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Dissertations / Theses on the topic 'Serine proteinase inhibitors'

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Published: 4 June 2021

Last updated: 12 February 2022

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1

Lauro, Andrea Marie. "The design and synthesis of novel serine proteinase inhibitors." Diss., Georgia Institute of Technology, 1989. http://hdl.handle.net/1853/30032.

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2

Odei-Addo, Frank. "Purification and characterization of serine proteinase inhibitors from two South African indigenous plants, Acacia karoo and Acacia schweinfurthii." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/1291.

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Serine proteases are known to perform a wide range of functions essential to life; however there has to be some form of control mechanism in place. One of the many control mechanisms is their specific inhibition by protein proteinase inhibitors. Proteinase inhibitors in plants, present in their seeds, participate in defense mechanisms and their production is induced by herbivory or wounding. Plant proteinase inhibitors have been reported to inhibit a variety of serine proteinases, including enzymes of the blood coagulation cascade. In this study, various indigenous seed extracts were screened

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3

Sigle, Leah T. "Kazal-type serine proteinase inhibitors in the midgut of Phlebotomus papatasi." Thesis, Kansas State University, 2011. http://hdl.handle.net/2097/13140.

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Master of Science<br>Department of Entomology<br>Marcelo Ramalho-Ortigao<br>Sand flies (Diptera:Psychodidae) are vectors of parasites of the genus Leishmania transmitted to suitable vertebrate host during blood feeding. For blood feeding arthropods, including sand flies, blood meal digestion requires the secretion of inhibitory molecules, such as Kazal-type serine proteinase inhibitors that are involved in preventing the blood from coagulating within the mouthparts and the midgut. Previous studies have identified such molecules in mosquitoes, ticks, and triatomine bugs. Following studies of th

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4

Tehrani, Kamin A. "Synthesis and kinetics of cysteine proteinase inhibitors." Thesis, Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/26967.

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5

Kerrigan, John Edward. "I Uses of enol ethers in asymmetric synthesis : II Isocoumarin mechanism-based inhibitors of serine proteases." Diss., Georgia Institute of Technology, 1991. http://hdl.handle.net/1853/30004.

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6

Wharry, Thomas Scott. "The synthesis of novel phosphonate and phosphinate inhibitors of proteinase enzymes." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263577.

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7

Sin, Suk-fong, and 冼淑芳. "Characterization of proteinase inhibitor II from Solanum Americanum." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B38628776.

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8

Van, Gent Diana. "Evolution of serine proteinase inhibitors and gene expression of Î±-1-antitrypsin." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408668.

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9

Mokoena, Tinyiko. "Establishment of a transformation procedure to study the role of trypsin inhibitors in soybean." Diss., University of Pretoria, 2010. http://hdl.handle.net/2263/27206.

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The major serine proteinase inhibitors Kunitz and Bowman-Birk-type trypsin are key anti-nutrients responsible for the low nutritional value of raw soy cake, the by product of oil expression from soybean. Traditionally, proteinase inhibitors are eliminated from soy cake through intensive heating, which is highly costly. The long term goal is to generate soybean seeds devoid of trypsin inhibitors through tissue culture and genetic modification of soybean. The RNAi technology has been selected in this study as a technique for down-regulation or silencing these two major serine trypsin inhibitors.

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10

Sidhar, Sanjiv Kumar. "The molecular pathology of serine proteinase inhibitors : secretion of novel genetically engineered variants of human a1-antitrypsin." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.745456.

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11

Nadalini, Larissa Cristina Deppmann. "Caracterização do mecanismo adaptativo de Spodoptera frugiperda aos inibidores de proteinase de plantas." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-07022008-151221/.

