Relevant bibliographies by topics / Septin 4

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Academic literature on the topic 'Septin 4'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Septin 4"

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Shinoda, Tomoyasu, Hidenori Ito, Kaori Sudo, Ikuko Iwamoto, Rika Morishita, and Koh-ichi Nagata. "Septin 14 Is Involved in Cortical Neuronal Migration via Interaction with Septin 4." Molecular Biology of the Cell 21, no. 8 (April 15, 2010): 1324–34. http://dx.doi.org/10.1091/mbc.e09-10-0869.

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Septins are a family of conserved guanosine triphosphate/guanosine diphosphate-binding proteins implicated in a variety of cellular functions such as cell cycle control and cytokinesis. Although several members of septin family, including Septin 14 (Sept14), are abundantly expressed in nervous tissues, little is known about their physiological functions, especially in neuronal development. Here, we report that Sept14 is strongly expressed in the cortical plate of developing cerebral cortex. Knockdown experiments by using the method of in utero electroporation showed that reduction of Sept14 caused inhibition of cortical neuronal migration. Whereas cDNA encoding RNA interference-resistant Sept14 rescued the migration defect, the C-terminal deletion mutant of Sept14 did not. Biochemical analyses revealed that C-terminal coiled-coil region of Sept14 interacts with Septin 4 (Sept4). Knockdown experiments showed that Sept4 is also involved in cortical neuronal migration in vivo. In addition, knockdown of Sept14 or Sept4 inhibited leading process formation in migrating cortical neurons. These results suggest that Sept14 is involved in neuronal migration in cerebral cortex via interaction with Sept4.
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Onishi, Masayuki, Takako Koga, Aiko Hirata, Taro Nakamura, Haruhiko Asakawa, Chikashi Shimoda, Jürg Bähler, et al. "Role of Septins in the Orientation of Forespore Membrane Extension during Sporulation in Fission Yeast." Molecular and Cellular Biology 30, no. 8 (February 1, 2010): 2057–74. http://dx.doi.org/10.1128/mcb.01529-09.

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ABSTRACT During yeast sporulation, a forespore membrane (FSM) initiates at each spindle-pole body and extends to form the spore envelope. We used Schizosaccharomyces pombe to investigate the role of septins during this process. During the prior conjugation of haploid cells, the four vegetatively expressed septins (Spn1, Spn2, Spn3, and Spn4) coassemble at the fusion site and are necessary for its normal morphogenesis. Sporulation involves a different set of four septins (Spn2, Spn5, Spn6, and the atypical Spn7) that does not include the core subunits of the vegetative septin complex. The four sporulation septins form a complex in vitro and colocalize interdependently to a ring-shaped structure along each FSM, and septin mutations result in disoriented FSM extension. The septins and the leading-edge proteins appear to function in parallel to orient FSM extension. Spn2 and Spn7 bind to phosphatidylinositol 4-phosphate [PtdIns(4)P] in vitro, and PtdIns(4)P is enriched in the FSMs, suggesting that septins bind to the FSMs via this lipid. Cells expressing a mutant Spn2 protein unable to bind PtdIns(4)P still form extended septin structures, but these structures fail to associate with the FSMs, which are frequently disoriented. Thus, septins appear to form a scaffold that helps to guide the oriented extension of the FSM.
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Tsang, Christopher W., Mathew P. Estey, Jessica E. DiCiccio, Hong Xie, Dana Patterson, and William S. Trimble. "Characterization of presynaptic septin complexes in mammalian hippocampal neurons." Biological Chemistry 392, no. 8-9 (August 1, 2011): 739–49. http://dx.doi.org/10.1515/bc.2011.077.

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Abstract Septins are GTPases that form heteromeric complexes and are linked to neurological disorders. Although several septin subcomplexes have been reported in various mammalian tissues, the cellular and subcellular distribution of these complexes is largely unexplored. Using antibodies against ten mammalian septins, we show that septins diverge with respect to their tissue distribution implying that septin complexes in various tissues have unique composition. Although all ten septins examined were expressed in brain tissue, we describe septin complex(es) including SEPT3, SEPT5, SEPT6, SEPT7 and SEPT11 that could be functional within the presynapse because, unlike other septins they: (1) showed an increase in expression from embryonic day 15 to post-natal day 70, (2) were abundantly expressed in axons and growth cones of developing hippocampal neurons, (3) were found in presynaptic terminals of mature synapses, (4) were enriched in a preparation of synaptic vesicles and (5) immunoprecipitated together from brain tissue and cultured nerve cells. Knockdown of SEPT5 or SEPT7 in developing hippocampal neurons impaired axon growth. Because septins are functionally linked to the cytoskeleton and vesicle traffic, presynaptic neuronal septin complexes could be important for ensuring proper axon development and neurotransmitter release.
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An, Hanbing, Jennifer L. Morrell, Jennifer L. Jennings, Andrew J. Link, and Kathleen L. Gould. "Requirements of Fission Yeast Septins for Complex Formation, Localization, and Function." Molecular Biology of the Cell 15, no. 12 (December 2004): 5551–64. http://dx.doi.org/10.1091/mbc.e04-07-0640.

