Academic literature on the topic 'Sensibilisation de lymphocytes T in vitro'
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Journal articles on the topic "Sensibilisation de lymphocytes T in vitro"
Pawelec, Graham, Medi Adibzadeh, Arnika Rehbein, Karin Hähnel, Wolfgang Wagner, and Andrea Engel. "In vitro senescence models for human T lymphocytes." Vaccine 18, no. 16 (February 2000): 1666–74. http://dx.doi.org/10.1016/s0264-410x(99)00504-6.
Full textHorwood, Nicole J., Vicky Kartsogiannis, Julian M. W. Quinn, Evangelos Romas, T. John Martin, and Matthew T. Gillespie. "Activated T Lymphocytes Support Osteoclast Formation in Vitro." Biochemical and Biophysical Research Communications 265, no. 1 (November 1999): 144–50. http://dx.doi.org/10.1006/bbrc.1999.1623.
Full textMackova, J., K. Zurkova, V. Sroller, J. Musil, K. Babiarova, and S. Nemeckova. "In vitro generation of CMV specific T-lymphocytes." Journal of Clinical Virology 70 (September 2015): S116. http://dx.doi.org/10.1016/j.jcv.2015.07.269.
Full textHOFFMAN, ROSEMARY A., BONNIE J. HYLAND, NANCY L. ASCHER, and RICHARD L. SIMMONS. "THE MIGRATION OF ACTIVATED T LYMPHOCYTES IN VITRO." Transplantation 41, no. 2 (February 1986): 214–19. http://dx.doi.org/10.1097/00007890-198602000-00016.
Full textChung, Mi-Kyung, Heesik Yoon, Sung-Shik Min, Hee Gu Lee, Young Jae Kim, Tae Gyu Lee, Jong Soon Lim, Chang Min Kim, and Sue Nie Park. "Induction of Cytotoxic T Lymphocytes with Peptides In Vitro." Journal of Immunotherapy 22, no. 4 (July 1999): 279–87. http://dx.doi.org/10.1097/00002371-199907000-00001.
Full textHerry, I., M. Bonay, F. Bouchonnet, M. P. Schuller, D. Lecossier, A. Tazi, D. H. Lynch, and A. J. Hance. "Extensive apoptosis of lung T-lymphocytes maintained in vitro." American Journal of Respiratory Cell and Molecular Biology 15, no. 3 (September 1996): 339–47. http://dx.doi.org/10.1165/ajrcmb.15.3.8810637.
Full textBruserud, Øystein. "Dipyridamol inhibits activation of human T lymphocytes in vitro." Clinical Immunology and Immunopathology 42, no. 1 (January 1987): 102–9. http://dx.doi.org/10.1016/0090-1229(87)90177-2.
Full textHaranaga, Shusaku, Hiroyuki Yamaguchi, Herman Friedman, Shin-ichi Izumi, and Yoshimasa Yamamoto. "Chlamydia pneumoniae Infects and Multiplies in Lymphocytes In Vitro." Infection and Immunity 69, no. 12 (December 1, 2001): 7753–59. http://dx.doi.org/10.1128/iai.69.12.7753-7759.2001.
Full textDiel, F., B. Horr, H. Borck, H. Savtchenko, T. Mitsche, and E. Diel. "Pyrethroids and piperonyl-butoxide affect human T-lymphocytes in vitro." Toxicology Letters 107, no. 1-3 (June 1999): 65–74. http://dx.doi.org/10.1016/s0378-4274(99)00032-6.
Full textKaltoft, Keld. "Cytokine-Driven Immortalization of in vitro Activated Human T Lymphocytes." Experimental and Clinical Immunogenetics 15, no. 2 (1998): 84–89. http://dx.doi.org/10.1159/000019058.
Full textDissertations / Theses on the topic "Sensibilisation de lymphocytes T in vitro"
Garrigue, Jean-Luc. "Méthodes alternatives et sensibilisation cutanée : développement d'un modèle murin d'eczéma de contact aux haptènes forts et faibles in vivo et in vitro." Lyon 1, 1994. http://www.theses.fr/1994LYO1T102.
Full textHuppert, Cécile. "Développement d’un modèle de coculture cellules dendritiques lymphocytes T pour l’évaluation du danger des substances sensibilisantes." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0195/document.
