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Journal articles on the topic 'Sequential principal curve'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Laparra, Valero, Sandra Jiménez, Gustavo Camps-Valls, and Jesús Malo. "Nonlinearities and Adaptation of Color Vision from Sequential Principal Curves Analysis." Neural Computation 24, no. 10 (2012): 2751–88. http://dx.doi.org/10.1162/neco_a_00342.

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Mechanisms of human color vision are characterized by two phenomenological aspects: the system is nonlinear and adaptive to changing environments. Conventional attempts to derive these features from statistics use separate arguments for each aspect. The few statistical explanations that do consider both phenomena simultaneously follow parametric formulations based on empirical models. Therefore, it may be argued that the behavior does not come directly from the color statistics but from the convenient functional form adopted. In addition, many times the whole statistical analysis is based on s

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Tanmay Ghosh, Khan Alamgir, Yang Xingyao, Muhammad Fayaz,. "Computer-Aided Diagnostic System for Digital Mammography." INFORMATION TECHNOLOGY IN INDUSTRY 9, no. 2 (2021): 989–95. http://dx.doi.org/10.17762/itii.v9i2.443.

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In this work, Computer-Aided Detection (CADe) and Computer-Aided Diagnosis (CADx) systems are developed and tested using the public and freely available mammographic databases named MIAS and DDSM databases, respectively. CADe system is used to differentiate between normal and abnormal tissues, and it assists radiologists to avoid missing a breast abnormality. At the same time, CADx is developed to distinguish between normal, benign and malignant breast tissues, and it helps radiologists to decide whether a biopsy is needed when reading a diagnostic mammogram or not. Any CAD system is constitut

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Miller, B. B., and W. E. Turner. "Monoclonal antibodies evaluated for use in a screening assay for conjugates of human serum albumin and pyridoxal 5'-phosphate." Clinical Chemistry 35, no. 8 (1989): 1756–60. http://dx.doi.org/10.1093/clinchem/35.8.1756.

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Abstract This enzyme immunoassay (EIA) was developed to measure pyridoxal 5'-phosphate bound to albumin (PLP-HSA) in human serum. The monoclonal antibody titer was 1:2000 and a sequential saturation analysis curve, prepared with samples containing from 10 to 1000 nmol/L, showed a 50% inhibition of antibody at 50 nmol of the conjugate per liter. The lower limit of detection for PLP-HSA was 10 nmol/L, a sensitivity 1000-fold greater than that for any potential interferent. When serum samples gave negative results in the assay, we compared the antigenicity of the principal sites for PLP binding o

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Hu, Yang, Yilin Qiao, Jingchun Chu, Ling Yuan, and Lei Pan. "Joint Point-Interval Prediction and Optimization of Wind Power Considering the Sequential Uncertainties of Stepwise Procedure." Energies 12, no. 11 (2019): 2205. http://dx.doi.org/10.3390/en12112205.

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To support high-level wind energy utilization, wind power prediction has become a more and more attractive topic. To improve prediction accuracy and flexibility, joint point-interval prediction of wind power via a stepwise procedure is studied in this paper. Firstly, time-information-granularity (TIG) is defined for ultra-short-term wind speed prediction. Hidden features of wind speed in TIGs are extracted via principal component analysis (PCA) and classified via adaptive affinity propagation (ADAP) clustering. Then, Gaussian process regression (GPR) with joint point-interval estimation abilit

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Perrotta, Adamaria, and Georgios Bliatsios. "Why segmentation matters: a Machine Learning approach for predicting loan defaults in the Peer-to-Peer (P2P) Financial Ecosystem." Risk Management Magazine 16, no. 2 (2021): 35–49. http://dx.doi.org/10.47473/2020rmm0089.

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Peer-to-Peer (P2P) lending is an online lending process allowing individuals to obtain or concede loans without the interference of traditional financial intermediaries. It has grown quickly the last years, with some platforms reaching billions of dollars of loans in principal in a short amount of time. Since each loan is associated with the probability of loss due to a borrower's failure, this paper addresses the borrower's default prediction problem in the P2P financial ecosystem. The main assumption, which makes this study different from the available literature, is that borrowers sharing t

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Yang, Fang, Murat Hamit, Chuan B. Yan, et al. "Feature Extraction and Classification on Esophageal X-Ray Images of Xinjiang Kazak Nationality." Journal of Healthcare Engineering 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/4620732.

