Academic literature on the topic 'Sequence Indicators'
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Journal articles on the topic "Sequence Indicators"
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Mao, Quan, and Yuechen Liu. "Post-Disaster Performance and Restoration Sequences of Interdependent Critical Infrastructure Systems Considering Various Socioeconomic Impacts." Sustainability 16, no. 15 (2024): 6609. http://dx.doi.org/10.3390/su16156609.
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The failures of interdependent critical infrastructure systems (CISs) caused by disasters could result in significant impacts on the economy and society of cities. Although existing studies have proposed several socioeconomic impact indicators of CIS failures, using these indicators as optimization objectives of restoration sequences, most of them only selected one indicator and failed to reveal their differences. This study aims to analyze the differences between various socioeconomic impact indicators in evaluating post-disaster CIS performance and to identify their effects on the optimized restoration sequences. To achieve this objective, this study simulates the failure propagation and recovery process of CISs, based on network modeling, and constructs six socioeconomic impact indicators for evaluating CIS performance and optimizing the restoration sequence. Then, this study analyzes the effects of different socioeconomic impact indicators by comparing the differences between post-disaster CIS performance, as well as the corresponding restoration sequence and recovery efficiency, among five groups. The results indicate that ignoring social impacts would significantly underestimate the consequences of CIS failures, and the restoration sequence aimed at minimizing social impact differs from other methods, with the recovery efficiency in regards to the social impact notably lower than that of the economic impact. This implies that evaluating the multidimensional social impacts is essential for accurately understanding the worst-case consequences of CIS failures with a bottom-line perspective.
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Lebedev, Ilya. "Adaptive Regression Model Construction Based on the Functional Quality Analysis of the Sequence Segment Processing." Informatics and Automation 24, no. 2 (2025): 363–94. https://doi.org/10.15622/ia.24.2.1.
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The article considers the problem of constructing an adaptive model aimed at improving the quality indicators of processing information sequences. In data processing techniques that have found application in many application areas, the applied analysis of observation objects is computationally resource-intensive and requires many iterations in case of changes in data properties. The article proposes a technique for selecting segments of an information sequence obtained in different ways, which differs in the use of the quality functional of regression models for processing subsequences. The sequences of observation objects received at the input of the model are divided by various specified segmentation algorithms. Pre-selected regression models are trained on each obtained segment and, depending on the obtained values of the calculated quality functional, the best models in terms of quality indicators are assigned to the segments. This allows us to form an aggregation model for data processing. Based on the experiment on model data and samples, the proposed technique is assessed. The values of the quality indicator MSE and MAE are obtained for different processing algorithms and with a different number of segments. The proposed method makes it possible to increase the MSE and MAE indicators by segmentation and assignment of regression models that have the best indicators on individual segments. The proposed solution is aimed at further improvement of ensemble methods. Its application allows to increase the efficiency of setting up basic algorithms in case of data property transformation and to improve the interpretability of results. The method can be used in developing models and methods for processing information sequences.
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Liu, Peng, Linfeng Wu, Yanzhong Wang, and Lize Guo. "Optimization Method for Assembly Sequence Evaluation Based on Assembly Cost and Ontology of Aviation Reducers." Applied Sciences 14, no. 12 (2024): 5116. http://dx.doi.org/10.3390/app14125116.
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An assembly sequence evaluation is one of the most important research directions of assembly sequence planning (ASP) for complex mechanical transmission products. Currently, aviation reducers lack a multi-perspective and multi-level evaluation of their assembly sequence. The existing evaluation indicators vary. The evaluation methods have low effectiveness and poor practicability. Therefore, a comprehensive multidimensional evaluation method for complex assembly sequences is proposed in this paper. A multidimensional comprehensive evaluation of the overall assembly quality and performance indices of aviation reducer products is realized. Firstly, the main factors affecting assembly sequence planning are considered: the attributes of the basic unit parts and the cost control of the assembly process. An evaluation index system of assembly sequence planning based on the two dimensions of assembly cost and ontology is constructed. Then, according to the multidimensional evaluation index, fuzzy evaluation theory is used to establish a fuzzy set and a matrix for each dimensional evaluation index. The index weight is divided. A comprehensive evaluation model and the function of each dimension are established. After a comprehensive evaluation, the multidimensional assembly sequence evaluation method for aviation reducers is formed. Finally, the method is applied to the assembly process of the primary reducer of a helicopter’s main reducer, and a comprehensive evaluation of its assembly sequence scheme is completed to verify the feasibility of the proposed method. This article constructs a complex assembly sequence evaluation method that includes 12 evaluation indicators, improves the assembly sequence planning evaluation index system of aviation reducers, and can effectively promote the progress of optimization technology for complex assembly sequences of aviation reducers.
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Newton, Ryan J., Jessica L. VandeWalle, Mark A. Borchardt, Marc H. Gorelick, and Sandra L. McLellan. "Lachnospiraceae and Bacteroidales Alternative Fecal Indicators Reveal Chronic Human Sewage Contamination in an Urban Harbor." Applied and Environmental Microbiology 77, no. 19 (2011): 6972–81. http://dx.doi.org/10.1128/aem.05480-11.
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ABSTRACTThe complexity of fecal microbial communities and overlap among human and other animal sources have made it difficult to identify source-specific fecal indicator bacteria. However, the advent of next-generation sequencing technologies now provides increased sequencing power to resolve microbial community composition within and among environments. These data can be mined for information on source-specific phylotypes and/or assemblages of phylotypes (i.e., microbial signatures). We report the development of a new genetic marker for human fecal contamination identified through microbial pyrotag sequence analysis of the V6 region of the 16S rRNA gene. Sequence analysis of 37 sewage samples and comparison with database sequences revealed a human-associated phylotype within theLachnospiraceaefamily, which was closely related to the genusBlautia. This phylotype, termed Lachno2, was on average the second most abundant fecal bacterial phylotype in sewage influent samples from Milwaukee, WI. We developed a quantitative PCR (qPCR) assay for Lachno2 and used it along with the qPCR-based assays for humanBacteroidales(based on the HF183 genetic marker), totalBacteroidalesspp., and enterococci and the conventionalEscherichia coliand enterococci plate count assays to examine the prevalence of fecal and human fecal pollution in Milwaukee's harbor. Both the conventional fecal indicators and the human-associated indicators revealed chronic fecal pollution in the harbor, with significant increases following heavy rain events and combined sewer overflows. The two human-associated genetic marker abundances were tightly correlated in the harbor, a strong indication they target the same source (i.e., human sewage). Human adenoviruses were routinely detected under all conditions in the harbor, and the probability of their occurrence increased by 154% for every 10-fold increase in the human indicator concentration. Both Lachno2 and humanBacteroidalesincreased specificity to detect sewage compared to general indicators, and the relationship to a human pathogen group suggests that the use of these alternative indicators will improve assessments for human health risks in urban waters.
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Tverdokhlebov, V. A. "Models of Functional Dependencies of Elements in Sequences for Solving Problems of Control and Management." Mekhatronika, Avtomatizatsiya, Upravlenie 20, no. 10 (2019): 579–88. http://dx.doi.org/10.17587/mau.20.579-588.
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In paper developed version of the basic concepts, models and methods for the formulation and solution of problems of control and diagnosing of processes in systems, tasks of constructing models of processes in which the causal relationships of events are transformed into functional dependencies between elements in sequences, problems of formalizing of process control rules, etc. For this extended classical recurrent definition of the sequences, which presents the functional elements depending on the immediately preceding to them m elements to offered Z-recurrent definition, which defines the functional relationship between sets of elements in the sequence. The orders of Z-recurrent forms have the form of a set of numbers and are convenient for accurate and complete characterization of the connections of events in processes. The tasks of control, diagnosing, constructing new models of processes, assessing the complexity of processes and rules for managing processes can be formulated and solved using numerical indicators of Z-recurrent definitions. A classification of Z-recurrent definitions of sequences and a classification of processes are constructed, an algorithm for checking the feasibility of determining a Z-recurrent form for given sequences of form is developed. The Z-recurrent definition of sequence is complemented by the Z-recurrent sequence pattern method, which includes: introducing a linear order on the base set of sequence elements, constructing an image for the sequence in the form of a sequence of executing or non-executing relationships between the elements represented by a linear order, and applying Z-recurrent definitions to the constructed image of the sequence. The problem on which the solution of the considered problems is based is the recognition of two sequences by properties, which are determined by the indicators of Z-recurrent definitions of sequences, which have the form of orders of Z-recurrent forms. Sets of orders in executing or non-executing Z-recurrent forms characterize the sequences and the analyzed sets of sequences, which allows you to set and solve problems related to system management: problems of control and diagnosing of processes in the system, problems of constructing process models, problems of formalizing and complexity estimation of control rules of processes.
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Bogachek, Naum L. "ANALYTICAL SYSTEM FOR DEVELOPING AND TESTING PREDICTIVE SCENARIOS OF OPERATIONS WITH MARKETING TOOLS." EKONOMIKA I UPRAVLENIE: PROBLEMY, RESHENIYA 3/3, no. 156 (2025): 88–95. https://doi.org/10.36871/ek.up.p.r.2025.03.03.011.
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The article is devoted to the analytical system of development and testing of forecast scenarios of operations with marketing tools, which is the most important component of the digital information environment of the marketing system in business project management. The presented system provides economic analysis of operations with marketing tools based on signals of technical indicators. In the article on an example of operations with partner marketing investment bonuses Elmed Bonus H the application of indicator MACD is considered, profitability of sequence of operations on the basis of signals of the indicator is calculated, the comparative analysis with the forecast scenario within the limits of strategy buy-hold is carried out, results of testing of the indicator are presented, the optimum sequence of operations with marketing instruments is defined, the financial result is calculated. The conducted research allowed to draw conclusions about the importance of the analytical system of development and testing of forecast scenarios in increasing the efficiency of business project management and about the application of technical indicators in the marketing system.
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Mohan, A., S. Wedemeyer, S. Pandit, M. Saberi, and P. H. Hauschildt. "EMISSA (Exploring Millimeter Indicators of Solar-Stellar Activity)." Astronomy & Astrophysics 655 (November 2021): A113. http://dx.doi.org/10.1051/0004-6361/202142095.
