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Journal articles on the topic 'Seromucinous'

Author: Grafiati

Published: 7 June 2025

Last updated: 16 July 2025

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1

Orazov, Mekan R., Marina V. Kiseleva, and Vladlena M. Pernay. "Pathogenesis of ovarian seromucinous borderline tumors." Clinical review for general practice 5, no. 7 (2024): 74–82. http://dx.doi.org/10.47407/kr2024.5.7.00p425.

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he 2014 World Health Organization classification identifies ovarian seromucinous tumors as one of the six categories of epithelial ovarian tumors. Ovarian seromucinous tumors encompass adenomas, atypical proliferating (borderline) tumors, and invasive carcinomas. These tumors are exceedingly rare, with benign instances accounting for a mere 1% and 25% of borderline cases among all atypical proliferating tumors. The rarity of seromucinous cancer means its prevalence has not been thoroughly investigated, which has resulted in this group of tumors remaining incompletely researched.

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2

Taylor, Jennifer, and W. Glenn McCluggage. "Ovarian Seromucinous Carcinoma." American Journal of Surgical Pathology 39, no. 7 (2015): 983–92. http://dx.doi.org/10.1097/pas.0000000000000405.

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3

Huang, Yu-Wen, Ying-Ju Kuo, Ching-Yin Ho, and Ming-Ying Lan. "Sinonasal seromucinous hamartoma." European Archives of Oto-Rhino-Laryngology 275, no. 3 (2018): 743–49. http://dx.doi.org/10.1007/s00405-018-4885-8.

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4

Suresh, Aiswarya. "Seromucinous Hamartoma of Nasal cavity : A Rare Case Report." Bengal Journal of Otolaryngology and Head Neck Surgery 30, no. 2 (2023): 270–73. http://dx.doi.org/10.47210/bjohns.2022.v30i2.768.

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Introduction :Seromucinous hamartoma is a rare benign lesion of the sinonasal tract, composed of proliferation of seromucinous glands and ducts within a variable fibrous stroma.Case Report :This report is about a 58 year old female patient who presented with a fleshy mass extending upto the floor of the left nasal cavity. After its endoscopic excision, histopathological examination revealed a seromucinous hamartoma which was confirmed by immunohistochemistry.Discussion: Seromucinous hamartoma is a rare entity of the nasal cavity which arise on the septum or nasopharynx and rarely from lateral wall and sinuses. 19 cases have been reported world wide so far. Hence a correct diagnosis, based on histopathological study along with immunohistochemistry is necessary for appropriate and accurate management. Early intervention with surgery and radiotherapy is required to avoid recurrence.

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5

Nakamura, Eriko, Yuichiro Sato, Sayaka Moriguchi, Atsushi Yamashita, Takashi Higo, and Yujiro Asada. "Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination." Case Reports in Obstetrics and Gynecology 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/690891.

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Ovarian seromucinous borderline tumors (SMBTs) are rare. They architecturally resemble serous borderline tumors but are much more frequently associated with endometriosis. The coexistence of other tumors with seromucinous tumors is also extremely rare. Here, we report an unusual combination of bilateral ovarian SMBT and clear cell carcinoma associated with polypoid endometriosis of the colon, in a 62-year-old woman. There was no transitional lesion between the two tumors. Immunohistochemistry showed different staining patterns in tumor components. Seromucinous tumor cells were positive for estrogen receptor (ER) and progesterone receptor (PgR) but negative for Napsin A, p504S, and HNF1B. Clear cell tumor cells were positive for Napsin A and p504S and focally positive for HNF1B but negative for ER and PgR. Loss of ARID1A expression was not observed in SMBTs, clear cell tumors, or endometriosis. These findings suggest that these tumors arose from separate endometriosis foci and collided within the same ovary. To the best of our knowledge, this is the first case of this unusual combination of ovarian seromucinous tumor and clear cell carcinoma to be reported in the English literature.

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6

Basiari, Lentiona, Maria Michali, Ioannis Komnos, Georgios Tsirves, Victoria Tsoumani, and Ioannis Kastanioudakis. "Seromucinous Hamartoma of the Lateral Nasal Wall with Infiltration of the Orbit: A Rare Case Report and Review of the Literature." Case Reports in Otolaryngology 2023 (August 12, 2023): 1–5. http://dx.doi.org/10.1155/2023/1923015.

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Seromucinous hamartoma is a rare benign glandular proliferation arising from the respiratory epithelium of the sinonasal tract and nasopharynx. It was described for the first time in 1974 by Baillie and Batsakis. Since then, few cases have been reported in the literature with most of them occurring in the posterior nasal septum. We report the case of a 52-year-old woman that presented to our department with left periorbital edema, pain, and dacryorrhea due to seromucinous hamartoma arising from the left inferior turbinate and extending through the lateral nasal wall into the maxilla, the nasolacrimal duct, and the orbit. Endoscopic medial maxillectomy and endoscopic transnasal orbital tumor resection were performed. The patient remains symptom-free for 16 months, till her most recent follow-up. Seromucinous hamartoma of the nasal cavity is an exceedingly rare diagnosis, especially in the lateral nasal wall. It should be included in the differential diagnosis of nasal tumors. According to the literature review, this is the first case report of seromucinous hamartoma with orbit infiltration. Endonasal endoscopic resection is the treatment of choice.

