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Journal articles on the topic 'Serial BBC'

Author: Grafiati

Published: 24 April 2022

Last updated: 30 July 2025

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1

Deutsch, Stephen. "Sounding the BBC Classic Serial, 1975–95." New Soundtrack 1, no. 2 (2011): 133–45. http://dx.doi.org/10.3366/sound.2011.0015.

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Maully, Gevintha Karunia. "Representasi Tokoh Wanita pada Kisah Fiksi Kriminal: Serial Televisi Sherlock BBC (2010)." Paradigma, Jurnal Kajian Budaya 4, no. 2 (2016): 102. http://dx.doi.org/10.17510/paradigma.v4i2.45.

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<p>Sherlock BBC (2010) is one of the latest adaptations of Sherlock Holmes. By using the modern era as its sett ing, Sherlock off ers something different compared to previous Sherlock Holmes adaptations. This research focuses on the representation of female characters on Sherlock according to an issue that already chosen which is women and crime. The theories and concepts which are used on this research are gender construction in Victorian Era, the concept of femme-fatale and crime fi ction characteristics. I argue that there are some substantial diff erences of female characters’ repres

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Watts, Andrew. "Balzac on the BBC: Serial Breaks and Adaptive Returns inPère Goriot(1968)." Dix-Neuf 18, no. 2 (2014): 180–92. http://dx.doi.org/10.1179/1478731814z.00000000052.

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Ayustin, Evira, and Maylanny Christin. "ANALISIS WACANA KRITIS MODEL SARA MILLS PADA SERIAL PEAKY BLINDERS (ANALISIS GENDER PADA MEDIA AUDIO VISUAL)." Jurnal Darma Agung 30, no. 3 (2022): 1097. http://dx.doi.org/10.46930/ojsuda.v30i3.2388.

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Penelitian ini berusaha mengkaji isu gender berupa diskriminasi terhadap perempuan yang ditampilkan dalam serial Peaky Blinders yang berupa teks. Peaky Blinders adalah serial drama dari Inggris yang saat ini tamat hingga season 6 mengudara di BBC dan Netflix. Serial drama ini disutradarai oleh Otto Brust dengan pemeran utama Cillian Murphy. Peneliti melakukan penelitian dengan menggunakan pendekatan analisis wacana kritis model Sara Mills. Model analisis wacana Sara Mills sering dikenal sebagai stilistika feminis dalam kajian linguistik karena berfokus mengkaji wacana perempuan dari perspektif

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Greer, Chris, and Eugene McLaughlin. "The Celebrity Icon Mask: The Multi-Institutional Masking of Sir Jimmy Savile." Cultural Sociology 15, no. 3 (2021): 364–85. http://dx.doi.org/10.1177/1749975520985385.

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The aim of this article is to develop the concepts of masks and masking to interrogate the role of institutions in the co-production of ‘untouchable’ celebrity icon status. The empirical focus is the multi-institutional masking of Sir Jimmy Savile OBE KCSG. For decades, Savile was celebrated as one of the UK’s best-loved celebrity icons. One year after his death, he was exposed as a serial sexual predator. We argue that the largely compartmentalised official reports on Savile have presented a partial analysis. They have emphasised the importance of Savile’s celebrity status while taking it for

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Holmes, Su. "‘I'm certainly not one of these women's libbers’: Revisiting Gender inThe Family." Journal of British Cinema and Television 12, no. 3 (2015): 300–320. http://dx.doi.org/10.3366/jbctv.2015.0267.

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In 1974 the BBC screened the twelve-part documentary serial The Family. Yet despite the title of the programme, and its promise to open up the gendered terrain of the domestic sphere, The Family has largely been conceptualised with regard to discourses of class rather than gender. Given the famous slogan of second-wave feminism that the ‘personal is political’, The Family provides a fertile terrain upon which to consider how discourses relating to the women's movement at the time were negotiated within a particularly (tele)visible domestic sphere. It was often at the level of the micro-politic

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Barnett, Nick. "Cold War Nostalgia in The Game." Journal of British Cinema and Television 15, no. 3 (2018): 436–52. http://dx.doi.org/10.3366/jbctv.2018.0431.

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This article explores how nostalgia for both the Cold War and the 1970s in general became a key feature of the BBC drama The Game (2014). It argues that the serial situated the Cold War as a more stable era in international relations in which the enemy played by a specific set of rules, thus leading to a danger that was manageable and more predictable than the terror threat of the twenty-first century. Furthermore, the article argues that the serial presents the 1970s as a golden age which was defined by the continuity of consensus politics and communities of class and family. Finally, the art

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McNaughton, Douglas. "Cold War Spaces:Tinker Tailor Soldier Spyin Television and Cinema." Journal of British Cinema and Television 15, no. 3 (2018): 375–95. http://dx.doi.org/10.3366/jbctv.2018.0428.

