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Journal articles on the topic 'Sensor Activation'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Yu, Jerry. "Deflation-activated receptors, not classical inflation-activated receptors, mediate the Hering-Breuer deflation reflex." Journal of Applied Physiology 121, no. 5 (2016): 1041–46. http://dx.doi.org/10.1152/japplphysiol.00903.2015.

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Many airway sensory units respond to both lung inflation and deflation. Whether those responses to opposite stimuli come from one sensor (one-sensor theory) or more than one sensor (multiple-sensor theory) is debatable. One-sensor theory is commonly presumed in the literature. This article proposes a multiple-sensor theory in which a sensory unit contains different sensors for sensing different forces. Two major types of mechanical sensors operate in the lung: inflation- and deflation-activated receptors (DARs). Inflation-activated sensors can be further divided into slowly adapting receptors

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2

Michelson, Rhett, and Ted Weinert. "Sensor-less checkpoint activation?" Nature Cell Biology 1, no. 7 (1999): E177—E179. http://dx.doi.org/10.1038/15614.

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3

Zhang, Guohui, Yanyan Geng, Yakang Jin, et al. "Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels." Journal of General Physiology 149, no. 3 (2017): 373–87. http://dx.doi.org/10.1085/jgp.201611646.

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Large conductance Ca2+-activated K+ channels (BK channels) gate open in response to both membrane voltage and intracellular Ca2+. The channel is formed by a central pore-gate domain (PGD), which spans the membrane, plus transmembrane voltage sensors and a cytoplasmic gating ring that acts as a Ca2+ sensor. How these voltage and Ca2+ sensors influence the common activation gate, and interact with each other, is unclear. A previous study showed that a BK channel core lacking the entire cytoplasmic gating ring (Core-MT) was devoid of Ca2+ activation but retained voltage sensitivity (Budelli et al

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4

Qian, Xiang, Xiaowei Niu, and Karl L. Magleby. "Intra- and Intersubunit Cooperativity in Activation of BK Channels by Ca2+." Journal of General Physiology 128, no. 4 (2006): 389–404. http://dx.doi.org/10.1085/jgp.200609486.

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The activation of BK channels by Ca2+ is highly cooperative, with small changes in intracellular Ca2+ concentration having large effects on open probability (Po). Here we examine the mechanism of cooperative activation of BK channels by Ca2+. Each of the four subunits of BK channels has a large intracellular COOH terminus with two different high-affinity Ca2+ sensors: an RCK1 sensor (D362/D367) located on the RCK1 (regulator of conductance of K+) domain and a Ca-bowl sensor located on or after the RCK2 domain. To determine interactions among these Ca2+ sensors, we examine channels with eight d

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Horrigan, Frank T., and Zhongming Ma. "Mg2+ Enhances Voltage Sensor/Gate Coupling in BK Channels." Journal of General Physiology 131, no. 1 (2007): 13–32. http://dx.doi.org/10.1085/jgp.200709877.

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BK (Slo1) potassium channels are activated by millimolar intracellular Mg2+ as well as micromolar Ca2+ and membrane depolarization. Mg2+ and Ca2+ act in an approximately additive manner at different binding sites to shift the conductance–voltage (GK-V) relation, suggesting that these ligands might work through functionally similar but independent mechanisms. However, we find that the mechanism of Mg2+ action is highly dependent on voltage sensor activation and therefore differs fundamentally from that of Ca2+. Evidence that Ca2+ acts independently of voltage sensor activation includes an abili

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6

Sequeira, Gerald Joy, Robert Lugner, Ulrich Jumar, and Thomas Brandmeier. "A validation sensor based on carbon-fiber-reinforced plastic for early activation of automotive occupant restraint systems." Journal of Sensors and Sensor Systems 8, no. 1 (2019): 19–35. http://dx.doi.org/10.5194/jsss-8-19-2019.

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Abstract. In the automotive industry, sensors and sensor systems are one of the most important components in upcoming challenges like highly automated and autonomous driving. Forward-looking sensors (radar, lidar and cameras) have the technical capability to already provide important (pre-)crash information, such as the position of contact, relative crash velocity and overlap (width of contact) before the crash occurs. Future safety systems can improve crash mitigation with sophisticated vehicle safety strategies based on this information. One such strategy is an early activation of restraint

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7

Bartolini, Novella, Tiziana Calamoneri, Tom La Porta, Chiara Petrioli, and Simone Silvestri. "Sensor activation and radius adaptation (SARA) in heterogeneous sensor networks." ACM Transactions on Sensor Networks 8, no. 3 (2012): 1–34. http://dx.doi.org/10.1145/2240092.2240098.

