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Onwubu, Stanley Chibuzor, Phumlane Selby Mdluli, Shenuka Singh, Sanele Nyembe, and Rookmoney Thakur. "Evaluating the Abrasivity of a Nanosized Eggshell–Titanium Dioxide on Tooth Enamel Using Atomic Force Microscopy." European Journal of Dentistry 14, no. 04 (2020): 598–604. http://dx.doi.org/10.1055/s-0040-1714172.
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Abstract Objectives This study aimed to evaluate nanosized eggshell–titanium dioxide (EB@TiO2) abrasiveness in comparison with calcium carbonate and hydrated silica-containing toothpaste. Material and Methods Thirty-five bovine tooth enamels were prepared, and specimens randomly assigned to a sample group of five (n = 7), namely, Colgate regular, Colgate pro-relief, Sensodyne rapid relief, Sensodyne repair, and EB@TiO2. Half of the enamel surface was brushed with each respective sample group, while the other half was covered with a tap. Statistical Analysis The mean roughness value (Ra) of the brushed and covered halves were measured using an atomic force microscope (AFM). To assess the surface morphology and changes, a scanning electron microscope (SEM) was performed. Using pair sample test and ANOVA, the Ra for the entire specimens were analyzed. A Bonferroni correction was used to identify the mean differences among the five groups (α=.05). Results The findings from this analysis show that all the tested toothpaste abraded the enamel significantly (p < 0.05). The abrasive value contained in toothpaste comprising calcium carbonate was lower than the silica toothpaste hydrated. Conclusion Overall, Colgate regular had the lowest toothpaste abrasivity, followed by EB@TiO2, while Sensodyne rapid relief had the most enamel wear. The prominent feature of this study suggests that EB@TiO2 is suitable for oral use, as its abrasivity is comparable with calcium carbonate-containing toothpaste.
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Carmen, Liliana Defta, Cristian Mănguță Ionuț, Albu Cristina-Crenguța, Albu Ştefan-Dimitrie, and Botoacă Oana. "Parallelism between the efficiency of Sensodyne toothpaste and Lacalut toothpaste with hydroxyapatite in oral hygiene." World Journal of Advanced Research and Reviews 16, no. 3 (2022): 098–106. https://doi.org/10.5281/zenodo.7894227.
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Currently, the concept of oro-dental prophylaxis and prevention is becoming more and more publicized among the population. These notions promote both the prevention of the development of dento-periodontal and oral structures diseases, diagnosing the diseases of the oral cavity and stopping their evolution, as well as the prevention of complications in the oro-maxillo-facial sphere. The purpose of this paper was to perform a comparative experimental study between the commensal oral flora and the composition of the biofilm after tooth brushing with Sensodyne Rapid Relief toothpaste and Lacalut toothpaste with hydroxyapatite. The study group included a number of 15 patients, of which 9 men and 6 women, aged between 20 and 71 years. The collection of biological preparations took place in the dental office, where the patients presented themselves for an individualized treatment plan, and the analysis and interpretation of the results were carried out in the Microbiology Discipline, “Carol Davila” University of Medicine and Pharmcy, Bucharest, Romania. According to the results of our study, following dental brushing with Lacalut toothpaste with hydroxyapatite, its effectiveness was demonstrated on species such as G+ lanceolate cocci, curved G+ bacilli, G- spindle bacilli or G- filamentous formations, while the effect antibacterial for G+ shells in diplo and short chains was not as expected. Sensodyne Rapid Relief Toothpaste has been shown to have a positive effect on species of G+ lanceolate cocci, G- fusiform bacilli, round-headed G+ bacilli, curved G+ bacilli or G- filamentous formations. On the other hand, on G+ cocci in diplo and short chains and epithelial cells it did not show the desired efficiency, these being found in the highest percentage. This study once again shows the importance of microscopic examination in assessing the effect of some toothpastes on the weight of the oral flora.
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Carmen Liliana Defta, Ionuț Cristian Mănguță, Cristina-Crenguța Albu, Ştefan-Dimitrie Albu, and Oana Botoacă. "Parallelism between the efficiency of Sensodyne toothpaste and Lacalut toothpaste with hydroxyapatite in oral hygiene." World Journal of Advanced Research and Reviews 16, no. 3 (2022): 098–106. http://dx.doi.org/10.30574/wjarr.2022.16.3.1306.
