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Journal articles on the topic 'Sensititre™'

Author: Grafiati

Published: 15 June 2021

Last updated: 29 July 2025

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1

Aytaç, Özlem, Pınar Öner, Feray Ferda Senol, and Zülal Asçı-Toraman. "Comparison of Colistin Resistance Results of Multiple Resistant Clinical Acinetobacter baumannii Isolates with broth Microdilution, Sensititre, and Two Different Automated Systems." Klimik Dergisi/Klimik Journal 35, no. 3 (2022): 159–63. http://dx.doi.org/10.36519/kd.2022.4092.

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Objectives: Although the broth microdilution method (BMD) is recommended in determining colistin resistance, the search for alternative methods continues. We aimed to determine the effectiveness in detecting colistin sensitivity by comparing the liquid microdilution method, which is the gold standard method for colistin susceptibility testing, and the Sensititre™ microdilution (Thermo Fisher Scientific, MA, USA), Phoenix™ 100 (Becton Dickinson, USA), and MicroScan WalkAway™ (Beckman Coulter, USA) automated systems, which are the commercial BMD methods. Methods: For this purpose, 100 multidrug

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van Hout, Denise, Axel B. Janssen, Rob J. Rentenaar, Judith P. M. Vlooswijk, C. H. Edwin Boel, and Marc J. M. Bonten. "The added value of the selective SuperPolymyxin™ medium in detecting rectal carriage of Gram-negative bacteria with acquired colistin resistance in intensive care unit patients receiving selective digestive decontamination." European Journal of Clinical Microbiology & Infectious Diseases 39, no. 2 (2019): 265–71. http://dx.doi.org/10.1007/s10096-019-03718-5.

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Abstract The objective of this study was to determine the value of using SuperPolymyxin™ selective medium (ELITech Group, Puteaux, France) in addition to conventional non-selective inoculation methods in the detection of acquired colistin resistance in a Dutch intensive care unit (ICU) that routinely uses selective decontamination of the digestive tract (SDD). We performed a cross-sectional study with prospective data collection in a tertiary-care ICU. All consecutive surveillance rectal swabs of ICU-patients receiving SDD were included and cultured in an observer-blinded approach using (1) a

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Batista, Sara, Mariana Fernández-Pittol, Lorena San Nicolás, et al. "Design and Validation of a Simplified Method to Determine Minimum Bactericidal Concentration in Nontuberculous Mycobacteria." Antibiotics 14, no. 4 (2025): 381. https://doi.org/10.3390/antibiotics14040381.

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Background/Objectives: Nontuberculous mycobacteria (NTM) infections are rising, particularly those by Mycobacterium avium complex (MAC) and Mycobacterium abscessus complex (MAB). Treating NTM infections is challenging due to their poor response to antibiotics. This study aimed to optimize the treatment of NTM infection by selecting antibiotics with bactericidal activity for combination therapy. To do this, we used the minimum bactericidal concentration (MBC) determination approach to define bactericidal or bacteriostatic activity. We developed three main objectives: validate a new method to de

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Jones, Ronald N., Nicole M. Holliday, and Ian A. Critchley. "Accuracy of the Thermo Fisher Scientific (Sensititre™) dry-form broth microdilution MIC product when testing ceftaroline." Diagnostic Microbiology and Infectious Disease 81, no. 4 (2015): 280–82. http://dx.doi.org/10.1016/j.diagmicrobio.2014.12.010.

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Giordano, Cesira, Elena Piccoli, Veronica Brucculeri, and Simona Barnini. "A Prospective Evaluation of Two Rapid Phenotypical Antimicrobial Susceptibility Technologies for the Diagnostic Stewardship of Sepsis." BioMed Research International 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/6976923.

