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1

Wong, Raphael C. Lateral flow immunoassay. Springer, 2009.

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2

C, Wong Raphael, and Tse Harley Y, eds. Lateral flow immunoassay. Springer, 2009.

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3

Faughnan, Marie E. Sensitivity and specificity of screening for pulmonary arteriovenous malformations. National Library of Canada, 2000.

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4

Tatsas, Armanda. Atlas of radiologic-cytopathologic correlations. Demos Medical Pub., 2012.

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5

Tatsas, Armanda. Atlas of radiologic-cytopathologic correlations. Demos Medical Pub., 2012.

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6

Bianchi, Matt T. Diagnostic test interpretation and reasoning under uncertainty. Nova Science Publishers, 2010.

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7

K, Pfeffer, ed. Function and specificity of [alpha/delta] T cells: International Workshop, Schloss Elmau, Bavaria, FRG, October 14-16, 1990. Springer, 1991.

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8

Franzen, Michael D. Reliability and validity in neuropsychological assessment. 2nd ed. Kluwer Academic/Plenum Publishers, 2000.

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9

Special Programme for Research and Training in Tropical Diseases, Foundation for Innovative New Diagnostics, and Centers for Disease Control and Prevention (U.S.), eds. Malaria rapid diagnostic test performance: Results of WHO product testing of malaria RDTs : round 2 (2009). World Health Organization on behalf of the Special Programme for Research and Training in Tropical Diseases, 2010.

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10

Kesoretskikh, Ivan, and Sergey Zotov. Landscape vulnerability: concept and assessment. INFRA-M Academic Publishing LLC., 2019. http://dx.doi.org/10.12737/1045820.

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The monograph presents a methodology for assessing the vulnerability of landscapes to external influences. A comparative analysis of the concepts of "stability", "sensitivity", "vulnerability" in relation to natural complexes. An overview of existing methods for assessing the vulnerability of natural complexes is presented. The author's method of assessing the vulnerability of landscapes to anthropogenic impacts is described. The methodology is based on: selection and justification of criteria for assessing the vulnerability of landscapes; preparation of a parametric matrix and gradation of as
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11

World Health Organization (WHO). Malaria rapid diagnostic test performance: Results of WHO product testing of malaria RDTs : round 1 (2008). World Health Organization on behalf of the Special Programme for Research and Training in Tropical Diseases, 2009.

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12

Assessment of Clinical Sensitivity & Specificity of Laboratory Tests. NCCLC, 1987.

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13

Noise, Noise Sensitivity and Psychiatric Disorder: Epidemiological and Psychophysiological Studies (Psychological Medicine Supplements). Cambridge University Press, 1993.

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14

Sensitivity Analysis. Wiley, 2000.

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15

Scott, E. M., A. Saltelli, and K. Chan. Sensitivity Analysis. Wiley & Sons, Limited, John, 2008.

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16

Sensitivity and specificity of common scintigraphic procedures: A review of clinical efficacy. Year Book Medical Publishers, 1985.

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17

Tator, Lisa M. A comparative study of ABAcard HemaTrace and RSID-Blood℗ʼ with emphasis on sensitivity and specificity. 2009.

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18

Ali, Syed Z., and Armanda Tatsas. Atlas of Radiologic-Cytopathologic Correlations. Springer Publishing Company, Incorporated, 2012.

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19

Pfeffer, Klaus. Function And Specificity Of Gama/delta T Cells (Current Topics in Microbiology & Immunology). Edited by Klaus Pfeffer. Springer, 1991.

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20

Peacock, Janet L., and Sally M. Kerry. Single group studies. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780198599661.003.0006.

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21

Elwood, Mark. Error and bias in observations. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199682898.003.0006.

