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Dissertations / Theses on the topic 'Serine hydrolases'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Fransson, Linda. "Enzyme substrate solvent interactions : a case study on serine hydrolases." Doctoral thesis, KTH, Biokemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4867.

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Reaction rates and selectivities were measured for transacylation of fatty acid esters in solvents catalysed by Candida antarctica lipase B and by cutinase from Humicola insolens. With these enzymes classical water-based enzymology can be expanded to many different solvents allowing large variations in interaction energies between the enzymes, the substrates and the surrounding. Further ,hydrolysis reactions catalysed by Bacillus subtilis esterase 2 were investigated. Thermodynamics analyses revealed that the enzyme contribution to reaction rate acceleration compared to acid catalysis was pure

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2

Elahi, AEM Rubayet. "Proteome-wide Functional Profiling of Serine Hydrolases in the Human Malaria Parasite." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/90181.

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The serine hydrolase (SH) enzyme superfamily is one of the largest and most diverse enzyme classes in eukaryotes and prokaryotes. The most virulent human malaria parasite Plasmodium falciparum has over 40 predicted serine hydrolases (SH). Prior investigation on a few of these have suggested their critical role in parasite biology. The majority of the SHs in P. falciparum have not been functionally characterized. Investigation of these uncharacterized SHs will provide new insights into essential features of parasite metabolism and possibly lead to new antimalarial targets. In this study, we hav

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3

Galmés, Ordinas Miquel Àngel. "Molecular insights into the promiscuity of serine hydrolases. Towards a computationally guided protocol for the redesign of enzymes." Doctoral thesis, Universitat Jaume I, 2022. http://dx.doi.org/10.6035/14122.2022.725777.

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Two serine hydrolases, Candida antarctica Lipase B (CALB) and para-nitrobenzyl (Bs2) esterase from Bacillus subtilis, were used as a model to study enzyme promiscuity through QM/MM methods and experimental enzymes kinetics. Both, the catalytic and the substrate promiscuity were studied. The hydrolysis of amides and the epoxidation of alkenes catalyzed by CALB were explored. Moreover, a computational scheme for the redesign of the Bs2 was also proposed. The electrostatic environment around the active site was analyzed and a map of structural determinants in the vicinity of the active site pocke

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4

Kreuzer, Johannes Verfasser], Stephan A. [Akademischer Betreuer] Sieber, and Aymelt [Akademischer Betreuer] [Itzen. "The Natural Product Acivicin as a Tool for ABPP and the Activity of Serine Hydrolases in Uterine Fibroids / Johannes Kreuzer. Gutachter: Aymelt Itzen ; Stephan A. Sieber. Betreuer: Stephan A. Sieber." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1071651544/34.

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5

Yedji, Rodrigue. "Perturbateurs endocriniens de type phtalate et poisson zèbre Danio rerio : approche chémoprotéomique pour l'identification des cibles et recherche de signatures d'exposition." Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0106.

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Les esters de phtalate constituent une famille de composés synthétiques très répandue du fait de leurs usages comme plastifiants. Ils entrent dans la composition de plusieurs produits plastiques tels que les emballages, les jouets, les produits cosmétiques, certains systèmes de toiture en plastique, ainsi que les matériaux de décoration de meubles. Les phtalates ne sont pas liés de manière covalente à la matrice des polymères et sont donc facilement rejetés dans l'environnement, entraînant par conséquent une exposition animale et humaine. En absence de produits de substitutions non-toxiques, l

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6

Hamberg, Anders. "Serine Hydrolase Selectivity : Kinetics and applications in organic and analytical chemistry." Doctoral thesis, KTH, Biokemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-12831.

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The substrate selectivities for different serine hydrolases were utilized in various applications, presented in papers I-VI. The articles are discussed in the thesis in view of the kinetics of the enzyme catalysis involved. In paper I the enantioselectivities towards a range of secondary alcohols were reversed for Candida antarctica lipase B by site directed mutagenesis. The thermodynamic components of the enantioselectivity were determined for the mutated variant of the lipase. In papers II-III Candida antarctica lipase B was engineered for selective monoacylation using two different approach

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7

Hamon, Nadège. "Synthese de nucleosides en serie carbocyclique à visée antivirale." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20087/document.