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Septins are GTP binding proteins important for cytokinesis in many eukaryotes. The Schizosaccaromyces pombe genome sequence predicts orthologues of four of five Saccharomyces cerevisiae septins involved in cytokinesis and these are named Spns1-4p. That spns1-4 are not essential genes permitted the application of a combined genetic and proteomics approach to determine their functional relationships. Our findings indicate that Spns1-4p are present throughout interphase as a diffusely localized ∼8.5S complex containing two copies of each septin linked together as a chain in the order Spn3p-Spn4p-Spn1p-Spn2p. Septin recruitment to the medial region of the cell is genetically separable from ring formation, and whereas it is normally restricted to mitosis, it can be promoted without activation of the mitotic cell cycle machinery. Coalescence into ring structures requires Spn1p and Spn4p associate with at least one other septin subunit and the expression of Mid2p that is normally restricted to mitosis. This study establishes the functional requirements for septin complex organization in vivo.
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Fliegauf, Manfred, Anja Kahle, Karsten Häffner, and Barbara Zieger. "Distinct localization of septin proteins to ciliary sub-compartments in airway epithelial cells." Biological Chemistry 395, no. 2 (February 1, 2014): 151–56. http://dx.doi.org/10.1515/hsz-2013-0252.

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Abstract Mucociliary clearance of the airways is accomplished by cilia-mediated laminar mucus flow along the planar epithelial surface. Maintenance of the highly specific architecture of the ciliated airway epithelium with columnar-shaped epithelial cells and tightening of the epithelial barrier is mainly attributed to the F-actin cytoskeleton. Recently, members of the highly conserved family of septin proteins have been shown to play crucial roles in ciliated tissue. These GTP-binding proteins form hetero-oligomeric complexes and assemble higher-order cytoskeletal structures such as filaments, bundles and ring-like structures such as a membrane diffusion barrier at the ciliary base. Here we analyzed the subcellular and sub-ciliary localization of various septin proteins by immunofluorescence imaging of airway epithelial cells. In addition to cytoplasmic localization we found that septins are either enriched at the apical cell cortex including the ciliary bases (septin-2, -4, -6, and -7), or show axonemal staining (septin-2, -7, -9 and -11) or specifically localize to ciliary sub-compartments (septin-8 and -9). The distinct localization of septins suggests structural functions as cytoskeletal components and as elements of the mechanical barrier at the apical cell cortex. Furthermore, the tight association of septin-8 and -9 with the ciliary compartment indicates a possible involvement in cilia-specific functions and cilia-related diseases.
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Shinoda, Tomoyasu, Hidenori Ito, Kaori Sudo, Ikuko Iwamoto, Rika Morishita, and Koh-ichi Nagata. "Septin 14 is involved in cortical neuronal migration via interaction with Septin 4." Neuroscience Research 68 (January 2010): e251. http://dx.doi.org/10.1016/j.neures.2010.07.1113.

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Casamayor, Antonio, and Michael Snyder. "Molecular Dissection of a Yeast Septin: Distinct Domains Are Required for Septin Interaction, Localization, and Function." Molecular and Cellular Biology 23, no. 8 (April 15, 2003): 2762–77. http://dx.doi.org/10.1128/mcb.23.8.2762-2777.2003.

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ABSTRACT The septins are a family of cytoskeletal proteins present in animal and fungal cells. They were first identified for their essential role in cytokinesis, but more recently, they have been found to play an important role in many cellular processes, including bud site selection, chitin deposition, cell compartmentalization, and exocytosis. Septin proteins self-associate into filamentous structures that, in yeast cells, form a cortical ring at the mother bud neck. Members of the septin family share common structural domains: a GTPase domain in the central region of the protein, a stretch of basic residues at the amino terminus, and a predicted coiled-coil domain at the carboxy terminus. We have studied the role of each domain in the Saccharomyces cerevisiae septin Cdc11 and found that the three domains are responsible for distinct and sometimes overlapping functions. All three domains are important for proper localization and function in cytokinesis and morphogenesis. The basic region was found to bind the phosphoinositides phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate. The coiled-coil domain is important for interaction with Cdc3 and Bem4. The GTPase domain is involved in Cdc11-septin interaction and targeting to the mother bud neck. Surprisingly, GTP binding appears to be dispensable for Cdc11 function, localization, and lipid binding. Thus, we find that septins are multifunctional proteins with specific domains involved in distinct molecular interactions required for assembly, localization, and function within the cell.
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Rios-Valencia, Diana G., Edgar O. López-Villegas, Dylan Diaz Chiguer, Adrian Marquez Navarro, Ruben D. Díaz-Martín, Benjamin Nogueda-Torres, and Javier R. Ambrosio. "In Vitro Analyses Reveal the Effect of Synthetic Cytokinin Forchlorfenuron (FCF) on a Septin-Like Protein of Taeniid Cysticerci." Journal of Parasitology Research 2019 (March 3, 2019): 1–11. http://dx.doi.org/10.1155/2019/8578936.

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Cytokinin forchlorfenuron (FCF), a synthetic cytokinin, has been used specifically for the characterization of septins. In spite of genomic evidence of their existence, nothing is known about septin filaments in taeniid cestodes. The aim of this work was to determine the presence of a septin-like protein in cysticerci of Taenia crassiceps and Taenia solium using the deduced amino acid sequence of T. solium septin 4 (SEPT4_Tsm), to design and synthesize a derived immunogenic peptide (residues 88 to 103), to prepare a specific rabbit polyclonal antibody, and to examine the effects of FCF at different concentrations and exposure times on an in vitro culture of T. crassiceps cysticerci. In vitro, FCF altered the morphology and motility of T. crassiceps cysticerci, and its effects were reversible under specific concentrations. In addition, we observed by ultrastructural observation that FCF alters the cellular subunit of the protonephridial system of cestodes, where disruption of the axoneme pattern of flame cells was observed. The rabbit polyclonal antibody prepared against the synthetic peptide recognized a major band of 41 kDa in both parasites. Our results establish the importance of SEPT4_Tsm in the dynamics and survival of taeniid cysticerci, as well as their susceptibility to FCF. This is also the first report that a septin is present in the cytoskeleton of taeniids.
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Wasik, Anita A., Zydrune Polianskyte-Prause, Meng-Qiu Dong, Andrey S. Shaw, John R. Yates, Marilyn G. Farquhar, and Sanna Lehtonen. "Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking." Molecular Biology of the Cell 23, no. 17 (September 2012): 3370–79. http://dx.doi.org/10.1091/mbc.e11-12-1010.