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This article examines two adaptations of John le Carré’s 1974 novel Tinker, Tailor, Soldier, Spy: the 1979 BBC television serial and the 2011 cinema film, in order to investigate critical orthodoxies around the aesthetics of television and cinema. It examines the dialectical relationship between space and place, concluding that filming location acts as a ‘framing place’, shaping production practices and effecting a dialogic interchange between production space and narrative place. Drawing on original research interviews with production team members, it illuminates the process of production and

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Oldham, Joseph. "‘Disappointed romantics’: Troubled Heritage in the BBC's John le Carré Adaptations." Journal of British Cinema and Television 10, no. 4 (2013): 727–45. http://dx.doi.org/10.3366/jbctv.2013.0172.

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This article analyses three serialised adaptations of John le Carré novels produced by the BBC: Tinker Tailor Soldier Spy (1979), Smiley's People (1982) and A Perfect Spy (1987). It aims firstly to position them in the context of developments and trends during the period of the serials' production. It explores how, on the one hand, they were produced as variants on the classic serial model which aimed for a more contemporary focus and aesthetic in response to concurrent developments in British television drama, and on the other, how they have a complex and ambivalent relationship with the genr

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Kawai, Shoichiro. "New Interpretations and Adaptations of Shakespeare’s Plays in Japan from 2020 to 2023." Multicultural Shakespeare: Translation, Appropriation and Performance 30, no. 45 (2024): 21–35. https://doi.org/10.18778/2083-8530.30.02.

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This essay examines some notable Shakespearean productions and adaptations in Japan from 2020 to 2023. The main focus is on a Hamlet production by Mansai Nomura, a Kyogen performer, in March 2023; it was an amalgamation of the traditional Japanese theatres, such as Kyogen, Nô, Kabuki, and Bunraku. Mansai’s aspiration to produce Hamlet, utilizing all the elements of traditional Japanese art forms, began twenty years ago, when he played Hamlet in Jonathan Kent’s production in London and in Tokyo. He re-examined the text and offered a completely new interpretation of a scene, giving the play a fr

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McNaughton, Douglas. "Performance, place and screen." Critical Studies in Television: The International Journal of Television Studies 13, no. 3 (2018): 280–96. http://dx.doi.org/10.1177/1749602018780637.

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Screen performance is characterised by the interaction of performance, place and screen, but has suffered from critical neglect. Most accounts of this collaborative process focus on the performer in front of the camera rather than on the activities going on behind it. This article examines how performance is shaped within the BBC’s Outside Broadcast (OB) drama production paradigm of the 1970s and 1980s. The interactions of performers and camera operators combine to construct on-screen performance, since the generation of the screen frame necessarily ‘frames’ performance both literally and figu

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12

Steenberg, Lindsay. "The Fall and Television Noir." Television & New Media 18, no. 1 (2016): 58–75. http://dx.doi.org/10.1177/1527476416664185.

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This article analyzes the Belfast-set BBC series The Fall (2013–) as an illustrative example of television noir. It aims to use noir scholarship to investigate The Fall’s complex gender politics and genre position, and, more significantly, to use The Fall to illuminate the complex ways in which noir currently operates across Anglo-American television and culture. The Fall is self-conscious, if not self-reflexive, in its mobilization of noir to aspire to the cinematic. This article argues that the series, and others like it, use noir as a legitimation strategy, often to excuse prurient stories

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Barton, Ruth. "Trauma, Motive and the Post-Troubles Psychopath in The Fall." Television & New Media 22, no. 1 (2020): 32–46. http://dx.doi.org/10.1177/1527476420976118.

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This article discusses the depiction of the serial killer, Paul Spector, in the BBC/RTÉ television series The Fall (2013–2016). It complements existing scholarship on the series’ female detective by considering how Spector’s construction as a Gothic villain and victim of institutional abuse inflects The Fall’s positioning as a transnational genre production. It focuses on the use of Belfast as a setting, taking into account its historical positioning as a “Noir” city, and discusses the series’ spatial politics in the context of the city’s more recent history of sectarian divisions. It places t

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O'Brien, Sean. "The Law of Diminishing Returns:." Crossings: A Journal of English Studies 11 (March 1, 2020): 82–97. http://dx.doi.org/10.59817/cjes.v11i.437.

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The essay examines the representation of precarity in the BBC two series, The Fall (2013-), starring Gillian Anderson as detective superitendent Stella Gibson and Jamie Dornan as serial killer as Paul Spector. In the series, institutions of social reproduction are reaveled to be sclerotic, examplified not only in the austerity policies of fiscally insolvent national governments but also in the family and the couple, social forms integral to a system of crises management that depends upon feminized reproductive work. Here, precarity emerges as a double bind: a reproductive crisis that would see

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De Figueiredo, Camila Augusta Pires. "In the post-TV era: transmedia and fandom in Sherlock, by Moffat and Gatiss." Letras de Hoje 55, no. 1 (2020): 33789. http://dx.doi.org/10.15448/1984-7726.2020.1.33789.

