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1

J, Sibbald William, and Sprung Charles L, eds. Perspectives on sepsis and septic shock. Society of Critical Care Medicine, 1986.

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2

Sakorafas, George H. Septic shock: Current pathogenetic concepts, optimal management, and future perspectives. Nova Biomedical Books, 2004.

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3

Jordi, Rello, and Restrepo Marcos I, eds. Sepsis: New strategies for management. Springer, 2008.

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4

Society of Critical Care Medicine, ed. Fundamental disaster management. 3rd ed. Society of Critical Care Medicine, 2009.

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5

Septic Shock (Critical Care Management). HARCOURT PUBLISHERS LIMITED, 2000.

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6

Graver, Benedict. Septic Shock: Risk Factors, Management and Prognosis. Nova Science Publishers, Incorporated, 2015.

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7

Septic Shock: Symptoms, Management and Risk Factors. Nova Science Pub Inc, 2012.

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8

Sakorafas, George H. Septic Shock: Current Pathogenetic Concepts, Optimal Management, And Future Perspectives (Nova Biomedical). Nova Biomedical Books, 2006.

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9

Peake, Sandra L., and Matthew J. Maiden. Management of septic shock in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0298.

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The management of septic shock is a medical emergency. Following prompt recognition, treatment priorities are haemodynamic resuscitation, empirical antimicrobials, urgent control of the source of infection and monitoring the response to therapy. Haemodynamic resuscitation is focused on maintaining an adequate macrocirculation, while also ensuring adequacy of microcirculatory blood flow to the cells. Intravenous fluids and catecholamines have been the mainstay of therapy. However, the amount and type of fluids, choice of vasoactive medications, and the appropriate resuscitation endpoints have b
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10

Rello, Jordi, and Marcos I. Restrepo. Sepsis: New Strategies for Management. Springer, 2010.

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11

Leach, Dr Richard, and Professor Derek Bell. Fluid management and nutrition. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199565979.003.0002.

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Chapter 2 covers fluid management and nutrition, including information about assessment of the circulation, fluid management, shock states, SIRS, sepsis, severe sepsis, septic shock, vasopressor and inotropic therapy, and nutrition.
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12

Pang, Diana, and Joseph A. Carcillo. Pediatric Shock. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199918027.003.0008.

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The chapter on pediatric shock recognition and management provides essential information on types of shock and its management. It contains summaries of hypovolemic, hemorrhagic, cardiogenic, vasoplegic, septic, metabolic, and dysoxic shock. All types of shock are best treated when therapy is targeted toward achieving specific goals (goal-directed therapy), and this chapter provides guidelines for clinical, hemodynamic, and biochemical goals. To achieve those goals, the chapter also provides guidelines on the use of key therapies, including isotonic crystalloid and colloid, blood products, cate
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13

Torres, Antoni, and Adamantia Liapikou. Diagnosis and management of community-acquired pneumonia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0116.

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Severe community-acquired pneumonia (SCAP) remains the most common infectious reason for admission to the intensive care unit (ICU), reaching a mortality rate of 30–40%. The microbial pattern of the SCAP has changed with S. pneumoniae still the leading pathogen, but a decrease of atypical pathogens, especially Legionella and an increase of viral and polymicrobial pneumonias. IDSA/ATS issued guidelines on the management of CAP including specific criteria to identify patients for ICU admission with good predictive value. The first selection of antimicrobial therapy should be started early coveri
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14

Lapsia, Munish H., and David T. Huang. Sepsis (DRAFT). Edited by Raghavan Murugan and Joseph M. Darby. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190612474.003.0013.

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Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. This chapter focuses on the first 30 minutes of care for those patients with sepsis in the context of the rapid response team (RRT) activation. The definitions, etiology, incidence, and risk factors for sepsis are reviewed. Recognition of infection, sepsis, and septic shock is also reviewed while highlighting the use of sequential sepsis related organ failure assessment (SOFA) and quick SOFA (qSOFA) scores for diagnosis of sepsis. This chapter also discusses the initial fluid resuscitat
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15

Nolan, Jerry. The critically ill patient. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198719410.003.0035.

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This chapter discusses the anaesthetic management of the critically ill patient suffering from trauma or life-threatening illness. It begins by describing the principles of immediate trauma care, and the primary and secondary surveys. It then goes into more detail about head injuries, chest injuries, abdominal injuries, pelvic fractures, spinal injuries, limb injuries, burns, multiple trauma, post-cardiac arrest resuscitation care, and septic shock. It concludes by describing the transfer of the critically ill patient to the operating theatre or to another unit.
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16

Nolan, Jerry. The critically ill patient. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198719410.003.0035_update_001.

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This chapter discusses the anaesthetic management of the critically ill patient suffering from trauma or life-threatening illness. It begins by describing the principles of immediate trauma care, and the primary and secondary surveys. It then goes into more detail about head injuries, chest injuries, abdominal injuries, pelvic fractures, spinal injuries, limb injuries, burns, multiple trauma, post-cardiac arrest resuscitation care, and septic shock. It concludes by describing the transfer of the critically ill patient to the operating theatre or to another unit.
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17

Vieillard-Baron, Antoine. Right ventricular function in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0135.

