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Relevant bibliographies by topics / Sensory receptors / Dissertations / Theses

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Dissertations / Theses on the topic 'Sensory receptors'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Piñón, Luzia Giraldez Pereira. "Neurotrophin switching in developing sensory neurons." Thesis, University of St Andrews, 1997. http://hdl.handle.net/10023/14774.

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The main aim of this project was to define the neurotrophin survival requirements of sensory neurons during the early stages of their development both in vivo and in vitro. The in vitro survival of neural crest-derived but not placode-derived cranial sensory neurons is promoted by several different neurotrophins early in their development. Neural crest-derived neurons subsequently lose responsiveness to all neurotrophins except NGF. Loss of responsiveness of neural crest-derived sensory neurons to BDNF and NT3 is associated with a marked shift in the dose responses of these neurons to higher n

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2

Overend, Tim. "The effect of frusemide on intrapulmonary sensory receptors." Thesis, Liverpool John Moores University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337788.

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3

Assis, Temilce Simoes de. "Characterisation of P2 receptors expressed in sensory neurones." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288723.

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4

Brumovsky, Pablo R. "Neuropeptides, sensory neurons and pain modulation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-442-2/.

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5

Hörnberg, Maria. "Effects of retinoic acid in the mouse olfactory sensory systems /." Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1371.

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6

Karchewski, Laurie Ann. "Neurotrophins and neurotrophin receptors in adult primary sensory neurons." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0034/NQ63884.pdf.

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7

Meira, Guilherme Louzada Silva. "Analíse da expressão do receptor olfativo M93 em sistemas heterólogos." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-31082016-115408/.

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O sistema olfatório de mamífero pode discriminar milhares de odores presentes no meio ambiente. Aproximadamente 1000 diferentes receptores olfatórios (ORs) são expressos no epitélio olfatório (OE) do nariz, Os ORs detectam os odores e transmitem os sinais resultantes para o bulbo olfatório (OB) no cérebro. Os ORs pertencem a super família dos receptores acoplados a proteína G (GPCR) e apresentam sete domínios transmembrânicos putativos. Por razões desconhecidas, os ORs são retidos no retículo endoplasmático quando expressos em linhagens de células de mamíferos heterólogas. Provavelmente, prote

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8

Jones, Christopher M. "Expression and folding studies of the ankyrin repeat domain of the capsaicin receptor." Click here for download, 2006. http://wwwlib.umi.com/cr/villanova/fullcit?p1432833.

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9

Johnson, Claire. "Sensory and chemical analysis of the bitter-sweet taste interaction." Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262530.

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10

Salazar, Eduardo 1962. "GABAᴀ Receptors in Rat Whisker Barrel Cortex: Effects of Sensory Deprivation". Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc279232/.

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The GABAergic system in adult sensory cortex is affected by sensory deprivation, but little is known about how this predominant inhibitory system is affected during ontogeny. The present study investigates developmental effects of whisker trimming on GABAa receptors in rat barrel cortex. Rats trimmed for 6 wk beginning at birth and adulthood showed similar decreases in [3H]muscimol binding in deprived relative to non-deprived barrels, suggesting absence of a critical period.

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11

Hashimoto, Sanae. "Search for receptor mediated processes in Amoeba proteus /." Connect to online version, 2006. http://ada.mtholyoke.edu/setr/websrc/pdfs/www/2006/142.pdf.

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12

Cselényi, Zsolt. "Development, validation and application of advanced neuroimaging analysis tools for in vivo neuroreceptor studies /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-261-6/.

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13

Verge, Valerie Mary Kathleen. "Properties of intact and injured sensory neurons with nerve growth factor receptors." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74557.

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The role of nerve growth factor (NGF), a neurotrophic molecule, and its high-affinity receptor in intact and injured adult rat lumbar sensory neurons was examined at a cellular level using quantitative receptor radioautography to localize the NGF high-affinity receptor-positive subpopulation, in conjunction with histochemistry on adjacent sections. The 40-50% of sensory neurons displaying NGF receptors were characterized. Virtually all neurons containing substance P or CGRP were NGF receptor-positive, but not those with somatostatin or thiamine monophosphatase activity. The ability of a neuron

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14

STANTCHEVA, KALINA KRASSIMIROVA. "A SUBPOPULATION OF ITCH RECEPTORS MARKED BY RET EXPRESSION." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/241111.

