclein is toxic to wild type yeast, and recapitulates the main features of damages caused to mammalian neurons including an increase of neutral lipids storage (triglycerides and steryl esters, embedded into lipid droplets). To address the significance of this accumulation, we forced α-synuclein production in a strain unable to synthesize triglycerides and steryl esters. Surprisingly, inability to store neutral lipids rendered cells more tolerant to α-synuclein. Our results indicate that the level of !-synuclein toxicity is correlated to fatty acid synthase activity and intracellular redox state
Fornstedt, Joachim. "Sena ändringar : studie av sena ändringar under produktionsfasen av Kv. Valhall." Thesis, Högskolan i Gävle, Avdelningen för bygg- energi- och miljöteknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-11992.
Full textCollins, Allyson T. (Allyson Therese). "Sense and sense-ability : the artful science of hands-on medicine." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45340.
Full textIncludes bibliographical references (leaves 39-42).
Listening to lung sounds, feeling the pulse, observing posture and gait-these are just a few of the examinations that doctors perform on their patients. A physical exam exists for every organ, from the brain to the bones of the feet, each carried out with the physician's senses. For thousands of years, humans had been solely responsible for this exam ritual, until the emergence of diagnostic equipment-CT scans, MRI scans, ultrasounds, echocardiograms, mammograms, and more. In some cases, these devices replaced the physical exam. But in areas of the world where technology is unavailable, and even in places where it exists, many physicians and healthcare professionals cannot or will not to cede their tasks to tools. Their goal: to maintain an environment in which technology and the learned senses can coexist; an environment in which the physical exam remains an integral part of medicine.
by Allyson T. Collins.
S.M.in Science Writing
Giudicelli, Michelle. "Jorge de Sena, l'insurgé : pour une lecture de Jorge de Sena." Paris 3, 1994. http://www.theses.fr/1995PA030048.
Full textThis thesis falls into two volumes, representing a text of eight hundred and eighty pages. The first volume opens on a synthetic study of two hundred and thirty pages which pretends to bring into relief, under the light of this subversion the writer was so fond of, the fundamental unity of the whole of jorge de sena's works. The second volume includes more punctual studies, already published or to be published, that is to say about two hundred and fifty pages that, as they emphasize more precisely this or that aspect of the author's life or works, deal with various aspects of sena's world, even deepening into its very complexity. As an appendix to the first volume appears a selection of hitherto unpublished letters sent by jorge de sena to adolfo casais monteiro; some letters sent to us by mecia de sena, as well as various accounts (pedro tamen, nuno judice, joaquim manuel magalhaes and miguel fernandes jorge) on jorge de sena's personality and on the importance of this works in contemporary portuguese literature. The analytic studies of the second volume are complemented with an appendix which consists in early texts, unpublished at the moment we studied them, and also in a thrity-four pages bibliography and a ten page general index. According to the significative intertextuality which rules jorge de sena's works, our synthetic analysis was based on the extented corpus constituted by all his writings
Liégeois, Patrick. "Heidegger et le sens du sens : acheminement vers la pensée tautologique." Paris 4, 1988. http://www.theses.fr/1987PA040062.
Full textIn metaphysics, one always deals with being; but, according to Heidegger, the sense of being is hardly ever actually dealt with. That gap seems to hold an aporia: that of the "sense of sense". In my opinion, the incompleteness of the inaugural phenomenology (1927) could lie in the impossibility of reaching the sense of sense as the centre of the hermeneutic circle. After the "kehre", in the thought of the "truth of being", the sense can be understood as an eschatological progress (weg), set free from the method and the metaphor. Within a third period, that of the "locality of being" sense can be understood, from the ereignis, as the centre of the quadriparty (geviert) : only then would the sense of sense as centre of the hermeneutic circularity be reached. Such a circularity belongs to a last phase in Heidegger’s thinking : the phenomenology of the inapparent as a tautological thought (1973). One would deal with a thought of the ereignis as tautological or sigillary significance
Vignemont, Frédérique de. "Who's who ? : soi, sens de l'agentivité et sens de la propriété." Paris, EHESS, 2002. http://www.theses.fr/2002EHES0064.