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Context. Due to their wide wavelength coverage across the millimeter to centimeter (mm–cm) range and their increased sensitivity, modern interferometric arrays facilitate observations of the thermal and non-thermal radiation that is emitted from different layers in the outer atmospheres of stars. Aims. We study the spectral energy distribution (Sobs(ν)) of main-sequence stars based on archival observations in the mm–cm range with the aim to study their atmospheric stratification as a function of stellar type. Methods. The main-sequence stars with significant detection in mm bands were identified in the ALMA Science Archive. These data were then complemented with spectral flux data in the extreme ultraviolet to cm range as compiled from various catalogues and observatory archives. We compared the resultant Sobs(ν) of each star with a photospheric emission model (Smod(ν)) calculated with the PHOENIX code. The departures of Sobs(ν) from Smod(ν) were quantified in terms of a spectral flux excess parameter (ΔS∕Smod) and studied as a function of stellar type. Results. The initial sample consists of 12 main-sequence stars across a broad range of spectral types from A1 to M3.5 and the Sun-as-a-star as reference. The stars with Teff = 3000–7000 K (F–M type) showed a systematically higher Sobs(ν) than Smod(ν) in the mm–cm range. Their ΔS∕Smod exhibits a monotonic rise with decreasing frequency. The steepness of this rise is higher for cooler stars in the Teff = 3000–7000 K range, although the single fully convective star (Teff ~ 3000 K) in the sample deviates from this trend. Meanwhile, Sobs(ν) of the A-type stars agrees with Smod(ν) within errors. Conclusions. The systematically high ΔS∕Smod in F–M stars indicates hotter upper atmospheric layers, that is, a chromosphere and corona in these stars, like for the Sun. The mm–cm ΔS∕Smod spectrum offers a way to estimate the efficiency of the heating mechanisms across various outer atmospheric layers in main-sequence stars, and thereby to understand their structure and activity. We emphasise the need for dedicated surveys of main-sequence stars in the mm–cm range.
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Sumarni, Sri, and Farah Salsabila. "THE INFUSION OF CRITICAL THINKING SKILLS INDICATORS AND MICROLEARNING PRINCIPLES IN THE ENGLISH READING Materials for Vocational School Students: A Content Analysis." English Review: Journal of English Education 11, no. 3 (2023): 699–708. http://dx.doi.org/10.25134/erjee.v11i3.8819.
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This study aims to reveal the critical thinking skills indicators and microlearning features integrated in the English reading materials for vocational school students in Indonesia. A content analysis was employed to examine reading materials available in the English Coursebook Work in Progress for SMA/SMK/MA Grade X published by the Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia 2022. The critical thinking skills analysis was meant to capture to what extend do the reading materials coverage signify to the lifelong learning, while the microlearning features investigation was meant to portray how the reading materials are presented to support self-directed learning. 8 critical thinking skills indicators proposed by Anderson and Krathwohl. (2001) were hired as the parameters in determining the integration of the critical thinking skills. Microlearning framework proposed by Allela (2021) were used to determine the reading lesson sequences, with which instructional methods associating each sequence. The results revealed that the reading materials for grade X are presented in 8 printed texts covered descriptive, recount, procedures, expository and narrative. These texts have potentially carried critical thinking skills indicators. The contexts are all pictures and instructions that have potentially presented 3 critical thinking skill indicators. The activities cover 15 comprehension activities and 4 beyond the comprehension activities; 7 Critical thinking indicators are potentially embedded in this part. The reading materials presentation, one set are clearly sequenced in the framework of microlearning covers pre-text, text, and post-text. While the other 7 sets sequenced text and post-text. The analysis indicated most of the critical thinking indicators integrated in the reading materials are under analysis and evaluation.
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Millan, Kelly M., and Susan R. Mikkelsen. "Sequence-selective biosensor for DNA based on electroactive hybridization indicators." Analytical Chemistry 65, no. 17 (1993): 2317–23. http://dx.doi.org/10.1021/ac00065a025.
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Guo, Wei, Han Qiu, Zimian Liu, Junhu Zhu, and Qingxian Wang. "An integrated model based on feedforward neural network and Taylor expansion for indicator correlation elimination." Intelligent Data Analysis 26, no. 3 (2022): 751–83. http://dx.doi.org/10.3233/ida-215955.
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Existing correlation processing strategies make up for the defect that most evaluation algorithms do not consider the independence between indicators. However, these solutions may change the indicator system’s internal connection, affecting the final evaluation result’s interpretability and accuracy. Besides, traditional independent analysis methods cannot accurately describe the complex multivariate correlation based on the linear relationship. Aimed at these problems, we propose an indicators correlation elimination algorithm based on the feedforward neural network and Taylor expansion (NNTE). Firstly, we propose a generalized n-power correlation and a feedforward neural network to express the relationship between indicators quantitatively. Secondly, the low-order Taylor expression expanded at every sample is pointed to eliminate nonlinear relationships. Finally, to control the expansions’ accuracy, the layer-by-layer stripping method is presented to reduce the dimensionality of the correlations among multiple indicators gradually. This procedure continues to iterate until there are all simple two-dimensional correlations, eliminating multiple variables’ correlations. To compare the elimination efficiency, the ranking accuracy is proposed to measure the distance of the resulting sequence to the benchmark sequence. Under Cleveland and KDD99 two datasets, the ranking accuracy of the NNTE method is 71.64% and 96.41%, respectively. Compared with other seven common elimination methods, our proposed method’s average increase is 13.67% and 25.13%, respectively.
Dissertations / Theses on the topic "Sequence Indicators"
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Smetanová, Lucie. "Evaluation of Arrival Sequencing at Arlanda Airport." Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-168100.
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This work presents an analysis of arrival sequencing at Stockholm Arlanda airport. Thesequencing of arrivals is very important part of air traffic control management and assuressafe space and time distancing of arriving aircraft. In this work we use historical flight datafrom Opensky Network database. The historical flight data contains the information about allthe arrivals of the year 2018. The aim of this work is to propose the key performanceindicators (KPIs) for evaluation of the arrival sequencing at Stockholm Arlanda airport. Thethree KPIs we are considering in this work are the minimum time to final, spacing deviationand sequence pressure. We choose data subsets of different size representing different trafficsituations. We visualize the results and summarize them in tables which assures better clarityfor the comparison of the same KPIs for different data subsets. In addition, we demonstratehow the proposed KPIs can be used for evaluation of optimization results from related study.We conclude that the proposed KPIs are very useful for analysis of the arrival aircraftsequencing and help to uncover inefficiencies within the terminal manoeuvring area (TMA).
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Abouessa, Ashour. "Sedimentological and ichnological characteristics of Dur At Tallah siliciclastic rock sequence, and their significance in the depositional environment interpretation of tidal-fluvial system (Upper Eocene, Sirt Basin, Libya)." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00985603.
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Dur At Talah sedimentary sequence, located at the southern side of the Sirt Basin in central Libya, is composed of 150 m thick of mainly siliciclastic rocks. The importance of this sequence is linked to the importance of the Sirt Basin as one of large hydrocarbon reservoirs in Libya. The sequence is also an excellent site for vertebrate fossils of Late Eocene, the age of the sequence. Previous studies, though very limited compared to the importance of this area, are focused on its paleontological content. Sedimentology received only scant attention before this project. This thesis is an outcrop based study in which the focus is given to the sedimentary and biogenic (trace fossils) structures, aiming at defining and interpreting depositional facies which building up the sequence. The study is mainly based on field data which are analyzed on the light of related published literature and on the comparison with modern sedimentary environments. Results of facies analysis have led to splitting the entire sequence into three genetically related intervals. The oldest, we called the New Idam Unit (around 80m), is composed of very fine sandstones to mudstones. New Idam Unit is unconformably overlain by the Sarir Unit (around 50m), composed of medium grained cross bedded sandstones (the lower 25-30 m) changes up to very coarse and microconglomeratic sandstone (the upper 20-30 m). Thus, the Sarir Unit is split into the lower Sarir Subunit and upper Sarir subunit. The New Idam Unit presents both classical and unusual sedimentary and biogenic indicators that attribute this unit to estuarine depositional environment. It starts with outer estuarine (the lower 35 m) and ends up with inner estuarine (the upper 45 m). Maximum flooding surface is located in between. Above this surface the fluvial indicators increase and tidal indicators decrease, thus providing clue for basinward (North) migration of the shoreline. The lower Sarir subunit which was previously interpreted as fluvial deposits, preserves multi-scale sedimentary structures that undoubtedly belong to tidal processes. This is especially evidenced at the lower part of the lower Sarir Subunit (LLS). Fluvial indications over dominates the tidal ones in the upper part of the lower Sarir (ULS). Due to this configuration the whole lower Sarir subunit is interpreted as shallow marine, deltaic, depositional system, occurred during sea level ¨normal¨ regression. This time, maximum flooding surface is located between the LLS and ULS. The lower Sarir subunit is terminated by subaerial unconformity, with evidences of subaerial exposure preserved at the top of the ULS. These are intruded by the upper Sarir subunit which presents clear evidences of strictly fluvial environment of deposition. The deposits of the upper Sarir subunit record the low stand system tract part of the Dur At Talah sequence. In addition to the outlined results, the sequential pattern of the depositional events is suggested for the entire sequence of Dur At Talah. This study provides a valuable information regarding the depositional and sequential aspects of the Sirt Basin during the late Eocene, it also provide an unique case study for the better understanding of the shallow marine tidal deposits.
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Ghezzi, Jessique L. "INFLUENCE OF CLAY MINERALOGY ON SOIL DISPERSION BEHAVIOR AND WATER QUALITY." DigitalCommons@CalPoly, 2010. https://digitalcommons.calpoly.edu/theses/289.
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Currently, there is very little research available on nonpoint source pollution from rural watersheds. Government regulatory agencies are desperate for information regarding the causes of nonpoint source pollution, which includes the relationship between suspended soil particles and dispersion. Since soil dispersion is dependent on clay mineralogy, knowing the clay mineralogy of the soil in an area can help predict sediment loads entering the surrounding surface waters. This information is necessary to protect the resource value of our rivers, lakes, and estuaries, as well as to protect recreational activities such as fishing or hunting; but most importantly, this information is necessary to ensure the safety of our drinking water supply. Clay mineralogy and its influence on dispersion, as well as dispersion and its relation to water quality are the focus of this study. Soil mineralogy affects water quality in several ways: soil mineralogy determines the dispersivity of the clay portion of the soil and dispersive clays are likely to end up as suspended sediment in surface waters; weathering reactions contribute elements to water as dissolved load, and the sorption properties of clay minerals contribute to soils' ability to filter and carry pollutants. Through the use of X-ray diffraction, dispersivity, atomic absorption spectrometry, cation exchange capacity, and petrographic microscopy, this study shows that the clay mineral fraction of a soil determines the dispersivity, and that dispersed clay minerals contribute excess nutrients and metals as nonpoint source pollutants to surface waters.
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Udgata, Devi Bhagabati Prasad. "Glauconite as an indicator of sequence stratigraphic packages in a Lower Paleocene passive-margin shelf succession, Central Alabama." Auburn, Ala., 2007. http://repo.lib.auburn.edu/07M%20Theses/UDGATA_DEVI_55.pdf.
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Lewis, Margareta. "The idiom principle in L2 English : assessing elusive formulaic sequences as indicators of idiomaticity, fluency, and proficiency /." Stockholm : Department of English, Stockholm University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7317.
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Hallström, Per, and Per Dellrup. "Improving WiFi positioning through the use of successive in-sequence signal strength samples." Thesis, Växjö University, School of Mathematics and Systems Engineering, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-590.