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Sensory neurons are a heterogeneous group of cells that are specialized to detect stimuli acting on the skin such as touch, temperature, pain and itch. A major challenge in the sensory biology field is to isolate and characterize specific functional subsets of neurons as an exhaustive knowledge of many of them is still lacking. In my PhD project I established a protocol to analyse and sort by Fluorescently Activated Cell Sorting (FACS) peripheral sensory neurons, in order to isolate specific subsets and further perform gene expression profiling. In particular I applied these techniques to Av

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15

Patullo, Blair. "Sensory biology of aquatic Australian crustaceans." Connect to thesis, 2010. http://repository.unimelb.edu.au/10187/8393.

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Sensory biology of animals is studied throughout the world for the insight it provides to understanding ecosystems and improving how we manage species. In this research, I designed experiments to investigate the sensory biology and behaviour of two Australian species of freshwater crayfish from the genus Cherax, the yabby (Cherax destructor) and redclaw crayfish (Cherax quadricarinatus). Experimental apparatus were constructed and tailored to test specific questions on physiology, tactile (touch) sensitivity, observation techniques, aggressive behaviour and responses to electrical fields. The

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16

Lau, Mark 1959. "Factors affecting the expression of acetylcholine receptors on rat sensory neurons in culture." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65516.

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17

Myers, Warren Kellen. "Pain and perspective| Compartmented co-culture to evaluate sensory neuron peripheral glutamate receptors." Thesis, Oklahoma State University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10191366.

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<p>The neurotransmitter L-Glutamate is the primary excitatory neurotransmitter of sensory neurons in the dorsal root ganglion (DRG). These neurons may also express ionotropic glutamate receptors, causing the potential for them to be directly excited by their own release of glutamate, from a neighboring neuron, or from other tissues. Glutamate is elevated in tissues after injury or inflammation, and iGluR signaling from the periphery has been shown to increase signaling in DRG neurons and contribute to the development of chronic pain. Targeting pharmacologic intervention of sensory neuron iG

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18

El-Nour, Husameldin. "Study of serotonin, innervation and sensory neuropeptides in allergic contact dermatitis /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-464-3/.

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19

Mwilaria, Esther K. "Psychophysical measures of detection & discrimination and effects of GABA blockade in the moth Manduca sexta." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5071.

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Thesis (M.S.)--West Virginia University, 2007.<br>Title from document title page. Document formatted into pages; contains vi, 53 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 50-51).

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20

Montelius, Andreas. "Role of transcription factors in sensory neuron specification /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-115-9/.

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21

Schmidt, Yvonne [Verfasser]. "Peripheral opioid receptors and inhibition of sensory neuron excitability following nerve injury / Yvonne Schmidt." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025510518/34.

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22

Kamaid, Toth Andres. "BMP4 regulation of sensory organ development in the chick inner ear." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7137.

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Bone morphogenetic proteins (BMPs) are diffusible molecules involved in a variety of cellular interactions during development. In particular, Bmp4 expression accompanies the development of the ear sensory organs during patterning and specification of sensory cell fates, and it has been shown to play a role in inner ear development and morphogenesis. However, there is no understanding of the cellular effects of BMP4 in prosensory progenitors, and about its role in the process of sensory fate specification. The present thesis project was aimed at exploring the effects of BMP-signaling on the dev

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23

Rieling, Janine Ann. "Sensory receptor neuron turnover in the olfactory epithelium of the snail, Achatina fulica : an autoradiographical study." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63382.

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24

Liu, Min. "Coexpression of recombinant P2X receptors and their relation to ATP gated channels in sensory neurons." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251671.

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25

Pal, Choudhuri Shreoshi. "Receptors for the detection of L-amino acids and IMP by mouse taste sensory cells." ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/473.

