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Journal articles on the topic 'Septic shock management'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Howell, Michael D., and Andrew M. Davis. "Management of Sepsis and Septic Shock." JAMA 317, no. 8 (2017): 847. http://dx.doi.org/10.1001/jama.2017.0131.

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2

Yovita, Koswara, and Widianto Sudjud Reza. "Management of Septic Shock According to SSC 2016 in Post Laparotomy Exploration due to Gastric Perforation." Journal of Health and Medical Sciences 3, no. 2 (2020): 177–83. https://doi.org/10.31014/aior.1994.03.02.112.

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According to International Guidelines for Management of Sepsis and Septic Shock 2016, sepsis was defined as life threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis and septic shock are major healthcare problems and the incidence increased by year. Septic Shock was defined as subset of sepsis in which underlying circulatory and cellular metabolism abnormalities are profound enough to substantially increase mortality and can be identified with persisting hypotension requiring vasopressors to maintain MAP>65mmHg and having serum lactate level > 2 mmo/L

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3

Berger, Rebecca E., Emanuel Rivers, and Mitchell M. Levy. "Management of Septic Shock." New England Journal of Medicine 376, no. 23 (2017): 2282–85. http://dx.doi.org/10.1056/nejmclde1705277.

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4

Lynn, William A., and Jonathan Cohen. "Management of septic shock." Journal of Infection 30, no. 3 (1995): 207–12. http://dx.doi.org/10.1016/s0163-4453(95)90670-3.

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5

Edwards, J. D. "Management of septic shock." BMJ 306, no. 6893 (1993): 1661–64. http://dx.doi.org/10.1136/bmj.306.6893.1661.

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6

Edwards, J. D. "Management of septic shock." BMJ 307, no. 6905 (1993): 683. http://dx.doi.org/10.1136/bmj.307.6905.683.

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7

Vincent, Jean-Louis, Frederico Bruzzi de Carvalho, and Daniel De Backer. "Management of Septic Shock." Annals of Medicine 34, no. 7 (2002): 606–13. http://dx.doi.org/10.1080/078538902321117832.

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8

Haskins, Steve C. "Management of septic shock." Journal of the American Veterinary Medical Association 200, no. 12 (1992): 1915–17. http://dx.doi.org/10.2460/javma.1992.200.12.1915.

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9

Al-alousi, Wajeeh H., and Alla H. Ali. "management of septic shock." Journal of the Faculty of Medicine Baghdad 47, no. 4 (2006): 352–54. http://dx.doi.org/10.32007/jfacmedbagdad.4741585.

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10

Al-Hanuf, Jamal Ahmed Al-Bokhari Fatmah Ibrahim AlAbdullah Hazem Faisal Alotaibi Rohiya Emad Hejazi Faris Matouq Almowalad Adel Saleh Alanazi Laila khalid alanazi Nadiah Mohammadidris Ali Johar Mohammed Abdullah Mohammed Asiri Meshal Abdulrahman Hassan Ogran Ahmad Abdulaziz M. Almehmadi. "MANAGEMENT OF SEPTIC SHOCK." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 711–15. https://doi.org/10.5281/zenodo.2536237.

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<strong><em>Introduction:</em></strong><em> Sepsis is known as the systemic inflammatory response to infection. Sepsis is a very critical as it is seen in ten of thousand hospitalized patients and multiple organ dysfunction syndrome (MODS) could develop in about thirty percent ofof these patients; mortality is observed in twenty percent of patients with sepsis and eighty percent of patients with septic shock. Early diagnosis and management are crucial because of very high mortality rates. Advances in the field of molecular biology have assisted us understand most pathologic events that occur i

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11

Dugar, Siddharth, Chirag Choudhary, and Abhijit Duggal. "Sepsis and septic shock: Guideline-based management." Cleveland Clinic Journal of Medicine 87, no. 1 (2020): 53–64. http://dx.doi.org/10.3949/ccjm.87a.18143.

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12

Sessler, Curtis N., John C. Perry, and Kimberly L. Varney. "Management of severe sepsis and septic shock." Current Opinion in Critical Care 10, no. 5 (2004): 354–63. http://dx.doi.org/10.1097/01.ccx.0000139363.76068.7b.

