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1

Nair, Sreelakshmi R., and Subathra Devi C. "Serratiopeptidase: An integrated View of Multifaceted Therapeutic Enzyme." Biomolecules 12, no. 10 (2022): 1468. http://dx.doi.org/10.3390/biom12101468.

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Microbial products have been used for the treatment of different diseases for many centuries. The serratiopeptidase enzyme provides a new hope for COVID-19-infected patients. Nowadays, anti-inflammatory drugs are easy to obtain at minimal expenditure from microbial sources. Serratia sp. is identified as one of the most efficient bacteria produced from serratiopeptidase. Screening for new and efficient bacterial strains from different sources has been of interest in recent years. Serratiopeptidase remains the most well-known anti-inflammatory drug of choice. Serratiopeptidase is a cheaper and s
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M. Mikhael, Ehab, and Mahdi Y. Mohammed. "Serratiopeptidase a Hope in a Rapid and Better Improvement of Inflammatory Acne Vulgaris." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 21, no. 1 (2017): 78–81. http://dx.doi.org/10.31351/vol21iss1pp78-81.

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Acne vulgaris is a very common, chronic disorder, involving inflammation of the pilosebaceous units that can be varied in presentation and difficult to treat. Inflammatory acne may yield both scarring and pigmentary changes so early and adequate therapy will, in all cases, decrease its severity and may entirely suppress this disease. Serratiopeptidase has anti-inflammatory, anti-edemic and fibrinolytic activity and acts rapidly on localized inflammation. Serratiopeptidase was added in aim to hasten acne resolution. During March to July 2010, A comparative study for a 50 healthy patient sufferi
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Kumar Mp, Santhosh. "THE EMERGING ROLE OF SERRATIOPEPTIDASE IN ORAL SURGERY: LITERATURE UPDATE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 19. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.23471.

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Serratiopeptidase, a proteolytic enzyme derived from Serratia E-15 species enterobacteria, is widely used in medical field for its anti-inflammatory, anti-edemic properties, and analgesic properties. It is being used commonly in various specialties such as orthopedics, otolaryngology, gynecology, surgery, pulmonology, ophthalmology, and dentistry. Research has shown that serratiopeptidase is the most effective anti-inflammatory agent compared to other enzyme preparations. This article reviews the efficacy, safety, and applications of serratiopeptidase in oral surgery. This article also discuss
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Gurzhenko, Y. M., O. V. Shulyak, V. V. Spirydonenko, and O. Yu Gurzhenko. "SYSTEMIC ENZYME THERAPY DRUGS IN THE TREATMENT OF PATIENTS WITH CHRONIC INFLAMMATORY DISEASES OF THE MALE GENITAL ORGANS." Ukrainian Journal of Urology, no. 2(6) (June 20, 2025): 53–69. https://doi.org/10.71217/uju.2(6).2025.53-69.

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ABSTRACTS. Chronic inflammatory diseases of the male genital organs are one of the most relevant pathological processes in the male reproductive system, it is characterized by high prevalence and different views of modern medical science on its pathogenesis and treatment. The prevalence of CP in the world is increasing every year, it has great medical and social significance. Therefore, effective therapy of the above pathology, which involves the use of modern treatment methods, is one of the most important tasks of urology. The purpose of the work is to study the theoretical references of the
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Meng, Yaru, Miaomiao Yang, Wan-Qiu Liu, and Jian Li. "Cell-Free Expression of a Therapeutic Protein Serratiopeptidase." Molecules 28, no. 7 (2023): 3132. http://dx.doi.org/10.3390/molecules28073132.

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Serratiopeptidase is a clinical therapeutic protein for the treatment of human diseases such as arthritis, bronchitis, and thrombosis. Yet production of this protein in a heterologous host (e.g., Escherichia coli) is difficult due to the issue of protein insolubility and the requirement of laborious refolding procedures. Cell-free protein synthesis (CFPS) systems, derived from crude cell extracts, are effective platforms for the expression of recombinant proteins in vitro. Here, we report a new method to produce serratiopeptidase by using an E. coli-based CFPS system. After rational selection
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K.C, Suma, Manasa H, Likhitha A, and Nagamani T.S. "Isolation, Purification, and Characterization of Serratiopeptidase Enzyme from Serratia marcescens." International Journal of Innovative Science and Research Technology 5, no. 7 (2020): 156–61. http://dx.doi.org/10.38124/ijisrt20jul135.

