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Dissertations / Theses on the topic 'SERPINH1'

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Published: 7 July 2024
Last updated: 31 July 2025

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1

Furtado, Clara Fernanda Barbirato. "Investigação de mutações nos genes LEPRE1, CRTAP, PPIB, FKBP10, SERPINH1 e SERPINF1 causadoras da osteogênese imperfeita recessiva." Universidade Federal do Espírito Santo, 2015. http://repositorio.ufes.br/handle/10/4522.

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Made available in DSpace on 2016-08-29T15:34:42Z (GMT). No. of bitstreams: 1 tese_8279_Tese_Clara Fernanda Barbirato.pdf: 794712 bytes, checksum: 13290894bcf3053215336989ea116592 (MD5) Previous issue date: 2015-02-13<br>A Osteogênese Imperfeita (OI) é uma doença clínica e geneticamente heterogênea caracterizada, predominantemente, por fragilidade e deformidade ósseas e por fraturas recorrentes. A maioria dos casos de OI resulta de mutações autossômicas dominantes nos genes COL1A1 e COL1A2, que codificam as cadeias formadoras do colágeno tipo I, principal proteína dos ossos. Nos últimos
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2

Wegehaupt, Oliver Philipp [Verfasser], and Michael [Akademischer Betreuer] Köttgen. "BAG2, BAT3, DNAJB11, GNB2L1 und SERPINH1 interagieren in einem Netzwerk mit dem Polycystin-1-TRPP2-Signalmodul." Freiburg : Universität, 2016. http://d-nb.info/1122647816/34.

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3

Pierce, Charles. "The role of the gene SERPINH1 as a pharmacogenetic biomarker for choroidal neovascularization (CNV) responses to anti vascular endothelial growth factor (VEGF) treatment in clinical practice." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/417281/.

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Age related macular degeneration is the commonest cause of blindness in the western world and current treatment regimens represent a significant output for national health services. The disease process is multifactorial in origin and has a variable progression and response to current methods of treatment. A targeted approach with individualized therapy based on recognized biomarkers to predict disease outcome would be the ideal treatment modality. We plan to investigate the role of genes known to influence the progression of early AMD to the advanced stage (wet AMD) with emphasis on genes invo
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4

Prévot, Pierre-Paul. "Rôles de la protéine Iris dans l'accomplissement du repas sanguin de la tique Ixodes ricinus." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210730.

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Les tiques sont des arthropodes ectoparasites obligatoires qui se nourrissent sur une grande variété de vertébrés sur une large partie du globe. Au cours de leur repas, les tiques sécrètent dans leur salive de nombreux facteurs leur permettant de contourner bon nombre des défenses de l’hôte. Bien que la littérature rapporte beaucoup d’informations au sujet des effets du repas de la tique sur l’hôte, la nature des facteurs actifs exprimés par les glandes salivaires de la tique est peu connue. Au cours d’anciens travaux au sein du laboratoire, le crible de deux banques d’ADN complémentaires - is
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5

Ulbricht, David, Jan Pippel, Stephan Schultz, René Meier, Norbert Sträter та John T. Heiker. "A unique serpin P1′ glutamate and a conserved β-sheet C arginine are key residues for activity, protease recognition and stability of serpinA12 (vaspin)". Portland Press, 2015. https://ul.qucosa.de/id/qucosa%3A33439.

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SerpinA12 (vaspin) is thought to be mainly expressed in adipose tissue and has multiple beneficial effects on metabolic, inflammatory and atherogenic processes related to obesity. KLK7 (kallikrein 7) is the only known protease target of vaspin to date and is inhibited with a moderate inhibition rate. In the crystal structure, the cleavage site (P1-P1′) of the vaspin reactive centre loop is fairly rigid compared with the flexible residues before P2, possibly supported by an ionic interaction of P1′ glutamate (Glu379) with an arginine residue (Arg302) of the β-sheet C. A P1′ glutamate seems high
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6

Mkaouar, Héla. "Rôle des serpines, inhibiteurs de protéases à serine, du microbiote digestif humain dans les maladies inflammatoires de l'intestin." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS108.

