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1
Forli, F., S. Passetti, M. Mancuso, et al. "Mitochondrial Syndromic Sensorineural Hearing Loss." Bioscience Reports 27, no. 1-3 (2007): 113–23. http://dx.doi.org/10.1007/s10540-007-9040-5.
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Mitochondrial diseases (MD) are a clinically heterogeneous group of disorders that arise as a result of dysfunction of the mitochondrial respiratory chain. Sensorineural hearing loss (SNHL) is often associated to mitochondrial dysfunctions both in syndromic, nonsyndromic forms. SNHL has been described in association to different mitochondrial multisystemic syndromes, often characterized by an important neuromuscular involvement. Because of the clinical relevance of the associated neurological symptoms, the occurrence of SNHL is often underestimated and undiagnosed. In this study we evaluated the incidence of SNHL in a group of 17 patients with MD. We detected some degree of hearing impairment in 8/17 patients (47%), thus confirming the frequency of hearing impairment in MD. Furthermore, we want to highlight the role of the audiologist and otolaryngologist in the diagnosis and characterization of a MD, which should be suspected in all the cases in which the hearing loss is associated to signs and symptoms characteristic of mitochondrial dysfunction, especially if the family history is positive for hearing loss or MD in the maternal line.
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Thomas, Ratna, Mohan Kameswaran, Vel Murugan, and B. C. Okafor. "Sensorineural hearing loss in neurobrucellosis." Journal of Laryngology & Otology 107, no. 11 (1993): 1034–36. http://dx.doi.org/10.1017/s0022215100125198.
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AbstractA case of neurobrucellosis presenting to the otologist with sensorineural hearing loss (SNHL) as the predominant clinical feature is reported. The diagnostic features and treatment options are discussed and the need for prolonged combination treatment to prevent relapse and further deterioration of hearing stressed. SNHL in neurobrucellosis has hitherto been reported principally in neurology literature as something of an incidental finding and so escapes the attention of otologists. It is hoped that this report will alert otologists in areas where brucellosis is endemic to the need to include tests for brucellosis in the routine diagnostic screening for SNHL. Practitioners in other locations should also consider this possibility when dealing with patients who have visited or lived in endemic regions.
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Kalogianni, Vasiliki, Fotios Vlahos, and Iosifina Giannakikou. "Postoperative sensorineural hearing loss in a non-otological surgery secondary to a dural tear after spinal surgery." BMJ Case Reports 18, no. 6 (2025): e264032. https://doi.org/10.1136/bcr-2024-264032.
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This case involves a woman in her 70s with a complex history of spinal surgeries and pre-existing left-sided sensorineural hearing loss (SNLH), who underwent elective spondylodesis for failed back surgery syndrome. Postoperatively, the patient complained of sudden onset, profound and painless hearing loss. Otorhinolaryngology (ENT) review confirmed bilateral sensorineural hearing loss. A large dural tear causing cerebral spinal fluid (CSF) leak was diagnosed. The CSF leak failed to heal with conservative management and required subsequent surgical repair. The SNHL was attributed to the drop in CSF pressure causing a disruption of the endolymph/perilymph balance. The patient made a complete recovery after a short course of intravenous steroids. SNHL is a documented but rare adverse event in non-otological surgeries. This manuscript stresses the importance of anaesthesiologists being aware of such a complication in high-risk patients. It also highlights modifiable factors to prevent SNHL and discusses possible treatments.
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Ronner, Evette A., Liliya Benchetrit, Patricia Levesque, Razan A. Basonbul, and Michael S. Cohen. "Quality of Life in Children with Sensorineural Hearing Loss." Otolaryngology–Head and Neck Surgery 162, no. 1 (2019): 129–36. http://dx.doi.org/10.1177/0194599819886122.
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Objective To assess quality of life (QOL) in pediatric patients with sensorineural hearing loss (SNHL) with the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) and the Hearing Environments and Reflection on Quality of Life 26 (HEAR-QL-26) and HEAR-QL-28 surveys. Study Design Prospective longitudinal study. Setting Tertiary care center. Subjects and Methods Surveys were administered to patients with SNHL (ages 2-18 years) from July 2016 to December 2018 at a multidisciplinary hearing loss clinic. Patients aged >7 years completed the HEAR-QL-26, HEAR-QL-28, and PedsQL 4.0 self-report tool, while parents completed the PedsQL 4.0 parent proxy report for children aged ≤7 years. Previously published data from children with normal hearing were used for controls. The independent t test was used for analysis. Results In our cohort of 100 patients, the mean age was 7.7 years (SD, 4.5): 62 participants had bilateral SNHL; 63 had mild to moderate SNHL; and 37 had severe to profound SNHL. Sixty-eight patients used a hearing device. Mean (SD) total survey scores for the PedsQL 4.0 (ages 2-7 and 8-18 years), HEAR-QL-26 (ages 7-12 years), and HEAR-QL-28 (ages 13-18 years) were 83.9 (14.0), 79.2 (11.1), 81.2 (9.8), and 77.5 (11.3), respectively. Mean QOL scores for patients with SNHL were significantly lower than those for controls on the basis of previously published normative data ( P < .0001). There was no significant difference in QOL between children with unilateral and bilateral SNHL or between children with SNHL who did and did not require a hearing device. Low statistical power due to small subgroup sizes limited our analysis. Conclusion It is feasible to collect QOL data from children with SNHL in a hearing loss clinic. Children with SNHL had significantly lower scores on validated QOL instruments when compared with peers with normal hearing.
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Volta, Umberto, Gian Gaetano Ferri, Roberto De Giorgio, et al. "Sensorineural Hearing Loss and Celiac Disease: A Coincidental Finding." Canadian Journal of Gastroenterology 23, no. 8 (2009): 531–35. http://dx.doi.org/10.1155/2009/540675.
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BACKGROUND: Celiac disease (CD) can be associated with a variety of extraintestinal manifestations, including neurological diseases. A new neurological correlation has been found between CD and sensorineural hearing loss (SNHL).OBJECTIVE: To verify the association between SNHL and CD, and to establish whether the neurological hearing impairment in CD is related to nonorgan-specific and antineuronal antibodies, as well as the presence of autoimmune disorders.METHODS: A sample of 59 consecutive biopsy- and serologically proven CD patients were studied. Among CD patients, 11 were newly diagnosed and 48 were on a gluten-free diet. Hearing function was assessed by audiometric analysis in all CD patients as well as in 59 age- and sex-matched controls. Patients were tested for a panel of immune markers including nonorgan-specific autoantibodies and antineuronal antibodies.RESULTS: SNHL was detected in five CD patients (8.5%) and in two controls (3.4%). In one patient, the SNHL was bilateral, whereas the remaining four had a monolateral impairment. The prevalence of SNHL was not significantly different between CD patients and controls. At least one of the antibodies tested for was positive in two of the five CD patients with SNHL and in 12 of the 54 CD patients without SNHL. Antineuronal antibodies to central nervous system antigens were consistently negative in the five CD patients with SNHL. Only one of the five CD patients with SNHL had Hashimoto thyroiditis.CONCLUSIONS: SNHL and CD occur coincidentally. Hearing function should be assessed only in CD patients with clinical signs of hearing deficiency.
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Shen, Yanxiong, Yiwen Chen, and Yuanhui Zhang. "Advances in MicroRNA in Sensorineural Hearing Loss." International Journal of Biology and Life Sciences 10, no. 1 (2025): 25–29. https://doi.org/10.54097/vwvrbm90.
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Hearing loss is one of the global health burdens, and the increased risk of communication barriers, social isolation and depression poses a significant threat to the quality of life of patients. A report by the World Health Organization (WHO) estimated that about 466 million people worldwide are affected by disabling hearing loss, of which 34 million are children [1]. Among them, Sensorineural Hearing Loss (SNHL) is one of the common types of hearing loss with a complex pathogenesis, which is usually caused by damage to cochlear sensory hair cells (HCs). Current treatments for SNHL focus on amplifying sound through hearing aids or electrically stimulating auditory neurons through cochlear implantation (CI) for severe to profound deafness; however, neither approach restores the intrinsic sensory hair cells of the inner ear [2]. In recent years, MicroRNAs (Micro Ribonucleic Acids, miRNAs), as key regulatory molecules of gene expression, are involved in the growth and development of cochlear hair cells, and their role in SNHL has gradually become a hot research topic. In this paper, we systematically review the experimental research progress and clinical application potential of miRNAs in SNHL, including the diagnostic value of miRNAs as biomarkers, and the regulatory mechanism in cochlear cell damage and repair, which is helpful to solve the clinical problems of hearing loss.
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Noskova, V. V., and A. N. Khrabrikov. "Correlation between endothelial dysfunction and sensorineural hearing loss." Russian Bulletin of Otorhinolaryngology 90, no. 3 (2025): 13. https://doi.org/10.17116/otorino20259003113.