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Rapid identification of bloodstream pathogens by MALDI-TOF MS and the recently introduced rapid antimicrobial susceptibility testing (rAST) directly from positive blood cultures allow clinicians to promptly achieve a targeted therapy, especially for multidrug resistant microorganisms. In the present study, we propose a comparison between phenotypical rASTs performed in light-scattering technology (Alfred 60AST, Alifax®) and fluorescencein situhybridization (Pheno™, Accelerate) directly from positive blood cultures, providing results in 4–7 hours. Blood samples from 67 patients admitted to the

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Oganesyan, Ellina, Victoria Klimenteva, Irina Vybornova, et al. "Population Structure Based on Microsatellite Length Polymorphism, Antifungal Susceptibility Profile, and Enzymatic Activity of Candida auris Clinical Isolates in Russia." Journal of Fungi 11, no. 1 (2025): 35. https://doi.org/10.3390/jof11010035.

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Candida auris is an emerging multidrug-resistant fungal pathogen causing nosocomial transmission and invasive infections with high mortality. This study aimed to investigate the genetic relationships, enzymatic activities, and drug-resistance profiles of C. auris isolates to evaluate the population and epidemiological diversity of candidiasis in Russia. A total of 112 clinical isolates of C. auris were analyzed from May 2017 to March 2023 in 18 hospitals across Saint Petersburg, the Leningrad Region, and Moscow. Species identification was confirmed by ITS sequencing, and genotyping was perform

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Cherkaoui, Abdessalam, Adrien Fischer, Nouria Azam, Arnaud Riat, and Jacques Schrenzel. "A comparison of Sensititre™ Anaerobe MIC plate with ATB ANA® test for the routine susceptibility testing of common anaerobe pathogens." European Journal of Clinical Microbiology & Infectious Diseases 37, no. 12 (2018): 2279–84. http://dx.doi.org/10.1007/s10096-018-3369-5.

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Betiku, Eniola, Philip Glen Crandall, and Tomi Obe. "Microbial Assessment and Antibiotic Susceptibility of Isolated Pathogens in Retail Chicken." Foods 14, no. 10 (2025): 1738. https://doi.org/10.3390/foods14101738.

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Poultry is U.S. consumers’ protein of choice with an annual consumption of nearly 45 kg per person. This increasing demand has required poultry producers to minimize pathogen contamination to protect public health. This study assessed Salmonella and Campylobacter incidence and loads in retail chicken from conventional (CON) and raised without antibiotics (RWA) sources, while profiling antibiotic resistance of selected isolates. A total of 170 chicken samples from two brands (A and B), including whole carcass WOG (60), parts (80), and giblets (30) were evaluated. Both pathogens were examined by

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Demir-Çuha, Mervenur, and Gulsen Hazırolan. "Comparison of MIC COL, Sensititre™ and Colistin Agar Screening Plate Methods with Broth Microdilution Reference Method for Detection of Colistin Susceptibility in Carbapenem-Resistant Gram-negative Bacteria." Klimik Dergisi/Klimik Journal 34, no. 3 (2021): 186–91. http://dx.doi.org/10.36519/kd.2021.3857.

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Navas, Daniel, Angela Charles, Amy Carr, and Jose Alexander. "1280. In-Vitro Activity of Cefiderocol, Imipenem/Relebactam, & Ceftazidime/Avibactam in Ceftolozane/Tazobactam Resistant Strains of Multidrug Resistant Pseudomonas aeruginosa." Open Forum Infectious Diseases 7, Supplement_1 (2020): S655. http://dx.doi.org/10.1093/ofid/ofaa439.1463.

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Abstract Background The activity of imipenem/relebactam (I/R), ceftazidime/avibactam (CZA) and cefiderocol (FDC) were evaluated against clinical isolates of multidrug resistant (MDR) strains of P. aeruginosa which was resistant to ceftolozane/tazobactam (C/T). The recent increase of MDR P. aeruginosa strains isolated from clinical samples has prompted research and development of new antimicrobials that can withstand its multiple resistance mechanisms. C/T is an effective option for treatment of MDR P. aeruginosa in our facility with only 10% of resistance in MDR strains, but the emergence of r

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Rauseo, Adriana M., Margaret A. Olsen, Lindsey Larson, et al. "168. Creation and Internal Validation of a Clinical Predictive Model for Fluconazole Resistance in Patients with Candida Bloodstream Infection." Open Forum Infectious Diseases 7, Supplement_1 (2020): S91—S92. http://dx.doi.org/10.1093/ofid/ofaa439.212.

