Relevant bibliographies by topics / Septic/mortality/therapy

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Septic/mortality/therapy'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Septic/mortality/therapy"

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Sudaryadi, Sudaryadi, Eddy Harijanto, and Indro Mulyono. "Comparison of Hydrocortisone with Combined Hydrocortisone, Ascorbic Acid, and Thiamine as an Adjuvant Therapy on Septic Shock Patients on Mortality: A Systematic Review and Meta-analysis." Open Access Macedonian Journal of Medical Sciences 11, F (2023): 171–79. http://dx.doi.org/10.3889/oamjms.2023.9952.

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BACKGROUND: Septic shock is still considered a global health problem because it is the main cause of morbidity and mortality in critical patients. Various clinical studies have proven that intravenous administration of high dose ascorbic acid and corticosteroid helps slow the inflammation cascade. These studies help lower the global sepsis and septic shock burden with cost-effective methods and minimum side effects. We systematically reviewed the comparison between hydrocortisone and hydrocortisone-ascorbic acid-thiamine (HAT) combined therapy as an adjuvant in the mortality rate of septic sho
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Yuniar, Irene, Vembricha Nindya Manusita, and Sonya Leonardy Low. "Corticosteroids for pediatric septic shock patients." Paediatrica Indonesiana 59, no. 2 (2019): 67–71. http://dx.doi.org/10.14238/pi59.2.2019.67-71.

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Background Septic shock remains a major cause of mortality and admission to the pediatric intensive care unit (PICU) in children. Management includes adequate fluid resuscitation, followed by catecholamine infusion, if needed. Corticosteroid therapy is advised for catecholamine-refractory shock, although this practice is controversial, as it was not beneficial in other studies.
 Objective To assess corticosteroid use in pediatric septic shock patients in Cipto Mangunkusumo Hospital.
 Methods This cross-sectional study included all patients aged 1 month-18 years with a diagnosis of se
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Litwak, Jane, Nam Cho, H. Nguyen, Kayvan Moussavi, and Thomas Bushell. "Vitamin C, Hydrocortisone, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Analysis of Real-World Application." Journal of Clinical Medicine 8, no. 4 (2019): 478. http://dx.doi.org/10.3390/jcm8040478.

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A recent study suggested mortality benefits using vitamin C, hydrocortisone, and thiamine combination therapy (triple therapy) in addition to standard care in patients with severe sepsis and septic shock. In order to further evaluate the effects of triple therapy in real-world clinical practice, we conducted a retrospective observational cohort study at an academic tertiary care hospital. A total of 94 patients (47 in triple therapy group and 47 in standard care group) were included in the analysis. Baseline characteristics in both groups were well-matched. No significant difference in the pri
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Parker, Margaret M., and Mitchell P. Fink. "Septic Shock." Journal of Intensive Care Medicine 7, no. 2 (1992): 90–100. http://dx.doi.org/10.1177/088506669200700206.

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The incidence of sepsis and septic shock has been increasing dramatically over the past 10 years. Despite advances in antimicrobial therapy, the mortality of septic shock remains very high. We review the clinical manifestations of sepsis and septic shock and describe the cardiovascular manifestations. Pathophysiology of the cardiovascular changes is discussed, and mediators believed to be involved in the pathogenesis are reviewed. Management of septic shock is also discussed, including antimicrobial therapy, supportive care, and adjunctive treatment aimed at affecting the mediators involved in
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Sutrisno, Wibowo, and Volodymyr Dzhyvak. "Assessing corticosteroid utilization and mortality risk in septic shock: insights from network meta-analysis." Deka in Medicine 1, no. 1 (2024): e791. http://dx.doi.org/10.69863/dim.v1i1.5.