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Serratiopeptidase is a proteolytic enzyme that is derived from a member of Enterobacteriaceae. Serratia marcescens is a gram-negative bacteria identified characteristically, which produces a red pigment called prodigiosin. Serratiopeptidase is a multifunctional proteolytic enzyme that dissolves non-living tissues such as fibrin, blood clots, inflammation in all forms without harming living tissues. In this study, the organism was isolated from the diseased silkworm's pupa by using Luria- Bertani (LB) agar media. The enzyme production can be enhanced by applying different physical and chemical
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Arbildo-Vega, Heber, Alfredo Rendón-Alvarado, Taniax Castillo-Cornock, Fredy Cruzado-Oliva, Alex Vidal-Mosquera, and Hernán Vásquez-Rodrigo. "Efficacy of serratiopeptidase in third molar surgery. A systematic review and meta-analysis." Journal of Oral Research 12, no. 1 (2023): 348–61. http://dx.doi.org/10.17126/joralres.2023.030.

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Objective: To determine the efficacy of serratiopeptidase in third molar surgery. Materials and Methods: A bibliographic search was carried out until April 2022, in the biomedical databases: Pubmed/Medline, Cochrane Central Registry of Clinical Trials, Scopus, Scielo and Google Scholar. Studies reporting the ef-ficacy of serratiopeptidase in third molar surgery, which were randomized clinical trials, in English and without time limits, were included. The RoB 2.0 tool was used to assess the risk of the included studies and the GRADEPro GDT tool to assess Results: The preliminary search yielded
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8

Gowtham, Dr S. E. "A Comparative Study of Diclofenac with Paracetamol versus Diclofenac with Serratiopeptidase in Pain Associated with Soft Tissue Injury." International Journal for Research in Applied Science and Engineering Technology 9, no. 8 (2021): 2740–44. http://dx.doi.org/10.22214/ijraset.2021.37848.

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Abstract: The point of the executives is to ease the pain rapidly and improve practical capacity. NSAIDs are the primary line treatment. Serratiopeptidase is the proteolytic enzyme. The challenge lies in deciding whether only NSAIDs or NSAIDs with proteolytic enzyme will give more prominent indicative help, while additionally being savvy. the primary goal is to think about the adequacy of diclofenac with paracetamol and diclofenac with serratiopeptidase in the administration of delicate tisssue injury. This prospective, open label, observational study was conducted at a tertiary care hospital.
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Chitra Khanwelkar, Kartik Peethambaran, and Sujata Jadhav. "The Comparison of Anti-inflammatory and Analgesic Effect of Diclofenac Alone with Combined Treatment with Diclofenac and Serratiopeptidase in Patients having Osteoarthritis of Knee Joint." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 7160–65. http://dx.doi.org/10.26452/ijrps.v11i4.3840.

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Oral proteolytic enzymes like serratiopeptidase are very commonly used by clinicians either alone or in combination with non-steroidal anti-inflammatory drugs for analgesia and anti-inflammatory purpose. As the activity of these drugs is not proved in trials, and they are not listed in any country's official pharmacopoeia, it was planned to study their effect in osteoarthritis patients. Two groups (n= 30 each) of diagnosed knee osteoarthritis patients, were treated with diclofenac 50 mg twice a day (BID) and serratiopeptidase 10mg three times a day (TID) + Diclofenac 50 mg BID for two weeks. T
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Shukla, Amitabh D., and Vaidehi Agarwal. "Does Serratiopeptidase prevent thoracic surgery in patients of hydropneumothorax of tubercular aetiology?" Lung India 40, no. 5 (2023): 445–48. http://dx.doi.org/10.4103/lungindia.lungindia_109_23.