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13

Sharma, Sat, and Anand Kumar. "Antimicrobial Management of Sepsis and Septic Shock." Clinics in Chest Medicine 29, no. 4 (2008): 677–87. http://dx.doi.org/10.1016/j.ccm.2008.06.004.

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14

Lamichhane, Sabitri, Nayan Manandhar, Shailendra Dhakal, and Yagya Laxmi Shakya. "Management and Outcome of Severe Sepsis and Septic Shock Patients." Journal of Nepal Health Research Council 16, no. 2 (2018): 165–71. http://dx.doi.org/10.33314/jnhrc.v16i2.985.

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Background: Severe sepsis and septic shock are major causes of morbidity and mortality worldwide and need immediate medical attention. Early recognition, fluid resuscitation and early antimicrobials are the mainstays of sepsis therapy. This study analyzed the management strategies of severe sepsis and septic shock and evaluated its impact.Methods: A prospective study was conducted on patients admitted through emergency department of Tribhuvan University Teaching Hospital of Nepal, who were diagnosed with severe sepsis and septic shock.Results: A total of 85 patients were diagnosed as severe se

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15

Eko, Setijanto1 Rafael Bagus Yudhistira2*. "Perioperative Anesthetic Management in a Geriatric Patient with Septic Shock Undergoing Emergency Laparotomy: A Case Report." ISRG Journal of Clinical Medicine and Medical Research [ISRGJCMMR] II, no. II (2025): 1–4. https://doi.org/10.5281/zenodo.14955026.

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<strong>Abstract</strong> <strong><em>Background:</em></strong><em> Septic shock in geriatric patients is associated with high mortality due to physiological changes, impaired immune response, and altered pharmacokinetics. Managing anesthesia in this population requires a careful balance between hemodynamic stabilization, appropriate drug selection, and ventilatory support. Emergency laparotomy for septic shock further increases perioperative risks, necessitating an individualized anesthetic approach.</em> <strong><em>Aims:</em></strong><em> This case report aims to describe the perioperative

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16

Parker, Margaret M., and Mitchell P. Fink. "Septic Shock." Journal of Intensive Care Medicine 7, no. 2 (1992): 90–100. http://dx.doi.org/10.1177/088506669200700206.

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The incidence of sepsis and septic shock has been increasing dramatically over the past 10 years. Despite advances in antimicrobial therapy, the mortality of septic shock remains very high. We review the clinical manifestations of sepsis and septic shock and describe the cardiovascular manifestations. Pathophysiology of the cardiovascular changes is discussed, and mediators believed to be involved in the pathogenesis are reviewed. Management of septic shock is also discussed, including antimicrobial therapy, supportive care, and adjunctive treatment aimed at affecting the mediators involved in

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17

Genga, Kelly Roveran, Tadanaga Shimada, John H. Boyd, Keith R. Walley, and James A. Russell. "The Understanding and Management of Organism Toxicity in Septic Shock." Journal of Innate Immunity 10, no. 5-6 (2018): 502–14. http://dx.doi.org/10.1159/000487818.

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The toxicity caused by different organisms in septic shock is substantially complex and characterized by an intricate pathogenicity that involves several systems and pathways. Immune cells’ pattern recognition receptors initiate the host response to pathogens after the recognition of pathogen-associated molecular patterns. In essence, the subsequent activation of downstream pathways may progress to infection resolution or to a dysregulated host response that represents the hallmark of organ injury in septic shock. Likewise, the management of organism toxicity in septic shock is complicated and

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18

Saugel, Bernd, Wolfgang Huber, Axel Nierhaus, Stefan Kluge, Daniel A. Reuter, and Julia Y. Wagner. "Advanced Hemodynamic Management in Patients with Septic Shock." BioMed Research International 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/8268569.

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In patients with sepsis and septic shock, the hemodynamic management in both early and later phases of these “organ dysfunction syndromes” is a key therapeutic component. It needs, however, to be differentiated between “early goal-directed therapy” (EGDT) as proposed for the first 6 hours of emergency department treatment by Rivers et al. in 2001 and “hemodynamic management” using advanced hemodynamic monitoring in the intensive care unit (ICU). Recent large trials demonstrated that nowadays protocolized EGDT does not seem to be superior to “usual care” in terms of a reduction in mortality in

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19

Fitch, Stephen J., and James R. Gossage. "Optimal management of septic shock." Postgraduate Medicine 111, no. 3 (2002): 53–66. http://dx.doi.org/10.3810/pgm.2002.03.1133.