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BACKGROUND: Despite current guidelines recommending corticosteroid administration in septic shock management, there is ongoing controversy regarding their impact on mortality rates and the most effective corticosteroid type. OBJECTIVES: To assess corticosteroid use and mortality risk in septic shock via network meta-analysis. METHODS: A comprehensive network meta-analysis was undertaken by retrieving articles from PubMed, Embase, and Scopus databases. Pertinent data encompassing baseline characteristics of articles, definitions of sepsis, types of corticosteroids employed, and mortality rates
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Kirov, M. Yu, V. V. Kuzkov, D. N. Protsenko, et al. "Septic shock in adults: guidelines of the All-Russian public organization “Federation of Anesthesiologists and Reanimatologists”." Annals of Critical Care, no. 4 (October 30, 2023): 7–42. http://dx.doi.org/10.21320/1818-474x-2023-4-7-42.

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The paper represents the clinical guidelines for septic shock in adults, approved by the All-Russian public organization “Federation of anesthesiologists and reanimatologists” in 2023. Septic shock is a widespread condition with a high mortality rate. The recommendations cover the issues of etiology, pathogenesis, clinical signs and symptoms, methods of laboratory and instrumental diagnosis of septic shock. The clinical guidelines present initial therapy for septic shock, including approaches to vasopressor and inotropic therapy, recommendations for choosing antibacterial drugs, fluid and adju
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Lamichhane, Sabitri, Nayan Manandhar, Shailendra Dhakal, and Yagya Laxmi Shakya. "Management and Outcome of Severe Sepsis and Septic Shock Patients." Journal of Nepal Health Research Council 16, no. 2 (2018): 165–71. http://dx.doi.org/10.33314/jnhrc.v16i2.985.

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Background: Severe sepsis and septic shock are major causes of morbidity and mortality worldwide and need immediate medical attention. Early recognition, fluid resuscitation and early antimicrobials are the mainstays of sepsis therapy. This study analyzed the management strategies of severe sepsis and septic shock and evaluated its impact.Methods: A prospective study was conducted on patients admitted through emergency department of Tribhuvan University Teaching Hospital of Nepal, who were diagnosed with severe sepsis and septic shock.Results: A total of 85 patients were diagnosed as severe se
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Epstein, Danny, Karawan Badarni, and Yaron Bar-Lavie. "Impact of Haemoadsorption Therapy on Short Term Mortality and Vasopressor Dependency in Severe Septic Shock with Acute Kidney Injury: A Retrospective Cohort Study." Antibiotics 13, no. 12 (2024): 1233. https://doi.org/10.3390/antibiotics13121233.

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Background/Objectives: Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, remains a major challenge in ICUs. This study evaluated whether combining haemoadsorption therapy with continuous renal replacement therapy (CRRT) reduces ICU and short-term mortality in patients with severe septic shock and acute kidney injury (AKI) requiring CRRT. Methods: A single-centre retrospective cohort study was conducted at Rambam Health Care Campus, Haifa, Israel, from January 2018 to February 2024. Data were collected from ICU patients with severe septic shock an
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Chae, Bora, Yo Sep Shin, Seok-In Hong, et al. "Extracellular Water to Total Body Water Ratio in Septic Shock Patients Receiving Protocol-Driven Resuscitation Bundle Therapy." Journal of Clinical Medicine 10, no. 13 (2021): 2917. http://dx.doi.org/10.3390/jcm10132917.

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(1) Bio-electrical impedance analysis (BIA) is a rapid, simple, and noninvasive tool for evaluating the metabolic status and for assessing volume status in critically ill patients. Little is known, however, the prognostic value of body composition analysis in septic shock patients. This study assessed the association between parameters by body composition analysis and mortality in patients with septic shock in the emergency department (ED). (2) Data were prospectively collected on adult patients with septic shock who underwent protocol-driven resuscitation bundle therapy between December 2019
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Rugg, Christopher, Riko Klose, Rouven Hornung, et al. "Hemoadsorption with CytoSorb in Septic Shock Reduces Catecholamine Requirements and In-Hospital Mortality: A Single-Center Retrospective ‘Genetic’ Matched Analysis." Biomedicines 8, no. 12 (2020): 539. http://dx.doi.org/10.3390/biomedicines8120539.