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Serial narratives such as TV series have their own language, genres and narrative tools, according to their media specificities. It is observed that the television of today is going through a process of rapid cultural and technological transformations. Such advances have led to profound changes in the formats of the series, as well as in their modes of production and consumption. As for the production aspects, for example, we observe the creation of new narrative models in which the technological resources are shaped as extensions of the television product, creating a multiplatform or transmed

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Haggett, George K. "Philip Venables and Ted Huffman, Denis & Katya, London, Southbank Centre, Purcell Room, 13–14 March 2020." Tempo 74, no. 294 (2020): 85–86. http://dx.doi.org/10.1017/s0040298220000431.

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Oral history is experiencing something of a heyday in the public imagination. The past ten years have seen a proliferation of podcasts – Sarah Koenig's Serial, Brian Reed's S-Town, Jon Ronson's The Butterfly Effect – which revolve around the testimony of ordinary people. Many of their fictional counterparts, most overtly Archive 81, hinge around the very practice of documenting, archiving and interpreting oral histories. BBC radio's oral history The Century Speaks (1999) was broadcast to an audience of millions. In the same year, radio historian Susan Douglas presciently called for a return to

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Tincknell, Estella. "Dowagers, Debs, Nuns and Babies: The Politics of Nostalgia and the Older Woman in the British Sunday Night Television Serial." Journal of British Cinema and Television 10, no. 4 (2013): 769–84. http://dx.doi.org/10.3366/jbctv.2013.0174.

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The extensive commercial success of two well-made popular television drama serials screened in the UK at prime time on Sunday evenings during the winter of 2011–12, Downton Abbey (ITV, 2010–) and Call the Midwife (BBC, 2012–), has appeared to consolidate the recent resurgence of the period drama during the 1990s and 2000s, as well as reassembling something like a mass audience for woman-centred realist narratives at a time when the fracturing and disassembling of such audiences seemed axiomatic. While ostensibly different in content, style and focus, the two programmes share a number of distin

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Vij, Priya, and Kamlesh Kumar Yadav. "An Efficient Power Factor Maximization Model with Buk-Boost Converter in Power Systems." E3S Web of Conferences 540 (2024): 06007. http://dx.doi.org/10.1051/e3sconf/202454006007.

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The problem of power management in power systems has been well studied. There exist number of approaches towards power handling which consider input voltage, residual voltage in different capacitors and uses different converters to maximize the output voltage. However, the methods suffer to achieve higher performance in voltage stabilization in power systems. To handle this issue, an efficient buck boost converter based power factor maximization model (BBC-PFM) is presented in this paper. The model fabricated with k number of buck boost converter in serial. According to the design, the method

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19

Zimbroianu, Cristina. "The Reception of Olivia Manning’s The Great Fortune in Romania." Connections: A Journal of Language, Media and Culture 2, no. 1 (2021): 18–29. http://dx.doi.org/10.29173/connections34.

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Manning’s (1908-1980) novel The Great Fortune (1960) is the first Second World War novel of a six-part novel series titled Fortunes of War. Set in Bucharest, Romania, the novel portrays the historical events of the first year of the war (1939-1940) and how these affect Romanian society and the English community. The novel was well-received in England, and in 1987 was adapted to a television serial issued by BBC. In Romania, the response of the critics after the communist regime was rather harsh, accusing Manning of misinterpreting Romanian reality. Moreover, considering that Manning portrays n

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Chen, Jing, Likun Zhou, Zhuosong Yang, et al. "The Molecular and Function Characterization of Porcine MID2." Animals 13, no. 18 (2023): 2853. http://dx.doi.org/10.3390/ani13182853.

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Midline2 (MID2/TRIM1) is a member of the tripartite motif-containing (TRIM) family, which is involved in a wide range of cellular processes. However, fundamental studies on porcine MID2 (pMID2) are still lacking. In this study, we identified and characterized the full length MID2 gene of pig (Sus scrofa). The sequence alignment analysis results showed that pMID2 had an N-terminal RING zinc-finger domain, BBC domain, and C-terminal COS box, FN3 motif, and PRY-SPRY domain that were conserved and similar to those of other vertebrates. Furthermore, pMID2 had the highest expression levels in porcin

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Qi Loi, Janine En, Magdalene Li Ling Lee, Benjamin Boon Chuan Tan, and Brian See. "Time Course of Simulator Sickness in Asian Military Pilots." Aerospace Medicine and Human Performance 91, no. 11 (2020): 892–96. http://dx.doi.org/10.3357/amhp.5674.2020.

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INTRODUCTION: This study sought to determine the incidence, severity, and time-course of simulator sickness (SS) among Asian military pilots following flight simulator training.METHODS: A survey was conducted on Republic of Singapore Air Force pilots undergoing simulator training. Each subject completed a questionnaire immediately after (0H), and at the 3-h (3H) and 6-h (6H) marks. The questionnaire included the simulator sickness questionnaire (SSQ) and a subjective scale to rate their confidence to fly.RESULTS: In this study, 258 pilots with a median age of 31.50 yr (range, 2155 yr) and mean

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Tait, Frances. "Specialist Users of Serials – the BBC." Serials: The Journal for the Serials Community 5, no. 2 (1992): 53–57. http://dx.doi.org/10.1629/050253.

