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Journal articles on the topic 'Senna Extract'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Monteiro, J. A., J. M. Ferreira Júnior, I. R. Oliveira, et al. "Bioactivity and Toxicity of Senna cana and Senna pendula Extracts." Biochemistry Research International 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/8074306.

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This work investigated the content of total polyphenolic compounds and flavonoids as well as their toxicity and larvicidal and acetylcholinesterase inhibitory activities. The antioxidant activities of two medicinal Senna species extracts (Senna cana and Senna pendula) were also investigated. The ethanol extract of the leaves of S. cana and the ethanol extract of the branches of S. pendula presented the best performance in the DPPH/FRAP and ABTS/ORAC assays, respectively. For the inhibition of acetylcholinesterase, the hexane extract of the flowers of S. pendula presented the lowest IC50 value

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2

Husseini, H. A., Olonitola, O.S., and Aliyu, M. S. "Phytoconstituents and antidermatophytic activity of crude extracts of Senna occidentalis." UMYU Journal of Microbiology Research (UJMR) 8, no. 1 (2023): 152–60. http://dx.doi.org/10.47430/ujmr.2381.019.

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Dermatophytes are one of the major aetiologic agents of cutaneous mycoses Senna occidentalis is among the plants used in traditional herbal medicine in treating fungal skin infections and it is shown from literature to contain phytochemicals which are attributed to its antidermatophytic activity. This work is aimed at determining the Phytoconstituents and antidermatophytic activity of leaves and seeds crude extracts of the Senna occidentalis plant . The study is a qualitative study that determines the phytoconstituents and antidermatophytic activity of the plant extracts on some clinical derma

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3

D.Kanakamahalakshmi, D. Kanakamahalakshmi, D. DilleswaraRao D.DilleswaraRao, G. Sai Ramesh G.Sai Ramesh, and P. Phaneendra P.Phaneendra. "Antimicrobial Activity of Some Plant Extractions." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 1543–49. https://doi.org/10.35629/4494-100315431549.

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This study evaluates the antimicrobial properties of extracts from Senna morning and Tinospora species against common pathogenic microorganisms. The extracts were prepared using solvents like ethanol, methanol, and water, and antimicrobial testing was performed using disk diffusion and broth micro dilution methods. Results showed varying degrees of antimicrobial activity, with both plant extracts showing significant inhibition against Grampositive and Gram-negative bacteria and fungal strains. The findings support the potential of Senna morning and Tinospora as natural antimicrobial agents, pr

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4

*K., Purushotham P. Nandeeshwar V. KiranKumar I.Srikanth Dr. K. Ramanjaneyulu J. Himabindhu. "EVALUATION OF IN VITRO ANTI UROLITHIATIC ACTIVITY OF SENNA OCCIDENTALIS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1994–97. https://doi.org/10.5281/zenodo.1213630.

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The present study was explores that evaluation of in vitro antiurolithiatic activity of Senna occidentalis. It was observed that thehighest calcium oxalate crystals dissolution was observed in the ethanolic extract of Senna occidentalis. It was found that ethanolic extract of Senna occidentalis has more efficient to dissolve calciumoxalate. In this study Neeri was used as standard drug. Key words: Senna Occidentalis, urolithiasis and Ethanolic extract

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5

Kowalczyk, Tomasz, Przemysław Sitarek, Tomasz Śliwiński, et al. "New Data on Anti-Inflammatory and Wound Healing Potential of Transgenic Senna obtusifolia Hairy Roots: In Vitro Studies." International Journal of Molecular Sciences 24, no. 6 (2023): 5906. http://dx.doi.org/10.3390/ijms24065906.

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Asthma is an inflammatory disease whose etiology remains unclear. Its characteristics encompass a wide range of clinical symptoms, inflammatory processes, and reactions to standard therapies. Plants produce a range of constitutive products and secondary metabolites that may have therapeutic abilities. The aim of this study was to determine the effects of Senna obtusifolia transgenic hairy root extracts on virus-induced airway remodeling conditions. Three cell lines were incubated with extracts from transformed (SOA4) and transgenic (SOPSS2, with overexpression of the gene encoding squalene syn

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6

Assonfack, Derick J., Eric Cadet, Larissa Mpude, et al. "Botanicals from the flowers of Vernonia calvoana and the leaves of Senna spectabilis showed anti-Klebsiella activity and potentiated the activity of antibiotics against multidrug-resistant phenotypes overexpressing efflux pumps." Investigational Medicinal Chemistry and Pharmacology 7, no. 3 (2024): 1–9. https://doi.org/10.31183/imcp.2024.00101.

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Background: The alarming trend of infectious diseases in public health is mainly due to bacterial multidrug resistance, the emergence of which is partly caused by the inappropriate use of antibiotics. Bacteria of the Klebsiella genus have acquired a priority level of resistance to antibiotics, reducing their effectiveness. The aim of this study was to evaluate the anti-Klebsiella activity of methanol extracts of Vernonia calvoana flowers and Senna spectabilis leaves against multidrug-resistant Klebsiella phenotypes overexpressing efflux pumps. Methods: The antibacterial activity of Vernonia ca

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7

James, Olowoyeye Odunayo, Oluwadare Olusegun Emmanuel, Gabriel Ayodeji Saanumi, Owolabi Oluwafemi Akinkunmi, and Abideen A. Adekanmi. "Senna Alata Leaf and Stem: Phytochemical Screening, Nutritional Content, and Antimicrobial Activities." Journal of Environmental Impact and Management Policy, no. 26 (October 19, 2022): 1–11. http://dx.doi.org/10.55529/jeimp.26.1.11.