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A existência de uma família gênica diversa de serino proteinases em Lepidóptera sugere que essas proteinases desempenham um papel importante na adaptação desses insetos à presença de inibidores de proteinases vegetais. Essas enzimas têm se revelado estarem envolvidas no processo digestivo de larvas de insetos. Larvas de Spodoptera frugiperda foram alimentadas com uma dieta suplementada com inibidor de proteinase de soja (IPS) e a expressão gênica de proteinases intestinais foi avaliada através de PCR em tempo real. Análises de transcrição anteriores mostraram a existência de dois grupos de ser

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12

Junior, Osmar Aparecido Theodoro. "Efeito do inibidor de proteinase de origem vegetal EcTI, sobre a lesão pulmonar induzida pela elastase em camundongos C57BI6." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5165/tde-04082014-090830/.

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Introdução: As proteinases tem um papel importante no desenvolvimento, na destruição tecidual e na produção de muco causada pela DPOC. O inibidor de proteinase de origem vegetal Enterolobium contortisiliquum Tripsin Inhibitor (EcTI) inibe tanto as proteinases da classe serina quanto da classe cisteína. Objetivos: Avaliar os efeitos do tratamento com EcTI nas alterações pulmonares induzidas pela elastase em camundongos. Métodos: Camundongos C57Bl6 receberam elastase via intratraqueal (50 uL/animal, grupo ELA) ou salina (grupo SAL). Os camundongos foram tratados com EcTI (2mg/kg) nos dias 1, 15

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13

Gremski, Luiza Helena [UNIFESP]. "Análise do transcriptoma da glândula produtora de veneno de Loxosceles intermedia (aranha marrom): perfil de expressão e identificação de novas toxinas." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/8930.

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Made available in DSpace on 2015-07-22T20:49:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-07-28<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Aranhas do gênero Loxosceles, são responsáveis por acidentes em todo o mundo, com grande importância clínica no Sul do Brasil. Os venenos destas aranhas são compostos por diversas toxinas, entre elas proteínas, responsáveis pelo quadro conhecido como loxoscelismo. No intuito d

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14

Kraunsoe, James A. E. "Inhibitors of serine proteinases." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318814.

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15

Leung, Donmienne Doen Mun. "Studies of serine and cysteine protease inhibitors /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16491.pdf.

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16

Rukamp, Karrie Eileen Adlington. "Design and synthesis of inhibitors for serine and cysteine proteases." Diss., Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04082004-180343/unrestricted/rukamp%5Fkarrie%5Fe%5Fa%5F200312%5Fphd.pdf.

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17

Rukamp, Brian John. "Design, synthesis, and evaluation of novel thiobenzyl ester substrates and aza-peptide inhibitors for serine and cysteine proteases." Diss., Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04072004-180202/unrestricted/rukamp%5Fbrian%5Fj%5F200312%5Fphd.pdf.

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18

Tierney, Marcus John 1973. "Post-transcriptional regulation of plasminogen activator inhibitor type 2." Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/8496.

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19

Huang, Kui. "Structural studies of the interactions between serine proteinases and protein inhibitors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1995. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22151.pdf.

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20

Sin, Suk-fong. "Characterization of proteinase inhibitor II from Solanum Americanum." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/HKUTO/record/B38628776.

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21

Inglis, John Dugald. "The structure and evolution of a rodent serine proteinase inhibitor gene complex." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/18982.

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22

Bacon, Louise. "Molecular biological approaches to the analysis of C1-inhibitor function." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243019.

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23

Devlin, Glyn L. "The mechanisms of serpin misfolding and its inhibition." Monash University, Dept. of Biochemistry and Molecular Biology, 2003. http://arrow.monash.edu.au/hdl/1959.1/9469.

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24

Kruger, Sarah Jane, and n/a. "Characterisation of Proteins from Grevillea robusta and NMR Studies of the Serine Protease Inhibitor." Griffith University. School of Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040618.150708.

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Proteins that recognise the sugar surface structures on cells have an enormous potential to be used as tools in the characterisation of these structures. A group of proteins, called lectins, have been identified that can bind to carbohydrate complexes on the receptors of cells. The crude extract from Grevillea robusta seeds was found to contain lectin-like proteins that were different from most other lectins, as they would specifically target the receptors of white blood cells and not those found on red blood cells. Therefore, the lectin isolated from G.robusta could be used as a tool to id

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25

elMasry, Nadia Farida. "Folding studies on mutants of Chymotrypsin Inhibitor 2." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309338.

