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Relevant bibliographies by topics / Sertraline HCl

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Journal articles

Academic literature on the topic 'Sertraline HCl'

Author: Grafiati

Published: 4 June 2025

Last updated: 23 June 2025

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Journal articles on the topic "Sertraline HCl"

1

Rajendran, Vijaya. "Effect of niosomes in the transdermal delivery of antidepressant sertraline hydrochloride." Journal of Scientific and Innovative Research 5, no. 4 (2016): 138–43. http://dx.doi.org/10.31254/jsir.2016.5408.

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Objective: Sertraline hydrochloride is an antidepressant that undergoes hepatic first pass effect upon oral administration. Controlled delivery for prolonged period across skin is one of the solutions to improve its therapeutic efficacy. Here, niosomes has been used as a carrier for the transdermal transport of sertraline HCl. Material and Method: Sertraline HCl Niosomes were prepared by ether injection method using surfactants such as span 40(A), span 60(B) and span 80(C) along with cholesterol at a ratio of 1:1. Four different concentrations (200:200(Aa), 250:250(Ab), 300:300(Ac) & 350:350(Ad)) of surfactant and cholesterol were used for each surfactant. The niosomes were characterized in vitro for size and surface morphology by means of particle size analyzer and scanning electron microscope (SEM) respectively. Encapsulation efficiency was determined by high performance liquid chromatography. Sertraline HCl release and skin permeation studies were carried out using franz diffusion cell. At last, the optimized formulation was subjected to physical stability studies. Results: The SEM and size distribution analysis evidenced the formation of discrete, spherical niosomes. Higher encapsulation efficiency of 53.71%±3.2%, 51.18%±2.5% and 51.92%±2.7% were obtained for Ad, Bb and Bc respectively. A maximum sertraline HCl release of 70%±2.6% was obtained for Ad which showed a permeation of 2.71%±0.157% across mouse skin. A calculated 50.2%±0.9% of sertraline HCl was assumed to get accumulated in the skin layers and the niosomes were physically stable. Conclusion: Sertraline HCl niosome showed a slow and prolonged release of sertraline HCl through the mouse skin and thus holds promise for transdermal delivery.

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2

H. Samein, Laith, Ahmed A. Hussein, Alaa A. Abdulrasool, and Jabar A. Faraj. "Preparation and Characterization of Biodegradable Microspheres Containing Sertraline Hydrochloride." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 17, no. 1 (2017): 64–71. http://dx.doi.org/10.31351/vol17iss1pp64-71.

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Four batches of sertraline HCl microspheres were prepared using a poly (D-L-lactide-co-glycolide) (PLGA) polymer ( Mw. 9, 27, 30 and 83 KDa) as a delivery system. The microspheres were prepared by a dispersion/solvent extraction-evaporation method and characterized for drug loading by UV, particle size by laser diffractometry and surface morphology by scanning electron microscopy (SEM). The in vitro sertraline HCl release was studied. Spherical microspheres with a mean diameter of 21 to 26 Âµm loaded with 24.6 â€“ 38.2% were produced. The in vitro drug release was shown to be depend on polymer molecular weight and also on the drug loading. Differential scanning calorimetry (DSC) was employed to investigate the physical state of sertraline HCl inside the microspheres and stability and polymer interaction study were performed in solution. Key words: Sertraline HCl , Microspheres , PLGA polymer

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3

Amira, M. Ghoneim. "Spray dried self-nanoemulsifying drug delivery systems for sertraline HCl: Pharmacokinetic study in healthy volunteers." Int J Pharm Sci Dev Res 4, no. 1 (2018): 009–19. https://doi.org/10.17352/ijpsdr.000017.

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Purpose: The aim of this study is to improvelow oral bioavailability of sertraline HCl by formulation and characterization ofsolid self-nanoemulsifying drug delivery system [SNEDDS] using spray drying technique. Methods: Solubility of sertraline HCl in different vehicles was determined, and ternary phase diagrams were constructed.Various formulations were prepared and characterized by morphological characterization, differential scanning calorimetry and droplet size analysis. The formulations were evaluated for in vitro release profile in comparison to the marketed product [Lustral® tablets]. The in vivo study was performed on healthy human volunteers for pharmacokinetic analysis of the optimized formulations.

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4

El-Enany, N., M. I. Walash, F. Belal, and H. El-Mansi. "Spectrophotometric Determination of the Antidepressants Sertraline and Paroxetine HCl using 2,4-Dinitrofluorobenzene." International Journal of Biomedical Science 6, no. 3 (2010): 252–59. http://dx.doi.org/10.59566/ijbs.2010.6252.