Full textAllergies constitute an important issue in the field of occupational health and have a serious impact on the lives of workers. Occupational allergies are mainly contact and respiratory allergies and can be caused by low molecular weight chemicals. In the past, the tests that were used to identify the potential allergens were carried out on animals. However, European legislation has provided the impetus for reducing the use of animal testing to assess the sensitization potential of chemicals and promoted the development of alternative in vitro tests. In this context, we aimed to develop cell culture models to identify sensitizers. A first model using bone marrow derived dendritic cells (BMDC) from BALB/c mice was developed and showed promising results for identifying sensitizers and classify them according to their allergenic potency. Moreover, the Nrf2/Keap1 pathway seems to be involved in the response of this cell model to sensitizers. In order to supplement this model and to assess the functionality of BMDC, a BMDC-T cell (TC) coculture model was developed with a reference sensitizer before being tested on a range of reference sensitizers (cutaneous and respiratory sensitizers, irritants and non-sensitizers). The BMDC of our model, while exposed to sensitizers, were able to activate TC in coculture. Finally, preliminary tests using the cells of C57BL6/J mice in our coculture model showed that similar results to those obtained with cells from the BALB/c strain. The models of BMDC cultures and BMDC-TC coculture are promising for the development of alternative methods to animal experimentation assessing the sensitizing potential of chemicals
Conche, Claire. "Mécanismes Moléculaires impliqués dans la sensibilisation des lymphocytes T par l'adhérence." Paris 7, 2009. http://www.theses.fr/2009PA077092.
Full textT cells are major effector of immune System that defend us against pathogens and cancer. Naive T cells navigate from blood and lymph vessels where they are in suspension, to lymph node where they are adherent and encounter dendritics cells (DC). The multiplicity of the T/DC contacts decreases the threshold of T celKactivation. This phenomenon called adhesion-induced T cell priming (AITCP) was discovered in the team. AITCP is associated with a larger calcium response to TCR-stimulation in adherent cells. The aim of the work presented here, was to investigate molecular mechanisms involved in this priming. We demonstrated that adhesion on fibronectin or DC induces a transient cAMP increase which is crucial for AITCP. The fînding was unexpected as a sustained cAMP rise is well known for its inhibitory effect on T cell activation. The priming effect of cAMP was due to an indirect activation of ERK after HePTP phosphatase inhibition. The second part of this work is focused on the PIP2 increase upon adhesion. We showed that PIP2 increase resulted from an activation of PIP5K that produces PIP2 and from an inhibition of PLCp that hydrolyses the PIP2. PLCp inhibition leads to an increase of calcium stores content. The exact functions of in AITCP are still under investigation
Luo, Xuan. "In vitro quantitative study of T cell adhesive haptotaxis." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0151/document.
Full textAn efficient immune response relies on a rapid recruitment of leukocytes from blood to the inflamed or damaged tissue. During this process, leukocytes are captured by the endothelium and migrate along the vessel wall to reach permissive transmigration sites. These processes are mediated by multiple external cues among which the role of adhesion molecules remains unclear. Adhesive haptotaxis has been described for mesenchymal cells that develop strong pulling forces with their substrates and orient via a tug of war mechanism – a competition between cells’ adherent pulling edges. In the case of amoeboid cells that migrate with minimal interaction with their substrate, the existence of adhesive haptotaxis has yet to be evidenced. Here, we studied the crawling of human T lymphocytes on substrates with spatially modulated adhesion. and observed robust adhesive haptotaxis. Mechanistically, we show that integrin-mediated adhesive haptotaxis of lymphocytes differs both from active chemotaxis, because no mechanotransduction was detected, and from the passive tug of war mechanism, because different integrins support opposite phenotypes. Cells favored more adherent zones with VLA-4 and, counterintuitively, less adherent zones with LFA-1. These results reveal that integrins control differential adhesive haptotaxis behaviors without mechanotransduction. We further investigated the mechanism behind this specific haptotactic phenotype mediated by LFA-1 and find that the lamellipodial dynamics, rather than the integrin expression level, is involved. Preliminary findings with VASP deficient T cells indicate also that VASP protein may play an important role in T cell adhesive haptotaxis
Renard, Nathalie. "Étude in vitro du rôle des lymphocytes T sur la lymphopoïèse B humaine." Lyon 1, 1996. http://www.theses.fr/1996LYO1T008.