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7

Nagamine and Mikami. "Ovarian Seromucinous Tumors: Pathogenesis, Morphologic Spectrum, and Clinical Issues." Diagnostics 10, no. 2 (2020): 77. http://dx.doi.org/10.3390/diagnostics10020077.

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Ovarian seromucinous tumors were introduced in the 2014 World Health Organization (WHO) classification as one of the seven types of ovarian epithelial tumors. They are characterized by frequent association with endometriosis and bilaterality, microscopic appearance of papillary architecture, and admixture of a variety of müllerian-type epithelium. They are considered to be endometriosis-related ovarian neoplasms, along with endometrioid and clear cell tumors; recent molecular studies suggest this particular tumor is a variant of endometrioid tumor. Discrepancies in nomenclature, definition, and morphology of seromucinous tumors appear to be a source of confusion, for both clinicians and general surgicalpathologists. This review summarizes the clinicopathological features of benign, borderline, and malignant seromucinous tumors, as well as controversies regarding these tumors.

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8

Goyal, Anjali, Zil Ashokkumar Kuntar, Prahari Nayankumar Updhyaya, Monali Rameshbhai Halpati, and Kinjal Kalsinh Damor. "Borderline seromucinous tumor with pre-existing endometriosis - A case report." IP Journal of Diagnostic Pathology and Oncology 9, no. 2 (2024): 130–33. http://dx.doi.org/10.18231/j.jdpo.2024.026.

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The ovary is a common location for endometriosis, characterized by the presence of endometrial glands outside the uterus. Research has established a link between ovarian endometriosis and the coexistence of borderline seromucinous tumors, which have a low malignant potential and exhibit papillary structures similar to serous borderline tumors. We present a case study of a unmarried, 23-year-old female who experienced spotting, pelvic pain, weakness, and fatigue for a month. Ultrasound examination revealed an enlarged and multiloculated ovary with elevated CA-125 levels. Following a right-sided oophorectomy, histopathological analysis confirmed the diagnosis of borderline seromucinous tumor accompanied by endometriosis. This case supports the finding that borderline seromucinous tumors can occur simultaneously or subsequently with ovarian endometriosis

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9

Erkiliç, Suna, Abdullah Aydin, and N. Emrah Koçer. "Histological features in routine tonsillectomy specimens: the presence and the proportion of mesenchymal tissues and seromucinous glands." Journal of Laryngology & Otology 116, no. 11 (2002): 911–13. http://dx.doi.org/10.1258/00222150260369435.

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Tonsillectomy is a frequently performed operation but there is little information about the histological features of a tonsillectomy specimen. In this study, we re-evaluated archival materials of 1220 cases who underwent tonsillectomy because of hyperplastic tonsils. Haematoxylin and eosin sections of the cases were re-examined and the presence and the proportion of mesenchymal tissues (skeletal muscle, cartilage, fat, bone) and seromucinous glands were noted as focal, multifocal or abundant. The incidence of skeletal muscle was 89 per cent (1085 cases; 206 focal, 465 multifocal, 414 abundant), seromucinous glands 35 per cent (429 cases; 236 focal, 134 multifocal, 59 abundant), fat 21 per cent (251 cases; 208 focal, 43 multifocal), cartilage three per cent (31 cases), and bone one per cent (seven cases). Also in 165 cases (14 per cent) skeletal muscle, in 12 cases (one per cent) was seromucinous glands, in eight cases (one per cent) was cartilage, in seven cases (one per cent) fat, and in four cases (less than one per cent) bone were found between hyperplastic lymphoid tissue. It can be concluded that mesenchymal tissues (skeletal muscle, cartilage, fat, bone) and seromucinous glands may be seen in different proportions in routine tonsillectomy specimens.

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10

Sethia, Madhuri, Bushra Siddiqui, Surabhi Gautam, and Veena Maheshwari. "Seromucinous carcinoma of ovary - A rare entity." Indian Journal of Pathology and Oncology 10, no. 3 (2023): 317–20. http://dx.doi.org/10.18231/j.ijpo.2023.071.

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Ovarian epithelial tumours are common tumors of female genital tract and they account for vast majority of female ovarian neoplasms. ovarian seromucinous carcinomas (OSMC) are rare ovarian tumours containing serous and endocervical mucinous type cells. In 2020, World Health Organization Classification of Female Genital Tumors recategorized seromucinous ovarian carcinomas as ovarian endometrioid carcinoma with mucinous differentiation. Most OSMC present in stage I or II and have a favourable prognosis.We present the case of a 30-year-old female who presented with complaints of lower abdominal pain and abdominal distension. Contrast enhanced computed tomography of abdomen suggested a left sided malignant adnexal mass following which Left sided salpingo-oophorectomy was performed and histopathological examination and immunohistochemistry of specimen was done and a diagnosis of left ovarian seromucinous carcinoma was rendered.