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In the current examination, the nutritional composition, phytochemical content and antibacterial activities of an extract from Senna alata leaf and stem were all evaluated. The Candle bush (Senna alata) leaf and stem were then cleaned, allowed to air dry at room temperature, and then ground. In ethanol aqueous solutions, extracts of the leaves and stems were produced. To ascertain the nutritional composition, antibacterial content, and phytochemical property, standard techniques were employed. Moisture content, crude protein, crude fat, ash content, crude fat and carbohydrate for Senna alata w

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8

YAKUB, ABBA UMAR, ANKITA MATHUR, and SANI YAHAYA. "In vitro Antiplasmodial Actitvity of Aqueous and Ethanol Stem And Leaf Extracts of Senna Occidentalis (Coffee Senna)." Current Research in Pharmaceutical Sciences 12, no. 2 (2022): 83–90. http://dx.doi.org/10.24092/crps.2022.120202.

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Development of resistance against the frontline anti-malarial drugs has created an alarming situation, which requires intensive drug recovery to develop new, more effective, affordable and accessible anti-malarial agents. Plants as Senna occidentalis produce a wide variety of phytochemical constituents, which are secondary metabolites and are used either directly or indirectly in the pharmaceutical industry. Phytochemical screening and antiplasmodial activity of the aqueous and ethanol extracts of S. occidentalis (L.) leaves and stems were studied in this work. The preliminary screening of the

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9

Saminu, Sufiyanu, and Sadiya Na’ala. "Evaluation of Phytochemical Constituents and Antibacterial Activity of Methanolic and Aqueous Leaf Extracts of Coffee Senna (Cassia occidentalis L.)." Caliphate Journal of Science and Technology 4, no. 2 (2022): 160–64. http://dx.doi.org/10.4314/cajost.v4i2.5.

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Cassia occidentalis commonly known as Coffee senna is a herbaceous plant that belongs to the family fabaceae. The plant is called “Sanga-Sanga" in Hausa, “Ewe Oriesi” in Yoruba, and “Akidi Agbara” in Igbo. Coffee senna is a pan-tropical plant. This research was aimed at evaluating the phytochemicals and antibacterial activity of extracts of leaves of Coffee Senna. Plant leaf samples were collected behind Department of Biological Sciences Federal University Gusau. The samples were air dried and grounded into powder using mortar and pestle. The phytochemical analysis of both methalonic and aqueo

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10

Prabha Lahare, Rajeshwari, Yogesh Kumar Bisen, Hari Shankar Yadav, and Anil Kumar Dashahre. "TLC BASED PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT ACTIVITY OF SENNA ALATA." International Journal of Advanced Research 8, no. 11 (2020): 1099–107. http://dx.doi.org/10.21474/ijar01/12106.

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Senna alata is an ornamental flowering plant also known as ringworm bush and candle bush belongs to Leguminaceae family and used mainly as antifungal agent .The plant is pharmacological significant and used as antibacterial, antioxidant, anti-cancerous, anti-mutagenic, antifungal, anti-diabetic and antiviral activities. Leaves of the plant have anti-parasitic activity used in treatment of eczema, ringworm, asthma, bronchitis and in poisonous insect bites, bark of the plant is used in treatment of skin diseases. In the present study chloroform, methanol, petroleum ether and aqueous extracts wer

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11

Peterson, Joseph K., and Howard F. Harrison. "Differential Inhibition of Seed Germination by Sweetpotato (Ipomoea batatas) Root Periderm Extracts." Weed Science 39, no. 1 (1991): 119–23. http://dx.doi.org/10.1017/s0043174500057970.

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The effect of sequential hexane, ethyl acetate, and aqueous methanol extracts of ‘Regal’ sweetpotato periderm on seed germination of sweetpotato, proso millet, and seven weed species was studied. The hexane extract, which contained the nonpolar components of the periderm tissue, was least inhibitory. It inhibited velvetleaf, proso millet, black nightshade, and redroot pigweed germination, and maximum inhibition was 56% for black nightshade at 200 mg of periderm extracted ml–1. The ethyl acetate fraction was inhibitory to proso millet, velvetleaf, black nightshade, goosegrass, tall morningglory

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12

Rahmawati, Fri, Nur Nunu Prihantini, and Bella Christina Hady. "In Vitro Bioactivity Test of Senna Alata (L.) Roxb Leaves Extract." International Journal of Health Sciences and Research 12, no. 2 (2022): 304–17. http://dx.doi.org/10.52403/ijhsr.20220241.

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Traditionally, Senna Alata (L.) Roxb (Ketepeng Cina) has been used as an alternative medicine for typhus, diabetes, malaria, herpes, eczema, asthma, stomach ulcers, syphilis, influenza, bronchitis, intestinal worms, fungal skin diseases such as tinea versicolor, ringworm and scabies. The study's objective was to determine the active compounds, antioxidant potency and antifungal activity of Senna Alata (L.) Roxb leaves extract. Samples were extracted using the maceration method with 70% ethanol, ethyl acetate and N-hexane as solvents. Phytochemical analysis used the Harbone method, antioxidant

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13

Adeosun, Ebenezer Kolawole, Patience Ogbenyeanu Nwadiaro, and Festus Chukwuemeka Onwuliri. "Phytochemical Screening, Antibacterial and Antioxidant Activity of Senna Alata Leaf Extract." International Journal of Advanced Academic Research 10, no. 10 (2024): 108–22. https://doi.org/10.5281/zenodo.13992453.