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Żur, Agnieszka. ""Studium w queerze" – queerowanie Sherlocka Holmesa." Annales Universitatis Paedagogicae Cracoviensis | Studia de Cultura 16, no. 4 (2024): 79–94. https://doi.org/10.24917/20837275.16.4.5.

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Celem artykułu jest przedstawienie i omówienie przypadków queerowania opowieści o Sherlocku Holmesie. Analiza zostaje przeprowadzona na przykładach: powieści gejowskiej The Sexual Adventures of Sherlock Holmes z 1971 r. i fanfiction na podstawie serialu Sherlock (2010–2017) produkcji BBC. Artykuł omawia różne strategie queerujące, odnosząc je do analizowanych przykładów. Porównane zostają również sposoby queerowania, którymi cechują się starsze dzieło i nowsze fanfiction.

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Parrish, Mark, Jay Unruh, and Robb Krumlauf. "BAC Modification through Serial or Simultaneous Use of CRE/Lox Technology." Journal of Biomedicine and Biotechnology 2011 (2011): 1–12. http://dx.doi.org/10.1155/2011/924068.

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Bacterial Artificial Chromosomes (BACs) are vital tools in mouse genomic analyses because of their ability to propagate large inserts. The size of these constructs, however, prevents the use of conventional molecular biology techniques for modification and manipulation. Techniques such as recombineering and Cre/Lox methodologies have thus become heavily relied upon for such purposes. In this work, we investigate the applicability of Lox variant sites for serial and/or simultaneous manipulations of BACs. We show that Lox spacer mutants are very specific, and inverted repeat variants reduce Lox

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Kempna-Pieniążek, Magdalena. "Inne światy? Krajobrazy i kosmobrazy w serialu Planety (2019)." Białostockie Studia Literaturoznawcze, no. 25 (2024): 95–113. https://doi.org/10.15290/bsl.2024.25.07.

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The author of the article looks at the particular relationship between terrestrial landscapes and spacescapes, understood as a kind of cultural landscape, in the BBC series The Planets (2019). The landscape strategies employed by the series’ creators are examined in the context of cinematic landscape theory and selected strands of astroculture studies. The author sees The Planets as an example of the effective use of terrestrial landscapes in the process of symbolic terraforming of selected Solar System objects. The main arguments in favour of this thesis are the three distinctive strategies p

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Schulz, Ellina, Almuth F. Kessler, Ellaine Salvador, et al. "EXTH-02. THE BLOOD BRAIN BARRIER (BBB) PERMEABILITY IS ALTERED BY TUMOR TREATING FIELDS (TTFIELDS) IN VIVO." Neuro-Oncology 21, Supplement_6 (2019): vi82. http://dx.doi.org/10.1093/neuonc/noz175.336.

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Abstract OBJECTIVE For glioblastoma patients Tumor Treating Fields (TTFields) have been established as adjuvant therapy. The blood brain barrier (BBB) tightly controls the influx of the majority of compounds from blood to brain. Therefore, the BBB may block delivery of drugs for treatment of brain tumors. Here, the influence of TTFields on BBB permeability was assessed in vivo. METHODS Rats were treated with 100 kHz TTFields for 72 h and thereupon i.v. injected with Evan’s Blue (EB) which directly binds to Albumin. To evaluate effects on BBB, EB was extracted after brain homogenization and qua

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Waubant, Emmanuelle. "Biomarkers Indicative of Blood-Brain Barrier Disruption in Multiple Sclerosis." Disease Markers 22, no. 4 (2006): 235–44. http://dx.doi.org/10.1155/2006/709869.

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Blood-brain barrier (BBB) disruption is one of the hallmarks of multiple sclerosis (MS). It is incompletely understood whether BBB disruption is the initial MS event leading to MS lesion formation or whether it is merely a consequence of cellular infiltration in the central nervous system (CNS). The presence of gadolinium enhancing (Gd+) lesions on serial brain MRI scans is frequently used to evaluate BBB disruption. The presence of Gd enhancement has therefore been used as a reference for most works evaluating promising biomarkers of BBB disruption that are reviewed here. These promising biom

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Urcuyo, Javier, Susan Christine Massey, Bianca-Maria Marin, Jann Sarkaria, and Kristin Swanson. "DRES-12. QUANTIFYING INDIVIDUALIZED ABT-414 SENSITIVITY AND BLOOD-BRAIN BARRIER PENETRANCE FROM SERIAL IMAGING OF PATIENT-DERIVED XENOGRAFTS MODELS OF GLIOBLASTOMA." Neuro-Oncology 21, Supplement_6 (2019): vi73—vi74. http://dx.doi.org/10.1093/neuonc/noz175.299.