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Objective. To investigate the characteristics of blood markers of endothelial dysfunction (ED) in patients with sensorineural hearing loss (SNHL) and in normally hearing people, to evaluate the correlation of the data obtained with SNHL degree based on the results of tonal threshold audiometry in the studied groups. Material and methods. Auditory function was studied in 94 people, including patients with chronic CHT (n=32), patients with acute CHT (n=32), and normally hearing subjects (n=30). Hearing assessment was carried out by recording tonal threshold audiometry, laboratory parameters were assessed by enzyme immunoassay (ELISA) and the biochemical method. Statistical processing was carried out using the Microsoft Excel 13 software package. Results. The study of biomarkers of endothelial dysfunction revealed that SNHL is characterized by impaired motor and adhesive function of vascular endothelium. Acute SNHL is more often characterized by an increase in the blood serum of the marker of vasospasm, endothelin-1 (ET-1), with the highest values (more than 0.5 pg/ml) detected in grade I and III hearing loss. On the contrary, chronic SNHL is characterized by an increase in blood serum markers of vascular endothelial adhesion disorders, namely fibrinogen and vascular endothelial adhesion molecules-1 (VCAM-1). Moreover, the highest values (more than 60 ng/ml) of the latter are found in grade II and III chronic SNHL.
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Vivek, V. Harkare, V. Deosthale Nitin, P. Khadakkar Sonali, R. Dhoke Priti, S. Dhote Kanchan, and Gupta Ashish. "SNHL in Diabetics: A Prospective Study." PJSR 7, no. 2 (2014): 38–42. https://doi.org/10.5281/zenodo.8251976.
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The aim of this study was to assess the hearing threshold level in patients of diabetes mellitus, correlate degree of hearing loss with duration and severity of hyperglycemia and complications of diabetes mellitus. This prospective longitudinal study was carried out from November 2007 to October 2009. Patients of previously diagnosed cases of diabetes mellitus below 60 years of age were subjected to fasting and post-meal blood sugar levels and Pure Tone Audiometric tests. Seventy four percent diabetics were affected with sensorineural hearing loss. There was no statistically significant association between the age and the sex of diabetic patients with hearing loss. The results showed bilateral significantly high frequency, mild to moderate sensorineural hearing loss in uncontrolled diabetics as compared to those with controlled diabetes (p=0.001). Diabetics with poorly controlled blood sugar level have increased risk of hearing loss
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Gupta, Santosh. "Imaging for Sensorineural Hearing Loss." An International Journal of Otorhinolaryngology Clinics 2, no. 2 (2010): 113–24. http://dx.doi.org/10.5005/jp-journals-10003-1024.
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Abstract There are several causes of sensorineural hearing loss (SNHL), in some of which imaging plays an important role for diagnosis and further management. We present an elaborate imaging based pictorial depiction of the various findings in these cases mainly based on CT and MRI imaging.
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Dahle, Arthur J., Karen B. Fowler, John D. Wright, Suresh B. Boppana, William J. Britt, and Robert F. Pass. "Longitudinal Investigation of Hearing Disorders in Children with Congenital Cytomegalovirus." Journal of the American Academy of Audiology 11, no. 05 (2000): 283–90. http://dx.doi.org/10.1055/s-0042-1748054.
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AbstractThis investigation consisted of a longitudinal study of the effects of congenital cytomegalovirus (CMV) infection on hearing sensitivity in 860 children with documented asymptomatic or symptomatic congenital CMV infection. Of the 651 children with asymptomatic CMV infection, 48 (7.4%) developed sensorineural hearing loss (SNHL), compared to 85 (40.7%) of the children with symptomatic CMV infection. Children in both groups experienced latent effects consisting of delayed onset of loss, threshold fluctuations, and/or progressive loss of hearing. It can be concluded that congenital CMV infection is a leading cause of SNHL in children. The late onset and progression of loss necessitates continued monitoring of hearing sensitivity in this population. Abbreviations: ABR = auditory brainstem response, CMV = cytomegalovirus, OAEs = otoacoustic emissions, SNHL = sensorineural hearing loss
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Yazdani Khan, Mehboob, Ahmed Hasan Ashfaq, Saeed Ahmed, and Faisal Bashir. "SENSORINEURAL HEARING LOSS IN ADULTS;." Professional Medical Journal 24, no. 10 (2017): 1572–78. http://dx.doi.org/10.29309/tpmj/2017.24.10.711.
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Objectives: The objective of the study was to determine the etiology of SNHLin young adults between 18-45 years of age. Study design: Prospective study. Place andduration: The study was conducted at Benazir Bhutto Hospital, Rawalpindi from Jan 2012-13. Patients and methods: Patients presenting with hearing loss/ear blockage and additionalsymptoms were selected. Psychiatric problems were excluded from study. Patient’s problemwas analyzed through a protocol consisting of history, clinical examination, lab investigations,radiology and audiology. Results: The results of 25 patients were as follows: The age rangedfrom 18-45 years with marked preponderance of patients in 31-45 years age group amounting to60% of the total cases.18-20 years groups were least affected. The incidence of SNHL graduallyincreased in older age groups. There were more female patients 56% of the total as comparedto males, which were 44%. Bilateral SNHL was more 72% with compared to unilateral losswhich was 28%. The mode of onset was insidious in 72% cases while sudden loss was 28%.The duration of symptoms ranged between 3 days to 15 years. While fluctuation of hearing losswas observed in one case (4%). The nature of problem ranged from mild to severe. Associatedsymptoms were present in different percentages. The hearing loss ranged from 10-80 decibel.Trauma was the major cause 28% followed by infections in 16% with various causes in variouspercentages. Conclusion: The trauma in the form of surgery, blast injury and occupationalnoise is the major cause of SNHL in adults ranging between 18-45 years of age. Males are moreaffected because of trauma than the females and younger groups more than older groups.
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Alhamadani, Anmar Abdullah Jassim, Ghassan Mohammad Ahmed Alrawy, Ahmed Saadallah Ahmed Alhankawi, and Samet Almoula. "Sensorineural Hearing Loss in Diabetes Mellitus." Kufa Medical Journal 19, no. 1 (2023): 18–24. http://dx.doi.org/10.36330/kmj.v19i1.11076.
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Background: Sensorineural hearing loss are common neurological deficit, and diabetes mellitus is a common cause for these problems. Hearing impairment affects the quality of life of diabetic patients. Many researchers found hearing impairment in diabetic patients because diabetes mellitus can cause sensorineural hearing loss (SNHL) because of neuropathy and microvascular complications of diabetes mellitus. Aim of the study: The study aims to sensorineural hearing loss in diabetic patients compared with non-diabetic control. Patients and methods: A prospective case control study is performed during the period between Jan 2018 and May 2019. This case series study included 100 known cases of diabetes mellitus, their ages were between 20-60 years, treated at Al-wafaa center, which is specialized center for treatment and follow up of diabetic patients, and Al-Jumhory Teaching Hospital in Mosul. The control group included 100 individuals who did not have any diabetes mellitus or any of the exclusion criteria mentioned in the study. Results: It has been found that sensorineural hearing loss (SNHL) was more common in diabetic patients group than controls group, 21% versus 8%. The prevalence of (SNHL) was more in male 31.7% than female diabetic patients 13.5%. Hearing threshold in diabetic patients was higher than that in control group. The hearing loss in diabetic patients is slowly progressive and directly related to the duration of diabetes. Conclusions: Sensorineural hearing loss has been found to be more common in diabetic patients than in control group, and the hearing loss in diabetic patients is slowly progressive. The hearing threshold in diabetic patients had a direct correlation with the duration of disease.
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Warrick, P. D., P. Wardrop, and D. W. Sim. "Sensorineural hearing loss in MELAS syndrome." Journal of Laryngology & Otology 111, no. 3 (1997): 279–81. http://dx.doi.org/10.1017/s0022215100137089.
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AbstractA case of sensorineural hearing loss (SNHL) in MELAS syndrome, a variety of mitochondrial cytopathy, is presented. Mitochondrial cytopathies have gone almost unreported in the otolaryngology literature, despite evidence from a recent review that about 60 per cent of such patients suffer from SNHL (Gold and Rapin, 1994). The same review revealed that only one of 117 case reports in the period 1984–1993 contained an audiogram (Swift and Singh, 1988), and none presented sequential audiograms. However, audiometry has since been published on 23 members of a family with a mitochondrial point mutation causing only sensorineural hearing loss with no other symptoms (Vernham et al., 1994). We present a case of mitochondrial cytopathy three years after diagnosis with two sequential audiograms.
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Barbee, Christi, Jeffrey Danhauer, Anna Jilla, Suzanne Kimball, Katie Seever, and Carole Johnson. "Toward the Future of Early Intervention for Adult Hearing Loss." Seminars in Hearing 39, no. 02 (2018): 221–26. http://dx.doi.org/10.1055/s-0038-1641745.
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AbstractThis issue of Seminars in Hearing has focused on the early intervention of adult sensorineural hearing loss (SNHL). Contributions to this monograph have taken a contemporary issues approach to the prevention, diagnosis, and treatment of mild SNHL. This article looks toward the future and discusses clinical and research implications for the early intervention of adult SNHL.
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Mangalwaniya, Pratibha, and Sudhakar Vaidya. "Comparison of Sensorineural Hearing Loss in all Age Groups in the Year 2020 (COVID-19), 2021 and 2022: A Retrospective Study." Central India Journal of Medical Research 3, no. 02 (2024): 15–18. http://dx.doi.org/10.58999/cijmr.v3i02.165.