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Les analogues nucléosidiques constituent une famille importante d'agents thérapeutiques dans le traitement de maladies d'origine virale. Parmi ces composés, les nucléosides carbocycliques possèdent des propriétés biologiques intéressantes. Le premier chapitre de cette thèse est consacrée à la famille des neplanocines qui sont des carbonucleosides naturels. Nous avons détaillé l'interaction de ces composés avec leur principale cible, la S-adénosylhomocystéine hydrolase, ainsi que les différentes approches de synthèses de ces carbonucléosides et de leurs énantioméres avant de passer en revue leu

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8

Ambrose, Timothy James William. "Serine hydrolase activity and roles for monoacylglycerol lipase in innate immunity and intestinal inflammation." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:f7a12796-ae8f-4121-ab1a-26778261ac78.

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Detection of evolutionarily conserved pathogen motifs by pattern recognition receptors (PRRs), particularly on dendritic cells (DCs), is crucial for adequate immune responses. Defects in DC function are known to be associated with inflammatory bowel disease (IBD). The endocannabinoid system (ECS) is the system through which exocannabinoids such as Δ<sup>9</sup>-tetrahydrocannabinol and cannabidiol signal. Regarding inflammation, cannabinoids generally exert anti-inflammatory effects, including on experimental colitis. However, most work has been performed in animal models and less is known abo

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9

Ho, Cherry Pei-Yee. "Evaluation of a Serine Hydrolase Inhibitor JZL184 as an Immunomodulator against Avian Pathogenic Escherichia Coli O78 in Chickens." Thesis, Mississippi State University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10788360.

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<p> Studies with the serine hydrolase inhibitor JZL184 have suggested that enhanced 2-arachidonoylglycerol signaling could be strategized to stimulate innate immune cells to combat invading pathogens and improve host defense by prompting the systemic release of proinflammatory cytokines. Although the neurochemical effects of JZL184 were found to cultivate within 30 min in mice, its immune-regulating effects have been studied much later and its effects on chickens have not been clear. To explore the modulations in the chickens’ immune responses, we studied the effects of intraperitoneal i

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10

Kornahrens, Anne. "Methodology development and synthesis of a biologically relevant natural product and targeted scaffold discovery for serine hydrolase inhibition." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:4cf5026f-e421-4b0b-9f62-707622f780b7.

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The phenomenal potential of synthetic chemistry to influence small molecule therapeutic development represents my overarching theme. The goal of designing or discovering a novel clinical candidate or biological target can be achieved through a variety of avenues available to synthetic organic chemists. The potential of natural product total synthesis and inhibitor development as impactful projects were pursued with the use and development of methodology. The natural product streptonigrin, a potent antitumor antibiotic, showed promise in clinical trials ultimately terminated in the 1970s. The u

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11

Fransson, Linda. "Molecular modelling - understanding and prediction of enzyme selectivity." Licentiate thesis, KTH, School of Biotechnology (BIO), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-10532.

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<p>Molecular modelling strategies for evaluation of enzyme selectivity wereinvestigated with a focus on principles of how molecular interactionscould be evaluated to provide information about selectivity. Althoughmolecular modelling provides tools for evaluation of geometrical andenergy features of molecular systems, no general strategies for evaluationof enzyme selectivity exist. Geometrical analyses can be based uponinspection and reasoning about molecular interactions, which provide aneasily accessible way to gain information, but suffer from the risk of biasput in by the modeller. They can

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12

Veronique, Jacqueline. "Enzymes de la voie de l'acide shikimique chez les vegetaux : mecanismes mis en jeu par les hydrolases et synthese de substrats en serie quinique." Toulouse 3, 1988. http://www.theses.fr/1988TOU30100.

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13

Daâloul, Nabil. "Einsatz von Hydrolasen und Oxidoreduktasen zur Entfernung der vegetabilen Bestandteile aus der Wolle /." Aachen : Mainz, 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=013110447&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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14

Benard, Stefan. "Chemisches Signal und biologische Antwort : Modulation der Generierung reaktiver Sauerstoffverbindungen aus neutrophilen Granulozyten /." Leipzig : AVA, Akademische Verlagsanstalt, 2000. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009101788&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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15

Leppchen, Kathrin. "Anwendung von Saccharomyces cerevisiae in der Biotechnologie und Oberflächenchemie /." München : Verl. Dr. Hut, 2009. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=017317794&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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16

Hsieh, Yu, and 謝瑀. "Developing chemical probe for activity profile of serine hydrolases." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/28946423398059175235.