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Abstract INTRODUCTION Glioblastoma (GBM) is an aggressive primary brain tumor, known for its poor prognosis. Due to its diffuse invasiveness into normal-appearing brain, localized treatments such as surgical resection and radiotherapy are typically supplemented with chemotherapy. However, to reach invading tumor cells, such antineoplastic drugs must cross the blood-brain barrier (BBB). That is, while angiogenesis induces BBB breakdown in dense tumor regions, the BBB remains rather intact for invading GBM cells. As a result, it is unclear whether BBB-impermeable drugs are delivered at a suffici

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Keßler, A. F., E. Salvador, D. Domröse, et al. "P11.28 Alteration of blood brain barrier (BBB) permeability by Tumor Treating Fields (TTFields) in vivo." Neuro-Oncology 21, Supplement_3 (2019): iii49. http://dx.doi.org/10.1093/neuonc/noz126.174.

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Abstract BACKGROUND Alternating electric fields with intermediate frequency (100 - 300 kHz) and low intensity (1 - 3 V/cm), known as Tumor Treating Fields (TTFields), have been established as a novel adjuvant therapy for glioblastoma (GBM) patients. The blood brain barrier (BBB) tightly controls the influx of the majority of compounds from blood to brain. Due to this regulation, the BBB may block delivery of drugs for treatment of brain tumors, in particular GBM. In this study, we investigated the influence of TTFields on BBB permeability in vivo. MATERIAL AND METHODS For determination of BBB

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Pillai, Deepu R., Michael S. Dittmar, Dobri Baldaranov, et al. "Cerebral Ischemia–Reperfusion Injury in Rats—A 3 T MRI Study on Biphasic Blood–Brain Barrier Opening and the Dynamics of Edema Formation." Journal of Cerebral Blood Flow & Metabolism 29, no. 11 (2009): 1846–55. http://dx.doi.org/10.1038/jcbfm.2009.106.

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Serial magnetic resonance imaging (MRI) was performed to investigate the temporal and spatial relationship between the biphasic nature of blood–brain barrier (BBB) opening and, in parallel, edema formation after ischemia–reperfusion (I/R) injury in rats. T2-weighted imaging combined with T2-relaxometry, mainly for edema assessment, was performed at 1 h after ischemia, after reperfusion, and at 4, 24 and 48 h after reperfusion. T1-weighted imaging was performed before and after gadolinium contrast at the last three time points to assess BBB integrity. The biphasic course of BBB opening with a s

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Sheybani, Natasha, Soumen Paul, Katelyenn McCauley, et al. "472 ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A502—A503. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0472.

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BackgroundThe natural disease course for glioblastoma (GB) entails invariably grim outcomes for patients. Phagocytic immunotherapies, such as CD47 blockade (e.g. mCD47), have recently demonstrated promise for GB therapy. However, their efficacy is challenged by presence of the blood brain and tumor barriers (BBB/BTB). Transient disruption of the BBB/BTB via focused ultrasound (FUS) and circulating microbubbles (MB) holds promise for improving therapeutic outcomes in the context of mCD47. However, critical questions regarding the optimal protocol for therapeutic antibody delivery with FUS remai

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Cui, Xiaohong, Stuart P. Adler, Andrew J. Davison, Larry Smith, EL-Sayed E. Habib, and Michael A. McVoy. "Bacterial Artificial Chromosome Clones of Viruses Comprising the Towne Cytomegalovirus Vaccine." Journal of Biomedicine and Biotechnology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/428498.

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Bacterial artificial chromosome (BAC) clones have proven invaluable for genetic manipulation of herpesvirus genomes. BAC cloning can also be useful for capturing representative genomes that comprise a viral stock or mixture. The Towne live attenuated cytomegalovirus vaccine was developed in the 1970s by serial passage in cultured fibroblasts. Although its safety, immunogenicity, and efficacy have been evaluated in nearly a thousand human subjects, the vaccine itself has been little studied. Instead, genetic composition and in vitro growth properties have been inferred from studies of laborator

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Ann Ellis, E., John R. Guy, Jeffrey R. Fitzsimmons, and Barbara L. Beck. "Antioxidant suppression of blood-brain barrier disruption and demyelination in experimental optic neuritis." Proceedings, annual meeting, Electron Microscopy Society of America 49 (August 1991): 112–13. http://dx.doi.org/10.1017/s0424820100084867.

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Hydrogen peroxide (H2O2) has been shown to play a major role in disruption of the blood-brain barrier (BBB) and demyelination in experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). Reactive oxygen species, H2O2 and superoxide, are discharged by inflammatory cells that infiltrate the central nervous system (CNS) in FAE. Hydrogen peroxide can be directly toxic or can be converted to hydroxyl radical and induce peroxidation of lipids such as myelin. Catalase and glutathione peroxidase are antioxidant enzymes which detoxify H2O2 to O2 and H2O.Strain-13 guine

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Park, T. S., Ernesto R. Gonzales, and Jeffrey M. Gidday. "Platelet-Activating Factor Mediates Ischemia-Induced Leukocyte-Endothelial Adherence in Newborn Pig Brain." Journal of Cerebral Blood Flow & Metabolism 19, no. 4 (1999): 417–24. http://dx.doi.org/10.1097/00004647-199904000-00007.