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Abstract Background IDSA guidelines on candidemia recommend fluconazole as first-line therapy in patients considered low risk for fluconazole resistant infections. However, there is currently no mechanism to determine risk of resistance, and most community hospitals cannot perform rapid sensitivity testing, leading to prolonged use of echinocandin therapy. This study aims to develop a clinical predictive model to identify patients at low risk for fluconazole resistance where first-line use of fluconazole therapy would be acceptable without requiring resistance testing. Methods We performed a r

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Getahun, Muluwork, Henry M. Blumberg, Gobena Ameni, Dereje Beyene, and Russell R. Kempker. "Minimum inhibitory concentrations of rifampin and isoniazid among multidrug and isoniazid resistant Mycobacterium tuberculosis in Ethiopia." PLOS ONE 17, no. 9 (2022): e0274426. http://dx.doi.org/10.1371/journal.pone.0274426.

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Introduction Traditionally, single critical concentrations of drugs are utilized for Mycobacterium tuberculosis (Mtb) drug susceptibility testing (DST); however, the level of drug resistance can impact treatment choices and outcomes. Mutations at the katG gene are the major genetic mutations in multidrug resistant (MDR) Mtb and usually associated with high level resistance. We assessed the minimum inhibitory concentrations (MICs) of MDR or rifampin resistant (RR) and isoniazid (INH) resistant Mtb isolates to determine the quantification of drug resistance among key anti-tuberculosis drugs. Met

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Tantisiriwat, Woraphot, Jirawat Buppanharun, Chatchai Ekpanyaskul, et al. "In Vitro Activity of Ceftolozane-Tazobactam and Other Antibiotics against Pseudomonas aeruginosa Infection-Isolates from an Academic Medical Center in Thailand." Antibiotics 11, no. 6 (2022): 732. http://dx.doi.org/10.3390/antibiotics11060732.

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(1) Background: Resistant Pseudomonas aeruginosa (PA) infections have limited treatment options. Data on the activity of ceftolozane-tazobactam (C-T) against PA in Thailand are limited. Objectives: The objective of this study was to identify the in vitro activity of C-T against general and resistant PA isolates from patients with real clinical infections from the HRH Princess Maha Chakri Sirindhorn Medical Center (MSMC) compared to other antibiotics and to study the resistant molecular patterns of those PA strains which were resistant to C-T. (2) Materials and Methods: This was an in vitro sus

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Yusuf, Erlangga, Mireille van Westreenen, Wil Goessens, and Peter Croughs. "The accuracy of four commercial broth microdilution tests in the determination of the minimum inhibitory concentration of colistin." Annals of Clinical Microbiology and Antimicrobials 19, no. 1 (2020). http://dx.doi.org/10.1186/s12941-020-00383-x.

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Abstract Colistin is considered as one of the last-resort antibiotics and reliable antimicrobial susceptibility testing is therefore crucial. The reference standard for AST according to EUCAST and CLSI is broth microdilution (BMD). However, BMD is labor intensive to perform. Commercial antimicrobial susceptibility tests derived from BMD method are available. We investigated the performance of four different commercial tests: Sensititre™, SensiTest™ Colistin, Micronaut MIC Strip Colistin and UMIC Colistin using 70 clinical isolates (half of them was deemed by VITEK2 as resistant), including iso

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Hillemann, Doris, Emmanuelle Cambau, Silke Polsfuß, and Inna Friesen. "Comparison of a modified broth microdilution Sensititre™ SLOMYCOI assay with the CLSI-recommended agar disk elution method for antimicrobial susceptibility testing of Mycobacterium haemophilum." Journal of Antimicrobial Chemotherapy, May 26, 2025. https://doi.org/10.1093/jac/dkaf162.