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Background: Hearing loss can be categorized into two types: Conductive and sensorineural. Sensorineural hearing loss, which becomes more prevalent with age, is the most common type and accounts for the majority of all hearing loss cases. This study aims to compare the prevalence of sensorineural hearing loss across all age groups in the years 2020 (during COVID-19), 2021, and 2022.Methods: The study was conducted in the Department of Otorhinolaryngology at R. D. Gardi Medical College in Ujjain (M.P.). A total of 901 patients with audiologically confirmed sensorineural hearing loss (SNHL) were included and evaluated in this study.Results: The patients’ ages ranged from 1 to 90 years, with a mean age of 54.13 years. The highest number of patients (30.52%) were in the 61 to 70 age group.In our study, we exclusively examined and reported 901 cases of sensorineural hearing loss, out of which total patients in 2020, 2021, and 2022 were 118 (13.09%), 336 (37.29%), and 447 (49.61%), respectively. A total of 78 (8.65%) cases were unilateral and 823 (91.34%) cases were bilateral. Male:Female ratios in 2020, 2021, and 2022 were 3.53:1, 1.60:1, and 2.31:1, respectively.Possible reasons for the reduction of sensorineural hearing loss during COVID-19 lockdown -1. Nearly all the services, factories, social gatherings and events were suspended during this phase.2. During the lockdown, there was a notable decrease in noise levels. Before the COVID-19 lockdown, average noise levels varied between 44.85 and 79.57 dB across different areas. However, during the lockdown, these levels dropped to between 38.55 and 57.79 dB.3. During the lockdown period, road traffic noise was notably reduced compared to the noise levels observed before and after the lockdown.4. In 2020, the outpatient department (OPD) was open only for emergency cases in March, April, and May, resulting in no diagnoses of sensorineural hearing loss (SNHL) during these three months. Additionally, even after the OPD resumed normal operations, the number of patients seeking treatment was notably lower compared to 2021 and 2022.Conclusion: Most patients with sensorineural hearing loss (SNHL) in this study were male, with an average age of 54.13 years. In 2020 (COVID-19), a total of 118 patients were affected with SNHL as compared to 336 and 447 patients in the years 2021 & 2022, respectively. Affected patients with SNHL in 2020 are less as compared to 2021 & 2022, as per the study.
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Sultana, K. J. Najma, and Rathi.S. "Sensorineural Hearing Loss and its Management through Ayurveda – A Case Study." International Research Journal of Ayurveda & Yoga 05, no. 09 (2022): 57–61. http://dx.doi.org/10.47223/irjay.2022.5910.
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Hearing is one of the primary modes of communication. Hearing loss is one of the most common sensory deficit and it comprises a broad spectrum of clinical presentations. Impairment of hearing occurs when there is inability for sounds to be transmitted through or interpreted by our brain. Disorders of internal ear and auditory nerve will lead to sensorineural hearing loss (SNHL). The management of the SNHL is conventionally with rehabilitation with hearing aids and cochlear implants, and the option for pharmacologically treating the hearing impairment is limited. Hence there is need to lookback to our classical methods as told by our Acharyasfor treating SNHL. In Ayurveda, hearing loss can be correlated to badhirya,wherein many therapeutic procedures, formulations have been told by our acharyas for the successful management of badhirya. So in the present case an attempt is made to treat a case of SNHL through ayurvedatreatment strategy
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Sen, Jayashree, Bitan Sen, Nikhil Akoijam Singh, Nitin Rajendra Alaspurkar, and Soumya Matturu. "Anesthetic Management in Pediatric Cochlear Implant." Journal of Datta Meghe Institute of Medical Sciences University 18, no. 3 (2023): 493–96. http://dx.doi.org/10.4103/jdmimsu.jdmimsu_517_22.
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Hearing loss can be conductive or sensorineural in nature. Sensorineural hearing loss (SNHL) affects the spiraling organ cochlea of the inner ear, which transforms the sound vibration into a neural signal or transmits it to the auditory part of the brain. Mild-to-severe SNHL, although can be rehabilitated successfully using hearing aids in extreme SNHL, hearing aids merely make the sound louder, distorted, and amplified where the clarity may be not enough for proper understanding to develop speech. Hence, in such cases, the best option for hearing and learning proper speech is a Cochlear implant (CI). Patients with irreversible hearing loss and deaf-mutism, a cochlear implant is an acceptable therapeutic option undertaken under general anesthesia and the hallmark of a successful anesthetic procedure is to provide a bloodless field during surgery.
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Ding, Shun, Yixuan Liu, Tingting Duan, et al. "Mendelian Randomization Reveals: Triglycerides and Sensorineural Hearing Loss." Bioengineering 11, no. 5 (2024): 438. http://dx.doi.org/10.3390/bioengineering11050438.
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Background: Sensorineural hearing loss (SNHL) is a multifactorial disorder with potential links to various physiological systems, including the cardiovascular system via blood lipid levels such as triglycerides (TG). This study investigates the causal relationship between TG levels and SNHL using Mendelian randomization (MR), which offers a method to reduce confounding and reverse causality by using genetic variants as instrumental variables. Methods: Utilizing publicly available genome-wide association study (GWAS) data, we performed a two-sample MR analysis. The initial analysis unveiled a causal relationship between TG (GWAS ID: ebi-a-GCST90018975) and SNHL (GWAS ID: finn b-H8_HL_SEN-NAS). Subsequent analysis validated this through MR with a larger sample size for TG (GWAS ID: ieu-b-111) and SNHL. To conduct the MR analysis, we utilized several methods including inverse-variance weighted (IVW), MR Egger, weighted median, and weighted mode. We also employed Cochrane’s Q test to identify any heterogeneity in the MR results. To detect horizontal pleiotropy, we conducted the MR-Egger intercept test and MR pleiotropy residual sum and outliers (MR-PRESSO) test. We performed a leave-one-out analysis to assess the sensitivity of this association. Finally, a meta-analysis of the MR results was undertaken. Results: Our study found a significant positive correlation between TG and SNHL, with OR values of 1.14 (95% CI: 1.07–1.23, p < 0.001) in the IVW analysis and 1.09 (95% CI: 1.03–1.16, p < 0.006) in the replicate analysis. We also found no evidence of horizontal pleiotropy or heterogeneity between the genetic variants (p > 0.05), and a leave-one-out test confirmed the stability and robustness of this association. The meta-analysis combining the initial and replicate analyses showed a significant causal effect with OR values of 1.11 (95% CI: 1.06–1.16, p = 0.01). Conclusion: These findings indicate TG as a risk factor for SNHL, suggesting potential pathways for prevention and intervention in populations at risk. This conclusion underscores the importance of managing TG levels as a strategy to mitigate the risk of developing SNHL.
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Jiang, Fan, Hannah Kuper, Tess Bright, and Wen-Zhe Qin. "Etiology of Childhood Bilateral Sensorineural Hearing Loss in Shandong Province, China." American Journal of Audiology 29, no. 2 (2020): 236–43. http://dx.doi.org/10.1044/2020_aja-19-00029.
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Objectives The purpose of this study is to ascertain the etiology of bilateral sensorineural hearing loss (SNHL) in children aged ≤ 18 years living in Shandong province. Method Data were taken from a cross-sectional study, which was conducted between 2015 and 2017. The study included children aged ≤ 18 years, recruited from special schools for children with hearing loss and from hearing rehabilitation centers in Shandong province of China. Children were screened for bilateral SNHL through audiological testing. Clinical examination, genetic testing, and structured interviews were conducted for those children who were identified as having hearing loss to identify the potential cause. Results The etiology of bilateral SNHL in our sample was genetic in 874 (39.3%), acquired in 650 (29.3%), and unknown in 697 (31.4%) children. Among children with acquired SNHL, the cause was maternal viral infection in 75 (11.5%); perinatal factors in 238 (36.6%); meningitis, measles, and mumps in 146 (22.5%); and ototoxic exposure in 117 (18%) children. Among the children with genetic SNHL, only 44 (4.9%) were identified as having syndromic hearing loss, and the remainder (95.1%) were classified as nonsyndromic hearing loss. Conclusion The findings indicated that nearly 30% of bilateral SNHL in Shandong province could be preventable through immunization, early prenatal diagnosis, proper treatment of infections, and avoidance of prescription of ototoxic drugs. This finding emphasizes the need for programs aimed at improving the health services at primary and secondary levels of health care, which will in turn prevent childhood hearing loss.
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Maruyama, Ayako, Yoshihiro Noguchi, Taku Ito, Kenji Narushima, and Ken Kitamura. "Sensorineural Hearing Loss Associated with a Factitious Disorder." Ear, Nose & Throat Journal 94, no. 12 (2015): E7—E10. http://dx.doi.org/10.1177/0145561320963438.
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Factitious disorders are characterized by intentionally abnormal physical and/or psychological behavior, and affected patients often make up their symptoms and clinical histories. The most serious and chronic type of factitious disorder is Munchausen syndrome. We report the case of a 24-year-old woman with a 2-year history of sensorineural hearing loss (SNHL) who later confessed to feigning her hearing loss. She was eventually diagnosed with a factitious disorder. During those 2 years, she was able to induce her SNHL by exposing herself to excessive noise or high doses of aspirin. To the best of our knowledge, this is the first report describing an association between a factitious disorder and SNHL.
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Sharma, Ankur, James M. Leaf, Saumya Thomas, et al. "Sensorineural hearing loss after neonatal meningitis: a single-centre retrospective study." BMJ Paediatrics Open 6, no. 1 (2022): e001601. http://dx.doi.org/10.1136/bmjpo-2022-001601.