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11

Thanka, J., Divya Dinesh, Vinutha Gali, and Ajitha Rajalingam. "Seromucinous tumors of ovary: A case series." Indian Journal of Pathology and Oncology 11, no. 2 (2024): 166–71. http://dx.doi.org/10.18231/j.ijpo.2024.035.

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Seromucinous neoplasms are new category of ovarian epithelial tumor in the 2014 revised World Health Organization classification. Surface epithelial neoplasms are the most common ovarian tumors. Based on the degree of stratification and the presence or absence of invasion, these epithelial proliferations are further divided into benign, borderline, and malignant categories. Benign tumors are divided into three subtypes: cystadenoma (cystic areas), cystadenofibroma (cystic and fibrous areas), and adenofibroma (predominantly fibrous sections). Serous adenofibromas are rare variant of serous surface epithelial tumors. They affect females between the ages of 15 and 65 and make up 1.7% of all benign ovarian tumors. Serous tumor with a solid, fibrous component is designated as serous cystadenofibroma in which both serous and mucinous components are closely intermixed. Seromucinous adenofibroma is a benign cystic neoplasm composed of glands and cysts lined by an admixture of bland mullerian type epithelium which includes ciliated, endocervical type mucinous, and endometroid. They have a characteristic prominent fibromatous hypocellular stroma which helps differentiate it from the commoner cystadenoma. Seromucinous borderline tumors is 10% -20% of all epithelial ovarian tumors. Develops in younger age, usually bilateral in upto 40%, associated with endometriosis. We discuss about four different cases of seromucinous tumor reported in our institute.

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12

Godse, Neal Rajan, Giuseppe Vittorio Staltari, Katherine Doeden, and Grant Shale Gillman. "Confounding case of seromucinous hamartoma." BMJ Case Reports 14, no. 3 (2021): e240460. http://dx.doi.org/10.1136/bcr-2020-240460.

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A 67-year-old man presented with progressive diplopia. On evaluation, he was noted to have bilateral palsies of cranial nerves III, IV and VI as well as a unilateral right true vocal fold paralysis. CT and MRI studies demonstrated a T2-bright left ethmoid mass with no evidence of bony erosion. Direct visualisation demonstrated a polypoid appearing mass of the left sphenoethmoid recess. Operative biopsy was pursued with final pathology demonstrating benign seromucinous hamartoma. Subsequent blood work demonstrated high titres of anti-acetylcholine receptor antibodies consistent with myasthenia gravis. The patient was started on pyridostigmine with improvement in his ocular cranial neuropathies.

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13

Lee, Dong Hoon, Tae Mi Yoon, Joon Kyoo Lee, and Sang Chul Lim. "Seromucinous hamartoma of inferior turbinate." Medicine 97, no. 45 (2018): e13022. http://dx.doi.org/10.1097/md.0000000000013022.

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14

Shrestha Prajapati, Sristee, Anisha Shrestha, and Usha Bade Shrestha. "Rare Presentation of Giant Ovarian Cyst." Journal of Nepal Health Research Council 19, no. 04 (2022): 849–51. http://dx.doi.org/10.33314/jnhrc.v19i04.3851.

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A 32-year-old unmarried female on an atypical antipsychotic presented with massive abdominal distension and progressive difficulty in breathing and ambulation. Imaging revealed a giant ovarian mass originating on the right side. A fertility sparing laparotomy was carried out, without complication. Histopathological evaluation revealed a seromucinous cystadenoma. Giant ovarian cysts are seldom encountered in current medical practice secondary to easy availability of imaging modalities and treatment facilities. In spite of their considerable size, such tumors are usually benign and have a good prognosis. Keywords: Fertility sparing laparotomy; giant ovarian cysts; Seromucinous cystadenomas.

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15

Altman, Kenneth W., Joshua D. Waltonen, Neal D. Hammer, James A. Radosevich, and G. Kenneth Haines. "Proton Pump (H+/K+-ATPase) Expression in Human Laryngeal Seromucinous Glands." Otolaryngology–Head and Neck Surgery 133, no. 5 (2005): 718–24. http://dx.doi.org/10.1016/j.otohns.2005.07.036.