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<p>As portable computers and wireless networks are becoming ubiquitous, it is natural to consider the user’s position as yet another aspect to take into account when providing services that are tailored to meet the needs of the consumers. Location aware systems could guide persons through buildings, to a particular bookshelf in a library or assist in a vast variety of other applications that can benefit from knowing the user’s position.</p><p>In indoor positioning systems, the most commonly used method for determining the location is to collect samples of the strength of the received signal from each base station that is audible at the client’s position and then pass the signal strength data on to a positioning server that has been previously fed with example signal strength data from a set of reference points where the position is known. From this set of reference points, the positioning server can interpolate the client’s current location by comparing the signal strength data it has collected with the signal strength data associated with every reference point.</p><p>Our work proposes the use of multiple successive received signal strength samples in order to capture periodic signal strength variations that are the result of effects such as multi-path propagation, reflections and other types of radio interference. We believe that, by capturing these variations, it is possible to more easily identify a particular point; this is due to the fact that the signal strength fluctuations should be rather constant at every position, since they are the result of for example reflections on the fixed surfaces of the building’s interior.</p><p>For the purpose of investigating our assumptions, we conducted measurements at a site at Växjö university, where we collected signal strength samples at known points. With the data collected, we performed two different experiments: one with a neural network and one where the k-nearest-neighbor method was used for position approximation. For each of the methods, we performed the same set of tests with single signal strength samples and with multiple successive signal strength samples, to evaluate their respective performances.</p><p>We concluded that the k-nearest-neighbor method does not seem to benefit from multiple successive signal strength samples, at least not in our setup, compared to when using single signal strength samples. However, the neural network performed about 17% better when multiple successive signal strength samples were used.</p>
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Strothmeyer, Anna-Maria [Verfasser], and Hendrik [Akademischer Betreuer] Veelken. "Comparative analysis of predicted HLA-binding of immunoglobulin idiotype sequences indicates T-cell mediated immunosurveillance in follicular lymphoma = Hinweise für eine T-Zell-vermittelte Immunosurveillance im Follikulären Lymphom." Freiburg : Universität, 2011. http://d-nb.info/1123462968/34.
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Vettori, Gregorio. "Scala delle distanze in astrofisica." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21197/.
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In astrofisica la determinazione delle distanze ha sempre assunto un ruolo molto importante, poiché essa consente una più accurata comprensione della struttura e dell’evoluzione dell’universo in cui ci troviamo. Ci sono molti metodi che possono essere seguiti, a seconda degli oggetti di studio e dello scopo della ricerca. I metodi diretti (geometrici), utilizzabili solo nei dintorni del Sistema Solare, permettono di calibrare quelli indiretti (indicatori primari e secondari), i quali sono utilizzabili a distanze molto maggiori. Ogni metodo consente di accurare il successivo, creando così un meccanismo di misura chiamato scala delle distanze cosmiche, la quale ha come fine ultimo la calibrazione della legge di Hubble, di fondamentale importanza in cosmologia.
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BarrientosCastillo, Fabiola Maria, and 巴莉安. "Disclosure Sequence of GRI Environmental Indicators of Contractors." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/69w3v9.
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碩士<br>國立成功大學<br>土木工程學系<br>106<br>Sustainability and corporate social responsibility (CSR) reporting have become an increasingly high profile issue in many countries and companies in recent years. However, disclosure completeness in CSR reports is not assured because information is not disclosed adequately by companies.
This study aims to find a disclosure sequence of Global Reporting Initiative (GRI) environmental indicators for contractors. The 34 indicators’ requirements and documentation sources were analyzed. The indicators were categorized into input-process-output stages, and three generations. Three studies of indicators disclosure were reviewed to know which indicators were more disclosed. The ISO 14031 data sources were used to categorize the indicators. Each data source was assigned an effort level to determine the priority of indicator disclosure.
The results show that 11 indicators related to materials, water, biodiversity, effluents and waste, product and services, supplier environment assessment, and environmental grievances mechanisms had lower data collection effort and should be disclosed first. The derivation rate was calculated to assess the independence of the indicators and found EN1 (material weight), EN30 (impact of transportation) and EN29 (monetary fines) had the highest rates. This study finally presents a sequence for disclosing indicators. EN 1 (material weight), EN3 (energy consumption), EN6 (reduction of energy), EN8 (water withdrawal), EN15 (direct GHG), EN16 (indirect GHG), EN22 (water discharge), and EN23 (weight of waste) are in the first priority for disclosure. The first priority indicators are found to be mostly related to construction. The indicators with first priority are also the first indicator from their aspects and their data can be used to disclose other indicators in those aspects.
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Li, Che-yu, and 李哲宇. "Indicator of The Randomness of A Binary Sequence." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/85085989070335179183.
Full textBooks on the topic "Sequence Indicators"
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Zemlyanskiy, Oleg. Evaluation activity. Business and asset valuation. INFRA-M Academic Publishing LLC., 2025. https://doi.org/10.12737/2170477.
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The textbook examines and explores, depending on the objectives of the assessment, the types of enterprise (business) value as an object of rights, a property complex and a method of obtaining income and other economic results, conditions, approaches and methods for determining the selected type of value of the assessed object. The article also examines the specifics of the origin, methods of commercialization and valuation of intellectual property objects, intangible assets, the functioning and interaction of intellectual property market entities. The content and essence of valuation activities, the theory of formation and methodology of determining the value of various objects, businesses, assets, intellectual property objects are revealed. The proposed methodology and methods for collecting, preparing and analyzing external and internal information that affects and is necessary for assessing the value of facilities and businesses allow us to prepare documentation for evaluation purposes, justify the choice and application of evaluation approaches and methods. It also provides elements of financial mathematics, methods for calculating various indicators, discusses the characteristics of approaches and methods, the sequence of assessing any type of business value, intangible assets for various purposes, including commercial turnover, increasing the efficiency and value of the business and its assets. Meets the requirements of the latest generation of federal state educational standards for higher education. It is intended for students of higher education programs in the fields of Economics, Management, and other areas of higher education, students, including additional professional education, graduate students, and teachers of these programs and areas. It can be useful for professional appraisers, employees of financial organizations, managers, specialists of enterprises and organizations doing business, and anyone who needs to know the value of a business, its assets, and an understanding of how to evaluate them.
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Casas, Arturo. Procesos da historiografía literaria galega Para un debate crítico. Fondazione Università Ca’ Foscari, 2021. http://dx.doi.org/10.30687/978-88-6969-530-8.
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Galician literary historiography shows links and ruptures that refer to the cultural history of Galicia itself and to the sequence of historical events that have delineated the social, economic and political development of the country since the nineteenth century. These coordinates comprise a series of processes, including the elaboration and propagation of ideologies aimed at achieving a way out of political subalternity and oriented towards the horizon of national emancipation. Those events and these processes also marked the connection of Galicia with modernity and the dynamics of historical change. As a result of the above, this book analyses critically the institutionalization processes of the history of Galician literature – with special emphasis on historiographic models such as that of Said Armesto, Carvalho Calero, Méndez Ferrín and others – and indicates the need to undertake a productive methodological innovation of the discipline in heuristic, organic and discursive terms. It further argues that this update should pay attention to substantive theoretical debates, not exclusively of specific cultural coordinates, such as Galician ones or any others that could be considered. Among these, the cooperation between history and sociology, the intellection of literary facts as historical facts, the review of the link between literary history and nation, the public uses of literary history, and the inquiry of discursive choices that promote a less self-indulgent and predictable historiography. This essentially involved a challenge, that of permanent dialogue with some of the most powerful critical reinterpretations of the Galician historiographic tradition and with alternative models constituted from feminist thought, postcolonial theories, the sociology of the literary field or the systemic theories of culture, as well as with the contributions made from a post-national understanding of the literary phenomenon.
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Hooghe, Liesbet, Gary Mark, Tobias Lenz, Jeanine Bezuijen, Besir Ceka, and Svet Derderyan. International Authority: From Concept to Measure. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198724490.003.0001.
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Chapter One discusses the theoretical-conceptual underpinnings of the Measure of International Authority (MIA). In what respects, and to what extent, do international organizations exert legal rational authority? What powers do non-state actors have in international decision making and dispute settlement? To what extent, when, and how do states sacrifice the national veto in collective decision making? The chapter is structured in a sequence of five steps from the abstract to the particular: conceptualize authority; specify the concept as formal authority of international organizations; unfold in the dimensions of delegation and pooling; operationalize international organization (IO) composition and decision making in indicators that describe institutional alternatives that can be reliably assessed; explicate principles for scoring and adjudicating cases.
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Chen, Shudong. Four Quartets in the Light of the Chinese Jar. The Rowman & Littlefield Publishing Group, 2020. https://doi.org/10.5040/9781666989489.
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Four Quartets in the Light of the Chinese Jar discusses how Four Quartets should be explored afresh with a prosodic-philosophically sustained interdisciplinary and cross-cultural literary approach in ways as the often overlooked pivotal image of the Chinese jar so indicates in the great sequence; the pivotal image suggests the subtle but vital elixir from both “The ‘shores of Asia and the Edgware Road’ [which] are brought together as they had been brought together to The Waste Land.” With a steady focus on the function words-mediated and phonemes-facilitated, and “autochthonously” void-suggesting verbal transformation, the book shows how the verbal transformation, especially of the cases with “parts of speech” in the live context, makes Four Quartets truly a “rhythmical creation of [meaningful] beauty”; it demonstrates how the meaningful poetic beauty culminates in a quintessential state or being of poetry not merely being “poetic” particularly in terms of its prosodically sustained philosophical tenets, which are often so serendipitously transformed into “virtuoso mastery of verbal music.” As genuine poetry, the great sequence flows freely from inside out at once in accordance with and in spirt of any given rhythmical form or rhyming pattern.
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Rost, Christian, and Frank A. Flachskampf. Transoesophageal and intracardiac echocardiography. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199599639.003.0004.
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Transoesophageal echocardiography (TOE), a minimal-risk, semi-invasive imaging procedure is nowadays an indispensable part of routine echocardiography. It is mainly necessary and indicated: ◆ To analyse some structures insufficiently seen transthoracically, such as the left atrial appendage or the thoracic aorta. ◆ In situations that prohibit the use of conventional transthoracic windows, such as the patient undergoing cardiac surgery.As in transthoracic echocardiography (TTE), the TOE examination consists of a sequence of views defined by internal landmarks; unlike TTE, depending on the patient’s tolerance and the clinical question, not all of these have to be obtained in every examination. Important typical indications for TOE are the search for signs of endocarditis, the search for cardiogenic emboli, diagnosis of left atrial (appendage) thrombi before cardioversion, diagnosis of aortic dissection, characterization of mitral and aortic valve pathology especially in the context of surgical repair, intraoperative monitoring of left ventricular function, and monitoring of interventional cardiac procedures monitored.For some indications, intracardiac echocardiography has been found useful. This procedure involves insertion of a transducer-tipped catheter into the caval vein and advancement to the right heart, or intra-aortic placement. Applications are electrophysiological procedures, interventional closure of atrial septal defect, aortic stent placement, and others.