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Babies in intensive care are at higher risk for meningitis and sensorineural hearing loss (SNHL). We reviewed the rate of SNHL among definite cases of bacterial/fungal meningitis in our neonatal intensive care unit over a 16-year period (2006–2021). We identified 16 confirmed meningitis cases among 16 070 admissions: 8 of 10 surviving infants with available diagnostic audiology had normal/satisfactory hearing while 2 of 10 had SNHL. Both infants with permanent hearing loss had been born extremely preterm and received potentially ototoxic antimicrobials. Larger studies are needed to clarify whether SNHL occurs mainly due to meningitis itself or to its antimicrobial drug treatment.
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Papadakis, Chariton E., Jiannis K. Hajiioannou, Dionysios E. Kyrmizakis, and John G. Bizakis. "Bilateral sudden sensorineural hearing loss caused by Charcot-Marie-Tooth disease." Journal of Laryngology & Otology 117, no. 5 (2003): 399–401. http://dx.doi.org/10.1258/002221503321626465.
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Charcot-Marie-Tooth (CMT) disease or hereditary motor and sensory neuropathy (HMSN) is a relatively common neurological syndrome, which has seldom been associated with hearing dysfunction, particularly sudden sensorineural hearing loss (SNHL). Families with autosomal dominant, autosomal recessive and X-linked forms of inheritance have been described.Sudden sensorineural hearing loss is a frustrating and frightening condition, especially if the hearing loss is bilateral. Regarding the site of the lesion, the evidence from the literature on HMSN suggests that either the VIIIth nerve or central auditory pathways are primarily involved in patients with hearing loss.We report the first case in the English literature of a patient with Charcot-Marie-Tooth type II disease presenting bilateral SNHL in the course of his disease. The patient was hospitalized for 15 days, and undergoing treatment without any audiological improvement. Detailed clinical, audiological and laboratory examination was performed.The aetiology and prognostic indicators of bilateral SNHL are discussed, as well as, the incidence of hearing loss in CMT patients.
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Welling, D. Bradley, Michael E. Glasscock, Charles I. Woods, and Ronald C. Sheffey. "Unilateral Sensorineural Hearing Loss Rehabilitation." Otolaryngology–Head and Neck Surgery 105, no. 6 (1991): 771–78. http://dx.doi.org/10.1177/019459989110500601.
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The Audiant Bone Conductor has been heralded as an aid for use in conductive hearing loss; however, its possible use in unilateral sensorineural hearing loss (SNHL) has also been proposed. Between July 1987 and July 1989, profound unilateral sensorineural hearing loss has been rehabilitated In 43 patients using the Xomed Audiant Bone Conductor. Patients who were willing to participate in this clinical trial and who were felt to be good contralateral routing of signals (CROS) aid candidates were selected preoperatively. Audiometric followup, selection criteria, patient satisfaction, and complications are discussed.
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Walton, Joseph P., and Karen Hendricks-Munoz. "Profile and Stability of Sensorineural Hearing Loss in Persistent Pulmonary Hypertension of the Newborn." Journal of Speech, Language, and Hearing Research 34, no. 6 (1991): 1362–70. http://dx.doi.org/10.1044/jshr.3406.1362.
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The purpose of this study was to examine the incidence, profile, and stability of sensorineural hearing loss (SNHL) in infants diagnosed with persistent pulmonary hypertension of the newborn (PPHN). Over a five-year period, 19 of 51 infants (37%) with PPHN were diagnosed with SNHL: 16 with bilateral and 3 with unilateral impairment. This incidence of SNHL is approximately 25 times greater than observed in graduates of our intensive care nursery. The profile of SNHL in the group of 19 children was typically downward sloping. However, there was considerable variation with respect to degree of loss. In addition, progressive SNHL was identified in 5 children whose hearing worsened an average of 55 dB at 2 to 4 kHz. On retrospective analysis, the perinatal variables associated with PPHN were comparable between hearing-impaired and normal-hearing infants. In contrast, the two groups were significantly different when treatment variables, such as the duration of mechanical ventilation or amikacin, were compared. Children with SNHL were treated for longer durations as compared to normal-hearing infants. Children with SNHL were subdivided into two groups, mild and severe, based on degree of loss and treatment variables, and compared again to the normal-hearing group. Two findings emerged from this analysis. First, the duration of hyperventilation was now the only variable significantly different between children with mild SNHL and children with normal hearing. Second, comparison of the mild with the severe SNHL groups showed that the duration of hyperventilation was similar. The pathophysiology and underlying mechanisms resulting in SNHL in PPHN survivors are discussed.
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Sameer Karmacharya, Ashish Dhakal, and Santosh Kumar Sah. "Prevalence of sensorineural hearing loss in patients with Diabetes Mellitus." Janaki Medical College Journal of Medical Science 12, no. 03 (2024): 46–51. https://doi.org/10.3126/jmcjms.v12i03.73965.
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Background & Objectives: Various kinds of auditory involvement are reported in diabetic subjects. One of them is that of gradual onset of bilateral sensorineural deafness, involving mainly higher frequencies in elderly patients. This study was aimed to access the prevalence of sensorineural hearing loss (SNHL) in a patient with Diabetes Mellitus and its relation to age, sex, duration of DM, and control of DM. Results: Diabetic patients had insidious onset, gradually progressive, bilaterally symmetrical SNHL. SNHL is prevalent in 72% of type 2 diabetes patients compared to 18% of controls. It is correlated with the increasing age and duration of diabetes. Poor control of diabetes showed an increased prevalence of SNHL compared to good control of diabetes. Conclusion: There was an increased prevalence of SNHL in type 2 diabetes patients and it is more evident in patients with long duration of diabetes and more pronounced in patients with poor diabetic control.
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Dahl, Christine, Iska Moxon-Emre, Vijay Ramaswamy, et al. "Neurocognitive outcome in children with sensorineural hearing loss after treatment of malignant embryonal brain tumors." Journal of Clinical Oncology 35, no. 15_suppl (2017): 2029. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.2029.
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2029 Background: Neurological side effects associated with childhood brain tumors and their treatments contribute to long term neurocognitive morbidity. The aims of this study were to identify the incidence of sensorineural hearing loss (SNHL) in a large sample of children treated for malignant brain tumors, and to evaluate the potential relationship between SNHL and intellectual functioning following the completion of treatment. Methods: We conducted a prospective follow-up study at a single center with review of 119 patients treated for embryonal brain tumors at the Hospital for Sick Children, between 1996-2015, to analyze the impact of significant SNHL (Chang > 2b) on intellectual function. Hearing was assessed post-treatment (median age: 13.5y (+4.5)) and the median age for neurocognitive testing was 12.8y (+ 4.1). The median interval from time of diagnosis was 5.8y (+ 3.7). Results: Severe SNHL was identified in half the patients (50.4%, n = 60/119). We identified a subset of patients (n = 61) who had assessments of intellectual function. In this cohort, intellectual function was significantly poorer in the group with severe SNHL, even after controlling for the effect of craniospinal radiation (severe SNHL 22.4 Gy + 13.3, no or mild hearing loss 20.4 Gy +12.8) and boost dose and volume. Children experiencing severe SNHL had lower overall IQ (severe SNHL 72.4 + 16.6; no/mild hearing loss 92.0 + 20.5) p < 0.001 and in significantly lower verbal comprehension (severe SNHL 78.7 + 15.9; no/mild hearing loss 94.7 + 13.8) p < 0.001, and working memory (severe SNHL 78.2+ 17.6; no/mild hearing loss 94.8 + 16.4) p < 0.001, scores. Conclusions: Hearing loss is a much more significant complication in children with embryonal brain tumors than previously estimated. We show the profound impact of hearing loss on intellectual deficit in children. Namely, patients with severe SNHL have difficulty using and understanding verbal language, and they have a reduced ability to concentrate and manipulate information in short-term memory. Our results have implications on future trial designs and follow-up of children treated for embryonal brain tumors.
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Huang, Xiaoqin, Yu Jia, and Lidong Jiao. "Sensorineural Hearing Loss as the Prominent Symptom in Meningeal Carcinomatosis." Current Oncology 28, no. 5 (2021): 3240–50. http://dx.doi.org/10.3390/curroncol28050281.
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Sensorineural hearing loss (SNHL) has been reported rarely in patients with meningeal carcinomatosis (MC). We summarized the clinical data of eight MC patients with SNHL and 35 patients reported from publications. In the eight patients with SNHL, the medium onset age was 48 (range from 37 to 66) years and six (75%) were male. Seven (87.5%) suffered from headaches as the initial symptom, and they experienced SNHL during the first two months after the occurrence of headaches (0.5 to 2 months, average 1.5 months). The audiogram configuration was flat in three patients (37.5%) and showed total deafness in five patients (62.5%). The damage of cranial nerves VI (abducens) was observed in six patients (75%), and four patients (50%) had cranial nerves VII (facial) injury during the disease course. The percentage of damage of cranial nerves was higher than the patients without SNHL (VIth, 75.0% vs. 13.3%, p = 0.002 and VIIth 50.0% vs. 6.7%, p = 0.012). Four (50%) patients suffered from lung adenocarcinoma as primary tumor, two (25%) experienced stomach adenocarcinoma, one had colon cancer, and one patient was unknown. The symptom of SNHL improved after individualized therapy in four patients (focal radiotherapy and chemotherapy for three patients and whole brain radiotherapy for one patient), but all passed away from 2 to 11 months after diagnosis. Total deafness and flat hearing loss in audiogram were the common types of SNHL resulting from MC. MC patients with SNHL were more likely to suffer from the damage of other cranial nerves, especially to cranial nerves VI and VII. Treatment might improve SNHL, but not improve the case fatality rate.