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碩士<br>國立陽明大學<br>生命科學暨基因體科學研究所<br>97<br>Serine hydrolases represent one of the largest and diverse families of enzymes comprising numerous proteases, lipases, esterases, and amidases. Serine hydrolases play important roles and also regulate numerous important functions in many organisms. Disorder of such serine hydrolases may cause different kinds of human diseases. To understand the functions of diverse serine hydrolases, it is necessary to develop a method to systematically detect or enrich serine hydrolases and thus the following studies of their biological significances. Fluorophosphonate/f

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17

Huang, Yi-Long, and 黃義龍. "Qualitative analysis of fluorophosphonate-based probes targeting serine hydrolases." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/13313719297128260180.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>98<br>Serine hydrolase family consists of more than 200 members and is one of the largest enzyme families in human genome. However, up to 50% of these enzymes remain unannotated and their substrates are still unknown. In addition, activities of increasing serine hydrolases were shown associated with diseases like cancer neoplasia and invasiveness etc. Therefore, the systematic identification of serine hydrolases which are associated with diseases is of great importance. In this study, two novel hydrophilic fluorophosphonate (FP)-based chemical probes, including FP-ed

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18

Harrison, Jenica Ledah. "The role of acanthamoeba culbertsoni serine proteases in abating microglial-like cell cytokines and chemokines /." 2009. http://hdl.handle.net/10156/2457.

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19

Hu, Rong-Chi, and 胡容綺. "Identification and Characterization of Serine Hydrolases in Senescence Using Chemical-based Proteomic Approach." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/77946475578088969137.

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碩士<br>國立臺灣大學<br>生物化學暨分子生物學研究所<br>104<br>Most of normal human somatic cells cannot divide indefinitely and eventually enter a state of irreversible proliferative arrest termed replicative senescence. Although previous researches have shown that telomere shortening is the major reason for inducing senescence in human somatic cells, factors that mediate and maintain senescence are largely unknown. Serine hydrolases is a large enzyme family which constitutes about 1% of the human proteome and many of them are involved in important physiological processes. In addition, many serine hydrolases have b

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20

Carvalho, Luís Miguel Afonso Ramos de. "3-Oxo-β-Sultams and 4-Oxo-β-Lactams as chemical tools for activity-based protein profiling of serine hydrolases". Doctoral thesis, 2019. http://hdl.handle.net/10451/42844.

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Activity-based protein profiling (ABPP) is a technique that analyzes the dynamics in enzymatic activity in complex proteomes by using small molecular probes, deemed activity-based probes (ABPs), containing a reactive group to covalently bind enzyme catalytic residues, a tag for detection of labeled targets and a linker as a spacer and also specificity-enhancing. Different reactive groups have been developed to engage a wide range of enzymatic families but there is a constant need to create new chemical tools to expand the pool of engageable targets. In this work we evaluated two 4-membered rin

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21

Guo, Jian-Liang, and 郭建良. "Conformational Analysis and QSAR for Serine Hydrolases Esterase of the Carbamyl C-N Bond of o,m,p-Di-N-Substituted Carbamyloxy Benzenes." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/68656801786077458974.

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22

Perez, Dianne Marie. "Structure-Function Studies of Serine Hydrolases: Synthesis of a Gene for α-Lytic Protease and the Purification and Characterization of a Mutant β-Lactamase". Thesis, 1988. https://thesis.library.caltech.edu/7523/5/Perez-dm-1988.pdf.

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<p>The author has constructed a synthetic gene for α-lytic protease. Since the DNA sequence of the protein is not known, the gene was designed by using the reverse translation of α-lytic protease's amino acid sequence. Unique restriction sites are carefully sought in the degenerate DNA sequence to aid in future mutagenesis studies. The unique restriction sites are designed approximately 50 base pairs apart and their appropriate codons used in the DNA sequence. The codons used to construct the DNA sequence of α-lytic protease are preferred codons in E. coli or used in the production of β-lactam

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23

Franco, Flores Anna Kristyna. "The role of Alpha Beta Hydrolase 6 in the neuronal control of body weight, exercise and anxio-depressive behaviors." Thèse, 2018. http://hdl.handle.net/1866/22143.

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24

Wang, Yi. "Interaction of the third intracellular loop of the a2A-adrenergic [alpha-2A-adrenergic] receptor with the ubiquitin carboxyl-terminal hydrolase L1." 2006. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016696167&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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