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Les inhibiteurs des protéases à sérine (Serpins) constituent une classe d'enzymes très peu étudiée chez les bactéries. Dans ce travail de thèse nous nous sommes intéressés à l'étude des serpins provenant du microbiote intestinal et l'investigation de leur potentiel anti-inflammatoire pour le traitement des maladies inflammatoires chroniques de l'intestin (MICI) chez l'homme. Pour cela nous avons identifié les serpins provenant du microbiote intestinal humain et analysé leur diversité ainsi que leur distribution entre les individus malades et sains. Ces données nous ont permis d'isoler les serp
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7

Götzfried, Jessica Tanja Tamara [Verfasser], and Karl-Peter [Akademischer Betreuer] Hopfner. "Genetic, biochemical and preclinical studies on a tandem cluster of two human serpins: alpha-1-antitrypsin and serpina2 / Jessica Tanja Tamara Götzfried ; Betreuer: Karl-Peter Hopfner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1160876223/34.

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8

Souza, Lucas Rodrigo de. "Desenvolvimento de bibliotecas baseadas em serpinas para geração de inibidores de calicreínas teciduais humanas." reponame:Repositório Institucional da UFABC, 2017.

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Orientador: Prof. Dr. Luciano Puzer<br>Tese (doutorado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biossistemas, 2017.<br>As calicreinas teciduais humanas (KLKs) compreendem uma familia de quinze serino proteases encontradas em uma diversidade de fluidos e tecidos biologicos. Estas enzimas sao identificadas como possuindo papel em diferentes doencas como Alzheimer, cancer, dermatite atopica, esclerose multipla, Parkinson, psoriase e outras. Existe, portanto, uma crescente demanda por inibidores especificos para cada uma das calicreinas e este e o objetivo do nosso grupo de pes
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9

Evans, Dyfed Ll. "The heparin activateable serpins." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385390.

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10

Aymonnier, Karen. "La protease Nexine-1, une cible prometteuse dans le traitement de l'hémophilie et son rôle dans les polynucléaires neutrophiles." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCC049.

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L’hémophilie A est une maladie hémorragique rare caractérisée par un déficit du facteur de la coagulation VIII (FVIII). De nouvelles stratégies thérapeutiques ne reposant pas sur l’injection de FVIII se développent. Nous proposons une approche innovante qui consiste à cibler un anticoagulant naturel présent dans les plaquettes, la Protéase Nexine-1 (PN-1). La PN-1 est un inhibiteur puissant de la thrombine, enzyme clé de la coagulation. Bloquer la PN-1 favoriserait ainsi la génération de thrombine et donc la coagulation chez les patients hémophiles. Nous avons montré que bloquer la PN-1 amélio
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11

Pippel, Jan, E. Bartholomeus Kuettner, David Ulbricht, et al. "Crystal structure of cleaved vaspin (serpinA12)." De Gruyter, 2016. https://ul.qucosa.de/id/qucosa%3A33438.

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The adipokine vaspin (serpinA12) is mainly expressed in white adipose tissue and exhibits various beneficial effects on obesity-related processes. Kallikrein 7 is the only known target protease of vaspin and is inhibited by the classical serpin inhibitory mechanism involving a cleavage of the reactive center loop between P1 (M378) and P1′ (E379). Here, we present the X-ray structure of vaspin, cleaved between M378 and E379. We provide a comprehensive analysis of differences between the uncleaved and cleaved forms in the shutter, breach, and hinge regions with relation to common molecular featu
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12

Crowther, Damian C. "The bioengineering of targeted serpins." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260598.

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13

Pemberton, Philip A. "The serpins : structure: function relationships." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315252.

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14

Afridi, Junaid. "Small Molecules Binding to Serpins." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1301.

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Serpins are a unique breed of proteins due to their enzymatic mechanism. Two systems were closely monitored during fluorescent binding studies, the ACT-CHY along with the AT:TRY interaction. Four different conformational variants of each system were studied including the native, cleaved, latent and complex forms. Three different fluorescent dyes were used to identify the conformations including ANS, TNS, and bis-ANS. SI studies and protease assays utilizing both Suc-AAPF-pNA and L-BAPNA were instrumental in determining conformations along with gel electrophoresis studies. The hydrophobic dyes
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15

Hopkins, Paul Charles Richard. "The serpin hinge region." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306982.

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16

Andrade, Regina Aparecida de. "Desenvolvimento de Vioserpina para estudo de especificidade e inibição da calicreína tecidual humana 5 recombinante, utilizando mutantes da vioserpina." reponame:Repositório Institucional da UFABC, 2017.