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Abstract Objectives Mycobacterium haemophilum is a fastidious nontuberculous mycobacterium that causes severe infections in immunocompromised patients. Due to its complex growth requirements, its detection and antimicrobial susceptibility testing (AST) remain challenging. This study aimed to compare the performance of a modified commercial broth microdilution method (Sensititre™ Myco susceptibility plates with added haemin) with the standard Clinical and Laboratory Standards Institute (CLSI) agar disk elution method for AST of M. haemophilum. Methods We conducted 20 comparative AST tests on M.

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Kariyawasam, Ruwandi, Priyanka Challa, Rachel Lau, and Andrea K. Boggild. "Susceptibility testing of Leishmania spp. against amphotericin B and fluconazole using the Sensititre™ YeastOne™ YO9 platform." BMC Infectious Diseases 19, no. 1 (2019). http://dx.doi.org/10.1186/s12879-019-4237-3.

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Wareham, D., M. Attwood, A. L. Casey, et al. "P43 In vitro activity of cefiderocol and comparators against Gram-negative pathogens: ARTEMIS study in the UK." JAC-Antimicrobial Resistance 4, Supplement_1 (2022). http://dx.doi.org/10.1093/jacamr/dlac004.042.

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Abstract Objectives Cefiderocol (CFDC) is a novel siderophore cephalosporin approved in Europe for the treatment of infections caused by aerobic Gram-negative (GN) bacteria in adults with limited treatment options. The aim of the ARTEMIS study was to evaluate the in vitro activity of CFDC and comparators against recent clinical isolates collected across five countries in Europe. Here we report susceptibility data from isolates collected in the UK. Methods From January to December 2020, GN clinical isolates were collected from hospitalized patients from all infection sites (excluding the urinar

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Martens, Steven, Lize Cuypers, Florian Bélik, et al. "Multicenter comparison of Etest, Vitek2 and BD Phoenix to broth microdilution for beta-lactam susceptibility testing of Streptococcus pneumonia." European Journal of Clinical Microbiology & Infectious Diseases, May 27, 2024. http://dx.doi.org/10.1007/s10096-024-04847-2.

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Abstract Purpose To assess performance of Etest®, Vitek®2 and BD Phoenix™ to determine the susceptibility of Streptococcus pneumoniae strains to penicillin, ampicillin and cefotaxime. Methods Sixty unique S. pneumoniae challenge strains were selected to cover a wide range of penicillin, ampicillin and cefotaxime minimal inhibitory concentrations (MICs). Strains were analyzed in four different Belgian laboratories. Etest® benzylpenicillin (BEN), ampicillin/amoxicillin (AMP) and cefotaxime (CTA) (bioMérieux), Vitek®2 AST-ST03 (bioMérieux) and BD Phoenix™ SMIC/ID-11 testing were each performed in

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Ceballos-Garzon, Andres, Marion Holzapfel, Jeremy Welsch, and Derry Mercer. "Identification and antifungal susceptibility patterns of reference yeast strains to novel and conventional agents: a comparative study using CLSI, EUCAST and Sensititre YeastOne methods." JAC-Antimicrobial Resistance 7, no. 2 (2025). https://doi.org/10.1093/jacamr/dlaf040.