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Touber, Jetze. The Bible in the Political Fabric of the Dutch Republic, 1660–1710. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198805007.003.0005.
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Chapter 4 investigates the repercussions of biblical philology, including Spinoza’s, within ecclesiastical administration locally and regionally. The Public Church warded off the effects of biblical criticism by keeping God’s Word in the safe enclosure of the States’ Translation and credal documents. Nevertheless, within the clergy itself, individuals broke ranks and threatened to undo the hermeneutical concord. A sequence of protracted conflicts at various levels of ecclesiastical administration indicates the tensions that continuously undermined the aspirations to harmony. Biblical philology was only indirectly at play in Utrecht in the 1650s and 1660s, but it was central in the anti-Coccejan campaign in Friesland in the 1680s. The Frisian campaign in turn provoked a response from the minister Frederik van Leenhof, who became progressively more Spinozist. Van Leenhof’s example shows how humanist biblical philology and Spinozist hermeneutics could come together in the heart of the Reformed Church, leading to unexpected outcomes.
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Bateson, Patrick. Evolutionary Theory Evolving. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199377176.003.0004.
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The formation of new species was thought to result from a slow process of Darwinian evolution, but evidence indicates it can occur suddenly. The organism was thought to be passive, playing no role in evolution, but it can affect the evolution of its descendants because of its mobility, choices, control of the environment, and adaptability. Developmental processes were thought to be irrelevant to an understanding of evolution, but the enormous growth of epigenetics suggests that these processes can play an important role in evolutionary change. Acquired information can be passed to progeny without changing DNA sequences, and information can be inherited for a period in the absence of the initial environmental trigger. All this evidence suggests that evolutionary theory is evolving.
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Ірина Дмитрівна, Садов’як. CLINICAL MANAGEMENT OF PATIENTS WITH COVID-19. “LIVE” CLINICAL INSTRUCTION (2021). ДЕРЖАВНА НАУКОВА УСТАНОВА «НАУКОВО-ПРАКТИЧНИЙ ЦЕНТР ПРОФІЛАКТИЧНОЇ І КЛІНІЧНОЇ МЕДИЦИНИ», 2021. http://dx.doi.org/10.31612/covid.
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SUMMARY. In response to the challenges posed by the coronavirus (COVID-19) pandemic, Ukraine has undergone the necessary legislative changes, harmonized with international approaches, which in turn have led to significant changes in health care practices. The Law of Ukraine “On Amendments to Some Legislative Acts of Ukraine on Provision of Treatment of Coronavirus Disease (COVID-19)” № 539-IX, the Order of the Ministry of Health “On Approval of the Procedure for Prescribing and Using Medicines for the Treatment of Coronavirus Disease (COVID-19)” of 30.06.2020 № 1482, registered in the Ministry of Justice of Ukraine on July 08, 2020 for № 641/34924, establish the conditions of use of registered medicines according to the indications not specified in the instructions for medical use (off label), and unregistered medicines, recommended by the relevant official bodies outside Ukraine for the treatment of COVID-19. In pursuance of legislative acts, the Standard of Emergency Care “Coronavirus Disease (COVID-19)”, the Standards of Medical Care “Coronavirus Disease (COVID-19)”, the Standard of Pharmaceutical Care “Coronavirus Disease (COVID-19)”, the Protocol “Provision of medical care for the treatment of coronavirus disease (COVID-19)” were developed, approved and updated in accordance with the established procedure. At the same time, in order to assist the doctor and the patient in making a rational decision in different clinical situations, a clinical guideline “CLINICAL MANAGEMENT OF PATIENTS WITH COVID-19. “LIVE” CLINICAL INSTRUCTION” was developed – a document containing systematic provisions on medical and medico-social assistance, developed using the methodology of evidence-based medicine on the basis of reliability and proof confirmation. The basis of this clinical guideline is the WHO guideline “Clinical management of COVID-19: interim guidance” (27.05.2020), supplemented by the provisions of other WHO documents, as well as clinical guidelines of Great Britain, Belgium, USA and Australia. This guideline, as a living guideline, is a WHO innovation driven by the urgent need for global collaboration to provide reliable data and guidance emerging in the world as the result of numerous randomized clinical trials on COVID-19. The clinical guideline reflects the sequence of evidence on COVID-19 treatment in the world during a pandemic, on the basis of which the treatment strategy depending on the stage of the disease was formed and the decisions to include and exclude drugs in the protocol for COVID-19 treatment were justified, and will be further updated.
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Bilański, Piotr. Trypodendron laeve Eggers w Polsce na tle wybranych aspektów morfologicznych i genetycznych drwalników (Trypodendron spp., Coleoptera, Curculionidae, Scolytinae). Publishing House of the University of Agriculture in Krakow, 2019. http://dx.doi.org/10.15576/978-83-66602-38-0.
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In Poland, there are 4 species of the liypodendron genus: T lineaium Oliv., T domestkum L., T signature Fakir. and 7: laeve Egg. Trypodendron laeve is the leastknown of this group. Many factors had influence on the state of research on this species, including taxonomic aspects. Taking into account the unsatisfactory state of knowledge regarding the prevalence of T iaeve in Poland, as well as scarce information on the morphology of this species, research was undertaken to I) document the presence, including new sites, of T laeve in Poland and define, if possible, the habitat and trophic conditions that may affect its occurrence, as well as II) determinate suitability of biometric and genetic methods for correct identification of t laeve against the background of other ambrosia beetle species. Research on the occurrence of T laeve in Poland, was carried out on 143 areas located throughout the country, representing various environmental conditions, primarily such as species composition of tree stands, terrain, altitude (from 16 to 929 meters above sea level) and their location in relation to zoogeographic regions. The research material was obtained mainly using various types of traps for catching ambrosia beetles baited with pheromone. Only in a few cases when attacking the wood of trees, the imagines of ambrosia beetles were obtained without luring agents. The research was conducted in 2007-2016. From the insect individuals identified on the grounds of morphological traits as T lineatum, T laeve, T domesticum and T signatum, originating from selected locations in Poland, 3-11 specimens were collected, for which genetic analyses were performed based on the COI gene fragments obtained by PCR. The research included tests for following paramcter: s sequence similarity, phylogenetic, evolutionary divergence and genetic. structure. As a result of research on the occurrence of ambrosia beetles in Poland, a total of 44207 individuals belonging to four species were collected: T lineatutn, 7: laeve, T domesticum and T signatum, whose share was respectively: 49.2%, 31.4%; 19.1% and 0.3%. In Poland, 1: laeve's imagines were found in 124 out of 143 examined sites. The presence of L reeve has been documented for the first time in 14 zoogeographic regions. This species was commonly found on study areas located from 118 to 929 m above sea level. In Poland the tree species attacked by T Mate include Pinus sylvestris L. and Picea abies (L) H. Karst. In Poland, T laeve as a host plant prefers sylvestris and reaches the highest population densities in the stands of this species. The work presents the exact morphological characteristics of T laeve and indicates the most important features that distinguish it from the other Trypodendrun spp. occurring in Poland. It has also been shown that the best results in the determination of species of the liypodendron genus, regardless of their sex, can be obtained using phylogenetic analysis based on a fragment of the COI gene.
Book chapters on the topic "Sequence Indicators"
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Rey, J., R. Cubaynes, A. Qajoun, and C. Ruget. "Foraminifera Indicators of Systems Tracts and Global Unconformities." In Sequence Stratigraphy and Facies Associations. Blackwell Publishing Ltd., 2009. http://dx.doi.org/10.1002/9781444304015.ch7.
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Baasch, Benjamin, Judith Heusel, Alexander Lähns, Michael Roth, and Jörn Groos. "Spectral Characterization of the Rail Surface in Urban Environments Using in-Service Vehicles." In Lecture Notes in Mobility. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-85578-8_42.
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Abstract Rail monitoring using in-service vehicles enables the fast detection of surface defects, which are often responsible for high noise emission. In this paper a processing sequence is presented that converts axle box accelerations into rail condition indicators based on spectral characteristics of the rail surface. The methodology is exemplified with data acquired with a shunter locomotive operating at an inland harbour in the city of Braunschweig, Germany.
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De Pinto, Alessandro, Md Mofakkarul Islam, and Pamela Katic. "Food Security Under a Changing Climate: Exploring the Integration of Resilience in Research and Practice." In Resilience and Food Security in a Food Systems Context. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23535-1_7.
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AbstractClimate change poses significant risks to our food systems, thus jeopardising the food security of millions of people worldwide. The concept of resilience is increasingly being proposed as a framework to find solutions to these challenges. In this chapter, we assess how resilience has been integrated in discussions about climate change and food security by both academics and practitioners. We performed a targeted review of the academic literature on climate change, food security, and resilience and found that despite a growing body of literature on the subject, the pathways through which actions translate into resilience and then into food security remain unclear. An examination of a sample of projects implemented through the Adaptation Fund revealed that many good practices with potential for resilience-building are used but also that suitable indicators and methods to monitor and evaluate resilience and its outcomes are lacking. Based on our findings, we conclude that while the concept of resilience has accompanied and may have favoured a transition towards more integrated approaches and interventions in work related to climate change and food security, further efforts are needed to identify an efficient and rational sequence of interventions to improve food security in response to climate threats.
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Gauthier, Jacques-Antoine, and Gaëlle Aeby. "Life Trajectories as Products and Determinants of Social Vulnerability." In Withstanding Vulnerability throughout Adult Life. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-4567-0_18.
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AbstractThis chapter aims at uncovering the heuristic potential associated with analyzing family and occupational trajectories holistically for the study of social vulnerability. Empirically, sequence analysis shows that distinct and enduring structuring processes shape individual life courses. Long term historical processes contribute to standardize or to the contrary to diversify life trajectories. Institutional mechanisms based among others on gender differentiation lead to uneven participation in the labor market and in family life for women and men. The ways in which an individual trajectory unfolds in one social domain is influenced by the way it unfolds in another domain. Over their life course, individuals accumulate positive or negative life experiences closely linked to resources availability. For instance, the experience of parenthood can be simultaneously fulfilling and stressful; its actual impact on individuals depends on previous vulnerability as well as on active and dormant resources. Variations regarding cultural, socioeconomic or relational resources embedded in personal networks available to individuals are key indicators to explain the different patterns following which life trajectories are shaped over time and systemically associated with social vulnerability. This chapter shows that life trajectories have to be understood dynamically as being both a product and a determinant of social vulnerability.
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Scott, David B., and Franco S. Medioli. "Sea-Level Indicators: Biological in Depositional Sequences." In Encyclopedia of Earth Sciences Series. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-93806-6_273.
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Scott, David B., and Franco S. Medioli. "Sea-Level Indicators-Biological in Depositional Sequences." In Encyclopedia of Earth Sciences Series. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-48657-4_273-2.