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20

Alexopoulos, Konstantinos. "Anesthetic Management of Septic Shock." University of Western Ontario Medical Journal 83, S1 (2015): 8–9. http://dx.doi.org/10.5206/uwomj.v83is1.4398.

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21

Vincent, Jean-Louis. "Cardiovascular Management of Septic Shock." Infectious Disease Clinics of North America 5, no. 4 (1991): 807–16. http://dx.doi.org/10.1016/s0891-5520(20)30757-1.

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22

Dellinger, R. Phillip. "Cardiovascular management of septic shock." Critical Care Medicine 31, no. 3 (2003): 946–55. http://dx.doi.org/10.1097/01.ccm.0000057403.73299.a6.

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23

Pravinkumar, Egbert. "Cardiovascular Management of Septic Shock." Critical Care Medicine 32, no. 1 (2004): 315. http://dx.doi.org/10.1097/01.ccm.0000098854.97086.2f.

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24

Saugel, Bernd, Constantin J. Trepte, Kai Heckel, Julia Y. Wagner, and Daniel A. Reuter. "Hemodynamic Management of Septic Shock." Shock 43, no. 6 (2015): 522–29. http://dx.doi.org/10.1097/shk.0000000000000345.

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25

Hassan, Erkan. "The Management of Septic Shock." Journal of Pharmacy Practice 11, no. 6 (1998): 486–501. http://dx.doi.org/10.1177/089719009801100607.

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26

De Backer, Daniel. "Hemodynamic management of septic shock." Current Infectious Disease Reports 8, no. 5 (2006): 366–72. http://dx.doi.org/10.1007/s11908-006-0047-z.

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27

Balik, Martin, Vojtech Matousek, Michal Maly, and Tomas Brozek. "Management of arrhythmia in sepsis and septic shock." Anestezjologia Intensywna Terapia 49, no. 5 (2017): 419–29. http://dx.doi.org/10.5603/ait.a2017.0061.

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28

Chiotos, Kathleen, Fran Balamuth, and Halden Scott. "Management of bacterial severe sepsis and septic shock." Journal of Pediatric Intensive Care 03, no. 04 (2015): 227–42. http://dx.doi.org/10.3233/pic-14105.

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29

Lee, Jung Hyun. "Adjunctive Management of Neonatal Sepsis and Septic Shock." Journal of the Korean Society of Neonatology 19, no. 2 (2012): 65. http://dx.doi.org/10.5385/jksn.2012.19.2.65.

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30

Thompson, Kelly, Balasubramanian Venkatesh, and Simon Finfer. "Sepsis and septic shock: current approaches to management." Internal Medicine Journal 49, no. 2 (2019): 160–70. http://dx.doi.org/10.1111/imj.14199.

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31

Puskarich, Michael A. "Emergency management of severe sepsis and septic shock." Current Opinion in Critical Care 18, no. 4 (2012): 295–300. http://dx.doi.org/10.1097/mcc.0b013e328354dc16.

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32

Morrell, Matthew R., Scott T. Micek, and Marin H. Kollef. "The Management of Severe Sepsis and Septic Shock." Infectious Disease Clinics of North America 23, no. 3 (2009): 485–501. http://dx.doi.org/10.1016/j.idc.2009.04.002.

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33

Satterwhite, Lewis, and Heath Latham. "Fluid Management in Sepsis Hypotension and Septic Shock." Chest 158, no. 4 (2020): 1319–20. http://dx.doi.org/10.1016/j.chest.2020.05.524.

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34

Islamy, Nurul, M. Alamsyah Aziz, Ade Yonata, et al. "Sepsis and Septic Shock in Pregnancy." Journal La Medihealtico 6, no. 2 (2025): 238–50. https://doi.org/10.37899/journallamedihealtico.v6i2.1863.