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Lakhwinder Singh, Ashu, and Manoj Kumar. "Ayurvedic management of Sensorineural Hearing Loss (Badhirya) - A Case Study." Journal of Ayurveda and Integrated Medical Sciences 9, no. 4 (2024): 287–90. http://dx.doi.org/10.21760/jaims.9.4.47.
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The inner ear is the main culprit of sensorineural hearing loss (SNHL), which is a specific type of hearing loss. Peripheral and Central SNHL (auditory pathway or cortex) can be distinguished. It might be congenital or acquired. Congenital: resulting from prenatal or perinatal conditions or from defects of the inner ear. About 90% of reported cases of hearing loss are related to it. There is currently no suggested course of treatment for it. Hearing loss is associated with Badhirya (hearing loss) in Ayurveda, and our Acharyas have prescribed numerous therapeutic techniques and formulations for the effective treatment of Badhirya (hearing loss). This case study demonstrates the efficacy of Ayurvedic treatment in improving the hearing capacity of a 42-year-old male patient who has had moderate to severe SNHL for two years. He was made to undergo both Ayurvedic procedures and medications. The names of the Ayurvedic procedures adopted are Nasya (nasal drops) with Shirbala Taila (101 Avrti), Karnapoorana with Bilwa Taila for 7 days, Sarivadi Vati, Dashmoola Arishta, and Ashavagandha Arishta internally for 45 days. The intervention resulted in a good improvement in hearing.
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Dr., Aysha Jamil Hafiz Zia Farooq Bhatti Dr Musarrat Fatima. "INSIDIOUS SENSORINEURAL HEARING LOSS IN CHRONIC SUPPURATIVE OTITIS MEDIA." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 03 (2019): 6044–47. https://doi.org/10.5281/zenodo.2601935.
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<strong><em>Background: </em></strong><em>Sensorineural hearing damage might remain one of consequence of long-lasting suppurative otitis mass media. </em> <strong><em>Objective</em></strong><em>: The objective of our research was to assess connotation of long-lasting suppurative otitis mass media through sensorineural range damage also to discover out whether sickness length had somewhat impression on hearing. </em> <strong><em>Methodology: </em></strong><em>The current research was a short-term research led at Lahore General Hospital. Diagrams of altogether patients who experienced operation for long-lasting suppurative otitis mass media from April 2014 to March 2018 remained studied. 160 patients in total of 570 encountered our presence standards also remained comprised in our research. The contralateral ear remained engaged as modification. Past record in addition audiograms remained studied from persevering diagrams for period of illness also indication of SNHL at 3 speech incidences ((510, 1000, in addition 2010 Hz). The information remained arrived also examined by SPSS version 20. </em> <strong><em>Results</em></strong><em>: Of 160 patients, 48 (30.2%) had SNHL. In the set of patients through epithelial illness(cholesteatoma) 17 in total of 47 patients had SNHL while in set of patients through mucosal illness (previously recognized as tub tympanic kind) 33 in total of 112 patients had SNHL. This hearing damage originate to remain deteriorating through period of illness in together sets (p=0.001).</em> <strong><em>Conclusion</em></strong><em>: The substantial connotation of SNHL remained originate by CSOM in addition illness period. Primary medical conduct would remain existing in order to stop irreparable SNHL.</em> <strong><em>Key Words: </em></strong><em>Otitis Media, Hearing Damage, Long-lasting Suppurative Otitis Media, Sensorineural.</em>
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Markova, Tatiana, Natalia Alekseeva, Maria Lalayants, et al. "Audiological Evidence of Frequent Hereditary Mild, Moderate and Moderate-to-Severe Hearing Loss." Journal of Personalized Medicine 12, no. 11 (2022): 1843. http://dx.doi.org/10.3390/jpm12111843.
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Congenital and early onset bilateral sensorineural hearing loss (SNHL) is mainly caused by mutations in numerous genes. The introduction of universal newborn hearing screening (UNHS) has increased the number of infants with mild, moderate, and moderate-to-severe sensorineural hearing loss (SNHL) detected in the first year of life. We aimed to evaluate the audiological features in patients with mild, moderate, and moderate-to-severe SNHL according to genotype. Audiological and genetic data were analyzed for 251 patients and their relatives with congenital bilateral mild, moderate, and moderate-to-severe SNHL. Hearing loss severity, audiogram profile, interaural symmetry, and dynamics of hearing thresholds were analyzed. In this case, 165 patients had GJB2 gene mutations, 30 patients were identified with STRC mutations, and 16 patients had pathogenic or likely pathogenic USH2A mutations. The presence of at least one GJB2 non-truncating variant in genotype led to less severe hearing impairment. The flat and gently sloping audiogram profiles were mostly revealed in all groups. The follow-up revealed the stability of hearing thresholds. GJB2, STRC, and USH2A pathogenic variants were detected in most patients in our cohort and were congenital in most cases.
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Gadag, Raveendra P., Puneeth S. Nayak, and Tejaswini J. "Clinical Asssessment of Sensorineural Hearing Loss among Diabetes Mellitus Patients." Bengal Journal of Otolaryngology and Head Neck Surgery 28, no. 2 (2020): 112–19. http://dx.doi.org/10.47210/bjohns.2020.v28i2.297.
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Background: Hearing impairment is known to hamper the quality of life among patients, especially among diabetics due to the association of neuropathy with diabetes. However, the prevalence and degree of the SNHL depends upon different factors, such as age, gender, disease duration of DM, family history and glycemic status of the patients. Therefore, this study aimed to assess the association of SNHL with DM duration and familial DM and gender preponderance among SNHL–DM patients.
 Methods: Total 140 patients with DM were assessed for hearing impairment using Rinne, Weber and Absolute Bone Conduction Tests along with pure tone audiometry. Patients’ glycaemic status was determined by estimating fasting blood glucose (FBG) and post prandial blood glucose (PPBG) levels. Independent t-test, chi-square, ANOVA and Pearson’s correlation tests along with linear regression model were used to find association and correlation using R software.
 Results: Out of 140 patients, 60 were suffering from SNHL and majority were suffering from bilateral minimal hearing loss. SNHL was significantly associated with family history, age, duration of DM, FBG and PPBG levels were(Pvalues:1.79E08, 4.41E-06 and 0.02), however, significant correlated with duration of DM, FBS and PPBG level (r value:0.14–0.41).Furthermore, significant SNHL at 500 and 8000Hz was observed in the present study (Pvalue:0.002).
 Conclusion: A conclusive proof was drawn that family history of DM serve as a valuable variable in assessing the SNHL among DM patients.
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Wu, W., and K. Å. Thuomas. "MR Imaging of 495 Consecutive Cases with Sensorineural Hearing Loss." Acta Radiologica 36, no. 4-6 (1995): 603–9. http://dx.doi.org/10.1177/028418519503600460.
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Purpose: To examine patients with sensorineural hearing loss (SNHL) with MR. Material and Methods: 495 consecutive patients with SNHL and 120 age-matched healthy controls were examined. Spin-echo (SE) and fast spin-echo (FSE) images were used with 1.5 T equipment. Results: An intracranial abnormality was found in 211 (42.6%) of the patients with 95 (19.2%) along the acoustic pathway. Eleven of the 95 patients had sensory hearing loss while 84 had neural hearing loss with the retrocochlear auditory pathway affected by lesions. In 62 of the 84 patients, the internal acoustic canal and cerebellopontine angle were involved. Twenty-two patients had intra-axial lesions. The controls had no pathologic changes along the auditory pathway. Conclusion: MR imaging in a patient with SNHL must cover the entire acoustic pathway from the cochlea to the superior temporal gyrus, and all the components of the auditory pathway should be scrutinized. The FSE-technique can be used to detect the lesions causing SNHL. FSE-sequences can replace SE-sequences.
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Ravi, Abinaya, Rock Britto Dharmaraj, Neethu George, Nishok Vijayakumar, Naveena Singaravel, and Nivetha Ravichandran. "Sensorineural Hearing Loss in Chronic Kidney Disease Patients - A Major Concern." Journal of Evolution of Medical and Dental Sciences 10, no. 38 (2021): 3454–56. http://dx.doi.org/10.14260/jemds/2021/699.
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Chronic kidney disease (CKD) is becoming a major health concern due to its increasing incidence among adults. There are few studies that suggest the possible relation between hearing loss and chronic kidney disease. So far only a small number of large population - based studies have assessed the relation between CKD and hearing loss. The global prevalence of CKD was 9.1 % (697.5 million cases) in 2017. The age and sex wise global prevalence of CKD was higher in women (9.5 %) than in men (7.3 %). In India, prevalence of sensorineural hearing loss (SNHL) is around 28 % to 77 % among CKD patients. Studies found that the incidence was 77 % for mild to very mild hearing loss and the incidence was 46 % for moderate to severe hearing loss. Various theories behind SNHL in CKD patients are structural similarity between ear and kidney, increased blood viscosity because of hypertension and finally electrolyte imbalance which are all thought to play a role in development of SNHL in CKD patients. Major risk factors for SNHL in CKD patients are duration of CKD, hypertension, diabetes mellitus, serum urea and creatinine levels, electrolyte imbalance, packed cell volume (PCV), ototoxic drugs. CKD being a long-term illness and majority of cases of SNHL in CKD patients are permanent, it has a great negative impact on the patient’s quality of life adding to the disability burden.