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<em>Medicinal plants are gaining acceptance globally, Senna alata being one of the many that herbal practitioners are using to cure a wide range of diseases. This study is aimed to determine the antibacterial effect of Senna alata on multidrug resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus and to determine its antioxidant activity. </em><em>Cold, Hot aqueous and 80% Methanolic extracts of Senna alata were used for the analysis. Kirby-Bauer disc diffusion method, Agar Well Diffusion (AWD), Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC

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14

Jani, Deepti Kaushalkumar, and Sunita Goswami. "Effect of Senna and Radish Extracts on Hepatic Function in High Fat Diet Fed and Diabetic Rats." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 1164–67. http://dx.doi.org/10.22270/jddt.v9i3-s.3661.

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Hyperlipidaemia and diabetes are widely associated with liver injury. Senna and radish leaves have been reported to possess anti-diabetic, anti-oxidant, and anti-hyperlipidemic activities. However, there is not enough information of these herbal medicines on hepatic function of rats with metabolic disorders. Therefore, the objective of the current study was to screen herbal extracts of senna and radish leaves on hepatic function in high fat fed and diabetic rats. Qualitative phytochemical investigation was done as per standard procedures. Quantitative phytochemical investigation was done using

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15

R, Abarna, and Jinisha Blessie J.P. "Sustainable Management of Tomato Early Blight with Plant Extracts." International Journal of Environment, Agriculture and Biotechnology 9, no. 4 (2024): 077–82. http://dx.doi.org/10.22161/ijeab.94.11.

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This study focused on developing eco-friendly management strategies for early blight disease in tomatoes, caused by Alternaria solani, through the use of botanical extracts from eight plants: Neem, Prosopis, Nerium, Senna, Lantana, Pungam, Coconut, and Calotropis. The research was carried out at the Agricultural College and Research Institute in Vazavachanur, Thiruvannamalai, to assess these botanicals in vitro and in vivo effectiveness against the pathogen. In laboratory conditions, the extracts were tested at a 10% concentration, and their ability to inhibit the pathogen's mycelial growth wa

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16

ANIBIJUWON, Ibikunle Ibitayo, Ifeoluwa Deborah GBALA, Bright Ifeanyi NNADOZIE, and Olubukola IFAYEFUMI. "Susceptibility of Selected Multi-Drug Resistant Clinical Isolates to Different Leaf Extracts of Senna alata." Notulae Scientia Biologicae 10, no. 1 (2018): 26–32. http://dx.doi.org/10.15835/nsb10110176.

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The present study evaluated the antibacterial effects of the methanolic, ethanolic and aqueous extracts of Senna alata leaves. The extracts were tested using agar well diffusion method against selected clinical isolates: Salmonella typhi, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumoniae. Antibiogram profile of the isolates deduced by disc diffusion method confirmed that the methanolic extract inhibited the growth of all tested organisms except for Klebsiella pneumoniae, which also showed no sensitivity to the ethanolic extract. There was no inhibition o

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17

Alkali, Kaumi, M. M. Hamza, M. M. Shehu, M. B. Abdulhamid, and H. Audu. "Qualitative and Quantitative Phytochemical Screening of Aqueous, Methanol, and Hexane Leaf Extracts of Senna siamea." Sahel Journal of Life Sciences FUDMA 3, no. 1 (2025): 328–36. https://doi.org/10.33003/sajols-2025-0301-40.

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Senna siamea is a remarkable plant traditionally recognized for its potent antimicrobial, antifungal, and antimalarial properties. This study was conducted to identify the phytochemical compounds responsible for these therapeutic effects. Fresh leaves were collected and subjected to extraction using water (aqueous), methanol, and hexane solvents. These extracts were then analyzed for phytochemical constituents employing standard methodologies. The phytochemical screening of all crude extracts indicated the presence of saponins, tannins, steroids, phenols, alkaloids, and flavonoids. In the aque

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18

Issa, Tahani Osman, Ahmed Ibrahim Mohamed Ahmed, Yahya Sulieman Mohamed, Sakina Yagi, Abdelrafie Mohamed Makhawi, and Tarig Osman Khider. "Physiochemical, Insecticidal, and Antidiabetic Activities of Senna occidentalis Linn Root." Biochemistry Research International 2020 (September 15, 2020): 1–9. http://dx.doi.org/10.1155/2020/8810744.

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The present study aimed to investigate the physiochemical activities of Senna occidentalis (Linn) roots and phytochemicals as insecticidal (ethyl acetate and methanol) and antidiabetic (ethanolic extract) activities. Physicochemical properties were carried out by using Association of Official Analytical Chemist methods; thin layer chromatography was carried out according to the Stahl method. Larvicidal activity and LD50 were studied against the third instar of Culex quinquefasciatus mosquito larvae to detect and extract toxicity. The ethanolic extracts of the roots were orally tested at the do

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Morales, M. A., D. Hernández, S. Bustamante, I. Bachiller, and A. Rojas. "Is Senna Laxative Use Associated to Cathartic Colon, Genotoxicity, or Carcinogenicity?" Journal of Toxicology 2009 (2009): 1–8. http://dx.doi.org/10.1155/2009/287247.

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Due to their natural origin, apparent low oral toxicity, effectiveness, and accessibility without a medical prescription, the anthranoid laxatives are a popular remedy for constipation and are frequently used abusively. Therefore, it is important to characterize its harmful and/or toxic effects. The sennosides, main active metabolites of senna, exhibit a very low toxicity in rats, and its genotoxic activity in bacterial strains as well as mammal cells was classified as weak in those cases where it was shown to be significant. The toxicological and mutagenic status of the crude extract of senna

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20

Banso, Aderotimi, S. Dachi, J. I. Usman, A. E. Ajewole, and N. Etsu-Musa. "Exploring the antioxidant performance and identification of bioactive phytochemicals of leaf extracts of Senna alata (L.) Roxb." Journal of Current Opinion in Crop Science 5, no. 2 (2024): 70–77. http://dx.doi.org/10.62773/jcocs.v5i2.237.