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Podocytes are insulin-sensitive and take up glucose in response to insulin. This requires nephrin, which interacts with vesicle-associated membrane protein 2 (VAMP2) on GLUT4 storage vesicles (GSVs) and facilitates their fusion with the plasma membrane. In this paper, we show that the filament-forming GTPase septin 7 is expressed in podocytes and associates with CD2-associated protein (CD2AP) and nephrin, both essential for glomerular ultrafiltration. In addition, septin 7 coimmunoprecipitates with VAMP2. Subcellular fractionation of cultured podocytes revealed that septin 7 is found in both cytoplasmic and membrane fractions, and immunofluorescence microscopy showed that septin 7 is expressed in a filamentous pattern and is also found on vesicles and the plasma membrane. The filamentous localization of septin 7 depends on CD2AP and intact actin organization. A 2-deoxy-d-glucose uptake assay indicates that depletion of septin 7 by small interfering RNA or alteration of septin assembly by forchlorfenuron facilitates glucose uptake into cells and further, knockdown of septin 7 increased the interaction of VAMP2 with nephrin and syntaxin 4. The data indicate that septin 7 hinders GSV trafficking and further, the interaction of septin 7 with nephrin in glomeruli suggests that septin 7 may participate in the regulation of glucose transport in podocytes.
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Valadares, Napoleão Fonseca, Humberto d’ Muniz Pereira, Ana Paula Ulian Araujo, and Richard Charles Garratt. "Septin structure and filament assembly." Biophysical Reviews 9, no. 5 (September 13, 2017): 481–500. http://dx.doi.org/10.1007/s12551-017-0320-4.

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Dissertations / Theses on the topic "Septin 4"

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Silva, Nayara Cavalcante. "Estudos das interações da septina 4 humana." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-16092009-150319/.

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Septinas são proteínas ligantes a GTP encontradas desde fungos até metazoários. A primeira função identificada para septinas foi o seu papel central na organização e dinâmica do septo de divisão de leveduras. Uma das características marcantes é que septinas se organizam em heterofilamentos de 7 a 9 nm de espessura que foram purificados de diversos organismos tais como Saccharomyces cerevisiae, Drosophila e cérebro de camundongos. Hoje se sabe que septinas não estão envolvidas apenas nos processos de divisão celular, mas em uma variedade de processos como tráfico de vesículas, exocitose, interação com proteínas do citoesqueleto e com a membrana plasmática, o que resulta em alterações da morfologia celular. Neste trabalho foram desenvolvidos estudos da septina 4 humana (SEPT4) nos quais foi realizado a expressão e purificação da SEPT4 pelo uso do sistema de expressão heteróloga em E. coli e em células de insetos (Sf-9) via baculovírus. A tentativa de expressão usando o vetor pETTEV em E.coli não obteve sucesso, pois a proteína não foi expressa na forma solúvel. A construção do baculovírus recombinante AcSept4 e expressão da SEPT4 nas células de insetos foi realizada com êxito, mas o processo de purificação não foi satisfatório. Com o intuito de obter informações sobre possíveis proteínas que interagem com a SEPT4 e conseqüentemente sobre as funções desempenhadas por ela na célula, a SEPT4 foi utilizada como isca para ensaios de interação proteína-proteína pela técnica de duplo híbrido. Para isso, o gene da SEPT4 foi clonado fusionado ao domínio de ligação ao DNA Lex-A. A realização do ensaio de duplo híbrido com a proteína completa não foi possível, pois a mesma provocou a auto ativação do sistema, por isso uma nova construção foi realizada com a região GTPase e C-terminal SEPT4GC (124-478) como isca. Dentre as interações identificadas, foram encontradas apenas septinas do grupo II (SEPT6, SEPT8, SEPT10 e SEPT11) e quatro novas interações, que ainda precisam ser confirmadas. Por outro lado, uma interação já descrita na literatura envolve a proteína α-sinucleína, que é uma proteína abundantemente expressa no cérebro e associada à doença de Parkinson. O foco do estudo dessa interação foi realizar ensaios com os diferentes domínios da SEPT4 para comprovar uma interação direta e com isso tentar mapear o sítio de interação com a α-sinucleína. Os resultados obtidos pela ressonância plasmônica de superfície (SPR) indicam que o domínio C-terminal participa da interação com baixa afinidade (K,D=390 µM) e sugerem que o domínio GTPase também pode estar envolvido. Já os dados obtidos com os experimentos de RMN e anisotropia de fluorescência mostram indícios que a interação é dependente da conformação da α-sinucleína por que a interação aconteceria com maior afinidade quando a α-sinucleína está na presença de SDS.
Septins are a family of GTP binding proteins found in a great diversity of organisms. These proteins have been identified as having a central role in septum organization during yeast division. Septins are organized into heterofilaments which are 7 to 9 nm wide and these have been purified from yeast, Drosophila and mice brain. Septins are not only required for cell division, but seem to play a role also in vesicle trafficking and in the formation of diffusion barriers within cells, since they interact with cytoskeleton proteins and the plasma membrane causing changes in cell morphology. In the present work, the aim was investigate human Septin 4 (SEPT4), a septin highly expressed in the brain. One objective of this work was to find a suitable expression system and purification method for SEPT4. The protein was expressed in both E.coli and insect cells (Sf-9). Expression in E. coli with the vector pETTEV was unsuccessful because the protein was insoluble. Expression in insect cells using the recombinant baculovirus AcSept4, was obtained successfully, but the purification was difficult. Important information concerning SEPT4 function might be acquired, if interactions partners involved in cellular process were identified. With this goal in mind, a yeast two hybrid assays were performed. The sept4 gene was fused to the Lex-A DNA binding domain and used as bait in the yeast two hybrid essays. However, full length SEPT4 showed autonomous activation of reporter genes. A second construct was prepared including only GTPase domain and the carboxy terminus domain, (residues 124 to 478) and the screen of interactions were carried out only with SEPT4GC. All of the group II septins (SEPT6, SEPT8, SEPT10 and SEPT11) were identified together with four new interactions. The latter still need be confirmed. In addition, another interaction already described in the literature is between SEPT4 and α-synuclein, which is a protein highly expressed in brain and related to Parkinson\'s disease. Different spectroscopic methods and SPR were used to identify which domain of SEPT4 interacts directly with α-synuclein and in which region. The surface plasmon resonance (SPR) results indicate that the carboxy terminus participates in the interaction with low affinity (KD = 390 µM) and suggests that the GTPase domain may also be involved. The results obtained by fluorescence anisotropy and NMR studies provide evidence that the interaction is dependent on the α-synuclein conformation, because the affinity of SEPT4 and α-synuclein seemed to be higher in the presence of SDS.
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Muñoz, i. Soriano Verònica. "Caracterización de Septin 4, un gen que codifica un potencial sustrato de Parkin en Drosophila." Universitat de València, 2008. http://www.tesisenxarxa.net.