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Septic shock is a major burden to healthcare with mortality rates remaining high. Blood purification techniques aim to reduce cytokine levels and resultant organ failure. Regarding septic shock, hemoadsorption via CytoSorb seems promising, but the main effects on organ failure and mortality remain unclear. In this retrospective single-center study, septic shock patients receiving CytoSorb in addition to renal replacement therapy (n = 42) were analyzed and compared to matched controls (n = 42). A generalized propensity-score and Mahalanobis distance matching method (‘genetic’ matching) was appl
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Dissertations / Theses on the topic "Septic/mortality/therapy"

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Lemos, Manuel José Gonçalves. "Corticoterapia no Choque Séptico Refractário – Perspectiva em 2019: Revisão Sistemática e Meta-análise." Master's thesis, 2020. http://hdl.handle.net/10316/97779.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução : O choque séptico é uma entidade clínica resultante do agravamento da sépsis e tem uma taxa de mortalidade intra-hospitalar estimada entre 30% e 50%. O seu mecanismo fisiopatológico cursará com insuficiência adrenal relativa, o que sugere um potencial benefício no tratamento destes doentes com corticosteróides. Neste sentido, têm sido realizados vários estudos com o intuito de testar esta hipótese. Contudo, os resultados entre estudos têm sido díspares, de tal forma que a edição mais recente da
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Books on the topic "Septic/mortality/therapy"

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McGregor, Laura, Monica N. Gupta, and Max Field. Septic arthritis in adults. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0098.

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Septic arthritis (SA) is a medical emergency with mortality of around 15%. Presentation is usually monoarticular but in more than 10% SA affects two or more joints. Symptoms include rapid-onset joint inflammation with systemic inflammatory responses but fever and leucocytosis may be absent at presentation. Treatment according to British Society of Rheumatology/British Orthopaedic Association (BSR/BOA) guidelines should be commenced if there is a suspicion of SA. At-risk patients include those with primary joint disease, previous SA, recent intra-articular surgery, exogenous sources of infectio
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Bellomo, Rinaldo, and John R. Prowle. Pathophysiology of oliguria and acute kidney injury. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0211.

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Oliguria and acute kidney injury (AKI) are common in critically-ill patients with studies reporting AKI affecting more than 50% of critically-ill patients. AKI is independently associated with increased mortality and is a potentially modifiable aspect of critical illness. The pathogenesis of AKI is complex and varies according to aetiology. The most common trigger in ICU patients is sepsis—the pathophysiology of septic AKI is poorly understood and probably involves intrarenal haemodynamic and inflammatory processes. In the setting of septic AKI, the classic acute tubular necrosis described in
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Torres, Antoni, and Adamantia Liapikou. Diagnosis and management of community-acquired pneumonia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0116.

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Severe community-acquired pneumonia (SCAP) remains the most common infectious reason for admission to the intensive care unit (ICU), reaching a mortality rate of 30–40%. The microbial pattern of the SCAP has changed with S. pneumoniae still the leading pathogen, but a decrease of atypical pathogens, especially Legionella and an increase of viral and polymicrobial pneumonias. IDSA/ATS issued guidelines on the management of CAP including specific criteria to identify patients for ICU admission with good predictive value. The first selection of antimicrobial therapy should be started early coveri
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Jansen, Tim C., and Jan Bakker. Lactate monitoring in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0139.

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An increased blood lactate level (hyperlactataemia) is commonplace in critically-ill patients. Lactate is usually measured with the aim of detecting tissue hypoxia, but this is an oversimplification as aerobic processes can also result in increased levels. Understanding of the various anaerobic and aerobic mechanisms of production and clearance is essential for the correct interpretation of hyperlactataemia. Despite the broad differential diagnosis, hyperlactataemia generally predicts adverse outcomes. The consistency of its prognostic value emphasizes its place in the risk stratification of c
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Grisoli, Dominique, and Didier Raoult. Prevention and treatment of endocarditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0161.