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Senna is a highly-producing Leguminosae herb known as a ringworm plant. Antioxidants protect the body against reactive oxygen species-induced oxidative damage, which is linked to cardiovascular disease and cancer. Naturally occurring plant antioxidants are being considered as preventive medicine. Escherichia coli, Staphylococcus aurteus, Enterococcus faecalis, and Bacillus subtilis were examined for Senna alata extract secondary metabolites, antioxidant, and antibacterial activity. The plant leaf was phytochemically examined for alkaloids, tannins, general glycosides, steroids, and terpenoids.

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Halim, Murni. "The PHYTOCHEMICALS, ANTIOXIDANT AND ANTIMICROBIAL PROPERTIES OF Senna alata AND Senna tora LEAF EXTRACTS AGAINST BACTERIAL STRAINS CAUSING SKIN INFECTIONS." Bacterial Empire 2, no. 1 (2019): 19. http://dx.doi.org/10.36547/be.2019.2.1.19-25.

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A study was carried out to screen for phytochemical constituents and assess the antioxidant and antimicrobial activities of Senna alata and Senna tora leaf extracts. The leaves were first dried at room temperature and 50°C in an oven prior to solvent extraction using ethanol and methanol. The in-vitro qualitative assays showed that both S. alata and S. tora leaf extracts contained bioactive and secondary metabolites components such as tannins, steroids, saponin, terpenoids, glycosides, flavonoids and phenols. The antioxidant activity and capacity test were carried out by conducting free radica

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Prince Cobbinah, John Doffour, Cosmas S. Abengmeneng, Ammal Abukari, and Latif Iddrisu Nasare. "Effect of antifungal botanical extracts on seed-borne fungi prevalence and germination of Terminalia ivorensis seeds in Ghana." Magna Scientia Advanced Biology and Pharmacy 10, no. 2 (2023): 068–79. http://dx.doi.org/10.30574/msabp.2023.10.2.0084.

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The use of synthetic fungicides for the management of seed-borne pathogens are detrimental to human health and the environment. In view of this research was conducted to assess the effect of antifungal botanical extracts (garlic, neem and Senna alata) on seed-borne fungi prevalence and seed germination of Terminalia ivorensis seeds. Two major seed-borne fungi of two genera namely Aspergillus niger and Colletotrichum sp. were isolated from the seeds. There was a hundred percent incidence of seed-borne fungi infection of Terminalia ivorensis seeds. Aspergillus niger was predominant with an incid

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Towanou, Rodrigue, Basile Konmy, Mahudro Yovo, et al. "Phytochemical Screening, Antioxidant Activity, and Acute Toxicity Evaluation of Senna italica Extract Used in Traditional Medicine." Journal of Toxicology 2023 (March 17, 2023): 1–10. http://dx.doi.org/10.1155/2023/6405415.

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Medicinal plants such as Senna italica are increasingly used for their purgative virtues to treat stomach aches, fever, and jaundice. This study aims to screen the phytochemical compounds and to assess the antioxidant activity in vitro and the acute oral toxicity in vivo of Senna italica leaves. The plant was harvested, dried, pulverized, and preserved. Phytochemical screening was performed using different laboratory protocols. Ethanolic and aqueous extracts were, respectively, obtained by maceration and decoction technics. The assay for free radical scavenging was used to examine the antioxid

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Zakari, S. M., A. A. Aliko, H. Haruna, and A. Muazu. "Evaluation of qualitative phytochemicals and antifungal activity of aqueous leaf extract of Senna tora on downy mildew of cabbage." Bayero Journal of Pure and Applied Sciences 11, no. 1 (2018): 15–19. http://dx.doi.org/10.4314/bajopas.v11i1.3.

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This study was embarked upon to evaluate the efficacy of aqueous extracts of Senna tora leaf against Perenospora parasitica, causing downy mildew on cabbage. Phytochemical analysis of the leaf extracts revealed the presence of some secondary metabolites (Tannins, Saponins, Flavonoid, Glycosides, Alkaloids, Phenolic compounds and Carbohydrates) which have been reported to have antimicrobial effects. Assays were performed using extract concentrations of 1000, 500, 250, 125 mg/ml by agar well diffusion technique. Results obtained, revealed a significant difference in diameter of mycelial zone of

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Mena-Rejóna, Gonzalo J., Karla Pérez-Rivas, Pablo Sansorez-Peraza, Tirso Rios, and Leovigildo Quijano. "Racemochrysone, a Dihydroanthracenone from Senna racemosa." Zeitschrift für Naturforschung C 57, no. 9-10 (2002): 777–79. http://dx.doi.org/10.1515/znc-2002-9-1003.

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From the hexane extract of the bark of the stems of Senna racemosa (syn. Cassia racemosa) a new dihydroanthracenone derivative, named racemochrysone, was isolated. Its structure was established as 8,9-dihydroxy-3-methoxy-2,2,6-trimethyl-(2H)-anthracen-1-one based on spectroscopical data, mainly 1D and 2D NMR experiments. In addition β-sitosterol, stigmasterol, chrysophanol and physcion were obtained. From the leaves extracts the piperidine alkaloid cassine and the hexitol pinitol were obtained.

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Ogunjinmi, Oluwasayo Esther, Olumayowa Vincent Oriyomi, and Adedoyin Adetutu Olasunkanmi. "Phytochemical, Antioxidant and Anti-diabetic Potentials of the Ethanol Leave Extracts of four Medicinal Plants." European Journal of Medicinal Plants 34, no. 5 (2023): 1–11. http://dx.doi.org/10.9734/ejmp/2023/v34i51135.