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Voss, Söhnke. "Molecular investigations of agonists and antagonists of Toll-like receptors 2 and 4." [S.l. : s.n.], 2006.

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Mewes, Caspar Niclas [Verfasser]. "Einfluss genetischer Varianten aus dem CTLA-4-Gen auf den Krankheitsverlauf von Patienten mit Sepsis / Caspar Niclas Mewes." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://nbn-resolving.de/urn:nbn:de:gbv:7-21.11130/00-1735-0000-0008-58E7-1-9.

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Berthet, Julien. "Rôle fonctionnel du Toll-Like Receptor 4 exprimé par les plaquettes sanguines en tant que cellules inflammatoires de l'immunité." Phd thesis, Université Jean Monnet - Saint-Etienne, 2010. http://tel.archives-ouvertes.fr/tel-00673243.

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Les plaquettes jouent un rôle majeur dans l'hémostase primaire ainsi que dans l'inflammation. Elles contiennent et sécrètent une grande variété de facteurs solubles et parmi les nombreux récepteurs qu'elles expriment à leur surface, les plaquettes expriment les " Toll-Like Receptor " (TLR), récepteurs clés de l'interaction entre l'immunité innée et adaptative. En réponse à un stimulus infectieux, comme le lipopolysaccharide (LPS) des bactéries Gram-négative, ligand naturel du TLR4, ou des peptides issus d'une partie de la protéine d'enveloppe du VIH (gp41), les plaquettes vont s'activer de manière différentielle. L'activation plaquettaire est variable en fonction de leur activation par à un stimulus hémostatique (exemple : la thrombine) vs. infectieux (exemple : le LPS) ; le panel de cytokines libérées dans le surnageant plaquettaire semble en fait finement régulé. De plus, nous avons démontré la présence intra-plaquettaire de la majorité des protéines composant les voies de signalisation du TLR4 eucaryote. Nous avons ensuite montré que ces voies pouvaient être modulées. L'engagement du TLR4 plaquettaire par deux types biochimiques de LPS entraîne un relargage différentiel des facteurs solubles immunomodulateurs dans le surnageant de culture et que ce surnageant dernier génère une activation différentielle des cellules cibles, comme les cellules mononucléées du sang circulant. Ces travaux montrent que la réponse inflammatoire plaquettaire est régulée en fonction du stimulus. Ainsi, mes travaux s'inscrivent dans la ré-exploration de la fonction inflammatoire des plaquettes sanguines et l'étude du rôle des plaquettes comme cellules de l'immunité innée et inflammatoire
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Krause, Petra [Verfasser], Wolfram [Akademischer Betreuer] Keßler, Wolfram [Gutachter] Keßler, Sylvia [Gutachter] Stracke, and Matthias [Gutachter] Gründling. "Die Rolle des Chemokinrezeptors 4 in der polymikrobiellen murinen Sepsis / Petra Krause ; Gutachter: Wolfram Keßler, Sylvia Stracke, Matthias Gründling ; Betreuer: Wolfram Keßler." Greifswald : Universität Greifswald, 2019. http://d-nb.info/1194162754/34.

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Krause, Petra [Verfasser], Wolfram [Akademischer Betreuer] Keßler, Wolfram Gutachter] Keßler, Sylvia [Gutachter] [Stracke, and Matthias [Gutachter] Gründling. "Die Rolle des Chemokinrezeptors 4 in der polymikrobiellen murinen Sepsis / Petra Krause ; Gutachter: Wolfram Keßler, Sylvia Stracke, Matthias Gründling ; Betreuer: Wolfram Keßler." Greifswald : Universität Greifswald, 2019. http://nbn-resolving.de/urn:nbn:de:gbv:9-opus-29285.