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Esophageal cancer is one of the fastest rising types of cancers in China. The Kazak nationality is the highest-risk group in Xinjiang. In this work, an effective computer-aided diagnostic system is developed to assist physicians in interpreting digital X-ray image features and improving the quality of diagnosis. The modules of the proposed system include image preprocessing, feature extraction, feature selection, image classification, and performance evaluation. 300 original esophageal X-ray images were resized to a region of interest and then enhanced by the median filter and histogram equali

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Gershon, Steve, and Henry Okonkwo. "Evaluating the sensitivity, specificity and clinical utility of algorithms of spatial variation in sub-epidermal moisture (SEM) for the diagnosis of deep and early-stage pressure-induced tissue damage." Journal of Wound Care 30, no. 1 (2021): 41–53. http://dx.doi.org/10.12968/jowc.2021.30.1.41.

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Background: Sub-epidermal moisture (SEM) is a measurable biomarker detecting early pressure damage in order to objectively support current ‘gold standard’ skin tissue assessments (STA) for the detection of deep and early-stage pressure-induced injuries or ulcers (PI/PUs). Objective: A multi-site, dual arm, cross sectional, retrospective study was conducted to evaluate the sensitivity, specificity and clinical utility of spatial variation in SEM readings between healthy and damaged skin tissue. Method: The study enrolled 175 subjects: 125 with confirmed PI/PUs or suspected deep tissue injury (s

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Li, Wei, та Betty S. Pace. "Gene Expression Profiles Involved in γ to β Globin Gene Switching during Erythroid Maturation." Blood 106, № 11 (2005): 820. http://dx.doi.org/10.1182/blood.v106.11.820.820.

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Abstract The design and evaluation of therapies for sickle cell disease (SCD) rely on our understanding of hemoglobin accumulation during erythropoiesis and sequential globin gene expression (ε → Gγ → Aγ → δ → β) during development. To gain insights into globin gene switching, we completed time course micorarray analyses of erythroid progenitors to identify trans-factors involved in γ gene activation. Studies were completed to map the pattern of γ and β globin gene expression in progenitors grown from normal peripheral blood mononuclear cells. We compared cells grown in a 2-phase (phase 1, d0-

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Harasti, Paul R., and Roland List. "Principal Component Analysis of Doppler Radar Data. Part I: Geometric Connections between Eigenvectors and the Core Region of Atmospheric Vortices." Journal of the Atmospheric Sciences 62, no. 11 (2005): 4027–42. http://dx.doi.org/10.1175/jas3613.1.

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Abstract This is the first in a three-part series of papers that present the first applications of principal component analysis (PCA) to Doppler radar data. Although this novel approach has potential applications to many types of atmospheric phenomena, the specific goal of this series is to describe and verify a methodology that establishes the position and radial extent of the core region of atmospheric vortices. The underlying assumption in the current application is that the streamlines of the nondivergent component of the horizontal wind are predominantly circular, which is a characteristi

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Hengeveld, Paul J., Geoffrey M. Matthews, Yiguo Hu, et al. "Systematic Evaluation of Preclinical Genetically Determined Vs. "Stochastic"/Transient Resistance to High-Dose Melphalan Treatment in Multiple Myeloma." Blood 126, no. 23 (2015): 2484. http://dx.doi.org/10.1182/blood.v126.23.2484.2484.

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Abstract Myeloablative high-dose melphalan (HDM) followed by autologous stem cell transplantation (ASCT) remains one of the cornerstones of multiple myeloma (MM) treatment. Conceptually, HDM is based on the notion that a single melphalan dose (typically 200 mg/m2) exceeding the myelotoxicity threshold is associated with a steep increase in the dose response curve and higher degree of MM cell killing compared to fractionated delivery (without the need for hematopoietic stem cell support) of the same cumulative dose. Despite its importance in the therapeutic management of MM, HDM-ASCT is not con

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Schuster, Michael W., Mikkael A. Sekeres, Erick Gamelin, et al. "Phase 1 Study of AMG 900, an Orally Administered Pan-Aurora Kinase Inhibitor, in Adult Patients (Pts) with Acute Myeloid Leukemia (AML)." Blood 126, no. 23 (2015): 4929. http://dx.doi.org/10.1182/blood.v126.23.4929.4929.