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26

Brown, Audra Denise. "α-aminoalkylphosphonate di(chlorophenyl) esters as inhibitors of serine proteases : Part II: A kinetic study of the coupling of the hydrolysis product of the N-tosylalanine ester of 5-phenyl-3-hydroxypyrrole to various diazonium salts : Part III: Rates of thrombin acylation and deacylaton upon reaction with low molecular weight acylating agents, carbamylating agents and carbonylati". Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/27552.

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27

Butler, David Christopher. "The role of Id2 phosphorylation at serine 5 in C2C12 myoblasts." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5669.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains v, 42 p. : ill. (some col.). Includes abstract. Includes bibliographical references.

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28

Koulouris, Chloe Rose. "Identification and characterisation of a novel inhibitor of serine racemase through a fragment-based drug discovery strategy." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/75370/.

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29

Arruda, Ligia Hansen. "Caracterização estrutural da interação de serino proteinases de Spodoptera frugiperda (Lepidoptera: Noctuidae) e inibidores de proteinases de plantas." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-24052011-091301/.

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As plantas desenvolveram diferentes mecanismos para reduzir o ataque de insetos, incluindo compostos protéicos de defesa, como os inibidores de proteinases (IPs). Os insetos, ao longo da evolução, desenvolveram estratégias para superar as barreiras defensivas das plantas, permitindo a sua alimentação e desenvolvimento, como a super expressão de genes de enzimas digestivas sensíveis e insensíveis aos IPs de plantas. Uma das abordagens desse trabalho foi identificar novas serinoproteinases no intestino de lagartas de Spodoptera frugiperda. Duas novas quimotripsinas e trê novas tripsinas foram id

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30

Reis, Rafael de Almeida dos. "Efeito do inibidor de proteinase de origem vegetal BbCI, sobre a lesão pulmonar induzida pela elastase em camundongos C57BI6." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5165/tde-02062014-095433/.

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Introdução: As proteinases tem um papel importante no desenvolvimento, na destruição tecidual e na produção de muco causada pela DPOC. O inibidor de proteinase de origem vegetal Bauhinia bauhinioides Cruzipain Inhibitor (BbCI) inibe tanto as proteinases da classe serina quanto da classe cisteína. Objetivos: Deste modo consideramos relevante estudar os efeitos do tratamento com BbCI nas alterações pulmonares induzidas pela elastase em camundongos. Métodos: Camundongos C57Bl6 receberam elastase via intratraqueal (50 uL/animal, grupo ELA) ou salina (grupo SAL). Os camundongos foram tratados com B

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31

ROUCHON, PASCALE. "Inhibiteurs de masse moleculaire elevee des cysteine et des serine proteinases du muscle squelettique de bovin : purification et caracterisation physicochimique et cinetique." Clermont-Ferrand 2, 1995. http://www.theses.fr/1995CLF21728.

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Six inhibiteurs de proteinases ont ete isoles a partir du muscle squelettique de bovin et leurs caracteristiques physico-chimiques ont ete etudies. Trois d'entre eux, nommes pi1, pi2 et pi3 (pour papaine inhibiteur 1, 2, 3) sont specifiques des cysteine proteinases lysosomales. Ils ont des masses moleculaires respectives de 43, 69 et 61 kda. Pi1 et pi2 sont extremement stables au ph et a la temperature alors que l'activite de pi3 diminue significativement aux ph acides (inferieur a 6) et aux temperatures superieures a 50c. Les trois inhibiteurs ont peu d'effet sur la cathepsine b. Par contre i

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32

Zu, Yi. "SIRT1 promotes cell proliferation and prevents cellular senescence through targeting LKB1 in primary porcine aortic endothelial cells." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085805.

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33

Zu, Yi, and 祖毅. "SIRT1 promotes cell proliferation and prevents cellular senescence through targeting LKB1 in primary porcine aortic endothelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085805.

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34

Beton, Daniela. "Caracterização molecular de INc-1, um inibidor da proteína fosfatase do tipo 1 de neurospora crassa." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-11112014-173834/.