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Abstract Objectives The aim of this study was to identify and determine the MICs of 13 antifungal drugs, including the novel agents ibrexafungerp, manogepix and rezafungin, against 22 laboratory reference strains from 14 different Candida spp. and allied yeast genera using the EUCAST, CLSI and Sensititre™ YeastOne™ (SYO) methods. Results Complete agreement between molecular and proteomics methods was observed for identification. The compounds with the greatest in vitro activity, as indicated by the lowest geometric mean MIC (GM), were manogepix (GM: 0.01), isavuconazole (GM: 0.05) and rezafung

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Gourav, Sudesh, Himanshu Mishra, Immaculata Xess, et al. "Fusarium spp. Causing invasive disease in humans: a case series from north India." Medical Mycology, November 5, 2024. http://dx.doi.org/10.1093/mmy/myae111.

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Abstract Owing to their inherent resistance to different classes of antifungals, early identification of Fusarium spp. is crucial. In this study, ten clinical isolates were included from patients with invasive fusariosis involving lungs, sinuses or both. Clinico-radiological data were collected. Samples were processed by standard laboratory procedures. Three gene regions (ITS, TEF1 and RPB2) were amplified by PCR for multilocus sequencing. Fusarium MLST, FUSARIUM-ID and FUSARIOID-ID databases were used for final identification. Antifungal susceptibility testing was performed by broth microdilu

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Vittoria, Mattioni Marchetti, Kuka Angela, Piazza Aurora, et al. "Enterobacter asburiae ST229: an emerging carbapenemases producer." Scientific Reports 14, no. 1 (2024). http://dx.doi.org/10.1038/s41598-024-55884-y.

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AbstractEnterobacter asburiae, member of the Enterobacter cloacae complex (ECC) group, shows an increasing clinical relevance being responsible for infections like pneumonia, urinary tract infections and septicemia. The aim of the present study was the investigation of the genomic features of two XDR E. asburiae ST229 clinical strains co-carrying blaNDM-1 and blaVIM-1 determinants, collected in October 2021 and in June 2022, respectively. Two E. asburiae strains were collected from rectal swabs of as many patients admitted to the cardiopulmonary intensive care unit of Fondazione I.R.C.C.S. “Po

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Ngo, Thi Minh Chau, Dong Duong Ton That, Phuong Anh Ton Nu, et al. "A notable azole-nonsusceptible Candida orthopsilosis in the Candida parapsilosis complex isolated from onychomycosis in Hue City, Central Vietnam." Medical Mycology, July 21, 2025. https://doi.org/10.1093/mmy/myaf064.

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Abstract The Candida parapsilosis complex, consisting of C. parapsilosis sensu stricto, C. orthopsilosis, and C. metapsilosis, is a major cause of Candida onychomycosis. Increasing reports of high levels of resistance to antifungal drugs, particularly fluconazole and echinocandin, have raised concerns about C. parapsilosis complex. This study investigates antifungal resistance and hydrolytic enzyme activity in these species. Species were identified using PCR-RFLP and ITS1-4 sequencing. Antifungal susceptibility was assessed using Sensititre™ YeastOne™. Hydrolytic enzyme production was assessed

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Chen, Xin-Fei, Han Zhang, Xin-Miao Jia, et al. "Antifungal susceptibility profiles and drug resistance mechanisms of clinical Candida duobushaemulonii isolates from China." Frontiers in Microbiology 13 (December 5, 2022). http://dx.doi.org/10.3389/fmicb.2022.1001845.

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Candida duobushaemulonii, type II Candida haemulonii complex, is closely related to Candida auris and capable of causing invasive and non-invasive infections in humans. Eleven strains of C. duobushaemulonii were collected from China Hospital Invasive Fungal Surveillance Net (CHIF-NET) and identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF), VITEK 2 Yeast Identification Card (YST), and internal transcribed spacer (ITS) sequencing. Whole genome sequencing of C. duobushaemulonii was done to determine their genotypes. Furthermore, C. duobushaem

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Ajapuje, Preeti. "P027 Early warning bells: emergence of fluconazole resistance in Candida parapsilosis." Medical Mycology 60, Supplement_1 (2022). http://dx.doi.org/10.1093/mmy/myac072.p027.

