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Journal articles on the topic 'Septal alcohol ablation'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Petrova, Desislava P., Sotir T. Marchev, and Boyko D. Kuzmanov. "Alcohol Septal Ablation." Journal of Biomedical and Clinical Research 8, no. 2 (2015): 104–11. http://dx.doi.org/10.1515/jbcr-2015-0159.

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Summary Since 1994, alcohol septal ablation (ASA) has been used as a minimally invasive treatment of patients with hypertrophic obstructive cardiomyopathy, resistant to conservative medical therapy. This catheter-based intervention consists of injecting absolute alcohol in a septal perforator to induce infarction of the hypertrophied septum and thus diminish the left ventricle outflow tract obstruction. This reduction of the gradient is associated with reduction of symptoms and left ventricle remodeling. The procedure was improved after the introduction of myocardial contrast echocardiography

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2

Hsu, Jen-Te, Ju-Feng Hsiao, Jung-Jung Chang, Chang-Min Chung, Shih-Tai Chang, and Kuo-Li Pan. "Microvascular Permeability Changes Might Explain Cardiac Tamponade after Alcohol Septal Ablation for Hypertrophic Cardiomyopathy." Texas Heart Institute Journal 41, no. 2 (2014): 217–21. http://dx.doi.org/10.14503/thij-12-3118.

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Various sequelae of alcohol septal ablation for hypertrophic obstructive cardiomyopathy have been reported. Of note, some cases of cardiac tamponade after alcohol septal ablation cannot be well explained. We describe the case of a 78-year-old woman with hypertrophic obstructive cardiomyopathy in whom cardiac tamponade developed one hour after alcohol septal ablation, probably unrelated to mechanical trauma. At that time, we noted a substantial difference in the red blood cell-to-white blood cell ratio between the pericardial effusion (1,957.4) and the peripheral blood (728.3). In addition to p

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3

Quintana, Eduard, Pietro Bajona, María José Arguis, and Susanna Prat-González. "Septal myectomy after failed septal alcohol ablation." Annals of Cardiothoracic Surgery 6, no. 4 (2017): 394–401. http://dx.doi.org/10.21037/acs.2017.05.11.

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4

Maron, Barry J., and Rick A. Nishimura. "Surgical Septal Myectomy Versus Alcohol Septal Ablation." Circulation 130, no. 18 (2014): 1617–24. http://dx.doi.org/10.1161/circulationaha.114.011580.

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5

Talreja, Deepak R., Rick A. Nishimura, William D. Edwards, et al. "Alcohol septal ablation versus surgical septal myectomy." Journal of the American College of Cardiology 44, no. 12 (2004): 2329–32. http://dx.doi.org/10.1016/j.jacc.2004.09.036.

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6

Todurov, B. M., G. I. Kovtun, A. V. Khokhlov, et al. "The results of alcoholic septal ablation in the treatment of hypertrophic cardiomyopathy." Cardiac Surgery and Interventional Cardiology, no. 4 (December 2020): 44–49. http://dx.doi.org/10.31928/2305-3127-2020.4.4449.

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Hypertrophic obstructive cardiomyopathy іs a relatively common condition and one of the most common causes of sudden cardiac death in young age. One of the options for the surgical treatment of this pathology is septal myoectomy, which has been the gold standard for decades. However, despite this, surgical treatment is intended for young patients with a low risk of postoperative complications, while patients with concomitant diseases and a higher surgical risk require alternative treatment. Today, alcohol septal ablation is considered an effective, minimally invasive method for treating hypert

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7

Okutucu, Sercan, Kudret Aytemir, and Ali Oto. "Glue septal ablation: A promising alternative to alcohol septal ablation." JRSM Cardiovascular Disease 5 (March 7, 2016): 204800401663631. http://dx.doi.org/10.1177/2048004016636313.

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8

Heldman, Alan W., Katherine C. Wu, Theodore P. Abraham, and Duke E. Cameron. "Myectomy or Alcohol Septal Ablation." Journal of the American College of Cardiology 49, no. 3 (2007): 358–60. http://dx.doi.org/10.1016/j.jacc.2006.10.029.

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9

Geske, Jeffrey B., and Bernard J. Gersh. "Myectomy Versus Alcohol Septal Ablation." JACC: Cardiovascular Interventions 7, no. 11 (2014): 1235–36. http://dx.doi.org/10.1016/j.jcin.2014.05.022.

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10

Gold, Matthew, Josiah Bennett, Maaz Ahmed, et al. "OUTCOMES OF ALCOHOL SEPTAL ABLATION." Journal of the American College of Cardiology 83, no. 13 (2024): 731. http://dx.doi.org/10.1016/s0735-1097(24)02721-9.