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OBJECTIVE: Recent pilot research suggested that the H+/K+-ATPase (proton pump), which is the target of pharmacotherapy for laryngopharyngeal reflux disease (LPRD), is associated with human laryngeal submucosal glands. The hypothesis of this study is that proton pump is expressed in the human larynx, and is not solely associated with the parietal cells of the stomach. METHODS: Fifteen surgical larynx subjects (27 pathologic specimens) containing seromucinous glands from banked tissue were retrospectively obtained after approval from Human Subjects Committee. Banked human stomach tissue was also obtained for comparative positive and negative controls. Sections were immunostained with two monoclonal antibodies selectively reactive with alpha or beta subunits of the H+/K+-ATPase (proton) pump. RESULTS: In the human larynx, positive staining was seen in 14 of 15 subjects. Twenty-six specimens showed consistent staining in the seromucinous cells and ducts for the alpha subunit, and 23 specimens for the beta subunit. Stomach parietal cells exhibited strongly positive staining for both the alpha and beta subunits of the proton pump. There was no staining in stomach cells that were not morphologically consistent with the parietal cell. CONCLUSION: The H+/K+-ATPase (proton) pump is present in seromucinous cells and ducts in the human larynx, with some variable expression noted. Proton pump involvement in human laryngeal seromucinous glands may explain heightened laryngeal sensitivity in those patients with chronic laryngitis believed to have LPRD. Also, proton pump inhibitor pharmacotherapy may have a site of action in the human larynx, explaining some of the controversies attributable to LPRD.

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16

Baré, Stephen, Yuen Chan, and Hock Kua. "Ovarian seromucinous carcinoma – a case report." Pathology 49 (February 2017): S66. http://dx.doi.org/10.1016/j.pathol.2016.12.161.

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17

Tong, Kimberly N., Renee M. Serra, Robert Y. Shih, and Robert D. Foss. "Seromucinous Hamartoma of the Nasal Cavity." Head and Neck Pathology 13, no. 2 (2018): 239–42. http://dx.doi.org/10.1007/s12105-018-0914-6.

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18

Maksem, John. "Seromucinous borderline tumor-associated high-grade ovarian cancers." Journal of Clinical Obstetrics and Gynecology Research 6, no. 1 (2024): 1–14. http://dx.doi.org/10.52338/jocogr.2024.4006.

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We present 6 high grade ovarian carcinomas that were associated with seromucinous borderline tumors. Patients ranged in age from 26 to 66 years. All cancers appeared as solid regions within otherwise paucicystic tumors that measured from 4.2 cm to 14.0 cm in greatest dimension. Five of the 6 tumors were bilateral, and endometriosis was seen in 4 of the tumors. Clinical data, with follow up periods ranging from 0 to 40 months, was available for all patients. Four patients died of their disease and two had recurrent disease at the time of this review. All tumors exhibited a low-grade carcinoma component, which is consistent with ovarian cancers developing in a progressive adenoma to carcinoma sequence (so-called type I ovarian cancers). Two of the associated low-grade/borderline tumors had focal serous characteristics with WT1+ epithelial cell clustering. High-grade tumors exhibited an array of cell types expressing endometrioid, undifferentiated, serous, clear cell, and mucinous features that were at times mixed within the same tumor. Five cancers were focally WT1+; two showed admixed lowgrade serous features and one showed a high-grade serous adenocarcinoma with transitional features. Two cancers had mucinous features (one with focal CK20 and CDX2 immunohistochemical staining and one only with focal CDX2 immunohistochemical staining). All the high-grade tumors showed a mutated-pattern of p53 nuclear staining with >75% 2-3+ staining. We conclude that seromucinous borderline tumors need to be extensively sampled. Cyst wall membrane rolls are important to evaluate since they may reveal persisting endometriosis and solid regions most likely harbor a high-grade tumor. Identifying high-grade cancer within a seromucinous borderline tumor is important because, although seromucinous borderline tumors and their oftassociated low-grade endometrioid cancers have favorable outcomes, tumors harboring a high-grade component are aggressive and may eventuate in patient death.

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R J, Kishor, Bhuvaneshwari Harikrishnan, Naveen Alexander, and Veena Bheeman. "Extraovarian primary seromucinous cystadenoma masquerading as mesenteric cyst." BMJ Case Reports 14, no. 5 (2021): e240414. http://dx.doi.org/10.1136/bcr-2020-240414.

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We report an interesting case of extraovarian, primary seromucinous cystadenoma, which presented as a mesenteric cyst. A 31-year-old woman came with complaints of lower abdominal pain for 2 years, which is intermittent and aggravated during the menstrual cycle. On examination, her vitals were within normal limits; per abdominal examination revealed 7×7 cm mass in the right lumbar and right hypochondrium with well-defined margins. A Contrast-enhanced whole abdomen done showed a thin-walled of cyst of size 7×8×9 cm in the right lumbar region abutting and replacing the mesenteric border of ascending colon suggesting of mesenteric cyst. Patient underwent laparoscopic excision of mesenteric cyst. Histopathology revealed seromucinous cystadenoma without ovarian stroma.

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20

Novikov, F. V., I. S. Luneva, and O. A. Starkova. "Molecular genetic profile of seromucinous ovarian tumors." Arkhiv patologii 83, no. 1 (2021): 53. http://dx.doi.org/10.17116/patol20218301153.

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21

Liu, Tingting, Daichi Sumida, Takuya Wada, et al. "A diagnostic challenge of seromucinous borderline tumor." Medicine 98, no. 22 (2019): e15707. http://dx.doi.org/10.1097/md.0000000000015707.