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The sense of taste is one of the most important factors in regulating ingestive decisions. This is central to a number of disease conditions including but not limited to obesity, diabetes, anorexia, hypertension, coronary artery diseases and malnutrition. The detection of the molecules eliciting taste qualities in food is mediated by the coordinated actions of distinct types of taste sensory cells (TSCs) housed in taste buds within specialized papillae throughout the oral cavity. Taste receptors in the taste sensory cells that detect food molecules are the key players in selecting dietary nutr

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26

Imaizumi, Kazuo. "Peripheral representation of sound frequency in cricket auditory system : beyond tonotopy." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36956.

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Crickets provide a useful model system to study how animals analyze sound frequency. While much is known about how sound frequency is represented by central neurons and in behavior, little is yet known about auditory receptor neurons. I investigated physiological and anatomical properties of auditory receptor fibers (ARFs) and functional organization of their axon terminals, using single-unit recording and staining techniques. Behavioral experiments suggest that crickets are sensitive to two broad frequency ranges, centered at 4--5 kHz for acoustic communication and at 25--50 kHz for predator

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27

Hayes, Heather Brant. "Biomechanics and electrophysiology of sensory regulation during locomotion in a novel in vitro spinal cord-hindlimb preparation." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42797.

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The purpose of this dissertation was to gain insight into spinal sensory regulation during locomotion. To this end, I developed a novel in vitro spinal cord-hindlimb preparation (SCHP) composed of the isolated in vitro neonatal rat spinal cord oriented dorsal-up with intact hindlimbs locomoting on a custom-built treadmill or instrumented force platforms. The SCHP combines the neural and pharmacological accessibility of classic in vitro spinal cord preparations with intact sensory feedback from physiological hindlimb movements. thereby expanding our ability to study spinal sensory function. I t

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28

Vick, Jonathan. "The Contribution of Purinergic P2X and P2Y Receptors to the Excitability of Mouse Vomeronasal Sensory Neurons." ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/283.

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Olfaction, the sense of smell, allows animals to perceive the multitude of volatile and nonvolatile molecules present in the environment. In many mammals, such as mice and rats, there are four unique chemosensory organs including the (1) main olfactory epithelium (MOE), (2) septal organ, (3) GrÃ¼neberg ganglion, and (4) vomeronasal organ (VNO). While the VNO detects some general volatile odorants, it is further specialized for the detection of behaviorally relevant nonvolatile odorants or pheromones. In rodents, the VNO is encased within a bony capsule and located at the base of the nasal cavi

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29

Batista, Daniel Rodrigo. "Estudo dos receptores purinérgicos em células gliais do glânglio da raiz dorsal." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-16032009-122053/.

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Receptores purinérgicos são expressos em neurônios e glia e, por certo, participam dos processos de sinalização entre estes células. Nos gânglios da raiz dorsal o soma dos neurônios sensoriais é envolto por uma camada de células satélites (CSt), que são células de glia, cuja função é desconhecida. Até o momento a natureza dos receptores purinérgicos presentes nas células satélites foi pouco investigada. No presente trabalho demonstra-se a presença dos receptores P2Y1, P2Y2 e/ou P2Y4 e P2Y6 nas CSt de gânglios da raiz dorsal de ratos recém-nascidos. A prova da existência dos receptores foi a el

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30

Impey, Danielle. "Assessment of Transcranial Direct Current Stimulation (tDCS) on MMN-Indexed Auditory Sensory Processing." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35576.

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Transcranial direct current stimulation (tDCS) is a non-invasive form of brain stimulation which uses a very weak constant current to temporarily excite or inhibit activity in the brain area of interest via electrodes placed on the scalp, depending on the polarity and strength of the current. Presently, tDCS is being used as a tool to investigate frontal cognition in healthy controls and to improve symptoms in neurological and psychiatric patients. Relatively little research has been conducted with respect to tDCS and the auditory cortex (AC). The primary aim of this thesis was to elucidate th

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31

Mora, García Natalia. "Analisis de la expresión y la función del gen beta-amyloid protein precursor like en relación a la vía de RasI en el disco imaginal de ojo de Drosophila melanogaster." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/104149.