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11

Cherif, Ehab, and Sami Ghazal. "Alcohol Septal Ablation after Suboptimal Surgical Septal Myomectomy." CASE 2, no. 5 (2018): 210–17. http://dx.doi.org/10.1016/j.case.2018.02.004.

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12

Nikolaeva, I. E., V. V. Plechev, A. M. Mukhametyanov, R. M. Biktashev, I. V. Buzaev, and G. A. Khalikova. "Contrast Enhanced Echocardiography-Controlled Alcohol Septal Ablation for Hypertrophic Cardiomyopathy with Left Ventricular Outflow Tract Obstruction." Creative surgery and oncology 9, no. 2 (2019): 132–37. http://dx.doi.org/10.24060/2076-3093-2019-9-2-132-137.

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In the SFHI (State Funded Healthcare Institution) Republic’s Centre for Cardiology the method of alcohol septal ablation has been introduced in 2015. The paper presents one case of a successful treatment of a patient with hypertrophic cardiomyopathy with left ventricular outflow tract obstruction treated with the use of the method of alcohol septal ablation under control of contrast enhanced echocardiography of the ablation area in the interventricular septum.

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13

Reza, AQM, Nighat Islam, SU Talukdar, et al. "Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy: A case Report." Cardiovascular Journal 15, no. 1 (2022): 95–99. http://dx.doi.org/10.3329/cardio.v15i1.61918.

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Alcohol septal ablation (ASA) has shown to be a safe and effective procedure for treatment of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) for more than 20 years with results similar to those of surgical myectomy. The first septal branch of the left anterior descending artery (LAD) is located and 96% alcohol is instilled to induce an artificial myocardial infarction and necrosis at the base of the hypertrophied septum. Now we present our first experience of a patient with HOCM with a very high left ventricular outflow tract gradient who had successful alcohol septal ablation. Car

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14

Sherrid, Mark V., Daniele Massera, and Daniel G. Swistel. "Surgical Septal Myectomy and Alcohol Ablation." Journal of the American College of Cardiology 79, no. 17 (2022): 1656–59. http://dx.doi.org/10.1016/j.jacc.2022.03.332.

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15

Sherrid, Mark V., Daniele Massera, and Daniel G. Swistel. "Surgical Septal Myectomy and Alcohol Ablation." Journal of the American College of Cardiology 79, no. 17 (2022): 1656–59. http://dx.doi.org/10.1016/j.jacc.2022.03.332.

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16

K. Galle, J. De Sutter, and K. Cornelis. "Alcohol septal ablation to overcome shock." Acta Cardiologica 65, no. 2 (2010): 249–51. http://dx.doi.org/10.2143/ac.65.2.2047061.

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17

Fifer, M. A., and U. Sigwart. "Hypertrophic obstructive cardiomyopathy: alcohol septal ablation." European Heart Journal 32, no. 9 (2011): 1059–64. http://dx.doi.org/10.1093/eurheartj/ehr013.

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18

Yoerger, Danita M., Michael H. Picard, Igor F. Palacios, Gus J. Vlahakes, and Michael A. Fifer. "Triphasic response to alcohol septal ablation." Journal of the American College of Cardiology 39 (March 2002): 157. http://dx.doi.org/10.1016/s0735-1097(02)80694-5.

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19

Bahl, Ajay. "Alcohol septal ablation – An evolving procedure." Indian Heart Journal 64, no. 6 (2012): 591–93. http://dx.doi.org/10.1016/j.ihj.2012.10.002.

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20

Boltwood, Chester M., Walter Chien, and Thomas Ports. "Ventricular Tachycardia Complicating Alcohol Septal Ablation." New England Journal of Medicine 351, no. 18 (2004): 1914–15. http://dx.doi.org/10.1056/nejm200410283511824.

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21

Honěk, Jakub, and Josef Veselka. "Intracardiac echocardiography-guided alcohol septal ablation." Cor et Vasa 56, no. 5 (2014): e411-e412. http://dx.doi.org/10.1016/j.crvasa.2013.08.003.

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22

Kuhn, Horst J. "The history of alcohol septal ablation." Cardiovascular Revascularization Medicine 11, no. 4 (2010): 260–61. http://dx.doi.org/10.1016/j.carrev.2009.11.003.

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23

Eleid, Mackram F., and Rick A. Nishimura. "Patient Selection for Alcohol Septal Ablation." JACC: Cardiovascular Interventions 9, no. 5 (2016): 470–71. http://dx.doi.org/10.1016/j.jcin.2015.12.263.

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24

Veselka, Josef, Morten Jensen, Max Liebregts, et al. "Alcohol septal ablation in patients with severe septal hypertrophy." Heart 106, no. 6 (2019): 462–66. http://dx.doi.org/10.1136/heartjnl-2019-315422.