Full textUsing empirical results from neuroscience, neuropsychology and psychopathology, I test the philosophical theory about self-knowledge sustained by Shoemaker that assert that self-attribution of mental and bodily states can never be false. Suppose that I'm an amnesiac. I could mistakenly assert that I am Plato. But when I say that I am thinking, even if I have no information about myself, it seems that it makes no sense to ask whether I am the person who is thinking (Wittgenstein, 1958; Shoemaker, 1996). As I alone have an introspective access to my mental states, we can wonder why I should need to make explicit the fact that they are my own states outside a communicative context. However, this privileged access does not guarantee that I recognize these states as mine. Indeed, xenopathic experiences in schizophrenia and the alien hand syndrome show that whether one is the owner of one's own mental and bodily states is not always obvious. This is not so surprising given the proximity between oneself and the others. The phenomena of empathy and imitation show that we use representations that are partly neutral as to who the subject is. Consequently, I suggest that far from being superfluous, the first-person concept is the product of an underlying cognitive process of self-attribution that needs to be investigated. I start from the sense of agency and I point out the importance of the control of one's own actions for determining whether I am the agent. Then, I show that this notion of control also plays a role in recognizing one's own body. Finally, I ask myself whether we should understand self-attribution of thoughts on the model of agency
Miller, Tristan. "Adjusting Sense Representations for Word Sense Disambiguation and Automatic Pun Interpretation." Phd thesis, tuprints, 2016. https://tuprints.ulb.tu-darmstadt.de/5400/7/Miller_thesis_20160411_print.pdf.
Full textLandès, Sophie. "Organisation conceptuelle de l'activité d'adaptation du psychomotricien : une approche par le sensible de l'analyse de l'activité dans une perspective de didactique professionnelle." Thesis, Cergy-Pontoise, 2018. http://www.theses.fr/2018CERG0939/document.
Full textPsychomotor therapists belong to the category of the professions of the relation. The perspective of this profession and its conceptual field in which it is anchored differ from those related with an activity of production; This professional activity is entirely characterized by its interactional nature. The approaches of psychomotor therapists are at the intersection of therapy, rehabilitation and/or education. Originally addressed to children with a compromised development, those practices are now relevant to people of all ages, from the healthy to sick subjects as well as to subjects having circumstantial difficulties. The scope of the field of competence and the extension of the fields of intervention leads us to question the specificity of the activity of the psychomotor therapist while he intervenes with his patients or his partners of working session. Our research focuses on the analysis of this professional activity. The matter is not to study the work or to describe the job. The way of he realizes his activity in situation of intervention and the way he organize its spatial and temporal development are what we attempt to understand. In the processes of conceptualization that underlie the conduct of one's activity in a situation, there are forms of invariant organization of one's activity, concepts that organize it.Our research takes place in the theoretical framework of adult learning, i.e. professional didactics. Our analysis is based on an interactional and multimodal approach of the professional activity, an approach through the sensible. In this activity appears a specific structure of development that we call "choregraphical strategy". It comes in an organizational dynamic underlied by the implementation of a specific pattern, that we call “sens of balance pattern”. Composition, moderation and flexibility characterize it. Our research contains issues related to professional training. It also includes opportunities for professional development
Unwin, Matthew M. "Molecular Systematics of the Eriocaulaceae Martinov." View electronic version of this work, 2004. http://www.ohiolink.edu/etd/send-pdf.cgi?miami1082582823.
Full textHsieh, Ching-Hsuan Lily Bantock Granville Warlock Peter Bliss Arthur Lambert Constant. "Chinese poetry of Li Po set by four twentieth century British composers Bantock, Warlock, Bliss, and Lambert /." Columbus, Ohio : Ohio State University, 2004. http://www.ohiolink.edu/etd/send-pdf.cgi?osu1086095656.
Full textTitle from first page of PDF file. Document formatted into pages; contains xiii, 146 p. : ill. Advisor: Loretta Robinson, School of Music. Includes bibliographical references (p. 132-136).
Yen, Hsin-Yi. "NEW ANALYSIS AND DESIGN PROCEDURES FOR ENSURING GAS TURBINE BLADES AND ADHESIVE BONDED JOINTS STRUCTURAL INTEGRITY AND DURABILITY." [Columbus, Ohio] : Ohio State University, 2000. http://www.ohiolink.edu/etd/send-pdf.cgi?osu967666610.
Full textIncludes vita. Title from title page display. Abstract. Advisor: M.-H. Herman Shen, Dept. of Aerospace Engineering, Applied Mechanics, and Aviation. Includes bibliographical references (p. 152-154).
Wang, Xinglong. "Automatic acquisition of sense examples for word sense disambiguation : a bilingual approach." Thesis, University of Sussex, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439620.
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