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Abstract Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Preeti S. Ajapuje¹, Parikshit S. Prayag¹, Bharat D. Purandare¹, Sampada A. Patwardhan², Shweta P. Panchakshari¹, Rajeev N. Soman¹ Department of Infectious Diseases, Deenanath Mangeshkar Hospital, Pune 2Department of Microbiology, Deenanath Mangeshkar Hospital, Pune Objectives To study the susceptibility patterns in blood isolates of Candida parapsilosis at a tertiary care center. Methods This was a retrospective observational study of nine cases of candidemia due to C. Parapsilosis over a period of 1 year. Data were collected us

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Aupaix, Antoine, Kamila Lamraoui, Hector Rodriguez-Villalobos, Ahalieyah Anantharajah, and Alexia Verroken. "Comparison of two commercial broth microdilution panels for multidrug-resistant Gram-negative bacteria: Thermo Scientific™ Sensititre DKMGN vs. Beckman Coulter MicroScan NMDRM1." Frontiers in Microbiology 15 (October 16, 2024). http://dx.doi.org/10.3389/fmicb.2024.1480687.

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IntroductionAntimicrobial susceptibility testing (AST) using broth microdilution (BMD) is usually the reference method to obtain accurate minimum inhibitory concentrations and optimally manage infections with resistant organisms. Several commercial dry BMD are available for AST in clinical laboratories.Materials and methodsTwo commercial BMD panels for testing of multidrug-resistant Gram-negative bacteria were compared: the Thermo Scientific™ Sensititre DKMGN and the Beckman Coulter NMDRM1, for 17 antimicrobial agents.ResultsA total of 207 isolates were tested: three ATCC strains and one NCTC

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Zhao, Jin, Xinli Shen, Lulu Jin, Songjun Ji, and Xinling Pan. "Resistance phenotypes and genomic features of Mycobacterium seoulense isolates." Frontiers in Cellular and Infection Microbiology 15 (April 7, 2025). https://doi.org/10.3389/fcimb.2025.1553591.

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BackgroundMycobacterium seoulense (M. seoulense) is an emerging pathogen increasingly associated with infections; however, its resistance phenotypes and genomic characteristics remain largely unknown.MethodsSeven M. seoulense isolates were collected from clinical samples. Drug susceptibility testing was conducted using Sensititre™ SLOMYCO2 susceptibility plates. Whole genome sequencing and supporting bioinformatics analyses were performed to analyze the genomic features.ResultsAll M. seoulense isolates (n=7) exhibited growth on 7H10 agar medium containing thiophenecarboxylic acid hydrazide or

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Chen, Xin-Fei, Wei Zhang, Xin Fan, et al. "Antifungal Susceptibility Profiles and Resistance Mechanisms of Clinical Diutina catenulata Isolates With High MIC Values." Frontiers in Cellular and Infection Microbiology 11 (October 29, 2021). http://dx.doi.org/10.3389/fcimb.2021.739496.

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Diutina catenulata (Candida catenulata) is an ascomycete yeast species widely used in environmental and industrial research and capable of causing infections in humans and animals. At present, there are only a few studies on D. catenulata, and further research is required for its more in-depth characterization and analysis. Eleven strains of D. catenulata collected from China Hospital Invasive Fungal Surveillance Net (CHIF-NET) and the CHIF-NET North China Program were identified using matrix-assisted laser desorption ionization–time of flight mass spectrometry and internal transcribed spacer

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Mbelele, Peter M., Christian Utpatel, Elingarami Sauli, et al. "Whole genome sequencing-based drug resistance predictions of multidrug-resistant Mycobacterium tuberculosis isolates from Tanzania." JAC-Antimicrobial Resistance 4, no. 2 (2022). http://dx.doi.org/10.1093/jacamr/dlac042.