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22

Han, Jin Woo, Kyeong Ah Kim, Hye Yoon Chang, et al. "Newly Categorized Seromucinous Tumor of the Ovary." Journal of Computer Assisted Tomography 43, no. 1 (2019): 119–27. http://dx.doi.org/10.1097/rct.0000000000000776.

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23

Evans, C. S. "Seromucinous (salivary) ectopia of the perianal region." Archives of Dermatology 123, no. 10 (1987): 1277. http://dx.doi.org/10.1001/archderm.123.10.1277.

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Evans, Cherie S. "Seromucinous (Salivary) Ectopia of the Perianal Region." Archives of Dermatology 123, no. 10 (1987): 1277. http://dx.doi.org/10.1001/archderm.1987.01660340037014.

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25

NAGAYOSHI, YOKO, KYOSUKE YAMADA, TAKAKO KIYOKAWA, et al. "Clinical Features of Borderline Ovarian Seromucinous Tumor." Cancer Diagnosis & Prognosis 3, no. 3 (2023): 360–64. http://dx.doi.org/10.21873/cdp.10224.

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Background/Aim: Ovarian seromucinous tumor is a histological type of ovarian neoplasm. Although seromucinous borderline tumors (BSMT) are associated with endometriosis, the frequency of their occurrence is low, and many aspects of their behavior remain unclear. In this study, we aimed to clarify the clinicopathological factors of BSMT. Patients and Methods: We retrospectively reviewed 32 patients with pathologically diagnosed BSMT who underwent surgery at Jikei University Hospital. The survey items were patient characteristics, such as age, initial symptoms, preoperative tumor markers, surgical procedure and stage of surgery, presence of endometriosis, and recurrence. Results: The median age was 45 years. Lower abdominal pain was the most common chief complaint, about one-third of patients were asymptomatic; one-sixth were discovered during follow-up for endometriosis. The majority had a high serum CA19-9 level. Twenty-five patients (78.1%) had unilateral masses, whereas seven patients (21.9%) had bilateral masses. More than 90% of the cases had coexisting endometriosis histologically. Thirty cases (93.8%) were stage I, only two were stage II, and none were stage III or IV. Recurrence was observed in two cases: one was borderline malignant and the other was a carcinoma. Conclusion: BSMT is a rare form of borderline malignancy. Its preoperative diagnosis is often difficult because of various clinical findings, but a history of endometriosis and an elevated serum CA19-9 level may aid in some cases.

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Rosenthal, Laura H. Swibel, Michael S. Benninger, Chad H. Stone, and Mark A. Zacharek. "Wound Healing in the Rabbit Paranasal Sinuses after Coblation: Evaluation for use in Endoscopic Sinus Surgery." American Journal of Rhinology & Allergy 23, no. 3 (2009): 360–63. http://dx.doi.org/10.2500/ajra.2009.23.3326.

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Background Bipolar radiofrequency can be used surgically to excise and cauterize tissue simultaneously. It has potential for use in endoscopic sinus surgery (ESS). This study was performed to determine the extent and pattern of injury in the paranasal sinuses with bipolar radiofrequency and evaluate wound healing. Methods Eight rabbits underwent Coblation of maxillary sinus mucosa with biopsy immediately, on postoperative day (POD) 3, 7, 14, or 29. Maxillary mucosa was exposed through the nasal dorsum, and a Coblator PROciseXP wand used on a power setting of 7 for 2 seconds. Three of the rabbits also had Coblation of ethmoid mucosa over the lamina papyracea, after extending the maxillary ostomy, with biopsy immediately. Results Coblation resulted in immediate loss of surface respiratory epithelium and thermal-type injury to the underlying seromucinous glands. On POD 3, the site showed reepithelialization with squamous metaplastic epithelium. The seromucinous glands underwent coagulative necrosis. At POD 7, there was partial replacement of overlying epithelium by respiratory epithelium. The underlying seromucinous glands were lost and replaced by fibroblastic proliferation, with less fibrosis than the mechanically created ostomy site. The underlying bone had reactive, regenerative changes. On PODs 14 and 29, there was further regeneration of respiratory epithelium. Fibrosis was mild. Coblation resulted in gross violation of the bony wall in one maxillary sinus. There were no histological changes in the orbit. Conclusion Rabbit paranasal sinus mucosa heals appropriately after Coblation injury.

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Betsuyaku, Tsubasa, Toshinori Nishizawa, Naofumi Higuchi, and Satoki Misaka. "Trousseau’s syndrome associated with an ovarian borderline tumour." BMJ Case Reports 14, no. 8 (2021): e244249. http://dx.doi.org/10.1136/bcr-2021-244249.