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ABSTRACT Background: Tubercular hydropneumothorax is commonly seen in Indian hospitals. Anti-tuberculosis drugs and intercostal drainage tube (ICD) insertion are the mainstays of treatment. But many patients have to be referred to thoracic surgery for surgical management. This study aims to evaluate the role of serratiopeptidase in successful resolution of tubercular hydropneumothorax and avoidance of thoracic surgery. Methods: We conducted a retrospective observational cohort study on 28 patients that were admitted to extrapulmonary TB ward of our hospital. All patients were given anti-TB dru
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11

Ramasubbu, Subhashini, and Abdul Wahab P. U. "Comparison of Efficacy of Oral Bromelain and Serratiopeptidase for the Control of Postoperative Sequelae Following Third Molar Surgery - A Comparative Study." Journal of Evolution of Medical and Dental Sciences 10, no. 31 (2021): 2476–80. http://dx.doi.org/10.14260/jemds/2021/506.

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BACKGROUND Surgical removal of impacted third molar is widely carried out in general dental practice and is usually associated with postoperative inflammatory sequelae like pain, swelling, and trismus. The objective of the study was to assess and compare the efficacy of oral bromelain and Serratiopeptidase for the control of post-operative sequelae following surgical removal of impacted third molar. METHODS A randomized, comparative clinical study was conducted on sixty patients who were undergoing impacted third molar surgery, and were allocated into two groups each comprising 30 patients. Co
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Melchor-Moncada, Jhon Jairo, Alejandra García-Barco, Augusto Zuluaga-Vélez, Luz Angela Veloza, and Juan Carlos Sepúlveda-Arias. "Scale-Up of the Fermentation Process for the Production and Purification of Serratiopeptidase Using Silkworm Pupae as a Substrate." Methods and Protocols 7, no. 2 (2024): 19. http://dx.doi.org/10.3390/mps7020019.

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Serratiopeptidase, a bacterial metalloprotease known for its pain-relieving and anti-inflammatory properties, can be produced through fermentation with S. marcescens. This study aimed to identify key factors related to nutrient composition and physicochemical conditions for production in Erlenmeyer flasks and to scale up the mixture to a bioreactor to obtain the maximum proteolytic activity. A Plackett–Burman design was used to determine whether the presence of silkworm pupae (at 1.5%) was a significant parameter for serratiopeptidase production. Along with the variables pH, temperature, and t
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13

Passariello, C., A. Lucchese, F. Pera, and P. Gigola. "Clinical, Microbiological and Inflammatory Evidence of the Efficacy of Combination Therapy Including Serratiopeptidase in the Treatment of Periimplantitis." European Journal of Inflammation 10, no. 3 (2012): 463–72. http://dx.doi.org/10.1177/1721727x1201000322.

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The present study was aimed to evaluate the effect of introducing administration of the proteolytic enzyme serratiopeptidase in the combined mechanical-antibiotic treatment of periimplantitis (PI). Two randomized groups of 64 adults with a diagnosis of PI were studied over a 6-month period. All patients were treated with a combined mechanical and antibiotic protocol for 15 days. The experimental group (EG) was administered antibiotic and serratiopeptidase, while the control group was administered antibiotic alone. To evaluate the effects of the two treatment protocols, clinical and radiographi
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14

Atia, Yasir, Safaa Al-Thamiree, Shatha Salah, and Zaid Al-Attar. "Effect of proteolytic enzymes and insulin sensitiser in treatment of joint osteoarthritis in diabetic patients." Scripta Medica 55, no. 1 (2024): 79–84. http://dx.doi.org/10.5937/scriptamed55-45846.

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Background/Aim: Knee osteoarthritis is a frequently crippling chronic condition. Numerous pharmacological medications have been successfully utilised to treat knee osteoarthritis. This research aimed to compare the efficiency of metformin and serratiopeptidase in treating and preventing osteoarthritis development via distinct mechanisms. Methods: Between 1 January and 30 May 2019, a randomised-clinical-trial was done at Al-Kindy Hospital on 80 osteoarthritis patients, divided in two groups. Group I was given metformin 850 mg orally, whereas Group II was given serratiopeptidase 20 mg and metfor
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15

Masuda, Sawako, Yuichi Majima, Satoshi Saida, and Yasuo Sakakura. "Serratiopeptidase treatment of chronic sinusitis." Practica Oto-Rhino-Laryngologica 82, no. 5 (1989): 735–43. http://dx.doi.org/10.5631/jibirin.82.735.