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Sepsis during pregnancy is a critical condition that leads to organ dysfunction due to an abnormal response to infection. It remains a significant cause of maternal morbidity and mortality worldwide. The World Health Organization (WHO) reports a global prevalence of 4.4% of live births affected by maternal sepsis, with varying incidences across countries. Sepsis ranks among the top five causes of maternal deaths globally, contributing to 12.7% of pregnancy-related mortality in the United States. The physiological changes during pregnancy, such as increased blood volume and immune response modu

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35

Biban, Paolo, Marcella Gaffuri, Stefania Spaggiari, Federico Zaglia, Alessandra Serra, and Pierantonio Santuz. "Early recognition and management of septic shock in children." Pediatric Reports 4, no. 1 (2012): 13. http://dx.doi.org/10.4081/pr.2012.e13.

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Septic shock remains a major cause of morbidity and mortality among children, mainly due to acute haemodynamic compromise and multiple organ failures. In the last decade, international guidelines for the management of septic shock, as well as clinical practice parameters for hemodynamic support of pediatric patients, have been published. Early recognition and aggressive therapy of septic shock, by means of abundant fluid resuscitation, use of catecholamines and other adjuvant drugs, are widely considered of pivotal importance to improve the short and long-term outcome of these patients. The ai

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36

Vekaria-Hirani, Varsha, Rashmi Kumar, Rachel N. Musoke, Ezekiel M. Wafula, and Idris N. Chipkophe. "Prevalence and Management of Septic Shock among Children Admitted at the Kenyatta National Hospital, Longitudinal Survey." International Journal of Pediatrics 2019 (December 17, 2019): 1–8. http://dx.doi.org/10.1155/2019/1502963.

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Background. Paediatric septic shock is a subset of sepsis associated with high mortality. Implementing the existing international Surviving Sepsis Campaign Guidelines 2012 (SSCG) have contributed to reduction of mortality in many places but these have not been adopted in our setting. The current study aimed at documenting the practice at a national referral hospital. Methods. A hospital based longitudinal survey carried out among 325 children from September to October 2016. Children aged 0 days (≥37 weeks gestation) to12 years were included. The aim was to determine the prevalence, audit the m

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37

Gavelli, Francesco, Luigi Mario Castello, and Gian Carlo Avanzi. "Management of sepsis and septic shock in the emergency department." Internal and Emergency Medicine 16, no. 6 (2021): 1649–61. http://dx.doi.org/10.1007/s11739-021-02735-7.

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AbstractEarly management of sepsis and septic shock is crucial for patients’ prognosis. As the Emergency Department (ED) is the place where the first medical contact for septic patients is likely to occur, emergency physicians play an essential role in the early phases of patient management, which consists of accurate initial diagnosis, resuscitation, and early antibiotic treatment. Since the issuing of the Surviving Sepsis Campaign guidelines in 2016, several studies have been published on different aspects of sepsis management, adding a substantial amount of new information on the pathophysi

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38

Rakotoarisoa Josoa, Andrianiaina, Rabenjarison Francklin, Tofotranjara Heriniaina Aldino, Rakotomavo Falihery Albertin, and Raveloson Nasolotsiry Enintsoa. "ASPECTS CLINIQUES ET EVOLUTIFS DU CHOC SEPTIQUE EN REANIMATION DU CHU ANDOHATAPENAKA." International Journal of Advanced Research 12, no. 02 (2024): 569–76. http://dx.doi.org/10.21474/ijar01/18333.

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Introduction: Septic shock is a major problem in intensive care units because it is responsible for high mortality. We aim to describe septic shocks clinical, bacteriological, therapeutic, and outcome aspects in the Intensive Care Department of Andohatapenaka University Hospital. Methods: This is a 30-month retrospective descriptive study of patients admitted with septic shock to the intensive care unit of CHU Andohatapenaka. The parameters studied were sociodemographic data, clinical parameters, bacteriological parameters, and evolutionary outcomes. Results: The incidence of septic shock was

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39

Moss, Stephanie R., and Hallie C. Prescott. "Current Controversies in Sepsis Management." Seminars in Respiratory and Critical Care Medicine 40, no. 05 (2019): 594–603. http://dx.doi.org/10.1055/s-0039-1696981.