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For many years, medicinal plants have been a resource for healing in several local communities around the world and the phytochemicals in them such as flavonoids, alkaloids, phenolic, tannins, and terpenoids are attributed to their many medicinal values. Vernonia amydalina, Senna alata, Jatropha curcas, and Grewia pubescens are important plants with immense value. In this study, phytochemical screening, antioxidant analysis and the potential anti-hyperglycemic properties of the plants was investigated in-vitro. The ethanol leave extracts of the plants were subjected to qualitative phytochemica

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Adhikary, Megha Das, Bhaskar Narayan Chaudhuri, Partha Guchhait, and Satadal Das. "Antifungal Activities of Cassia angustifolia Leaf Ethanolic Extract against Various Candida Spp." Scholars Academic Journal of Biosciences 11, no. 07 (2023): 249–53. http://dx.doi.org/10.36347/sajb.2023.v11i07.004.

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Indian senna (Cassia angustifolia) is a perennial shrub belonging to the family Fabaceae. Indian senna contains flavonoids, pinnitolos (polyols), acidic polysaccharides, and mineral substances. It also contains two types of glucosides known as sennosides A and B and other compounds, including myricyl alcohol, anthraquinone derivatives, galactose, arabinose, rhamnose, galacturonic acid, chrysophanic acid, salicylic acid, resin, and mannitol. The antifungal activity of the extract was assessed against fungal strains, including Candida albicans (ATCC10231), Candida parapsilosis, and Candida auris

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Oliveira, Analú Barros de, Túlio Morandin Ferrisse, Sarah Raquel de Annunzio, et al. "In Vitro Evaluation of Photodynamic Activity of Plant Extracts from Senna Species against Microorganisms of Medical and Dental Interest." Pharmaceutics 15, no. 1 (2023): 181. http://dx.doi.org/10.3390/pharmaceutics15010181.

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Background: Bacterial resistance requires new treatments for infections. In this context, antimicrobial photodynamic therapy (aPDT) is an effective and promising option. Objectives: Three plant extracts (Senna splendida, Senna alata, and Senna macranthera) were evaluated as photosensitizers for aPDT. Methods: Cutibacterium acnes (ATCC 6919), Streptococcus mutans (ATCC 35668), Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and Candida albicans (ATCC 90028) were evaluated. Reactive oxygen species production was also verified. Oral keratinocytes assessed cytotoxicity. LC-DAD-M

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L. Javeres, Mbah N., Syed M. Nurulain, Oumarou G. Hamadama, Haris J. Bello, and Anas Muazu. "In vivo Anti-Plasmodium Activity and Toxicity of Afzelia bipindensis and Senna Siamea Extracts: A Murine Model." Open Medicinal Chemistry Journal 13, no. 1 (2019): 50–57. http://dx.doi.org/10.2174/1874104501913010050.

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Background: Malaria, a parasitosis affecting man, remains a public health problem in developing countries where morbidity and mortality are very high. Afzelia bipindensis and Senna siamea are two plants used in the treatment of malaria in different African countries including Cameroon. Objective: The aim of the present study was to evaluate the antiplasmodial activity of hydroethanolic leaves extracts of Afzelia bipindensis and Senna siamea, from Northern Cameron using Plasmodium berghei and to investigate the acute and sub-acute toxicity of leaves extracts in a rodent model. Methods: The four

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BOUBACAR, Rachida IBRAHIMA, Saley KARIM, Bahari KASSOUM DJATAOU, et al. "Détermination in vivo de l’effet anti-inflammatoire et de la toxicité des extraits des feuilles de Senna singueana (Del.) Lock." Journal of Applied Biosciences 182 (February 28, 2023): 19060–68. http://dx.doi.org/10.35759/jabs.182.7.

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Objectifs : le but de cette étude était de contribuer à la valorisation du potentiel thérapeutique de Senna singueana (Del.) Lock, (runhu, Haoussa Niger) une plante médicinale présente au Niger et possédant des nombreux usages médicaux par la détermination de l’activité anti-inflammatoire et la toxicité aiguë des extraits issus des feuilles de Senna singueana. Méthodologie et résultats : L’activité anti-inflammatoire a été déterminée en utilisant la méthode de l’œdème à la carraghénine et la méthode du granulome induit par la boulette de coton. Le test limite de la directives OCDE a été adopté

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Benoit, Onsiyor Effozougba Jean, Esse Sonia Estelle, Zahoui Ouga Stanislas, and Nene Bi Semi Anthelme. "Hypotensive Effect of an Aqueous Extract of Leaves of Senna alata (L.) ROXB (Caesalpiniaceae), a Plant Known to be Antihypertensive, in Rabbits." Scholars Academic Journal of Pharmacy 13, no. 09 (2024): 391–99. http://dx.doi.org/10.36347/sajp.2024.v13i09.003.

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The leaves of Senna alata (L.) ROXB (Caesalpiniaceae) are used in traditional African medicine mainly to treat arterial hypertension. The aim of the present study was to evaluate the hypotensive effects of an aqueous extract of leaves of Senna alata on arterial hypertension in rabbits. A qualitative phytochemical study was conducted to determine the various secondary compounds contained in this extract. Using a Ludwig manometer, consisting of a U-shaped tube containing mercury surmounted by a writing stylus, the blood pressure of rabbits was recorded on smoked paper wound around a cylinder rot

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Karki, Deepa, Bipindra Pandey, Prabhat Jha, et al. "Senna alata: Phytochemistry, Antioxidant, Thrombolytic, Anti-inflammatory, Cytotoxicity, Antibacterial activity, and GC-MS analysis." Jordan Journal of Pharmaceutical Sciences 17, no. 3 (2024): 549–66. http://dx.doi.org/10.35516/jjps.v17i3.2406.