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8

Horrigan, Frank T., and Richard W. Aldrich. "Coupling between Voltage Sensor Activation, Ca2+ Binding and Channel Opening in Large Conductance (BK) Potassium Channels." Journal of General Physiology 120, no. 3 (2002): 267–305. http://dx.doi.org/10.1085/jgp.20028605.

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To determine how intracellular Ca2+ and membrane voltage regulate the gating of large conductance Ca2+-activated K+ (BK) channels, we examined the steady-state and kinetic properties of mSlo1 ionic and gating currents in the presence and absence of Ca2+ over a wide range of voltage. The activation of unliganded mSlo1 channels can be accounted for by allosteric coupling between voltage sensor activation and the closed (C) to open (O) conformational change (Horrigan, F.T., and R.W. Aldrich. 1999. J. Gen. Physiol. 114:305–336; Horrigan, F.T., J. Cui, and R.W. Aldrich. 1999. J. Gen. Physiol. 114:2

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9

Kim, Jaemin, and Younghwan Yoo. "Sensor Node Activation Using Bat Algorithm for Connected Target Coverage in WSNs." Sensors 20, no. 13 (2020): 3733. http://dx.doi.org/10.3390/s20133733.

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This paper proposes a sensor node activation method using the nature-inspired algorithm (NIA) for the target coverage problem. The NIAs have been used to solve various optimization problems. This paper formulates the sensor target coverage problem into an object function and solves it with an NIA, specifically, the bat algorithm (BA). Although this is not the first attempt to use the BA for the coverage problem, the proposed method introduces a new concept called bat couple which consists of two bats. One bat finds sensor nodes that need to be activated for sensing, and the other finds nodes f

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10

Sheavly, Jonathan K., Jake I. Gold, Manos Mavrikakis, and Reid C. Van Lehn. "Molecular simulations of analyte partitioning and diffusion in liquid crystal sensors." Molecular Systems Design & Engineering 5, no. 1 (2020): 304–16. http://dx.doi.org/10.1039/c9me00126c.

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11

Sung, Youngchul, Xin Zhang, Lang Tong, and H. Vincent Poor. "Sensor Configuration and Activation for Field Detection in Large Sensor Arrays." IEEE Transactions on Signal Processing 56, no. 2 (2008): 447–63. http://dx.doi.org/10.1109/tsp.2007.907859.

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12

Zhou, Wei, Weiren Shi, Xiaogang Wang, and Kai Wang. "Adaptive Sensor Activation Algorithm for Target Tracking in Wireless Sensor Networks." International Journal of Distributed Sensor Networks 8, no. 6 (2012): 515906. http://dx.doi.org/10.1155/2012/515906.

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13

Chen, Jiming, Kejie Cao, Keyong Li, and Youxian Sun. "Distributed sensor activation algorithm for target tracking with binary sensor networks." Cluster Computing 14, no. 1 (2009): 55–64. http://dx.doi.org/10.1007/s10586-009-0092-0.

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14

Yang, Wen, Guanrong Chen, Xiaofan Wang, and Ling Shi. "Stochastic sensor activation for distributed state estimation over a sensor network." Automatica 50, no. 8 (2014): 2070–76. http://dx.doi.org/10.1016/j.automatica.2014.05.025.

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15

Jaggi, Neeraj, Sreenivas Madakasira, Sandeep Reddy Mereddy, and Ravi Pendse. "Adaptive algorithms for sensor activation in renewable energy based sensor systems." Ad Hoc Networks 11, no. 4 (2013): 1405–20. http://dx.doi.org/10.1016/j.adhoc.2011.04.008.

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16

Banoth, Balaji, Shraddha Tuladhar, Rajendra Karki, et al. "ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)." Journal of Biological Chemistry 295, no. 52 (2020): 18276–83. http://dx.doi.org/10.1074/jbc.ra120.015924.

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Candida albicans and Aspergillus fumigatus are dangerous fungal pathogens with high morbidity and mortality, particularly in immunocompromised patients. Innate immune-mediated programmed cell death (pyroptosis, apoptosis, necroptosis) is an integral part of host defense against pathogens. Inflammasomes, which are canonically formed upstream of pyroptosis, have been characterized as key mediators of fungal sensing and drivers of proinflammatory responses. However, the specific cell death pathways and key upstream sensors activated in the context of Candida and Aspergillus infections are unknown

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17

Watkins, Kenneth, and Stephanie Steelman. "New Capacitive Thermal Age Tag for Predicting Remaining Thermal Life of Multiple Products." Annual Conference of the PHM Society 12, no. 1 (2020): 10. http://dx.doi.org/10.36001/phmconf.2020.v12i1.1303.