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Drosophila es un modelo versátil para entender las bases genéticas de la señalización celular. En particular, el ojo compuesto de Drosophila proporciona un tejido ideal para estudiar los mecanismos de integración de señales que dirigen la formación de la red de neuronas fotorreceptoras. La vía de Ras/MAPK está involucrada en la determinación de todos los fotorreceptores, pero es particularmente necesaria para la especificación del fotorreceptor R7, ya que su ausencia determina la transformación del R7 en una célula no neural. De manera que durante el desarrollo del ojo, Ras media la decisión

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Conde, Silvia Margarida Vilares Santos. "Functional significance of adenosine in carotid body chemosensory activity in control and chronically hypoxic animals." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2007. http://hdl.handle.net/10362/5524.

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ABSTRACT: Carotid bodies (CB) are peripheral chemoreceptor organs sensing changes in arterial blood O2, CO2 and pH levels. Hypoxia and acidosis or hypercapnia activates CB chemoreceptor cells, which respond by releasing neurotransmitters in order to increase the action potential frequency in their sensory nerve, the carotid sinus nerve (CSN). CSN activity is integrated in the brainstem to induce a fan of cardiorespiratory reflex responses, aimed at normalising the altered blood gases. Exogenously applied adenosine (Ado) increases CSN chemosensory activity inducing hyperventilation through acti

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Carvalho, Viviane Fernandes de. "Avaliação da sensibilidade cutânea em pés de pacientes diabéticos através do Pressure Specified Sensory Device TM." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5158/tde-29052008-112413/.

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A neuropatia diabética causa diminuição ou perda da sensibilidade protetora do pé, tornando-o mais vulnerável ao trauma mecânico e térmico. A profilaxia das complicações neuropáticas tem início pela identificação da perda de sensibilidade e, portanto, do comprometimento neurológico. O Pressure Specified Sensory Device(TM) (PSSD) é um equipamento desenvolvido para quantificar o limiar de pressão, aplicada sobre a pele, necessária para que o paciente perceba o estímulo provocado por: um ponto estático, um ponto em movimento, dois pontos estáticos e dois pontos em movimento. Denominamos grupo est

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34

Wong, Jin Yan Hilary. "The octopaminergic modulatory circuitry of the Drosophila larval mushroom body calyx." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/285104.

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How are neuromodulatory networks organised to adapt sensory discrimination for different contexts? I hypothesised that neurons within a sensory circuit express different neuromodulatory receptors for differential modulation. Here I aimed to use the simple and genetically amenable Drosophila larval Mushroom Body (MB) calyx, a higher order processing area involved in learned odour discrimination, as a model to map octopamine (OA) neuromodulatory circuitry. I first identified olfactory projection neurons (PNs), a GABAergic feedback neuron and cholinergic extrinsic neurons as putative postsynaptic

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35

Souleymane, Diallo. "Coding of tsetse repellents by olfactory sensory neurons: towards the improvement and the development of novel tsetse repellents." University of Western Cape, 2021. http://hdl.handle.net/11394/8039.

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Philosophiae Doctor - PhD<br>Tsetse flies are the biological vectors of human and animal trypanosomiasis and hence representant medical and veterinary importance. The sense of smell plays a significant role in tsetse and its ecological interaction, such as finding blood meal source, resting, and larvicidal sites and for mating. Tsetse olfactory behaviour can be exploited for their management; however, olfactory studies in tsetse flies are still fragmentary. Here in my PhD thesis, using scanning electron microscopy, electrophysiology, behaviour, bioinformatics and molecular biology techniques,

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36

Stevanovic, Bettina. "The effect of learning on pitch and speech perception : influencing perception of Shepard tones and McGurk syllables using classical and operant conditioning principles." Thesis, View thesis, 2007. http://handle.uws.edu.au:8081/1959.7/33694.

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This thesis is concerned with describing and experimentally investigating the nature of perceptual learning. Ecological psychology defines perceptual learning as a process of educating attention to structural properties of stimuli (i.e., invariants) that specify meaning (i.e., affordances) to the perceiver. Although such definition comprehensively describes the questions of what humans learn to perceive, it does not address the question of how learning occurs. It is proposed in this thesis that the principles of classical and operant conditioning can be used to strengthen and expand the ecolog

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37

Colton, Craig K. "TRPV3 is a polymodal receptor." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164046830.