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Objective: Nepal's medicinal herbs are rich in cultural importance and have several uses. Senna alata, a plant belonging to the Leguminosae family, is prized for its aesthetic and therapeutic qualities. The goal of the study was to extract Senna alata leaves using several solvent macerations. Methods: The study aims to evaluate the phytochemistry, total phenolic and flavonoid levels, antioxidant qualities in vitro, anti-inflammatory effects, cytotoxicity, anti-thrombolytic potential, and antibacterial activity, a variety of methodologies were employed. Results: The extractive values of Senna a

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Singh, Vijay Vikram, Jainendra Jain, and Arun Kumar Mishra. "Evaluation of Anticonvulsant and Antioxidant Activity of Senna occidentalis Seeds Extracts." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 183–87. http://dx.doi.org/10.22270/jddt.v9i2.2400.

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Aim: The aim of present work was to determine the anticonvulsant and antioxidant activity of Senna occidentalis L. ethanolic seed extract by different models. Methods: For evaluation of anticonvulsant activity, Pentylenetetrazole (PTZ) seizure model and Maximal electroshock (MES) seizure model were used. For antioxidant activity, (1, 1-diphenyl - 2-picryl hydrazine (DPPH) and hydrogen peroxide (H2O2) method were used. Results: The finding suggested that the ethanolic extract (EAE) of Senna occidentalis in the dose 400 mg/kg body weight posses potent anticonvulsant activity. The EAE showed ant

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Abddulmalik, Shehu, M. Tahir Tahir, Y. Sule Suleiman, A. Bashir Iliyasu, and M. Lawal Abubakar. "Phytochemical Analysis and Antioxidant Evaluation of Methanolic Extract of Senna occidentalis and Guiera senegalensis leaves." Chemistry Research Journal 4, no. 2 (2019): 185–92. https://doi.org/10.5281/zenodo.13370874.

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In the present study, the research is concerned with the extraction using soxhlet extraction technique in solvent with increasing polarity. The phytochemical constituents of <em>Senna occidentalis</em> and <em>Guiera senegalensis </em>were identified using various test methods and evaluates the antioxidant activity of methanolic extract of the plants leaves. The antioxidant activity of methanolic extract of both <em>Senna occidentalis</em> and <em>Guiera senegalensis</em> leaves were determined by DPPH (2,2-diphenyl-1-picrylhydrazine) free radical scavenging capacity with varying concetration.

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Aung, Wah Wah, Kanokpon Panich, Suchawalee Watthanophas, et al. "Preparation of Bioactive De-Chlorophyll Rhein-Rich Senna alata Extract." Antibiotics 12, no. 1 (2023): 181. http://dx.doi.org/10.3390/antibiotics12010181.

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Senna alata leaves display various biological activities as a result of their rhein and phenolic composition. The objective of this study was to develop bioactive de-chlorophyll rhein-rich S. alata extracts. The rhein content was quantified using a validated high-performance liquid chromatography–diode array detection (HPLC–DAD) method. The best process parameters for maximizing rhein were established using ultrasound-assisted extraction (UAE). The optimal conditions for the parameters were determined using the Box–Behnken design (BBD); 95% v/v ethanol was used as the extraction solvent at 59.

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Daskum, A. M., G. Chessed, M. A. Qadeer, and L. Y. Ling. "Phytochemical screening, Gas Chromatography Mass Spectroscopy (GC-MS) and in vitro antiplasmodial analysis of Senna siamea leaves as antimalarial, Yobe State, Nigeria." Nigerian Journal of Parasitology 41, no. 1 (2020): 60–67. http://dx.doi.org/10.4314/njpar.v41i1.10.

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Poverty and lack of access to health facilities had necessitated the less privileged to depend on herbal remedies to treat a number of diseases including malaria. The successes recorded from the discovery of novel antimalarials from plant sources had paved the way for the search of antimalarial compounds from traditional pharmacopeia. Phytochemical analysis as well as GC-MS analysis of crude leaves extract of Senna siamea was conducted, with a view to identifying compounds with biological activities. Further antimalarial assessment of the crude extracts was also performed in an in vitro assay.

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Mogaka, Simeon, Isaac Mulei, Peninah Njoki, et al. "Antimalarial Efficacy and Safety of Senna occidentalis (L.) Link Root Extract in Plasmodium berghei-Infected BALB/c Mice." BioMed Research International 2023 (August 7, 2023): 1–12. http://dx.doi.org/10.1155/2023/8296195.

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Background. Emergence of Plasmodium resistance to antimalarial drugs presents a major drawback in efforts to control malaria. To address this problem, there is an urgent and continuous need for the development of new and effective antimalarial agents. Senna occidentalis (L.) link extract has exhibited in vitro antiplasmodial activity in many pharmacological studies. To our knowledge, data on its in vivo antimalarial efficacy is still very limited. A recent study demonstrated that polar extracts from the plant roots inhibit Plasmodium berghei proliferation in a mouse model. This study further d

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Phuyal, Ashish, Manoj Poudel, Radha Bhandari, et al. "Phytochemical Composition and Corrosion Inhibitory Efficiency of Tinospora cordifolia and Senna alata Plant Extracts on Mild Steel in Acidic Media." Butwal Campus Journal 7, no. 2 (2024): 25–40. https://doi.org/10.3126/bcj.v7i2.73175.