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Safdar, Rabia Saleem, M. Faisal Mehar, Madiha Naz, Afsheen Asghar Khan, Nusrat Buzdar, and Tooba Aleem. "Frequency of sensorineural hearing loss in children with bacterial meningitis." Professional Medical Journal 27, no. 12 (2020): 2729–33. http://dx.doi.org/10.29309/tpmj/2020.27.12.4672.
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Objectives: To determine the frequency of sensorineural hearing loss (SNHL) in children with bacterial meningitis. Study Design: Cross Sectional study. Setting: Department of Paediatric Medicine Nishtar Hospital, Multan. Period: October 2019 to March 2020. Material & Methods: The study was conducted after permission from ethical committee. A total of 151 patients admitted with bacterial meningitis were enrolled. Apart from the presenting complaints, necessary information like the age and gender were noted. Examination of the child was done to assess the condition of child. Brainstem evoked response audiometry (BERA) test was performed before discharge of the patient from the hospital. The outcome variable that is SNHL in bacterial meningitis assessed by BERA test was noted in a specifically designed Performa. Results: Out of total of 151 patients, males were 83 (55%) while females 68 (45%). Overall mean age was 11.85+6.12 months. SNHL was found in 26 (17.2%) children. There was no significant effect of age or gender on the frequencies of SNHL. Conclusion: SNHL is a frequently encountered complication in our population of children with bacterial meningitis. SNHL should be carefully sought out and properly diagnosed in all the patients presenting with bacterial meningitis.
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Aytekin, Gökhan, Fatih Çölkesen, Eray Yıldız, Mitat Arıcıgil, and Şevket Arslan. "Hearing Assessment in Adult Patients with Common Variable Immunodeficiency." Asthma Allergy Immunology 19, no. 1 (2021): 38–45. http://dx.doi.org/10.21911/aai.600.
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ABSTRACT Objective: Common Variable Immunodeficiency (CVID) is a primary antibody disorder characterized by impaired B cell differentiation. Patients commonly present with acute and chronic sinusitis as well as otitis media, which may lead to hearing loss. Materials and Methods: Thirty-three CVID patients (20 male /13 female) with a mean age of 35 years (range 19-65 years) and 33 healthy individuals as a control group were included. Results: Among CVID patients, 17 (51.5%) had conductive hearing loss (CHL) , being unilateral in 4 (12.1%) and bilateral in 13 (39.4%). Unilateral and bilateral sensorineural hearing loss (SNHL) were detected in 2 (6.1%) and 5 (15.2%) respectively. CD4/CD8 cell ratio was significantly lower while CD8+ T lymphocyte ratio was significantly higher in those with CHL than in those without it (p=0.045 and p=0.009). Elevated CD8+ T cell ratio was an independent risk factor for CHL (p=0.015). Patients with SNHL were significantly older than those without it (p=0.040). CD16-56+ cell count was significantly lower in those with SNHL (p=0.031). Conclusion: CVID patients have an increased occurrence of CHL and SNHL, regardless of the cause. They provide evidence for the notion that these two types of hearing loss are not unrelated, immune dysregulation also plays a role in the process, and SNHL is not independent of CHL. Keywords: Common variable immune deficiency, conductive hearing loss, sensorineural hearing loss
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Purnami, Nyilo, Cintya Dipta, and Mahrus Ahmad Rahman. "Characteristics of infants and young children with sensorineural hearing loss in Dr. Soetomo Hospital." Oto Rhino Laryngologica Indonesiana 48, no. 1 (2018): 11. http://dx.doi.org/10.32637/orli.v48i1.251.
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Background: Hearing loss is one of the congenital abnormalities frequently found in children, which is followed by delayed speech and language development. The majority of cases have unknown causes of hearing loss resulting in late diagnosis. Newborn Hearing Screening Program (NHSP) recommended Otoacoustic Emissions (OAE) and Brainstem Evoked Response Audiometry (BERA) as detection of hearing loss in infants and children. Objective: To obtain the prevalence and description of sensorineural hearing loss in infants and children. Method: A retrospective descriptive study of infants underwent OAE and BERA between 2011-2013 at Dr Soetomo Hospital. The degree of hearing loss was according to the International Standard Organization (ISO). Result: A total number of 552 infant and children were examined, and 377 (68%) were detected with sensorineural hearing loss (SNHL). This group of SNHL consisted of 199 males (52.79%) and 178 females (47.21%). The largest age group was 12 to 36 months, revealed 237 patients (62.86%) with SNHL. The majority degree of hearing loss was profound hearing loss in 329 patients (87.27%). The risk factors of SNHL mostly were not found, in 310 patients (82.23%). The majority number of SNHL was bilateral, in 357 patients (94.69%). Conclusion: SNHL was found in majority of infant and children in the Audiology Clinic of Dr.Soetomo Hospital. The hearing loss found were mostly profound and bilateral, with unknown risk factors, which might contribute to speech and language developmental delay. This is relevance with the Universal NHSP recommendation that early detection should be implemented to all newborn. ABSTRAK Latar belakang: Gangguan pendengaran adalah salah satu kelainan kongenital yang sering ditemukan, dan berpengaruh pada perkembangan bicara dan bahasa anak. Sebagian besar gangguan pendengaran tidak jelas ada faktor risikonya, sehingga tidak segera terdeteksi. Bila tidak dilakukan deteksi dini, akan menyebabkan keterlambatan diagnosis dan intervensi. Telah direkomendasikan oleh Newborn Hearing Screening Program (NHSP) pemeriksaan Otoacoustic Emissions (OAE) dan Brainstem Evoked Rresponse Audiometry (BERA) sebagai alat deteksi dini gangguan pendengaran pada bayi dan anak. Tujuan: Mendapatkan prevalensi dan deskripsi gangguan pendengaran sensorineural pada bayi dan anak. Metode: Penelitian deskriptif retrospektif dengan mengumpulkan data subjek periode 2011- 2013 di Rumah Sakit Dr.Soetomo. Pemeriksaan OAE menggunakan Distortion Product Otoacoustic Emissions. Pemeriksaan BERA berdasarkan International Standard Organization (ISO). Hasil: Terdapat sebanyak 377 pasien (68%) dengan gangguan pendengaran sensorineural dari total 552 bayi dan anak. Pada kelompok umur 12 sampai 36 bulan didapati gangguan pendengaran sensorineural tertinggi sebanyak 237 (62,86%) pasien. Sebagian besar pasien laki-laki sebanyak 199 (52,79%). Mayoritas pasien mengalami gangguan pendengaraan derajat sangat berat sebanyak 329 (87,287%) dari total 377 penderita. Mayoritas faktor risiko dari gangguan pendengaran yang tidak diketahui sebanyak 310 kasus (82,23%), dan mayoritas penderita mengalami gangguan pendengaran sensorineural bilateral sebanyak 357 (94,69%). Kesimpulan: gangguan pendengaran sensorineural ditemukan terbanyak pada bayi dan anak di Klinik Audiologi RSUD Dr. Soetomo. Derajat keparahan terbanyak adalah profound, dan ditemukan terbanyak bilateral. Faktor risiko yang tidak diketahui terbanyak ditemukan, dan bisa merupakan faktor yang berpengaruh pada kejadian lambat bicara dan berbahasa. Temuan ini sesuai dengan rekomendasi program skrining pendengaran yang seharusnya diterapkan pada semua bayi baru lahir.
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Boboshko, M. Yu, and E. V. Zhilinskaya. "Speech intelligibility in patients of different ages with chronic sensorineural hearing loss." Russian Otorhinolaryngology 20, no. 4 (2021): 8–14. http://dx.doi.org/10.18692/1810-4800-2021-4-8-14.
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Deterioration in speech intelligibility, the most common complaint of people with hearing loss, leads to social isolation and dramatically reduces the quality of life. The correction of peripheral hearing loss by hearing aid fitting does not always solve this problem in patients with chronic sensorineural hearing loss (SNHL). That is why in the process of audiological examination of patients with complaints of hearing loss, it is necessary to include methods of speech audiometry, which make it possible to comprehensively assess the functioning of the auditory system. The aim of the study: assessment of speech intelligibility in patients of different ages with SNHL. 94 people from 20 to 74 years of age were examined: 54 patients with SNHL (14 young and 40 elderly) and 40 people with normal hearing thresholds (20 young and 20 elderly). Besides the standard audiological examination, speech audiometry testing was conducted: evaluation of monosyllabic words intelligibility in quiet, binaural rapidly alternating speech test, dichotic digits test, Russian matrix sentence test (RuMatrix). Results: Speech intelligibility in elderly patients with SNHL was shown to be significantly worse than in young patients with a similar degree of hearing loss. The RuMatrix test in noise was proved to be the most sensitive test for comprehensive evaluation of the hearing system functioning.
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Klishova, E. A., L. E. Golovanova, and I. G. Andreeva. "The spatial hearing disability measured by the Spatial Hearing Questionnaire in clinically normal-hearing and in mild or moderate sensorineural hearing loss persons." Sensornye sistemy 38, no. 4 (2024): 49–59. https://doi.org/10.31857/s0235009224040059.