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Van, der Linde Julia [Verfasser]. "Die Untersuchung der disseminierten intravasalen Koagulopathie am Mausmodell der polymikrobiellen Sepsis mit besonderer Berücksichtigung des CC-Chemokinrezeptors 4 auf Thrombozyten / Julia Van der Linde." Greifswald : Universitätsbibliothek Greifswald, 2013. http://d-nb.info/1034293737/34.

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Tamarkin, Andrey [Verfasser]. "Auftreten und Dynamik der Entwicklung von schwerer Sepsis und septischem Schock bei intensivstationären Patienten mit Polymorphismen der Toll-like-Rezeptoren 2 und 4 / Andrey Tamarkin." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1027306888/34.

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Venancio, Tatiana Martins. "A proteína de transferência de colesterol esterificado humana protege camundongos da sepse polimicrobiana e atenua a resposta inflamatória em macrófagos estimulados com lipopolissacarídeo." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-12052015-084007/.

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Sepse é a resposta inflamatória sistêmica decorrente de infecção grave, com alto índice de mortalidade, tornando-se um grave problema de saúde pública. Apesar dos inúmeros estudos realizados em busca de alternativas terapêuticas, o entendimento acerca dos mecanismos envolvidos na doença permanece restrito. A interação entre o metabolismo lipídico e a resposta inflamatória tem sido intensamente investigada. Neste estudo, avaliou-se a influência da proteína de transferência de colesterol esterificado (CETP) - glicoproteína plasmática que promove a transferência de lípides entre lipoproteínas - na resposta inflamatória. Inicialmente, foram comparados camundongos transgênicos para CETP humana (CETP) e controles irmãos não transgênicos (WT) submetidos ao modelo de sepse polimicrobiana de ligadura e perfuração do ceco (CLP), avaliando a taxa de sobrevida e o perfil inflamatório entre os grupos. Em seguida, a resposta inflamatória em macrófagos de peritônio de camundongos estimulados com LPS na ausência ou presença da CETP exógena (CETP humana recombinante) e endógena (macrófagos de animais CETP) foi analisada. Verificou-se que camundongos CETP apresentaram maior taxa de sobrevida, maior migração de linfócitos para o foco infeccioso, menores concentrações plasmáticas de IL-6 e menor expressão proteica do receptor Toll-like 4 (TLR4) e da enzima aciloxiacilo hidrolase (AOAH) no fígado, comparados aos WT. Nos macrófagos, observou-se que a presença da CETP recombinante foi capaz de se ligar ao LPS, pela análise da microscopia confocal, e, em cultura, reduziu de forma dose dependente a captação de LPS, a expressão de TLR4, a ativação do NF-kB (p65) e a secreção de IL-6 para o sobrenadante do cultivo celular. Os dados obtidos com os macrófagos de animais CETP corroboraram, em parte, os encontrados com a utilização da CETP exógena. Houve redução da captação de LPS e da ativação do NF-kB (p65), sem alteração na expressão de TLR4 e secreção de IL-6. Entretanto, apresentaram redução das concentrações de TNF-alfa celular e no sobrenadante de cultura. Dessa maneira, foi possível concluir que a CETP atua como agente modulador da resposta inflamatória induzida pela CLP e em macrófagos estimulados pelo LPS. Esses achados devem ser considerados nas doenças inflamatórias e nos futuros estudos relacionados à inibição da CETP, além de estabelecer novas perspectivas de tratamento da sepse
Sepsis is a systemic inflammatory response due to serious infection with high mortality rate, which has become a serious problem for public health. Despite numerous studies seeking for therapeutic alternatives, the understanding of the mechanisms involved in this disease remains limited. The interaction between lipid metabolism and inflammatory response has been intensively investigated. In the present study it was evaluated the influence of CETP (cholesteryl ester transfer protein) - plasma glycoprotein that promotes the transfer of lipids between lipoprotein - in the inflammatory response. Initially transgenic mice for human CETP (CETP) were compared to non transgenic control mice (WT) after polymicrobial sepsis induced by cecal ligation and puncture (CLP), to determine survival rate and the inflammatory profile between groups. Then, macrophages isolated from peritoneal cavity stimulated with LPS in the presence or absence of exogenous CETP (recombinant human CETP) and endogenous CETP (macrophages from CETP mice) were analyzed. It was found that CETP mice showed a higher survival rate, a greater lymphocyte migration to infectious focus, a lower IL-6 plasma concentration and a decrease in Toll-like receptor 4 (TLR4) and acyloxyacyl hydrolase enzyme (AOAH) protein expression in the liver in comparison to WT mice. In macrophages, recombinant CETP was able to bind to LPS, by confocal microscopy analysis and in cell culture, it was observed that in the presence of the recombinant CETP macrophages presented decreased in LPS uptake, TLR4 expression, NF-kB activation (p65) and IL-6 secretion into the cell culture medium. Furthermore, the results with macrophages from animals CETP corroborate partly with what was found in the exogenous experiments. LPS uptake and NF-kB activation (p65) were reduced, but no difference regarding the expression of TLR4, nor the IL-6 secretion to the cell culture medium. However, the CETP group also showed reduced levels of TNF-alfa both in macrophages and in the culture supernatant. Thus, we conclude that CETP acts as modulator of the inflammatory response induced by CLP and in the macrophages stimulated by LPS. In addition, new therapeutic perspectives could be established
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Books on the topic "Septin 4"

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Eichacker, Peter Q., and Jérôme Pugin, eds. Evolving Concepts in Sepsis and Septic Shock. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1581-4.