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Melchor-Moncada, Jhon Jairo, Santiago Vasquez-Giraldo, Augusto Zuluaga-Vélez, Lina Marcela Orozco, Luz Angela Veloza, and Juan Carlos Sepúlveda-Arias. "Bioconjugation of Serratiopeptidase with Titanium Oxide Nanoparticles: Improving Stability and Antibacterial Properties." Journal of Functional Biomaterials 15, no. 10 (2024): 300. http://dx.doi.org/10.3390/jfb15100300.

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Antimicrobial resistance (AMR) poses a significant global health threat, necessitating the development of novel antibacterial strategies. Serratiopeptidase (SP), a metalloprotease produced by bacteria such as Serratia marcescens, has gained attention not only for its anti-inflammatory properties but also for its potential antibacterial activity. However, its protein nature makes it susceptible to pH changes and self-proteolysis, limiting its effectiveness. This study aimed to increase both the enzymatic stability and antibacterial activity of serratiopeptidase through immobilization on titaniu
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17

Dr., Gampa Vijay Kumar and M.Bala Vidya Sagar. "A STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LORNOXICAM, PARACETMOL AND SERRATIOPEPTIDASE IN COMBINED FORMULATION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 12 (2018): 16557–75. https://doi.org/10.5281/zenodo.2429537.

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<em>For routine analytical purpose it is desirable to establish methods capable of analyzing huge number of samples in a short time period with good robustness, accuracy and precision without any prior separation step. HPLC method generates large amount of quality data, which serve as highly powerful and convenient analytical tool. Lornoxicam &amp; Paracetamol was freely soluble in water and alcohol . Serratiopeptidase was freely soluble in alcohol and sparingly soluble in water. Methanol and potassium dihydrogen ortho phosphate( pH 3) was chosen as the mobile phase. The run time of the HPLC p
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18

Ateia, Yasir Abbas, Mohammed Sh Al-edanni, and Mohammed Ismail Al-qurtas. "IMPACT OF METFORMIN AND SERRATIOPEPTIDASE IN OBESE PATIENTS WITH KNEE OSTEOARTHRITIS." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 2 (2018): 37. http://dx.doi.org/10.22159/ijpps.2018v10i2.21834.

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Objective: Knee osteoarthritis is a common disabling chronic disease globally. Many pharmacological agents have been used efficiently in treatment of knee osteoarthritis. This study aims to evaluate metformin and serratiopeptidase together in treatment and stop of osteoarthritis progression by different mechanisms. Methods: Present study was a randomized clinical trial study conducted in Al-Kindi teaching hospital through the period from 1st January to 30th of May, 2017 on two groups of 80 osteoarthritis patients (group I; treated with metformin 850 mg oral tablets) and (group II; treated with
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Rani, Soniya, and Nardev Singh. "FORMULATION AND CHARACTERIZATION OF PERIODONTAL FILMS CONTAINING AZITHROMYCIN AND SERRATIOPEPTIDASE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (2018): 205. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.23032.

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Objective: The objective of the present work was to formulate and evaluate periodontal film, which could be capable of delivering therapeutic concentration of azithromycin and serratiopeptidase for a prolonged period of time and could be easily placed into the periodontal pocket. Methods: The films were prepared by solvent casting method using combinations of ethyl cellulose, hydroxypropyl methylcellulose K4M, hydroxypropyl methylcellulose 50 cps, eudragit L-100, and Chitosan in different ratios using dibutyl phthalate as plasticizer. The periodontal films were evaluated for weight variation,
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Rani, A. Prameela, and Annapurna Uppala. "Enteric dispersion or Serratiopeptidase with Eudragit L100 and Formulation of Controlled Release Tablets of Serratiopeptidase." International Journal of PharmTech Research 12, no. 02 (2019): 139–44. http://dx.doi.org/10.20902/ijptr.2019.120207.