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This paper proposes use of a new capacitive thermal age sensor that inherently integrates time and temperature without batteries or electronic memory to predict the remaining thermal life of a wide range of monitored products. The sensor is a tiny capacitor comprising a polymeric dielectric between two conductive plates. Capacitance of the sensor increases during thermal aging due to shrinkage of the polymer. Additives such as catalysts adjust the activation energy (Ea) of capacitance change with thermal age.A thermal age tag, incorporating two capacitive sensors of different activation energy

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18

Shuk, Pavel, and Robert Jantzt. "Zirconia potentiometric oxygen sensor activation using NEMCA." International Journal on Smart Sensing and Intelligent Systems 7, no. 5 (2020): 1–4. http://dx.doi.org/10.21307/ijssis-2019-036.

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19

Carrara, Marta, Filippo Prischi, and Maruf Ali. "UPR Signal Activation by Luminal Sensor Domains." International Journal of Molecular Sciences 14, no. 3 (2013): 6454–66. http://dx.doi.org/10.3390/ijms14036454.

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20

Coyle, Candace M., Mrinalini Puranik, Hwan Youn, et al. "Activation Mechanism of the CO Sensor CooA." Journal of Biological Chemistry 278, no. 37 (2003): 35384–93. http://dx.doi.org/10.1074/jbc.m301000200.

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21

Delemotte, Lucie, Vincenzo Carnevale, Michael L. Klein, Marina A. Kasimova, and Mounir Tarek. "Molecular Determinants of Voltage Sensor Domain Activation." Biophysical Journal 108, no. 2 (2015): 427a. http://dx.doi.org/10.1016/j.bpj.2014.11.2336.

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22

Andres, M. V., K. W. H. Foulds, and M. J. Tudor. "Optical activation of a silicon vibrating sensor." Electronics Letters 22, no. 21 (1986): 1097. http://dx.doi.org/10.1049/el:19860752.

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23

Li, Sheng, Tamara Tsalkova, Mark A. White, et al. "Mechanism of Intracellular cAMP Sensor Epac2 Activation." Journal of Biological Chemistry 286, no. 20 (2011): 17889–97. http://dx.doi.org/10.1074/jbc.m111.224535.

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24

Jaggi, Neeraj, Koushik Kar, and Ananth Krishnamurthy. "Rechargeable sensor activation under temporally correlated events." Wireless Networks 15, no. 5 (2007): 619–35. http://dx.doi.org/10.1007/s11276-007-0091-0.

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25

Yan, Nieng, and Yigong Shi. "Allosteric Activation of a Bacterial Stress Sensor." Cell 131, no. 3 (2007): 441–43. http://dx.doi.org/10.1016/j.cell.2007.10.021.

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26

Sharma, Meenakshi, and Eva de Alba. "Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes." International Journal of Molecular Sciences 22, no. 2 (2021): 872. http://dx.doi.org/10.3390/ijms22020872.

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The inflammasome is a three-component (sensor, adaptor, and effector) filamentous signaling platform that shields from multiple pathogenic infections by stimulating the proteolytical maturation of proinflammatory cytokines and pyroptotic cell death. The signaling process initiates with the detection of endogenous and/or external danger signals by specific sensors, followed by the nucleation and polymerization from sensor to downstream adaptor and then to the effector, caspase-1. Aberrant activation of inflammasomes promotes autoinflammatory diseases, cancer, neurodegeneration, and cardiometabo

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27

Carrasquel-Ursulaez, Willy, Gustavo F. Contreras, Romina V. Sepúlveda, et al. "Hydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel." Journal of General Physiology 145, no. 1 (2014): 61–74. http://dx.doi.org/10.1085/jgp.201411194.

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Large-conductance Ca2+- and voltage-activated K+ channel (BK) open probability is enhanced by depolarization, increasing Ca2+ concentration, or both. These stimuli activate modular voltage and Ca2+ sensors that are allosterically coupled to channel gating. Here, we report a point mutation of a phenylalanine (F380A) in the S6 transmembrane helix that, in the absence of internal Ca2+, profoundly hinders channel opening while showing only minor effects on the voltage sensor active–resting equilibrium. Interpretation of these results using an allosteric model suggests that the F380A mutation great

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28

Qomaruddin, Cristian Fàbrega, Andreas Waag, et al. "Visible Light Activated Room Temperature Gas Sensors Based on CaFe2O4 Nanopowders." Proceedings 2, no. 13 (2018): 834. http://dx.doi.org/10.3390/proceedings2130834.