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The spatial hearing in patients with mild and moderate symmetrical chronic sensorineural hearing loss (SNHL) was studied using the Russian-language version of the Spatial hearing questionnaire (SHQ). 141 patients aged 47 to 82 years were examined. The comparative analysis was performed in the groups of age-related normal hearing, mild SNHL, moderate SNHL. A significant deterioration in spatial perception was shown, revealed by the results of the survey in both groups with SNHL, and the mild and moderate hearing loss groups significantly differed in some indicators. The deterioration of spatial perception revealed by the analysis of the subscales of the questionnaire and the quantitative estimates of spatial and temporal resolution obtained earlier with mild and moderate degrees SNHL were in good agreement. With moderate SNHL, the scores of all four subscales of the questionnaire were significantly reduced. In clinical practice, this questionnaire can be used as a screening method for assessing spatial hearing in patients with SNHL.
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Neelamkavi, Niya Joseph. "A PROSPECTIVE STUDY TO ASSESS THE OTOPROTECTIVE ROLE OF ANTIOXIDANT MULTIVITAMIN SUPPLEMENTATION IN SENSORINEURAL HEARING LOSS." UP STATE JOURNAL OF OTOLARYNGOLOGY AND HEAD AND NECK SURGERY 11, no. 1 (2023): 31–36. http://dx.doi.org/10.36611//upjohns/volume11/issue1/5.
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BACKGROUND In the general practice of an otolaryngologist, a significant number of patients present with sensorineural hearing loss(SNHL). Vascular compromise and oxidative stress contribute to the development of acquired hearing loss. Our research was formulated to confront the dilemma faced in offering anefficacious therapy to patients with SNHL. METHODS This prospective study was attempted to evaluate the therapeutic effect of antioxidant vitamins (A, C, and E) in SNHL in adult patients. Pre-treatment audiogram served as the baseline. PTA was repeated for all frequencies after antioxidant supplementation at the end of 1 year. Hearing gain was determined relative to each patient's baseline PTA values. Treatment success was based on improvement in PTA values. RESULTS In our study, there was a marginal improvement in the mean PTA values from baseline to postantioxidant treatment values. Though there was no significant gain in hearing among our study population, the further hearing deterioration was believed to be arrested or slowed after supplementation with antioxidants. CONCLUSION Our study suggests the existence of a salient otoprotective role oforal combination of vitamins A, C and E against SNHL. Keywords Hearing impairment; Sensorineural hearing loss; Pure tone audiometry; Vitamins; Antioxidants.
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Trupti, Savariya, and D. Prajapati Arpit. "Role of Platelet Rich Plasma in Sensory Neuronal Hearing Loss." International Journal of Pharmaceutical and Clinical Research 15, no. 10 (2023): 759–64. https://doi.org/10.5281/zenodo.11266530.
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<strong>Introduction: </strong>Platelet-Rich Plasma (PRP) emerges as a promising solution for sensory neuronal hearing loss. PRP’s regenerative potential, rooted in its growth factors, offers hope for restoring damaged sensory neurons and improving auditory function. This autologous approach minimizes the risk of adverse reactions, making PRP a safe option for patients. Our study delves into the use of activated PRP in the treatment of Sensorineural Hearing Loss (SNHL), assessing its impact on hearing restoration and quality of life, potentially providing a novel therapeutic avenue for this challenging condition. <strong>Material and Methods: </strong>In this 12-month prospective study at a tertiary care medical college, 55 eligible participants aged 1 to 45 years with Sensorineural Hearing Loss (SNHL) were enrolled. Fresh PRP was prepared and administered via intratympanic injections over three consecutive weeks. A follow-up at 6 months post-treatment assessed efficacy using Pure Tone Audiometry. Data analysis utilized the Chi-squared test for evaluating the impact of the PRP intervention. <strong>Results:</strong> In this study of 55 patients with idiopathic Sensorineural Hearing Loss (SNHL), results showed a relatively equal gender distribution (53% male, 47% female) across various age groups. The majority of patients exhibited decreased hearing, with additional symptoms reported in varying percentages. Bilateral involvement was common, and hearing loss severity ranged from mild to profound. Patients with mild hearing loss showed the highest rate of complete recovery (55%), while severe cases had a 5% chance of no recovery. Duration of SNHL and the subsequent recovery levels revealed a strong association, with shorter duration correlating with better recovery. Notably, transient dizziness (35%) and injection pain (58%) were common, but increased tinnitus was not reported as a complication following intratympanic Platelet-Rich Plasma (PRP) injections. <strong>Conclusion:</strong> Our study suggests that PRP shows promise in the management of Sensorineural Hearing Loss, with potential benefits in terms of efficacy and safety. Further research is warranted to validate and explore the mechanisms underlying these findings.
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Bhaumik, Shah. "Significance of Blood Tests in Diagnosing Idiopathic Unilateral Sensorineural Hearing Loss." International Journal of Pharmaceutical and Clinical Research 16, no. 10 (2024): 239–44. https://doi.org/10.5281/zenodo.14032667.
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Idiopathic sensorineural hearing loss accounts for the majority of cases. As a result, the outcome is determined by variables related to the type of disease and its management. These may come on suddenly or gradually. Many research are conducted to assess the correlation in abrupt diversity; however, there is still insufficient data to support causality. Studies on increasing variety and its effects are scarce. A prospective study was conducted on forty individuals with idiopathic unilateral SNHL in an effort to determine the parameters linked to the prognosis or severity of the disease. A strong correlation was discovered between distribution of random blood sugar and post therapy improvement in patients. There was no discernible correlation between the severity of progressive SNHL and any blood parameter, nor between other blood parameters and treatment outcome in abrupt SNHL. In unilateral ISSNHL, elevated blood sugar may have a detrimental impact on treatment success. Scientific research on “Unilateral Idiopathic Progressive Sensorineural Hearing Loss” shows little evidence of a connection or link with the illness’s etiology.
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Sakuma, Naoko, Hideaki Moteki, Hela Azaiez, et al. "Novel PTPRQ Mutations Identified in Three Congenital Hearing Loss Patients With Various Types of Hearing Loss." Annals of Otology, Rhinology & Laryngology 124, no. 1_suppl (2015): 184S—192S. http://dx.doi.org/10.1177/0003489415575041.
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Objectives: We present 3 patients with congenital sensorineural hearing loss (SNHL) caused by novel PTPRQ mutations, including clinical manifestations and phenotypic features. Methods: Two hundred twenty (220) Japanese subjects with SNHL from unrelated and nonconsanguineous families were enrolled in the study. Targeted genomic enrichment with massively parallel DNA sequencing of all known nonsyndromic hearing loss genes was performed to identify the genetic cause of hearing loss. Results: Four novel causative PTPRQ mutations were identified in 3 cases. Case 1 had progressive profound SNHL with a homozygous nonsense mutation. Case 2 had nonprogressive profound SNHL with a compound heterozygous mutation (nonsense and missense mutation). Case 3 had nonprogressive moderate SNHL with a compound heterozygous mutation (missense and splice site mutation). Caloric test and vestibular evoked myogenic potential (VEMP) test showed vestibular dysfunction in Case 1. Conclusion: Hearing loss levels and progression among the present cases were varied, and there seem to be no obvious correlations between genotypes and the phenotypic features of their hearing loss. The PTPRQ mutations appeared to be responsible for vestibular dysfunction.
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Elbashir, Khalid Elsir, Celine Richard, Tomas Bryndziar, et al. "Sensorineural Hearing Loss in Children with Sickle Cell Disease: A Series of Four Cases." Blood 144, Supplement 1 (2024): 5316. https://doi.org/10.1182/blood-2024-208939.
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Background The World Health Organization defines hearing loss as hearing thresholds of 20 dB or more in one or both ears. There is a paucity of literature on hearing impairment in individuals with sickle cell disease (SCD). Vaso-occlusion caused by sickled erythrocytes resulting in hypoxia of the organ of Corti and cochlear damage is hypothesized to cause hearing impairment in SCD. (Abdelmahmuod et al., 2020; Rissatto-Lago, 2022) Sensorineural hearing loss (SNHL) and conductive hearing loss (CHL) prevalence in the general population in the United States is estimated to be 11.6%, with both ears being equally affected. (Rein et al., 2024) SNHL accounts for most cases of hearing loss in SCD, and its prevalence in SCD is greater than in the general population. In pediatric patients with SCD, the SNHL prevalence ranges from 3.8% to 28.8%. (Lago et al., 2018) Furthermore, a French study focusing on pediatric patients with SCD reported that even children with normal hearing were found to harbor auditory processing disorders and subclinical audiology issues. (Bois et al., 2019) SCD-related hearing loss may be underdiagnosed in this patient population, as periodic audiology screening is recommended only for those on iron chelation therapy. Method This is a case series describing 4 pediatric patients (&lt;18 years of age) with SCD not on chelation therapy, who were diagnosed with SNHL based on clinical symptoms and confirmed by a diagnostic audiogram. Demographic, laboratory, imaging, healthcare utilization, and medication use data for these patients were extracted from the Sickle Cell Clinical Research and Intervention Program (SCCRIP; NCT02098863) database, and clinical characteristics, audiological data, and outcomes for these patients were extracted from medical records by retrospective chart review. Results All 4 patients with SNHL had normal newborn hearing screenings and were screened for hearing loss based on symptoms and/or clinical suspicion. Other risk factors for SNHL, such as history of pneumococcal infections, noise-induced hearing loss, trauma, malignancies, genetic disorders, and exposure to ototoxic medications were ruled out. The age at diagnosis of hearing loss ranged from 5 to 16 years. Three patients had HbSS, and one had HbSC genotype. All 4 patients were on hydroxyurea therapy, with fetal hemoglobin levels ranging from 8% to 40%. Three of the 4 patients had moderate to severe hearing loss at the time of the audiology diagnosis and were prescribed hearing aids. High healthcare utilization was noted in these individuals, with the average annual number of emergency department visits and hospital admissions before the SNHL diagnosis ranging from 1 to 4 and 2 to 6, respectively. Three patients had sickle retinopathy, and 3 patients had obstructive sleep apnea. Conclusion In this case series, we highlight 4 patients with SCD with SNHL without an identified etiology, suggesting that the underlying SCD pathophysiology may be contributing to the development of SNHL in this patient population, and may present early in life. In this case series, all 4 patients were not on chelation therapy and not receiving screening audiograms, hence were diagnosed only when their symptoms were severe (moderate-severe deafness). Given the high prevalence of SNHL and subclinical hearing impairment in SCD reported in the literature, early and periodic routine audiology screening should be considered for all patients with SCD. Prospective studies of larger cohorts should be conducted to ascertain the role of SCD as an independent risk factor for SNHL, identify other risk factors in this population, and evaluate the role of SCD disease-modifying therapies in preventing SNHL in this patient population.