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Muslikh, Faisal Akhmal, and Sukardiman. "Development and Challenges of Using Serratiopeptidase Enzymes as Anti-Inflammatory in the Present Era: Literature Review." Journal Pharmasci (Journal of Pharmacy and Science) 7, no. 2 (2022): 71–75. http://dx.doi.org/10.53342/pharmasci.v7i2.283.

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Enzymes are proteins that control and carry out metabolic activities in the body, either directly or indirectly. Enzymes have various advantages over traditional pharmaceuticals in terms of therapeutic efficacy and toxicity. They have great specificity and affinity for their target, minimizing toxicity. Use the terms "Serratiopeptidase enzyme" and "inflammation" to search publications in Google Scholar, Sciencedirect, SAGE journal, and Pubmed databases. According to ten articles, the serratiopeptidase enzyme has been shown to have an anti-inflammatory effect by reducing inflammatory cytokines
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Gupte, Vandana, and Umesh Luthra. "Analytical techniques for serratiopeptidase: A review." Journal of Pharmaceutical Analysis 7, no. 4 (2017): 203–7. http://dx.doi.org/10.1016/j.jpha.2017.03.005.

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Jadhav, Swati B., Neha Shah, Ankit Rathi, Vic Rathi, and Abhijit Rathi. "Serratiopeptidase: Insights into the therapeutic applications." Biotechnology Reports 28 (December 2020): e00544. http://dx.doi.org/10.1016/j.btre.2020.e00544.

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Parmar, Kinjal, Pinkal Patel, Pandurang Parate, and Janki Patel. "Development and Validation of Analytical Method for Simultaneous Estimation of Diclofenac Sodium and Serratiopeptidase in Bulk and Tablet Dosage Form." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 395–405. http://dx.doi.org/10.22270/jddt.v9i4.3076.

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Second order derivative spectroscopy method was developed and validated for the simultaneous estimation of Diclofenac sodium (DFS) and Serratiopeptidase (SPD) in bulk and tablet dosage form. Accurate and Précised UV Spectrophotometric method with good sensitivity has been developed for simultaneous estimation of DFS and SPD. The method employs Second order derivative based on the measurement of absorbance of DFS at ZCP 264.20 nm and SPD at ZCP 295.20 nm. The calibration curve was linear in a concentration range of 5-30 μg/ml for DFS and 25-150 μg/ml for SPD. The developed method was validated
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Chindhalore, Chaitali, Ganesh Natthuji Dakhale, Tamil Selvi Emperumal, and Sanjay Dhal. "Stevens–Johnson syndrome/toxic epidermal necrolysis overlap syndrome due to a fixed-dose combination of aceclofenac, serratiopeptidase, and paracetamol." National Journal of Pharmacology and Therapeutics 3, no. 1 (2025): 69–71. https://doi.org/10.4103/njpt.njpt_2_25.

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Abstract Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening, severe mucocutaneous adverse reactions, frequently drug-induced and characterized by extensive epidermal detachment, erosion of mucosa, and severe constitutional symptoms. However, to the best of our knowledge, no case report of aceclofenac-serratiopeptidase-paracetamol combination-induced SJS/TEN overlap syndrome has been published to date. We reported a case of SJS/TEN overlap syndrome in a 40-year-old female patient, who presented with a mucocutaneous ulcer over the face, trunk, upper an
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Menon, MalaD, and NM Nirale. "Topical formulations of serratiopeptidase: development and pharmacodynamic evaluation." Indian Journal of Pharmaceutical Sciences 72, no. 1 (2010): 65. http://dx.doi.org/10.4103/0250-474x.62246.

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Shinde, Ujwala A., and Shivkumar S. Kanojiya. "Serratiopeptidase Niosomal Gel with Potential in Topical Delivery." Journal of Pharmaceutics 2014 (March 20, 2014): 1–9. http://dx.doi.org/10.1155/2014/382959.