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Gas sensors based on CaFe2O4 nanopowders, which are p–type metal oxide semiconductor (MOX), have been fabricated and assessed for ethanol gas monitoring under visible light activation at room temperature. Regardless of their inferior sensitivity compared to thermally activated counterparts, the developed sensors have shown responsive sensing behavior towards ethanol vapors confirming the ability of using visible light for sensor activation. LEDs with different wavelengths (i.e., 465–590 nm) were employed. The highest sensitivity (3.7%) was reached using green LED activation that corresponds to

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29

Li, Wei. "Camera Sensor Activation Scheme for Target Tracking in Wireless Visual Sensor Networks." International Journal of Distributed Sensor Networks 9, no. 4 (2013): 397537. http://dx.doi.org/10.1155/2013/397537.

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30

Di Micco, Antonia, Gianluca Frera, Jérôme Lugrin, et al. "AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity." Proceedings of the National Academy of Sciences 113, no. 32 (2016): E4671—E4680. http://dx.doi.org/10.1073/pnas.1602419113.

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Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the immune system by activating inflammatory caspases and cytokines such as IL-1β. The nature of endogenous stress signals that activate inflammasomes remains unclear. Here we show that an inhibitor of the HIV aspartyl protease, Nelfinavir, triggers inflammasome formation and elicits an IL-1R–dependent inflammation in mice. We found that Nelfinavir impaired the maturation of lamin A, a structural component of the nuclear envelope, thereby promoting the release of DNA in the cytosol. Moreover, deficiency of

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31

Stroberg, Wylie, Hadar Aktin, Yonatan Savir, and Santiago Schnell. "How to design an optimal sensor network for the unfolded protein response." Molecular Biology of the Cell 29, no. 25 (2018): 3052–62. http://dx.doi.org/10.1091/mbc.e18-01-0060.

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Cellular protein homeostasis requires continuous monitoring of stress in the endoplasmic reticulum (ER). Stress-detection networks control protein homeostasis by mitigating the deleterious effects of protein accumulation, such as aggregation and misfolding, with precise modulation of chaperone production. Here, we develop a coarse model of the unfolded protein response in yeast and use multi-objective optimization to determine which sensing and activation strategies optimally balance the trade-off between unfolded protein accumulation and chaperone production. By comparing a stress-sensing mec

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32

DeFilippis, Victor R., David Alvarado, Tina Sali, Stefan Rothenburg, and Klaus Früh. "Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1." Journal of Virology 84, no. 1 (2009): 585–98. http://dx.doi.org/10.1128/jvi.01748-09.

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ABSTRACT Human cytomegalovirus (HCMV) is a member of the betaherpesvirus family that, unlike other herpesviruses, triggers a strong innate immune response in infected cells that includes transcription of the beta interferon gene via activation of interferon regulatory factor 3 (IRF3). IRF3 activation requires signaling from pattern recognition receptors that is initiated by their interaction with specific pathogen-associated molecules. However, while IRF3-activating pathways are increasingly well characterized, the cellular molecules involved in HCMV-mediated IRF3-dependent beta interferon tra

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33

Shelley, Christopher, Xiaowei Niu, Yanyan Geng, and Karl L. Magleby. "Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+." Journal of General Physiology 135, no. 5 (2010): 461–80. http://dx.doi.org/10.1085/jgp.200910331.

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Voltage-dependent gating mechanisms of large conductance Ca2+ and voltage-activated (BK) channels were investigated using two-dimensional maximum likelihood analysis of single-channel open and closed intervals. To obtain sufficient data at negative as well as positive voltages, single-channel currents were recorded at saturating Ca2+ from BK channels mutated to remove the RCK1 Ca2+ and Mg2+ sensors. The saturating Ca2+ acting on the Ca2+ bowl sensors of the resulting BKB channels increased channel activity while driving the gating into a reduced number of states, simplifying the model. Five hi

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34

Tobi, Markus Dwiyanto. "RANCANG BANGUN ROBOT BERODA PEMADAM API MENGGUNAKAN ARDUINO UNO REV.1.3." Electro Luceat 1, no. 1 (2015): 52–61. http://dx.doi.org/10.32531/jelekn.v1i1.16.