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Ortiz-Ruiz, Guillermo, Marco A. Perafán, Eugen Faist, and Carmelo Dueñas Castell, eds. Sepsis. New York, NY: Springer New York, 2006. http://dx.doi.org/10.1007/0-387-34574-4.

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Walker, Wendy E., ed. Sepsis. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1488-4.

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Pérez-Riera, Andrés R., Raimundo Barbosa-Barros, and Adrian Baranchuk. Left Septal Fascicular Block. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-27359-4.

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Baue, A. E., G. Berlot, A. Gullo, and J. L. Vincent, eds. Sepsis and Organ Dysfunction. Milano: Springer Milan, 2001. http://dx.doi.org/10.1007/978-88-470-2229-4.

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Lue, Hung-Chi, and Atsuyoshi Takao, eds. Subpulmonic Ventricular Septal Defect. Tokyo: Springer Japan, 1986. http://dx.doi.org/10.1007/978-4-431-68375-9.

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Heck, Eberhard, and Antonie Wlosok, eds. Lactantius: Divinarum institutionum libri septem. Fasc. 4: Liber VII. Appendix. Indices. Berlin, Boston: DE GRUYTER, 2011. http://dx.doi.org/10.1515/9783110262384.

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Schuster, Hans-Peter, ed. Intensivtherapie bei Sepsis und Multiorganversagen. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-662-07958-4.

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Schlag, Günther, Heinz Redl, and Daniel Traber, eds. Shock, Sepsis, and Organ Failure. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60698-4.

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Quinn, Peter J., and Xiaoyuan Wang. Endotoxins: Structure, function and recognition. Dordrecht: Springer Verlag, 2010.

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Book chapters on the topic "Septin 4"

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Rosmarin, Caryn. "Septic Arthritis." In Practical Clinical Microbiology and Infectious Diseases, 327–32. First edition. | Boca Raton : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9781315194080-4-57.

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Rosmarin, Caryn. "Septic Bursitis." In Practical Clinical Microbiology and Infectious Diseases, 333–35. First edition. | Boca Raton : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9781315194080-4-58.

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Lillie, Patrick. "Neutropaenic Sepsis." In Practical Clinical Microbiology and Infectious Diseases, 264–66. First edition. | Boca Raton : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9781315194080-4-40.

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Kurosawa, Hiromi, and Anton E. Becker. "Atrioventricular Septal Defect." In Atrioventricular Conduction in Congenital Heart Disease, 87–96. Tokyo: Springer Japan, 1987. http://dx.doi.org/10.1007/978-4-431-68045-1_3.

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Kurisu, Kazuhiro. "Atrial Septal Defect." In Cardiovascular Surgery for Congenital Heart Disease, 88–91. Tokyo: Springer Japan, 2009. http://dx.doi.org/10.1007/978-4-431-99470-1_14.

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Yasui, Hisataka. "Ventricular Septal Defect." In Cardiovascular Surgery for Congenital Heart Disease, 126–35. Tokyo: Springer Japan, 2009. http://dx.doi.org/10.1007/978-4-431-99470-1_19.

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Lue, Hung-Chi. "Is subpulmonic ventricular septal defect an Oriental disease?" In Subpulmonic Ventricular Septal Defect, 3–8. Tokyo: Springer Japan, 1986. http://dx.doi.org/10.1007/978-4-431-68375-9_1.

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Lue, Hung-Chi, Tseng-Chen Sung, Shou-Hsien Hou, Mei-Hwan Wu, Su-Ju Cheng, Shu-Hsung Chu, and Chi-Ren Hung. "Ventricular septal defect in Chinese with aortic valve prolapse and aortic regurgitation." In Subpulmonic Ventricular Septal Defect, 72–81. Tokyo: Springer Japan, 1986. http://dx.doi.org/10.1007/978-4-431-68375-9_10.

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Hung, Chi-Ren. "Surgery of ventricular septal defect with prolapse of aortic cusp." In Subpulmonic Ventricular Septal Defect, 85–89. Tokyo: Springer Japan, 1986. http://dx.doi.org/10.1007/978-4-431-68375-9_11.

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Van Mierop, Lodewyk H. S., and Lynn M. Kutsche. "Development of the ventricular septum of the heart." In Subpulmonic Ventricular Septal Defect, 11–19. Tokyo: Springer Japan, 1986. http://dx.doi.org/10.1007/978-4-431-68375-9_2.

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Conference papers on the topic "Septin 4"

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Kodrich, L., P. Porterie, O. Lago, G. Bergonzelli, B. Sassetti, and J. C. Sanchez avalos. "MINI PLASMINOGEN-LIKE MOLECULE IN SEPTIC PATIENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644693.