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Healy, Terry R., Katherine Stone, Orville Magoon, et al. "Sea-Level Indicators—Biological in Depositional Sequences." In Encyclopedia of Coastal Science. Springer Netherlands, 2005. http://dx.doi.org/10.1007/1-4020-3880-1_273.
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Cutajar, Martina, and Sandro Lanfranco. "Spatial displacement of nearshore vegetation in response to artificial changes in coastal morphology." In Ninth International Symposium “Monitoring of Mediterranean Coastal Areas: Problems and Measurement Techniques”. Firenze University Press, 2022. http://dx.doi.org/10.36253/979-12-215-0030-1.59.
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This study characterizes the zonation of coastal vegetation in six coastal sites in Malta. The vegetation sequence on the coastal zone is predictable and displaces in response to changes in shoreline. The halophyte Limbarda crithmoides was used as an indicator species to ‘locate’ the position of the sequence. The vegetation surveys were used to construct a Gaussian distribution model for this species. Peak density and peak distance from the shore were positively correlated with exposure. The models were used to simulate the predicted shift of the vegetation in response to a modified shoreline
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Siegert, C., A. Y. Derevyagin, G. N. Shilova, W. D. Hermichen, and A. Hiller. "Paleoclimatic Indicators from Permafrost Sequences in the Eastern Taymyr Lowland." In Land-Ocean Systems in the Siberian Arctic. Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-60134-7_38.
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Sharma, Harshit, and Shri Kant. "Early Detection of Ransomware by Indicator Analysis and WinAPI Call Sequence Pattern." In Information and Communication Technology for Intelligent Systems. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-1747-7_20.
Full textConference papers on the topic "Sequence Indicators"
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Serge, Germanetti, and Erwan Guillanton. "An Alternative Approach for System Architecture Design." In Vertical Flight Society 70th Annual Forum & Technology Display. The Vertical Flight Society, 2014. http://dx.doi.org/10.4050/f-0070-2014-9649.
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In the frame of the avionics development, more and more risks have to be managed. The technology risk is the one which concerns most of the engineers. But industrial risk is perhaps more critical for a company. In the current context, the high level of integration to reduce weight and cost is the key factor that drives most of the Hardware developments. This paper addresses this problem, explains past experience, and provides rationale for evolution. The possibility to introduce a set of independent reusable sub-systems is proposed to ease incremental certification. The driven elements for selecting such a strategy are explained and will serve as Key Performance Indicators to manage system architecture choice, finalization of each independent reusable sub-systems perimeter and the sequence to implement them on the legacy and new helicopter fleet. Concrete applications are identified to deploy a scalable and configurable application of the modular and flexible architecture via a set of independent reusable sub-systems and Field Loadable Softwares. The EC175, developed according to this approach, is presented as an example. Finally, the topics to be discussed with the certification authorities are introduced.
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Anderko, Andrzej, and Patrick J. Shuler. "Modeling the Formation of Iron Sulfide Scales Using Thermodynamic Simulation Software." In CORROSION 1998. NACE International, 1998. https://doi.org/10.5006/c1998-98064.
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Abstract A program has been developed for generating stability diagrams that concisely represent the thermodynamic state of multicomponent, multiphase aqueous systems in wide ranges of temperature and component concentrations. The diagrams are based on a thermodynamic model that combines the Helgeson-Kirkham-Flowers equation of state for standard-state properties with a solutions nonideality model based on the activity coefficient expressions developed by Bromley and Pitzer. The diagrams offer a flexible choice of independent variables, which include component concentrations in addition to the potential and pH. The stability diagrams are used to predict the conditions that favor the formation of stable and metastable iron sulfide species, which are commonly deposited under oil field-related conditions. First, the diagrams have been applied to establish a sequence of transformations that iron sulfides undergo as they age. The predicted transformation sequences take into account environmental variables (e.g., hydrogen sulfide concentration, oxygen availability, etc.). The predictions are in agreement with experimental data on iron sulfide formation at the iron/solution interface and in bulk solution. The understanding of iron sulfide transformation sequences makes it possible to simulate experimental studies of H2S/CO2 corrosion in the presence or absence of oxygen. A comparison with laboratory corrosion rate data under gas pipeline conditions indicates that the magnitude of corrosion rates can be correlated with the predicted stability of metastable iron sulfide phases.
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Hansen, Douglas C., and Stephen C. Dexter. "A Novel Biopolymer and Its Application as an Anticorrosive for Stainless Steel Alloys in Seawater." In CORROSION 1993. NACE International, 1993. https://doi.org/10.5006/c1993-93491.
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Abstract The adhesive protein of the common blue mussel, Mytilus edulis(L) is a novel biopolymer in that it contains a catechol, L,3,4-dihydroxy-phenylalanine (L-Dopa) in its primary sequence. Adsorption of this protein onto S30403 stainless steel coupons imparts a significant resistance to corrosion when the test coupons are immersed in 3% NaCl and with an applied potential up to +350 mV (SCE). Comparison with other proteins and polymers such as serum albumin (BSA), a low molecular weight catechol (DHBA), and poly-L-lysine indicates that none are as effective as the mussel protein at inhibiting corrosion of the stainless steel alloy tested. This indicates that the adhesive protein may have an advantage over other organic polymers in use at the present time in corrosion control technology.
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Shi, Long-qing, Heng-qi Xin, Feng-jie Yang, Qiu Mei, and Shu-cai Li. "Feicheng coalfield sequence stratigraphy and correlation analysis of coal quality indicators." In 2010 2nd International Conference on Information Science and Engineering (ICISE). IEEE, 2010. http://dx.doi.org/10.1109/icise.2010.5688579.
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Mabrouk, Mai S., and Samir Y. Marzouk. "A chaotic study on pandemic and classical (H1N1) using EIIP sequence indicators." In 2nd International Conference on Computer Technology and Development (ICCTD 2010). IEEE, 2010. http://dx.doi.org/10.1109/icctd.2010.5645882.
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Sillen, Xavier, Jan Marivoet, Wim Cool, and Peter de Preter. "Testing Safety and Performance Indicators in an Assessment of the Long-Term Performance of the Geological Disposal of Spent Fuel in Boom Clay." In ASME 2003 9th International Conference on Radioactive Waste Management and Environmental Remediation. ASMEDC, 2003. http://dx.doi.org/10.1115/icem2003-4620.
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The classical numerical output, or indicator, from assessments of the long-term safety of geological disposal systems for high-level radioactive waste is the individual effective dose rate. This indicator is an estimate of the possible individual health detriment and it is commonly compared to regulatory limits for assessing the safety of other nuclear activities as well, such as medical and industrial activities. As a safety indicator, the individual dose rate provides an estimate of the overall safety of the disposal system. However, because of the time frames involved in safety assessments of geological disposal systems, the need arises of complementary safety indicators that could be less affected by uncertainties like those associated with future human behaviour or the effects of climate change on the biosphere and the aquifers. Such alternative safety indicators can be, for example, radionuclide concentrations in the groundwater or fluxes to the biosphere due to a repository. Safety indicators only tell how globally safe a disposal system is. For confidence building, performance indicators can be used in addition to tell how the system works. In particular, performance indicators such as fluxes, activities or activity concentrations of selected radionuclides can show how the different components of the system fulfil their safety functions and contribute to the overall safety. The SPIN project of the European Commission assessed the usefulness of seven safety indicators and fourteen performance indicators by testing them in four actual assessments of disposal systems in granite formations. In this paper, indicators calculated from an assessment of the disposal of spent fuel in the poorly indurated Boom Clay formation are presented. Conclusions from the SPIN project that hold for repositories in clays are highlighted, as well as results that illustrate differences between the granite and clay disposal options. Finally, various performance and safety indicators are combined into a logical sequence to comprehensively present, and explain, the results of a safety assessment.
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Long, Zi, Lianzhi Tan, Shengping Zhou, Chaoyang He, and Xin Liu. "Collecting Indicators of Compromise from Unstructured Text of Cybersecurity Articles using Neural-Based Sequence Labelling." In 2019 International Joint Conference on Neural Networks (IJCNN). IEEE, 2019. http://dx.doi.org/10.1109/ijcnn.2019.8852142.
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Arévalo, P., F. Schuberth, R. Aragall, et al. "Automated Pump Startup: A Collaborative Approach Towards Drilling Systems Automation." In IADC/SPE International Drilling Conference and Exhibition. SPE, 2024. http://dx.doi.org/10.2118/217746-ms.
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Abstract Automated rig pump startup sequences are a common component of rig control systems (RCS) where the operator programs a sequence to the controller for its execution. This sequence is entered manually and it does not change unless the operator modifies it. The current paper presents a new approach towards pumps management, where the startup sequence is updated automatically for every new startup event, considering the current state of the equipment and the formation downhole. A digital twin of the wellbore equipped with physics-based transient models calculates the hydraulic parameters to build the startup sequence for every pump startup event. The startup sequence is updated continuously and automatically while drilling using the current state of the formation and rig equipment as inputs. The sequence calculated by the digital twin in real-time is then transmitted to a hydraulics automation application to monitor the execution of the startup events. In addition, the hydraulics application can write the startup sequence to automated drilling control systems (ADCS) to execute the pump startup process using tailored sequences for every event. The transient hydraulic model that enables the estimation of a safe and optimum pump startup sequence has been integrated into digital twins used during pre-job planning as well as in real-time deployments. The model successfully updates the startup sequence in response to changes in pressure limitations at surface and downhole. In addition, the model responds to changes in the gel formation process to adjust the startup sequence accordingly. Furthermore, the digital twin calculates the hydraulic limits to consider for an effective monitoring, such as the flow rate, surface pressure, flow rate gradient and pressure gradient at surface. The calculated sequence and limits are transmitted to the hydraulics automation application, which monitors the execution of the startup sequence and calculates key performance indicators related to the process. This makes it possible to identify invisible lost time during startup operations. Furthermore, the startup sequence is exposed by the hydraulics automation application to ADCS to automate the execution of the startup and shutdown processes. A case study from the North Sea confirms the effectiveness of the approach and illustrates its benefits. It illustrates the collaboration between multiple advisors and a single ADCS, when all features are deployed simultaneously in real-time, and then executed automatically by the ADCS. Four different applications were deployed in connection to the ADCS, namely the pump management application, tripping advisor, rate of penetration (ROP) optimization and stringer drilling (SD) advisor. In contrast to mechanical automation practices, the proposed method automatically calculates a new sequence for the pumps for every new startup event, considering the pressure environment at surface and downhole. In addition, the sequence is transmitted to the ADCS for execution and real-time monitoring, closing the control loop to the equipment.
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Wang, Junzhe, and Evren M. Ozbayoglu. "Application of Recurrent Neural Network Long Short-Term Memory Model on Early Kick Detection." In ASME 2022 41st International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/omae2022-78739.