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Currently, the concept of oro-dental prophylaxis and prevention is becoming more and more publicized among the population. These notions promote both the prevention of the development of dento-periodontal and oral structures diseases, diagnosing the diseases of the oral cavity and stopping their evolution, as well as the prevention of complications in the oro-maxillo-facial sphere. The purpose of this paper was to perform a comparative experimental study between the commensal oral flora and the composition of the biofilm after tooth brushing with Sensodyne Rapid Relief toothpaste and Lacalut toothpaste with hydroxyapatite. The study group included a number of 15 patients, of which 9 men and 6 women, aged between 20 and 71 years. The collection of biological preparations took place in the dental office, where the patients presented themselves for an individualized treatment plan, and the analysis and interpretation of the results were carried out in the Microbiology Discipline, “Carol Davila” University of Medicine and Pharmcy, Bucharest, Romania. According to the results of our study, following dental brushing with Lacalut toothpaste with hydroxyapatite, its effectiveness was demonstrated on species such as G+ lanceolate cocci, curved G+ bacilli, G- spindle bacilli or G- filamentous formations, while the effect antibacterial for G+ shells in diplo and short chains was not as expected. Sensodyne Rapid Relief Toothpaste has been shown to have a positive effect on species of G+ lanceolate cocci, G- fusiform bacilli, round-headed G+ bacilli, curved G+ bacilli or G- filamentous formations. On the other hand, on G+ cocci in diplo and short chains and epithelial cells it did not show the desired efficiency, these being found in the highest percentage. This study once again shows the importance of microscopic examination in assessing the effect of some toothpastes on the weight of the oral flora.
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Vajrabhaya, La-ongthong, Suwanna Korsuwannawong, Choltacha Harnirattisai, and Chayada Teinchai. "Changes in the permeability and morphology of dentine surfaces after brushing with a Thai herbal toothpaste: A preliminary study." European Journal of Dentistry 10, no. 02 (2016): 239–44. http://dx.doi.org/10.4103/1305-7456.178319.
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ABSTRACT Objectives: The aim of this study was to evaluate dentine permeability after brushing with Twin Lotus®, Thai herbal toothpaste by comparing with Sensodyne Rapid Relief®, a commercial desensitizing toothpaste, and also after artificial saliva (AS) immersion or citric acid challenge. Materials and Methods: Dentine discs from human mandibular third molars were divided into three groups (n = 20) and brushed with either experimental toothpaste or water (control) for 2 min with an automated toothbrush. Then, 10 discs were immersed in AS, and the other 10 discs were immersed in 6% citric acid to simulate the conditions of the oral environment. The dentine permeability of each specimen was measured before brushing and after each treatment using a fluid filtration system. Morphological changes in the dentine were observed using scanning electron microscopy (SEM). Results: Both toothpastes significantly reduced dentine permeability, and a crystalline precipitate was observed on the dentine surface under SEM observation. No significant difference was found between the two toothpaste groups with regard to dentine permeability after brushing and AS or acid immersion. Conclusions: The dentine permeability reduction caused by the two toothpastes did not differ after brushing or after AS or citric acid immersion.
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Alonso, Roberta Caroline Bruschi, Letícia de Oliveira, Jaqueline Alves Batista Silva, et al. "Effectiveness of Bioactive Toothpastes against Dentin Hypersensitivity Using Evaporative and Tactile Analyses: A Randomized Clinical Trial." Oral 4, no. 1 (2024): 36–49. http://dx.doi.org/10.3390/oral4010004.
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The objective of this study was to investigate and compare the effectiveness of toothpastes containing bioactives to relieve dentin hypersensitivity with that of a commercial desensitizing toothpaste containing REFIX technology, associated or not with a calcium booster. In this double-blind, randomized, parallel-group, multi-center clinical trial, thirty-two volunteers diagnosed with dentin hypersensitivity and qualified to participate were randomized into four groups: (1) Colgate Sensitive Pro-Relief; (2) Sensodyne Repair & Relief; (3) Regenerador Sensitive; and (4) Regenerador Sensitive, associated with a calcium booster. Evaporative and tactile tests were used to check for dentin hypersensitivity in the test subjects. The participants brushed their teeth with one of the toothpastes, and dentin hypersensitivity was immediately tested using a visual analogue scale (VAS), in which the pain was rated on a scale of 0 to 10. Dentin hypersensitivity was measured after one week and after one month of the subjects continuing to use the toothpaste three times per day. Data were statistically analyzed with a non-parametric Friedman test for dependent data (α = 0.05). All toothpastes reduced dentin hypersensitivity. In the evaporative test, Sensodyne Protect & Repair and Regenerador Sensitive, associated with the calcium booster, exhibited faster and more effective results in reducing pain caused by dentin hypersensitivity, even after the first use. Colgate Sensitive Pro-Relief was effective only after one week of use. All toothpastes performed well in the tactile test for treating dentin hypersensitivity, and their performance improved over time. Sensodyne Repair & Protect presented the highest overall pain remission after one month (84.6%). The bioactive toothpastes reduced, to a different extent, the tooth hypersensitivity reported by the volunteers. Sensodyne Repair & Relief and Regenerador Sensitive, associated or not with a calcium booster, presented faster and more effective results in reducing pain caused by dentin hypersensitivity.