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A proteína serina/treonina fosfatase do tipo 1 (PP1) é a principal serina/treonina fosfatase envolvida na regulação de diversos processos tais como metabolismo, crescimento e divisão celular, síntese protéica e processamento de RNA. A holoenzima PP1 é constituída de uma subunidade catalítica conservada (PP1c) e subunidades reguladoras variáveis. Em mamíferos já foram identificados dezenas de polipeptídeos que associam-se direta ou indiretamente a PP1c, gerando holoenzimas com localizações celulares e especificidades distintas. Entre as proteínas que se associam a PP1c, muitas têm função inibit

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35

Goodman, Alan Gabriel. "P58IPK, the cellular eIF2alpha kinase inhibitor, promotes viral mRNA translation and limits host death during influenza virus infection /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8082.

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36

Duran, Adriana Feliciano Alves. "Efeito dos inibidores de serinoproteases rBmTI-A e rBmTI-6 em modelo de enfisema pulmonar em camundongos e em linhagem de células epiteliais pulmonares A549." reponame:Repositório Institucional da UFABC, 2018.

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Orientador: Prof. Dr. Sergio Daishi Sasaki<br>Tese (doutorado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biossistemas, São Bernardo do Campo, 2018.<br>A doença pulmonar obstrutiva crônica é uma doença caracterizada por progressiva limitação do fluxo aéreo e suas principais manifestações são a bronquite crônica e o enfisema pulmonar. O quadro é geralmente irreversível e engloba uma série de processos que incluem a resposta inflamatória anormal dos pulmões com participação ativa de macrófagos, neutrófilos e linfócitos, a falha na reparação de células anormais, a apoptose precoc

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37

Chen, Ting, and 陳婷. "Structural and Functional Studies of Human Kazal-Type Serine Proteinase Inhibitors." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/66972556867684892060.

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38

"Isolation and characterization of chymotrypsin inhibitor and trypsin inhibitors from seeds of momordica cochinchinensis." 2000. http://library.cuhk.edu.hk/record=b5890258.

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by Ricardo Wong Chi Ho.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2000.<br>Includes bibliographical references (leaves 128-138).<br>Abstracts in English and Chinese.<br>Acknowledgments --- p.i<br>Abstract --- p.ii<br>論文摘要 --- p.iv<br>Table of Contents --- p.vi<br>List of Figures --- p.xi<br>List of Tables --- p.xiii<br>List of Abbreviations --- p.xiv<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Overview of Serine Protease Inhibitors --- p.1<br>Chapter 1.2 --- Classification of Serine Protease Inhibitors --- p.2<br>Chapter 1.2.1 --- Kunitz Type Serine P

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39

Lin, Chih-Che, and 林志哲. "The Immunomodulatory Effect of Calamitas Urinae Hominis and Serine Proteinase Inhibitors on Repetitive Dermatogoides -pteronyssinus Challenged Asthmatic Mice Model." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/9p9gfz.

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博士<br>中國醫藥大學<br>中醫學系博士班<br>102<br>Allergic asthma is a chronic airway inflammatory disease. Mild and moderate asthma is characterized by the Th2-bios immune response, which can induce eosinophil infiltration、mast cell activation、epithelial hypertrophy、goblet cell hyperplasia、airway hyperresponsiveness and excessive mucus secretion in airway. However, severe asthma is corticosteroid resistance associated with neutrophilic inflammation, which is related to Th17 cells immue response. Dermatogoides pteronyssinus （Der p）is one of the most prominent and important species of house dust mite to induce

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40

Lin, Chia-Wei, and 林家偉. "Cloning and functional analysis of serine proteinase inhibitor of Cucumis metuliferus." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/64136188385584640396.