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A 71-year-old woman was admitted to our hospital because of sudden onset of weakness on the left side of her body. Her medical history was unremarkable, and on physical examination, hemiparesis and hyperreflexia on the left side were found. MRI of the brain showed multiple areas of restricted diffusion in both parietal lobes and in the cerebellum, consistent with embolic shower. Magnetic resonance angiography showed no abnormal findings. A contrast-enhanced CT scan revealed multiple pulmonary emboli. Abdominal MRI showed a 135 mm left ovarian tumour composed of a solid and a cystic component with liquid level formation. After a total hysterectomy and bilateral adnexectomy, the histopathology confirmed a seromucinous borderline tumour. Therefore, the patient was diagnosed with Trousseau’s syndrome associated with an ovarian seromucinous borderline tumour. To our knowledge, this is the first report mentioning a borderline ovarian tumour detected as Trousseau’s syndrome.

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Chiaffarino, Francesca, Fabio Parazzini, Matteo Surace, Guido Benzi, Vito Chiantera, and Carlo La Vecchia. "Diet and risk of seromucinous benign ovarian cysts." European Journal of Obstetrics & Gynecology and Reproductive Biology 110, no. 2 (2003): 196–200. http://dx.doi.org/10.1016/s0301-2115(03)00115-5.

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Figures, Mindy R., Jayakar V. Nayak, Carl Gable, and Alexander G. Chiu. "Sinonasal seromucinous hamartomas: Clinical features and diagnostic dilemma." Otolaryngology–Head and Neck Surgery 143, no. 1 (2010): 165–66. http://dx.doi.org/10.1016/j.otohns.2009.11.014.

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30

Kurman, Robert J., and Ie-Ming Shih. "Seromucinous Tumors of the Ovary. What’s in a Name?" International Journal of Gynecological Pathology 35, no. 1 (2016): 78–81. http://dx.doi.org/10.1097/pgp.0000000000000266.

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Shamarakova, Shamarakova M. V., Adamyan L. V. Adamyan, Asaturova A. V. Asaturova, et al. "Seromucinous ovarian tumors and endometriosis in reproductive-aged wo." Akusherstvo i ginekologiia 7_2018 (August 3, 2018): 84–91. http://dx.doi.org/10.18565/aig.2018.7.84-91.

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32

Berenson, Abbey B., D. Keith Edmonds, and John Pryse-Davies. "Seromucinous cystadenoma in a true hermaphrodite: A case report." Adolescent and Pediatric Gynecology 6, no. 1 (1993): 36–38. http://dx.doi.org/10.1016/s0932-8610(12)80121-6.

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Scholz, Bettina, Manuela Beckert, Volker Mordstein, Nora Hohmann, Reimund Walther, and Thomas Papadopoulos. "Seromucinous borderline tumor of the testis—A case report." Human Pathology 60 (February 2017): 188–91. http://dx.doi.org/10.1016/j.humpath.2016.06.023.

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34

Elwany, Samy, Ayman Moustafa Al-Medany, Hoda Mahmoud Khalifa, Sedik Abdel Salam, Ahmed Soliman, and Osama Abu El-Kheir. "The nasal seromucinous glands after endoscopic sphenopalatine artery coagulation." European Archives of Oto-Rhino-Laryngology 266, no. 9 (2009): 1417–22. http://dx.doi.org/10.1007/s00405-009-0917-8.

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35

Patrascu, Elena, Vlad Budu, and Gabriela Musat. "Nasal swell body: a literature review." Romanian Journal of Rhinology 10, no. 37 (2020): 19–23. http://dx.doi.org/10.2478/rjr-2020-0004.

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AbstractThe nasal swell body (NSB) is considered to be an enlarged region of the nasal septum, which is located superiorly to the inferior nasal turbinate and anteriorly to the middle nasal turbinate, with a potential effect upon the airflow nasal valve. The histological studies of the NSB demonstrated that it is a glandular formation, not a venous structure, and it is formed by septal cartilage and bone, as well as a thick mucosa. Recent studies emphasized the functional role of the nasal swell body and it is thought to interfere with the nasal airflow and air humidification, due to its proximity to the internal nasal valve and its histological characteristics (venous sinusoids and seromucinous glands). The nasal swell body is strongly related to the presence of rhinosinusal chronic inflammations (allergic rhinitis and chronic rhinosinusitis) and the septal deviation. In case of the presence of the nasal swell body, surgical treatment is not commonly done, due to the absence of a consensus between the ENT practitioners. Most of them consider surgery as being too aggressive because of the presence of seromucinous glands, with slight impact upon the nasal obstruction. Most probably, the lack of consensus is determined by inconsistent anatomical and histological study results.

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Alokby, Ghassan, Rawan S. Alayed, and Jude B. Al Fayez. "Seromucinous hamartoma of ethmoid sinus in pediatric patient (case report)." International Journal of Surgery Case Reports 82 (May 2021): 105915. http://dx.doi.org/10.1016/j.ijscr.2021.105915.

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Sasamori, Hiroki, Kentaro Nakayama, Sultana Razia, et al. "Mutation Profiles of Ovarian Seromucinous Borderline Tumors in Japanese Patients." Current Oncology 29, no. 5 (2022): 3658–67. http://dx.doi.org/10.3390/curroncol29050294.