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Onwubu, Stanley Chibuzor, Phumlani Selby Mdluli, Shenuka Singh, Vishal Bharuth, and Mokgadi Ursula Makgobole. "Evaluation of the Occluding Characteristics of Nanosized Eggshell/Titanium Dioxide with or without Saliva." European Journal of Dentistry 13, no. 04 (2019): 547–55. http://dx.doi.org/10.1055/s-0039-1697726.
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Abstract Objectives The study reports on the effectiveness of a ball-milled nanosized titanium dioxide composite (EB@TiO2) for DH management in comparison with commercial desensitizing paste with and without saliva. Materials and Methods Forty-nine dentine specimens were prepared from extracted bovine anterior teeth. Twenty-one of the specimens were brushed with three desensitizing toothpaste for 7 days, namely: Group 1; EB@TiO2, Group 2; Colgate Pro-relief; and Group 3; Sensodyne repair (n = 7). Twenty-four specimens were brushed with the toothpaste for 7 days and stored in artificial saliva (control) after brushing. Each specimen was subsequently posttreated in citric acid solution to test its stability in acidic condition. Field scanning electron microscope was used to evaluate the effectiveness of the dentine tubules occlusion. The biocompatibility of the composite was tested using BHK21 cell line. Statistical Analysis One-way analysis of variance was used to analyze the percentage occluded area ratio values for all specimens (α = 0.05). Independent t-test was further used to evaluate the occlusion differences with saliva and without saliva. Results and Conclusions The number of dentine tubules decreased significantly after 7 days of brushing. Overall, the occlusion observe for EB@TiO2 were significantly better than for Colgate Pro-relief and Sensodyne repair (p < 0.05). BHK21 assay suggested that composite had no significant effect on the BHK21 cell line. This study demonstrated that the composite effectively occluded open dentine tubules within 7 days of brushing.
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Alves Teixeira, Raquel, Marcelo Henrick Matochek Maia, Pedro Luiz Santos Tomaz, et al. "Caracterização Físico-Química e Efetividade de Dentifrícios Dessensibilizantes na Redução da Permeabilidade Dentinária." Ensaios e Ciência C Biológicas Agrárias e da Saúde 25, no. 5-esp. (2022): 729–34. http://dx.doi.org/10.17921/1415-6938.2021v25n5-esp.p729-734.