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博士<br>國立中興大學<br>農藝學系所<br>103<br>Proteinase inhibitors (PIs) is an ubiquitous protein involved in physiology reaction, biotic and abiotic stress defense responses via block the active center or allosteric interaction with specific proteinase. In this study, we cloned Cucumis metuliferus serine PI (CmSPI) gene, a potato I type PIs, from horned melon (C. metuliferus) papaya ringspot virus (PRSV) resistant line PI 292190. A core abscisic acid response element, a T/GBOXATPIN2 element, and a wound response element were identified on the promoter region of CmSPI indicating its role in plant stress re

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41

Morty, Rory Edward. "A serine oligopeptidase from African Trypanosomes." Thesis, 1998. http://hdl.handle.net/10413/9778.

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Protozoan parasites of the genus Trypanosoma are responsible for chronic and widespread disease in livestock and humans in Africa. This study describes the purification and characterisation of a serine oligopeptidase from Trypanosoma brucei brucei and from T. congolense. Serine peptidase activity has previously been described for T. b. brucei although the responsible enzyme was not purified to electrophoretic homogeneity. In the present study this enzyme was purified from bloodstream-form T. b. brucei by a combination of three-phase partitioning, ion-exchange, affinity and molecular exclusion

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42

Oji, Melody Enyinna [Verfasser]. "Expression von Serin-Proteinase-Inhibitoren in der Haut : Vergleich von Netherton Syndrom mit Psoriasis vulgaris and atopischer Dermatitis / vorgelegt von Oji, Melody Enyinna." 2005. http://d-nb.info/974871648/34.

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43

Fan, Li. "mTOR regulates Aurora A via enhancing protein stability." Thesis, 2014. http://hdl.handle.net/1805/4648.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Mammalian target of rapamycin (mTOR) is a key regulator of protein synthesis. Dysregulation of mTOR signaling occurs in many human cancers and its inhibition causes arrest at the G1 cell cycle stage. However, mTOR’s impact on mitosis (M-phase) is less clear. Here, suppressing mTOR activity impacted the G2-M transition and reduced levels of M-phase kinase, Aurora A. mTOR inhibitors did not affect Aurora A mRNA levels. However, translational reporter constructs showed that mRNA containing a short, simple 5’-untranslated region (UTR), r

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44

Rybáriková, Renata. "Rekombinantní exprese a funkční charakterizace rostlinných Kunitzových inhibitorů." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-449050.

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PDI ("potato cathepsin D inhibitor ") and NID ("novel inhibitor of cathepsin D ") from potato (Solanum tuberosum) belong to the protein family of Kunitz inhibitors (I3 family, Merops database). These 20 kDa isoinhibitors with the typical β-trefoil architecture inhibit aspartic and serine peptidases. In this thesis, the constructs for recombinant expression of PDI and NID in the yeast Pichia pastoris system were prepared and high-producing colonies were selected. Both proteins were identified in the cultivation media by mass spectrometry and N-terminal sequencing. A purification protocol for PD

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45

Chawla, Aarti R. "CaMKII regulation of astrocytic glutamate uptake." Diss., 2016. http://hdl.handle.net/1805/10605.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Glutamate clearance by astrocytes is an essential part of physiological excitatory neurotransmission. Failure to adapt or maintain low levels of glutamate in the central nervous system is associated with multiple acute and chronic neurodegenerative diseases. The primary excitatory amino acid transporters (EAATs) in human astrocytes are EAAT1 and EAAT2 (GLAST and GLT-1 respectively in rodents). While the inhibition of a ubiquitously-expressed serine/threonine protein kinase, the calcium/calmodulindependent kinase (CaMKII) result

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46

Kickstein, E., S. Krauss, P. Thornhill, et al. "Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling." 2010. http://hdl.handle.net/10454/6051.

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Hyperphosphorylated tau plays an important role in the formation of neurofibrillary tangles in brains of patients with Alzheimer's disease (AD) and related tauopathies and is a crucial factor in the pathogenesis of these disorders. Though diverse kinases have been implicated in tau phosphorylation, protein phosphatase 2A (PP2A) seems to be the major tau phosphatase. Using murine primary neurons from wild-type and human tau transgenic mice, we show that the antidiabetic drug metformin induces PP2A activity and reduces tau phosphorylation at PP2A-dependent epitopes in vitro and in vivo. This tau

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