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This chapter distinguishes error and bias, non-differential and differential misclassification distinguished. Non-differential misclassification almost always biases results toward the null, while differential misclassification can affect results in any direction. Methods to minimise observation bias include single, double and triple blind assessment. It discusses recall and other biases, with methods of assessment and avoidance, and practical issues on reducing error and bias. In part two, it shows how to measure and adjust for observational error and bias, including Kappa and adjusting for n
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22

Peacock, Janet L., Sally M. Kerry, and Raymond R. Balise. Single group studies. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198779100.003.0006.

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Chapter 6 discusses single group studies, and covers prevalence, how to present results, screening studies, calculating, and presenting sensitivity and specificity. It discusses how to deal with calculations with a rare condition where the numbers are small. Finally, it discusses the use of receiver operating characteristic (ROC) curves. The chapter includes analyses using Stata, SAS, SPSS, and R.
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23

Prout, Jeremy, Tanya Jones, and Daniel Martin. Physics and clinical measurement. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199609956.003.0010.

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This chapter includes general concepts of interpreting laboratory results such as specificity, sensitivity and predictive values. In the measurement of blood coagulation, the cell-based mechanism for blood clotting is explained and the role of point-of-care viscoelastic testing using thromboelastography is described. Effects of ionizing radiation, safe levels, and radiation protection are also included.
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24

Harrison, Mark. 2 × 2 Contingency table. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198765875.003.0064.

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This chapter describes the 2 × 2 contingency table as it applies to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter outlines the key details of sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratios for positive and negative results, and the 2 × 2 contingency table. This chapter is laid out exactly following the RCEM syllabus, to allow easy reference and consolidation of learning.
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25

Rolak, Loren A. Diagnosis of Multiple Sclerosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199341016.003.0006.

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Because no laboratory test or imaging study is both highly sensitive and highly specific for multiple sclerosis, some uncertainty often accompanies the diagnosis. Various guidelines have been developed to assist the clinician, including the much-modified and commonly used McDonald criteria. Typical features of the history, the physical examination, and magnetic resonance imaging findings usually allow for a secure diagnosis. However, limitations inherent in any testing modality still pose challenges. This is especially true for diagnosis of primary progressive multiple sclerosis because the se
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26

Missing Data in Longitudinal Studies: Strategies for Bayesian Modeling and Sensitivity Analysis (Monographs on Statistics and Applied Probability). Chapman & Hall/CRC, 2008.

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27

Laureno, Robert. Diagnosis. Edited by Robert Laureno. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190607166.003.0003.

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This chapter on “Diagnosis” examines topics in neurologic diagnosis such as sensitivity and specificity. Special topics are addressed including reasons for ordering diagnostic tests, multidimensional diagnosis, simultaneous presence of multiple diagnoses, diagnostic pitfalls, and formal diagnostic criteria. All diagnostic tests have limitations. This chapter discusses those limitations and the ways that a practitioner can overcome them. The importance of clear communication between doctor and patient and a healthy dose of suspicion and skepticism in interpreting patient presenting symptoms and
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28

Wolter, Tilman. Cervical Transforaminal/Nerve Root Injections: Computed Tomography. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199908004.003.0006.

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Computed tomography (CT)–guided selective cervical nerve root blocks, particularly in the dorsal/posterior access, are sensitive, specific, efficacious, and safe. If performed with a lateral/anterolateral access, the CT-fluoroscopic technique with real-time visualization should be chosen. In comparison to fluoroscopy-guided nerve root blocks, CT guidance offers a more precise visualization of the contrast agent. While the advantages of CT guidance seem to outweigh the slightly higher exposure to radiation, this specific topic is debatable and requires additional scientific inquiry. Comparative
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29

D’Orsi, Carl. Breast Imaging Reporting and Data System (BI-RADS). Edited by Christoph I. Lee, Constance D. Lehman, and Lawrence W. Bassett. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190270261.003.0005.