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Ovarian seromucinous tumors (SMBTs) are relatively rare, and their carcinogenesis is largely unknown. In this study, the molecular features of SMBTs in Japan are assessed. DNA was extracted from microdissected paraffin-embedded sections from 23 SMBT cases. Genetic mutations (KRAS, BRAF, PIK3CA, and ERBB2) were evaluated using Sanger sequencing. Immunohistochemistry for p53, ARID1A, and PTEN was also performed as a surrogate for the loss of functional mutations in these tumor suppressor genes. The prevalence of KRAS, BRAF, PIK3CA, and ERBB2 mutations was 4.3% (1/23), 8.6% (2/23), 8.6% (2/23), and 17.3% (4/23), respectively. Overexpression or loss of p53 expression occurred in 26% (6/23), loss of ARID1A expression in 4.3% (1/23), and none of the cases showed expression of PTEN loss. These findings suggest that KRAS/BRAF/PIK3CA and PTEN mutations are rare carcinogenic events in SMBTs. The high frequency of positive p53 staining and a low frequency of loss of ARID1A staining suggests that SMBT carcinogenesis may be related to the alteration of p53 rather than that of ARID1A. ERBB2 oncogenic mutations may play an important role in the tumorigenesis of Japanese SMBTs.

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Parazzini, F., S. Moroni, E. Negri, C. La Vecchia, R. Mezzopane, and P. G. Crosignani. "Risk factors for seromucinous benign ovarian cysts in northern Italy." Journal of Epidemiology & Community Health 51, no. 4 (1997): 449–52. http://dx.doi.org/10.1136/jech.51.4.449.

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Elwany, Samy, and Sedik Abel Salaam. "Laser Surgery for Allergic Rhinitis: The Effect on Seromucinous Glands." Otolaryngology–Head and Neck Surgery 120, no. 5 (1999): 742–44. http://dx.doi.org/10.1053/hn.1999.v120.a91894.

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40

Buhin, I. Mihoković, D. Vlahović, A. Gudan Kurilj, et al. "Aggressive sinonasal seromucinous carcinoma in a dog - a case report." Journal of Comparative Pathology 203 (May 2023): 81. http://dx.doi.org/10.1016/j.jcpa.2023.03.144.

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Begum, Ferdousi, and TA Chowdhury. "Updates on FIGO Staging Classification and the New WHO Classification for Cancer of the Ovary." Bangladesh Journal of Obstetrics & Gynaecology 32, no. 1 (2017): 33–41. http://dx.doi.org/10.3329/bjog.v32i1.56732.

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Background: The knowledge of different subtypes of ovarian cancer is improving with the progress in molecular pathological research. The WHO classification was revised,in parallel with the implementation of the new FIGO staging classification. The former is mainly based on the histopathological findings and defines the actual type of tumor. It has an important impact on prognosis and therapy of the patient. Materials and methods: FIGO staging classification for cancer of the ovary, fallopian tube, and peritoneum published by Jaime Prat and the new WHO Classification of Ovarian Cancer published by Robert Kurman and coauthors in 2014 are summarized. Results: The International Federation of Gynecology and Obstetrics recently significantly revised staging criteria for cancer of the ovary. The latest revision was based on the concept that high-grade serous tubal intraepithelial carcinoma (STIC) may be the origin of some high-grade serous carcinomas of the ovary and peritoneum. Therefore, staging criteria for the ovary, fallopian tube, and peritoneum have been unified. Understanding this background and other important revised points are essential. The previous focus of mesothelial origin of ovarian cancer has been eliminated in new classification. Instead, a discussion of tubal carcinogenesis of hereditary and some other high-grade serous carcinomas is featured. Regarding serous cancers, the previously assumed pathogenesis pathway may be correct for some, but not for all. The earlier transitional cell type of ovarian cancer has been removed while seromucinous tumors have been added as a new entity. The role of some borderline tumors as one possible step in the progression from benign to invasive lesions is incorporated. The article summarizes the essential updates concerning serous, mucinous, seromucinous, endometrioid, clearcell, and Brenner tumors. Conclusion: The new WHO classification takes into account the recent findings on the origin, pathogenesis, and prognosis of different ovarian cancer subtypes. In both FIGO and WHO classification, the tubal origin of hereditary and some non-hereditary high-grade serous cancers is mentioned in contrast to the hitherto theory of mesothelial origin of tumors. Seromucinous tumors represent a new entity. Bangladesh J Obstet Gynaecol, 2017; Vol. 32(1): 33-41

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HADA, TAIRA, MORIKAZU MIYAMOTO, HIROKI ISHIBASHI, et al. "Ovarian Seromucinous Borderline Tumors Are Histologically Different from Mucinous Borderline Tumors." In Vivo 34, no. 3 (2020): 1341–46. http://dx.doi.org/10.21873/invivo.11911.