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O uso de dentifrícios dessensibilizantes é uma opção prática e eficaz para minimizar a hipersensibilidade dentinária por obliterarem túbulos dentinários expostos. Objetivou-se avaliar in vitro a efetividade de dentifrícios dessensibilizantes na redução da permeabilidade dentinária após escovação e desafio erosivo. Trinta e seis discos de dentina bovina (1 mm espessura) foram escovados com escova elétrica (Oral-B Vitality Precision Clean rechargeable toothbrush) por dois minutos com os seguintes dentifrícios (n=9): Crest Colgate Pró-Alívio Imediato, Sensodyne Repair & Protect e Regenerador Diário DentalClean. A permeabilidade dentinária foi avaliada em 4 tempos experimentais: inicial (controle, não tratado), após a primeira escovação, após escovação diária por sete dias e após desafio ácido (ácido cítrico; 0,05M) por cinco minutos. Calculou-se a permeabilidade dentinária por condutividade hidráulica (em μl/min.cm H²O.cm²). Os dados foram analisados estatisticamente (ANOVA 2 critérios/Tukey (5%). A permeabilidade dentinária reduziu, significativamente, após a escovação inicial (p<0,05), à exceção do Regenerador Diário DentalClean, que apresentou permeabilidade similar ao controle. Após 7 dias, houve uma redução significativa na permeabilidade para todos os dentifrícios em relação ao controle (p<0.05). Porém, após o desafio erosivo, houve um aumento significativo da permeabilidade dentinária para o dentifrício Crest. Conclui-se a permeabilidade dentinária variou em função do tratamento, sendo todos dentifrícios efetivos após 7 dias; porém somente Colgate Pró-Alívio Imediato, Sensodyne Repair & Protect e Regenerador Diário DentalClean foram efetivos em manter reduzida a permeabilidade após desafio erosivo. Palavras-chave: Sensibilidade da Dentina. Erosão Dentária. Dentifrícios. Dentina. Abstract The use of desensitizing toothpastes is a practical and effective option to minimize dentinal hypersensitivity by obliterating exposed dentinal tubules. The objective was to evaluate in vitro the desensitizing gels effectiveness in reducing dentin permeability after brushing and erosion challenge. Thirty-six bovine dentin discs (1 mm thick) were brushed with an electric brush (2 minutes) with the following toothpastes (n = 9): Crest, Colgate Pro-Relief Immediate, Sensodyne Repair & Protect and DentalClean Daily Regenerator. Dentin permeability was evaluated in 4 experimental times: initial (control, untreated), after the first brushing, after daily brushing for 7 days and after acid challenge (citric acid; 0.05M) for 5 min. Dentin permeability was calculated by hydraulic conductivity (in μl / min.cm H²O.cm²). The data were analyzed statistically (ANOVA 2 criteria / Tukey (5%). The dentin permeability significantly decreased after the initial brushing (p <0.05), with the exception of Daily Regenerator which showed similar permeability to the control. After seven days, there was a significant reduction in the permeability for all gels compared to the control (p <0.05). However, after the erosive challenge, there was a significant increase in the dentin permeability for the toothpaste Crest, concluding the dentin permeability varied depending on the treatment, all of which were effective after 7 days, but only Colgate Pro-Relief, Sensodyne Repair & Protect, and Regenerador Diário DentalClean were effective in keeping the permeability reduced after an erosion challenge. Keywords: Dentin Sensitivity. Tooth Erosion. Dentifrices. Dentin.
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Alves Teixeira, Raquel, Marcelo Henrick Matochek Maia, Pedro Luiz Santos Tomaz, et al. "Caracterização Físico-Química e Efetividade de Dentifrícios Dessensibilizantes na Redução da Permeabilidade Dentinária." Ensaios e Ciência C Biológicas Agrárias e da Saúde 25, no. 5-esp (2022): 729–34. http://dx.doi.org/10.17921/1415-6938.2021v25n5-espp729-734.
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O uso de dentifrícios dessensibilizantes é uma opção prática e eficaz para minimizar a hipersensibilidade dentinária por obliterarem túbulos dentinários expostos. Objetivou-se avaliar in vitro a efetividade de dentifrícios dessensibilizantes na redução da permeabilidade dentinária após escovação e desafio erosivo. Trinta e seis discos de dentina bovina (1 mm espessura) foram escovados com escova elétrica (Oral-B Vitality Precision Clean rechargeable toothbrush) por dois minutos com os seguintes dentifrícios (n=9): Crest Colgate Pró-Alívio Imediato, Sensodyne Repair & Protect e Regenerador Diário DentalClean. A permeabilidade dentinária foi avaliada em 4 tempos experimentais: inicial (controle, não tratado), após a primeira escovação, após escovação diária por sete dias e após desafio ácido (ácido cítrico; 0,05M) por cinco minutos. Calculou-se a permeabilidade dentinária por condutividade hidráulica (em μl/min.cm H²O.cm²). Os dados foram analisados estatisticamente (ANOVA 2 critérios/Tukey (5%). A permeabilidade dentinária reduziu, significativamente, após a escovação inicial (p<0,05), à exceção do Regenerador Diário DentalClean, que apresentou permeabilidade similar ao controle. Após 7 dias, houve uma redução significativa na permeabilidade para todos os dentifrícios em relação ao controle (p<0.05). Porém, após o desafio erosivo, houve um aumento significativo da permeabilidade dentinária para o dentifrício Crest. Conclui-se a permeabilidade dentinária variou em função do tratamento, sendo todos dentifrícios efetivos após 7 dias; porém somente Colgate Pró-Alívio Imediato, Sensodyne Repair & Protect e Regenerador Diário DentalClean foram efetivos em manter reduzida a permeabilidade após desafio erosivo. Palavras-chave: Sensibilidade da Dentina. Erosão Dentária. Dentifrícios. Dentina. Abstract The use of desensitizing toothpastes is a practical and effective option to minimize dentinal hypersensitivity by obliterating exposed dentinal tubules. The objective was to evaluate in vitro the desensitizing gels effectiveness in reducing dentin permeability after brushing and erosion challenge. Thirty-six bovine dentin discs (1 mm thick) were brushed with an electric brush (2 minutes) with the following toothpastes (n = 9): Crest, Colgate Pro-Relief Immediate, Sensodyne Repair & Protect and DentalClean Daily Regenerator. Dentin permeability was evaluated in 4 experimental times: initial (control, untreated), after the first brushing, after daily brushing for 7 days and after acid challenge (citric acid; 0.05M) for 5 min. Dentin permeability was calculated by hydraulic conductivity (in μl / min.cm H²O.cm²). The data were analyzed statistically (ANOVA 2 criteria / Tukey (5%). The dentin permeability significantly decreased after the initial brushing (p <0.05), with the exception of Daily Regenerator which showed similar permeability to the control. After seven days, there was a significant reduction in the permeability for all gels compared to the control (p <0.05). However, after the erosive challenge, there was a significant increase in the dentin permeability for the toothpaste Crest, concluding the dentin permeability varied depending on the treatment, all of which were effective after 7 days, but only Colgate Pro-Relief, Sensodyne Repair & Protect, and Regenerador Diário DentalClean were effective in keeping the permeability reduced after an erosion challenge. Keywords: Dentin Sensitivity. Tooth Erosion. Dentifrices. Dentin.
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Cruz, Guilherme Ortiz Pinto, Larissa Martins Costa, Cesar Penazzo Lepri, Ruchele Dias Nogueira, Regina Guenka Palma-Dibb, and Vinícius Rangel Geraldo-Martins. "Color Stability and Surface Roughness of Hybrid and Nanofilled Composites Brushed with Abrasive Dentifrices." Journal of Health Sciences 23, no. 2 (2021): 85–91. http://dx.doi.org/10.17921/2447-8938.2021v23n2p85-91.
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AbstractThe aim of this study was to evaluate the color stability and the surface roughness of different composites brushed with toothpastes presenting different levels of abrasivity. Thirty discs of each material were obtained using michohybrid composites (Brilliant NG and Charisma Diamond) and a nanocomposite (Filtek Z350XT). The initial color (CIELab) and surface roughness (confocal laser scanning microscopy) of resin discs were evaluated. Afterwards, 10 specimens per group were brushed with the following dentifrices: Maximum Cavity Protection, Sensodyne Repair & Protect and Colgate Sensitive Pro-Relief. Brushing was performed with an electric toothbrush equipped with soft bristle head, with standard power and weight, for 30 minutes. Every 30 seconds, 1.0 ml of the slurry was injected between the bristles of the brush and the specimen. After abrasive challenge, the samples had their color and roughness reevaluated. Data were submitted to the Kruskal-Wallis test (color change) or the t-test (surface roughness). The level of significance was 5%. Results: Brushing did not significantly change the color of the composites tested in the study herein . On the other hand, the surface roughness of the composites was significantly affected by the abrasive challenge, regardless of the toothpaste used. The surface roughness change was similar for all the composites. The abrasive challenge with the