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Tinospora cordifolia and Senna alata are well-known medicinal plants recognized for their extensive antibacterial, antifungal, and therapeutic applications. In addition to their well-established medicinal values they show great promise as eco-friendly corrosion inhibitors. In this study, plant extracts from Tinospora cordifolia and Senna alata were used as sustainable inhibitors to prevent the corrosion of mild steel in acidic environments. Plant extracts were prepared using the Soxhlet extraction technique with water, hexane, and methanol as solvents. Qualitative phytochemical analysis reveal

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Manimaran, Subramanian, Kadirvelmurugan Venkatachalam, Gandhimaniyan Krishnan, Ambedkar Govindasamy, and Vijayakumar Sakthivel. "ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF LEAF EXTRACTS OF SENNA TORA (L.) ROXB." International journal of multidisciplinary advanced scientific research and innovation 1, no. 10 (2021): 273–82. http://dx.doi.org/10.53633/ijmasri.2021.1.10.004.

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Plants have always been an important source of medicines since ancient times and seventy percent of the worldwide population still relies on one or other forms of traditional plant based medicine. Plant items have been essential for phytomedicines since days of yore. These can be derived from any part of the plants like bark, leaves, flowers, roots, fruits, seeds, etc. The present exploration has been conducted in the leaf of Senna tora performing various phytochemical tests to identify the secondary metabolites present in it such as alkaloids, flavonoids, sugars, glycosides, saponins, steroid

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Osman, Nadia Nour. "Role of Senna, Cassia angustifolia and Fennel, Foeniculum vulgare in Ameliorating Nephropathy in Diabetic Rats." Bioscience Biotechnology Research Communications 15, no. 1 (2022): 208–16. http://dx.doi.org/10.21786/bbrc/15.1.32.

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Diabetes mellitus is one of the most challenging metabolic pandemics that affect essential biochemical pathways in the body. The cost of Diabetes mellitus treatment and its side effects may call for an investigation on plant products as sources of treatment. Whereas, traditional medicine has proven that treatment with plant extracts is affordable, effective, and may have fewer negative effects than modern medicines. The current study aimed to investigate the renoprotective effects of senna (Cassia angustifolia) and fennel (Feoniculum vulgar) against streptozotocin-induced diabetes in albino ra

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Hendriyani, Irmatika, Meri Kartika Maulida, Abdul Rahman Wahid, Widayatul Khairi, and Taufan Hari Sugara. "ANTIOXIDANT ACTIVITY OF TEGINING GANANG (Senna hirsuta L) LEAF EXTRACT USING DPPH METHOD." Medical Sains : Jurnal Ilmiah Kefarmasian 10, no. 3 (2025): 263–72. https://doi.org/10.37874/ms.v10i3.1724.

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Tegining ganang (Senna hirsuta L) is a commodity plants on Lombok Island and is traditionally used to treat minor wounds, severe wounds, and skin infections. This study aimed to evaluate the antibacterial and antioxidant activities of ethanol, ethyl acetate, and n-hexane extracts of Tegining ganang leaves against Staphylococcus aureus and Escherichia coli using the DPPH method. The results showed that the ethyl acetate extract exhibited the highest antibacterial activity. Escherichia coli with an inhibition zone of 8.16 mm. For Staphylococcus aureus, the inhibition zone was 1.16 mm. However, a

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Musa, Aminu, Ibrahim Usman Gafai, and Asiya Junaid. "Green Synthesis of Copper Oxide Nanoparticles Using Senna Siamea Leaves Extract: Antibacterial Potential and Prospects for Sustainable Medical and Environmental Applications." International Journal of Scientific Research in Chemical Sciences 12, no. 1 (2025): 33–39. https://doi.org/10.26438/ijsrcs.v12i1.185.

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Nanoparticles have garnered significant attention due to their diverse applications in medicine, engineering, and environmental science. However, the chemical synthesis of nanoparticles often involves significant costs and environmental hazards due to the release of toxic byproducts. To address these challenges, we examined the environmentally sustainable and cost-effective biosynthesis of copper oxide nanoparticles (CuONPs) using Senna siamea leaf extract as a bioreducing agent. This research entailed the synthesis of copper oxide nanoparticles from copper sulfate (CuSO₄) in an aqueous soluti

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M. A., Essien-Ibok,, George, U. U., Ajayi, O. O., and Okokon, P. "Investigating the Impact of Senna alata Extract on Hematology and Histopathology of Juvenile of Clarias gariepinus." Asian Journal of Environment & Ecology 23, no. 8 (2024): 74–85. http://dx.doi.org/10.9734/ajee/2024/v23i8585.

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This paper sheds light on the mechanism of action, potential effects and implication of Senna alata on fish health and ecosystem. Senna alata is renowned for its medicinal properties and ornamental value but is also recognized for its potential toxicity, particularly to aquatic organisms Understanding the toxicity of Senna alata to Clarias gariepinus fingerlings is essential for sustainable aquaculture practices and environmental conservation efforts. 250 juveniles of C. gariepinus were procured from E. I farm Limited in Ikot Ekpene, Akwa Ibom State. Water quality tests were carried out to ens

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M.B., Shreya, Neeraja K., Subhankar Das, Sadhana Sundararajan, and Rajiniraja Muniyan. "In vitro anti-mycobacterial property and phytochemical profiling of Senna auriculata and Trachyspermum copticum." Research Journal of Biotechnology 18, no. 10 (2023): 9–16. http://dx.doi.org/10.25303/1810rjbt09016.