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Frequent fire accident has caused many casualties and property losses . There is a risk that must be borne by the time firefighters extinguish a fire in a room such as falling objects falling from the roof of a building or fire getting bigger . In this final project will be made prototypes of fire fighting robot by taking an example of a simulated fire in the arena . This robot designed to operate using four types of sensors , including a sound sensor activation to signal the start-up time in activating the robot , ultrasonic sensor for distance detection , Uvtron sensor detection for the pres

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35

Patan, Maciej. "Distributed scheduling of sensor networks for identification of spatio-temporal processes." International Journal of Applied Mathematics and Computer Science 22, no. 2 (2012): 299–311. http://dx.doi.org/10.2478/v10006-012-0022-9.

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Distributed scheduling of sensor networks for identification of spatio-temporal processesAn approach to determine a scheduling policy for a sensor network monitoring some spatial domain in order to identify unknown parameters of a distributed system is discussed. Given a finite number of possible sites at which sensors are located, the activation schedule for scanning sensors is provided so as to maximize a criterion defined on the Fisher information matrix associated with the estimated parameters. The related combinatorial problem is relaxed through operating on the density of sensors in lieu

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36

Krishnamurthy, V., M. Maskery, and G. Yin. "Decentralized Adaptive Filtering Algorithms for Sensor Activation in an Unattended Ground Sensor Network." IEEE Transactions on Signal Processing 56, no. 12 (2008): 6086–101. http://dx.doi.org/10.1109/tsp.2008.929664.

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37

Tanwar, Anand, Ajay K. Sharma, and R. Vinay Shankar Pandey. "Fractional-Grasshopper Optimization Algorithm for the Sensor Activation Control in Wireless Sensor Networks." Wireless Personal Communications 113, no. 1 (2020): 399–422. http://dx.doi.org/10.1007/s11277-020-07206-4.

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38

Zheng, Jin, Md Zakirul Alam Bhuiyan, Shaohua Liang, Xiaofei Xing, and Guojun Wang. "Auction-based adaptive sensor activation algorithm for target tracking in wireless sensor networks." Future Generation Computer Systems 39 (October 2014): 88–99. http://dx.doi.org/10.1016/j.future.2013.12.014.

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39

Kim, Hyunsook, and EunHwa Kim. "Hop-based Activation Scheduling in Wireless Sensor Networks." International Journal of Multimedia and Ubiquitous Engineering 9, no. 4 (2014): 1–12. http://dx.doi.org/10.14257/ijmue.2014.9.4.01.

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40

Wang, Weilin, Stéphane Lafortune, Anouck R. Girard, and Feng Lin. "Optimal sensor activation for diagnosing discrete event systems." Automatica 46, no. 7 (2010): 1165–75. http://dx.doi.org/10.1016/j.automatica.2010.04.004.

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41

Bazzazi, Hojjat, Lingjie Sang, and David T. Yue. "FRET-Based Genetically Encoded Sensor of Calcineurin Activation." Biophysical Journal 104, no. 2 (2013): 530a. http://dx.doi.org/10.1016/j.bpj.2012.11.2930.

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42

Wang, Weilin. "Online minimization of sensor activation for supervisory control." Automatica 73 (November 2016): 8–14. http://dx.doi.org/10.1016/j.automatica.2016.06.016.

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43

Patel, Jenish R., and Adolfo García-Sastre. "Activation and regulation of pathogen sensor RIG-I." Cytokine & Growth Factor Reviews 25, no. 5 (2014): 513–23. http://dx.doi.org/10.1016/j.cytogfr.2014.08.005.

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44

Cho, Youngtak, Viet Anh Pham Ba, Jin-Young Jeong, Yoonji Choi, and Seunghun Hong. "Ion-Selective Carbon Nanotube Field-Effect Transistors for Monitoring Drug Effects on Nicotinic Acetylcholine Receptor Activation in Live Cells." Sensors 20, no. 13 (2020): 3680. http://dx.doi.org/10.3390/s20133680.

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We developed ion-selective field-effect transistor (FET) sensors with floating electrodes for the monitoring of the potassium ion release by the stimulation of nicotinic acetylcholine receptors (nAChRs) on PC12 cells. Here, ion-selective valinomycin-polyvinyl chloride (PVC) membranes were coated on the floating electrode-based carbon nanotube (CNT) FETs to build the sensors. The sensors could selectively measure potassium ions with a minimum detection limit of 1 nM. We utilized the sensor for the real-time monitoring of the potassium ion released from a live cell stimulated by nicotine. Notabl

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Baris, Adrian M., Eugenia Fraile-Bethencourt, and Sudarshan Anand. "Nucleic Acid Sensing in the Tumor Vasculature." Cancers 13, no. 17 (2021): 4452. http://dx.doi.org/10.3390/cancers13174452.