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The objective of present study was to develop nonionic surfactant vesicles of proteolytic enzyme serratiopeptidase (SRP) by adapting reverse phase evaporation (REV) technique and to evaluate the viability of SRP niosomal gel in treating the topical inflammation. The feasibility of SRP niosomes by REV method using Span 40 and cholesterol has been successfully demonstrated in this investigation. The entrapment efficiency was found to be influenced by the molar ratio of Span 40 : cholesterol and concentration of SRP in noisome. The developed niosomes were characterized for morphology, particle si
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Shimizu, H., M. Ueda, T. Takai, et al. "A case of serratiopeptidase-induced subepidermal bullous dermatosis." British Journal of Dermatology 141, no. 6 (1999): 1136–52. http://dx.doi.org/10.1046/j.1365-2133.1999.03225.x.

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Bhagat, Shivani, Monika Agarwal, and Vandana Roy. "Serratiopeptidase: A systematic review of the existing evidence." International Journal of Surgery 11, no. 3 (2013): 209–17. http://dx.doi.org/10.1016/j.ijsu.2013.01.010.

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Shende, Pravin K., Ravindra L. Bakal, R. S. Gaud, Kiran N. Batheja, and Madhugandha S. Kawadiwale. "Modulation of serratiopeptidase transdermal patch by lipid-based transfersomes." Journal of Adhesion Science and Technology 29, no. 23 (2015): 2622–33. http://dx.doi.org/10.1080/01694243.2015.1076592.

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Selan, Laura, Rosanna Papa, Angela Ermocida, et al. "Serratiopeptidase reduces the invasion of osteoblasts by Staphylococcus aureus." International Journal of Immunopathology and Pharmacology 30, no. 4 (2017): 423–28. http://dx.doi.org/10.1177/0394632017745762.

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Finding new strategies to counteract periprosthetic infection and implant failure is a main target in orthopedics. Staphylococcus aureus, the leading etiologic agent of orthopedic implant infections, is able to enter and kill osteoblasts, to stimulate pro-inflammatory chemokine secretion, to recruit osteoclasts, and to cause inflammatory osteolysis. Moreover, by entering eukaryotic cells, staphylococci hide from the host immune defenses and shelter from the extracellular antibiotics. Thus, infection persists, inflammation thrives, and a highly destructive osteomyelitis occurs around the implan
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Tiwari, Manju. "The role of serratiopeptidase in the resolution of inflammation." Asian Journal of Pharmaceutical Sciences 12, no. 3 (2017): 209–15. http://dx.doi.org/10.1016/j.ajps.2017.01.003.

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Kamenova, Katya, Anna Prancheva, Stiliyana Stoyanova, et al. "Functional Hydrogels for Delivery of the Proteolytic Enzyme Serratiopeptidase." Gels 10, no. 3 (2024): 156. http://dx.doi.org/10.3390/gels10030156.

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Hydrogels are superior wound dressings because they can provide protection and hydration of the wound, as well as the controlled release of therapeutic substances to aid tissue regeneration and the healing process. Hydrogels obtained from natural precursors are preferred because of their low cost, biocompatibility, and biodegradability. We describe the synthesis of novel functional hydrogels based on two natural products—citric acid (CA) and pentane-1,2,5-triol (PT, a product from lignocellulose processing) and poly(ethylene glycol) (PEG-600)—via an environment friendly approach. The hydrogels
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Reshma Harikrishnan, Arun Murugaiyan, Abhinav R P, and Balaji Ganesh S. "Commonly prescribed analgesics, post implant surgery - A retrospective study." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (2020): 1316–22. http://dx.doi.org/10.26452/ijrps.v11ispl3.3384.

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Postoperative pain management comes with any treatment done in dentistry. Pain is considered as a complex experience that's invoked by an external stimulus. Safe and reliable methods of managing acute dental pain can be done with the administration analgesics. Common analgesics include Diclofenac sodium, Ketrolac, Tramadol, Paracetamol, etc. Dental implants are biologically and restoratively driven. A retrospective study was done in an institutional setting. The data for the study were retrieved from the college's patient record management software. All patients who underwent implant surgery a
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., S. N. Kapse. "Simultaneous Estimation Serratiopeptidase and Diclofenac Sodium by UV-Spectrophotometric Method." Journal of Current Pharma Research 4, no. 2 (2014): 1406–10. http://dx.doi.org/10.33786/jcpr.2014.v04i02.011.