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Mycobacterium tuberculosis is a contagious disease that is the leading cause of death by a single causative organism. The present study aims to investigate and assess the anti-mycobacterial property of some traditionally important medicinal plants and analyze their phytochemical constitution. The extracts of some plants based on their medicinal importance were checked for their activity against M. smegmatis using anti-mycobacterial disc diffusion plate assay. Aqueous extracts of Senna auriculata, Trachyspermum copticum and Musa spp. were tested against M. smegmatis. Further Senna auriculata an

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Al-Rejaboo, Maha Akram, Zakaria Sami Almola, and Mohammad Abdullah Almashhadani. "<i>In vitro</i> the effect of ethanol extracts of <i>Senna alexandrina</i> and <i>Achillea millefolium</i> on fungi pathogenic to plants and humans." Journal of Applied and Natural Science 16, no. 4 (2024): 1444–55. https://doi.org/10.31018/jans.v16i4.5852.

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Plant extracts are natural sources of bioactive compounds that could be used for crop protection and preserving human health. The present study aimed to evaluate the impact of ethanolic extracts of Senna alexandrina leaves and Achillea millefolium flowers on the growth of some filamentous fungi and yeasts isolated from yellow corn and human. Alcoholic extract of Achillea millefolium flowers showed significant inhibitory effects against the filamentous fungi: Aspergillus flavus, A. ustus, Cladosporium oxysporum, Fusarium graminearum and Penicillium citrinum, beside the dermatophytes Trichophyto

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Zakaria, Nik Hasanah, ,. Mohd Dasuki Sul’ain, and Wan-Nor-Amilah Wan Abdul Wahab. "Antimicrobial Activity and Prebiotic Effects of Senna alata Leaf Extracts." Asian Journal of Medicine and Biomedicine 6, S1 (2022): 166–68. http://dx.doi.org/10.37231/ajmb.2022.6.s1.574.

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Medicinal plants are a great source of antibacterial and prebiotic properties that can treat a wide range of human diseases. Senna alata, also known as "candle bush," has many health benefits. It has antimicrobial properties and has been used for centuries to treat skin infections [1] and digestion-related problems such as constipation, stomach discomfort, and liver diseases [2]. This study aimed to screen the phytoconstituents of S. alata leaf extracts, study their antimicrobial activity against several intestinal pathogens, and investigate their potential prebiotic effects against a few prob

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Moosaripparambil, Shiji Thozhukkad, and Kannan Vadakkadath Meethal. "Assessment of Cytotoxic Effects of Plant Protease Inhibitors on Cancerous Cell Lines." UTTAR PRADESH JOURNAL OF ZOOLOGY 45, no. 14 (2024): 183–94. http://dx.doi.org/10.56557/upjoz/2024/v45i144194.

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Protease inhibitors, whether natural or synthetic, show promise in cancer treatment by targeting dysregulated proteolytic activity linked to tumor progression and metastasis. This study evaluated trypsin inhibitory activity and cytotoxic effects of selected plant extracts. Screening twenty-six plant extracts revealed twelve extracts contain trypsin inhibitors, and eighteen plant extracts showed cytotoxicity to the HT29 cell line, with the highest cytotoxicity shown by Senna alatta extract (98.45 ± 0.44 %). When plant extracts containing protease inhibitors were subjected to proteinase K digest

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Ejeh Yakubu, Ojochenemi, Mubarak Sanusi Tani, Onuh Gabriel Emmanuel, Caleb Enejoh Omede, and Janya Danjuma. "Kidney Function Status of Diabetic Male Wistar Albino Rat Treated with Senna tora Extract." International Journal of Current Microbiology and Applied Sciences 13, no. 7 (2024): 205–11. http://dx.doi.org/10.20546/ijcmas.2024.1307.021.

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The kidney plays a central role in detoxification and excretion of harmful metabolites and therefore is susceptible to toxicity by xenobiotics. The main goal of this study is to analyze the kidney function status of diabetic Male Wistar albino rat treated with Senna tora extract. Samples of matured and healthy-looking leaves of Senna tora were collected from the school environment, Federal University Wukari, Taraba State, Nigeria. Extraction of the plant was done using absolute ethanol and fractionation with different solvents of varied polarity via separating funnel, starting from ethanol, n-

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Vishwakarma, Shubhangi, and Mansi Gupta. "Formulation and Evaluation of Antifungal Herbal Gel Containing Ethanolic Extract of Senna Alata, Murraya Koenigii and Aloe Vera." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 518–22. http://dx.doi.org/10.22270/jddt.v9i4.3095.

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Herbal medicines is still the mainstay of about 75-80% of the world’s population, mainly in developing countries, for primary health care because of better cultural acceptability, better compatibility with human body and lesser side effects. Herbal medicines consist of plant or its part to treat injuries, disease or illnesses and are used to prevent and treat diseases and ailments or to promote health and healing. it is a drug or preparation made from a plant or plants and used for any to such purpose. The aim of present study was to prepare herbal gel formulation containing ethanolic extract

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Alkali K., Dikwa K. B., G. A. Ajibade, Y. Magaji, and Abdulhamid M.B. "Qualitative and Quantitative Phytochemicals Screening of Aqueous, Methanol and Hexane Leaves Extracts of Senna Occidentalis." Asian Plant Research Journal 12, no. 3 (2024): 27–35. http://dx.doi.org/10.9734/aprj/2024/v12i3250.

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The Senna occidentalis tree is an incredible plant with incredible antimicrobial, antifungal and antimalarial activities used traditionally. The study was carried out to determine the phytochemical content responsible for these activities Fresh leaves were collected, aqueous, methanolic and hexane extracts of leaves were prepared, and the extracts were screened for phytochemical constituents using standard methods. Results of the phytochemical screening of all the crude extracts revealed the presence of saponins, tannins, steroids, phenol, alkaloid and flavonoid. In aqeuose extract, flavonoid

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