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Endothelial cells form a powerful interface between tissues and immune cells. In fact, one of the underappreciated roles of endothelial cells is to orchestrate immune attention to specific sites. Tumor endothelial cells have a unique ability to dampen immune responses and thereby maintain an immunosuppressive microenvironment. Recent approaches to trigger immune responses in cancers have focused on activating nucleic acid sensors, such as cGAS-STING, in combination with immunotherapies. In this review, we present a case for targeting nucleic acid-sensing pathways within the tumor vasculature t

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46

Samotaev, Nikolay, and Alexey Vasiliev. "Mixed Cerium/Zirconium Oxide as a Material for Carbon Monoxide Thermocatalytic Gas Sensor." Proceedings 2, no. 13 (2018): 841. http://dx.doi.org/10.3390/proceedings2130841.

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The perspective catalysts usable for the fabrication of thermocatalytic gas sensors were studied. The analysis of CO oxidation kinetics by Pd decorated Al2O3, ZSM-5, SnO2, CeO2/ZrO2 and some other carriers of catalysts showed that the application of these catalysts leads to the ambiguity of sensor response (light-off effect). It was demonstrated that a catalyst based on CeO2/ZrO2 carrier could be used for the fabrication of sensors characterized by the univocal correspondence between CO concentration and sensor response. The developed model of the CO oxidation on all Pd catalysts with inert ca

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47

Geng, Yanyan, Zengqin Deng, Guohui Zhang та ін. "Coupling of Ca2+and voltage activation in BK channels through the αB helix/voltage sensor interface". Proceedings of the National Academy of Sciences 117, № 25 (2020): 14512–21. http://dx.doi.org/10.1073/pnas.1908183117.

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Large-conductance Ca2+and voltage-activated K+(BK) channels control membrane excitability in many cell types. BK channels are tetrameric. Each subunit is composed of a voltage sensor domain (VSD), a central pore-gate domain, and a large cytoplasmic domain (CTD) that contains the Ca2+sensors. While it is known that BK channels are activated by voltage and Ca2+, and that voltage and Ca2+activations interact, less is known about the mechanisms involved. We explore here these mechanisms by examining the gating contribution of an interface formed between the VSDs and the αB helices located at the t

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48

Nesa, Nashreen, and Indrajit Banerjee. "SensorRank: An Energy Efficient Sensor Activation Algorithm for Sensor Data Fusion in Wireless Networks." IEEE Internet of Things Journal 6, no. 2 (2019): 2532–39. http://dx.doi.org/10.1109/jiot.2018.2871469.

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49

Wang, Caroline K., Shawn M. Lamothe, Alice W. Wang, Runying Y. Yang, and Harley T. Kurata. "Pore- and voltage sensor–targeted KCNQ openers have distinct state-dependent actions." Journal of General Physiology 150, no. 12 (2018): 1722–34. http://dx.doi.org/10.1085/jgp.201812070.

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Ion channels encoded by KCNQ2-5 generate a prominent K+ conductance in the central nervous system, referred to as the M current, which is controlled by membrane voltage and PIP2. The KCNQ2-5 voltage-gated potassium channels are targeted by a variety of activating compounds that cause negative shifts in the voltage dependence of activation. The underlying pharmacology of these effects is of growing interest because of possible clinical applications. Recent studies have revealed multiple binding sites and mechanisms of action of KCNQ activators. For example, retigabine targets the pore domain, b

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50

Gruslova, Aleksandra, Iurii Semenov та Bin Wang. "An extracellular domain of the accessory β1 subunit is required for modulating BK channel voltage sensor and gate". Journal of General Physiology 139, № 1 (2011): 57–67. http://dx.doi.org/10.1085/jgp.201110698.

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Abstract:

A family of tissue-specific auxiliary β subunits modulates large conductance voltage- and calcium-activated potassium (BK) channel gating properties to suit their diverse functions. Paradoxically, β subunits both promote BK channel activation through a stabilization of voltage sensor activation and reduce BK channel openings through an increased energetic barrier of the closed-to-open transition. The molecular determinants underlying β subunit function, including the dual gating effects, remain unknown. In this study, we report the first identification of a β1 functional domain consisting of Y

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