Full textSerre, Karine. "Présentation d'antigènes exogènes par les cellules dendritiques, aux lymphocytes T CD4 et aux lymphocytes T CD8, in vitro et in vivo." Aix-Marseille 2, 2002. http://www.theses.fr/2002AIX22003.
Full textMontpellier, Claire. "Transformation in vitro de lymphocytes t humains par le virus d'epstein barr." Paris 6, 1997. http://www.theses.fr/1997PA066141.
Full textWoods, Margaret Annaliese. "Molecular mechanisms of action of therapeutic monoclonal antibodies on T lymphocytes in vitro." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627301.
Full textCognot, Chantal. "Structures particulières engendrant des lymphocytes T cytotoxiques : étude de la réponse primaire in vitro." Montpellier 1, 1986. http://www.theses.fr/1986MON13511.
Full textLiamin, Marie. "Exposition in vitro de lymphocytes T humains aux hydrocarbures aromatiques polycycliques : étude des effets immunotoxiques." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B060/document.
Full textPolycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (B[a]P), are ubiquitous environmental contaminants generated during organic matter combustion. These compounds have been associated with the development of toxic effects on human health, including carcinogenic and immunotoxic effects, mainly related to Aryl hydrocarbon Receptor (AhR) activation. Among the immune system cells, T lymphocytes appear as major targets of PAHs. Previous results, obtained in the laboratory, have shown that activation of primary human T lymphocytes leads to a functional AhR expression increase, suggesting their ability to respond to PAH exposure. Our specific aims are: (1) to determine the effects of B[a]P on gene expression profiles in human normal lymphocytes by using large-scale approaches such as microarray-based transcriptome analysis, (2) to monitor the genotoxic and immunotoxic effects of B[a]P by measuring DNA damage and immunosuppressive actions, respectively and, (3) to analyze the modulation of these effects by the presence of other PAHs. Our work propose primary cultures of activated human T lymphocytes as a good model for studying both genotoxic and immunotoxic effects of environmental contaminants such as PAHs and predicting human health issues. It also gains a comprehensive insight into the immune response regulation after PAH exposure and provides potential new biomarkers of exposure to these environmental contaminants
Books on the topic "Sensibilisation de lymphocytes T in vitro"
Jo, Euijung. An attempt to specifically immunosuppress anti-myelin basic protein T lymphocytes in vitro. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1993.
Find full textBishop, Dennis Keith. Influence of in vitro stimulation on T lymphocyte subset involvement in adoptive anti-Listeria immunity. 1986.
Find full textGravelle, Micheline Louise *. The targeting of CD4 r T lymphocytes to a B cell lymphoma: acomparison of two in vitro immunotherapeutic strategies. 1989.
Find full textBook chapters on the topic "Sensibilisation de lymphocytes T in vitro"
McLean, Angela R. "Modelling T Cell Memory in Vivo and in Vitro." In T Lymphocytes, 227–34. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3054-1_24.
Full textGigante, Margherita, and Elena Ranieri. "In Vitro\Ex Vivo Generation of Cytotoxic T Lymphocytes." In Methods in Molecular Biology, 13–20. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1158-5_2.
Full textAlam, S., Y. Katakura, H. Yoshida, S. Shirahata, and H. Murakami. "In Vitro Immortalization of Human T Lymphocytes by Oncogenes." In Animal Cell Technology: Basic & Applied Aspects, 645–49. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5746-9_105.
Full textKesisoglou, A., Jonathan C. Knowles, and I. Olsen. "Effects of Ca-Containing Phosphate Glasses on T Lymphocytes In Vitro." In Bioceramics 17, 597–602. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-961-x.597.
Full textVocanson, Marc, Amine Achachi, Virginie Mutez, Magalie Cluzel-Tailhardat, Béatrice Le Varlet, Aurore Rozières, Philippe Fournier, and Jean-François Nicolas. "Human T Cell Priming Assay: Depletion of Peripheral Blood Lymphocytes in CD25+ Cells Improves the In Vitro Detection of Weak Allergen-Specific T Cells." In T Lymphocytes as Tools in Diagnostics and Immunotoxicology, 89–100. Basel: Springer Basel, 2013. http://dx.doi.org/10.1007/978-3-0348-0726-5_7.