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Abstract Long-short term memory [1] (LSTM) is an artificial Recurrent Neural Network (RNN) architecture capable of performing deep learning tasks. With the special feedback feature, the LSTM network is suitable for processing a sequence of data and making a sequence of predictions. It has been successfully applied to many disciplines such as speech recognition, language translation, time series forecasting, and anomaly detection. In this paper, the RNN-LSTM network is applied to real-time drilling data to study the complex dependencies between multiple drilling parameters and common kick indicators. A well-trained model will use the concept of the sliding window to continuously predict the unforeseen value of sensitive kick indicators. With proper analysis, the predicted result is helpful to detect kicks ahead of time. This paper also proposed a general workflow to easily visualize the prediction results. Compared with other time series prediction methods, the LSTM network has the advantages of more accurate multi-step prediction, more physical, and more flexible. The proposed LSTM network uses accelerated GPU computing, the fast computational speed makes both online and offline learning possible. It is concluded that this approach is capable of accurately predicting kick indicators under certain circumstances. It may provide innovative guidance for the application of the LSTM network in early kick detection and future study.
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Chen, Qinglian, Bitao Yao, and Duc Truong Pham. "Sequence-Dependent Robotic Disassembly Line Balancing Problem Considering Disassembly Path." In ASME 2020 15th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/msec2020-8268.
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Abstract For the realization of environmental protection and resource conservation, remanufacturing is of great significance. Disassembly is a key step in remanufacturing, the disassembly line system is the main scenario for product disassembly, usually consisting of multiple workstations, and has prolific productivity. The application of the robots in the disassembly line will eliminate various problems caused by manual disassembly. Moreover, the disassembly line balancing problem (DLBP) is of great importance for environmental remanufacturing. In the past, disassembly work was usually done manually with high cost and relatively low efficiency. Therefore, more and more researches are focusing on the automatic DLBP due to its high efficiency. This research solves the sequence-dependent robotic disassembly line balancing problem (SDRDLBP) with multiple objectives. It considers the sequence-dependent time increments and requires the generated feasible disassembly sequence to be assigned to ordered disassembly workstations according to the specific robotic workstation assignment method. In robotic DLBP, due to the special characteristics of robotic disassembly, we need to consider the moving time of the robots’ disassembly path during the disassembly process. This is also the first time to consider sequence-dependent time increments while considering the disassembly path of the robots. Then with the help of crossover and mutation operators, multi-objective evolutionary algorithms (MOEAs) are proposed to solve SDRDLBP. Based on the gear pump model, the performance of the used algorithm under different cycle times is analyzed and compared with another two algorithms. The average values of the HV and IGD indicators have been calculated, respectively. The results show the NSGA-II algorithm presents outstanding performance among the three MOEAs, and hence demonstrate the superiority of the NSGA-II algorithm.
Reports on the topic "Sequence Indicators"
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Wang, Ying yuan, Zechang Chen, Luxin Zhang, et al. A systematic review and network meta-analysis: Role of SNPs in predicting breast carcinoma risk. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.2.0092.
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Review question / Objective: P: Breast cancer patient; I: Single nucleotide polymorphisms associated with breast cancer risk; C: Healthy person; O: By comparing the proportion of SNP mutations in the tumor group and the control group, the effect of BREAST cancer risk-related SNP was investigated; S: Case-control study. Condition being studied: Breast cancer (BC) is one of the most common cancers among women, and its morbidity and mortality have continued to increase worldwide in recent years, reflecting the strong invasiveness and metastasis characteristics of this cancer. BC is a complex disease that involves a sequence of genetic, epigenetic, and phenotypic changes. Polymorphisms of genes involved in multiple biological pathways have been identified as potential risks of BC. These genetic polymorphisms further lead to differences in disease susceptibility and severity among individuals. The development of accurate molecular diagnoses and biological indicators of prognosis are crucial for individualized and precise treatment of BC patients.
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Lippolis, Nicolas. Diagnostics for Industrialisation: Growth, Sectoral Selection, and Constraints on Firms. Digital Pathways at Oxford, 2022. http://dx.doi.org/10.35489/bsg-dp-wp_2022/03.
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This paper reviews methods that have been suggested by the development literature on diagnostics. We subdivide the variety of diagnostics into three types: revealing the most binding constraints to economy-wide growth; selecting sectors in which to diversify; and identifying sources of sectoral underperformance. Each diagnostic method is judged on whether it: provides a structured way of performing diagnostics; directs analysts towards the right questions; and is efficient in its use of data and resources. After reviewing a variety of methods, we argue that, with respect to growth diagnostics, the best approach is to combine Hausmann’s, Rodrik and Velasco’s Growth Diagnostics with more encompassing and forward-looking methods. In sectoral selection, Hausmann and Hidalgo’s 'Product Space' analysis can serve as an adequate base for choosing sectors in which to diversify, but this method must be tempered by a much more diverse set of indicators that matter for sectoral choice. Finally, diagnostics at the sectoral level can be performed through a sequence of methods: starting from easily collectable perceptions data and progressing to more data-heavy techniques, depending on the time and resources available.
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Burns, Malcom, and Gavin Nixon. Literature review on analytical methods for the detection of precision bred products. Food Standards Agency, 2023. http://dx.doi.org/10.46756/sci.fsa.ney927.
Full textAbstract:
The Genetic Technology (Precision Breeding) Act (England) aims to develop a science-based process for the regulation and authorisation of precision bred organisms (PBOs). PBOs are created by genetic technologies but exhibit changes which could have occurred through traditional processes. This current review, commissioned by the Food Standards Agency (FSA), aims to clarify existing terminologies, explore viable methods for the detection, identification, and quantification of products of precision breeding techniques, address and identify potential solutions to the analytical challenges presented, and provide recommendations for working towards an infrastructure to support detection of precision bred products in the future. The review includes a summary of the terminology in relation to analytical approaches for detection of precision bred products. A harmonised set of terminology contributes towards promoting further understanding of the common terms used in genome editing. A review of the current state of the art of potential methods for the detection, identification and quantification of precision bred products in the UK, has been provided. Parallels are drawn with the evolution of synergistic analytical approaches for the detection of Genetically Modified Organisms (GMOs), where molecular biology techniques are used to detect DNA sequence changes in an organism’s genome. The scope and limitations of targeted and untargeted methods are summarised. Current scientific opinion supports that modern molecular biology techniques (i.e., quantitative real-time Polymerase Chain Reaction (qPCR), digital PCR (dPCR) and Next Generation Sequencing (NGS)) have the technical capability to detect small alterations in an organism’s genome, given specific prerequisites of a priori information on the DNA sequence of interest and of the associated flanking regions. These techniques also provide the best infra-structure for developing potential approaches for detection of PBOs. Should sufficient information be known regarding a sequence alteration and confidence can be attributed to this being specific to a PBO line, then detection, identification and quantification can potentially be achieved. Genome editing and new mutagenesis techniques are umbrella terms, incorporating a plethora of approaches with diverse modes of action and resultant mutational changes. Generalisations regarding techniques and methods for detection for all PBO products are not appropriate, and each genome edited product may have to be assessed on a case-by-case basis. The application of modern molecular biology techniques, in isolation and by targeting just a single alteration, are unlikely to provide unequivocal evidence to the source of that variation, be that as a result of precision breeding or as a result of traditional processes. In specific instances, detection and identification may be technically possible, if enough additional information is available in order to prove that a DNA sequence or sequences are unique to a specific genome edited line (e.g., following certain types of Site-Directed Nucelase-3 (SDN-3) based approaches). The scope, gaps, and limitations associated with traceability of PBO products were examined, to identify current and future challenges. Alongside these, recommendations were made to provide the infrastructure for working towards a toolkit for the design, development and implementation of analytical methods for detection of PBO products. Recognition is given that fully effective methods for PBO detection have yet to be realised, so these recommendations have been made as a tool for progressing the current state-of-the-art for research into such methods. Recommendations for the following five main challenges were identified. Firstly, PBOs submitted for authorisation should be assessed on a case-by-case basis in terms of the extent, type and number of genetic changes, to make an informed decision on the likelihood of a molecular biology method being developed for unequivocal identification of that specific PBO. The second recommendation is that a specialist review be conducted, potentially informed by UK and EU governmental departments, to monitor those PBOs destined for the authorisation process, and actively assess the extent of the genetic variability and mutations, to make an informed decision on the type and complexity of detection methods that need to be developed. This could be further informed as part of the authorisation process and augmented via a publicly available register or database. Thirdly, further specialist research and development, allied with laboratory-based evidence, is required to evaluate the potential of using a weight of evidence approach for the design and development of detection methods for PBOs. This concept centres on using other indicators, aside from the single mutation of interest, to increase the likelihood of providing a unique signature or footprint. This includes consideration of the genetic background, flanking regions, off-target mutations, potential CRISPR/Cas activity, feasibility of heritable epigenetic and epitranscriptomic changes, as well as supplementary material from supplier, origin, pedigree and other documentation. Fourthly, additional work is recommended, evaluating the extent/type/nature of the genetic changes, and assessing the feasibility of applying threshold limits associated with these genetic changes to make any distinction on how they may have occurred. Such a probabilistic approach, supported with bioinformatics, to determine the likelihood of particular changes occurring through genome editing or traditional processes, could facilitate rapid classification and pragmatic labelling of products and organisms containing specific mutations more readily. Finally, several scientific publications on detection of genome edited products have been based on theoretical principles. It is recommended to further qualify these using evidenced based practical experimental work in the laboratory environment. Additional challenges and recommendations regarding the design, development and implementation of potential detection methods were also identified. Modern molecular biology-based techniques, inclusive of qPCR, dPCR, and NGS, in combination with appropriate bioinformatics pipelines, continue to offer the best analytical potential for developing methods for detecting PBOs. dPCR and NGS may offer the best technical potential, but qPCR remains the most practicable option as it is embedded in most analytical laboratories. Traditional screening approaches, similar to those for conventional transgenic GMOs, cannot easily be used for PBOs due to the deficit in common control elements incorporated into the host genome. However, some limited screening may be appropriate for PBOs as part of a triage system, should a priori information be known regarding the sequences of interest. The current deficit of suitable methods to detect and identify PBOs precludes accurate PBO quantification. Development of suitable reference materials to aid in the traceability of PBOs remains an issue, particularly for those PBOs which house on- and off-target mutations which can segregate. Off-target mutations may provide an additional tool to augment methods for detection, but unless these exhibit complete genetic linkage to the sequence of interest, these can also segregate out in resulting generations. Further research should be conducted regarding the likelihood of multiple mutations segregating out in a PBO, to help inform the development of appropriate PBO reference materials, as well as the potential of using off-target mutations as an additional tool for PBO traceability. Whilst recognising the technical challenges of developing and maintaining pan-genomic databases, this report recommends that the UK continues to consider development of such a resource, either as a UK centric version, or ideally through engagement in parallel EU and international activities to better achieve harmonisation and shared responsibilities. Such databases would be an invaluable resource in the design of reliable detection methods, as well as for confirming that a mutation is as a result of genome editing. PBOs and their products show great potential within the agri-food sector, necessitating a science-based analytical framework to support UK legislation, business and consumers. Differentiating between PBOs generated through genome editing compared to organisms which exhibit the same mutational change through traditional processes remains analytically challenging, but a broad set of diagnostic technologies (e.g., qPCR, NGS, dPCR) coupled with pan-genomic databases and bioinformatics approaches may help contribute to filling this analytical gap, and support the safety, transparency, proportionality, traceability and consumer confidence associated with the UK food chain.