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Orientador: Prof. Dr. Luciano Puzer<br>Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biossistemas, São Bernardo do Campo, 2017.<br>Serpina é o nome dado à superfamília de proteínas com uma vasta diversidade de funções biológicas, que tem como principal característica a inibição irreversível de serino proteases. A característica estrutural mais marcante das serpinas é a presença de uma alça na sua porção C-terminal, composta por 20 aminoácidos denominados alça do centro reativo (RCL). A RCL é a região da serpina que se liga covalentemente ao sítio ativo da s
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17

Monnien, Franck. "Biomarqueurs histopronostiques de l'adénocarcinome canalaire du pancréas : évaluation d’un panel immunohistochimique intégrant les trois compartiments tumoraux épithéliaux, fibroblastiques et immunitaires." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2023. http://www.theses.fr/2023UBFCE021.

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La recherche d’abords thérapeutiques innovants est particulièrement d’actualité dans l’adénocarcinome canalaire du pancréas (ACP) tant le pronostic de ce cancer, dont l’incidence augmente, reste redoutable. Une des voies d’exploration réside dans la compréhension des mécanismes entrainant l’importante réaction stromale habituellement constatée dans l’ACP et prédisant la résistance à la chimiothérapie. Cette réorganisation tissulaire ou desmoplasie, résulte de l’activation de cellules normales présentes dans le tissu conjonctif de l’organe touché par les cellules tumorales d’origine épithéliale
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18

Hermans, Josephine Margaret. "The nature of serpine-enzyme complexes." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309323.

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19

Rau, Jill Camille Church Frank C. "Engineering of serpins for vascular application." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1558.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pathology and Laboratory Medicine." Discipline: Pathology and Laboratory Medicine; Department/School: Medicine.
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20

Silva, Aline Correa da. "Polimorfismo do gene SPi2 na obstrução recorrente das vias aéreas e na doença inflamatória das vias aéreas em cavalos puro sangue de corrida." Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/10026.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Recurrent airway obstruction (RAO) and inflammatory airway disease (IAD) show high prevalence and are economically important in equine athletes. RAO is considered a multifactorial disease due to genetic and environmental components in their patophysiology. The aim of this study was to determine the presence of polymorphism at exons 2, 3, 4 and 5 of the SPi2 gene and a possible association between them and ORA or IAD on 51 thoroughbred horses through single-strand conformational polymorphism (SSCP). Exons 2, 3 and 4 of the Spi2 gene
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21

Oliveira, Jocélia Pereira de Carvalho. "Estudo de inibidores de serino proteases : serpinas bacterianas e compostos peptideomiméticos derivados do isomanídeo." reponame:Repositório Institucional da UFABC, 2014.

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Orientador: Prof. Dr. Luciano Puzer<br>Tese (doutorado) - Universidade Federal do ABC, Programa de Pós-Graduação em Ciência & Tecnologia - Química, 2014.<br>Serpina é o nome dado a uma superfamília de proteínas com grande diversidade de funções biológicas, e que tem como principal característica a inibição de serino proteases. Até meados do ano de 2002, acreditava-se que as serpinas eram exclusivas de organismos eucarióticos. No entanto, com o desenvolvimento das técnicas de sequenciamento de genomas, essas proteínas passaram a ser identificadas também em organismos procariotos. Assim com o ob
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22

Emmerich, Joseph. "Pathologie moleculaire des serpines et anomalies de l'hemostase." Paris 7, 1995. http://www.theses.fr/1995PA077191.

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L'antithrombine (at) et l'alpha-1-antitrypsine (1 at) appartiennent a la super famille des serpines. Nous decrivons les bases moleculaires de plusieurs deficits en at de type i et ii. La structure primaire du gene expliquerait certaines mutations par derapage replicatif, rendant compte de certaines deletions et mutations recurrentes. Une mutation phe 402 leu de l'at a ete analysee ; le variant a une stabilite accrue au sodium dodecyl sulfate, suggerant que la boucle du site actif pourrait etre inseree dans le feuillet ba. Trois autres mutations sont responsables de la formation de complexes de
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Baek, Kyuwon. "Serpin expression and structural studies." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615861.