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We have previously described (Thromb.Res.44(6),1986) an altered relation Plasminogen (Pig)/α2~antiplasmin (APL) (Plg/APL<0.6) in the plasma of septic patients. A probable explanation of the mechanism whereby this alteration takes place would be the degradation of Pig to fragments of lower molecular weight due to the action of leukocyte elastase.In order to confirm this we studied 10 patients with sepsis, which did not have clinicalorlaboratory evidence of disseminated intravascular coagulation or septic shock, with positive blood cultures for bacterial germs .Elastase-α1proteinase inhibitor complexes were measured by an enzyme-linked immunosorbent assay (mean:510±181.9ug/l;normal range:86±28.5ug/l). Pig and APL functional activities were assayed by the amidolytic method; Pig: 40±8.9%; normal range: 100±20% .APL: 95±10.1% formal range 100+20%. Two different behaviors were observed in the plasma Pig of these patients with regard to their capacity to bind to Lysi-ne-Sepharose 4B.0n the basis of this observation the patients were divided into two group.Group A(4 patients) only presented Pig activity in fraction 1 (Pig without lysine binding sites : LBS). Group B (6 patients) presented Pig activity in fraction 1 and in fraction 2 (Pig with LBS).The normal controls presented Pig activity only in fraction 2. All the fractions which presented functional Pig activity also presented immunologic Pig activity and developed areas of lysis in heated fibrin plates after activation with urokinaseIt seems tenable the hypothesis that the action of the leukocyte elastase is responsible for the degradation of Pig and this modification in the molecule would give rise to a greater depuration thus explaining the marked drop of the plasmatic levels seen in septic patients.
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Sophie Morin and Suzelle Barrington and Joann Whalen. "A modified septic tank system to effectively manage agricultural wastewaters." In 2004, Ottawa, Canada August 1 - 4, 2004. St. Joseph, MI: American Society of Agricultural and Biological Engineers, 2004. http://dx.doi.org/10.13031/2013.16773.

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"Working Through the Trauma of the Holocaust in European Cinema of the 2000s (Hungary, Poland and Austria)." In Sept. 4-5, 2019 Bordeaux (France). Universal Researchers, 2019. http://dx.doi.org/10.17758/uruae6.uh09194004.

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"Integration of Information, Linguistic and Artistic Milieux of Education in the System of General Education with the Use of Music Computer Technologies." In Sept. 4-5, 2019 Bordeaux (France). Universal Researchers, 2019. http://dx.doi.org/10.17758/uruae6.uh09194007.

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"Japanese and South Korean Approaches to Overcoming Gender Inequality: A Comparative Analysis." In Sept. 4-5, 2019 Bordeaux (France). Universal Researchers, 2019. http://dx.doi.org/10.17758/uruae6.uh09194013.

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Penrose, Nicola, and Sally Knightly. "113 Improvements in sepsis care." In Leaders in Healthcare Conference, Poster Abstracts, 4–6 November 2019, Birmingham, UK. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/leader-2019-fmlm.113.

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Temel, F. Zeynep, Hayley McClintock, Christopher J. Payne, Isaac Wamala, Conor J. Walsh, Nikolay V. Vasilyev, and Robert J. Wood. "Pop-Up-Inspired Design of a Septal Anchor for a Ventricular Assist Device." In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3458.

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Heart failure (HF) is a serious condition in which the heart cannot pump sufficient blood to sustain the metabolic needs of the body. A common indication of failure is a low ejection fraction, or the volumetric proportion of blood ejected when the ventricle contracts. In end-stage HF, support from a ventricular assist device (VAD) can assume some or all of the heart’s pumping work, improving the ejection fraction and restoring normal circulation. VAD therapy options for end-stage right heart failure (RHF) are limited, with only a few FDA-approved devices available for mechanical circulatory support [1]. These devices are based on continuous flow impellers; and despite anticoagulation therapy, use of currently available VADs is associated with thrombogenic risk since the blood must contact artificial non-biologic surfaces. An implantable VAD for RHF based on soft robotic pulsatile assistance has previously been proposed [2]. This device is comprised of a contractile element that is anchored to the ventricular septum and the right ventricle (RV) free wall. The device is programmed to contract in synchrony with the native heart beat and assist in approximating the septum and free wall together in order to augment blood ejection (Fig. 1). Potential advantages of this approach include reduced risk of thrombosis, since there is no blood flow through the lumen of the device, and the possibility for minimally invasive deployment of the device under ultrasound guidance. A key component in this VAD concept is the anchoring mechanism that couples the contractile actuator to the ventricular septum. In this work, we report design, fabrication and testing of a new septal anchor design. We exploit the emerging technology of pop-up MEMS [3] in order to fabricate a collapsible anchoring mechanism. Origami-inspired engineering and pop-up MEMS manufacturing techniques have previously been used for developing disposable and low-cost medical tools and devices [4]. The pop-up anchor can be deployed into the left ventricle (LV) via a standard delivery sheath. We validate the load bearing ability of the anchor and demonstrate deployment in an ex vivo simulation.
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Tanaka, T., T. Itoh, T. Tsujinaka, M. Sakon, J. Kambayashi, and T. Mori. "AN EXPERIMENTAL MODEL TO STUDY INTERRELATIONSHIP BETWEEN HYPER-COAGULABLE STATE AND ORGAN FAILURE IN SEPSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644245.