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., S. N. Kapse. "Simultaneous Estimation Serratiopeptidase and Diclofenac Sodium by UV-Spectrophotometric Method." Journal of Current Pharma Research 5, no. 1 (2014): 1406–10. http://dx.doi.org/10.33786/jcpr.2014.v05i01.010.

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M. Ashwini, S. Marakatham, and B. Raj Kamal. "Analytical Method Development and Validation of Aceclofenac and Serratiopeptidase by RPHPLC." International Journal of Enhanced Research In Science Technology & Engineering 12, no. 10 (2023): 46–53. http://dx.doi.org/10.55948/ijerste.2023.1008.

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Serratiopeptidase and Aceclofenac were measured and quantified using a quick, sensitive, and precise RPHPLC approach that was designed and validated using the Waters HPLC System with PDA detection. Chromatography was performed using a mobile step of filtered, mixed, degassed Methanol and Buffer (80:20)on a column of Inertsil-ODS C18 (250 x 4.6 mm, 5) at a flow rate of 1.0 ml/min. In addition to beingtested for quantification and detection limits, the system was also examined for linearity, precision, accuracy,and specificity.
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Santosh, Kitawat, Bharkatiya Meenakshi, and Dashora Nipun. "Formulation Development and Evaluation of Inlay Tablets of Anti-Inflammatory Drug." Pharmaceutical and Chemical Journal 6, no. 5 (2019): 18–27. https://doi.org/10.5281/zenodo.13942042.

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Tablets may be defined as solid pharmaceutical dosage forms containing drug substances with or without suitable diluents and prepared either by compression or molding methods. They have been in widespread use since the latter part of the 19<sup>th</sup> century and their popularity continues. In the present study inlay tablets of an anti-inflammatory drug was formulated and evaluated. The tablet is most widely used dosage form because of its ease of administration, compactness and ease of manufacturing. The aim of study is to formulate combination of an anti-inflammatory agent and proteolytic
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Rath, G., E. S. Johal, and Amit K. Goyal. "Development of Serratiopeptidase and Metronidazole Based Alginate Microspheres for Wound Healing." Artificial Cells, Blood Substitutes, and Biotechnology 39, no. 1 (2010): 44–50. http://dx.doi.org/10.3109/10731199.2010.494580.

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40

., Vaishali D. Rakibe, S. N. Kapse ., and Sadhana Mahajan . "Simultaneous Estimation of Serratiopeptidase and Diclofenac Sodium by UV-Spectrophotometric Method." Journal of Current Pharma Research 4, no. 4 (2014): 1297–301. http://dx.doi.org/10.33786/jcpr.2014.v04i04.006.

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41

Volovar, O. S., and O. O. Kryzhanivska. "SERRATIOPEPTIDASE IN THE COMPLEX TREATMENT AT PATIENTS WITH TEMPOROMANDIBULAR JOINT DISEASES." Scientific and practical journal "Stomatological Bulletin", no. 4 (2019): 50–56. http://dx.doi.org/10.35220/2078-8916-2019-34-4-50-56.

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42

Krishna, BPramod, BPraveen Reddy, DS Yashavanth Kumar, M. Ummar, Vijay Shekhar, and RahulVinay Chandra Tiwari. "Role of serratiopeptidase and dexamethasone in the control of postoperative swelling." Annals of Maxillofacial Surgery 10, no. 1 (2020): 108. http://dx.doi.org/10.4103/ams.ams_249_19.

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43

Metkar, Sanjay Kisan, Agnishwar Girigoswami, Ramachandran Murugesan, and Koyeli Girigoswami. "In vitro and in vivo insulin amyloid degradation mediated by Serratiopeptidase." Materials Science and Engineering: C 70 (January 2017): 728–35. http://dx.doi.org/10.1016/j.msec.2016.09.049.

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44

Rajvaidya, M., Y. Gupta, A. Jain, and S. K. Jain. "Development and characterization of multivesicular liposomes bearing serratiopeptidase for sustained delivery." Journal of Drug Delivery Science and Technology 17, no. 5 (2007): 315–20. http://dx.doi.org/10.1016/s1773-2247(07)50048-1.