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This chapter, devoted to the Breast Imaging Reporting and Data System (BI-RADS), describes the standardized language applied to findings in mammography, breast ultrasound, and breast MRI. BI-RADS terms most frequently used are described, and most are illustrated by figures. In addition, the rules for a facility and radiologist audit are described, with definitions of true positive (TP), false positive (FP), true negative (TN), and false negative (FN) findings. Sensitivity (Se), specificity (Sp), positive predictive values 1, 2, and 3 (PPV1, 2, 3), and cancer detection rate are defined. An exam
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30

Basu, Sanjay. Fundamentals. Edited by Sanjay Basu. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190667924.003.0001.

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In this chapter, the author defines and provides examples of several key terms used in public health and healthcare modeling research. The chapter begins by clarifying the differences between key terms used to describe rates of disease (incidence, prevalence, and mortality) as well as the performance characteristics of tests used to detect disease (sensitivity, specificity, positive predictive value, and negative predictive value), prevent or treat disease (odds ratios, relative risks), understand studies (case-control, cohort, and randomized controlled trials), and avoid common study problems
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31

Lee, Christoph I. Efficacy of Screening Breast MRI for High-Risk Women. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190223700.003.0039.

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This chapter, found in the cancer screening and management section of the book, provides a succinct synopsis of a key study examining the efficacy of screening breast magnetic resonance imaging (MRI) for high-risk women. This summary outlines the study methodology and design, major results, limitations and criticisms, related studies and additional information, and clinical implications. Breast MRI screening has higher sensitivity than mammography for high-risk women, but both the specificity and positive predictive value are lower than for mammography screening. In addition to outlining the m
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32

Katirji, Bashar. Case 23. Edited by Bashar Katirji. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190603434.003.0027.

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Guillain-Barré syndrome is the prototype of acute immune-mediated neuropathies. Guillain-Barré syndrome has several subtypes including acute inflammatory demyelinating polyneuropathy, acute motor axonal neuropathy, and acute motor sensory axonal neuropathy. Guillain-Barré syndrome has also several variants including Miller Fisher syndrome, ataxic form, and pharyngeal–cervical–brachial form. This case highlights the clinical findings in Guillain-Barré syndrome and discusses in details the diagnostic criteria that are essential in confirming the diagnosis and excluding mimickers of the disorder.
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33

Warner, Matthew A., Carlos Marquez de la Plata, David S. Liebeskind, and Ramon Diaz-Arrastia. Imaging Assessment of Brain Injury. Edited by David L. Reich, Stephan Mayer, and Suzan Uysal. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190280253.003.0003.

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Imaging plays a pivotal role in discerning the extent and nature of brain injuries. Advances in neuroimaging techniques have improved sensitivity for detecting smaller lesions, improved the anatomical specificity of lesions in white matter, and improved the prognostic value of detected lesions. Novel quantitative methods allow measurements of hemorrhage and infarct volume in the acute phase of injury, and regional brain atrophy and functional disconnectedness months after injury. It is likely that the success of future clinical trials of neuroprotective therapies will be dependent on reliable
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34

Mathiesen, Amber, and Kali Roy. Prenatal Screening. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190681098.003.0003.

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This chapter provides information about a genetic counselor’s role in prenatal screening, including discussing and offering options to a patient, interpreting and providing results, or managing referrals based on abnormal results. It discusses how a screen is evaluated using sensitivity, specificity, positive predictive value, negative predictive value, and personal utility. It provides a detailed description of both maternal serum screening and cell-free DNA testing. The maternal serum screening discussion includes information on multiples of median, calculating risk, timing, pattern associat
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35

Pitt, Matthew. Results of the clinical application of SPACE in suspected disorders of the neuromuscular junction. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198754596.003.0011.

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Findings in a large cohort of children with disorders of the neuromuscular junction are presented along with those in non-primary neuromuscular junction abnormalities. From these results it is possible to derive test parameters for stimulated potential analysis using concentric needle electrodes (SPACE) including sensitivity and specificity, along with positive and negative predictive values. The differences between performing stimulation techniques to determine jitter in children and adults are highlighted as are technical aspects and the effects of the differential diagnosis on interpretatio
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36

Evaluating medical tests: Objective and quantitative guidelines. Sage Publications, 1992.