toothpastes Maximum Cavity protection, Sensodyne Repair & Protect and Colgate Sensitive Pro-Relief was not able to significantly change the color of the composite resins. Nevertheless, the abrasive challenges significantly altered the surface roughness of all the evaluated composites. However, the changes in surface roughness were statistically similar in the microhybrid and nanofilled composites. Keywords: Composites Resins. Dentifrices. Color. ResumoO objetivo deste estudo foi avaliar a estabilidade de cor e a rugosidade superficial de diferentes resinas compostas escovadas com dentifrícios de diferentes níveis de abrasividade. Trinta discos de cada material foram obtidos utilizando compósitos micro-híbridos (Brilliant NG e Charisma Diamond) e um nanocompósito (Filtek Z350XT). A cor inicial (CIELab) e a rugosidade superficial (microscopia confocal de varredura a laser) dos discos de resina foram avaliadas. Em seguida, 10 amostras por grupo foram escovadas com os dentifrícios Máxima Proteção Anticáries, Sensodyne Repair & Protect e Colgate Sensitive Pro-Alívio. A escovação foi realizada com uma escova elétrica com cabeça de cerdas macias, com potência e peso padronizados, durante 30 minutos. A cada 30 segundos, 1,0 ml da pasta era injetada entre as cerdas da escova e a amostra. Após o desafio abrasivo, as amostras tiveram sua cor e rugosidade reavaliadas. Os dados foram submetidos ao teste de Kruskal-Wallis (alteração de cor) ou ao teste t (rugosidade da superfície) (α=5%). A escovação não alterou significativamente a cor dos compósitos. Por outro lado, a rugosidade superficial dos compósitos foi significativamente afetada pelo desafio abrasivo, independentemente do dentifrício utilizado. A alteração da rugosidade superficial foi semelhante para todos os compósitos. O desafio abrasivo com a Máxima Proteção Anticáries, o Sensodyne Repair & Protect e o Colgate Sensitive Pro-Alívio não foi capaz de alterar significativamente a cor das resinas. Diferentemente, os desafios abrasivos alteraram significativamente a rugosidade superficial de todos os compósitos avaliados. No entanto, as mudanças na rugosidade foram estatisticamente semelhantes nos compósitos micro-híbridos e nanoparticulado. Palavras-chave: Resinas Compostas. Dentifrícios. Cor.
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Das, Abhaya Chandra, Saurav Panda, Nihar Ranjan Sahoo, et al. "Comparison of Efficacy of Sensodyne Rapid Relief Containing Strontium Acetate with Placebo in the Management of Pain During Ultrasonic Scaling." South Eastern European Journal of Public Health, November 26, 2024, 2419–22. https://doi.org/10.70135/seejph.vi.2426.
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Introduction: Sensodyne Rapid Relief is a dentifrice containing 0.454% Stannous Fluoride as an active ingredient has a desensitizing effect observed over a period of 8 weeks. Aim: To assess the efficacy of the Sensodyne rapid relief toothpaste containing Stannous Fluoride as the active ingredient in relieving pain during the ultrasonic scaling procedure. Materials and Methods: This study is a randomized clinical placebo controlled trial with a split mouth design. A total of 50 patients were included in this study with informed consent. The respective contralateral areas with pain during ultrasonic scaling were identified and patient Visual Analogue Scale (VAS) was recorded. The selected contralateral areas were isolated. Test area was applied with Sensodyne Rapid Relief toothpaste (SRRT) and left in place for 5 minutes and the control area was applied with a placebo toothpaste (PT) with no active ingredient. Then ultrasonic scaling was done in both the test and control areas. The water and power control was kept constant throughout the study. During ultrasonic scaling, the patient visual analog scale (VAS) was recorded again for both the test and control areas. The statistical analysis was done using SPSS 20.0 software with significance fixed at 95 % CI (p <0.05).Results: The mean difference VAS scores between pre and post application for the test group (SRRT) was statistically significant higher (p < 0.001) than the control group (PT).Conclusion: SRRT containing 0.454% Stannous Fluoride (an active ingredient) can be effectively used to reduce pain and discomfort during the ultrasonic scaling procedure.
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Lee, Juhyun, Geumbit Hwang, Hyeri Gug, Ji-Hyun Lee, Su-Jin Park, and Joo-Cheol Park. "Desensitizing toothpastes for dentin sealing and tertiary dentin formation in vitro and in vivo: a comparative analysis." BMC Oral Health 22, no. 1 (2022). http://dx.doi.org/10.1186/s12903-022-02558-8.