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The authors examined the involvement of platelet-activating factor (PAF) in mediating leukocyte adherence to brain postcapillary pial venules and altering blood-brain barrier (BBB) permeability during basal conditions and during reoxygenation after asphyxia in newborn piglets. Intravital epifluorescence videomicroscopy, closed cranial windows, and labeling of leukocytes with rhodamine 6G allowed us to obtain serial measurements of adherent leukocytes within postcapillary venules. Blood-brain barrier breakdown was determined by optical measures of cortical extravascular fluorescence intensity a

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Zhang, Yingqian, Feng Fan, Guojun Zeng, et al. "Temporal analysis of blood–brain barrier disruption and cerebrospinal fluid matrix metalloproteinases in rhesus monkeys subjected to transient ischemic stroke." Journal of Cerebral Blood Flow & Metabolism 37, no. 8 (2016): 2963–74. http://dx.doi.org/10.1177/0271678x16680221.

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Blood–brain barrier (BBB) disruption plays an important role in pathophysiological progress of ischemic stroke. However, our knowledge of the dynamic change of BBB permeability and its mechanism remains limited. In the current study, we used a non-human primate (NHP) MCAO model and a serial CSF sampling method that allowed us to determine the dynamic change of BBB permeability by calculating the CSF/serum albumin ratio (AR). We showed that AR increased rapidly and significantly after ischemia, and the fold increase of AR is highly correlated with the infarction size during the subacute phase.

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Jakiel, Rafał. "Wątki futurystyczne i cyberpunkowe w wybranych telewizyjnych produkcjach popkultury w kontekście retoryczno-językoznawczej analizy utworu audiowizualnego." Annales Universitatis Paedagogicae Cracoviensis | Studia de Cultura 9, no. 4 (2018): 104–15. http://dx.doi.org/10.24917/20837275.9.4.10.

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DOI 10.24917/20837275.9.4.10W artykule pokazano liczne możliwości podjęcia analizy językoznawczej filmów zawierających wątki futurystyczne i cyberpunkowe. Dokonany przeze mnie wybór materiału badawczego był nietypowy. Większość wybranych seriali telewizyjnych nie stanowi klasycznego przykładu analizowanej przeze mnie literatury i jej adaptacji. Próbowałem odnaleźć i opisać popkulturowe produkty tylko zainspirowane literaturą futurystyczną i cyberpunkową; takie, które nie muszą spełniać wszystkich warunków stawianych pracom tego nurtu, np. Westworld (HBO), Doctor Who (BBC) and Mr. Robot (USA Ne

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Karve, Aniruddha, Taukir Ahmed, Janki Desai, et al. "EXTH-99. SYSTEMIC AND BRAIN PHARMACOKINETICS OF A GABAA RECEPTOR AGONIST, AMLAL-101, AS AN INVESTIGATIONAL THERAPEUTIC FOR THE TREATMENT OF PRIMARY AND METASTATIC BRAIN CANCERS." Neuro-Oncology 24, Supplement_7 (2022): vii232—vii233. http://dx.doi.org/10.1093/neuonc/noac209.897.

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Abstract PURPOSE AMLAL-101 is a novel agent which preferentially targets α3, α5 subtypes of ɣ-amino butyric acid receptors and shows anti-tumor activity against disparate cancer types. AMLAL-101 is being advanced as an ‘add-on’ to potentiate treatment of primary and metastatic brain cancers. However, AMLAL-101 must penetrate the blood-brain barrier (BBB) and show sufficient brain retention. The primary purpose of this study was to determine the plasma pharmacokinetics (PK) and quantitative estimate of the BBB permeability of AMLAL-101. METHODS We performed intracranial microdialysis, employing

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Badger, Julie L., Carol A. Wass, Scott J. Weissman, and Kwang Sik Kim. "Application of Signature-Tagged Mutagenesis for Identification ofEscherichia coli K1 Genes That Contribute to Invasion of Human Brain Microvascular Endothelial Cells." Infection and Immunity 68, no. 9 (2000): 5056–61. http://dx.doi.org/10.1128/iai.68.9.5056-5061.2000.

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ABSTRACT Escherichia coli K1 is the leading cause of gram-negative bacterial meningitis in neonates. It is principally due to our limited understanding of the pathogenesis of this disease that the morbidity and mortality rates remain unacceptably high. To identify genes required for E. coli K1 penetration of the blood-brain barrier (BBB), we used the negative selection strategy of signature-tagged transposon mutagenesis (STM) to screen mutants for loss or decreased invasion of human brain microvascular endothelial cells (HBMEC) which comprise the BBB. A total of 3,360 insertion mutants of E. c

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Autry, Adam, Jeremy Gordon, Hsin-Yu Chen, et al. "CBMT-26. SERIAL CHARACTERIZATION OF HYPERPOLARIZED [1-13C]PYRUVATE METABOLISM IN PATIENTS WITH GLIOMA AND THE INFLUENCE OF BEVACIZUMAB." Neuro-Oncology 21, Supplement_6 (2019): vi38—vi39. http://dx.doi.org/10.1093/neuonc/noz175.148.