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Padrón-Barthe, Laura. "LEI/L-DNase II : mécanisme d'activation et régulation de la mort cellulaire." Paris 5, 2006. http://www.theses.fr/2006PA05D044.

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La mort cellulaire est un processus indispensable à l'homéostasie des organismes. Les premières protéases impliquées dans l'apoptose furent les caspases. Cependant, leur participation n'est plus considérée comme une étape obligatoire, plusieurs effecteurs indépendants de l'activation des caspases ayant été mis en évidence. Un de ces effecteurs, caractérisé dans notre laboratoire, est la LEI/L-DNase II. Cette protéine appartient à la famille des serpines. Nous avons montré que la LEI (antiprotéase) change de conformation en découvrant un site endonucléase, la transformant ainsi en L-DNase II (e
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Chang, Wun-Shaing Wayne. "Conformational mobility and interactions of the serpins." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387511.

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26

Stein, Penelope E. "Structure and function of non-inhibitory serpins." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358806.

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Polderdijk, Stéphanie Gabriëlle Irene. "Engineering serpins for the treatment of haemophilia." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709430.

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28

Turato, Cristian. "Implicazioni biologiche di SerpinB3 nella fibrosi epatica e nell'epatocarcinoma." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421977.

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BACKGROUND SERPINB3 is a serine protease inhibitor belonging to the serpin family, characterized by pleyotropic functions. TGF-beta1 is the master cytokine in the pathogenesis of liver fibrosis. Inflammatory and mesenchymal cells, including hepatic stellate cells, have been identified as the principal source of this cytokine, however growing evidence also supports the ability of parenchymal hepatocytes to produce TGF-beta1. Recently, a direct correlation between TGF-beta1 and the ov-serpin SERPINB3 has been reported in idiopatic pulmonary fibrosis, whose pathological features recall cirrhosis
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Minillo, Renata Moldenhauer [UNIFESP]. "Caracterização clínica, radiológica e molecular de osteogênese imperfeita autossômica recessiva em família brasileira com consanguinidade parental." Universidade Federal de São Paulo (UNIFESP), 2013. http://repositorio.unifesp.br/handle/11600/22833.

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Made available in DSpace on 2015-12-06T23:46:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2013<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Objetivo: Descrever clinica e radiologicamente os individuos afetados pela Osteogenese Imperfeita (OI) (OMIM 613982) em uma familia endocruzada procedente de Bueno Brandao, MG; definir a mutacao genetica responsavel pela doenca e identificar variabilidade fenotipica intrafamiliar. Metodologia: Levantamento genealogico com visitas domiciliares de familia demonstrando consanguinidade em 8 geracoes, com tres individuos
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Dufour, Erick. "Caractérisation des propriétés biochimiques de serpines modifiées ciblant la furine." Thèse, Université de Sherbrooke, 2004. http://savoirs.usherbrooke.ca/handle/11143/4186.

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L'[alpha][indice inférieur 1]-antitrypsine ([alpha][indice inférieur 1]-AT), un inhibiteur naturel de l'élastase, et l'[alpha][indice inférieur 1]-antichymotrypsine ([alpha][indice inférieur 1]-ACT) appartiennent à la superfamille des serpines, qui sont des inhibiteurs irréversibles de sérines protéinases. Nous avons développé une approche qui consiste à modifier la boucle du site réactif de ces serpines afin de cibler diverses sérines protéinases impliquées dans le clivage de précurseurs protéiques (furine) ou de protéines de la matrice extracellulaires (élastase). La furine est une sérine pr
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Dufour, Erick. "Caractérisation des propriétés biochimiques de serpines modifiées ciblant la furine." Sherbrooke : Université de Sherbrooke, 2004.

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32

Villano, Gianmarco. "Caratterizzazione di un modello di topo transgenico per SERPINB3 umana." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3427212.

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the serpins are a family of serine protease inhibitors involved in several biological functions and in the maintenance of cell homeostasis. SERPINB3 (known as SCCA1), a member of the ovalbumin family, is normally expressed in squamous epithelium, and it is over-expressed in tumours of epithelial origin and in hepatocellular carcinoma. The SERPINB3 involvement in the control of proteolytic processes has important implications in neoplastic transformation, whereas the balance between proteases and their inhibitors can affect cell motility, invasiveness, proliferation and apoptosis. Consideri
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33

Zhang, Bin. "The role and mechanism of a serpin angiogenic inhibitor in diabetic retinopathy." Oklahoma City : [s.n.], 2010.