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37

Kraemer, Helena Chmura. Evaluating Medical Tests: Objective and Quantitative Guidelines. SAGE Publications, Incorporated, 2012.

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38

Siebert, Stefan, Sengupta Raj, and Alexander Tsoukas. Inflammatory back pain. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198755296.003.0006.

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Inflammatory back pain (IBP) refers to a collection of symptoms that may help identify patients with possible inflammatory spinal disease. A number of criteria sets have been proposed for IBP, which share common features such as: onset of symptoms aged <40 years, alternating buttock pain, improvement with exercise, worsening with rest, gradual onset, early morning stiffness, and improvement with NSAIDs. The IBP criteria were initially developed and validated in patients with ankylosing spondylitis, but have subsequently been shown to perform similarly in patients with axial spondyloarthriti
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39

Giannitsis, Evangelos, and Hugo A. Katus. Biomarkers in acute coronary syndromes. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0036.

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Biomarker testing in the evaluation of a patient with acute chest pain is best established for cardiac troponins that allow the diagnosis of myocardial infarction, risk estimation of short- and long-term risk of death and myocardial infarction, and guidance of pharmacological therapy, as well as the need and timing of invasive strategy. Newer, more sensitive troponin assays have become commercially available and have the capability to detect myocardial infarction earlier and more sensitively than standard assays, but they are hampered by a lack of clinical specificity, i.e. the ability to disc
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40

Giannitsis, Evangelos, and Hugo A. Katus. Biomarkers in acute coronary syndromes. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199687039.003.0036_update_001.

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Biomarker testing in the evaluation of a patient with acute chest pain is best established for cardiac troponins that allow the diagnosis of myocardial infarction, risk estimation of short- and long-term risk of death and myocardial infarction, and guidance of pharmacological therapy, as well as the need and timing of invasive strategy. Newer, more sensitive troponin assays have become commercially available and have the capability to detect myocardial infarction earlier and more sensitively than standard assays, but they are hampered by a lack of clinical specificity, i.e. the ability to disc
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41

Giannitsis, Evangelos, and Hugo A. Katus. Biomarkers in acute coronary syndromes. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199687039.003.0036_update_002.

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Biomarker testing in the evaluation of a patient with acute chest pain is best established for cardiac troponins that allow the diagnosis of myocardial infarction, risk estimation of short- and long-term risk of death and myocardial infarction, and guidance of pharmacological therapy, as well as the need and timing of invasive strategy. Newer, more sensitive troponin assays have become commercially available and have the capability to detect myocardial infarction earlier and more sensitively than standard assays, but they are hampered by a lack of clinical specificity, i.e. the ability to disc
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42

Paul, Richard, and Susanna Price. Imaging the cardiovascular system in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0143.

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Cardiac imaging in the critically ill can be challenging. Interpretation requires a broad knowledge of cardiovascular pathophysiology, the range of available investigations, and their sensitivity and specificity in diagnosing individual conditions. Applying first principles and interpreting findings in the clinical context are mandatory. Useful non-invasive investigations include simple chest X-ray, thoracic ultrasound, and computed tomography (CT) to detect pulmonary and extrapulmonary pathology, whilst CT coronary angiography can evaluate stent and graft patency, and identify extramural plaq
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43

Meijer, Richard P., Alexandre R. Zlotta, and Bas W. G. van Rhijn. Bladder cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0077.

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High-grade non-muscle-invasive bladder cancer (HG-NMIBC) represents the most aggressive spectrum of this non-invasive cancer. This collective term includes all high-grade NMI urothelial carcinoma (UC), such as those without invasion (pTa), those with lamina propria invasion (pT1), and those that are only/have concomitant carcinoma in situ (CIS; pTis). These cancers have a high risk for intravesical recurrence (around 46–78% at five years) and progression (between 6–45% at five years) to muscle-invasive bladder cancer (MIBC). As with all UC, their presentation can be with visible haematuria or
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44

Gattringer, Thomas, Christian Enzinger, Stefan Ropele, and Franz Fazekas. Brain imaging (CT/MRI). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198722366.003.0007.