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Disseminated intravascular coagulation (DIC) and multiple organ failure (MOF) are critical consequences of septic patients but the pathogenesis has not been fully elucidated yet, because of the complexities of clinical cases. Thereby, attempts were made to establish animal model with DIC & MOF without injecting endotoxin, bacteria or procoagulants into circulation, which may result in misleading conclusions. Twenty four male Japan albino rabbits were divided into the following 4 groups; [A]-ligation of bile duct and instillation of fecal suspension ( appr. 2 X 107 gram negative rods)into the proximal bile duct. [B]-ligation of bile duct and instillation of sterile saline. [C]-laparotomy alone. [D]-[A] receiving intravenous heparin (50u/kg/h). Citrated blood from femoral vein was collected before and 3,6,9 hours after the surgical procedure. After the last blood collectioh, animals were sacrificed and lungs, liver and kidneys were harvested for histological evaluation. During 9h observation period,.the rabbits were kept anesthetized with pentobarbiturate and were hydrated with 4ml/kg/h saline. All animals survived during the period. The following findings were obtained in [A]. Platelet count was gradually decreased (p<0.05) and significant leukopenia was noted at 9h (p<0.01). APTT and PT were significantly prolonged after 3h (p㌼0.01) after 6h. Plasma creatinine and bilirubin were significantly increased than those of [B] (p<0.01). The amount of endotoxin in circulating blood, determined by colorimetric assay, was significantly elevated up to 200pg/ml (p<0.01) . Histological examination revealed glomerular thrombi and focal necrosis of the liver. In [B], bilirubin was slightly elevated and PT was prolonged but much abnormal values were noted in [A]. Endotoxemia was not detected at all in [B]. In [D], the value of PT and fibrinogen was comparable to that of [B] and also the value of bilirubin and creatinine was close to that of [B]. Thus, we established sepsis model with reproducible hypercoagulable state and organ failure. The prevention of organ failure by heparin administration indicates that hypercoagulable state is common etiologic factor in occurrence of DIC and MOF in sepsis
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Segal, Jonathan, Guy Worley, Janindra Warusavitarne, Susan Clark, and Omar Faiz. "PTU-062 Systematic review: the management of early pouch-related septic complications in ulcerative colitis." In British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, Abstracts. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-bsgabstracts.403.

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Kaiser, Ryan Sohail, Satyabrata Roychowdhury, Mihir Sarkar, and MOUSUMINANDI Ghosh. "237 Ultrasound guided fluid resuscitation in pediatric septic shock: a randomized controlled trial." In RCPCH Conference Singapore. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/bmjpo-2021-rcpch.4.

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Reports on the topic "Septin 4"

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McDonagh, Marian, Andrea C. Skelly, Amy Hermesch, Ellen Tilden, Erika D. Brodt, Tracy Dana, Shaun Ramirez, et al. Cervical Ripening in the Outpatient Setting. Agency for Healthcare Research and Quality (AHRQ), March 2021. http://dx.doi.org/10.23970/ahrqepccer238.

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Objectives. To assess the comparative effectiveness and potential harms of cervical ripening in the outpatient setting (vs. inpatient, vs. other outpatient intervention) and of fetal surveillance when a prostaglandin is used for cervical ripening. Data sources. Electronic databases (Ovid® MEDLINE®, Embase®, CINAHL®, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews) to July 2020; reference lists; and a Federal Register notice. Review methods. Using predefined criteria and dual review, we selected randomized controlled trials (RCTs) and cohort studies of cervical ripening comparing prostaglandins and mechanical methods in outpatient versus inpatient settings; one outpatient method versus another (including placebo or expectant management); and different methods/protocols for fetal surveillance in cervical ripening using prostaglandins. When data from similar study designs, populations, and outcomes were available, random effects using profile likelihood meta-analyses were conducted. Inconsistency (using I2) and small sample size bias (publication bias, if ≥10 studies) were assessed. Strength of evidence (SOE) was assessed. All review methods followed Agency for Healthcare Research and Quality Evidence-based Practice Center methods guidance. Results. We included 30 RCTs and 10 cohort studies (73% fair quality) involving 9,618 women. The evidence is most applicable to women aged 25 to 30 years with singleton, vertex presentation and low-risk pregnancies. No studies on fetal surveillance were found. The frequency of cesarean delivery (2 RCTs, 4 cohort studies) or suspected neonatal sepsis (2 RCTs) was not significantly different using outpatient versus inpatient dinoprostone for cervical ripening (SOE: low). In comparisons of outpatient versus inpatient single-balloon catheters (3 RCTs, 2 cohort studies), differences between groups on cesarean delivery, birth trauma (e.g., cephalohematoma), and uterine infection were small and not statistically significant (SOE: low), and while shoulder dystocia occurred less frequently in the outpatient group (1 RCT; 3% vs. 11%), the difference was not statistically significant (SOE: low). In comparing outpatient catheters and inpatient dinoprostone (1 double-balloon and 1 single-balloon RCT), the difference between groups for both cesarean delivery and postpartum hemorrhage was small and not statistically significant (SOE: low). Evidence on other outcomes in these comparisons and for misoprostol, double-balloon catheters, and hygroscopic dilators was insufficient to draw conclusions. In head to head comparisons in the outpatient setting, the frequency of cesarean delivery was not significantly different between 2.5 mg and 5 mg dinoprostone gel, or latex and silicone single-balloon catheters (1 RCT each, SOE: low). Differences between prostaglandins and placebo for cervical ripening were small and not significantly different for cesarean delivery (12 RCTs), shoulder dystocia (3 RCTs), or uterine infection (7 RCTs) (SOE: low). These findings did not change according to the specific prostaglandin, route of administration, study quality, or gestational age. Small, nonsignificant differences in the frequency of cesarean delivery (6 RCTs) and uterine infection (3 RCTs) were also found between dinoprostone and either membrane sweeping or expectant management (SOE: low). These findings did not change according to the specific prostaglandin or study quality. Evidence on other comparisons (e.g., single-balloon catheter vs. dinoprostone) or other outcomes was insufficient. For all comparisons, there was insufficient evidence on other important outcomes such as perinatal mortality and time from admission to vaginal birth. Limitations of the evidence include the quantity, quality, and sample sizes of trials for specific interventions, particularly rare harm outcomes. Conclusions. In women with low-risk pregnancies, the risk of cesarean delivery and fetal, neonatal, or maternal harms using either dinoprostone or single-balloon catheters was not significantly different for cervical ripening in the outpatient versus inpatient setting, and similar when compared with placebo, expectant management, or membrane sweeping in the outpatient setting. This evidence is low strength, and future studies are needed to confirm these findings.
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