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Abstract Background Dentin hypersensitivity is a painful response to external stimuli applied to exposed dentinal tubules. Various toothpastes with active desensitizing ingredients for the relief of dentin hypersensitivity are commercially available. However, data from several studies suggest that the effects of desensitizing toothpastes are unstable and brief. This study aimed to investigate the effect of toothpastes containing CPNE7-derived oligopeptide (CPNE7-DP) and other active desensitizing ingredients in the dentin microleakage, tubule occlusion and tertiary dentin formation. Methods Using scanning electron microscopy (SEM), we evaluated the patency of dentinal tubules on the surface of human dentin disks after brushing experiments with the various toothpastes. Dentin was histologically evaluated in a hypersensitivity model of canine teeth, after the exposed dentin area was brushed for 6 weeks. The toothpaste used in group 1 (control) did not contain any desensitizing ingredients; that used in group 2 contained CPNE7-DP; Colgate Sensitive was used in group 3; and Sensodyne Rapid Relief was used in group 4. Finally, we conducted microleakage analysis to investigate the dentin sealing effect. The microleakage analysis data were subjected to one-way ANOVA and post-hoc Tukey tests (alpha = 0.05). Results In the SEM images, all four groups of teeth exhibited partial occlusion of the dentinal tubules on the tooth surface. In the in vivo hypersensitivity model, group 2 exhibited a newly formed tertiary dentin, whereas no new hard tissue formation was observed in groups 1, 3, and 4. Microleakage analysis revealed that the volume of dentinal fluid flow was significantly smaller in group 2 than in group 1. Conclusions These results indicate that CPNE7-DP is a promising active ingredient with long-term dentin sealing effects.
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Dr, Sadia Riaz Dr. Reana Aslam Dr. Hafiz Muhammad Noman Baqa. "A CROSS-SECTIONAL RESEARCH TO INVESTIGATE THE WAYS TO REDUCE DENTINE HYPERSENSITIVITY THROUGH TOOTHPASTE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 10 (2019). https://doi.org/10.5281/zenodo.3519977.
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<strong><em>Objective: </em></strong><em>The objective of this research was to determine DH (Dentine Hypersensitivity) among young restricted their intake of edibles and drinks because of DH. </em> <strong><em>Patients and Methods: </em></strong><em>We carried out this cross-sectional research on fifty patients who consisted of males and females 25 each at Services Hospital, Lahore from October 2018 to January 2019. The selection of the sample was random in nature and these participants were selected based on reported hypersensitivity. Patients were divided into two groups who were respectively treated with Sensodyne Rapid Action and Colgate Total Care toothpaste. Visual Analog Scale was used for the measurement of hypersensitivity. Patients were included in the research after informed consent and they were also briefed about the research protocols. The ethical review committee also permitted to complete the research. </em> <strong><em>Results: </em></strong><em>Statistical analysis reflects that DH was present among all participants because of attachment loss or periodontal issues. Outcomes also present that use of toothpaste is effective in such cases. </em> <strong><em>Conclusion: </em></strong><em>Outcomes indicate that routine use of desensitizing toothpaste is very much effective to reduce the onset of DH among patients than those who are using toothpaste regularly. </em> <strong><em>Keywords: </em></strong><em>Attachment Loss, Dentine hypersensitivity (DH), Toothpaste, Sensodyne and Colgate. </em>
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Jang, Ji-Hyun, Soram Oh, Hyun-Jung Kim, and Duck-Su Kim. "A randomized clinical trial for comparing the efficacy of desensitizing toothpastes on the relief of dentin hypersensitivity." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-31616-6.
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AbstractThe 4-week double-blind clinical trial to manage dentin hypersensitivity (DH) using different desensitizing toothpastes was conducted. 53 participants with DH were enrolled in this trial. The participants were randomized into 3 groups: Group N; no active ingredient-containing toothpaste (Pleasia fluoride-free), Group SC; a toothpaste containing strontium chloride (Sensodyne Original), and Group TP; a toothpaste containing tricalcium phosphate (Vussen S). They were instructed to brush their teeth manually for 3 min, 3 times per day for 4 weeks with the allocated toothpastes, and were assessed at baseline (0), 2, and 4 weeks, respectively. Schiff sensitivity score was recorded to 3 different stimuli (air-blast, cold, and acid) at each assessment. Overall DH was also assessed using a visual analog scale (VAS). The longer participants used the toothpastes, the greater reduction in DH in all groups to the three stimuli. Group TP demonstrated significant reduction of DH compared to group N for air-blast and cold stimuli. Group TP showed significantly lower VAS than group N and SC. Tricalcium phosphate containing toothpaste used in this trial was most useful to reduce DH. It can be one of the treatment options that alleviate DH.
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"Clinical Efficacy Of BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In DH." Case Medical Research, January 30, 2020. http://dx.doi.org/10.31525/ct1-nct04249336.