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Dwivedi, E., N. Dhameja, M. Lader, and AG Kar. "Ovarian seromucinous tumor: A case series of WHO newly introduced entity." Tropical Journal of Obstetrics and Gynaecology 36, no. 3 (2019): 408. http://dx.doi.org/10.4103/tjog.tjog_30_19.

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Nakamura, Hiromu, and Syu Yamanobe. "A Case of Seromucinous Hamartoma in the Left Posterior Nasal Cavity." Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology) 58, no. 4 (2019): 706–11. http://dx.doi.org/10.7248/jjrhi.58.706.

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Katzka, D. A. "Proton Pump (H+/K+-ATPase) Expression in Human Laryngeal Seromucinous Glands." Yearbook of Gastroenterology 2006 (January 2006): 5–6. http://dx.doi.org/10.1016/s0739-5930(08)70239-3.

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Kim, K. A. "Seromucinous tumors of ovary: Computed tomographic and magnetic resonance imaging features." Gynecologic Oncology 159 (October 2020): 343. http://dx.doi.org/10.1016/j.ygyno.2020.05.635.

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47

Massicot, Richard, Véronique Rousseau, Ahmed A. Darwish, Frédérique Sauvat, Francis Jaubert, and Claire Nihoul-Fékété. "Serous and seromucinous infantile ovarian cystadenomas—A study of 42 cases." European Journal of Obstetrics & Gynecology and Reproductive Biology 142, no. 1 (2009): 64–67. http://dx.doi.org/10.1016/j.ejogrb.2008.09.007.

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Tomasz, Ścięgosz, Kwiatek Renata, El-Hassanieh Izabela, and Ziółkowski Piotr. "Oncocytic papillary cystadenoma of right laryngeal ventricle." Archives of Case Reports 5, no. 1 (2021): 012–13. http://dx.doi.org/10.29328/journal.acr.1001048.

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A case of oncocytic papillary cystadenoma in a 72-year old woman, a rare tumor of laryngeal seromucinous glands of unclear nature is presented. The patient had a history of chronic inflammation of laryngeal mucosa and both her age and tumor location were typical. The lesion was resected transorally without complications. Histological findings are shown in the present study. The controversial status of oncocytic papillary cystadenoma as either a true neoplasm or a combination of metaplastic and hyperplastic changes, its resemblance to Warthin’s tumor and optimal approach to treatment are discussed.

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Altman, Kenneth W., Yayoi Kinoshita, Melin Tan, David Burstein, and James A. Radosevich. "Western Blot Confirmation of the H+/K+-ATPase Proton Pump in the Human Larynx and Submandibular Gland." Otolaryngology–Head and Neck Surgery 145, no. 5 (2011): 783–88. http://dx.doi.org/10.1177/0194599811415589.

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Objective. The authors have previously demonstrated the H+/K+-ATPase (proton pump) in human larynx and lung glands via immunohistochemistry (IHC). The present hypothesis is that the proton pump is expressed in other seromucinous glands of the digestive tract that can be confirmed by IHC and Western blot analysis. Study Design. Prospective controlled tissue analysis study. Setting. Academic medical institution. Methods. Ten anonymous fresh-frozen donor specimens were obtained, comprising 3 submandibular glands, 4 larynges, and 3 normal stomach specimens for control. Submandibular gland sections were immunostained with 2 monoclonal antibodies selectively reactive with α or β subunits of the H+/K+-ATPase. Western blot analysis was performed on all specimens. Results. Consistent IHC staining was observed in the submandibular gland specimens for both α and β subunits. Western blot analysis revealed very strong expression for the stomach at 100 kDa, corresponding to the α protein, and weak but notable banding for all larynx and submandibular gland specimens. Similar findings were noted for the 60- to 80-kDa glycosylated β subunit protein, as well as the 52-kDa β subunit precursor for all specimens. Conclusion. The H+/K+-ATPase (proton) pump is present in the human larynx and submandibular gland although in much lower concentrations than in the stomach. Proton pump involvement in human aerodigestive seromucinous glands may have a role in protecting mucosa from acid environments (local or systemic), explain heightened laryngeal sensitivity in those patients with laryngopharyngeal reflux, and be a site of action for proton pump inhibitor pharmacotherapy.

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Elwany, Samy, and M. Hesham Abdel-Moneim. "Carbon dioxide laser turbinectomy. An electron microscopic study." Journal of Laryngology & Otology 111, no. 10 (1997): 931–34. http://dx.doi.org/10.1017/s0022215100139003.

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AbstractTen patients with chronic non-allergic rhinitis and presenting mainly with nasal obstruction due to hypertrophied inferior turbinates were subjected to laser turbinectomy using CO2. Tiny biopsies were taken, at the time of surgery as well as one monthlater, and were processed for transmission electron microscopy. The ultrastructural observations included: early epithelial loss which wasfollowed by prompt regeneration of healthy epithelium, decreased number and activity of the seromucinous glands, fibrosis of the connective tissue stroma, as well as diminished number and congestion of the cavernous blood spaces. These observations were discussed in view of the excellent clinical response of the patients.

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