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Abstract Background Rifampicin- or multidrug-resistant (RR/MDR) Mycobacterium tuberculosis complex (MTBC) strains account for considerable morbidity and mortality globally. WGS-based prediction of drug resistance may guide clinical decisions, especially for the design of RR/MDR-TB therapies. Methods We compared WGS-based drug resistance-predictive mutations for 42 MTBC isolates from MDR-TB patients in Tanzania with the MICs of 14 antibiotics measured in the Sensititre™ MycoTB assay. An isolate was phenotypically categorized as resistant if it had an MIC above the epidemiological-cut-off (ECOFF

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Sharma, Meenu Kaushal, Yanni La, Debra Janella, and Hafid Soualhine. "A real-time PCR assay for rapid identification of inducible and acquired clarithromycin resistance in Mycobacterium abscessus." BMC Infectious Diseases 20, no. 1 (2020). http://dx.doi.org/10.1186/s12879-020-05686-0.

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Abstract Background Mycobacterium abscessus is a rapidly growing mycobacteria involved in severe infections of the lung, skin, or soft tissue. Macrolides such as clarithromycin are the recommended first line drugs for treatment of M. abscessus infections. However, M. abscessus has dual mechanisms of resistance to macrolides, making treatment by macrolides difficult. A functional erm(41) gene confers for inducible resistance while acquired mutations on the 23S rRNA rrl gene confer for constitutive resistance. Methods We have developed a real-time PCR assay to detect both inducible and acquired

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Halliday, Catriona L., Enoch Tay, Wendy Green, et al. "In vitro activity of olorofim against 507 filamentous fungi including antifungal drug-resistant strains at a tertiary laboratory in Australia: 2020–2023." Journal of Antimicrobial Chemotherapy, August 6, 2024. http://dx.doi.org/10.1093/jac/dkae267.

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Abstract Background New antifungal agents are required to mitigate against azole-resistant Aspergillus and drug-resistant non-Aspergillus moulds. The novel orotomide, olorofim (F2G, Manchester, UK), has potent fungicidal activity against Aspergillus including azole-resistant Aspergillus fumigatus, Lomentospora prolificans and Scedosporium spp. Development of olorofim-specific clinical breakpoints/epidemiological cut-off values requires reliable MIC data. Objectives Determine the in vitro activity of olorofim compared with standard antifungals against mould pathogens at an Australian hospital.

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Sebbag, Lionel, Victoria L. Broadbent, Danielle E. Kenne, Ashtyn L. Perrin, and Jonathan P. Mochel. "Albumin in Tears Modulates Bacterial Susceptibility to Topical Antibiotics in Ophthalmology." Frontiers in Medicine 8 (November 30, 2021). http://dx.doi.org/10.3389/fmed.2021.663212.

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Bacterial keratitis is a serious and vision-threatening condition in veterinary and human patients, one that often requires culture and susceptibility testing to adjust therapy and improve clinical outcomes. The present study challenges the antimicrobial susceptibility testing (AST) paradigm in ophthalmology, enabling more accurate in vitro-to-in vivo translation by incorporating factors normally present during host-pathogen interactions in clinical patients. Thirty bacteria (10 Staphylococcus pseudintermedius, 10 Streptococcus canis, 10 Pseudomonas aeruginosa) were isolated from canine patien

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Chiaverini, A., R. Curi, M. Gori, et al. "Antimicrobial resistance of Listeria monocytogenes human strains and correlation to genomic data." European Journal of Public Health 31, Supplement_3 (2021). http://dx.doi.org/10.1093/eurpub/ckab165.292.

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Abstract Background Studies checking antimicrobial resistance (AMR) of Listeria monocytogenes (Lm) are ongoing, coupled with disease surveillance. Lm resistant strains are reported and are increasing. The aim of the work was to investigate AMR of clinical strains of Lm collected from nine regions (mostly in Lombardy and Marche regions) from 2008 to 2020. Methods The dataset consisted of 233 Lm human strains collected from nine regions during the period 2008-2020. All the strains were tested using Sensititre™ Haemophilus Plate (Thermo Scientific, Milano, Italy). Results were expressed according

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Kubai, Melissa A., Mackenzie M. Roy, Chloe C. Stinman, Danielle E. Kenne, Rachel A. Allbaugh, and Lionel Sebbag. "Topical blood products modulate the effects of ophthalmic antibiotics against common bacterial pathogens in dogs with infectious keratitis." Frontiers in Veterinary Science 11 (July 12, 2024). http://dx.doi.org/10.3389/fvets.2024.1417842.