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Seidullayeva, A., D. Bayesheva, B. Turdalina, et al. "Sensorineural hearing loss after bacterial meningitis in children residing in Nur-Sultan." Infekcionnye bolezni 18, no. 4 (2020): 189–94. http://dx.doi.org/10.20953/1729-9225-2020-4-189-194.
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Bacterial meningitis (BM) is a widespread health problem characterized by severe clinical manifestations and high incidence of neurological complications. BM remains one of the main causes of disability and mortality among young children all over the world. Hearing loss is one of neurological complications associated with BM. It accounts for up to 60%–90% of all cases of acquired sensorineural hearing loss (SNHL). Between 2015 and 2018, we performed screening for SNHL among children who had had BM. Seven out of 62 patients examined (11.3%) were found to have SNHL. BM was primarily caused by Streptococcus pneumoniae (n = 4) and Neisseria meningitidis (n = 3). Three out of 4 patients had grade 3–4 SNHL. Computed tomography revealed cochlear ossification in two children and cochlear fibrosis in one child (who had successful cochlear implantation later). For the rest of the patients, we recommended hearing aids. We also found that hearing loss usually develops after BM and does not affect patients with viral meningitis (caused by enteroviruses). We recommend that children with BM undergo regular screening for SNHL (every 3 days during treatment) using otoacoustic emission. These patients should be also examined by an audiologist after discharge from hospital and then every three months for a year. Key words: children, cochlear implantation, meningitis, sensorineural hearing loss, acquired deafness
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Chavadaki, Jyothi Anand, and Mohammed Nadeem Afroze Malli. "Prevalence of sensorineural hearing loss in type 2 diabetes mellitus." International Journal of Otorhinolaryngology and Head and Neck Surgery 5, no. 5 (2019): 1227. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20193860.
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<p class="abstract"><strong>Background:</strong> The association of sensorineural hearing loss (SNHL) in diabetes mellitus patients is known since decades, yet there is no clear consensus among previous studies, with respect to the prevalence of SNHL in type 2 diabetes patients and the effect of duration and control of diabetes on hearing acuity. Hence the objectives of this study are to find the prevalence of SNHL in type 2 diabetes patients and to find the effect of duration and control of diabetes on hearing loss.</p><p class="abstract"><strong>Methods:</strong> The present study was conducted on 86 type 2 diabetes patients attending Navodaya Medical College Hospital, Raichur and age and gender matched 86 non- diabetic controls in the age group of 30-65 years, selected based on inclusion and exclusion criteria. After detailed history taking and clinical examination, all subjects underwent FBS, PPBS estimation and HbA1c evaluation was done for diabetic patients. All underwent pure tone audiometry and the findings were recorded and analyzed. </p><p class="abstract"><strong>Results:</strong> Diabetes patients had insidious onset, gradually progressive, bilaterally symmetrical SNHL. SNHL is prevalent in 67.44% of type 2 diabetes patients compared to 23.26% of controls. It is aggravated with the increasing age and duration of diabetes. Poor control of diabetes showed increased prevalence of SNHL compared to good control of diabetes.</p><p align="left"><strong>Conclusions:</strong> There is increased prevalence of SNHL in type 2 diabetes patients and it is more evident in patients with long duration of diabetes and more pronounced in patients with poor diabetic control.</p>
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Lahiri, Asish Kumar, Anandita Gupta, Rakesh Vohra, Shalabh Sharma, and Satinder Singh. "Cochlear Otosclerosis: An Undiagnosed Cause of Progressive Sensorineural Hearing Loss." Bengal Journal of Otolaryngology and Head Neck Surgery 28, no. 2 (2020): 127–37. http://dx.doi.org/10.47210/bjohns.2020.v28i2.329.
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Introduction
 Otosclerosis presents as conductive or mixed hearing loss depending upon the stage of the disease. Isolated sensorineural hearing loss though known to occur has been rarely reported. Pure cochlear otosclerosis presenting as sensorineural hearing loss should be considered as a differential diagnosis in young patients presenting with progressive hearing loss. The aim of this article is to note the prevalence of cochlear otosclerosis in young patients presenting with progressive sensorineural hearing loss. 
 Materials and Methods
 Retrospective chart analysis of 19 patients who presented with progressive SNHL with unknown etiology was done.
 Results
 Otosclerosis involving the pericochlear region was diagnosed in 27 ears which was identified by high resolution CT scan of temporal bone. In four ears, in addition, there was demineralization just anterior to oval window without clinical evidence of stapes fixation.
 Conclusion
 In young patients with progressive SNHL, high resolution CT scan of temporal bone should be done to identify progressive cochlear otosclerosis. Medical management should be initiated in these patients to halt the progression of disease.
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Fancello, Virginia, Giuseppe Fancello, Stavros Hatzopoulos, et al. "Sensorineural Hearing Loss Post-COVID-19 Infection: An Update." Audiology Research 12, no. 3 (2022): 307–15. http://dx.doi.org/10.3390/audiolres12030032.
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The course of COVID-19 infection may be complicated by a variety of neurological manifestations. Since the inner ear is vulnerable to viruses, sensorineural hearing loss (SNHL) has been reported to occur following the SARS-CoV-2 infection, often resulting in long-term morbidity and worsening the quality of life. The interest in how the virus affects the inner ear has gradually increased since the pandemic’s spread, but little is still known about the SNHL potentially caused by SARS-CoV-2. The aim of this paper is to evaluate the possible association between SNHL and COVID-19 infection, through a systematic literature review. Currently available data suggest that SARS-CoV-2 may hamper cochlear function; however, available reports are still limited. Large cohort and prospective studies are necessary to evaluate the long-term effects of this viral infection in the inner ear.
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Ye, Liting, Dong Lai, and Junhu Tai. "The association between anemia and sensorineural hearing loss: A review." Medicine 103, no. 44 (2024): e40326. http://dx.doi.org/10.1097/md.0000000000040326.
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Anemia affects a third of the world’s population and contributes to increased morbidity and mortality, decreased work productivity, and impaired neurological development. In recent years, many studies have found a possible association between anemia and sensorineural hearing loss (SNHL), especially in various types of nutritional deficiency and hemoglobin disorders anemia. Anemia may affect hearing through various mechanisms, including affecting microcirculation in the ear, causing tissue hypoxia in the ear, and through inflammatory and oxidative stress pathways. This review aims to comprehensively analyze the association between various types of anemia and SNHL, including possible biological mechanisms, clinical features, and treatment strategies, and clarify the importance of anemia treatment and management in preventing SNHL.
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Zhang, Yi, Hang Pei, and Bang-Jian He. "Additional comments on foot reflexology treatment for sensorineural hearing loss in infant." World Journal of Clinical Cases 12, no. 30 (2024): 6407–9. http://dx.doi.org/10.12998/wjcc.v12.i30.6407.
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Currently, treatment options for infant sensorineural hearing loss (SNHL) are limited. This article describes a novel case of SNHL in an infant successfully treated with foot reflexology, along with observed brain activity changes before and after treatment, as indicated by functional magnetic resonance imaging. Hence, this commentary discusses the case and our viewpoints regarding foot reflexology for treating SNHL.
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Siska Citra Amalia, Nyilo Purnami, Rosa Falerina, and Nugroho Suharsono. "Sudden sensorineural hearing loss in COVID-19 patient with hearing improvement." International Journal of Life Science Research Archive 4, no. 2 (2023): 063–67. http://dx.doi.org/10.53771/ijlsra.2023.4.2.0052.
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Introduction: Sudden Sensorineural Hearing Loss (SSNHL) is a newly revealed clinical manifestation in COVID-19 patients. This is because corona virus is thought to cause auditory neuropathy spectrum disorders, inflammation, hypoxia due to erythrocyte deoxygenation, ischemia due to vascular occlusion, and immunological reactions that induce cellular stress pathways in peripheral to central auditory organs. Case: A case of SSNHL in patient who were confirmed positive for PCR swab. A 66-year-old man with severe COVID-19, with hypertension and DM, had moderate right SNHL, left severe SNHL, when the PCR swab result was negative. Therapy received: methylcobalamin, gingkobiloba, HBOT, and the hearing was improved. Conclusion: SSNHL was obtained in COVID-19 patient.