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Abstract Background: Aurora kinases form a family of highly conserved serine/threonine protein kinases that regulate key steps in mitosis. Aurora kinases A and B are amplified and/or overexpressed in many malignancies, including various types of leukemia, and are associated with high proliferation rates, poor prognosis, and therapeutic resistance. AMG 900 is an investigational, orally administered, highly potent, selective, small-molecule pan-aurora kinase inhibitor that has shown single-agent activity in heavily pretreated pts with chemotherapy-resistant/refractory solid tumors. This open-lab

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Berbegal, Carmen, Luigimaria Borruso, Mariagiovanna Fragasso, et al. "A Metagenomic-Based Approach for the Characterization of Bacterial Diversity Associated with Spontaneous Malolactic Fermentations in Wine." International Journal of Molecular Sciences 20, no. 16 (2019): 3980. http://dx.doi.org/10.3390/ijms20163980.

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This study reports the first application of a next generation sequencing (NGS) analysis. The analysis was designed to monitor the effect of the management of microbial resources associated with alcoholic fermentation on spontaneous malolactic consortium. Together with the analysis of 16S rRNA genes from the metagenome, we monitored the principal parameters linked to MLF (e.g., malic and lactic acid concentration, pH). We encompass seven dissimilar concrete practices to manage microorganisms associated with alcoholic fermentation: Un-inoculated must (UM), pied-de-cuve (PdC), Saccharomyces cerev

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Srinagesh, Hrishikesh, Umut Ozbek, Urvi Kapoor, et al. "The MAGIC Algorithm Probability (MAP): A Novel Laboratory Biomarker for the Response to Treatment of Acute Graft-Versus-Host Disease." Blood 134, Supplement_1 (2019): 367. http://dx.doi.org/10.1182/blood-2019-122011.

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Systemic glucocorticoids are the principal treatment for acute graft-versus-host disease (GVHD), which remains the major cause of non-relapse mortality (NRM) after allogeneic hematopoietic cell transplantation (HCT). However, there are no validated biomarkers that measure a patient's response to glucocorticoid therapy, and thus response is evaluated by the change in clinical symptom severity. A major weakness in the predictive power of clinical responses is that changes to all organs are weighted equally even though the major driver of NRM is irreversible damage to the crypts of the GI tract.

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Gil Paz, Iriana, Paz González Martínez, Ana López Acón, et al. "La humanización de la asistencia sanitaria y su comunicación a través de la responsabilidad social = The humanization of health care and its communication through social responsibility." REVISTA ESPAÑOLA DE COMUNICACIÓN EN SALUD 9, no. 1 (2018): 54. http://dx.doi.org/10.20318/recs.2018.4254.

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Resumen: Los hospitales siempre han tenido, per se, una función social de gran importancia puesto que su principal actividad se centra en curar y cuidar a los enfermos. Sin embargo, lograr que esa asistencia sanitaria sea más humana resulta de la mayor relevancia. La aplicación de los conceptos que sustentan las iniciativas de Responsabilidad Social podrían constituir una herramienta adecuada para el análisis y la deliberación con el objetivo de desarrollar un plan para la humanización de la asistencia sanitaria en colaboración con la Xerencia de Xestión Integrada de Santiago de Compostela, pa

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15

Tan, K. T., N. Watanabe, and Y. Iwahori. "Impact Damage Resistance, Response, and Mechanisms of Laminated Composites Reinforced by Through-Thickness Stitching." International Journal of Damage Mechanics 21, no. 1 (2011): 51–80. http://dx.doi.org/10.1177/1056789510397070.

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In this article, the study of impact damage of laminated composites reinforced by through-thickness stitching is investigated and presented in threefold. Specimens stitched with varying stitch density and stitch thread thickness are subjected to low-velocity impact via a drop-weight machine. Impact damage resistance is first studied by examining the extent of delamination area in damaged specimens using ultrasonic C-scan analysis. It is revealed that higher stitch density is more capable of impeding delamination growth by arresting cracks at closer interval and suppressing crack propagation. T

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Langer, C. J., J. C. Leighton, R. L. Comis, et al. "Paclitaxel and carboplatin in combination in the treatment of advanced non-small-cell lung cancer: a phase II toxicity, response, and survival analysis." Journal of Clinical Oncology 13, no. 8 (1995): 1860–70. http://dx.doi.org/10.1200/jco.1995.13.8.1860.

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PURPOSE To determine the activity and toxicity of combination paclitaxel (24 hours) and carboplatin in advanced non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS Eligibility required measurable disease (stage IV or stage IIIB with malignant pleural effusion), Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1, absolute neutrophil count > or = 2,000/microL, platelet count > or = 100,000/microL serum creatinine concentration < or = 1.5 mg/dL, and bilirubin level < or = 2 mg/dL. Paclitaxel was initially administered at a dose of 135 mg/m2/d, followed by carbopl

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17

Dridge, Elizabeth J., Carys A. Watts, Brian J. N. Jepson, et al. "Investigation of the redox centres of periplasmic selenate reductase from Thauera selenatis by EPR spectroscopy." Biochemical Journal 408, no. 1 (2007): 19–28. http://dx.doi.org/10.1042/bj20070669.