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Wackett, Lawrence, Raphi Mandelbaum, and Michael Sadowsky. Bacterial Mineralization of Atrazine as a Model for Herbicide Biodegradation: Molecular and Applied Aspects. United States Department of Agriculture, 1999. http://dx.doi.org/10.32747/1999.7695835.bard.
Full textAbstract:
Atrazine is a broadly used herbicide in agriculture and it was used here as a model to study the biodegradation of herbicides. The bacterium Pseudomonas sp. ADP metabolizes atrazine to carbon dioxide and ammonia and chloride. The genes encoding atrazine catabolism to cyanuric acid were cloned and expressed in Escherichia coli. The genes were designated atzA, atzB and atzC. Each gene was sequenced. The enzyme activities were characterized. AtzA is atrazine chlorohydrolase which takes atrazine to hydroxyatrizine. AtzB is hydroxyatrazine N-ethylaminohydrolase which produces N-isopropylammelide and N-ethylamine. AtzC is N-isopropylammelide N-isopropylaminohydrolase which produces cyanuric acid and N-isopropylamine. Each product was isolated and characterized to confirm their identity by chromatography and mass spectrometry. Sequence analysis indicated that each of the hydrolytic enzymes AtzA, AtzB and AtzC share identity which the aminohydrolase protein superfamily. Atrazine chlorohydrolase was purified to homogeneity. It was shown to have a kcat of 11 s-1 and a KM of 150 uM. It was shown to require a metal ion, either Fe(II), Mn(II) or Co(II), for activity. The atzA, atzB and atzC genes were shown to reside on a broad-host range plasmid in Pseudomonas sp. ADP. Six other recently isolated atrazine-degrading bacteria obtained from Europe and the United States contained homologs to the atz genes identified in Pseudomonas sp. ADP. The identity of the sequences were very high, being greater than 98% in all pairwise comparisons. This indicates that many atrazine-degrading bacteria worldwide metabolize atrazine via a pathway that proceeds through hydroxyatrazine, a metabolite which is non-phytotoxic and non-toxic to mammals. Enzymes were immobilized and used for degradation of atrazine in aqueous phases. The in-depth understanding of the genomics and biochemistry of the atrazine mineralization pathway enabled us to study factors affecting the prevalence of atrazine degradation in various agricultural soils under conservative and new agricultural practices. Moreover, Pseudomonas sp. ADP and/or its enzymes were added to atrazine-contaminated soils, aquifers and industrial wastewater to increase the rate and extent of atrazine biodegradation above that of untreated environments. Our studies enhance the ability to control the fate of regularly introduced pesticides in agriculture, or to reduce the environmental impact of unintentional releases.
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Jordan, Ramon L., Abed Gera, Hei-Ti Hsu, Andre Franck, and Gad Loebenstein. Detection and Diagnosis of Virus Diseases of Pelargonium. United States Department of Agriculture, 1994. http://dx.doi.org/10.32747/1994.7568793.bard.
Full textAbstract:
Pelargonium (Geranium) is the number one pot plant in many areas of the United States and Europe. Israel and the U.S. send to Europe rooted cuttings, foundation stocks and finished plants to supply a certain share of the market. Geraniums are propagated mainly vegetatively from cuttings. Consequently, viral diseases have been and remain a major threat to the production and quality of the crop. Among the viruses isolated from naturally infected geraniums, 11 are not specific to Pelargonium and occur in other crops while 6 other viruses seem to be limited to geranium. However, several of these viruses are not sufficiently characterized to conclude that they are distinct agents and their nomenclature and taxonomy are confusing. The ability to separate, distinguish and detect the different viruses in geranium will overcome obstacles te developing effective detection and certification schemes. Our focus was to further characterize some of these viruses and develop better methods for their detection and control. These viruses include: isolates of pelargonium line pattern virus (PLPV), pelargonium ringspot virus (PelRSV), pelargonium flower break virus (PFBV), pelargonium leaf curl (PLCV), and tomato ringspot virus (TomRSV). Twelve hybridoma cell lines secreting monoclonal antibodies specific to a geranium isolate of TomRSV were produced. These antibodies are currently being characterized and will be tested for the ability to detect TomRSV in infected geraniums. The biological, biochemical and serological properties of four isometric viruses - PLPV, PelRSV, and PFBV (and a PelRSV-like isolate from Italy called GR57) isolated from geraniums exhibiting line and ring pattern or flower break symptoms - and an isolate ol elderbeny latent virus (ELV; which the literature indicates is the same as PelRSV) have been determined Cloned cDNA copies of the genomic RNAs of these viruses were sequenced and the sizes and locations of predicted viral proteins deduced. A portion of the putative replicase genes was also sequenced from cloned RT-PCR fragments. We have shown that, when compared to the published biochemical and serological properties, and sequences and genome organizations of other small isometric plant viruses, all of these viruses should each be considered new, distinct members of the Carmovirus group of the family Tombusviridae. Hybridization assays using recombinant DNA probes also demonstrated that PLPV, PelRSV, and ELV produce only one subgenomic RNA in infected plants. This unusual property of the gene expression of these three viruses suggests that they are unique among the Carmoviruses. The development of new technologies for the detection of these viruses in geranium was also demonstrated. Hybridization probes developed to PFBV (radioactively-labeled cRNA riboprobes) and to PLPV (non-radioactive digoxigenin-labeled cDNAs) were generally shown to be no more sensitive for the detection of virus in infected plants than the standard ELISA serology-based assays. However, a reverse transcriptase-polymerase chain reaction assay was shown to be over 1000 times more sensitive in detecting PFBV in leaf extracts of infected geranium than was ELISA. This research has lead to a better understanding of the identity of the viruses infecting pelargonium and to the development of new tools that can be used in an improved scheme of providing virus-indexed pelargonium plants. The sequence information, and the serological and cloned DNA probes generated from this work, will allow the application of these new tools for virus detection, which will be useful in domestic and international indexing programs which are essential for the production of virus-free germplasm both for domestic markets and the international exchange of plant material.
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Padget, C. D. W., D. R. M. Pattison, D. P. Moynihan, and O. Beyssac. Pyrite and pyrrhotite in a prograde metamorphic sequence, Hyland River region, SE Yukon: implications for orogenic gold. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/328987.
Full textAbstract:
The distribution of pyrite and pyrrhotite is documented within an andalusite-sillimanite type (high-temperature, low-pressure) metasedimentary succession exposed in the Hyland River region of southeastern Yukon, Canada. The following metamorphic zones are recognized: chlorite, biotite, cordierite/staurolite (porphyroblast-in), andalusite, sillimanite, and K-feldspar + sillimanite. Pyrite occurs in the chlorite zone through the biotite zone, while pyrrhotite occurs from the chlorite zone to K-feldspar + sillimanite zone. The pyrite-pyrrhotite transition, therefore, occupies an interval in the chlorite and lower biotite zones that is terminated upgrade by a pyrite-out isograd in the upper part of the biotite zone or lowest grade part of the cordierite/staurolite zone. Pressure and temperature conditions of the rocks were estimated from phase equilibrium modelling and from Raman spectroscopy of carbonaceous material (RSCM) thermometry. Modelling indicates pressures of 3.7-4.1 kbar with temperatures of ~425 °C at the biotite isograd, 560-570 °C for chlorite-out/porphyroblast-in, ~575 °C for andalusite-in, 575-600 °C for the sillimanite isograd, and 645-660 °C at the K-feldspar + sillimanite isograd. RSCM temperatures are greater than or equal to 420 °C in the Chl zone, 500 °C at the Bt isograd, 525-550 °C for porphyroblast-in isograd, ~550 °C at the And isograd, and 580 °C at the Sil isograd. These results suggest the pyrite-pyrrhotite transition occurs from less than or equal to 420°C to ~560 °C. Thermodynamic modelling shows 0.6 wt. % H2O is released during metamorphism over the ~140 °C interval of the pyrite-pyrrhotite transition. The gradual release of fluid in the biotite zone is interpreted to have broadened the pyrite-pyrrhotite transition compared to other studies that predict a small interval of vigorous fluid release associated with volumetric chlorite consumption. Samples from the pyrite-pyrrhotite transition zone contain lower whole rock and pyrite Au values than samples from unmetamorphosed/lower rocks, suggesting that Au was removed from the rock at conditions below the pyrite-pyrrhotite transition (&amp;lt;420 °C). The chlorite zone and higher-grade metamorphic rocks of the Hyland River area do not appear to be a plausible source region for orogenic gold.
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Yaron, Zvi, Abigail Elizur, Martin Schreibman, and Yonathan Zohar. Advancing Puberty in the Black Carp (Mylopharyngodon piceus) and the Striped Bass (Morone saxatilis). United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7695841.bard.