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Arshad, Saba, Syed Jaffar Abbas Zaidi, and Waqas Ahmed Farooqui. "Comparative efficacy of BioMin-F, Colgate Sensitive Pro-relief and Sensodyne Rapid Action in relieving dentin hypersensitivity: a randomized controlled trial." BMC Oral Health 21, no. 1 (2021). http://dx.doi.org/10.1186/s12903-021-01864-x.
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Abstract Background Dentin hypersensitivity (DH) is a sharp toothache that influences a patients' oral health-related quality of life. Oral dentifrices have been marketed for pain relief within a minute for DH. The permanent management of DH is being investigated with the remineralisation potential of bioactive agents in dentinal tubules. This study investigated the relief from pain in DH in one minute after applying over the counter (OTC) dentifrices with Pro-Argin™ and strontium acetate and directly compared them with fluoro-calcium phospho-silicate (FCPS)-based dentifrices for immediate and sustained inhibition of painful stimulus provoking DH. Methods A randomised, controlled, triple-blinded clinical trial was conducted with 140 participants clinically diagnosed with DH and equally randomized into four groups with parallel treatment assignment of FCPS, Pro-Argin™, 8% strontium acetate, and sodium fluoride-based OTC dentifrices, and tested for DH with air blast, mechanical, and water jet stimuli on SCHIFF cold air sensitivity scale (SCASS) and visual analogue scale (VAS) at interim efficacy intervals of one minute, three days, two, four, and six weeks, subsequently. Results A total of 128 participants completed the trial. All the treatment groups showed statistically significant improvement in DH with p < 0.001 relative to baseline at all time points. Pro-Argin™ showed a greater reduction in DH with mean scores of (1.34 ± 0.68) (4.20 ± 1.70) (3.05 ± 2.17) followed by strontium acetate (1.57 ± 0.81) (4.65 ± 1.87) (3.75 ± 1.97) on SCASS and VAS for mechanical and water jet stimuli, one minute after application. There was no statistically significant treatment difference between the two (p = 0.499). FCPS showed the highest reduction in DH on SCASS and VAS for waterjet stimuli with mean scores of (0.97 ± 0.68) (1.80 ± 1.73) and Pro-Argin™ on VAS for mechanical stimuli with mean scores of (2.15 ± 1.92) in six weeks. Conclusion OTC dentifrices with Pro-argin™ and strontium acetate are effective for immediate pain relief from DH, and FCPS could be the best possible treatment option for long term management of DH. Trial registration ID: NCT04249336 (https://clinicaltrials.gov/ct2/show/NCT04249336), Date of Registration: January 30, 2020 (Retrospectively registered).
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Garcia, RM, WF Vieira-Junior, JD Theobaldo, et al. "Effect of Different Dentifrices, Bleaching with 35% Hydrogen Peroxide, and Red Wine on Surface Color and Roughness of Bovine Enamel." Current Dentistry 02 (August 17, 2020). http://dx.doi.org/10.2174/2542579x02999200817112951.
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Objective: To evaluate color and roughness of bovine enamel exposed to dentifrices, dental bleaching with 35% hydrogen peroxide (HP), and erosion/staining by red wine. Methods: Bovine enamel blocks were exposed to: artificial saliva (control), Oral-B Pro-Health (stannous fluoride with sodium fluoride, SF), Sensodyne Repair & Protect (bioactive glass, BG), Colgate Pro-Relief (arginine and calcium carbonate, AR), or Chitodent (chitosan, CHI). After toothpaste exposure, half (n=12) of the samples were bleached (35% HP), and the other half were not (n=12). The color (CIE L*a* b*, ΔE), surface roughness (Ra), and scanning electron microscopy were evaluated. Color and roughness were assessed at baseline, post-dentifrice and/or -dental bleaching, and after red wine. The data were subjected to analysis of variance (ANOVA) (ΔE) for repeated measures (Ra), followed by Tukey ́s test. The L*, a*, and b* values were analyzed by generalized linear models (a=0.05). Results: The HP promoted an increase in Ra values; however, the SF, BG, and AR did not enable this alteration. After red wine, all groups apart from SF (unbleached) showed increases in Ra values; SF and AR promoted decreases in L* values; AR demonstrated higher ΔE values, differing from the control; and CHI decreased the L* variation in the unbleached group. Conclusion: Dentifrices did not interfere with bleaching efficacy of 35% HP. However, dentifrices acted as a preventive agent against surface alteration from dental bleaching (BG, SF, and AR) or red wine (SF). Dentifrices can decrease (CHI) or increase (AR and SF) staining by red wine.