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Abstract Treatment-related changes often mimic or mask tumor on standard anatomic imaging, making it difficult to monitor disease recurrence. Hyperpolarized (HP) carbon-13 MR imaging allows for real-time non-invasive measurement of metabolism, which may improve patient surveillance. Here, we focused on characterizing serial HP scans in patients undergoing treatment compared to healthy controls. Serial dynamic HP C-13 MRI scans were performed on 5 patients with recurrent glioma (22 total) and 3 healthy controls (4 total) using an echo-planar imaging sequence (2.88-8cm3 spatial resolution, 3s te

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Smith, Marcus, Rosemary Dyson, Tudor Hale, Matthew Hamilton, John Kelly, and Peggy Wellington. "The Effects of Restricted Energy and Fluid Intake on Simulated Amateur Boxing Performance." International Journal of Sport Nutrition and Exercise Metabolism 11, no. 2 (2001): 238–47. http://dx.doi.org/10.1123/ijsnem.11.2.238.

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This study examined the effects of serial reductions in energy and fluid intake on two simulated boxing performances separated by 2 days recovery. Eight amateur boxers (age: 23.6 ± 3.2 years; height 175 ± 5 cm; body mass [BM] 73.3 ± 8.3 kg [Mean ± SD]) performed two simulated boxing bouts (BB) under normal (N-trial) and restricted (R-trial) diets in a counterbalanced design over 5 days. The trials were separated by a 9-day period of normal dietary behavior (X-trial). BM was recorded on days 1, 3, and 5 of each trial. Simulated bouts of three, 3-min rounds with 1-min recovery were completed on

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Phelan, Herb A., James H. Holmes, William L. Hickerson, et al. "52 Refinement of a Histologic Algorithm for Burn Depth Categorization Using 1142 Consecutive Burn Wound Biopsies." Journal of Burn Care & Research 43, Supplement_1 (2022): S35—S36. http://dx.doi.org/10.1093/jbcr/irac012.055.

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Abstract Introduction Our group previously reported a theoretical burn biopsy algorithm (BBA-V1) for the categorization of burn wound depth based on histologic analysis, and informed it with the largest series of burn wound biopsies in the literature. That iteration of the BBA resulted in clinical misclassification rates consistent with past literature. Since our last report of that process, we have refined the algorithm with new criteria and a larger repository of burn wound biopsies. Here, we sought to promulgate this newer, simpler version of the BBA (BBA-V2). Methods This was an IRB-approv

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McCarty, Joseph H. "MMP9 Clears the Way for Metastatic Cell Penetration Across the Blood–Brain Barrier." Cancer Research 83, no. 8 (2023): 1167–69. http://dx.doi.org/10.1158/0008-5472.can-23-0151.

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Abstract Although brain metastases are 10-fold more prevalent than primary brain cancers, relatively little is understood about the genes and pathways that promote metastatic cell entry, growth, and survival in the brain. Hence, determining how metastatic tumors colonize the brain and thrive within the neural microenvironment is a topic of both fundamental importance and direct clinical relevance. In this issue, a report by Karreman and colleagues explores pathways that are exploited by metastatic tumor cells to arrest in the circulation, cross the endothelial blood–brain barrier (BBB), and th

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Piazza, Martin, Jeeva Munasinghe, Roger Murayi, et al. "Simulating vasogenic brain edema using chronic VEGF infusion." Journal of Neurosurgery 127, no. 4 (2017): 905–16. http://dx.doi.org/10.3171/2016.9.jns1627.

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OBJECTIVETo study peritumoral brain edema (PTBE), it is necessary to create a model that accurately simulates vasogenic brain edema (VBE) without introducing a complicated tumor environment. PTBE associated with brain tumors is predominantly a result of vascular endothelial growth factor (VEGF) secreted by brain tumors, and VEGF infusion alone can lead to histological blood-brain barrier (BBB) breakdown in the absence of tumor. VBE is intimately linked to BBB breakdown. The authors sought to establish a model for VBE with chronic infusion of VEGF that can be validated by serial in-vivo MRI and

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Curran, Mary. "Serials Cataloging Cooperative Training Program (SCCTP) Train the Trainer Session, Vancouver, B.C., November 17-19, 1999." Serials Librarian 39, no. 2 (2000): 19–22. http://dx.doi.org/10.1300/j123v39n02_03.

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Bocan, Thomas M., Robert G. Stafford, Jennifer L. Brown, et al. "Characterization of Brain Inflammation, Apoptosis, Hypoxia, Blood-Brain Barrier Integrity and Metabolism in Venezuelan Equine Encephalitis Virus (VEEV TC-83) Exposed Mice by In Vivo Positron Emission Tomography Imaging." Viruses 11, no. 11 (2019): 1052. http://dx.doi.org/10.3390/v11111052.