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ObjectiveThe current guidelines suggest alcohol septal ablation (ASA) is less effective in hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular hypertrophy, despite acknowledging that systematic data are lacking. Therefore, we analysed patients in the Euro-ASA registry to test this statement.MethodsWe compared the short-term and long-term outcomes of patients with basal interventricular septum (IVS) thickness <30 mm Hg to those with ≥30 mm Hg treated using ASA in nine European centres.ResultsA total of 1519 patients (57±14 years, 49% women) with symptomatic H

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25

Fifer, Michael A. "Choice of Septal Reduction Therapies and Alcohol Septal Ablation." Cardiology Clinics 37, no. 1 (2019): 83–93. http://dx.doi.org/10.1016/j.ccl.2018.08.009.

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26

Gragnano, Felice, Francesco Pelliccia, Natale Guarnaccia, et al. "Alcohol Septal Ablation in Patients with Hypertrophic Obstructive Cardiomyopathy: A Contemporary Perspective." Journal of Clinical Medicine 12, no. 8 (2023): 2810. http://dx.doi.org/10.3390/jcm12082810.

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Alcohol septal ablation is a minimally invasive procedure for the treatment of left ventricular outflow tract (LVOT) obstruction in patients with hypertrophic obstructive cardiomyopathy (HOCM) who remain symptomatic despite optimal medical therapy. The procedure causes a controlled myocardial infarction of the basal portion of the interventricular septum by the injection of absolute alcohol with the aim of reducing LVOT obstruction and improving the patient’s hemodynamics and symptoms. Numerous observations have demonstrated the efficacy and safety of the procedure, making it a valid alternati

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27

Afanasyev, Alexander V., Alexander V. Bogachev-Prokophiev, Maxim G. Kashtanov, et al. "Myectomy versus alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy." Interactive CardioVascular and Thoracic Surgery 31, no. 2 (2020): 158–65. http://dx.doi.org/10.1093/icvts/ivaa075.

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Abstract OBJECTIVES There is very little evidence comparing the safety and efficacy of alcohol septal ablation versus septal myectomy for a septal reduction in patients with hypertrophic obstructive cardiomyopathy. This study aimed to compare the immediate and long-term outcomes of these procedures. METHODS Following propensity score matching, we retrospectively analysed outcomes in 105 patients who underwent myectomy and 105 who underwent septal ablation between 2011 and 2017 at 2 reference centres. RESULTS The mean age was 51.9 ± 14.3 and 52.2 ± 14.3 years in the myectomy and ablation groups

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28

Kelley, Brian, Michael Halista, Thelsa Weickert, John Vavalle, and Michael Yeung. "LAD Occlusion From Alcohol Reflux During Alcohol Septal Ablation." JACC: Case Reports 30, no. 3 (2025): 103103. https://doi.org/10.1016/j.jaccas.2024.103103.

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29

Koljaja-Batzner, Angelika, Barbara Pfeiffer, and Hubert Seggewiss. "Septal Collateralization to Right Coronary Artery in Alcohol Septal Ablation." JACC: Cardiovascular Interventions 11, no. 19 (2018): 2009–11. http://dx.doi.org/10.1016/j.jcin.2018.05.034.

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30

Knight, Charles, and Saidi Mohiddin. "Alcohol Septal Ablation for Obstructive Hypertrophic Cardiomyopathy." European Cardiology Review 3, no. 2 (2007): 88. http://dx.doi.org/10.15420/ecr.2007.0.2.88.

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31

Sorajja, Paul, Robert Fraser, Robert Steffen, and Kevin M. Harris. "Alcohol Septal Ablation for Obstructive Hypertrophic Cardiomyopathy." Interventional Cardiology Clinics 11, no. 3 (2022): 245–55. http://dx.doi.org/10.1016/j.iccl.2022.03.001.

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32

Kashtanov, M. G., S. D. Chernyshev, L. V. Kardapoltsev, S. V. Berdnikov, and E. M. Idov. "Three Achilles’ heels of alcohol septal ablation." Patologiya krovoobrashcheniya i kardiokhirurgiya 21, no. 3 (2017): 12. http://dx.doi.org/10.21688/1681-3472-2017-3-12-22.

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<p>This manuscript looks at basic limitations of alcohol septal ablation in obstructive hypertrophic cardiomyopathy. They include high-grade atrioventricular blockages, residual obstructions of the left ventricular outflow tract and the so-called proarrhythmic effects of alcohol septal ablation procedure. All these weaknesses are reviewed in the context of incidence, etiology, and prevention.</p><p>Received 25 February 2017. Accepted 10 April 2017.</p><p><strong>Funding:</strong> The study did not have sponsorship.</p><p><strong>Confl

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33

Spencer, William H., and Robert Roberts. "Alcohol Septal Ablation in Hypertrophic Obstructive Cardiomyopathy." Circulation 102, no. 6 (2000): 600–601. http://dx.doi.org/10.1161/01.cir.102.6.600.