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34

Posarac, Vesna. "Characterization and anti-HIV activity of the proprotein convertase-directed serine protease inhibitor, Spn4A." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/3434.

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HIV/AIDS is a global health problem of immense magnitude, with 33 million people living with HIV and 2 million AIDS-related deaths per year. As the development of drug resistance undermines treatment efficacy, the long-term success of anti-retroviral therapy depends upon the introduction of novel drugs aimed at additional targets essential for the viral life cycle. With a critical role in many viral diseases including the proteolytic maturation of the HIV-1 envelope glycoprotein gp160, the secretory pathway proprotein convertases (PCs) represent a potential anti-viral target. Our laboratory ha
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Rahman, Syeda Sharmin. "Measurement and characterization of HIV inhibitory Clade A Serpins in the cervical mucosa of highly HIV-1 exposed seronegative individuals." American Chemical Society (ACS) Publications, 2011. http://hdl.handle.net/1993/5065.

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Objective: Serpins are serine protease inhibitors that are involved in a wide variety of biological functions in nature. They are known to regulate inflammation processes as well as provide host defense against microorganisms. Recent evidence has associated many types of mucosal serpins with a protective phenotype against HIV infection in women. Our hypothesis is that serpins with known antiviral activity against HIV-1 are correlated with protection in a group of HIV exposed seronegative individuals (HIV-resistant) from the Pumwani sex worker cohort. Study design: Cervico-vaginal lavage (CV
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Sendall, Timothy James. "Investigating the molecular mechanism of serpin polymerisation." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610868.

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37

Horvath, Anita Julieanne. "Molecular characterisation of the murine α₁-antichymotrypsin-like serpins". Monash University, Dept. of Medicine, 2004. http://arrow.monash.edu.au/hdl/1959.1/9713.

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Devlin, Glyn L. "The mechanisms of serpin misfolding and its inhibition." Monash University, Dept. of Biochemistry and Molecular Biology, 2003. http://arrow.monash.edu.au/hdl/1959.1/9469.

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39

Brum, Lauren Morges. "Characterization of the poxvirus serpins SPI-1 and SPI-3." [Gainesville, Fla.]: University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0000653.

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40

Gulley, Melissa M. "Biochemical characterization of serpins in the malaria vector, Anopheles gambiae." Thesis, Kansas State University, 2013. http://hdl.handle.net/2097/15870.

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Master of Science<br>Division of Biology<br>Kristin Michel<br>To date malaria is the most important tropical disease, which is caused by Plasmodium sp. and vectored by anopheline mosquitoes. The mosquito’s immune system is one of the limiting factors of malaria transmission. Immune reactions, such as the prophenoloxidase (PPO) pathway result in the melanization of pathogens, and are effective at limiting parasite numbers. Novel strategies for malaria control aim to exploit the immune system to interrupt parasite transmission by boosting the immune responses in the mosquito vector. Serpins pla
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Tirloni, Lucas. "Identificação e caracterização de inibidores de serino-endopeptidases (serpinas) em Rhipicephalus (Boophilus) microplus." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/60512.

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Carrapatos são animais hematófagos transmissores de diversas doenças para animais e seres humanos. O Rhipicephalus (Boophilus) microplus é um ectoparasito específico de bovinos. É responsável por importantes perdas econômicas na pecuária de países produtores de carne e leite. O aumento de populações de carrapatos resistentes aos principais acaricidas usados e a possível contaminação ambiental e dos produtos derivados como carne e leite impõem estudos para desenvolver novos métodos de controle. O controle imunológico é uma estratégia comprovadamente viável, porém ainda falta encontrar antígenos
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42

Wong, Ching-mang Queenie. "Structural determination of antimicrobial peptides derived from human lactoferricin and ovalbumin." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36934732.

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Wong, Ching-mang Queenie, and 王靜萌. "Structural determination of antimicrobial peptides derived from human lactoferricin and ovalbumin." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36934732.

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44

Guérin, Jean-Luc. "Analyse biologique et fonctionnelle de serp3 et mv-lap,deux facteurs de pathogenicite du virus myxomateux (doctorat microbiologie)." Paris 11, 2001. http://www.theses.fr/2001PA114809.