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Periplasmic SER (selenate reductase) from Thauera selenatis is classified as a member of the Tat (twin-arginine translocase)-translocated (Type II) molybdoenzymes and comprises three subunits each containing redox cofactors. Variable-temperature X-band EPR spectra of the purified SER complex showed features attributable to centres [3Fe–4S]1+, [4Fe–4S]1+, Mo(V) and haem-b. EPR-monitored redox-potentiometric titration of the SerABC complex (SerA–SerB–SerC, a hetero-trimetric complex of αβγ subunits) revealed that the [3Fe–4S] cluster (FS4, iron-sulfur cluster 4) titrated as n=1 Nernstian compone

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18

Barro, Robert J., and David B. Gordon. "A Positive Theory of Monetary Policy in a Natural Rate Model." Credit and Capital Markets – Kredit und Kapital: Volume 52, Issue 4 52, no. 4 (2019): 505–26. http://dx.doi.org/10.3790/ccm.52.4.505.

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Abstract A discretionary policymaker can create surprise inflation, which may reduce unemployment and raise government revenue. But when people understand the policymaker’s objectives, these surprises can- not occur systematically. In equilibrium people form expectations rationally and the policymaker optimizes in each period, subject to the way that people form expectations. Then, we find that (1) the rates of monetary growth and inflation are excessive; (2) these rates depend on the slope of the Phillips curve, the natural unemployment rate, and other variables that affect the benefits and c

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19

Barua, Souptik, Hesham Elhalawani, Stefania Volpe, et al. "Computed Tomography Radiomics Kinetics as Early Imaging Correlates of Osteoradionecrosis in Oropharyngeal Cancer Patients." Frontiers in Artificial Intelligence 4 (April 9, 2021). http://dx.doi.org/10.3389/frai.2021.618469.

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Osteoradionecrosis (ORN) is a major side-effect of radiation therapy in oropharyngeal cancer (OPC) patients. In this study, we demonstrate that early prediction of ORN is possible by analyzing the temporal evolution of mandibular subvolumes receiving radiation. For our analysis, we use computed tomography (CT) scans from 21 OPC patients treated with Intensity Modulated Radiation Therapy (IMRT) with subsequent radiographically-proven ≥ grade II ORN, at three different time points: pre-IMRT, 2-months, and 6-months post-IMRT. For each patient, radiomic features were extracted from a mandibular su

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Bolaños-Aguilar, Eduardo Daniel, Christian Huyghe, and Javier Francisco Enríquez-Quiroz. "Flowering Dynamics in Alfalfa (Medicago sativa L.) Based on Heat Units." Agro Productividad 13, no. 12 (2021). http://dx.doi.org/10.32854/agrop.v13i12.1895.

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Objective: To describe the sequential pattern of reproductive development of Medicago sativa L. (flowering dynamic) using the relation between principal floral stem nodes and accumulated growing degree day (GDD) in different environmental conditions, and to determine the use of this relationship as a predictor of the seed harvesting date. Design/Methodology/Approach: It was carried out in random blocks and factorial arrangement of 2?5, with two repetitions. Each repetition was made up of 30 plants. Results: The flowering dynamic followed the same pattern between varieties, with a linear relati

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Lu, Lin, Firas S. Ahmed, Oguz Akin, et al. "Uncontrolled Confounders May Lead to False or Overvalued Radiomics Signature: A Proof of Concept Using Survival Analysis in a Multicenter Cohort of Kidney Cancer." Frontiers in Oncology 11 (May 27, 2021). http://dx.doi.org/10.3389/fonc.2021.638185.

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PurposeWe aimed to explore potential confounders of prognostic radiomics signature predicting survival outcomes in clear cell renal cell carcinoma (ccRCC) patients and demonstrate how to control for them.Materials and MethodsPreoperative contrast enhanced abdominal CT scan of ccRCC patients along with pathological grade/stage, gene mutation status, and survival outcomes were retrieved from The Cancer Imaging Archive (TCIA)/The Cancer Genome Atlas—Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) database, a publicly available dataset. A semi-automatic segmentation method was applied to segment ccR

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