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AbstractThe overarching goals of early sepsis management include early recognition, appropriate antibiotic therapy and source control, maintenance of hemodynamic stability, and supportive care of organ dysfunction. Despite increasing awareness of the global burden of sepsis, and general agreement on the goals of management, there is ongoing controversy regarding the implementation of specific treatment strategies to optimize patient outcomes. This article will address five current points of controversy in the management of sepsis and septic shock. These include optimal timing of antibiotics in

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40

Muhammad Imam, Muhammad Imam, and Sebastian Sebastian. "Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock." International Journal of Medical Science and Health Research 2, no. 7 (2024): 22–29. https://doi.org/10.70070/7036j221.

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Background: The exploration of the effects of selepressin versus placebo in patients experiencing septic shock is an emerging area of interest in critical care medicine. The literature surrounding this topic reveals a complex interplay between vasopressor use, patient outcomes, and potential complications associated with septic shock management. Literature Review: The literature surrounding the effects of selepressin versus placebo in patients with septic shock reveals a nuanced understanding of its potential benefits and limitations in critical care settings. The introduction highlights the s

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41

Nishie, Hiroyuki. "Guidelines for management of severe sepsis and septic shock." Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 125, no. 2 (2013): 153–57. http://dx.doi.org/10.4044/joma.125.153.

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42

Donovan, Anne L., and David Shimabukuro. "Protocol-Based Management of Severe Sepsis and Septic Shock." Current Anesthesiology Reports 5, no. 4 (2015): 407–18. http://dx.doi.org/10.1007/s40140-015-0124-7.

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43

Rauf-ul-Hassan, Muahmmad, Seemal Aslam, Muhammad Waseem, Imran Bashir, Shafia Naz, and Ahtesham Iqbal. "Effect of hydrocortisone on outcome of septic shock patients. A prospective observational study in a tertiary care ICU." Pakistan Journal of Medical and Health Sciences 16, no. 2 (2022): 315–17. http://dx.doi.org/10.53350/pjmhs22162315.

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Introduction: Sepsis and septic shock have 10% and 40% mortality in ICU respectively. Early recognition and prompt management of septic shock in ICU can reduce mortality. Further, some studies have suggested that hydrocortisone can impact outcome of septic shock significantly. Methodology: We designed prospective observational study to evaluate the effect of hydrocortisone in septic shock patients. Septic shock was defined according to definition proposed by international consensus definition of septic shock 2016. We excluded those who were less than 18 years and receiving steroids for some ot

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44

Lee, Wesley, David B. Cotton, Gary D. V. Hankins, and Sebastian Faro. "Management of Septic Shock Complicating Pregnancy." Obstetrics and Gynecology Clinics of North America 16, no. 2 (1989): 431–47. http://dx.doi.org/10.1016/s0889-8545(21)00169-8.

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45

Kleinman, M. E. "Pre-Transport Management of Septic Shock." AAP Grand Rounds 11, no. 2 (2004): 21. http://dx.doi.org/10.1542/gr.11-2-21.

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46

Sparrow, Annie, and Frank Willis. "Management of septic shock in childhood." Emergency Medicine Australasia 16, no. 2 (2004): 125–34. http://dx.doi.org/10.1111/j.1742-6723.2004.00564.x.

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47

Parker, Margaret M. "Hemodynamic Management in Pediatric Septic Shock." Pediatric Critical Care Medicine 15, no. 1 (2014): 90–91. http://dx.doi.org/10.1097/01.pcc.0000436126.70886.e8.

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48

Mostow, Steven R. "Management of Gram-Negative Septic Shock." Hospital Practice 25, no. 10 (1990): 121–30. http://dx.doi.org/10.1080/21548331.1990.11704024.

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49

Vincent, Jean-Louis, Diego Orbegozo Cortés, and Angela Acheampong. "Current haemodynamic management of septic shock." La Presse Médicale 45, no. 4 (2016): e99-e103. http://dx.doi.org/10.1016/j.lpm.2016.03.005.

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50

Luce, John M. "Pathogenesis and Management of Septic Shock." Chest 91, no. 6 (1987): 883–88. http://dx.doi.org/10.1378/chest.91.6.883.

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