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Traditional pathogenesis studies of alphaviruses involves monitoring survival, viremia, and pathogen dissemination via serial necropsies; however, molecular imaging shifts this paradigm and provides a dynamic assessment of pathogen infection. Positron emission tomography (PET) with PET tracers targeted to study neuroinflammation (N,N-diethyl-2-[4-phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide, [18F]DPA-714), apoptosis (caspase-3 substrate, [18F]CP-18), hypoxia (fluormisonidazole, [18F]FMISO), blood–brain barrier (BBB) integrity ([18F]albumin), and metabolism (fluorodeoxyglucose, [18

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Pijlman, Gorben P., Jessica E. van Schijndel, and Just M. Vlak. "Spontaneous excision of BAC vector sequences from bacmid-derived baculovirus expression vectors upon passage in insect cells." Journal of General Virology 84, no. 10 (2003): 2669–78. http://dx.doi.org/10.1099/vir.0.19438-0.

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Repeated baculovirus infections in cultured insect cells lead to the generation of defective interfering viruses (DIs), which accumulate at the expense of the intact helper virus and compromise heterologous protein expression. In particular, Autographa californica multicapsid nucleopolyhedovirus (AcMNPV) DIs are enriched in an origin of viral DNA replication (ori) not associated with the homologous regions (hrs). This non-hr ori is located within the coding sequence of the non-essential p94 gene. We investigated the effect of a deletion of the AcMNPV non-hr ori on the heterologous protein expr

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Sheybani, Natasha Diba, Alexandra R. Witter, Timothy N. Bullock, and Richard J. Price. "MR image-guided focused ultrasound immune modulation for glioma therapy." Journal of Immunology 200, no. 1_Supplement (2018): 178.26. http://dx.doi.org/10.4049/jimmunol.200.supp.178.26.

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Abstract Glioblastoma (GB) is the most common and malignant brain tumor. Despite standard treatment with surgery, radiation and chemotherapy, its diffuse nature and proclivity for recurrence renders it largely intractable. Immunotherapy (ITx) approaches (e.g. anti-PD1) may hold promise for treating GB; however, the blood-brain (BBB) and blood-tumor (BTB) barriers hinder delivery of systemically administered ITx drugs. A potential approach to enhancing ITx delivery is MRI-guided focused ultrasound (FUS), a non-invasive technique that, when combined with concomitant systemic injection of microbu

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Shan, Ying, Yajie Liu, Ziqi Liu, et al. "Development and application of an indirect enzyme-linked immunosorbent assay using recombinant S1 for serological testing of porcine epidemic diarrhea virus." Canadian Journal of Microbiology 65, no. 5 (2019): 343–52. http://dx.doi.org/10.1139/cjm-2018-0240.

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Porcine epidemic diarrhea virus (PEDV) causes severe infectious diseases in all ages of swine and leads to serious economic losses. Serologic tests are widely accepted and used to detect anti-PEDV antibodies that could indicate PEDV infection or vaccination. In this study, PEDV recombinant S1 protein (rS1) was expressed with the Bac-to-Bac system and purified by nickel-affinity chromatography. An indirect enzyme-linked immunosorbent assay based on rS1 (rS1-ELISA) was then developed and optimized by checkerboard assays with serial dilutions of antigen and serum. Serum samples from 453 domestic

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Salvador, Ellaine, Almuth Kessler, Julia Hoermann, et al. "Tumor treating fields effects on the blood-brain barrier in vitro and in vivo." Journal of Clinical Oncology 38, no. 15_suppl (2020): 2551. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.2551.

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2551 Background: The greatest hurdle, which even potent and effective drugs targeting central nervous system (CNS) tumors and other disorders face, is the blood brain barrier (BBB). The inability to cross the tight regulatory mechanism renders these drugs futile. Of late, administration of tumor treating fields (TTFields) as part of a combined treatment modality for glioblastoma demonstrated increased overall patient survival. Still, the effects of TTFields on the BBB have not yet been investigated. Here, we report the potential of TTFields application to open up the BBB. Methods: Murine brain

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Michenfelder, John D., and James H. Milde. "Nimodipine Does Not Affect Cerebral Lactate Levels following Complete Ischemia in Dogs." Journal of Cerebral Blood Flow & Metabolism 7, no. 5 (1987): 619–24. http://dx.doi.org/10.1038/jcbfm.1987.114.

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Nimodipine is known to improve postischemic cerebral blood flow (CBF) and neurologic outcome in experimental animals. Whether or not the two observations are related is unknown. This study searched for a possible improved rate of brain metabolic recovery in animals treated with nimodipine postischemia. Complete cerebral ischemia was produced for 11 min in 16 dogs, followed by reperfusion for 70 min. Prior to ischemia, glucose was administered (0.75 g · kg−1) in 12 dogs. Half of the glucose-treated dogs were given i.v. nimodipine, beginning 5 min postischemia (10 μg · kg−1 bolus followed by 1 μ

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