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A simple and sensitive spectrophotometric method was developed for the determination of each of sertraline (SER) and paroxetine HCl (PXT ) in dosage forms. The method is based upon reaction of PXT and SER with 2,4-dinitrofluorobenzene (DNFB) to form colored products. The absorbance of the products were measured at 375and 390 nm for SER and PXT respectively. The absorbance concentration plots were rectilinear over the concentration rang of 1-10 and 2-20 μg/mL with lower detection limits (LOD) of 0.11 and 0.28 μg/mL and quantification limits (LOQ) of 0.32 and 0.85 μg/mL for SER and PXT, respectively. The developed method was successfully applied for the determination of SER and PXT in dosage forms. The common excipients and additives did not interfere in their determinations. There was no significant difference between the results obtained by the proposed and the reference methods regarding Student t-test and the variance ratio F-test respectively. A proposal of the reaction pathway was postulated.

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5

Vahora, Shifa, Usmangani K. Chhalotiya, Hetaben Kachhiya, Jinal Tandel, and Dimal Shah. "Simultaneous quantification of brexpiprazole and sertraline HCl in synthetic mixture by thin-layer chromatography method." JPC – Journal of Planar Chromatography – Modern TLC 34, no. 6 (2021): 549–57. http://dx.doi.org/10.1007/s00764-021-00142-4.

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6

Nagy, Christa F., Dinesh Kumar, Carlos A. Perdomo, Suman Wason, Edward I. Cullen, and Raymond D. Pratt. "Concurrent administration of donepezil HCl and sertraline HCl in healthy volunteers: assessment of pharmacokinetic changes and safety following single and multiple oral doses." British Journal of Clinical Pharmacology 58, s1 (2004): 25–33. http://dx.doi.org/10.1111/j.1365-2125.2004.01801.x.

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7

Putri, Dina Christin Ayuning. "Profil peresepan dan analisis risiko racikan antidepresan di sebuah apotek di Yogyakarta." Health Sciences and Pharmacy Journal 7, no. 2 (2023): 62–71. http://dx.doi.org/10.32504/hspj.v7i2.803.

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In Yogyakarta, the number of patients suffering from depression reached 5.5%. To enhance the therapeutic benefit, psychiatrists frequently prescribe a combination of antidepressants to their patients. To identify the risk for incompatibility, the prescription profile of antidepressant medicines that are compounded together must be examined. The purpose of this study is to examine the prescribing patterns of compounded medications designated as antidepressants in a Yogyakarta pharmacy. The prescription is the research subject in this descriptive exploratory study. Prescriptions that satisfied the inclusion criteria were gathered, and the frequency of prescriptions was calculated. Two medications with the greatest prescribing frequency were then examined for potential interactions and incompatibility. Folic acid is the most commonly prescribed medicine when combined with another. It was formerly used with sertraline HCl, maprotiline HCl, trifluoperazine HCl, and diazepam. The psychiatrist was used to mixing three to four active drugs administered in capsules. The drug combination has various interactions that must be properly monitored. These findings can be used by the doctor to choose the best medicine combination.

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8

Tajani, Amine Sadat, Atoosa Haghighizadeh, Vahid Soheili, Salim Mirshahi, and Omid Rajabi. "In Vitro Bioequivalence Study of 8 Generic and 3 Brands of Sertraline-HCl Tablets in Iran Market." Biomedical and Pharmacology Journal 10, no. 3 (2017): 1109–16. http://dx.doi.org/10.13005/bpj/1210.

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9

Babu, Mannem Durga, and Kesana Surendra Babu. "GC-HS Method for Organic Volatile Impurities Determination and Quantification in Sertraline HCl API and Its Pharmaceutical Dosage Forms." Asian Journal of Chemistry 30, no. 8 (2018): 1791–95. http://dx.doi.org/10.14233/ajchem.2018.21311.

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10

Ashishkumar, Panpatil* Vedant Salunke Snehal Jadhav Faisal Shaikh Pravin Jadhav Vinod Bairagi Kaushik Kamble. "A Review On The Analytical Method Development And Validation Of Sertralinetablet By UV Spectroscopy." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 995–10002. https://doi.org/10.5281/zenodo.11061087.

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Sertraline HCl (SRT) in tablet and bulk dose form was estimated using an easy-to-use, reasonably priced, and precise UV technique. We dissolved SRT using water as a diluent. To increase the solubility of the medication combination, it was sonicated for three minutes. The absorptions at 228.0 nm were chosen for additional examination of SRT in tablet and bulk dose forms. The suggested approach was verified in compliance with ICH regulations. At 228.0 nm, the technique demonstrated great sensitivity, with a linearity range of 5 to 30 μg/mL (r2=0.999). The lowest concentration was found to be 4.08, indicating the limit of quantization (LOQ) and the limit of detection (LOD) to be 1.22. According to the findings, utilising UV spectroscopy to estimate SRT in bulk and tablet dosage form proved to be an easy, precise, accurate, and quick process.

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