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Souleymane, Diallo. "Coding of tsetse repellents by olfactory sensory neurons: towards the improvement and the development of novel." University of the Western Cape, 2020. http://hdl.handle.net/11394/8236.

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Philosophiae Doctor - PhD<br>Tsetse flies are the biological vectors of human and animal trypanosomiasis and hence representant medical and veterinary importance. The sense of smell plays a significant role in tsetse and its ecological interaction, such as finding blood meal source, resting, and larvicidal sites and for mating. Tsetse olfactory behaviour can be exploited for their management; however, olfactory studies in tsetse flies are still fragmentary. Here in my PhD thesis, using scanning electron microscopy, electrophysiology, behaviour, bioinformatics and molecular biology techniques,

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39

Taguchi, Toru. "Altered Response to the Mechanical Stimulation of C-Fiber Sensory Receptors Recorded in Vitro from the Rat Exercised Muscle(RIEM Conference Ⅱ,2003)." Research Institute of Environmental Medicine, Nagoya University, 2003. http://hdl.handle.net/2237/7611.

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40

Cattaneo, Alberto Maria. "Unveiling sensory mechanisms for the control of two insect pests: from behaviour to molecular interactions." Doctoral thesis, country:IT, 2015. http://hdl.handle.net/10449/29924.

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Pest control strategies targeting insect olfaction represent a promising venue for control of tortricid insects (Lepidoptera: Tortricidae). Among tortricids, the grapevine moth Lobesia botrana (Denis and Schiffermüller) and the codling moth Cydia pomonella (L.) are serious pests for worldwide production of fruit crops. We employed several approaches to the olfactory system, from electrophysiological and behavioral studies in the grapevine moth, to bioinformatic and molecular studies of olfactory sensory proteins in the codling moth. At the receptor level, we studied both the Olfactory Receptor

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Stevanovic, Bettina. "The effect of learning on pitch and speech perception influencing perception of Shepard tones and McGurk syllables using classical and operant conditioning principles /." View thesis, 2007. http://handle.uws.edu.au:8081/1959.7/33694.

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Thesis (Ph.D.)--University of Western Sydney, 2007.<br>A thesis submitted to the University of Western Sydney, College of Arts, School of Psychology in fulfilment of the requirements for the degree of Doctor of Philosophy. Includes bibliography.

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Duncan, Robert Keith. "Finite-element analysis of inner ear hair bundles : a parameter study of bundle mechanics /." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-09292009-020226/.

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Gomes, Isa. "Effects of endocrine disruptors on Phallusia mammillata embryonic development." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS419/document.

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Le bisphénol A (BPA) est une molécule dérivée du plastique, considéré comme un perturbateur endocrinien (PE) pour sa capacité de liaison aux récepteurs nucléaires (RNs). Il est associé à des troubles neurodéveloppementaux, probablement en raison de la présence de certains RNs dans le cerveau des vertébrés. Les PEs peuvent également affecter les invertébrés marins, dont les ascidies, mais leur mode d'action reste inconnu. Mon projet de thèse a pour but d’étudier la toxicité du BPA sur le développement embryonnaire de l'ascidie Phallusia mammillata. Tout d’abord, j’ai évalué l’expression des RNs

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Lin, Chia-Hui. "The Effects of Growth Hormone in the Inner Ear of Zebrafish (Danio rerio) during Hair Cell Regeneration." TopSCHOLAR®, 2010. http://digitalcommons.wku.edu/theses/191.

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Although deafness is a universal problem, effective treatments have remained elusive. In order to develop potential treatments, an overall understanding of the cellular process of auditory hair cell regeneration, which occurs in fish but not mammals, must be established. A previous microarray analysis and qRT-PCR validation of noise-exposed zebrafish showed that growth hormone (GH) was significantly upregulated during the process of auditory hair cell regeneration. Thus, GH may play an important role during hair cell regeneration. However, cellular effects of exogenous GH in the zebrafish audi

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Chappell, Tyson. "The long-term teratogenic effect of prenatal alcohol exposure on the somatosensory and motor cortex of rats." View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/ABSTRACTS/2007-013-Chappell-index.htm.

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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2007.<br>Title from title page screen (viewed on February 29, 2008). Research advisor: Robert S. Waters, Ph.D. Document formatted into pages (xix, 179 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 152-178).