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Initially always lethal, the prognosis of infective endocarditis (IE) has been revolutionized by antibacterial therapy and valve surgery. Nevertheless, it remains one of the deadliest infectious diseases, with ≥30% of patients dying within a year of diagnosis. Its incidence has also remained stable at 25–50 cases per million per year, and results predominantly from a combination of bacteraemia and a predisposing cardiac condition, including endocardial lesions and/or intracardiac foreign material. While antibiotic prophylaxis is recommended by various learned societies to cover healthcare proc
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Book chapters on the topic "Septic/mortality/therapy"

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Rivers, E., B. Nguyen, and S. Havstad. "Early goal-directed therapy prevents organ failure and mortality in severe sepsis and septic shock." In Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E. Springer Milan, 2003. http://dx.doi.org/10.1007/978-88-470-2215-7_38.

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Singh, Amandeep, and Aayush Chawla. "The Place of Crystalloids." In Rational Use of Intravenous Fluids in Critically Ill Patients. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-42205-8_9.

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AbstractCrystalloids are commonly used in medicine as solutions containing electrolytes dissolved in water, with or without glucose. They can be used as maintenance, replacement, or resuscitation fluids, but should be administered with caution. This chapter provides an overview of basic definitions, terminology, and concepts regarding crystalloids, including their categorization by tonicity, their balanced or unbalanced nature, and the importance of strong ion difference (SID). Improper administration of crystalloids can lead to morbidity, particularly hyperchloremic metabolic acidosis (HMA) a
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Arslantas, Mustafa Kemal, Tunc Asuroglu, Reyhan Arslantas, et al. "Using Machine Learning Methods to Predict the Lactate Trend of Sepsis Patients in the ICU." In Communications in Computer and Information Science. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-59091-7_1.

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AbstractSerum lactate levels are considered a biomarker of tissue hypoxia. In sepsis or septic shock patients, as suggested by The Surviving Sepsis Campaign, early lactate clearance-directed therapy is associated with decreased mortality; thus, serum lactate levels should be assessed. Monitoring a patient’s vital parameters and repetitive blood analysis may have deleterious effects on the patient and also bring an economic burden. Machine learning and trend analysis are gaining importance to overcome these issues. In this context, we aimed to investigate if a machine learning approach can pred
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Horvath, Ryan J., and Edward Bittner. "Hydrocortisone Therapy for Patients with Septic Shock." In 50 Studies Every Intensivist Should Know, edited by Edward A. Bittner and Michael E. Hochman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190467654.003.0049.

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This chapter provides a summary of the landmark study known as the CORTICUS trial. Among patients suffering from septic shock, does low dose hydrocortisone improve mortality? Starting with that question, it describes the basics of the study, including funding, study location, the population studies, number of patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case. The CORTICUS trial failed to demonstrate a ben
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Jibawi, Abdullah, Mohamed Baguneid, and Arnab Bhowmick. "Sepsis and septic shock." In Current Surgical Guidelines, edited by Abdullah Jibawi, Mohamed Baguneid, and Arnab Bhowmick. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198794769.003.0018.

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Sepsis is very common; however, goal–directed therapy significantly helps to reduce mortality rate following septic shock. Sepsis Six should be delivered within one hour of initial diagnosis of sepsis. The sepsis resuscitation and management bundle includes delivery of high flow O<sub>2</sub>, blood culture, measurement of lactate, empirical antibiotic therapy, and IV fluid resuscitation and renal support.
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Billimoria, Zeenia C., and Thomas V. Brogan. "Evidence and Management of a Rare Presentation in Neonatal ECMO." In Extracorporeal Membrane Oxygenation, edited by Marc O. Maybauer. Oxford University Press, 2022. http://dx.doi.org/10.1093/med/9780197521304.003.0023.