Full textGasparini, Anna, Laura Chiarantini, Heinz Kirch, and John R. DeLoach. "In Vitro Targeting of Doxorubicin Loaded Canine Erythrocytes to Cytotoxic T-Lymphocytes (CTLL)." In The Use of Resealed Erythrocytes as Carriers and Bioreactors, 291–97. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3030-5_35.
Full textDenegri, Jorge F., and Jeanne Peterson. "In Vitro Lymphocyte Priming, Clonal Selection, and Response to Third-Party Lymphocytes by VG01+ and VG01− T Cell Fractions." In Immunobiology of HLA, 504–5. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-662-39946-0_215.
Full textIshihara, Toshiki, and C. Garrison Fathman. "Production of antibodies in vitro in cultures of murine lymphocytes." In Immunochemical Techniques Part K: In Vitro Models of B and T Cell Functions and Lymphoid Cell Receptors, 304–9. Elsevier, 1987. http://dx.doi.org/10.1016/0076-6879(87)50087-8.
Full textVischer, Thomas L. "Stimulation of lymphocytes with proteolytic enzymes." In Immunochemical Techniques Part K: In Vitro Models of B and T Cell Functions and Lymphoid Cell Receptors, 109–12. Elsevier, 1987. http://dx.doi.org/10.1016/0076-6879(87)50070-2.
Full textKirchner, H., and Margarita Salas. "Stimulation of lymphocytes with zinc ions." In Immunochemical Techniques Part K: In Vitro Models of B and T Cell Functions and Lymphoid Cell Receptors, 112–17. Elsevier, 1987. http://dx.doi.org/10.1016/0076-6879(87)50071-4.
Full textConference papers on the topic "Sensibilisation de lymphocytes T in vitro"
Hunt, David W. C., Huijun Jiang, Ruth A. Salmon, David J. Granville, John R. North, and Anna M. Richter. "Action of the photosensitizer QLT0074 upon human T lymphocytes in vitro." In BiOS 2001 The International Symposium on Biomedical Optics, edited by Thomas J. Dougherty. SPIE, 2001. http://dx.doi.org/10.1117/12.424443.
Full textQi, Shuhong, and Zhihong Zhang. "Dynamic visualization the whole process of cytotoxic T lymphocytes killing the B16 tumor cells in vitro." In SPIE BiOS, edited by Wei R. Chen. SPIE, 2016. http://dx.doi.org/10.1117/12.2214268.
Full textAckroyd, James, Joanne Berry, Yaoyao Fu, Jason Allen, Martin Barnes, Alexander Patterson, Angelo Kaplan, et al. "Abstract 3715: Analysis of tumor infiltrating lymphocytes and in vitro exhausted T-cell models to identify unique Immuno-Oncology targets." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3715.
Full textReports on the topic "Sensibilisation de lymphocytes T in vitro"
Albertini, R. J. The development of in vitro mutagenicity testing systems using t-lymphocytes. Office of Scientific and Technical Information (OSTI), February 1998. http://dx.doi.org/10.2172/615639.
Full textAlbertini, R. J. The development of in vitro mutagenicity testing systems using T-lymphocytes. Office of Scientific and Technical Information (OSTI), May 1993. http://dx.doi.org/10.2172/6238540.
Full textAlbertini, R. J. The development of in vitro mutagenicity testing systems using T-lymphocytes. Office of Scientific and Technical Information (OSTI), May 1992. http://dx.doi.org/10.2172/7049865.
Full textAlbertini, R. J. The development of in vitro mutagenicity testing systems using T-lymphocytes. Research progress report, November 1, 1989--April 30, 1992. Office of Scientific and Technical Information (OSTI), May 1992. http://dx.doi.org/10.2172/10154144.
Full textAlbertini, R. J. The development of in vitro mutagenicity testing systems using T-lymphocytes. Research progress report, November 1, 1992--October 31, 1993. Office of Scientific and Technical Information (OSTI), May 1993. http://dx.doi.org/10.2172/10159768.
Full textAlbertini, R. J. The development of in vitro mutagenicity testing systems using T-lymphocytes: Research progress report: June 1, 1988--May 31, 1989. Office of Scientific and Technical Information (OSTI), May 1989. http://dx.doi.org/10.2172/6098183.
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