Full textAbstract:
Both the genes and cDNA sequences encoding the b-subunits of black carp LH and FSH were isolated, cloned and sequenced. Sequence analysis of the bcFSHb and LHb5'flanking regions revealed that the promoter region of both genes contains canonical TATA sequences, 30 bp and 17 bp upstream of the transcription start site of FSHb and LHb genes, respectively. In addition, they include several sequences of cis-acting motifs, required for inducible and tissue-specific transcriptional regulation: the gonadotropin-specific element (GSE), GnRH responsive element (GRE), half sites of estrogen and androgen response elements, cAMP response element, and AP1. Several methods have been employed by the Israeli team to purify the recombinant b subunits (EtOH precipitation, gel filtration and lentil lectin). While the final objective to produce pure recombinantGtH subunits has not yet been achieved, we have covered much ground towards this goal. The black carp ovary showed a gradual increase in both mass and oocyte diameter. First postvitellogenic oocytes were found in 5 yr old fish. At this age, the testes already contained spermatozoa. The circulating LH levels increased from 0.5 ng/ml in 4 yr old fish to >5ng/ml in 5 yr old fish. In vivo challenge experiments in black carp showed the initial LH response of the pituitary to GnRH in 4 yr old fish. The response was further augmented in 5 yr old fish. The increase in estradiol level in response to gonadotropic stimulation was first noted in 4 yr old fish but this response was much stronger in the following year. In vivo experiments on the FSHb and LHb mRNA levels in response to GnRH were carried out on common carp as a model for synchronom spawning cyprinids. These experiments showed the prevalence of FSHP in maturing fish while LHP mRNA was prevalent in mature fish, especially in females. The gonadal fat-pad was found to originate from the retroperitoneal mesoderm and not from the genital ridge, thus differing from that reported in certain amphibians This tissue possibly serves as the major source of sex steroids in the immature black carp. However, such a function is taken over by the developing gonads in 4 yr old fish. In the striped bass, we described the ontogeny of the neuro-endocrine parameters along the brain-pituitary-gonadal axis during the first four years of life, throughout gonadal development and the onset of puberty. We also described the responsiveness of the reproductive axis to long-term hormonal manipulations at various stages of gonadal development. Most males reached complete sexual maturity during the first year of life. Puberty was initiated during the third year of life in most females, but this first reproductive cycle did not lead to the acquisition of full sexual maturity. This finding indicates that more than one reproductive cycle may be required before adulthood is reached. Out of the three native GnRHs present in striped bass, only sbGnRH and cGnRH II increased concomitantly with the progress of gonadal development and the onset of puberty. This finding, together with data on GtH synthesis and release, suggests that while sbGnRH and cGnRH II may be involved in the regulation of puberty in striped bass, these neuropeptides are not limiting factors to the onset of puberty. Plasma LH levels remained low in all fish, suggesting that LH plays only a minor role in early gonadal development. This hypothesis was further supported by the finding that experimentally elevated plasma LH levels did not result in the induction of complete ovarian and testicular development. The acquisition of complete puberty in 4 yr old females was associated with a rise in the mRNA levels of all GtH subunit genes, including a 218-fold increase in the mRNA levels of bFSH. mRNA levels of the a and PLH subunits increased only 11- and 8-fold, respectively. Although data on plasma FSH levels are unavailable, the dramatic increase in bFSH mRNA suggests a pivotal role for this hormone in regulating the onset and completion of puberty in striped bass. The hormonal regulation of the onset of puberty and of GtH synthesis and release was studied by chronic administration of testosterone (T) and/or an analog of gonadotropin-releasing hormone (G). Sustained administration of T+G increased the mRNA levels of the PLH subunit to the values characteristic of sexually mature fish, and also increased the plasma levels of LH. However, these changes did not result in the acceleration of sexual maturation. The mRNA levels of the bFSH subunit were slightly stimulated, but remained about 1/10 of the values characteristic of sexually mature fish. It is concluded that the stimulation of FSH gene expression and release does not lead to the acceleration of sexual maturity, and that the failure to sufficiently stimulate the bFSH subunit gene expression may underlie the inability of the treatments to advance sexual maturity. Consequently, FSH is suggested to be the key hormone to the initiation and completion of puberty in striped bass. Future efforts to induce precocious puberty in striped bass should focus on understanding the regulation of FSH synthesis and release and on developing technologies to induce these processes. Definite formulation of hormonal manipulation to advance puberty in the striped bass and the black carp seems to be premature at this stage. However, the project has already yielded a great number of experimental tools of DNA technology, slow-release systems and endocrine information on the process of puberty. These systems and certain protocols have been already utilized successfully to advance maturation in other fish (e.g. grey mullet) and will form a base for further study on fish puberty.
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List, Markus, Quirin Manz, Judith Bernett, et al. D2.1 Whitepaper on the platform knowledge base and data standards for in silico drug repurposing. REPO4EU, 2024. https://doi.org/10.58647/repo4eu.202400d2.1.
Full textAbstract:
Computational drug repurposing integrates data from diverse sources, such as sequence databases, GWAS studies, or high-throughput screens. Depending on the original use case or field of research, they vary in availability, timeliness, and compatibility with other data sources. Further, numerous computational tools have been introduced designed to identify active disease modules, indications, or drug-target interactions that use different methods and strategies while not adhering to standard guidelines. Clearing and harmonising the resulting inconsistencies consume essential resources such that compiling a well-structured work plan is fundamental. This whitepaper demonstrates the results of a systematic review effort of about 400 publications and proposes valuable resources and specific strategies for the REPO4EU consortium. We present reviews, databases and computational methods by their applicability to work package-specific tasks and suggest using popular data standards such as FASTQ, SAM and VCF for sequencing data. In detail, we argue how NeDRexDB should serve as an instance of a knowledge base in this project, outline how to create a reproducible yet flexible pipeline for module discovery, and lay out the application of the BioPAX standard for disease module representation. Future challenges include establishing guidelines for computational drug repurposing, flexible and standardised workflows, and comprehensive in silico validation. We are confident that this work will provide a solid basis for tackling them.
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Andreeva, Anna-Maria, Annika von Berg, Bibi van Ginkel, et al. Assessing Gender Perspectives in Preventing and Countering Violent Extremism Practices. International Centre for Counter Terrorism, 2024. http://dx.doi.org/10.19165/2024.7214.
Full textAbstract:
Despite the fact that research indicates that it is important to integrate a gender based approach for effective risk assessment and implementation of counter-terrorism (CT) and preventing and countering violent extremism (P/CVE) practices, such as rehabilitation and reintegration, our assessment of academic and grey literature on gender perspectives in CT and P/CVE practices shows that most of these practices remain gender-blind and tend to reproduce gender norms and stereotypes, while ignoring the complexity of women’s and men’s involvement in extremism. In this report, the authors did a thorough literature review of academic and grey literature published between 2014 and 2024, and conducted ten interviews to reflect on gender perspectives in CT and P/CVE practices. After a reflection on persisting gender construction, biases, and other problematic perspectives, the report focuses on the gender perspectives in analytical frameworks and toolkits used, for instance, for risk assessments. Next, the report elaborates on the gender perspectives in the implementation of the intervention phases, namely from law enforcement interventions, to exit processes. In the general conclusion, the authors argue that gender constructs, roles, and norms, and the way these are taken into consideration in the various P/CVE interventions, heavily impact the effectiveness of these efforts. They also conclude that there is a potential of an aggravating sequence of gender (mis)conceptions, since the gender constructs used in the risk assessments inform following interventions, such as disengagement, deradicalisation, and rehabilitation processes. The report ends with a set of recommendations tailored to different target groups.
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Ohad, Itzhak, and Himadri Pakrasi. Role of Cytochrome B559 in Photoinhibition. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7613031.bard.
Full textAbstract:
The aim of this research project was to obtain information on the role of the cytochrome b559 in the function of Photosystem-II (PSII) with special emphasis on the light induced photo inactivation of PSII and turnover of the photochemical reaction center II protein subunit RCII-D1. The major goals of this project were: 1) Isolation and sequencing of the Chlamydomonas chloroplast psbE and psbF genes encoding the cytochrome b559 a and b subunits respectively; 2) Generation of site directed mutants and testing the effect of such mutation on the function of PSII under various light conditions; 3) To obtain further information on the mechanism of the light induced degradation and replacement of the PSII core proteins. This information shall serve as a basis for the understanding of the role of the cytochrome b559 in the process of photoinhibition and recovery of photosynthetic activity as well as during low light induced turnover of the D1 protein. Unlike in other organisms in which the psbE and psbF genes encoding the a and b subunits of cytochrome b559, are part of an operon which also includes the psbL and psbJ genes, in Chlamydomonas these genes are transcribed from different regions of the chloroplast chromosome. The charge distribution of the derived amino-acid sequences of psbE and psbF gene products differs from that of the corresponding genes in other organisms as far as the rule of "positive charge in" is concerned relative to the process of the polypeptide insertion in the thylakoid membrane. However, the sum of the charges of both subunits corresponds to the above rule possibly indicating co-insertion of both subunits in the process of cytochrome b559 assembly. A plasmid designed for the introduction of site-specific mutations into the psbF gene of C. reinhardtii. was constructed. The vector consists of a DNA fragment from the chromosome of C. reinhardtii which spans the region of the psbF gene, upstream of which the spectinomycin-resistance-conferring aadA cassette was inserted. This vector was successfully used to transform wild type C. reinhardtii cells. The spectinomycin resistant strain thus obtained can grow autotrophically and does not show significant changes as compared to the wild-type strain in PSII activity. The following mutations have been introduced in the psbF gene: H23M; H23Y; W19L and W19. The replacement of H23 involved in the heme binding to M and Y was meant to permit heme binding but eventually alter some or all of the electron transport properties of the mutated cytochrome. Tryptophane W19, a strictly conserved residue, is proximal to the heme and may interact with the tetrapyrole ring. Therefore its replacement may effect the heme properties. A change to tyrosine may have a lesser affect on the potential or electron transfer rate while a replacement of W19 by leucine is meant to introduce a more prominent disturbance in these parameters. Two of the mutants, FW19L and FH23M have segregated already and are homoplasmic. The rest are still grown under selection conditions until complete segregation will be obtained. All mutants contain assembled and functional PSII exhibiting an increased sensitivity of PSII to the light. Work is still in progress for the detailed characterization of the mutants PSII properties. A tobacco mutant, S6, obtained by Maliga and coworkers harboring the F26S mutation in the b subunit was made available to us and was characterized. Measurements of PSII charge separation and recombination, polypeptide content and electron flow indicates that this mutation indeed results in light sensitivity. Presently further work is in progress in the detailed characterization of the properties of all the above mutants. Information was obtained demonstrating that photoinactivation of PSII in vivo initiates a series of progressive changes in the properties of RCII which result in an irreversible modification of the RCII-D1 protein leading to its degradation and replacement. The cleavage process of the modified RCII-D1 protein is regulated by the occupancy of the QB site of RCII by plastoquinone. Newly synthesized D1 protein is not accumulated in a stable form unless integrated in reassembled RCII. Thus the degradation of the irreversibly modified RCII-D1 protein is essential for the recovery process. The light induced degradation of the RCII-D1 protein is rapid in mutants lacking the pD1 processing protease such as in the LF-1 mutant of the unicellular alga Scenedesmus obliquus. In this case the Mn binding site of PSII is abolished, the water oxidation process is inhibited and harmful cation radicals are formed following light induced electron flow in PSII. In such mutants photo-inactivation of PSII is rapid, it is not protected by ligands binding at the QB site and the degradation of the inactivated RCII-D1 occurs rapidly also in the dark. Furthermore the degraded D1 protein can be replaced in the dark in absence of light driven redox controlled reactions. The replacement of the RCII-D1 protein involves the de novo synthesis of the precursor protein, pD1, and its processing at the C-terminus end by an unknown processing protease. In the frame of this work, a gene previously isolated and sequenced by Dr. Pakrasi's group has been identified as encoding the RCII-pD1 C-terminus processing protease in the cyanobacterium Synechocystis sp. PCC 6803. The deduced sequence of the ctpA protein shows significant similarity to the bovine, human and insect interphotoreceptor retinoid-binding proteins. Results obtained using C. reinhardtii cells exposes to low light or series of single turnover light flashes have been also obtained indicating that the process of RCII-D1 protein turnover under non-photoinactivating conditions (low light) may be related to charge recombination in RCII due to back electron flow from the semiquinone QB- to the oxidised S2,3 states of the Mn cluster involved in the water oxidation process.