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45

Jothieswari D, Srihari M V, Karthik R, Praveen Kumar V, and Sumit Giri. "Impact of Serratiopeptidase on Bleeding and Clotting Time at Therapeutic Dose." International Journal of Pharmaceutical Research and Life Sciences 11, no. 1 (2023): 1–4. http://dx.doi.org/10.26452/ijprls.v11i1.1460.

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Abstract:
Serratiopeptidase is a proteolytic enzyme that was being used for decades as an anti-inflammatory agent. It was initially synthesized from the larval form of the silk moth. It is ubiquitously prescribed in combination with NSAIDs to relieve pain and inflammation. In addition to desired pharmacological activity, it has some other effects. One among which is fibrinolytic activity. Fibrin is an activated form of fibrinogen formed as a result of injury to mitigate the loss of blood. Inactive plasminogen activates plasmin which is a proteolytic enzyme. As its chemical nature, it solubilizes the fib
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46

S, Manjula, and Krishna Kumar M. "Assessment of Pain Management Practices and Analgesic Prescription Patterns among Dental Practitioners in Indian Settings." South Asian Research Journal of Oral and Dental Sciences 7, no. 01 (2025): 1–7. https://doi.org/10.36346/sarjods.2024.v07i01.001.

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Objective: To evaluate the patterns of pain presentation, management strategies, and medication preferences among dental practitioners, with a specific focus on analgesic prescription practices in various dental conditions. Methods: A cross-sectional study was conducted among dental practitioners using the 24-item questionnaire to gather expert opinions on pain patterns, patient demographics, treatment timelines, and drug prescription practices. Descriptive statistics were used for analysis, with results visualized through pie and bar charts created in Microsoft Excel. Results: This study invo
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Т., Г. Романенко, та М. Суліменко О. "NEW PRINCIPLES OF TREATMENT OF VAGINAL DYSBIOSIS IN REPRODUCTIVE AGED WOMЕN". REPRODUCTIVE ENDOCRINOLOGY, № 49 (31 жовтня 2019): 62–66. https://doi.org/10.18370/2309-4117.2019.49.62-66.

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Purpose of the study. To investigate the efficiency and safety of combined treatment and prevention of bacterial vaginosis recurrence in women of reproductive age. Materials and methods. 78 women of reproductive age with diagnosed bacterial vaginosis were examined. 50 women are included in the main group, 28 women are included in the comparison group. Women in the main group were offered complex therapy: Samitol (secnidazole 500 mg) 1 g 2 times a day per os for 3 days, Gynex Forte (1 vaginal suppository contains metronidazole 750 mg, miconazole nitrate 200 mg) 1 time a day (overnight) for 7 da
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Roy, Vandana, and Vandana Tayal. "An Assessment of Availability, Cost and Rationality of Serratiopeptidase Preparations in India." MAMC Journal of Medical Sciences 3, no. 3 (2017): 152. http://dx.doi.org/10.4103/mamcjms.mamcjms_41_17.

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Artini, Marco, Gianluca Vrenna, Marika Trecca, et al. "Serratiopeptidase Affects the Physiology of Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients." International Journal of Molecular Sciences 23, no. 20 (2022): 12645. http://dx.doi.org/10.3390/ijms232012645.

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Pseudomonas aeruginosa is frequently involved in cystic fibrosis (CF) airway infections. Biofilm, motility, production of toxins and the invasion of host cells are different factors that increase P. aeruginosa’s virulence. The sessile phenotype offers protection to bacterial cells and resistance to antimicrobials and host immune attacks. Motility also contributes to bacterial colonization of surfaces and, consequently, to biofilm formation. Furthermore, the ability to adhere is the prelude for the internalization into lung cells, a common immune evasion mechanism used by most intracellular bac
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Pathak, Kamla, Vijay Sharma, KushalPal Singh, and Gulshan Chhabra. "Thermosensitive periodontal sol of ciprofloxacin hydrochloride and serratiopeptidase: Pharmaceutical and mechanical analysis." International Journal of Pharmaceutical Investigation 4, no. 1 (2014): 5. http://dx.doi.org/10.4103/2230-973x.127734.

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