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In the acute phase of a suspected stroke, timely brain imaging with rapid and qualified interpretation is a crucial diagnostic step to inform patient management. While brain computed tomography is usually sufficient to indicate thrombolysis within the approved time window (by rapidly excluding intracranial haemorrhage), it often fails to show the actual site and extent of infarction as well as other pathologies, which may mimic a stroke. Magnetic resonance imaging (MRI) has a much higher sensitivity and specificity for ischaemic vascular brain changes and thus allows direct demonstration of th
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45

Ray, Sumantra (Shumone), Sue Fitzpatrick, Rajna Golubic, Susan Fisher, and Sarah Gibbings, eds. Navigating research methods: basic concepts in biostatistics and epidemiology. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199608478.003.0002.

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This chapter provides an overview of the basic concepts in biostatistics and epidemiology. Section 1: Basic concepts in biostatistics The concepts in biostatistics include: 1. descriptive statistical methods (which comprise of frequency distribution, distribution shapes, and measures of central tendency and dispersion); and 2. inferential statistics which is applied to make inferences about a population from the sample data. Non-probability and probability sampling methods are outlined. This section provides simple explanation of the complex concepts of significance tests and confidence interv
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46

Buechel, Ronny R., and Aju P. Pazhenkottil. Basic principles and technological state of the art: hybrid imaging. Edited by Philipp Kaufmann. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0121.

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The core principle of hybrid imaging is based on the fact that it provides information beyond that achievable with either data set alone. This is attained through the combination and fusion of two datasets by which both modalities synergistically contribute to image information. Hybrid imaging is, thus, more powerful than the sum of its parts, yielding improved sensitivity and specificity. While datasets for integration may be obtained by a variety of imaging modalities, its merits are intuitively best exploited when combining anatomical and functional imaging, particularly in the setting of e
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47

Alexander, Peter D. G., and Malachy O. Columb. Presentation and handling of data, descriptive and inferential statistics. Edited by Jonathan G. Hardman. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0028.

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The need for any doctor to comprehend, assimilate, analyse, and form an opinion on data cannot be overestimated. This chapter examines the presentation and handling of such data and its subsequent statistical analysis. It covers the organization and description of data, measures of central tendency such as mean, median, and mode, measures of dispersion (standard deviation), and the problems of missing data. Theoretical distributions, such as the Gaussian distribution, are examined and the possibility of data transformation discussed. Inferential statistics are used as a means of comparing grou
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48

Tvorogova, M. G. Laboratory diagnosis of infectious diseases. Edited by V. G. Akimkin. Central Research Institute for Epidemiology, 2020. http://dx.doi.org/10.36233/978-5-9900432-0-6.

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The book contains a detailed description of various laboratory tests used for the etiological diagnosis of diseases caused by viruses, bacteria, fungi, protozoa. The advantages and disadvantages of direct and indirect methods for determining more than 50 pathogens are noted, their diagnostic sensitivity and specificity are compared. Information about the choice of the optimal type of specimens and the time of its collection for testing will undoubtedly help the clinician to choose an effective algorithm for laboratory diagnosis of a certain infection and will avoid unnecessary expenditures of
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49

Hayashi, Daichi, Ali Guermazi, and Frank W. Roemer. Radiography and computed tomography imaging of osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0016.

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Osteoarthritis (OA) is the most prevalent joint disorder in the elderly worldwide and there is still no effective treatment, other than joint arthroplasty for end-stage OA, despite ongoing research efforts. Imaging is essential for assessing structural joint damage and disease progression. Radiography is the most widely used first-line imaging modality for structural OA evaluation. Its inherent limitations should be noted including lack of ability to directly visualize most OA-related pathological features in and around the joint, lack of sensitivity to longitudinal change and missing specific
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50

Advanced Bayesian methods for medical test accuracy. Taylor & Francis, 2012.

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