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Bacterial keratitis is a common and serious condition that often leads to vision impairment and potential loss of the eye if not treated promptly and adequately. Topical blood products are often used concurrently with topical antibiotics, helping to mitigate corneal ‘melt’ from proteases released on the ocular surface. However, blood products are rich in albumin and could affect the efficacy of antibiotics due to drug-protein binding. In this study, serum and plasma samples were harvested from 10 healthy dogs and 10 healthy horses, obtaining fresh and frozen (1 month at −20°C) aliquots for in

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Doyle, Aoife, Máire McElroy, and Thomas Rogers. "P24 Antimicrobial susceptibility profiles of hypervirulent strains of Clostridioides difficile of pig and human origin." JAC-Antimicrobial Resistance 6, Supplement_2 (2024). http://dx.doi.org/10.1093/jacamr/dlae136.028.

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Abstract Background Clostridioides difficile places an increasing burden on healthcare because of emerging hypervirulent strains such as RT078/ST11 that may be resistant to commonly prescribed antibiotics e.g. fluoroquinolones. Pigs are often colonized by RT078/ST11 and act as potential reservoir for human C. difficile infection (CDI). They are the highest consumers of veterinary antimicrobials in many countries.1 We investigated the susceptibility of C. difficile to antibiotics that are commonly prescribed and/or used to treat CDI. Methods Sequenced C. difficile (humans=50, pigs=40), collecte

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Chen, Junzhu, Niya Hu, Hongzhi Xu, et al. "Molecular Epidemiology, Antifungal Susceptibility, and Virulence Evaluation of Candida Isolates Causing Invasive Infection in a Tertiary Care Teaching Hospital." Frontiers in Cellular and Infection Microbiology 11 (September 15, 2021). http://dx.doi.org/10.3389/fcimb.2021.721439.

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BackgroundThe incidence of invasive candidiasis is increasing worldwide. However, the epidemiology, antifungal susceptibility, and virulence of Candida spp. in most hospitals remain unclear. This study aimed to evaluate invasive candidiasis in a tertiary care hospital in Nanchang City, China.MethodsMALDI-TOF MS and 18S rDNA ITS sequencing were used to identify Candida strains. Randomly amplified polymorphic DNA analysis was used for molecular typing; biofilm production, caseinase, and hemolysin activities were used to evaluate virulence. The Sensititre™ YeastOne YO10 panel was used to examine

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Donohue, Lindsay E., Heather L. Cox, Jenni Thomas, Tiffany S. Kidd, Hiba N. Mohammed, and Amy Mathers. "137. Penicillin (PCN) Gradient Diffusion Overcalls Resistance and Promotes Unnecessary Vancomycin (VAN) Use in Enterococcus faecalis Bloodstream Infections (BSI)." Open Forum Infectious Diseases 10, Supplement_2 (2023). http://dx.doi.org/10.1093/ofid/ofad500.210.

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Abstract Background Reports of a PCN-resistant (R), ampicillin-susceptible (S) Enterococcus faecalis (PRASEF) phenotype associated with elevated piperacillin and imipenem minimum inhibitory concentrations (MICs) may drive hesitation to use these agents when a PCN MIC is unknown and/or result in the addition of a glycopeptide. However, PCN MICs by broth microdilution are not readily available in many clinical laboratories and some commercial methods may overcall PRASEF. We sought to assess the rate of overcalling PCN MICs by gradient diffusion compared to broth microdilution and the impact of P

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