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45

TRANCOZO, M. "CARACTERIZAÇÃO DO PADRÃO DE MUTAÇÕES DOS GENES LEPRE1, CRTAP, PPIB, FKBP10, WNT1, SP7, SERPINF1 EM OSTEOGÊNESE IMPERFEITA." Universidade Federal do Espírito Santo, 2016. http://repositorio.ufes.br/handle/10/7096.

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Made available in DSpace on 2018-08-01T20:28:08Z (GMT). No. of bitstreams: 1 tese_9932_Dissertação_Maira Trancozo.pdf: 750603 bytes, checksum: b325e8b4e134bd6ec4eb5bc70315d8c5 (MD5) Previous issue date: 2016-03-02<br>A Osteogênese Imperfeita (OI) ou doença dos ossos frágeis é uma desordem hereditária dos tecidos conjuntivos que contém colágeno em sua formação. Mais de 15 genes relacionados com herança recessiva têm sido relatados dos últimos anos. A maioria destes genes codificam proteínas responsáveis por modificações pós traducionais do colágeno I. Com o objetivo de caracterizar o padrão d
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GOMEZ, C. M. F. "ANÁLISE DO POTENCIAL DA OSTEOPONTINA E DA SERPINA1 COMO BIOMARCADORES DO CARCINOMA EPIDERMÓIDE DE CABEÇA E PESCOÇO." Universidade Federal do Espírito Santo, 2017. http://repositorio.ufes.br/handle/10/7108.

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Made available in DSpace on 2018-08-01T21:35:02Z (GMT). No. of bitstreams: 1 tese_10966_CelenyFiguera_Dissertação_PPGBiotec (Final).pdf: 1556599 bytes, checksum: 51c85b164333a4f542d5ac9fbca3c088 (MD5) Previous issue date: 2017-02-22<br>O carcinoma epidermóide de cabeça e pescoço (CECP) representa o tipo histológico mais frequente nos cânceres de cabeça e pescoço. Apesar dos numerosos estudos realizados ainda não foi estabelecido um conjunto comum de biomarcadores para o CECP que facilitem o prognóstico e o diagnóstico precoce. O objetivo deste estudo foi avaliar no CECP o possível potenc
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Kutzner, Tanja Jasmin [Verfasser]. "Isolierung, Charakterisierung und phylogenetischer Vergleich von Serpinen basaler Vertebraten / Tanja Jasmin Kutzner." Bielefeld : Universitätsbibliothek Bielefeld, 2013. http://d-nb.info/1048175987/34.

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Pelte, Nadège. "Serpines et protéases à sérine dans la réponse immunitaire de la drosophile." Université Louis Pasteur (Strasbourg) (1971-2008), 2004. http://www.theses.fr/2004STR13086.

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Les Arthropodes se défendent contre les agressions microbiennes par un ensemble de réactions très efficaces, comprenant l'activation de cascades protéolytiques aboutissant à la coagulation, à la mélanisation et à la synthèse de peptides antimicrobiens. Ces cascades protéolytiques font intervenir des protéases à sérine et sont régulées par des serpines, qui sont des inhibiteurs de protéases à sérine. L'équipe au sein de laquelle j'ai effectué ma thèse étudie le rôle de serpines et de protéases à sérine dans la réponse immunitaire de la drosophile. La première cascade protéolytique mise en évide
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Zani, Marcelo Bergamin. "Incorporação de um aminoácido fluorescente em serpinas para inibição de serino-proteases." reponame:Repositório Institucional da UFABC, 2018.

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Orientador: Prof. Dr. Luciano Puzer<br>Tese (doutorado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biossistemas, 2018.<br>Serpinas sao proteinas inibidoras de serino-proteases, responsaveis pelo controle dos mais diversos processos fisiologicos e que cujo mecanismo de inibicao consite em formar um complexo covalente com a enzima alvo, em um processo de inibicao irreversivel. A alca de centro reativo (RCL) e responsavel por interagir com a protease, mimetizando um substrato, e quando clivada se insere como uma ¿À-fita no interior da serpina, trazendo a protease e causando uma d
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Benchabane, Meriem. "Modifications post-traductionnelles d'une serpine humaine recombinante exprimée chez les plantes." Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24868/24868.pdf.

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