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Septic shock is a leading cause of morbidity and mortality in neonates. Sepsis results in the production of inflammatory mediators such as cytokines and chemokines, which lead to multiorgan failure. A small subset of neonates with severe septic shock require cardiorespiratory support with extracorporeal membrane oxygenation (ECMO) support. Therapeutic plasma exchange (TPE) is a means to remove inflammatory mediators from blood to treat severe septic shock. This chapter reviews the current literature on neonatal septic shock and the utility of extracorporeal therapies such as ECMO, continuous r
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"6 Treatment of the Septic Native Joint." In Management of Orthopaedic Infections, edited by Antonia F. Chen. Thieme Medical Publishers, Inc., 2021. http://dx.doi.org/10.1055/b-0041-181981.

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A septic native joint can be a debilitating condition that is associated with significant morbidity and mortality. Traditionally, a septic native joint was considered one of the few surgical emergencies in orthopaedics, as a delay in diagnosis and treatment can result in joint destruction and loss of joint mobility and even mortality. While prompt diagnosis is crucial, diagnosis can be challenging, as it can be difficult to differentiate between a septic native joint from crystalline arthropathy, and rheumatological and osteoarthritis flares. Diagnosis of a septic joint relies on clinical find
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Aydin, Ani, and Kusum S. Mathews. "Hot and shocky: Distributive/septic shock." In Critical Care Emergencies, edited by Lillian Liang Emlet. Oxford University PressNew York, 2023. http://dx.doi.org/10.1093/med/9780190082581.003.0012.

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Abstract This chapter reviews the most common form of distributive shock, septic shock, and its management. It discusses the significance of early goal-directed therapy (EGDT) in the treatment of sepsis and septic shock, and how the incorporation of portions of this algorithmic approach to septic shock treatment has led to a significant reduction in the mortality associated with this disease over the past 20 years. This chapter also examines current guideline recommendations and approaches to the treatment of septic shock, including fluid resuscitation, vasopressor use, and additional adjuncts
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McGregor, Laura, Monica N. Gupta, and Max Field. "Septic arthritis in adults." In Oxford Textbook of Rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0098_update_001.

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Septic arthritis (SA) is a medical emergency with mortality of around 15%. Presentation is usually monoarticular but in more than 10% SA affects two or more joints. Symptoms include rapid-onset joint inflammation with systemic inflammatory responses but fever and leucocytosis may be absent at presentation. Treatment according to British Society of Rheumatology/British Orthopaedic Association (BSR/BOA) guidelines should be commenced if there is a suspicion of SA. At-risk patients include those with primary joint disease, previous SA, recent intra-articular surgery, exogenous sources of infectio
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Chew, Michelle S. "Septic shock." In Oxford Textbook of Advanced Critical Care Echocardiography, edited by Anthony McLean, Stephen Huang, and Andrew Hilton. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198749288.003.0020.

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Failure or dysfunction of the cardiovascular system is the defining feature of septic shock. While there is now evidence for the central role of the heart in the pathophysiology of septic shock, it is important to remember that it is only one component of the cardiovascular system. Thus, it is often impossible to distinguish between the direct effects of sepsis on the heart and its responses to other changes in the cardiovascular system. Systolic, diastolic, left, and right heart functions are variably affected and are not mutually exclusive. They may be associated with rises in cardiac tropon
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Conference papers on the topic "Septic/mortality/therapy"

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Arabi, Yaseen, Nehad Shirawi, Ziad Memish, et al. "Inappropriate Initial Antimicrobial Therapy In Cirrhotic Patients With Septic Shock Is Associated With A Great Increase In Mortality." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4691.

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Amalakuhan, Bravein, Nadine Srouji, Arvin Parvathaneni, Rethea Deveney, Julianne Rich, and Safa Farzin. "A Hospital Wide "Sepsis-Alert" System: Going A Step Beyond Classical "Early Goal Directed Therapy" For Severe Sepsis/Septic Shock And Improving Mortality And Health-Care Expenditure On A Global Level." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4001.

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Reports on the topic "Septic/mortality/therapy"

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Protocol-led therapy for septic shock did not reduce mortality compared to usual resuscitation care. National Institute for Health Research, 2015. http://dx.doi.org/10.3310/signal-000166.

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