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Gomes, Isa. "Effects of endocrine disruptors on Phallusia mammillata embryonic development." Electronic Thesis or Diss., Sorbonne université, 2018. http://www.theses.fr/2018SORUS419.

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Le bisphénol A (BPA) est une molécule dérivée du plastique, considéré comme un perturbateur endocrinien (PE) pour sa capacité de liaison aux récepteurs nucléaires (RNs). Il est associé à des troubles neurodéveloppementaux, probablement en raison de la présence de certains RNs dans le cerveau des vertébrés. Les PEs peuvent également affecter les invertébrés marins, dont les ascidies, mais leur mode d'action reste inconnu. Mon projet de thèse a pour but d’étudier la toxicité du BPA sur le développement embryonnaire de l'ascidie Phallusia mammillata. Tout d’abord, j’ai évalué l’expression des RNs

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Kelleher, Jayne Hannah. "Isolation of sensory neurons in vitro and generation of a conditional inducible transgenic mouse line against nerve growth factor (NGF) receptors to investigate the role of NGF in pain." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/isolation-of-sensory-neurons-in-vitro-and-generation-of-a-conditional-inducible-transgenic-mouse-line-against-nerve-growth-factor-ngf-receptors-to-investigate-the-role-of-ngf-in-pain(1d0d15ee-7aec-4f07-a307-351c75de1050).html.

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Nerve growth factor (NGF) is a known factor in the development of persistent pain, a condition which affects approx. 20% of the UK population. Current therapeutics available for pain exhibit limited effectiveness and therefore better targeted and more effective therapeutics are essential. Clinical trials using anti-NGF have been successful in consistently alleviating pain of patients suffering from chronic pain however the main mechanism of action of NGF is unknown. The main aim of this PhD was to investigate the role for TrkA and p75 receptors for NGF in the development of persistent pain, sp

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Marchenkova, Anna. "A study of modulation of P2X3 and TRPV1 receptors by the B-type natriuretic peptide and novel synthetic compounds in trigeminal sensory neurons of wild type and migraine-model mice." Doctoral thesis, SISSA, 2015. http://hdl.handle.net/20.500.11767/4888.

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Background Trigeminal ganglion (TG) is a key player in processing noxious stimuli. Among many ligand-gated ion channels, trigeminal sensory neurons express on their membranes purinergic P2X3 receptors and capsaicin-sensitive transient receptor potential vanilloid 1 channels (TRPV1). These receptors are thought to be involved in pain transduction and pathophysiology of different pain syndromes, including migraine disorders. P2X3 and TRPV1 channels are continuously regulated by a variety of endogenous modulators, which, upregulating these receptors, can cause sensitization and promote developmen

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Coltro, Pedro Soler. "Avaliação da sensibilidade cutânea do retalho perfurante da artéria pudenda interna nas reconstruções perineais." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-01122014-152200/.

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INTRODUÇÃO: O tratamento das neoplasias malignas anorretais exige ressecções que podem levar ao surgimento de defeitos perineais extensos. Esses defeitos necessitam de reconstrução que deve ser realizada, preferencialmente, com retalhos. Dentre eles, destacamos o retalho perfurante da artéria pudenda interna, localizado no sulco glúteo, vascularizado por vasos perfurantes cutâneos da artéria pudenda interna, e inervado por ramos do nervo pudendo e do nervo cutâneo femoral posterior. Esse retalho apresenta diversas vantagens em comparação com os outros utilizados para reconstrução perineal, e o

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Bates, Ferdia. "Design and development of molecularly imprinted polymers and imprinted sensors." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/399170.

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Esta tesis se ha hecho principalmente para estudiar e investigar polímeros impresos (MIPs) con la intención de usarlos como sensores de larga vida. La línea de investigación de esta tesis es la dirigida a conseguir la integración de estas formaciones impresas dentro de una lengua electrónica (ET), que es la rama de especialización en la que se ha desarrollado principalmente este proyecto. Después de hacer una revisión de la literatura, que inicialmente se centraba en la aplicación de MIPs a un equipo electroquímico, un sensor voltamétrico impreso y un procedimiento sensitivo complementario, el

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