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34

SEGGEWISS, HUBERT, LOTHAR FABER, and PEER ZIEMSSEN. "Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy." Cardiology in Review 7, no. 6 (1999): 316–23. http://dx.doi.org/10.1097/00045415-199911000-00009.

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35

ABBAS, AMR E., STACY D. BREWINGTON, SIMON R. DIXON, CINDY L. GRINES, and WILLIAM W. O'NEILL. "Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy." Journal of Interventional Cardiology 18, no. 3 (2005): 155–62. http://dx.doi.org/10.1111/j.1540-8183.2005.04107.x.

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36

Nielsen, Christopher D., Valerian Fernandes, and William H. Spencer. "Alcohol Septal Ablation for Obstructive Hypertrophic Cardiomyopathy." American Heart Hospital Journal 1, no. 1 (2003): 83–90. http://dx.doi.org/10.1111/j.1541-9215.2003.02091.x.

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37

Sitar, J., L. Groch, N. Penkov, L. Dimitrova, and R. Radoslavova. "Alcohol septal ablation for hypertrophic obstructive cardiomyopathy." Heart - Lung (Varna) 19, no. 1-2 (2013): 42. http://dx.doi.org/10.14748/hl.v19i1-2.3354.

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38

Knight, C. J. "Alcohol septal ablation for obstructive hypertrophic cardiomyopathy." Heart 92, no. 9 (2006): 1339–44. http://dx.doi.org/10.1136/hrt.2005.063677.

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39

Arias, Eduardo A., Marco Antonio Peña-Duque, and Marco Antonio Martínez-Ríos. "Bubble Contrast Echocardiography for Alcohol Septal Ablation." Revista Española de Cardiología (English Edition) 72, no. 5 (2019): 416. http://dx.doi.org/10.1016/j.rec.2018.04.016.

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40

Liebregts, Max, Pieter A. Vriesendorp, and Jurrien M. ten Berg. "Alcohol Septal Ablation for Obstructive Hypertrophic Cardiomyopathy." Journal of the American College of Cardiology 70, no. 4 (2017): 481–88. http://dx.doi.org/10.1016/j.jacc.2017.02.080.

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41

Sorajja, Paul. "Alcohol Septal Ablation for Obstructive Hypertrophic Cardiomyopathy." Journal of the American College of Cardiology 70, no. 4 (2017): 489–94. http://dx.doi.org/10.1016/j.jacc.2017.06.011.

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42

Parakh, Neeraj, and Balram Bhargava. "Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy." JACC: Cardiovascular Interventions 2, no. 1 (2009): 74. http://dx.doi.org/10.1016/j.jcin.2008.10.007.

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43

Maron, Barry J., and Rick A. Nishimura. "Revisiting Arrhythmic Risk After Alcohol Septal Ablation." JACC: Heart Failure 2, no. 6 (2014): 637–40. http://dx.doi.org/10.1016/j.jchf.2014.07.008.

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44

Masry, Hicham, and Jeffrey Breall. "Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy." Current Cardiology Reviews 4, no. 3 (2008): 193–97. http://dx.doi.org/10.2174/157340308785160561.

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45

Riis Hansen, P., and C. Hassager. "Septal alcohol ablation and Heyde's syndrome revisited." Journal of Internal Medicine 253, no. 4 (2003): 490–91. http://dx.doi.org/10.1046/j.1365-2796.2003.01127.x.

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46

Jai Bharat, B., Varun, C. N. Makhale, et al. "Alcohol septal ablation therapy for HOCM patients." Indian Heart Journal 67 (December 2015): S58. http://dx.doi.org/10.1016/j.ihj.2015.10.143.

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47

McKay, Joshua, and Sherif F. Nagueh. "Alcohol Septal Ablation to Reduce Heart Failure." Interventional Cardiology Clinics 6, no. 3 (2017): 445–52. http://dx.doi.org/10.1016/j.iccl.2017.03.012.

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48

Toutouzas, Konstantinos, Antonis Karanasos, Aris Anastasakis, et al. "Optimal branch selection in alcohol septal ablation." International Journal of Cardiology 147, no. 1 (2011): 143–44. http://dx.doi.org/10.1016/j.ijcard.2009.10.016.

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49

Ben-Dor, Itsik, Gabriel Maluenda, Zuyue Wang, et al. "Alcohol septal ablation in hypertrophic obstructive cardiomyopathy." Cardiovascular Revascularization Medicine 13, no. 1 (2012): 72–74. http://dx.doi.org/10.1016/j.carrev.2010.12.005.

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50

Joyal, Dominique, Dinesh Arab, Carol Chen-Johnston, and Ferdinand Leya. "Alcohol septal ablation after failed surgical myectomy." Catheterization and Cardiovascular Interventions 69, no. 7 (2007): 999–1002. http://dx.doi.org/10.1002/ccd.21165.

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