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Under normal conditions, the right ventricle (RV) virtually acts as a passive conduit. In critically-ill patients many situations induce uncoupling between the right ventricle and pulmonary circulation, leading to RV systolic dysfunction, then failure. Mechanical ventilation has a major impact by decreasing RV preload, but also significantly increasing RV afterload. RV function should thus always be interpreted and re-evaluated in the light of respiratory mechanics and ventilator settings. RV systolic function is key to the patient’s haemodynamic profile and must be monitored to achieve optima
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18

Spevetz, Antoinette, and Joseph E. Parrillo. Diagnosis and management of shock in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0150.

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Sepsis is triggered by an infection and treatment of sepsis requires timely identification of the patient, and rapid treatment with antibiotics, source control, and fluids. In the absence of a true biomarker for sepsis, the clinician needs to recognize which patients are at risk, as well as the common signs and symptoms of infection. The site of infection, the patient’s phenotype, and the location of the patient will help drive decisions about initial antibiotic therapy. Patients with sepsis should be treated to ensure adequate cardiac output and organ perfusion, which usually requires infusio
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19

Evans, Charlotte, Anne Creaton, Marcus Kennedy, and Terry Martin, eds. Further reading. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198722168.003.0022.

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General, Retrieval coordination, The retrieval environment, Equipment, Crisis resource management, Respiratory support, Cardiac, Shock, Sepsis, Neurosurgery and neurology, Obstetrics, Behavioural disturbance, Obesity, Primary retrieval, Trauma, Neonatal retrieval, Specialized retrieval systems, Checklists
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20

Grisoli, Dominique, and Didier Raoult. Prevention and treatment of endocarditis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0161.

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Initially always lethal, the prognosis of infective endocarditis (IE) has been revolutionized by antibacterial therapy and valve surgery. Nevertheless, it remains one of the deadliest infectious diseases, with ≥30% of patients dying within a year of diagnosis. Its incidence has also remained stable at 25–50 cases per million per year, and results predominantly from a combination of bacteraemia and a predisposing cardiac condition, including endocardial lesions and/or intracardiac foreign material. While antibiotic prophylaxis is recommended by various learned societies to cover healthcare proc
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21

Whitty, Christopher J. M. Diagnosis and management of malaria in the ICU. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0292.

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Falciparum malaria is the commonest life-threatening imported tropical infection. The most important critical care intervention is rapid high-dose antimalarial treatment with artesunate, or if that is not available quinine. The common complications of malaria are different in children and adults. Cerebral malaria may occur in both, for which there is no specific therapy. Renal failure and acute lung injury are much more common in adults, and may occur late in the course of the disease, even after parasites have cleared. In children acidosis, anaemia and Gram-negative sepsis are more common. Re
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22

Erlinge, David, and Göran Olivecrona. Diagnosis and management of ST-elevation of myocardial infarction. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0147.

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ST-elevation myocardial infarction (STEMI) is generally caused by a ruptured plaque that triggers local thrombus formation, which occludes the coronary artery. STEMI should be diagnosed rapidly, based on the combination of ST-segment elevation and symptoms of acute myocardial infarction. The main treatment objective is myocardial tissue reperfusion as quickly as possible. The preferred method of reperfusion is primary percutaneous coronary interventionif transport time is below 2 hours, and thrombolysis if longer STEMI patients with acute onset cardiogenic shock should be evaluated by echocard
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23

Rickman, Otis B. Critical Care Medicine. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199755691.003.0148.

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Critical care medicine is a multidisciplinary branch of medicine encompassing the provision of organ support to patients who are severely ill. All areas of medicine may have relevance for critically ill patients; however, this review focuses only on aspects of cardiopulmonary monitoring, life support, technologic interventions, and disease states typically managed in the intensive care unit (ICU). Airway management, venous access, respiratory failure, mechanical ventilation, acute respiratory distress syndrome, shock, and sepsis are reviewed.
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24

Evans, Dr Charlotte, Professor Anne Creaton, Dr Marcus Kennedy, and Dr Terry Martin, eds. Retrieval Medicine. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198722168.001.0001.

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Retrieval Medicine is the practice of acute, emergency, and critical care medicine in the ‘transport’ environment. It requires medical practitioners to function independently in highly variable and resource-limited environments, in transport settings, and in the field, with acutely unwell, unstable and often clinically undifferentiated patients over long durations. This handbook covers the complex problems in the retrieval environment. It covers retrieval systems, governance, and coordination; the retrieval environment; and retrieval platforms, as well as equipment. It also involves crisis res
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25

Johnson, Steven B. Pathophysiology and management of abdominal injury. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0334.

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Abdominal injuries are common following blunt and penetrating trauma. They can result in a spectrum of severity from benign to potentially life-threatening conditions. Soon after injury, haemorrhage is the predominant concern, and leading cause of morbidity and mortality. Active haemorrhage resulting in shock requires emergent operative intervention and aggressive haemostatic resuscitation. However haemodynamically-stable patients benefit from non-operative management of solid organ injuries with or without angiographic embolization. Sepsis usually occurs as a result of intra-abdominal infecti
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26

Wild, Jonathan, Emma Nofal, Imeshi Wijetunga, and Antonia Durham Hall. Emergency surgery (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198749813.003.0007.

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Emergency general surgery comprises patients with surgical problems requiring surgical intervention or post-operative surgical patients who require further surgical intervention or symptom palliation at any time of the day or night. Beyond the cases discussed below, this will include also emergency presentations from all of the sub-specialty chapters covered so far. Over 600,000 emergency hospital admissions are made to general surgery. Of these patients, they comprise the sickest patient cohort relative to the majority of elective patients, which results from sepsis, shock, or organ dysfuncti
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